PLD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.93829513
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.80847046
3synaptic vesicle exocytosis (GO:0016079)5.59075985
4synaptic vesicle maturation (GO:0016188)5.45652884
5glutamate secretion (GO:0014047)5.16836314
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.14813979
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.10823774
8regulation of synaptic vesicle exocytosis (GO:2000300)5.10149564
9vocalization behavior (GO:0071625)5.01212442
10glycosphingolipid catabolic process (GO:0046479)4.97267128
11locomotory exploration behavior (GO:0035641)4.93093653
12regulation of glutamate receptor signaling pathway (GO:1900449)4.86140621
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.69133058
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.59689769
15regulation of synaptic vesicle transport (GO:1902803)4.52305608
16glycolipid catabolic process (GO:0019377)4.44212263
17neurotransmitter-gated ion channel clustering (GO:0072578)4.42138697
18barbed-end actin filament capping (GO:0051016)4.36570150
19protein localization to synapse (GO:0035418)4.29703890
20amino sugar catabolic process (GO:0046348)4.19127719
21neurotransmitter secretion (GO:0007269)4.18415526
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.09371812
23oligosaccharide catabolic process (GO:0009313)4.07656424
24regulation of synapse structural plasticity (GO:0051823)4.03070131
25regulation of mononuclear cell migration (GO:0071675)4.01784747
26regulation of neuronal synaptic plasticity (GO:0048168)3.99413471
27neuron cell-cell adhesion (GO:0007158)3.96691069
28ceramide catabolic process (GO:0046514)3.94951567
29neuronal action potential propagation (GO:0019227)3.93432324
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.92946230
31synaptic transmission, glutamatergic (GO:0035249)3.76448437
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76295627
33transferrin transport (GO:0033572)3.74996233
34exploration behavior (GO:0035640)3.74236005
35proline transport (GO:0015824)3.72089426
36neuron-neuron synaptic transmission (GO:0007270)3.69773055
37regulation of cholesterol storage (GO:0010885)3.66240382
38long-term synaptic potentiation (GO:0060291)3.64485357
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.57250788
40cellular response to thyroid hormone stimulus (GO:0097067)3.56959657
41ATP hydrolysis coupled proton transport (GO:0015991)3.56446336
42energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.56446336
43positive regulation of neurotransmitter secretion (GO:0001956)3.54703037
44glutamate receptor signaling pathway (GO:0007215)3.53690406
45positive regulation of membrane potential (GO:0045838)3.53488453
46positive regulation of neurotransmitter transport (GO:0051590)3.52566739
47protein localization to endosome (GO:0036010)3.48552404
48ferric iron transport (GO:0015682)3.44913560
49trivalent inorganic cation transport (GO:0072512)3.44913560
50regulation of synaptic plasticity (GO:0048167)3.44508995
51membrane lipid catabolic process (GO:0046466)3.43819821
52sphingolipid catabolic process (GO:0030149)3.38940361
53response to histamine (GO:0034776)3.38810530
54regulation of postsynaptic membrane potential (GO:0060078)3.37400946
55adhesion of symbiont to host cell (GO:0044650)3.36935972
56virion attachment to host cell (GO:0019062)3.36935972
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.35250584
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33124984
59long-term memory (GO:0007616)3.32811441
60regulation of neurotransmitter secretion (GO:0046928)3.30654332
61activation of protein kinase A activity (GO:0034199)3.30299059
62response to auditory stimulus (GO:0010996)3.30074829
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28988186
64neurotransmitter transport (GO:0006836)3.27499250
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.27357995
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.24821881
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.24644452
68negative regulation of amino acid transport (GO:0051956)3.23214566
69synaptic vesicle endocytosis (GO:0048488)3.22819199
70G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.21221104
71postsynaptic membrane organization (GO:0001941)3.19589380
72negative regulation of interleukin-12 production (GO:0032695)3.18100034
73cellular potassium ion homeostasis (GO:0030007)3.18028509
74phagosome maturation (GO:0090382)3.17845012
75neuromuscular process controlling posture (GO:0050884)3.17603297
76positive regulation of synapse maturation (GO:0090129)3.16624771
77positive regulation of synaptic transmission (GO:0050806)3.14035161
78adhesion of symbiont to host (GO:0044406)3.12724080
79regulation of glutamate secretion (GO:0014048)3.12699920
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.09501068
81regulation of neurotransmitter levels (GO:0001505)3.08600999
82regulation of vesicle fusion (GO:0031338)3.08309494
83regulation of neurotransmitter transport (GO:0051588)3.07887976
84response to acidic pH (GO:0010447)3.05879391
85negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.05596567
86glial cell migration (GO:0008347)3.05481518
87apoptotic cell clearance (GO:0043277)3.05149421
88keratan sulfate catabolic process (GO:0042340)3.04956506
89presynaptic membrane assembly (GO:0097105)3.01713252
90gamma-aminobutyric acid transport (GO:0015812)3.01283721
91auditory behavior (GO:0031223)3.00828961
92response to peptidoglycan (GO:0032494)2.96469499
93regulation of female receptivity (GO:0045924)2.94587455
94mannose metabolic process (GO:0006013)2.92845610
95neuromuscular process controlling balance (GO:0050885)2.92345824
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91389058
97ganglioside metabolic process (GO:0001573)2.90465744
98negative regulation of nitric oxide biosynthetic process (GO:0045019)2.89067096
99regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88268815
100positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.86162684
101adenosine receptor signaling pathway (GO:0001973)2.86107131
102membrane depolarization (GO:0051899)2.85273457
103positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.85159957
104regulation of synaptic transmission (GO:0050804)2.84911294
105response to thyroid hormone (GO:0097066)2.82553749
106positive regulation of cholesterol efflux (GO:0010875)2.79521895
107female mating behavior (GO:0060180)2.79210973
108behavioral response to cocaine (GO:0048148)2.78151487
109layer formation in cerebral cortex (GO:0021819)2.77940490
110presynaptic membrane organization (GO:0097090)2.77889506
111regulation of voltage-gated calcium channel activity (GO:1901385)2.76815306
112negative regulation of dendrite morphogenesis (GO:0050774)2.75234266
113N-acetylneuraminate metabolic process (GO:0006054)2.74944046
114synaptic transmission (GO:0007268)2.74732973
115sodium ion export (GO:0071436)2.74079870
116positive regulation of heat generation (GO:0031652)2.73899896
117cerebellar Purkinje cell differentiation (GO:0021702)2.72484537
118membrane depolarization during action potential (GO:0086010)2.70967501
119positive regulation of vesicle fusion (GO:0031340)2.70774910
120regulation of exocytosis (GO:0017157)2.70684719
121regulation of macrophage chemotaxis (GO:0010758)2.70680973
122vesicle transport along microtubule (GO:0047496)2.70524442
123regulation of dendritic spine morphogenesis (GO:0061001)2.70120250
124mechanosensory behavior (GO:0007638)2.69719781
125dendritic spine morphogenesis (GO:0060997)2.69215362
126establishment of synaptic vesicle localization (GO:0097480)2.68983013
127synaptic vesicle transport (GO:0048489)2.68983013
128cerebellar Purkinje cell layer development (GO:0021680)2.66742539
129learning (GO:0007612)2.66532211
130neuron recognition (GO:0008038)2.64283393
131membrane hyperpolarization (GO:0060081)2.63949986
132protein retention in ER lumen (GO:0006621)2.63688101
133calcium ion-dependent exocytosis (GO:0017156)2.63510562
134L-amino acid import (GO:0043092)2.62580282
135positive regulation of monocyte chemotaxis (GO:0090026)2.61606715
136positive regulation of leukocyte degranulation (GO:0043302)2.60973305
137regulation of vitamin D biosynthetic process (GO:0060556)2.59773367
138cell-cell junction maintenance (GO:0045217)2.57847964
139low-density lipoprotein particle clearance (GO:0034383)2.57383885
140positive regulation of chemokine biosynthetic process (GO:0045080)2.56866315
141lipopolysaccharide-mediated signaling pathway (GO:0031663)2.54538924
142amyloid precursor protein catabolic process (GO:0042987)2.54221317
143lysosome organization (GO:0007040)2.51521199
144lytic vacuole organization (GO:0080171)2.51521199
145regulation of membrane protein ectodomain proteolysis (GO:0051043)2.51120596
146regulation of fever generation (GO:0031620)2.50228218
147branching involved in labyrinthine layer morphogenesis (GO:0060670)2.49791426
148negative regulation of erythrocyte differentiation (GO:0045647)2.49254896
149decidualization (GO:0046697)2.49143929
150regulation of early endosome to late endosome transport (GO:2000641)2.48796748
151neutrophil activation involved in immune response (GO:0002283)2.48285387
152regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.47822543
153regulation of podosome assembly (GO:0071801)2.47549310
154response to manganese ion (GO:0010042)2.46184138
155fat-soluble vitamin biosynthetic process (GO:0042362)2.44824390
156Golgi transport vesicle coating (GO:0048200)2.43132010
157COPI coating of Golgi vesicle (GO:0048205)2.43132010
158monocyte chemotaxis (GO:0002548)2.43026617
159maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.41011920
160glucose 6-phosphate metabolic process (GO:0051156)2.40094024
161bone resorption (GO:0045453)2.39410718
162regulation of T-helper 2 cell differentiation (GO:0045628)2.39241790
163regulation of leukocyte degranulation (GO:0043300)2.38869987
164activation of MAPKKK activity (GO:0000185)2.36848587
165regulation of monocyte chemotaxis (GO:0090025)2.34791741
166positive regulation of mast cell activation involved in immune response (GO:0033008)2.32858995
167positive regulation of mast cell degranulation (GO:0043306)2.32858995
168stress fiber assembly (GO:0043149)2.31957143
169macrophage activation involved in immune response (GO:0002281)2.31952921
170cytoskeletal anchoring at plasma membrane (GO:0007016)2.31622712
171epithelial cell differentiation involved in prostate gland development (GO:0060742)2.31132366
172chondroitin sulfate catabolic process (GO:0030207)2.30104792
173positive regulation of cellular amide metabolic process (GO:0034250)2.28264747
174regulation of mast cell degranulation (GO:0043304)2.28044207
175dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.24862849
176serine transport (GO:0032329)2.24749777
177regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.22343159
178cellular copper ion homeostasis (GO:0006878)2.22337555
179positive regulation of cholesterol transport (GO:0032376)2.22314547
180positive regulation of sterol transport (GO:0032373)2.22314547
181eosinophil chemotaxis (GO:0048245)2.21683535
182negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.21339577

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.91140175
2GBX2_23144817_ChIP-Seq_PC3_Human3.53484802
3NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.28223719
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10183122
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00073041
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.95146332
7IKZF1_21737484_ChIP-ChIP_HCT116_Human2.84591913
8LXR_22292898_ChIP-Seq_THP-1_Human2.75947439
9REST_21632747_ChIP-Seq_MESCs_Mouse2.74248121
10* RARB_27405468_Chip-Seq_BRAIN_Mouse2.71095479
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70184532
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66940747
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59887936
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55897999
15DROSHA_22980978_ChIP-Seq_HELA_Human2.49318732
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49003425
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49003425
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46476377
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45981311
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44686518
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44251550
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.43542281
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.33202703
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13419065
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.11692892
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.10185006
27KDM2B_26808549_Chip-Seq_SUP-B15_Human2.09871782
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.07583020
29ELK3_25401928_ChIP-Seq_HUVEC_Human2.02409759
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.99212764
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.94502253
32* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92908550
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90647026
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.87224358
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.83019494
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82692475
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81962080
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.80712352
39VDR_21846776_ChIP-Seq_THP-1_Human1.76054283
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75537653
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70562438
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70212834
43AR_21572438_ChIP-Seq_LNCaP_Human1.68889838
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64148239
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63867281
46* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62942914
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62683024
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.59942961
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59078730
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.58824627
51SMAD4_21799915_ChIP-Seq_A2780_Human1.57498249
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.55272767
53CLOCK_20551151_ChIP-Seq_293T_Human1.53872214
54TAF15_26573619_Chip-Seq_HEK293_Human1.53734368
55KDM2B_26808549_Chip-Seq_DND41_Human1.53322625
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48954218
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48062906
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47342861
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46202101
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39796761
61RACK7_27058665_Chip-Seq_MCF-7_Human1.39576851
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39473043
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37911761
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37680053
65* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35690250
66VDR_24763502_ChIP-Seq_THP-1_Human1.35646972
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34698228
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34320179
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33003052
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30982982
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27383212
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26995960
73P300_19829295_ChIP-Seq_ESCs_Human1.26425713
74AR_25329375_ChIP-Seq_VCAP_Human1.25730124
75SPI1_23127762_ChIP-Seq_K562_Human1.25514281
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24265010
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.23665216
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.22806956
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22562856
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22439698
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22183570
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20888486
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.20532118
84SMC4_20622854_ChIP-Seq_HELA_Human1.19017183
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.18447908
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.18439256
87P68_20966046_ChIP-Seq_HELA_Human1.17767524
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17124167
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16207575
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14783639
91CTCF_27219007_Chip-Seq_Bcells_Human1.13062878
92* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12979743
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12574261
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12331893
95ZNF263_19887448_ChIP-Seq_K562_Human1.12094143
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.10905752
97* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09793767
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09558882
99RXR_22108803_ChIP-Seq_LS180_Human1.09380334
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09095895
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08672744
102* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08342664
103AR_19668381_ChIP-Seq_PC3_Human1.07990810
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07751729
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07285374
106BCL6_27268052_Chip-Seq_Bcells_Human1.07005623
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06610518
108IRF8_22096565_ChIP-ChIP_GC-B_Human1.06542830
109EGR1_19374776_ChIP-ChIP_THP-1_Human1.06341189
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05594817
111TCF7_22412390_ChIP-Seq_EML_Mouse1.05400411
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05351376
113VDR_24787735_ChIP-Seq_THP-1_Human1.04932047
114TRIM28_21343339_ChIP-Seq_HEK293_Human1.04592275
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04375008
116PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04194845
117TP63_17297297_ChIP-ChIP_HaCaT_Human1.04089644
118AHR_22903824_ChIP-Seq_MCF-7_Human1.03768065
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.03681962
120* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02715288
121BCOR_27268052_Chip-Seq_Bcells_Human1.01650514
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01618851
123IRF8_21731497_ChIP-ChIP_J774_Mouse1.01099215
124STAT3_23295773_ChIP-Seq_U87_Human0.99916788
125RING1B_27294783_Chip-Seq_ESCs_Mouse0.99796965
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99548414
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99349540
128BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99220570
129PRDM14_20953172_ChIP-Seq_ESCs_Human0.99160431
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.98714277
131P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98617655
132CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98341671
133SA1_27219007_Chip-Seq_Bcells_Human0.98331266
134TP53_20018659_ChIP-ChIP_R1E_Mouse0.97744407
135FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96966391
136ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96444654
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95822837
138TP53_22127205_ChIP-Seq_IMR90_Human0.94749053
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94556031
140SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94459227
141SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94345472
142KDM2B_26808549_Chip-Seq_K562_Human0.94175757
143TCF4_23295773_ChIP-Seq_U87_Human0.94105788
144RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91968153
145SMAD3_21741376_ChIP-Seq_ESCs_Human0.91535856
146RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90960716
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87880398
148WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86317081
149TP53_18474530_ChIP-ChIP_U2OS_Human0.84143624
150RUNX2_22187159_ChIP-Seq_PCA_Human0.83593141
151YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82942538
152SMAD3_21741376_ChIP-Seq_HESCs_Human0.82512615
153Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82512052
154BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82345823
155SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81256543
156ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80848611
157NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80734321
158NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80734321
159SMAD4_21741376_ChIP-Seq_HESCs_Human0.80302832
160JUN_21703547_ChIP-Seq_K562_Human0.79494391
161TET1_21490601_ChIP-Seq_MESCs_Mouse0.79166168
162BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76043213
163AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75922873
164ER_23166858_ChIP-Seq_MCF-7_Human0.74843188
165UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.74791394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.39086350
2MP0003880_abnormal_central_pattern4.66911037
3MP0003635_abnormal_synaptic_transmissio3.99508726
4MP0009840_abnormal_foam_cell3.98349284
5MP0009745_abnormal_behavioral_response3.38017741
6MP0002064_seizures3.37357991
7MP0002063_abnormal_learning/memory/cond3.24022671
8MP0009046_muscle_twitch3.18587651
9MP0002822_catalepsy3.17580016
10MP0004270_analgesia3.17377899
11MP0001968_abnormal_touch/_nociception3.10593429
12MP0002572_abnormal_emotion/affect_behav2.78516567
13MP0002736_abnormal_nociception_after2.66904043
14MP0001501_abnormal_sleep_pattern2.51580374
15MP0009780_abnormal_chondrocyte_physiolo2.39804006
16MP0002734_abnormal_mechanical_nocicepti2.39404661
17MP0000343_altered_response_to2.38529687
18MP0003191_abnormal_cellular_cholesterol2.31545807
19MP0002272_abnormal_nervous_system2.30293746
20MP0001486_abnormal_startle_reflex2.14179680
21MP0003436_decreased_susceptibility_to2.09752325
22MP0003879_abnormal_hair_cell2.09315214
23MP0009278_abnormal_bone_marrow2.08921835
24MP0002735_abnormal_chemical_nociception2.07820582
25MP0004858_abnormal_nervous_system2.05826768
26MP0002909_abnormal_adrenal_gland1.96736005
27MP0005423_abnormal_somatic_nervous1.96348349
28MP0001440_abnormal_grooming_behavior1.95545065
29MP0003300_gastrointestinal_ulcer1.93387488
30MP0001970_abnormal_pain_threshold1.90780421
31MP0005257_abnormal_intraocular_pressure1.89841256
32MP0005646_abnormal_pituitary_gland1.88989965
33MP0002733_abnormal_thermal_nociception1.88670046
34MP0002139_abnormal_hepatobiliary_system1.86806284
35MP0008438_abnormal_cutaneous_collagen1.85239426
36MP0003172_abnormal_lysosome_physiology1.83648424
37MP0003329_amyloid_beta_deposits1.80898362
38MP0002254_reproductive_system_inflammat1.78936723
39MP0002067_abnormal_sensory_capabilities1.77285288
40MP0005058_abnormal_lysosome_morphology1.74659393
41MP0008569_lethality_at_weaning1.69789213
42MP0003183_abnormal_peptide_metabolism1.65505952
43MP0004811_abnormal_neuron_physiology1.65502254
44MP0003279_aneurysm1.59988835
45MP0003724_increased_susceptibility_to1.59213561
46MP0006054_spinal_hemorrhage1.58603098
47MP0010386_abnormal_urinary_bladder1.56782460
48MP0001533_abnormal_skeleton_physiology1.55786963
49MP0005386_behavior/neurological_phenoty1.55666284
50MP0004924_abnormal_behavior1.55666284
51MP0003633_abnormal_nervous_system1.55427087
52MP0003075_altered_response_to1.54817095
53MP0002557_abnormal_social/conspecific_i1.52476363
54MP0005451_abnormal_body_composition1.51477926
55MP0005645_abnormal_hypothalamus_physiol1.46677136
56MP0000013_abnormal_adipose_tissue1.42471857
57MP0009764_decreased_sensitivity_to1.41827815
58MP0003690_abnormal_glial_cell1.40615690
59MP0009785_altered_susceptibility_to1.39650894
60MP0003122_maternal_imprinting1.39100413
61MP0000604_amyloidosis1.38903913
62MP0001542_abnormal_bone_strength1.34273375
63MP0004510_myositis1.32378164
64MP0002184_abnormal_innervation1.32314266
65MP0003787_abnormal_imprinting1.31713514
66MP0001502_abnormal_circadian_rhythm1.28617009
67MP0001529_abnormal_vocalization1.26901144
68MP0002066_abnormal_motor_capabilities/c1.24209935
69MP0001984_abnormal_olfaction1.23804769
70MP0006276_abnormal_autonomic_nervous1.21631598
71MP0005025_abnormal_response_to1.21170487
72MP0003453_abnormal_keratinocyte_physiol1.20454752
73MP0005397_hematopoietic_system_phenotyp1.18193630
74MP0001545_abnormal_hematopoietic_system1.18193630
75MP0001905_abnormal_dopamine_level1.18005918
76MP0002090_abnormal_vision1.17437369
77MP0003631_nervous_system_phenotype1.14618659
78MP0001958_emphysema1.13068923
79MP0001849_ear_inflammation1.12513089
80MP0005000_abnormal_immune_tolerance1.11582025
81MP0000955_abnormal_spinal_cord1.10606766
82MP0003303_peritoneal_inflammation1.09061052
83MP0002882_abnormal_neuron_morphology1.09057486
84MP0003705_abnormal_hypodermis_morpholog1.08787701
85MP0003448_altered_tumor_morphology1.07292833
86MP0000858_altered_metastatic_potential1.06822222
87MP0000569_abnormal_digit_pigmentation1.05144363
88MP0005167_abnormal_blood-brain_barrier1.04034403
89MP0008961_abnormal_basal_metabolism1.02967861
90MP0000778_abnormal_nervous_system1.01135476
91MP0001853_heart_inflammation1.00969941
92MP0003091_abnormal_cell_migration1.00333297
93MP0005310_abnormal_salivary_gland0.98065272
94MP0005387_immune_system_phenotype0.96886615
95MP0001790_abnormal_immune_system0.96886615
96MP0005535_abnormal_body_temperature0.96782047
97MP0008874_decreased_physiological_sensi0.96754050
98MP0005595_abnormal_vascular_smooth0.96735495
99MP0004142_abnormal_muscle_tone0.95452157
100MP0003634_abnormal_glial_cell0.94922176
101MP0008872_abnormal_physiological_respon0.94645393
102MP0005390_skeleton_phenotype0.94463730
103MP0002653_abnormal_ependyma_morphology0.94044312
104MP0002069_abnormal_eating/drinking_beha0.92267700
105MP0005165_increased_susceptibility_to0.91858041
106MP0002876_abnormal_thyroid_physiology0.91273908
107MP0002295_abnormal_pulmonary_circulatio0.91227240
108MP0004947_skin_inflammation0.91199599
109MP0005166_decreased_susceptibility_to0.89985178
110MP0002896_abnormal_bone_mineralization0.89067956
111MP0000747_muscle_weakness0.88489448
112MP0008469_abnormal_protein_level0.87736901
113MP0008004_abnormal_stomach_pH0.87404551
114MP0002229_neurodegeneration0.84860980
115MP0002332_abnormal_exercise_endurance0.81224916
116MP0000751_myopathy0.79755320
117MP0002452_abnormal_antigen_presenting0.79358121
118MP0001845_abnormal_inflammatory_respons0.78436029
119MP0006082_CNS_inflammation0.76617844
120MP0000750_abnormal_muscle_regeneration0.76527382
121MP0005671_abnormal_response_to0.75211042
122MP0001664_abnormal_digestion0.75031963
123MP0001177_atelectasis0.74479118
124MP0000920_abnormal_myelination0.73221194
125MP0003795_abnormal_bone_structure0.71612609
126MP0005464_abnormal_platelet_physiology0.70353032
127MP0004885_abnormal_endolymph0.70220794
128MP0002152_abnormal_brain_morphology0.69853750
129MP0005508_abnormal_skeleton_morphology0.68874290
130MP0002723_abnormal_immune_serum0.67394954
131MP0001835_abnormal_antigen_presentation0.65481005
132MP0003632_abnormal_nervous_system0.62026578
133MP0003566_abnormal_cell_adhesion0.61064036
134MP0001963_abnormal_hearing_physiology0.60229966
135MP0004085_abnormal_heartbeat0.59887074
136MP0004130_abnormal_muscle_cell0.58876403
137MP0008260_abnormal_autophagy0.58423936
138MP0002837_dystrophic_cardiac_calcinosis0.58348955
139MP0001188_hyperpigmentation0.53613696
140MP0004742_abnormal_vestibular_system0.52981642
141MP0005448_abnormal_energy_balance0.51926328
142MP0004484_altered_response_of0.50228958
143MP0002998_abnormal_bone_remodeling0.49731227
144MP0005551_abnormal_eye_electrophysiolog0.48846017
145MP0003045_fibrosis0.46175803
146MP0001765_abnormal_ion_homeostasis0.45064602
147MP0005623_abnormal_meninges_morphology0.43941836
148MP0000681_abnormal_thyroid_gland0.41705826
149MP0004043_abnormal_pH_regulation0.41514909
150MP0002419_abnormal_innate_immunity0.40816389
151MP0004233_abnormal_muscle_weight0.40711857
152MP0002148_abnormal_hypersensitivity_rea0.40547542

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.56205502
2Myokymia (HP:0002411)6.27868847
3Focal seizures (HP:0007359)5.45835556
4Vacuolated lymphocytes (HP:0001922)5.24862247
5Epileptic encephalopathy (HP:0200134)5.00035854
6Atonic seizures (HP:0010819)4.96729964
7Visual hallucinations (HP:0002367)4.84416581
8Systemic lupus erythematosus (HP:0002725)4.39244273
9Febrile seizures (HP:0002373)4.28021572
10Absence seizures (HP:0002121)4.20161250
11Disinhibition (HP:0000734)4.16781904
12Dialeptic seizures (HP:0011146)3.98198186
13Generalized tonic-clonic seizures (HP:0002069)3.96492967
14Nuclear cataract (HP:0100018)3.82968559
15Increased cerebral lipofuscin (HP:0011813)3.76283988
16Supranuclear gaze palsy (HP:0000605)3.76120418
17Axonal loss (HP:0003447)3.66413447
18Abnormal eating behavior (HP:0100738)3.50408798
19Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.44245443
20Progressive cerebellar ataxia (HP:0002073)3.41195876
21Mutism (HP:0002300)3.28883309
22Abnormality of macrophages (HP:0004311)3.25153030
23Action tremor (HP:0002345)3.17525909
24Depression (HP:0000716)3.15509484
25Hyperventilation (HP:0002883)3.12277534
26Polyphagia (HP:0002591)3.11079144
27Abnormality of glycolipid metabolism (HP:0010969)3.06196339
28Abnormality of liposaccharide metabolism (HP:0010968)3.06196339
29Abnormality of glycosphingolipid metabolism (HP:0004343)3.06196339
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.98688329
31Ankle clonus (HP:0011448)2.97092436
32Broad-based gait (HP:0002136)2.96723233
33Poor eye contact (HP:0000817)2.92308853
34Impaired vibration sensation in the lower limbs (HP:0002166)2.91445458
35Diplopia (HP:0000651)2.88608896
36Abnormality of binocular vision (HP:0011514)2.88608896
37Anxiety (HP:0000739)2.88042983
38Postural instability (HP:0002172)2.80270265
39Upper motor neuron abnormality (HP:0002127)2.78842327
40Gaze-evoked nystagmus (HP:0000640)2.76067547
41Dysostosis multiplex (HP:0000943)2.75236102
42Urinary bladder sphincter dysfunction (HP:0002839)2.73278236
43Torticollis (HP:0000473)2.70718903
44Amyloidosis (HP:0011034)2.66221573
45Impaired social interactions (HP:0000735)2.66218676
46Abnormal social behavior (HP:0012433)2.66218676
47Truncal ataxia (HP:0002078)2.65920478
48Neuronal loss in central nervous system (HP:0002529)2.65169510
49Neurofibrillary tangles (HP:0002185)2.64504938
50Dysdiadochokinesis (HP:0002075)2.62518960
51Vertebral compression fractures (HP:0002953)2.62320316
52Failure to thrive in infancy (HP:0001531)2.57170393
53Cerebral inclusion bodies (HP:0100314)2.56106526
54Progressive neurologic deterioration (HP:0002344)2.54888925
55Amblyopia (HP:0000646)2.53970860
56Pheochromocytoma (HP:0002666)2.50975711
57Dysmetria (HP:0001310)2.49510643
58Glomerulonephritis (HP:0000099)2.47565105
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.47424880
60Focal dystonia (HP:0004373)2.47221133
61Upper limb amyotrophy (HP:0009129)2.47205958
62Distal upper limb amyotrophy (HP:0007149)2.47205958
63Hand muscle atrophy (HP:0009130)2.43902823
64Resting tremor (HP:0002322)2.42010148
65Stereotypic behavior (HP:0000733)2.39966496
66Papilledema (HP:0001085)2.38534336
67Premature rupture of membranes (HP:0001788)2.38186536
68Progressive inability to walk (HP:0002505)2.37294610
69Agnosia (HP:0010524)2.35773963
70Impaired smooth pursuit (HP:0007772)2.34689099
71Bradykinesia (HP:0002067)2.34669975
72Interstitial pulmonary disease (HP:0006530)2.34624022
73Neuroendocrine neoplasm (HP:0100634)2.30742487
74Personality changes (HP:0000751)2.30344919
75Myocardial infarction (HP:0001658)2.28497375
76Abnormality of the lower motor neuron (HP:0002366)2.27032349
77Epileptiform EEG discharges (HP:0011182)2.24410797
78Cerebral aneurysm (HP:0004944)2.23346894
79Asymmetric septal hypertrophy (HP:0001670)2.23138070
80Dysmetric saccades (HP:0000641)2.22048393
81Craniofacial dystonia (HP:0012179)2.20335989
82Abnormal hair whorl (HP:0010721)2.17847273
83Status epilepticus (HP:0002133)2.17737375
84Complement deficiency (HP:0004431)2.16894387
85Drooling (HP:0002307)2.14934852
86Excessive salivation (HP:0003781)2.14934852
87Prolonged neonatal jaundice (HP:0006579)2.14750278
88Agitation (HP:0000713)2.13549555
89Purpura (HP:0000979)2.11333932
90Abnormality of ocular smooth pursuit (HP:0000617)2.10940273
91Hemiplegia (HP:0002301)2.10375418
92Spinal canal stenosis (HP:0003416)2.10249075
93Loss of speech (HP:0002371)2.10127401
94Generalized myoclonic seizures (HP:0002123)2.10094149
95Pathologic fracture (HP:0002756)2.09182720
96Apathy (HP:0000741)2.08507390
97Impaired vibratory sensation (HP:0002495)2.08355047
98Urinary glycosaminoglycan excretion (HP:0003541)2.07892239
99Mucopolysacchariduria (HP:0008155)2.07892239
100Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.06416678
101Hypoventilation (HP:0002791)2.05796582
102Hemiparesis (HP:0001269)2.05744351
103Inappropriate behavior (HP:0000719)2.05636692
104Retinal atrophy (HP:0001105)2.03709766
105Oligomenorrhea (HP:0000876)2.03335928
106Inability to walk (HP:0002540)2.03314531
107Recurrent bacterial skin infections (HP:0005406)2.03253158
108Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02658997
109Abnormality of polysaccharide metabolism (HP:0011012)2.02658997
110Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02658997
111Eczematoid dermatitis (HP:0000976)2.02502719
112Urinary urgency (HP:0000012)2.02401147
113J-shaped sella turcica (HP:0002680)2.01776308
114EEG with generalized epileptiform discharges (HP:0011198)2.01463869
115Abnormality of the periventricular white matter (HP:0002518)2.01195806
116Recurrent abscess formation (HP:0002722)2.00753867
117Abnormality of the vasculature of the conjunctiva (HP:0008054)1.99940492
118Dementia (HP:0000726)1.98884395
119Psychosis (HP:0000709)1.98871773
120Rigidity (HP:0002063)1.97812687
121Menstrual irregularities (HP:0000858)1.96963461
122Genetic anticipation (HP:0003743)1.95407604
123Autoimmune thrombocytopenia (HP:0001973)1.93904671
124Fetal akinesia sequence (HP:0001989)1.91165558
125Diminished motivation (HP:0000745)1.90948102
126Cervical subluxation (HP:0003308)1.90863175
127Hypercortisolism (HP:0001578)1.90755641
128Spastic gait (HP:0002064)1.90157236
129Annular pancreas (HP:0001734)1.90050464
130Abnormal gallbladder physiology (HP:0012438)1.89892649
131Cholecystitis (HP:0001082)1.89892649
132Peripheral demyelination (HP:0011096)1.89597876
133Gait ataxia (HP:0002066)1.88866039
134Hypsarrhythmia (HP:0002521)1.88762658
135Abnormal neuron morphology (HP:0012757)1.86618954
136Abnormality of the motor neurons (HP:0002450)1.86618954
137Abnormality of complement system (HP:0005339)1.85555559
138Joint stiffness (HP:0001387)1.85548355
139Thoracic kyphosis (HP:0002942)1.85306758
140Limb dystonia (HP:0002451)1.85175618
141Ventricular fibrillation (HP:0001663)1.84753464
142Metaphyseal irregularity (HP:0003025)1.82586716
143Rapidly progressive (HP:0003678)1.81142072
144Achilles tendon contracture (HP:0001771)1.80571595
145Hepatosplenomegaly (HP:0001433)1.79870676
146Urinary incontinence (HP:0000020)1.79232085
147Cardiomegaly (HP:0001640)1.77822904
148Bone pain (HP:0002653)1.73106494
149Recurrent gram-negative bacterial infections (HP:0005420)1.71146615
150Thin bony cortex (HP:0002753)1.65282721
151Mediastinal lymphadenopathy (HP:0100721)1.64835088
152Increased serum ferritin (HP:0003281)1.63539716
153Turricephaly (HP:0000262)1.60254312
154Global brain atrophy (HP:0002283)1.60019752
155Memory impairment (HP:0002354)1.59516580
156Xanthomatosis (HP:0000991)1.59504140
157Hematochezia (HP:0002573)1.56110164
158Delusions (HP:0000746)1.55309526
159Hammertoe (HP:0001765)1.55152185
160Abnormality of the Achilles tendon (HP:0005109)1.54914293
161Protuberant abdomen (HP:0001538)1.54738222
162Hyperacusis (HP:0010780)1.53769149
163Distal lower limb amyotrophy (HP:0008944)1.52947765
164Mesangial abnormality (HP:0001966)1.51161824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.46407253
2NTRK34.00116191
3MAP3K93.50558136
4DAPK23.48058346
5CASK3.33454464
6MAP3K123.07857655
7RIPK42.85563854
8IRAK32.84064575
9TESK12.83602660
10DDR22.63311152
11NME22.59528524
12RIPK12.58165490
13MAP3K42.57856521
14MAP2K72.53629560
15MAP3K112.44167294
16DAPK12.36757759
17ARAF2.19089238
18MINK12.12756157
19KSR22.08759206
20CDK192.04501604
21PIM22.01146919
22ERN12.00247245
23CAMKK11.98813490
24LIMK11.98713768
25PAK61.94690928
26PLK21.94635397
27TESK21.87456426
28TAOK21.85531442
29PRKD31.84743153
30TGFBR21.84575514
31PRPF4B1.80515147
32TRIB31.65597030
33NTRK21.63672717
34CAMKK21.61503148
35NTRK11.61109831
36MAP2K41.60824901
37GRK51.58634816
38MAP3K131.52642238
39MARK11.52327185
40MATK1.51261616
41BLK1.50981349
42TBK11.47680652
43ABL21.44968358
44EPHB21.43320583
45CDK51.42359973
46FES1.41592543
47CDC42BPA1.29452788
48KSR11.27530621
49MAP3K21.27088260
50PDGFRA1.26868468
51CAMK1D1.26170313
52ICK1.21682027
53CCNB11.20173926
54PRKCG1.19478802
55PRKCH1.18652605
56MAP3K31.16961128
57AKT31.14558686
58LATS21.12163701
59PTK2B1.06987730
60MARK21.06670837
61SIK31.06325273
62BMPR21.04132842
63STK381.03085999
64PAK41.03048685
65EPHA31.01233674
66TAOK10.99265574
67SIK20.95808580
68DYRK1B0.95573677
69DAPK30.93374901
70SIK10.91783613
71MAP3K140.91051195
72BCKDK0.90955473
73CAMK2A0.90915523
74EPHB10.85512128
75MAP3K10.84620331
76SGK2230.81569494
77SGK4940.81569494
78TYK20.81032706
79OXSR10.80676830
80CDK180.80582303
81SGK20.80343286
82CAMK10.77922870
83SGK30.76707514
84RAF10.76355648
85CDK150.75657448
86PDK10.75605378
87MAP3K50.74596048
88CSNK1G30.73589583
89MAPK130.73509473
90PDPK10.73437901
91BRAF0.72874346
92CDK140.72060803
93TNK20.71655785
94CSK0.70500183
95CSNK1G20.70276425
96PRKD20.67642421
97CAMK2B0.66099790
98CSNK1A1L0.65623475
99FGR0.65505680
100MAP2K30.64668212
101CDK11A0.63472111
102RET0.62199785
103UHMK10.60667065
104STK110.58231093
105CAMK1G0.57744635
106MAP3K60.57664013
107ZAP700.57558580
108PRKCE0.57480394
109TTN0.57418790
110SGK10.56362899
111CSF1R0.55593447
112PKN10.53357719
113TYRO30.53317679
114MAP2K10.52779112
115TNIK0.52606720
116GRK70.52393049
117MAPK40.52151628
118IKBKB0.50968057
119FYN0.50386366
120MOS0.49365031
121NME10.48605320
122RPS6KC10.47761325
123RPS6KL10.47761325
124MAP2K60.47010838
125PINK10.46758717
126WNK30.46139375
127JAK10.45524087
128SYK0.44399756
129IRAK20.44333150
130JAK20.42770874
131TSSK60.42211093
132CAMK40.41729264
133ALK0.41579741
134FER0.40596993
135RPS6KA20.40276584
136ADRBK20.36610070
137NEK60.36332412
138RPS6KA30.35498781
139CAMK2G0.34563558
140MAPK70.34514253
141PRKCZ0.33462518
142BMX0.33375428
143ADRBK10.33147527
144LMTK20.32833788
145PAK30.32802947
146SCYL20.31639365
147CAMK2D0.30981035
148PRKCA0.30039571
149DYRK1A0.27645290
150PDK20.27200358
151PHKG20.27149176
152PHKG10.27149176
153PRKCB0.26332858

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.11470053
2Nicotine addiction_Homo sapiens_hsa050333.20165362
3Collecting duct acid secretion_Homo sapiens_hsa049663.07440451
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.94460934
5Olfactory transduction_Homo sapiens_hsa047402.67286461
6GABAergic synapse_Homo sapiens_hsa047272.34900333
7Circadian entrainment_Homo sapiens_hsa047132.31550093
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30083378
9Morphine addiction_Homo sapiens_hsa050322.29171776
10Long-term potentiation_Homo sapiens_hsa047202.19108063
11Amphetamine addiction_Homo sapiens_hsa050312.17435952
12Glutamatergic synapse_Homo sapiens_hsa047241.99431997
13Vibrio cholerae infection_Homo sapiens_hsa051101.98337472
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96387133
15Insulin secretion_Homo sapiens_hsa049111.85782076
16Salivary secretion_Homo sapiens_hsa049701.84657895
17Dopaminergic synapse_Homo sapiens_hsa047281.80574800
18Staphylococcus aureus infection_Homo sapiens_hsa051501.70907261
19Gastric acid secretion_Homo sapiens_hsa049711.63940149
20Cholinergic synapse_Homo sapiens_hsa047251.61007713
21Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.54953038
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53532194
23Renin secretion_Homo sapiens_hsa049241.50432769
24Cocaine addiction_Homo sapiens_hsa050301.48586171
25Rheumatoid arthritis_Homo sapiens_hsa053231.48586014
26Oxytocin signaling pathway_Homo sapiens_hsa049211.39731088
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38951137
28Calcium signaling pathway_Homo sapiens_hsa040201.38338467
29Lysosome_Homo sapiens_hsa041421.36584038
30Taste transduction_Homo sapiens_hsa047421.35840396
31Serotonergic synapse_Homo sapiens_hsa047261.34805813
32Long-term depression_Homo sapiens_hsa047301.29832214
33Malaria_Homo sapiens_hsa051441.29644254
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26920805
35Leishmaniasis_Homo sapiens_hsa051401.21955199
36Galactose metabolism_Homo sapiens_hsa000521.20200473
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19969619
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18545231
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18227482
40Type I diabetes mellitus_Homo sapiens_hsa049401.18054220
41GnRH signaling pathway_Homo sapiens_hsa049121.14507289
42Phagosome_Homo sapiens_hsa041451.14092300
43Type II diabetes mellitus_Homo sapiens_hsa049301.12688390
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11633115
45TNF signaling pathway_Homo sapiens_hsa046681.09943574
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08119403
47Sphingolipid metabolism_Homo sapiens_hsa006001.05431748
48cAMP signaling pathway_Homo sapiens_hsa040241.04349068
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03122909
50Gap junction_Homo sapiens_hsa045401.02828934
51Amoebiasis_Homo sapiens_hsa051461.02744015
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98095419
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97754795
54Glioma_Homo sapiens_hsa052140.96202637
55Legionellosis_Homo sapiens_hsa051340.92690261
56Estrogen signaling pathway_Homo sapiens_hsa049150.87889946
57Toxoplasmosis_Homo sapiens_hsa051450.86003012
58Bladder cancer_Homo sapiens_hsa052190.85767605
59Shigellosis_Homo sapiens_hsa051310.85702300
60Tuberculosis_Homo sapiens_hsa051520.82666828
61Fructose and mannose metabolism_Homo sapiens_hsa000510.82341595
62ErbB signaling pathway_Homo sapiens_hsa040120.80840396
63Asthma_Homo sapiens_hsa053100.80155516
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77468967
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76885231
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75470952
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.75174085
68Pancreatic secretion_Homo sapiens_hsa049720.73513320
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72802977
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.71554660
71Prion diseases_Homo sapiens_hsa050200.69288017
72Complement and coagulation cascades_Homo sapiens_hsa046100.68915376
73Mineral absorption_Homo sapiens_hsa049780.68099545
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.67998009
75Melanogenesis_Homo sapiens_hsa049160.67828469
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.67816697
77Notch signaling pathway_Homo sapiens_hsa043300.67383155
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67117148
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66975746
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66742290
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.66080438
82Endocytosis_Homo sapiens_hsa041440.65986716
83PPAR signaling pathway_Homo sapiens_hsa033200.64952744
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64923355
85Chemokine signaling pathway_Homo sapiens_hsa040620.63060513
86Axon guidance_Homo sapiens_hsa043600.62592318
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62066919
88MAPK signaling pathway_Homo sapiens_hsa040100.60778294
89Dilated cardiomyopathy_Homo sapiens_hsa054140.58227134
90Pentose phosphate pathway_Homo sapiens_hsa000300.57584014
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56011833
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55087119
93Dorso-ventral axis formation_Homo sapiens_hsa043200.55067037
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54840839
95Allograft rejection_Homo sapiens_hsa053300.54542950
96African trypanosomiasis_Homo sapiens_hsa051430.54499697
97Hepatitis C_Homo sapiens_hsa051600.54218461
98Thyroid hormone synthesis_Homo sapiens_hsa049180.53202029
99Cardiac muscle contraction_Homo sapiens_hsa042600.52362779
100Other glycan degradation_Homo sapiens_hsa005110.52322770
101Salmonella infection_Homo sapiens_hsa051320.52018539
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.50170600
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49983350
104VEGF signaling pathway_Homo sapiens_hsa043700.48766108
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.48144481
106Apoptosis_Homo sapiens_hsa042100.47523266
107Ras signaling pathway_Homo sapiens_hsa040140.47234197
108Phototransduction_Homo sapiens_hsa047440.46157173
109Osteoclast differentiation_Homo sapiens_hsa043800.45926976
110Rap1 signaling pathway_Homo sapiens_hsa040150.45851165
111Viral myocarditis_Homo sapiens_hsa054160.45396023
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44588815
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44549738
114Influenza A_Homo sapiens_hsa051640.44053139
115Inositol phosphate metabolism_Homo sapiens_hsa005620.43713276
116Choline metabolism in cancer_Homo sapiens_hsa052310.42715885
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.41167853
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41136376
119Antigen processing and presentation_Homo sapiens_hsa046120.41132983
120Oxidative phosphorylation_Homo sapiens_hsa001900.40375855
121Acute myeloid leukemia_Homo sapiens_hsa052210.40149185
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40034976
123mTOR signaling pathway_Homo sapiens_hsa041500.39868224
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.39802372
125Steroid biosynthesis_Homo sapiens_hsa001000.38160866
126Prolactin signaling pathway_Homo sapiens_hsa049170.38100213
127HIF-1 signaling pathway_Homo sapiens_hsa040660.37189108
128Oocyte meiosis_Homo sapiens_hsa041140.36756457
129Pertussis_Homo sapiens_hsa051330.36585578
130Regulation of autophagy_Homo sapiens_hsa041400.36258999
131Sulfur metabolism_Homo sapiens_hsa009200.35397424
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34403335
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34054894
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33288707
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32764941
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32682298
137Glucagon signaling pathway_Homo sapiens_hsa049220.32520304
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.32405281
139Circadian rhythm_Homo sapiens_hsa047100.31826139
140Renal cell carcinoma_Homo sapiens_hsa052110.31399290
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31314654
142Alzheimers disease_Homo sapiens_hsa050100.30796283
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30624028
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29264670

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