PLEC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as 'hemidesmosomal protein 1' or 'plectin 1, intermediate filament binding 500kDa'. These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)5.92212225
2cell adhesion mediated by integrin (GO:0033627)4.52723164
3activation of Rac GTPase activity (GO:0032863)4.34303560
4endodermal cell differentiation (GO:0035987)4.02567374
5semaphorin-plexin signaling pathway (GO:0071526)3.93376510
6apoptotic cell clearance (GO:0043277)3.92799785
7* hemidesmosome assembly (GO:0031581)3.86832787
8skin morphogenesis (GO:0043589)3.85869122
9regulation of integrin activation (GO:0033623)3.76758729
10dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.73194944
11positive regulation of p38MAPK cascade (GO:1900745)3.66515646
12* cell-substrate junction assembly (GO:0007044)3.64346999
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.64054636
14actin-myosin filament sliding (GO:0033275)3.50531225
15muscle filament sliding (GO:0030049)3.50531225
16regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.49991706
17collagen fibril organization (GO:0030199)3.48856949
18sarcomere organization (GO:0045214)3.46841153
19cytoskeletal anchoring at plasma membrane (GO:0007016)3.45942423
20wound healing, spreading of epidermal cells (GO:0035313)3.44383273
21negative regulation of fatty acid transport (GO:2000192)3.39448427
22protein heterotrimerization (GO:0070208)3.37197795
23COPI coating of Golgi vesicle (GO:0048205)3.33183083
24Golgi transport vesicle coating (GO:0048200)3.33183083
25regulation of p38MAPK cascade (GO:1900744)3.32047738
26endothelial cell chemotaxis (GO:0035767)3.29711438
27positive regulation of receptor recycling (GO:0001921)3.23867947
28barbed-end actin filament capping (GO:0051016)3.22716530
29epithelial cell-cell adhesion (GO:0090136)3.22008472
30actin filament-based movement (GO:0030048)3.21823046
31atrioventricular valve morphogenesis (GO:0003181)3.19948189
32actin-mediated cell contraction (GO:0070252)3.19730195
33protein localization to endosome (GO:0036010)3.19350266
34mesodermal cell differentiation (GO:0048333)3.18895492
35planar cell polarity pathway involved in neural tube closure (GO:0090179)3.18619351
36fibroblast migration (GO:0010761)3.18410194
37hypotonic response (GO:0006971)3.15147610
38positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.14028486
39regulation of tight junction assembly (GO:2000810)3.08729055
40regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.05382662
41neuron projection extension involved in neuron projection guidance (GO:1902284)3.04182305
42axon extension involved in axon guidance (GO:0048846)3.04182305
43regulation of early endosome to late endosome transport (GO:2000641)2.98838471
44cardiac myofibril assembly (GO:0055003)2.98527181
45vascular endothelial growth factor signaling pathway (GO:0038084)2.97753250
46mannose metabolic process (GO:0006013)2.96556673
47stress fiber assembly (GO:0043149)2.96229107
48chondrocyte proliferation (GO:0035988)2.95141055
49syncytium formation by plasma membrane fusion (GO:0000768)2.95133447
50regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.94367810
51positive regulation of Cdc42 GTPase activity (GO:0043089)2.94266696
52syncytium formation (GO:0006949)2.90043574
53branching involved in mammary gland duct morphogenesis (GO:0060444)2.84189985
54actomyosin structure organization (GO:0031032)2.83537549
55vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.83330735
56positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.82886807
57substrate-dependent cell migration (GO:0006929)2.81991548
58membrane raft organization (GO:0031579)2.80595548
59mRNA transcription (GO:0009299)2.80437315
60adherens junction assembly (GO:0034333)2.80245872
61regulation of skeletal muscle contraction (GO:0014819)2.79477626
62glomerular visceral epithelial cell development (GO:0072015)2.79418821
63myofibril assembly (GO:0030239)2.79128532
64response to fluid shear stress (GO:0034405)2.78674822
65positive regulation of endothelial cell apoptotic process (GO:2000353)2.77061954
66positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.76900942
67regulation of glucose import in response to insulin stimulus (GO:2001273)2.76798789
68mammary gland epithelial cell proliferation (GO:0033598)2.75288928
69desmosome organization (GO:0002934)2.74534178
70positive regulation of myotube differentiation (GO:0010831)2.73973943
71myoblast fusion (GO:0007520)2.72035324
72regulation of extracellular matrix disassembly (GO:0010715)2.69840836
73negative regulation of smooth muscle cell migration (GO:0014912)2.68162774
74striated muscle atrophy (GO:0014891)2.67564436
75basement membrane organization (GO:0071711)2.67545516
76regulation of water loss via skin (GO:0033561)2.66552984
77regulation of membrane protein ectodomain proteolysis (GO:0051043)2.66431000
78regulation of endothelial cell chemotaxis (GO:2001026)2.65970782
79negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.65944243
80collagen metabolic process (GO:0032963)2.65917795
81response to laminar fluid shear stress (GO:0034616)2.65324700
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.65146125
83actin filament bundle assembly (GO:0051017)2.64424736
84actin filament bundle organization (GO:0061572)2.64424736
85bundle of His cell to Purkinje myocyte communication (GO:0086069)2.64067397
86positive regulation of blood vessel endothelial cell migration (GO:0043536)2.63620072
87embryonic process involved in female pregnancy (GO:0060136)2.62350844
88negative regulation of chondrocyte differentiation (GO:0032331)2.62090010
89endothelial cell morphogenesis (GO:0001886)2.60695239
90insulin-like growth factor receptor signaling pathway (GO:0048009)2.60364260
91multicellular organismal macromolecule metabolic process (GO:0044259)2.58777634
92retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.58050895
93collagen catabolic process (GO:0030574)2.57885789
94positive regulation of osteoblast proliferation (GO:0033690)2.57453205
95substrate adhesion-dependent cell spreading (GO:0034446)2.54973369
96cellular response to interferon-alpha (GO:0035457)2.54007436
97cell volume homeostasis (GO:0006884)2.52566967
98skeletal muscle adaptation (GO:0043501)2.52450904
99cell-substrate adherens junction assembly (GO:0007045)2.52328400
100focal adhesion assembly (GO:0048041)2.52328400
101wound healing, spreading of cells (GO:0044319)2.52172334
102negative regulation of viral release from host cell (GO:1902187)2.51377607
103protein targeting to plasma membrane (GO:0072661)2.51187794
104multicellular organismal catabolic process (GO:0044243)2.49430482
105negative regulation of anoikis (GO:2000811)2.49232669
106extracellular matrix disassembly (GO:0022617)2.48760855
107membrane protein ectodomain proteolysis (GO:0006509)2.47961584
108integrin-mediated signaling pathway (GO:0007229)2.46154858
109regulation of interleukin-12 biosynthetic process (GO:0045075)2.44769237
110regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.44314935
111multicellular organismal metabolic process (GO:0044236)2.44295677
112* cell junction assembly (GO:0034329)2.44050909
113positive regulation of histone deacetylation (GO:0031065)2.43185278
114regulation of anoikis (GO:2000209)2.41444801
115positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.40549905
116cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.40081270
117glomerular epithelial cell development (GO:0072310)2.39666203
118actin filament depolymerization (GO:0030042)2.38601972
119cell-cell junction maintenance (GO:0045217)2.38574419
120establishment of skin barrier (GO:0061436)2.37612403
121negative regulation of cell size (GO:0045792)2.37290704
122sequestering of extracellular ligand from receptor (GO:0035581)2.37101066
123maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.36044764
124low-density lipoprotein particle clearance (GO:0034383)2.34442288
125epithelial cell differentiation involved in prostate gland development (GO:0060742)2.33913045
126protein retention in ER lumen (GO:0006621)2.33326339
127* cell junction organization (GO:0034330)2.33238173
128regulation of nucleobase-containing compound transport (GO:0032239)2.32949347
129actin cytoskeleton reorganization (GO:0031532)2.32207453
130adherens junction organization (GO:0034332)2.31829625
131blood vessel endothelial cell migration (GO:0043534)2.31556397
132positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.31425437
133negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.31192864
134activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.30688493
135cortical actin cytoskeleton organization (GO:0030866)2.30672411
136cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.29200101
137apoptotic process involved in morphogenesis (GO:0060561)2.28602967
138regulation of NFAT protein import into nucleus (GO:0051532)2.28415748
139protein hydroxylation (GO:0018126)2.28147509
140positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.27513514
141regulation of histone H3-K27 methylation (GO:0061085)2.26674269
142growth hormone receptor signaling pathway (GO:0060396)2.26543726
143renal filtration (GO:0097205)2.26515053
144positive regulation of natural killer cell differentiation (GO:0032825)2.26459364
145regulation of protein polyubiquitination (GO:1902914)2.26274749
146positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.25510032
147positive regulation of protein localization to plasma membrane (GO:1903078)2.25509798
148establishment of apical/basal cell polarity (GO:0035089)2.24482315
149platelet-derived growth factor receptor signaling pathway (GO:0048008)2.24321965
150response to muramyl dipeptide (GO:0032495)2.24164806
151Rho protein signal transduction (GO:0007266)2.23268855
152heterotypic cell-cell adhesion (GO:0034113)2.22229344
153protein localization to cell surface (GO:0034394)2.21089647
154cell migration involved in sprouting angiogenesis (GO:0002042)2.20320354
155positive thymic T cell selection (GO:0045059)2.17709959
156endocytic recycling (GO:0032456)2.16809585
157ruffle organization (GO:0031529)2.15241523
158positive regulation of gamma-delta T cell activation (GO:0046645)2.15027193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.00150809
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.49456871
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.37081368
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.89953452
5RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.29546746
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23852795
7* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.23762161
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.06495330
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.01636345
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.01349188
11* ELK3_25401928_ChIP-Seq_HUVEC_Human2.00140573
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92460956
13HIF1A_21447827_ChIP-Seq_MCF-7_Human1.92261605
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.90976778
15ESR1_21235772_ChIP-Seq_MCF-7_Human1.88860501
16GATA2_21666600_ChIP-Seq_HMVEC_Human1.87169950
17PPAR_26484153_Chip-Seq_NCI-H1993_Human1.83760029
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.83604792
19SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.83604792
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.83464967
21CLOCK_20551151_ChIP-Seq_293T_Human1.80173933
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80031001
23CJUN_26792858_Chip-Seq_BT549_Human1.78972061
24MYC_22102868_ChIP-Seq_BL_Human1.78927551
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77457704
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.72880260
27CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.71308644
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70330096
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68321141
30KDM2B_26808549_Chip-Seq_DND41_Human1.67746552
31SOX9_24532713_ChIP-Seq_HFSC_Mouse1.67067619
32* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65921412
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65197695
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.62269607
35* TCF7_22412390_ChIP-Seq_EML_Mouse1.61858466
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.59598046
37* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58461689
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56584821
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56004850
40P300_27058665_Chip-Seq_ZR-75-30cells_Human1.55267645
41RACK7_27058665_Chip-Seq_MCF-7_Human1.54796802
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53780497
43* TBX20_22328084_ChIP-Seq_HEART_Mouse1.52907006
44* TBX20_22080862_ChIP-Seq_HEART_Mouse1.52907006
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.52195331
46BRD4_25478319_ChIP-Seq_HGPS_Human1.49209594
47* ATF3_27146783_Chip-Seq_COLON_Human1.49069471
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44899416
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39786664
50* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39542414
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38825999
52* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38089341
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37283663
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36551775
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36374077
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35989650
57* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34063710
58* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33050914
59SPI1_23127762_ChIP-Seq_K562_Human1.32578221
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.32075113
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31265962
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31205271
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30834379
64TP53_22127205_ChIP-Seq_IMR90_Human1.30385441
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.30135178
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.29906057
67SMC4_20622854_ChIP-Seq_HELA_Human1.28750489
68KDM2B_26808549_Chip-Seq_K562_Human1.27077351
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26774581
70* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26703347
71* UBF1/2_26484160_Chip-Seq_HMECs_Human1.26287473
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24972393
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24739622
74* LXR_22292898_ChIP-Seq_THP-1_Human1.24415561
75* RUNX1_27514584_Chip-Seq_MCF-7_Human1.24393277
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24161123
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23326783
78VDR_21846776_ChIP-Seq_THP-1_Human1.23088427
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21707717
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20892694
81TP53_16413492_ChIP-PET_HCT116_Human1.19937899
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.19340470
83ZNF263_19887448_ChIP-Seq_K562_Human1.19148414
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17558219
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17241557
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16879308
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15314967
88KLF5_25053715_ChIP-Seq_YYC3_Human1.15284881
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15111039
90CREB1_26743006_Chip-Seq_LNCaP_Human1.14322383
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14302131
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14157494
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13921382
94* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.13261844
95NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13088323
96P68_20966046_ChIP-Seq_HELA_Human1.12928165
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12658490
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11499522
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11492969
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10053731
101ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09730411
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09655333
103KDM2B_26808549_Chip-Seq_JURKAT_Human1.09567108
104* MAF_26560356_Chip-Seq_TH1_Human1.09002637
105SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08794513
106IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08772506
107VDR_24763502_ChIP-Seq_THP-1_Human1.08417299
108SOX2_20726797_ChIP-Seq_SW620_Human1.07807401
109* TET1_21451524_ChIP-Seq_MESCs_Mouse1.07210119
110CDX2_20551321_ChIP-Seq_CACO-2_Human1.06750140
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05917626
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05158897
113RUNX_20019798_ChIP-Seq_JUKART_Human1.04959253
114TP63_22573176_ChIP-Seq_HFKS_Human1.04414944
115VDR_24787735_ChIP-Seq_THP-1_Human1.03926438
116RUNX1_22412390_ChIP-Seq_EML_Mouse1.03850914
117PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03345761
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03229473
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03047876
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02380473
121SA1_27219007_Chip-Seq_ERYTHROID_Human1.02377483
122TP53_23651856_ChIP-Seq_MEFs_Mouse1.02035971
123NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01790149
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01259982
125NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00065888
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00065888
127* TET1_21490601_ChIP-Seq_MESCs_Mouse0.99787436
128GATA2_19941826_ChIP-Seq_K562_Human0.97990222
129SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97726910
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95576895
131* NCOR1_26117541_ChIP-Seq_K562_Human0.92076392
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.91458749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.04528558
2MP0003705_abnormal_hypodermis_morpholog4.49743417
3MP0005275_abnormal_skin_tensile3.58230390
4MP0003279_aneurysm2.97387895
5MP0003566_abnormal_cell_adhesion2.92573013
6MP0010352_gastrointestinal_tract_polyps2.49337879
7MP0001958_emphysema2.34935550
8MP0005451_abnormal_body_composition2.32348108
9MP0000579_abnormal_nail_morphology2.31865678
10MP0005623_abnormal_meninges_morphology2.27257361
11MP0000569_abnormal_digit_pigmentation2.23047592
12MP0003300_gastrointestinal_ulcer2.22238921
13MP0005503_abnormal_tendon_morphology2.14740562
14MP0000733_abnormal_muscle_development2.12960816
15* MP0000749_muscle_degeneration2.12519693
16* MP0000751_myopathy2.08687801
17MP0009278_abnormal_bone_marrow2.02536769
18* MP0003091_abnormal_cell_migration2.01872786
19MP0005409_darkened_coat_color2.00821131
20MP0000750_abnormal_muscle_regeneration1.95618960
21MP0005076_abnormal_cell_differentiation1.92903158
22MP0003045_fibrosis1.92810770
23MP0004272_abnormal_basement_membrane1.89990177
24MP0002877_abnormal_melanocyte_morpholog1.88454013
25MP0004084_abnormal_cardiac_muscle1.85172810
26* MP0002060_abnormal_skin_morphology1.84830599
27* MP0005023_abnormal_wound_healing1.83167628
28* MP0004087_abnormal_muscle_fiber1.80289668
29MP0003191_abnormal_cellular_cholesterol1.79455856
30MP0001348_abnormal_lacrimal_gland1.74011456
31MP0003950_abnormal_plasma_membrane1.64157041
32MP0009840_abnormal_foam_cell1.60324998
33MP0004510_myositis1.58900827
34MP0000762_abnormal_tongue_morphology1.55354532
35MP0000767_abnormal_smooth_muscle1.53379663
36MP0008260_abnormal_autophagy1.50574778
37* MP0002796_impaired_skin_barrier1.50139079
38MP0000467_abnormal_esophagus_morphology1.48747365
39MP0000537_abnormal_urethra_morphology1.44917560
40MP0005257_abnormal_intraocular_pressure1.43461019
41* MP0000759_abnormal_skeletal_muscle1.39273954
42MP0002837_dystrophic_cardiac_calcinosis1.39146379
43MP0004947_skin_inflammation1.38986064
44* MP0010630_abnormal_cardiac_muscle1.38017138
45MP0003828_pulmonary_edema1.34870412
46MP0003303_peritoneal_inflammation1.31010576
47MP0010234_abnormal_vibrissa_follicle1.30658583
48* MP0005501_abnormal_skin_physiology1.30397712
49MP0005330_cardiomyopathy1.30367416
50MP0000013_abnormal_adipose_tissue1.30150156
51MP0000003_abnormal_adipose_tissue1.28836510
52MP0006054_spinal_hemorrhage1.25606823
53* MP0001216_abnormal_epidermal_layer1.25465389
54MP0000747_muscle_weakness1.23230431
55* MP0002106_abnormal_muscle_physiology1.22964533
56MP0002108_abnormal_muscle_morphology1.19372825
57MP0004233_abnormal_muscle_weight1.18021557
58MP0004036_abnormal_muscle_relaxation1.17629513
59MP0003436_decreased_susceptibility_to1.13227960
60MP0002166_altered_tumor_susceptibility1.12273554
61* MP0002269_muscular_atrophy1.12182811
62MP0002896_abnormal_bone_mineralization1.11304702
63MP0009384_cardiac_valve_regurgitation1.10896557
64MP0009780_abnormal_chondrocyte_physiolo1.10326893
65MP0004130_abnormal_muscle_cell1.09447807
66MP0005397_hematopoietic_system_phenotyp1.09003732
67MP0001545_abnormal_hematopoietic_system1.09003732
68MP0003453_abnormal_keratinocyte_physiol1.07745434
69MP0005508_abnormal_skeleton_morphology1.07146368
70* MP0005369_muscle_phenotype1.06698277
71MP0002168_other_aberrant_phenotype1.06139387
72* MP0001243_abnormal_dermal_layer1.05091101
73MP0002933_joint_inflammation1.04789696
74MP0001299_abnormal_eye_distance/1.04736517
75MP0010030_abnormal_orbit_morphology1.03951154
76MP0003172_abnormal_lysosome_physiology1.03932737
77MP0004808_abnormal_hematopoietic_stem1.02623126
78MP0001533_abnormal_skeleton_physiology1.02577552
79MP0002998_abnormal_bone_remodeling1.02094747
80MP0002089_abnormal_postnatal_growth/wei1.01923348
81MP0001849_ear_inflammation1.01601117
82MP0002972_abnormal_cardiac_muscle1.00598575
83MP0003448_altered_tumor_morphology1.00586602
84MP0010307_abnormal_tumor_latency0.99503637
85MP0005666_abnormal_adipose_tissue0.96961076
86MP0005385_cardiovascular_system_phenoty0.96156310
87MP0001544_abnormal_cardiovascular_syste0.96156310
88MP0003646_muscle_fatigue0.94806179
89MP0005620_abnormal_muscle_contractility0.93813838
90MP0005390_skeleton_phenotype0.93793574
91MP0000343_altered_response_to0.93395756
92* MP0005621_abnormal_cell_physiology0.92939076
93* MP0010771_integument_phenotype0.91836679
94* MP0002128_abnormal_blood_circulation0.91363979
95MP0005670_abnormal_white_adipose0.88553996
96MP0002254_reproductive_system_inflammat0.88416287
97MP0008775_abnormal_heart_ventricle0.88213006
98MP0002098_abnormal_vibrissa_morphology0.87568721
99MP0010678_abnormal_skin_adnexa0.86784170
100MP0002925_abnormal_cardiovascular_devel0.85940528
101MP0004264_abnormal_extraembryonic_tissu0.84884303
102MP0003329_amyloid_beta_deposits0.83579860
103MP0002006_tumorigenesis0.83410342
104MP0009053_abnormal_anal_canal0.82835209
105MP0005595_abnormal_vascular_smooth0.82819201
106MP0001915_intracranial_hemorrhage0.82626463
107MP0010368_abnormal_lymphatic_system0.82243551
108MP0006138_congestive_heart_failure0.81828256
109MP0004145_abnormal_muscle_electrophysio0.81233887
110* MP0009931_abnormal_skin_appearance0.81100119
111MP0001873_stomach_inflammation0.80126705
112MP0000858_altered_metastatic_potential0.79831043
113MP0003283_abnormal_digestive_organ0.77707236
114MP0001614_abnormal_blood_vessel0.77473980
115MP0002295_abnormal_pulmonary_circulatio0.77312772
116MP0001879_abnormal_lymphatic_vessel0.76871472
117MP0000678_abnormal_parathyroid_gland0.76635060
118MP0000377_abnormal_hair_follicle0.76598119
119MP0004185_abnormal_adipocyte_glucose0.76014105
120MP0003385_abnormal_body_wall0.74019631
121MP0000534_abnormal_ureter_morphology0.73900458
122* MP0000266_abnormal_heart_morphology0.71982509
123MP0001542_abnormal_bone_strength0.71874522
124MP0003115_abnormal_respiratory_system0.71424355
125MP0004484_altered_response_of0.71236777
126MP0003941_abnormal_skin_development0.69804672
127MP0005164_abnormal_response_to0.69463781
128MP0010155_abnormal_intestine_physiology0.69090994
129MP0002249_abnormal_larynx_morphology0.69041948
130MP0004858_abnormal_nervous_system0.68293622
131MP0003795_abnormal_bone_structure0.66258625
132MP0005083_abnormal_biliary_tract0.65698783
133MP0005464_abnormal_platelet_physiology0.65032071
134MP0000249_abnormal_blood_vessel0.64287673
135MP0005375_adipose_tissue_phenotype0.64180234
136MP0005058_abnormal_lysosome_morphology0.63098701

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.98998678
2Protrusio acetabuli (HP:0003179)4.94336047
3Type 1 muscle fiber predominance (HP:0003803)4.33674842
4Broad face (HP:0000283)4.06133382
5Distal lower limb amyotrophy (HP:0008944)4.01344652
6Atrophic scars (HP:0001075)4.00222849
7* Increased connective tissue (HP:0009025)3.86073130
8Ankle contracture (HP:0006466)3.81805021
9Cerebral aneurysm (HP:0004944)3.80959686
10Mildly elevated creatine phosphokinase (HP:0008180)3.63055983
11Hyporeflexia of lower limbs (HP:0002600)3.40818893
12Muscle fiber splitting (HP:0003555)3.36940334
13Spinal rigidity (HP:0003306)3.32972320
14Hyperacusis (HP:0010780)3.22651639
15Right ventricular cardiomyopathy (HP:0011663)3.19637815
16Lower limb amyotrophy (HP:0007210)3.15742100
17Aortic dissection (HP:0002647)3.07834414
18Shallow orbits (HP:0000586)3.06875620
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.04101709
20Aortic aneurysm (HP:0004942)3.00484762
21* Difficulty climbing stairs (HP:0003551)2.97648704
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.95792598
23Osteolytic defects of the hand bones (HP:0009699)2.95792598
24Cervical subluxation (HP:0003308)2.92269945
25Muscle fiber inclusion bodies (HP:0100299)2.90398214
26Dilatation of the ascending aorta (HP:0005111)2.89140773
27Peritonitis (HP:0002586)2.86172977
28Abnormality of skeletal muscle fiber size (HP:0012084)2.82671757
29Difficulty running (HP:0009046)2.82405497
30Distal lower limb muscle weakness (HP:0009053)2.81046331
31Increased variability in muscle fiber diameter (HP:0003557)2.77736616
32Short nail (HP:0001799)2.77308943
33Distal upper limb amyotrophy (HP:0007149)2.74989652
34Upper limb amyotrophy (HP:0009129)2.74989652
35Broad metatarsal (HP:0001783)2.73822895
36Abnormality of the distal phalanges of the toes (HP:0010182)2.69214961
37Obstructive sleep apnea (HP:0002870)2.64748001
38Wrist flexion contracture (HP:0001239)2.60495847
39* Fragile skin (HP:0001030)2.59787835
40Mitral valve prolapse (HP:0001634)2.59443132
41* Milia (HP:0001056)2.58643211
42Round ear (HP:0100830)2.57675484
43Abnormality of the calf musculature (HP:0001430)2.55165815
44Scapular winging (HP:0003691)2.54769189
45Increased density of long bones (HP:0006392)2.54733323
46Arterial tortuosity (HP:0005116)2.51645155
47Slender build (HP:0001533)2.50475600
48Natal tooth (HP:0000695)2.49614185
49Frequent falls (HP:0002359)2.49243806
50Vascular tortuosity (HP:0004948)2.43671126
51EMG: myopathic abnormalities (HP:0003458)2.38269883
52Abnormality of the distal phalanx of the thumb (HP:0009617)2.36480791
53Genu recurvatum (HP:0002816)2.35142647
54Absent frontal sinuses (HP:0002688)2.33129235
55Ulnar bowing (HP:0003031)2.32353373
56Bladder diverticulum (HP:0000015)2.32044154
57Spinal cord lesions (HP:0100561)2.31705887
58Syringomyelia (HP:0003396)2.31705887
59Wormian bones (HP:0002645)2.31629609
60Sudden death (HP:0001699)2.23487155
61Hypoplastic ischia (HP:0003175)2.22883815
62Nemaline bodies (HP:0003798)2.21310571
63Ventricular tachycardia (HP:0004756)2.20678857
64Myocardial infarction (HP:0001658)2.19713795
65Abnormality of oral frenula (HP:0000190)2.19399319
66Aneurysm (HP:0002617)2.19247943
67Exercise-induced muscle cramps (HP:0003710)2.18443499
68Vertebral compression fractures (HP:0002953)2.18411286
69Follicular hyperkeratosis (HP:0007502)2.17540287
70Selective tooth agenesis (HP:0001592)2.17397711
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.16884401
72Soft skin (HP:0000977)2.16230555
73Flat acetabular roof (HP:0003180)2.15338554
74Abnormality of the calcaneus (HP:0008364)2.12794573
75Neonatal short-limb short stature (HP:0008921)2.11221952
76Abnormality of the Achilles tendon (HP:0005109)2.10898439
77Radial bowing (HP:0002986)2.10737816
78Advanced eruption of teeth (HP:0006288)2.09518153
79Distal arthrogryposis (HP:0005684)2.08254718
80Disproportionate tall stature (HP:0001519)2.04467894
81Stridor (HP:0010307)2.03463664
82Ulnar deviation of the wrist (HP:0003049)2.03293786
83Cupped ribs (HP:0000887)2.03247954
84Ankyloglossia (HP:0010296)2.03111457
85Abnormality of the ischium (HP:0003174)2.02317086
86Blue sclerae (HP:0000592)2.01673901
87Spondylolisthesis (HP:0003302)2.01539123
88Insomnia (HP:0100785)1.98884589
89Elbow flexion contracture (HP:0002987)1.98627695
90Abnormal ossification of hand bones (HP:0005921)1.98299838
91Aortic regurgitation (HP:0001659)1.98147225
92Facial diplegia (HP:0001349)1.97726443
93* Nail dystrophy (HP:0008404)1.97158483
94Thin bony cortex (HP:0002753)1.96939884
95Dislocated radial head (HP:0003083)1.95713449
96Hip contracture (HP:0003273)1.95698744
97Fragile nails (HP:0001808)1.94617049
98Asymmetric septal hypertrophy (HP:0001670)1.89783409
99Lipoatrophy (HP:0100578)1.89503256
100Joint laxity (HP:0001388)1.88022873
101Limb-girdle muscle atrophy (HP:0003797)1.87560422
102Exercise-induced myalgia (HP:0003738)1.86408890
103Bowel diverticulosis (HP:0005222)1.85229361
104Tibial bowing (HP:0002982)1.83526050
105Long toe (HP:0010511)1.82432927
106Long palpebral fissure (HP:0000637)1.81407014
107Malignant hyperthermia (HP:0002047)1.81290864
108Hand muscle atrophy (HP:0009130)1.80584634
109Coxa vara (HP:0002812)1.80412291
110Abnormality of the radial head (HP:0003995)1.79016978
111Axonal loss (HP:0003447)1.78980256
112Calf muscle hypertrophy (HP:0008981)1.78557581
113Vertebral arch anomaly (HP:0008438)1.77744322
114Trismus (HP:0000211)1.76944279
115Mitral regurgitation (HP:0001653)1.76259300
116Increased mean platelet volume (HP:0011877)1.75780533
117Generalized amyotrophy (HP:0003700)1.75638738
118Overgrowth (HP:0001548)1.75193803
119Abnormality of carpal bone ossification (HP:0006257)1.74854390
120Myotonia (HP:0002486)1.72848870
121Bowing of the arm (HP:0006488)1.72167799
122Bowed forearm bones (HP:0003956)1.72167799
123Abnormality of the acetabulum (HP:0003170)1.71572546
124Hematochezia (HP:0002573)1.69549013
125Achilles tendon contracture (HP:0001771)1.69039016
126Pterygium (HP:0001059)1.68473409
127Supernumerary nipples (HP:0002558)1.68448505
128Reduced subcutaneous adipose tissue (HP:0003758)1.68365423
129Interstitial pulmonary disease (HP:0006530)1.68187038
130Camptodactyly of toe (HP:0001836)1.68136389
131Biconcave vertebral bodies (HP:0004586)1.68065593
132Abnormality of dentin (HP:0010299)1.67665344
133Cerebral inclusion bodies (HP:0100314)1.67575479
134Thin ribs (HP:0000883)1.66879480
135Myopathic facies (HP:0002058)1.65772272
136Atrial fibrillation (HP:0005110)1.63647929
137Aplasia cutis congenita (HP:0001057)1.61484816
138Nuclear cataract (HP:0100018)1.60847881
139Persistence of primary teeth (HP:0006335)1.59779748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.53029281
2TRIB33.78989931
3PKN22.69930589
4RIPK12.64136292
5DDR22.60955569
6IRAK32.60370547
7TRPM72.28282852
8PDGFRA2.06226521
9PRPF4B2.03064235
10SMG11.96986581
11DMPK1.89532568
12PTK61.81561258
13ERN11.73155999
14SIK11.71945823
15MAP2K31.68654028
16EEF2K1.67121196
17BMX1.59547930
18MAP3K31.56528037
19OBSCN1.51322169
20LATS11.49203606
21EPHA21.49161477
22CDK121.45222857
23MAP3K101.44874304
24EPHB11.43798591
25ICK1.35789670
26PTK21.33994432
27MAP3K131.25434591
28NTRK11.24951320
29STK101.24856488
30MAP3K61.20514537
31MTOR1.17181750
32PAK21.17001361
33LMTK21.16415391
34FGFR41.13728431
35PDGFRB1.13661601
36FRK1.12634279
37LRRK21.12518342
38JAK11.12355964
39FER1.09856458
40CAMK1D1.08408038
41JAK31.07944508
42TESK11.05869519
43PIK3CA1.05504364
44TBK11.04316277
45PTK2B1.04129635
46PIK3CG1.02310654
47MAP3K141.02022259
48PDK21.00477170
49PAK41.00445430
50STK30.99252974
51MST1R0.98779766
52PDK30.96315117
53PDK40.96315117
54MOS0.96255154
55PRKG20.92007452
56NEK90.91703312
57TAOK10.91649043
58NME20.91473997
59TGFBR20.90746329
60MAP3K70.86129434
61FGFR30.86052262
62ROCK10.85006868
63LATS20.81113171
64CAMK1G0.80385544
65ARAF0.79904804
66RPS6KA40.79896591
67KIT0.78892269
68TYK20.77964628
69MAPKAPK30.77784582
70EPHA30.73828946
71CDK60.72669686
72CHUK0.72413331
73PRKD30.72405264
74PRKCH0.69363037
75CSK0.67312299
76TAOK20.66139984
77MAP4K10.66010246
78MAP3K90.65575812
79MAPK110.65097616
80IRAK20.63182543
81MAP3K10.63129510
82EPHB20.59744699
83HCK0.58920270
84PIM20.58184569
85SCYL20.57278676
86ZAK0.56798931
87PRKD10.56483340
88PDPK10.56238742
89MAP3K110.56093595
90ERBB40.55621786
91ILK0.54405835
92MAP2K10.53100086
93MYLK0.53097385
94RET0.52155101
95RPS6KA20.51934617
96RPS6KL10.51157290
97RPS6KC10.51157290
98FGFR10.51046960
99MET0.49692061
100RPS6KA60.49620974
101KSR20.49519225
102PHKG20.49300334
103PHKG10.49300334
104MAP3K80.48858932
105PRKD20.48533955
106MAPK70.48254625
107MARK20.46696616
108STK380.45869309
109HIPK20.45561915
110SIK20.44569722
111SGK30.44556211
112IKBKB0.43968899
113MARK30.43832683
114ROCK20.43379946
115MELK0.43357996
116PAK30.42909523
117CAMKK10.42732074
118CDC42BPA0.41914867
119ZAP700.40340939
120PIM10.39614023
121INSR0.39129388
122ITK0.35958235
123MAPKAPK20.35821830
124MAP3K20.35432936
125FLT30.34171761
126ABL20.32322514
127CAMK2G0.30931317
128MAPK120.30810869
129CDK90.29547738
130GSK3A0.29323718
131TESK20.28359193
132MAPK100.27694117

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.70669127
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.42799078
3Focal adhesion_Homo sapiens_hsa045102.33892207
4Dilated cardiomyopathy_Homo sapiens_hsa054142.32412987
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.22487025
6Other glycan degradation_Homo sapiens_hsa005111.88175457
7Proteoglycans in cancer_Homo sapiens_hsa052051.87888180
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.86365797
9Amoebiasis_Homo sapiens_hsa051461.79017577
10Adherens junction_Homo sapiens_hsa045201.76456817
11Viral myocarditis_Homo sapiens_hsa054161.75227275
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.66851882
13Small cell lung cancer_Homo sapiens_hsa052221.62198632
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59912640
15Toxoplasmosis_Homo sapiens_hsa051451.52424829
16Chronic myeloid leukemia_Homo sapiens_hsa052201.47652539
17Malaria_Homo sapiens_hsa051441.47160824
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.41666321
19Salmonella infection_Homo sapiens_hsa051321.38889320
20Thyroid cancer_Homo sapiens_hsa052161.38673872
21Regulation of actin cytoskeleton_Homo sapiens_hsa048101.38259221
22Protein digestion and absorption_Homo sapiens_hsa049741.38093752
23Platelet activation_Homo sapiens_hsa046111.33063062
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.32304067
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29289328
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29189991
27Leishmaniasis_Homo sapiens_hsa051401.27264964
28Osteoclast differentiation_Homo sapiens_hsa043801.27022550
29Renal cell carcinoma_Homo sapiens_hsa052111.25405518
30TNF signaling pathway_Homo sapiens_hsa046681.22625816
31MicroRNAs in cancer_Homo sapiens_hsa052061.20915248
32Shigellosis_Homo sapiens_hsa051311.20718983
33ErbB signaling pathway_Homo sapiens_hsa040121.17844512
34Insulin resistance_Homo sapiens_hsa049311.13557873
35Bladder cancer_Homo sapiens_hsa052191.11311514
36Apoptosis_Homo sapiens_hsa042101.10941680
37Prion diseases_Homo sapiens_hsa050201.07762801
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.07104307
39Acute myeloid leukemia_Homo sapiens_hsa052211.06032741
40HIF-1 signaling pathway_Homo sapiens_hsa040661.04661289
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.04391951
42Caffeine metabolism_Homo sapiens_hsa002321.03594605
43Fructose and mannose metabolism_Homo sapiens_hsa000511.02433514
44VEGF signaling pathway_Homo sapiens_hsa043701.00224351
45mTOR signaling pathway_Homo sapiens_hsa041500.98702464
46Dorso-ventral axis formation_Homo sapiens_hsa043200.98259521
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96131257
48Inositol phosphate metabolism_Homo sapiens_hsa005620.94824238
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94626155
50Glioma_Homo sapiens_hsa052140.92248940
51Tight junction_Homo sapiens_hsa045300.91869480
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91453100
53Pancreatic cancer_Homo sapiens_hsa052120.89835174
54B cell receptor signaling pathway_Homo sapiens_hsa046620.89265609
55PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89099896
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.87965863
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87805367
58Renin-angiotensin system_Homo sapiens_hsa046140.87733614
59Type II diabetes mellitus_Homo sapiens_hsa049300.86836877
60Rap1 signaling pathway_Homo sapiens_hsa040150.86408459
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86297586
62Axon guidance_Homo sapiens_hsa043600.84923505
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84631075
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83230814
65Tuberculosis_Homo sapiens_hsa051520.82848513
66Hepatitis C_Homo sapiens_hsa051600.82261682
67Insulin signaling pathway_Homo sapiens_hsa049100.81973970
68Choline metabolism in cancer_Homo sapiens_hsa052310.81134015
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81074132
70Notch signaling pathway_Homo sapiens_hsa043300.79950245
71Endometrial cancer_Homo sapiens_hsa052130.79718617
72Pentose phosphate pathway_Homo sapiens_hsa000300.79153647
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78675721
74Prolactin signaling pathway_Homo sapiens_hsa049170.78511606
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.75927840
76Hepatitis B_Homo sapiens_hsa051610.75856223
77Legionellosis_Homo sapiens_hsa051340.74156474
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73902786
79TGF-beta signaling pathway_Homo sapiens_hsa043500.73864314
80Melanoma_Homo sapiens_hsa052180.73721625
81Pertussis_Homo sapiens_hsa051330.73654276
82Influenza A_Homo sapiens_hsa051640.73553992
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73274788
84Prostate cancer_Homo sapiens_hsa052150.73273488
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.72965434
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72825517
87Melanogenesis_Homo sapiens_hsa049160.71468186
88HTLV-I infection_Homo sapiens_hsa051660.69787251
89Measles_Homo sapiens_hsa051620.69469230
90Hippo signaling pathway_Homo sapiens_hsa043900.69436209
91Lysine degradation_Homo sapiens_hsa003100.69039936
92Mineral absorption_Homo sapiens_hsa049780.68840669
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68098831
94Estrogen signaling pathway_Homo sapiens_hsa049150.67596203
95Lysosome_Homo sapiens_hsa041420.67352948
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65971655
97Starch and sucrose metabolism_Homo sapiens_hsa005000.65881758
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65613196
99GnRH signaling pathway_Homo sapiens_hsa049120.65075358
100Colorectal cancer_Homo sapiens_hsa052100.64779845
101Phagosome_Homo sapiens_hsa041450.64466944
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64271035
103Pathways in cancer_Homo sapiens_hsa052000.63535444
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63486036
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63402754
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63168529
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62660258
108Endocytosis_Homo sapiens_hsa041440.62449464
109Gap junction_Homo sapiens_hsa045400.62322905
110Galactose metabolism_Homo sapiens_hsa000520.62114845
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.61838064
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61436467
113MAPK signaling pathway_Homo sapiens_hsa040100.60773555
114Viral carcinogenesis_Homo sapiens_hsa052030.58595810
115FoxO signaling pathway_Homo sapiens_hsa040680.58497857
116Hematopoietic cell lineage_Homo sapiens_hsa046400.57722949
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57610831
118Glucagon signaling pathway_Homo sapiens_hsa049220.57048965
119Non-small cell lung cancer_Homo sapiens_hsa052230.56628049
120AMPK signaling pathway_Homo sapiens_hsa041520.56208201
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.55783244
122Long-term potentiation_Homo sapiens_hsa047200.55541468
123Fatty acid biosynthesis_Homo sapiens_hsa000610.53716974
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.50680961

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