PLD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.37754768
2neuron cell-cell adhesion (GO:0007158)4.56625453
3presynaptic membrane assembly (GO:0097105)4.31554887
4cell proliferation in forebrain (GO:0021846)4.23418134
5somite development (GO:0061053)4.20032931
6negative regulation of synaptic transmission, GABAergic (GO:0032229)4.18059461
7presynaptic membrane organization (GO:0097090)4.16279444
8DNA deamination (GO:0045006)4.15116251
9vocalization behavior (GO:0071625)4.06285952
10water-soluble vitamin biosynthetic process (GO:0042364)4.05616013
11neuronal action potential propagation (GO:0019227)4.04821159
12establishment of protein localization to mitochondrial membrane (GO:0090151)3.98760689
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.88851288
14postsynaptic membrane organization (GO:0001941)3.88666730
15regulation of timing of cell differentiation (GO:0048505)3.86818803
16sulfation (GO:0051923)3.83853129
17protein polyglutamylation (GO:0018095)3.81276639
18serotonin metabolic process (GO:0042428)3.74260832
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.72787517
20endoderm formation (GO:0001706)3.71515127
21startle response (GO:0001964)3.64879994
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.58224870
23righting reflex (GO:0060013)3.56076842
24glutamate receptor signaling pathway (GO:0007215)3.48207538
25primary amino compound metabolic process (GO:1901160)3.46834119
26gamma-aminobutyric acid signaling pathway (GO:0007214)3.43627476
27regulation of glomerulus development (GO:0090192)3.36050172
28synaptic transmission, glutamatergic (GO:0035249)3.34504568
29neuron-neuron synaptic transmission (GO:0007270)3.33998252
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.33168712
31protein localization to synapse (GO:0035418)3.32759683
32ovulation cycle (GO:0042698)3.30588677
33positive regulation of cardiac muscle cell differentiation (GO:2000727)3.30182964
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.29240634
35negative regulation of homotypic cell-cell adhesion (GO:0034111)3.28645725
36gamma-aminobutyric acid transport (GO:0015812)3.28051604
37head development (GO:0060322)3.25816655
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25747577
39transmission of nerve impulse (GO:0019226)3.23931828
40cellular response to ATP (GO:0071318)3.23543326
41regulation of glutamate receptor signaling pathway (GO:1900449)3.22695002
42kidney morphogenesis (GO:0060993)3.21435404
43regulation of memory T cell differentiation (GO:0043380)3.21073583
44regulation of mesoderm development (GO:2000380)3.20480433
45cerebellar Purkinje cell differentiation (GO:0021702)3.19931174
46regulation of development, heterochronic (GO:0040034)3.17111652
47negative regulation of astrocyte differentiation (GO:0048712)3.16927278
48regulation of short-term neuronal synaptic plasticity (GO:0048172)3.10279885
49negative regulation of T-helper cell differentiation (GO:0045623)3.09659087
50negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.09659087
51membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.09231305
52positive regulation of fatty acid transport (GO:2000193)3.05740368
53adaptation of signaling pathway (GO:0023058)3.04534373
54neurotransmitter-gated ion channel clustering (GO:0072578)3.04209975
55positive regulation of synapse assembly (GO:0051965)3.02897609
56positive regulation of potassium ion transmembrane transport (GO:1901381)3.00931055
57positive regulation of glomerulus development (GO:0090193)2.98227317
58regulation of platelet aggregation (GO:0090330)2.97928899
59lateral sprouting from an epithelium (GO:0060601)2.97139804
60otic vesicle formation (GO:0030916)2.96645369
61negative regulation of transcription regulatory region DNA binding (GO:2000678)2.95993046
62cerebral cortex radially oriented cell migration (GO:0021799)2.95989847
63indolalkylamine metabolic process (GO:0006586)2.95310574
64epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95220778
65negative regulation of response to food (GO:0032096)2.93846312
66negative regulation of appetite (GO:0032099)2.93846312
67regulation of germinal center formation (GO:0002634)2.93754311
68membrane repolarization during action potential (GO:0086011)2.93504504
69spinal cord development (GO:0021510)2.92749336
70phosphorelay signal transduction system (GO:0000160)2.92534507
71regulation of T-helper 2 cell differentiation (GO:0045628)2.92132245
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91924264
73adult walking behavior (GO:0007628)2.91709103
74retinal ganglion cell axon guidance (GO:0031290)2.87887835
75positive regulation of synaptic transmission, GABAergic (GO:0032230)2.87775827
76energy coupled proton transport, down electrochemical gradient (GO:0015985)2.86858510
77ATP synthesis coupled proton transport (GO:0015986)2.86858510
78negative regulation of B cell mediated immunity (GO:0002713)2.85387095
79negative regulation of immunoglobulin mediated immune response (GO:0002890)2.85387095
80central nervous system myelination (GO:0022010)2.84995894
81axon ensheathment in central nervous system (GO:0032291)2.84995894
82positive regulation of oligodendrocyte differentiation (GO:0048714)2.84709875
83indole-containing compound metabolic process (GO:0042430)2.84510584
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.84136615
85regulation of action potential (GO:0098900)2.83124632
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.82353431
87protein complex biogenesis (GO:0070271)2.82330422
88positive regulation of cellular amide metabolic process (GO:0034250)2.81099360
89synaptic vesicle exocytosis (GO:0016079)2.81074657
90pharyngeal system development (GO:0060037)2.78977610
91detection of light stimulus involved in sensory perception (GO:0050962)2.78352350
92detection of light stimulus involved in visual perception (GO:0050908)2.78352350
93negative regulation of glycogen biosynthetic process (GO:0045719)2.77015647
94regulation of synapse assembly (GO:0051963)2.75733809
95neuronal action potential (GO:0019228)2.75535982
96auditory receptor cell stereocilium organization (GO:0060088)2.75459012
97mitochondrial respiratory chain complex I assembly (GO:0032981)2.75046968
98NADH dehydrogenase complex assembly (GO:0010257)2.75046968
99mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75046968
100synaptic transmission, cholinergic (GO:0007271)2.74800015
101cornea development in camera-type eye (GO:0061303)2.74124273
102G-protein coupled receptor internalization (GO:0002031)2.73700460
103regulation of synaptic transmission, GABAergic (GO:0032228)2.73684348
104positive regulation of icosanoid secretion (GO:0032305)2.72242606
105negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72090583
106purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.71869099
1073-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.71869099
108long-chain fatty acid biosynthetic process (GO:0042759)2.71631022
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.71467226
110reflex (GO:0060004)2.71308481
111behavioral response to pain (GO:0048266)2.71021402
112regulation of rhodopsin mediated signaling pathway (GO:0022400)2.70912468
113regulation of synaptic transmission, glutamatergic (GO:0051966)2.70869919
114cell morphogenesis involved in neuron differentiation (GO:0048667)2.70231344
115mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69975593
116synapse assembly (GO:0007416)2.69181222
117negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.68974910
118regulation of glycogen (starch) synthase activity (GO:2000465)2.68550553
119regulation of synapse maturation (GO:0090128)2.67601479
120serotonin receptor signaling pathway (GO:0007210)2.65533603
121tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.64783495
122RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.64783495
123positive regulation of action potential (GO:0045760)2.64758738
124negative regulation of neurotransmitter transport (GO:0051589)2.64516537
125locomotory exploration behavior (GO:0035641)2.64489760
126regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.63882400
127parturition (GO:0007567)2.63763904
128positive regulation of synapse maturation (GO:0090129)2.63245549
129regulation of non-canonical Wnt signaling pathway (GO:2000050)2.63035828
130membrane depolarization during action potential (GO:0086010)2.62549093
131response to pheromone (GO:0019236)2.62339142
132regulation of excitatory postsynaptic membrane potential (GO:0060079)2.61712528
133positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.61098464
134neuromuscular synaptic transmission (GO:0007274)2.60770349
135epithelial cilium movement (GO:0003351)2.59962534
136regulation of synaptic vesicle exocytosis (GO:2000300)2.59861421
137auditory behavior (GO:0031223)2.59399501
138regulation of membrane repolarization (GO:0060306)2.59176107
139opioid receptor signaling pathway (GO:0038003)2.59143766
140regulation of neurotransmitter uptake (GO:0051580)2.58841634
141neurotransmitter secretion (GO:0007269)2.58798664
142response to auditory stimulus (GO:0010996)2.58225967
143cranial nerve structural organization (GO:0021604)2.57112207
144glutamate secretion (GO:0014047)2.56831683
145synaptic vesicle endocytosis (GO:0048488)2.56672895
146regulation of neurotransmitter secretion (GO:0046928)2.56589956
147rhodopsin mediated signaling pathway (GO:0016056)2.54976580
148adult behavior (GO:0030534)2.54906810
149multicellular organismal signaling (GO:0035637)2.54844557
150positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.54642829
151piRNA metabolic process (GO:0034587)2.54384564
152positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.53324824
153spinal cord association neuron differentiation (GO:0021527)2.52395425
154membrane repolarization (GO:0086009)2.52255491
155membrane depolarization (GO:0051899)2.51028254
156action potential (GO:0001508)2.49586040
157positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.48519877
158neuron recognition (GO:0008038)2.48397330
159mechanosensory behavior (GO:0007638)2.48320421
160regulation of postsynaptic membrane potential (GO:0060078)2.48287986
161limb development (GO:0060173)2.48116574
162appendage development (GO:0048736)2.48116574
163cerebellar granule cell differentiation (GO:0021707)2.47181524
164regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.46702474
165dentate gyrus development (GO:0021542)2.46699891
166mitochondrial respiratory chain complex assembly (GO:0033108)2.46258996
167detection of calcium ion (GO:0005513)2.45163747
168neurotransmitter transport (GO:0006836)2.44816608
169positive regulation of mesonephros development (GO:0061213)2.44781118
170pituitary gland development (GO:0021983)2.44778919
171inner ear receptor stereocilium organization (GO:0060122)2.43564661
172lung secretory cell differentiation (GO:0061140)2.43395610
173negative regulation of systemic arterial blood pressure (GO:0003085)2.43011297
174adult locomotory behavior (GO:0008344)2.41380212
175L-amino acid import (GO:0043092)2.40715959
176long-term memory (GO:0007616)2.40333341
177negative regulation of dendrite morphogenesis (GO:0050774)2.39811705
178glycine transport (GO:0015816)2.39778650
179negative regulation of Rho protein signal transduction (GO:0035024)2.37472876
180regulation of respiratory system process (GO:0044065)2.36270775
181germinal center formation (GO:0002467)2.36226706
182keratinocyte development (GO:0003334)2.36220415
183behavioral response to ethanol (GO:0048149)2.35763147
184peripheral nervous system neuron development (GO:0048935)2.34325101
185extracellular regulation of signal transduction (GO:1900115)2.34244355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.24483971
2GBX2_23144817_ChIP-Seq_PC3_Human4.17174753
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.69686577
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.28656627
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64916557
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.64439988
7TAF15_26573619_Chip-Seq_HEK293_Human2.54992232
8* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53091323
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52106141
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.44683654
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33830455
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.30107685
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29770925
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26940157
15ZNF274_21170338_ChIP-Seq_K562_Hela2.23680252
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22498933
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22498933
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20815519
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18379095
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15353783
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08033730
22IGF1R_20145208_ChIP-Seq_DFB_Human2.02071779
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01287209
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98357488
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97057404
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.94253758
27* EZH2_27294783_Chip-Seq_ESCs_Mouse1.89166481
28* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88559682
29* P300_19829295_ChIP-Seq_ESCs_Human1.87222415
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.86568763
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84415203
32* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83599389
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.81607794
34* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81039624
35SMAD4_21799915_ChIP-Seq_A2780_Human1.79744488
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78622771
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76259132
38* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75271661
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72464083
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.71613993
41REST_21632747_ChIP-Seq_MESCs_Mouse1.71409395
42AR_21572438_ChIP-Seq_LNCaP_Human1.70426129
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.68168008
44* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66832590
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64752177
46VDR_22108803_ChIP-Seq_LS180_Human1.64732838
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64635417
48RNF2_27304074_Chip-Seq_NSC_Mouse1.63575657
49EWS_26573619_Chip-Seq_HEK293_Human1.63223570
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59304125
51* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59223439
52DROSHA_22980978_ChIP-Seq_HELA_Human1.59043882
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58995448
54* NANOG_18555785_Chip-Seq_ESCs_Mouse1.56784448
55* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51850466
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51549832
57IRF1_19129219_ChIP-ChIP_H3396_Human1.50791402
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.50719705
59* NFE2_27457419_Chip-Seq_LIVER_Mouse1.49581996
60* E2F1_18555785_Chip-Seq_ESCs_Mouse1.48114158
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45861923
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45249911
63* P53_22387025_ChIP-Seq_ESCs_Mouse1.44360867
64* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42308074
65* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41909614
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40916016
67* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.40251049
68ER_23166858_ChIP-Seq_MCF-7_Human1.39856987
69* CMYC_18555785_Chip-Seq_ESCs_Mouse1.39506018
70* EZH2_27294783_Chip-Seq_NPCs_Mouse1.39276313
71* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38958866
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37177026
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36923785
74* STAT3_18555785_Chip-Seq_ESCs_Mouse1.35308147
75* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34725283
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34232656
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33140297
78* STAT3_23295773_ChIP-Seq_U87_Human1.32541137
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31107655
80* P300_18555785_Chip-Seq_ESCs_Mouse1.30682430
81FUS_26573619_Chip-Seq_HEK293_Human1.30403273
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29132374
83* NMYC_18555785_Chip-Seq_ESCs_Mouse1.28740085
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27684257
85* AR_25329375_ChIP-Seq_VCAP_Human1.27334358
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24209080
87* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23302259
88* SOX2_18555785_Chip-Seq_ESCs_Mouse1.20988767
89TCF4_23295773_ChIP-Seq_U87_Human1.20673874
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.19506071
91* TP53_18474530_ChIP-ChIP_U2OS_Human1.18996420
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18213084
93CBP_20019798_ChIP-Seq_JUKART_Human1.18213084
94* RUNX2_22187159_ChIP-Seq_PCA_Human1.17881342
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17314040
96AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17138597
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16952801
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.16670364
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16002980
100* OCT4_18555785_Chip-Seq_ESCs_Mouse1.14703246
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14109490
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14109490
103FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13115942
104FOXA1_25329375_ChIP-Seq_VCAP_Human1.13115942
105NCOR_22424771_ChIP-Seq_293T_Human1.12854313
106* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12544146
107* REST_18959480_ChIP-ChIP_MESCs_Mouse1.11837731
108* PU1_27457419_Chip-Seq_LIVER_Mouse1.11458415
109BCAT_22108803_ChIP-Seq_LS180_Human1.10843645
110KDM2B_26808549_Chip-Seq_REH_Human1.10450142
111* RING1B_27294783_Chip-Seq_ESCs_Mouse1.10421424
112POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10235725
113* KLF4_18555785_Chip-Seq_ESCs_Mouse1.08544279
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08458335
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.07555890
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07489122
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.06876662
118* ZFX_18555785_Chip-Seq_ESCs_Mouse1.06763414
119SOX2_19829295_ChIP-Seq_ESCs_Human1.06565025
120NANOG_19829295_ChIP-Seq_ESCs_Human1.06565025
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06072097
122* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05792482
123* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05594927
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05310986
125AHR_22903824_ChIP-Seq_MCF-7_Human1.05165592
126NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04698650
127* CTCF_18555785_Chip-Seq_ESCs_Mouse1.04555994
128MYC_18940864_ChIP-ChIP_HL60_Human1.03588152
129ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01736883
130TP53_22573176_ChIP-Seq_HFKS_Human0.99185602
131GATA1_26923725_Chip-Seq_HPCs_Mouse0.98173871
132NOTCH1_21737748_ChIP-Seq_TLL_Human0.97737414
133SMAD4_21741376_ChIP-Seq_EPCs_Human0.94881430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.69336346
2MP0001188_hyperpigmentation3.50095816
3MP0003646_muscle_fatigue3.40478580
4MP0002837_dystrophic_cardiac_calcinosis3.27272706
5MP0002735_abnormal_chemical_nociception3.14091848
6MP0001968_abnormal_touch/_nociception3.12800263
7MP0003011_delayed_dark_adaptation3.06989126
8MP0009046_muscle_twitch2.99244237
9MP0004859_abnormal_synaptic_plasticity2.98771061
10MP0002736_abnormal_nociception_after2.81048758
11MP0009745_abnormal_behavioral_response2.73013846
12MP0005645_abnormal_hypothalamus_physiol2.64957212
13MP0003635_abnormal_synaptic_transmissio2.58964456
14MP0005646_abnormal_pituitary_gland2.47171146
15MP0001486_abnormal_startle_reflex2.46515129
16MP0002734_abnormal_mechanical_nocicepti2.42116584
17MP0001986_abnormal_taste_sensitivity2.38121427
18MP0005423_abnormal_somatic_nervous2.33175998
19MP0002064_seizures2.31042652
20MP0006276_abnormal_autonomic_nervous2.30070854
21MP0002272_abnormal_nervous_system2.24181196
22MP0004270_analgesia2.24028751
23MP0002160_abnormal_reproductive_system2.22365123
24MP0002572_abnormal_emotion/affect_behav2.16721106
25MP0005171_absent_coat_pigmentation2.15951503
26MP0002067_abnormal_sensory_capabilities2.15117658
27MP0001984_abnormal_olfaction2.12537831
28MP0000566_synostosis2.08420557
29MP0006292_abnormal_olfactory_placode2.07444221
30MP0004142_abnormal_muscle_tone2.05103993
31MP0002063_abnormal_learning/memory/cond1.95944368
32MP0001501_abnormal_sleep_pattern1.95675847
33MP0002184_abnormal_innervation1.87528635
34MP0005389_reproductive_system_phenotype1.87196953
35MP0001440_abnormal_grooming_behavior1.86757105
36MP0004742_abnormal_vestibular_system1.83436724
37MP0001970_abnormal_pain_threshold1.82894926
38MP0005377_hearing/vestibular/ear_phenot1.82484933
39MP0003878_abnormal_ear_physiology1.82484933
40MP0005379_endocrine/exocrine_gland_phen1.79813526
41MP0002102_abnormal_ear_morphology1.79042683
42MP0002733_abnormal_thermal_nociception1.77405169
43MP0002557_abnormal_social/conspecific_i1.72747731
44MP0008877_abnormal_DNA_methylation1.70892025
45MP0003136_yellow_coat_color1.68889246
46MP0002653_abnormal_ependyma_morphology1.64233328
47MP0009379_abnormal_foot_pigmentation1.53151261
48MP0005409_darkened_coat_color1.51735754
49MP0008872_abnormal_physiological_respon1.50272621
50MP0003787_abnormal_imprinting1.48456044
51MP0001529_abnormal_vocalization1.47550375
52MP0003567_abnormal_fetal_cardiomyocyte1.45966197
53MP0000778_abnormal_nervous_system1.43458825
54MP0000015_abnormal_ear_pigmentation1.41771954
55MP0001905_abnormal_dopamine_level1.38416833
56MP0001502_abnormal_circadian_rhythm1.36978231
57MP0002822_catalepsy1.36795110
58MP0008569_lethality_at_weaning1.34851961
59MP0004130_abnormal_muscle_cell1.32200873
60MP0002876_abnormal_thyroid_physiology1.32022553
61MP0000631_abnormal_neuroendocrine_gland1.31794429
62MP0003119_abnormal_digestive_system1.30833470
63MP0004133_heterotaxia1.30565338
64MP0001919_abnormal_reproductive_system1.29836852
65MP0005551_abnormal_eye_electrophysiolog1.26638659
66MP0004924_abnormal_behavior1.25985068
67MP0005386_behavior/neurological_phenoty1.25985068
68MP0001963_abnormal_hearing_physiology1.24753548
69MP0002277_abnormal_respiratory_mucosa1.24457472
70MP0008260_abnormal_autophagy1.23417853
71MP0003879_abnormal_hair_cell1.20904618
72MP0002638_abnormal_pupillary_reflex1.19015218
73MP0009053_abnormal_anal_canal1.19011825
74MP0000569_abnormal_digit_pigmentation1.18046363
75MP0005195_abnormal_posterior_eye1.17540316
76MP0000026_abnormal_inner_ear1.17528075
77MP0000955_abnormal_spinal_cord1.14479036
78MP0002882_abnormal_neuron_morphology1.10835272
79MP0010386_abnormal_urinary_bladder1.10481696
80MP0004145_abnormal_muscle_electrophysio1.10216204
81MP0000537_abnormal_urethra_morphology1.09393237
82MP0002138_abnormal_hepatobiliary_system1.09176706
83MP0003890_abnormal_embryonic-extraembry1.08298535
84MP0003937_abnormal_limbs/digits/tail_de1.08211369
85MP0000383_abnormal_hair_follicle1.07510378
86MP0006072_abnormal_retinal_apoptosis1.06411506
87MP0000372_irregular_coat_pigmentation1.05770982
88MP0008775_abnormal_heart_ventricle1.04568508
89MP0009250_abnormal_appendicular_skeleto1.04339975
90MP0002752_abnormal_somatic_nervous1.03431071
91MP0003195_calcinosis0.99628998
92MP0004147_increased_porphyrin_level0.99254921
93MP0002066_abnormal_motor_capabilities/c0.97826895
94MP0003941_abnormal_skin_development0.96756957
95MP0002751_abnormal_autonomic_nervous0.96695913
96MP0005394_taste/olfaction_phenotype0.96657774
97MP0005499_abnormal_olfactory_system0.96657774
98MP0003283_abnormal_digestive_organ0.95358908
99MP0005671_abnormal_response_to0.93715986
100MP0001293_anophthalmia0.91523011
101MP0004381_abnormal_hair_follicle0.90663855
102MP0002938_white_spotting0.90628788
103MP0001348_abnormal_lacrimal_gland0.89990629
104MP0005253_abnormal_eye_physiology0.89347992
105MP0003122_maternal_imprinting0.89277172
106MP0001485_abnormal_pinna_reflex0.87806913
107MP0009697_abnormal_copulation0.85593004
108MP0005084_abnormal_gallbladder_morpholo0.84692016
109MP0003938_abnormal_ear_development0.84061897
110MP0005360_urolithiasis0.82072171
111MP0002163_abnormal_gland_morphology0.80902272
112MP0003121_genomic_imprinting0.80659329
113MP0002234_abnormal_pharynx_morphology0.80157031
114MP0008789_abnormal_olfactory_epithelium0.79825950
115MP0003942_abnormal_urinary_system0.79820678
116MP0005174_abnormal_tail_pigmentation0.78596752
117MP0002229_neurodegeneration0.77734997
118MP0000920_abnormal_myelination0.75708283
119MP0005187_abnormal_penis_morphology0.74596404
120MP0004811_abnormal_neuron_physiology0.74266182
121MP0000049_abnormal_middle_ear0.72639962
122MP0003690_abnormal_glial_cell0.70404400
123MP0002249_abnormal_larynx_morphology0.70274359
124MP0008995_early_reproductive_senescence0.70029551
125MP0000681_abnormal_thyroid_gland0.68277639
126MP0004484_altered_response_of0.65309027
127MP0001346_abnormal_lacrimal_gland0.65177141
128MP0001664_abnormal_digestion0.64900591
129MP0005451_abnormal_body_composition0.64856260
130MP0003633_abnormal_nervous_system0.64624718
131MP0002152_abnormal_brain_morphology0.64303870
132MP0004858_abnormal_nervous_system0.62599940
133MP0004885_abnormal_endolymph0.59001333
134MP0003631_nervous_system_phenotype0.58945358
135MP0001177_atelectasis0.58586755
136MP0002069_abnormal_eating/drinking_beha0.57783347
137MP0002177_abnormal_outer_ear0.55801231

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.97243780
2Febrile seizures (HP:0002373)5.86052447
3Epileptic encephalopathy (HP:0200134)3.75897351
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.67271554
5Upper limb muscle weakness (HP:0003484)3.60177322
6Focal seizures (HP:0007359)3.54499060
7Abnormality of the proximal phalanges of the hand (HP:0009834)3.49881993
8Atonic seizures (HP:0010819)3.49843859
9Pancreatic cysts (HP:0001737)3.43724243
10Pendular nystagmus (HP:0012043)3.40329553
11Abnormality of the middle phalanges of the toes (HP:0010183)3.34261983
12Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.26411755
13Abnormal rod and cone electroretinograms (HP:0008323)3.20350996
14Progressive cerebellar ataxia (HP:0002073)3.19325196
15Molar tooth sign on MRI (HP:0002419)3.19286310
16Abnormality of midbrain morphology (HP:0002418)3.19286310
17Symphalangism affecting the phalanges of the hand (HP:0009773)3.13392053
18Abnormality of the parathyroid morphology (HP:0011766)3.09506691
19Abnormality of the phalanges of the 5th finger (HP:0004213)3.06531093
20Chromsome breakage (HP:0040012)3.03081173
21Abolished electroretinogram (ERG) (HP:0000550)2.96383304
22Short hallux (HP:0010109)2.85957682
23Gaze-evoked nystagmus (HP:0000640)2.85120812
24Septo-optic dysplasia (HP:0100842)2.83466278
25Hypoplasia of the uterus (HP:0000013)2.79704857
26Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.76543585
27Prostate neoplasm (HP:0100787)2.75691212
28Hyperventilation (HP:0002883)2.74759903
29Aplasia/Hypoplasia of the hallux (HP:0008362)2.74547301
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.73493284
31Hypothermia (HP:0002045)2.69779096
32Medial flaring of the eyebrow (HP:0010747)2.69328654
33Abnormality of the phalanges of the 2nd finger (HP:0009541)2.68091122
34Abnormal hair whorl (HP:0010721)2.67923723
35Broad-based gait (HP:0002136)2.63098286
36Abnormality of the renal medulla (HP:0100957)2.62580619
37Asplenia (HP:0001746)2.61806398
38Generalized tonic-clonic seizures (HP:0002069)2.60475064
39Aplasia/Hypoplasia of the spleen (HP:0010451)2.59936415
40Absent/shortened dynein arms (HP:0200106)2.58786793
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.58786793
42Dialeptic seizures (HP:0011146)2.58112431
43Gait imbalance (HP:0002141)2.57579941
44Myokymia (HP:0002411)2.57059712
45Congenital stationary night blindness (HP:0007642)2.53653281
46Nephrogenic diabetes insipidus (HP:0009806)2.51969200
47Genetic anticipation (HP:0003743)2.50640179
48Absence seizures (HP:0002121)2.50528662
49Synostosis involving the elbow (HP:0003938)2.48199837
50Humeroradial synostosis (HP:0003041)2.48199837
51Congenital primary aphakia (HP:0007707)2.47784984
52Abnormality of the renal cortex (HP:0011035)2.47521154
53Aplasia/hypoplasia of the uterus (HP:0008684)2.44193946
54Fetal akinesia sequence (HP:0001989)2.41782654
55Genital tract atresia (HP:0001827)2.41314658
56Decreased central vision (HP:0007663)2.41226709
57Methylmalonic acidemia (HP:0002912)2.41202641
58Congenital, generalized hypertrichosis (HP:0004540)2.40913229
59Chorioretinal atrophy (HP:0000533)2.40506592
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.38946758
61Parakeratosis (HP:0001036)2.36361725
62Optic nerve hypoplasia (HP:0000609)2.35358910
63Ulnar claw (HP:0001178)2.33745301
64Vaginal atresia (HP:0000148)2.33184377
65Type II lissencephaly (HP:0007260)2.32137422
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.31715811
67Short tibia (HP:0005736)2.28609230
68Hyperglycinemia (HP:0002154)2.28347488
69Esotropia (HP:0000565)2.28265187
70Aplasia cutis congenita (HP:0001057)2.27480016
71Abnormal ciliary motility (HP:0012262)2.26624954
72Agitation (HP:0000713)2.25022194
73Synostosis of carpal bones (HP:0005048)2.24223223
74Abnormality of alanine metabolism (HP:0010916)2.18810399
75Hyperalaninemia (HP:0003348)2.18810399
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18810399
77Bony spicule pigmentary retinopathy (HP:0007737)2.18661641
78Sclerocornea (HP:0000647)2.18432122
79Limb dystonia (HP:0002451)2.17648035
80Cystic liver disease (HP:0006706)2.17042319
81Fibular aplasia (HP:0002990)2.13992760
82True hermaphroditism (HP:0010459)2.11209368
83Short 1st metacarpal (HP:0010034)2.10971737
84Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.10971737
85Renal cortical cysts (HP:0000803)2.09335251
86Stomach cancer (HP:0012126)2.09282740
87White forelock (HP:0002211)2.06608855
88Methylmalonic aciduria (HP:0012120)2.06329986
89Patchy hypopigmentation of hair (HP:0011365)2.05785052
90Short femoral neck (HP:0100864)2.04877425
91Action tremor (HP:0002345)2.04786116
92Specific learning disability (HP:0001328)2.00926647
93Osteomalacia (HP:0002749)2.00427122
94Nonprogressive disorder (HP:0003680)2.00383126
95Chronic hepatic failure (HP:0100626)2.00072387
96Abnormality of the lacrimal duct (HP:0011481)1.98739488
97Aplasia/Hypoplasia of the lens (HP:0008063)1.97326902
98IgG deficiency (HP:0004315)1.95493444
99Pancreatic fibrosis (HP:0100732)1.94328920
100Attenuation of retinal blood vessels (HP:0007843)1.94186775
101Tubular atrophy (HP:0000092)1.93250502
102Submucous cleft hard palate (HP:0000176)1.93198275
103Bradycardia (HP:0001662)1.92703155
104Absent septum pellucidum (HP:0001331)1.92532782
105Increased corneal curvature (HP:0100692)1.92525019
106Keratoconus (HP:0000563)1.92525019
107Progressive inability to walk (HP:0002505)1.92500632
108Adactyly (HP:0009776)1.92038895
109Hypoplasia of the ulna (HP:0003022)1.91550795
110Abnormal drinking behavior (HP:0030082)1.90936718
111Polydipsia (HP:0001959)1.90936718
112Cutaneous finger syndactyly (HP:0010554)1.90378371
113Protruding tongue (HP:0010808)1.89979689
114Polyuria (HP:0000103)1.89729924
115Morphological abnormality of the middle ear (HP:0008609)1.89202039
116Furrowed tongue (HP:0000221)1.88782013
117Visual hallucinations (HP:0002367)1.88770004
118Erythroderma (HP:0001019)1.88238380
119Nephroblastoma (Wilms tumor) (HP:0002667)1.88217511
120Acute necrotizing encephalopathy (HP:0006965)1.88148237
121Decreased circulating renin level (HP:0003351)1.87096534
122Poor coordination (HP:0002370)1.86884799
123Adrenal hypoplasia (HP:0000835)1.86788222
124Abnormal pancreas size (HP:0012094)1.86335095
125Nasolacrimal duct obstruction (HP:0000579)1.86284137
126Absent eyebrow (HP:0002223)1.85737661
127Congenital sensorineural hearing impairment (HP:0008527)1.85636446
128Abnormality of the 1st metacarpal (HP:0010009)1.85472875
129Abnormality of the fovea (HP:0000493)1.85407685
130Abnormality of the renal collecting system (HP:0004742)1.85264996
131Male pseudohermaphroditism (HP:0000037)1.85068403
132Abnormality of the nasolacrimal system (HP:0000614)1.84905522
133Absent speech (HP:0001344)1.84302918
134Concave nail (HP:0001598)1.83409204
135Atelectasis (HP:0100750)1.83245577
136Abnormal respiratory epithelium morphology (HP:0012253)1.83108978
137Abnormal respiratory motile cilium morphology (HP:0005938)1.83108978
138Anomalous pulmonary venous return (HP:0010772)1.82794181
139Abnormality of the nasal septum (HP:0000419)1.82428992
140Abnormality of the axillary hair (HP:0100134)1.82028770
141Abnormality of secondary sexual hair (HP:0009888)1.82028770
142Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81113441
143Abnormality of the neuromuscular junction (HP:0003398)1.79982907
144Fatigable weakness (HP:0003473)1.79982907
145Megalencephaly (HP:0001355)1.79887194
146Absent phalangeal crease (HP:0006109)1.79138235
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79091122
148Embryonal renal neoplasm (HP:0011794)1.77699221
149Abnormality of incisor morphology (HP:0011063)1.77435009
150Inability to walk (HP:0002540)1.76748927
151Popliteal pterygium (HP:0009756)1.76564659
152Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75493589
153Short 4th metacarpal (HP:0010044)1.75493589
154Aplasia/Hypoplasia of the fibula (HP:0006492)1.75113908
155Hypoplastic left heart (HP:0004383)1.75085173
156Hemiplegia (HP:0002301)1.74962406
157Preaxial hand polydactyly (HP:0001177)1.74955867
158Long nose (HP:0003189)1.74816239
159Anencephaly (HP:0002323)1.74637915
160Nephronophthisis (HP:0000090)1.74607971
161Astigmatism (HP:0000483)1.73918045
162Median cleft lip (HP:0000161)1.73633951
163Stenosis of the external auditory canal (HP:0000402)1.72734451
164Tubulointerstitial nephritis (HP:0001970)1.72567471
165Hypoplasia of the fovea (HP:0007750)1.72275582
166Aplasia/Hypoplasia of the fovea (HP:0008060)1.72275582
167Hemiparesis (HP:0001269)1.72120072
168Renal dysplasia (HP:0000110)1.70480250
169Abnormal respiratory motile cilium physiology (HP:0012261)1.70335758
170Metaphyseal dysplasia (HP:0100255)1.69925722
171Retinal dysplasia (HP:0007973)1.68300143
172Cutaneous syndactyly (HP:0012725)1.66886887
173Hypoplastic heart (HP:0001961)1.66131125
174Blue irides (HP:0000635)1.65641744
175Mediastinal lymphadenopathy (HP:0100721)1.65545688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.69799797
2FRK4.18537304
3NTRK33.65842032
4TNIK3.55127206
5MAP2K72.62908750
6GRK12.56144652
7TLK12.52541350
8PRPF4B2.33383246
9ADRBK22.01052397
10MAP4K21.99850484
11WNK41.97514608
12SIK31.85887738
13MAP3K41.82173750
14MAPK131.80684740
15AKT31.77802174
16MUSK1.72015048
17TNK21.71651082
18EPHA41.66995530
19INSRR1.62008216
20TAOK31.58348156
21MAP3K121.57736035
22GRK71.55986050
23SGK21.55373261
24DYRK21.50710841
25MKNK21.49179545
26TXK1.44346377
27BCKDK1.43444990
28BMPR21.37788657
29YES11.37352911
30MAPKAPK31.34816148
31RIPK41.32882894
32CDK31.31666142
33NEK61.30118873
34STK161.29620284
35NUAK11.29283048
36MAP3K91.24314643
37TIE11.23860692
38IRAK11.21373698
39CSNK1G21.21141214
40MAP3K141.21100478
41GRK51.20872146
42BMPR1B1.20501384
43SGK4941.19973702
44SGK2231.19973702
45ACVR1B1.17581853
46MAP3K131.15882661
47NTRK21.13699130
48PLK21.13677278
49PRKCE1.13065605
50MAPKAPK51.03597582
51IRAK21.03143294
52EIF2AK21.00129581
53OXSR10.96997980
54CAMK2A0.96632118
55MAP2K40.93976870
56MARK10.93445245
57IRAK30.91828154
58CDK80.90689205
59BCR0.86964307
60MINK10.86709238
61PRKCG0.86155913
62CAMKK20.84677183
63KIT0.83009324
64BLK0.81424920
65IRAK40.81282331
66FGFR20.81103097
67ERBB20.80996843
68WNK10.79683281
69ZAK0.78840491
70PKN10.78491008
71SIK20.77954847
72SGK30.76681622
73PINK10.74563987
74MKNK10.73873959
75SGK10.73751239
76PIK3CA0.72555719
77EPHB20.72461274
78FES0.71199011
79CAMK2B0.70208274
80CSNK1G10.69556507
81CSNK1G30.69202374
82PASK0.67450319
83WNK30.66397553
84CDK50.66240152
85IKBKB0.64711349
86FLT30.64405967
87KDR0.64270718
88CAMK2D0.63409700
89CAMK2G0.63226356
90PHKG20.62358481
91PHKG10.62358481
92TYRO30.60845277
93PAK30.60773722
94MST40.60119165
95PNCK0.59022927
96OBSCN0.57046078
97STK390.56643086
98LIMK10.56263665
99CAMK10.56225993
100RPS6KA60.56131640
101MAPK150.54438259
102ITK0.53896185
103PLK40.53802260
104RPS6KA50.53689074
105DAPK20.53515209
106NME10.53258058
107PRKG10.52416799
108EPHA30.52380475
109CDK190.52194980
110PRKACA0.51726105
111FER0.51517186
112MAPK70.49981144
113SYK0.49803642
114DYRK30.49453214
115PRKCZ0.49268204
116TGFBR10.48689194
117ADRBK10.47455897
118CAMKK10.44968580
119PRKACG0.43746294
120ABL20.43629393
121LCK0.43374908
122DYRK1A0.42981836
123MAP2K20.42850678
124CSNK1A1L0.42821154
125INSR0.42669251
126ERBB40.42666325
127GRK60.42328232
128CCNB10.42263235
129LYN0.41935148
130TEC0.41073158
131AURKA0.40899741
132PAK60.40242186
133UHMK10.37320328
134MAPK120.37217302
135FGR0.34595535
136PRKCQ0.33728574
137STK240.33714549
138TAOK20.33339304
139STK110.32842382
140CAMK40.31561407
141PRKCB0.31370101
142ERBB30.30782716
143MAP2K60.30435494
144PRKCA0.29642591
145CSNK1A10.29566087
146VRK10.29138600
147RPS6KB10.29131773

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.34965556
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62314442
3Taste transduction_Homo sapiens_hsa047422.58813273
4Morphine addiction_Homo sapiens_hsa050322.58509776
5Synaptic vesicle cycle_Homo sapiens_hsa047212.57271851
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31292578
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.31003022
8GABAergic synapse_Homo sapiens_hsa047272.28166017
9Glutamatergic synapse_Homo sapiens_hsa047242.26314244
10Phototransduction_Homo sapiens_hsa047442.20978627
11Serotonergic synapse_Homo sapiens_hsa047262.15668838
12Olfactory transduction_Homo sapiens_hsa047402.07666760
13Ribosome_Homo sapiens_hsa030102.05788715
14Nitrogen metabolism_Homo sapiens_hsa009102.05019580
15Collecting duct acid secretion_Homo sapiens_hsa049661.99444372
16Linoleic acid metabolism_Homo sapiens_hsa005911.99208164
17Circadian entrainment_Homo sapiens_hsa047131.98240639
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.89531878
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83924905
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83464872
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.74229228
22Long-term depression_Homo sapiens_hsa047301.63533018
23Salivary secretion_Homo sapiens_hsa049701.63224978
24Calcium signaling pathway_Homo sapiens_hsa040201.62064920
25Sulfur metabolism_Homo sapiens_hsa009201.60071149
26Amphetamine addiction_Homo sapiens_hsa050311.58577509
27Retinol metabolism_Homo sapiens_hsa008301.51889722
28Chemical carcinogenesis_Homo sapiens_hsa052041.50016058
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.49665062
30Cholinergic synapse_Homo sapiens_hsa047251.45326847
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45287013
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45102502
33Insulin secretion_Homo sapiens_hsa049111.43132776
34Tryptophan metabolism_Homo sapiens_hsa003801.41123057
35Long-term potentiation_Homo sapiens_hsa047201.40715336
36Cocaine addiction_Homo sapiens_hsa050301.39834930
37Dopaminergic synapse_Homo sapiens_hsa047281.38983037
38Rheumatoid arthritis_Homo sapiens_hsa053231.38209751
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32697915
40Axon guidance_Homo sapiens_hsa043601.28922877
41RNA polymerase_Homo sapiens_hsa030201.28175574
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24529257
43Butanoate metabolism_Homo sapiens_hsa006501.24039116
44Sphingolipid metabolism_Homo sapiens_hsa006001.23253585
45Histidine metabolism_Homo sapiens_hsa003401.22458970
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19234526
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17496808
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16030034
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15390107
50Primary immunodeficiency_Homo sapiens_hsa053401.14357914
51Gastric acid secretion_Homo sapiens_hsa049711.13721178
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08214858
53Renin secretion_Homo sapiens_hsa049241.07575122
54Oxytocin signaling pathway_Homo sapiens_hsa049211.07343808
55Sulfur relay system_Homo sapiens_hsa041221.07238577
56Oxidative phosphorylation_Homo sapiens_hsa001901.06264902
57Glycerolipid metabolism_Homo sapiens_hsa005611.06051830
58cAMP signaling pathway_Homo sapiens_hsa040241.04328427
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01873266
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.99888229
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99680127
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99576837
63Caffeine metabolism_Homo sapiens_hsa002320.96432496
64RNA degradation_Homo sapiens_hsa030180.95969341
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95783950
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94951809
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94183321
68Cardiac muscle contraction_Homo sapiens_hsa042600.92930330
69Basal transcription factors_Homo sapiens_hsa030220.92886115
70Ether lipid metabolism_Homo sapiens_hsa005650.91807251
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90936091
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90384426
73Type I diabetes mellitus_Homo sapiens_hsa049400.90051496
74Homologous recombination_Homo sapiens_hsa034400.89266048
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87797276
76Fat digestion and absorption_Homo sapiens_hsa049750.86023027
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84115799
78Protein export_Homo sapiens_hsa030600.83398086
79Ovarian steroidogenesis_Homo sapiens_hsa049130.82996659
80Graft-versus-host disease_Homo sapiens_hsa053320.79534709
81Basal cell carcinoma_Homo sapiens_hsa052170.76816912
82Vibrio cholerae infection_Homo sapiens_hsa051100.76510938
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74426563
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.74250456
85Type II diabetes mellitus_Homo sapiens_hsa049300.73660987
86Peroxisome_Homo sapiens_hsa041460.73466745
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71846035
88GnRH signaling pathway_Homo sapiens_hsa049120.71365009
89Phagosome_Homo sapiens_hsa041450.71307655
90Tyrosine metabolism_Homo sapiens_hsa003500.71227971
91Melanoma_Homo sapiens_hsa052180.71172826
92MAPK signaling pathway_Homo sapiens_hsa040100.71072998
93Hedgehog signaling pathway_Homo sapiens_hsa043400.70775677
94Mineral absorption_Homo sapiens_hsa049780.70679268
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70544497
96Alzheimers disease_Homo sapiens_hsa050100.70412565
97ErbB signaling pathway_Homo sapiens_hsa040120.70041663
98Ras signaling pathway_Homo sapiens_hsa040140.66859020
99Fanconi anemia pathway_Homo sapiens_hsa034600.65650228
100Autoimmune thyroid disease_Homo sapiens_hsa053200.65484284
101Regulation of autophagy_Homo sapiens_hsa041400.65288099
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65087202
103beta-Alanine metabolism_Homo sapiens_hsa004100.62690081
104African trypanosomiasis_Homo sapiens_hsa051430.62434690
105Pancreatic secretion_Homo sapiens_hsa049720.62226138
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61484246
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60449026
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59955315
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56097534
110Parkinsons disease_Homo sapiens_hsa050120.55584441
111Selenocompound metabolism_Homo sapiens_hsa004500.55507399
112Arachidonic acid metabolism_Homo sapiens_hsa005900.54837651
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54643291
114Inositol phosphate metabolism_Homo sapiens_hsa005620.54575784
115Dilated cardiomyopathy_Homo sapiens_hsa054140.52891703
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52583410
117Chemokine signaling pathway_Homo sapiens_hsa040620.52257755
118Melanogenesis_Homo sapiens_hsa049160.51140671
119Gap junction_Homo sapiens_hsa045400.50675933
120Choline metabolism in cancer_Homo sapiens_hsa052310.50017353
121Circadian rhythm_Homo sapiens_hsa047100.49945326
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49689819
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.48814079
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48511099
125Fatty acid elongation_Homo sapiens_hsa000620.48043145
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47349581
127Dorso-ventral axis formation_Homo sapiens_hsa043200.47119235
128Rap1 signaling pathway_Homo sapiens_hsa040150.46835851
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46173148
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46154986
131Metabolic pathways_Homo sapiens_hsa011000.45835320
132Propanoate metabolism_Homo sapiens_hsa006400.45581286
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44443808
134Allograft rejection_Homo sapiens_hsa053300.44126680
135Starch and sucrose metabolism_Homo sapiens_hsa005000.42968778
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41217035
137Wnt signaling pathway_Homo sapiens_hsa043100.39278177
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39207565
139ABC transporters_Homo sapiens_hsa020100.38539737
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.38484483
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.38018299
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.37387006
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37017812
144Huntingtons disease_Homo sapiens_hsa050160.36796399
145Hematopoietic cell lineage_Homo sapiens_hsa046400.36665823
146Asthma_Homo sapiens_hsa053100.36005208
147Estrogen signaling pathway_Homo sapiens_hsa049150.33520382
148Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32868418
149Purine metabolism_Homo sapiens_hsa002300.32846689
150Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31752912

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