PLCXD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is the most terminal protein-coding gene in the pseudoautosomal (PAR) region on chromosomes X and Y. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.71603344
2regulation of gene silencing by RNA (GO:0060966)5.68532007
3regulation of posttranscriptional gene silencing (GO:0060147)5.68532007
4regulation of gene silencing by miRNA (GO:0060964)5.68532007
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.53205455
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.49940926
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.36858632
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11027854
9synaptic vesicle exocytosis (GO:0016079)5.05776819
10neuron cell-cell adhesion (GO:0007158)4.98881882
11neuronal action potential propagation (GO:0019227)4.88288592
12regulation of glutamate receptor signaling pathway (GO:1900449)4.73614268
13protein localization to synapse (GO:0035418)4.65864704
14glutamate secretion (GO:0014047)4.64398264
15regulation of synaptic vesicle exocytosis (GO:2000300)4.55369368
16synaptic vesicle maturation (GO:0016188)4.54581465
17positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.43057549
18neuromuscular process controlling posture (GO:0050884)4.38542188
19neurotransmitter secretion (GO:0007269)4.31000160
20locomotory exploration behavior (GO:0035641)4.21871674
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.20545151
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.12471922
23behavioral response to nicotine (GO:0035095)4.10997051
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.09453006
25dendritic spine morphogenesis (GO:0060997)4.07278070
26auditory behavior (GO:0031223)4.04804188
27response to histamine (GO:0034776)4.00900672
28DNA replication checkpoint (GO:0000076)3.97895606
29regulation of neuronal synaptic plasticity (GO:0048168)3.97771113
30postsynaptic membrane organization (GO:0001941)3.95515785
31regulation of synaptic vesicle transport (GO:1902803)3.94288478
32positive regulation of membrane potential (GO:0045838)3.94071623
33L-serine metabolic process (GO:0006563)3.89156137
34prepulse inhibition (GO:0060134)3.84162636
35positive regulation of synaptic transmission, GABAergic (GO:0032230)3.82757420
36regulation of protein kinase A signaling (GO:0010738)3.81183168
37nephron epithelium morphogenesis (GO:0072088)3.79831517
38nephron tubule morphogenesis (GO:0072078)3.79831517
39neuron-neuron synaptic transmission (GO:0007270)3.78346619
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.76996886
41striatum development (GO:0021756)3.74374307
42meiotic chromosome segregation (GO:0045132)3.74110032
43DNA strand renaturation (GO:0000733)3.72635656
44neurotransmitter-gated ion channel clustering (GO:0072578)3.72449898
45regulation of nuclear cell cycle DNA replication (GO:0033262)3.70673770
46synaptic transmission, glutamatergic (GO:0035249)3.70319421
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.67528281
48long-term memory (GO:0007616)3.67046555
49synaptic transmission, dopaminergic (GO:0001963)3.66932239
50short-term memory (GO:0007614)3.65799468
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.63260469
52mechanosensory behavior (GO:0007638)3.62144837
53glutamate receptor signaling pathway (GO:0007215)3.61976558
54response to auditory stimulus (GO:0010996)3.59199278
55presynaptic membrane assembly (GO:0097105)3.56469878
56heterochromatin organization (GO:0070828)3.53848918
57transmission of nerve impulse (GO:0019226)3.53686428
58regulation of excitatory postsynaptic membrane potential (GO:0060079)3.51349930
59positive regulation of synapse maturation (GO:0090129)3.49000942
60positive regulation of neurotransmitter transport (GO:0051590)3.48902613
61peptidyl-arginine omega-N-methylation (GO:0035247)3.48132665
62gamma-aminobutyric acid transport (GO:0015812)3.46052838
63neurotransmitter transport (GO:0006836)3.44384920
64positive regulation of synapse assembly (GO:0051965)3.42080163
65regulation of glutamate secretion (GO:0014048)3.41229680
66regulation of postsynaptic membrane potential (GO:0060078)3.40384042
67regulation of synapse structural plasticity (GO:0051823)3.39463919
68layer formation in cerebral cortex (GO:0021819)3.32555026
69presynaptic membrane organization (GO:0097090)3.31800706
70neuronal ion channel clustering (GO:0045161)3.29299190
71regulation of neurotransmitter levels (GO:0001505)3.27982999
72intestinal cholesterol absorption (GO:0030299)3.27671967
73positive regulation of neurotransmitter secretion (GO:0001956)3.27055891
74regulation of synaptic transmission, GABAergic (GO:0032228)3.26337579
75social behavior (GO:0035176)3.25803533
76intraspecies interaction between organisms (GO:0051703)3.25803533
77regulation of translational fidelity (GO:0006450)3.25444062
78neuron recognition (GO:0008038)3.23966194
79regulation of dopamine metabolic process (GO:0042053)3.23035902
80regulation of catecholamine metabolic process (GO:0042069)3.23035902
81serine family amino acid biosynthetic process (GO:0009070)3.21728113
82cerebellar Purkinje cell layer development (GO:0021680)3.21222971
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19544684
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.19544684
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.17200878
86regulation of synaptic transmission, glutamatergic (GO:0051966)3.16934316
87serine family amino acid catabolic process (GO:0009071)3.16794855
88membrane hyperpolarization (GO:0060081)3.15616243
89regulation of synaptic plasticity (GO:0048167)3.14992965
90behavioral response to cocaine (GO:0048148)3.14571010
91glycine metabolic process (GO:0006544)3.13172070
92adult walking behavior (GO:0007628)3.12577852
93exploration behavior (GO:0035640)3.11817950
94positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11352990
95negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09082907
96DNA strand elongation involved in DNA replication (GO:0006271)3.08862548
97negative regulation of translation, ncRNA-mediated (GO:0040033)3.07450127
98regulation of translation, ncRNA-mediated (GO:0045974)3.07450127
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.07450127
100synapse assembly (GO:0007416)3.06850246
101neuromuscular process controlling balance (GO:0050885)3.06831242
102female mating behavior (GO:0060180)3.06763256
103regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05328504
104DNA replication initiation (GO:0006270)3.00578074
105adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.99333247
106G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98960202
107G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.98619568
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.98390036
109peptidyl-arginine methylation (GO:0018216)2.97901110
110peptidyl-arginine N-methylation (GO:0035246)2.97901110
111regulation of neurotransmitter secretion (GO:0046928)2.97651463
112regulation of female receptivity (GO:0045924)2.96061814
113regulation of vesicle fusion (GO:0031338)2.95291952
114cerebellar Purkinje cell differentiation (GO:0021702)2.95131104
115learning (GO:0007612)2.94625932
116negative regulation of amino acid transport (GO:0051956)2.94428455
117serotonin metabolic process (GO:0042428)2.93173321
118regulation of respiratory gaseous exchange (GO:0043576)2.92738917
119response to amphetamine (GO:0001975)2.92381795
120translational termination (GO:0006415)2.91298384
121viral transcription (GO:0019083)2.91172648
122behavioral defense response (GO:0002209)2.90559733
123behavioral fear response (GO:0001662)2.90559733
124membrane depolarization (GO:0051899)2.89781571
125plasma lipoprotein particle assembly (GO:0034377)2.89676929
126long-term synaptic potentiation (GO:0060291)2.89542955
127DNA replication-dependent nucleosome assembly (GO:0006335)2.89300320
128DNA replication-dependent nucleosome organization (GO:0034723)2.89300320
129DNA strand elongation (GO:0022616)2.88870425
130replication fork processing (GO:0031297)2.84773129
131maturation of SSU-rRNA (GO:0030490)2.77596576
132regulation of hippo signaling (GO:0035330)2.73744969
133chromatin assembly (GO:0031497)2.72879298
134high-density lipoprotein particle remodeling (GO:0034375)2.70746554
135pre-miRNA processing (GO:0031054)2.69077597
136negative regulation of astrocyte differentiation (GO:0048712)2.68901064
137histone H3-K9 methylation (GO:0051567)2.66126605
138ribosomal small subunit assembly (GO:0000028)2.65939890
139lung epithelium development (GO:0060428)2.65305015
140very-low-density lipoprotein particle assembly (GO:0034379)2.63522536
141regulation of gene silencing (GO:0060968)2.63234532
142regulation of histone H3-K9 methylation (GO:0051570)2.63227737
143tetrahydrofolate metabolic process (GO:0046653)2.62458598
144serine family amino acid metabolic process (GO:0009069)2.62169155
145ribosomal small subunit biogenesis (GO:0042274)2.61573255
146nucleobase biosynthetic process (GO:0046112)2.60208622
147DNA topological change (GO:0006265)2.58384919
148negative regulation of telomerase activity (GO:0051974)2.57679417
149water-soluble vitamin biosynthetic process (GO:0042364)2.57446358
150regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.56844316
151regulation of non-canonical Wnt signaling pathway (GO:2000050)2.56584700
152maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.56562538
153protein carboxylation (GO:0018214)2.56118541
154peptidyl-glutamic acid carboxylation (GO:0017187)2.56118541
155DNA unwinding involved in DNA replication (GO:0006268)2.55932631
156negative regulation of telomere maintenance (GO:0032205)2.54374807
157negative regulation of histone methylation (GO:0031061)2.53486983
158positive regulation by host of viral transcription (GO:0043923)2.53256587
159renal tubule morphogenesis (GO:0061333)2.52228778
160proline metabolic process (GO:0006560)2.51053976
161regulation of stem cell maintenance (GO:2000036)2.50667032
162negative regulation of sodium ion transport (GO:0010766)2.50254190
163homocysteine metabolic process (GO:0050667)2.50014368
164protein-lipid complex remodeling (GO:0034368)2.48506144
165macromolecular complex remodeling (GO:0034367)2.48506144
166plasma lipoprotein particle remodeling (GO:0034369)2.48506144
167L-fucose catabolic process (GO:0042355)2.47321688
168fucose catabolic process (GO:0019317)2.47321688
169L-fucose metabolic process (GO:0042354)2.47321688
170chromatin remodeling at centromere (GO:0031055)2.46754486
171tRNA modification (GO:0006400)2.46295236
172cellular response to cholesterol (GO:0071397)2.45044024
173low-density lipoprotein particle remodeling (GO:0034374)2.44827482
174reciprocal DNA recombination (GO:0035825)2.44462121
175reciprocal meiotic recombination (GO:0007131)2.44462121
176kidney morphogenesis (GO:0060993)2.41271296
177translational elongation (GO:0006414)2.40503346
178cellular anion homeostasis (GO:0030002)2.38885427
179ncRNA catabolic process (GO:0034661)2.37252986
180regulation of centrosome cycle (GO:0046605)2.36874286
181cysteine metabolic process (GO:0006534)2.35881950
182telomere maintenance via semi-conservative replication (GO:0032201)2.35589118
183plasma lipoprotein particle clearance (GO:0034381)2.35346882
184basic amino acid transport (GO:0015802)2.33887204
185positive regulation of CREB transcription factor activity (GO:0032793)2.32877541
186nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.32347217
187peristalsis (GO:0030432)2.31825162
188L-alpha-amino acid transmembrane transport (GO:1902475)2.30551841
189plasma lipoprotein particle organization (GO:0071827)2.29765596
190reverse cholesterol transport (GO:0043691)2.28884455
191pseudouridine synthesis (GO:0001522)2.27960360
192mitochondrial RNA metabolic process (GO:0000959)2.27722063
193triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.27533101
194axon ensheathment in central nervous system (GO:0032291)2.26903531
195central nervous system myelination (GO:0022010)2.26903531
196translesion synthesis (GO:0019985)2.25904742
197phosphate ion homeostasis (GO:0055062)2.24906311
198trivalent inorganic anion homeostasis (GO:0072506)2.24906311
199kynurenine metabolic process (GO:0070189)2.24785486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.93735378
2E2F7_22180533_ChIP-Seq_HELA_Human6.67359983
3* RARB_27405468_Chip-Seq_BRAIN_Mouse3.36628710
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.17483731
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15468195
6GBX2_23144817_ChIP-Seq_PC3_Human2.99236309
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98407377
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85657627
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.72767918
10REST_21632747_ChIP-Seq_MESCs_Mouse2.67650825
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.64038209
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63848961
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.61942287
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.60080118
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.59160733
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57063036
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57063036
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.53913537
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52420997
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.46742871
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.46676692
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.46627821
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.42274775
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40799129
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.38994668
26DROSHA_22980978_ChIP-Seq_HELA_Human2.38863758
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34881172
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33981716
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31243049
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.24333367
31TP63_19390658_ChIP-ChIP_HaCaT_Human2.23458472
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22545214
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21200135
34MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18501080
35XRN2_22483619_ChIP-Seq_HELA_Human2.12556526
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07121156
37EED_16625203_ChIP-ChIP_MESCs_Mouse2.04319177
38TAF15_26573619_Chip-Seq_HEK293_Human2.00874321
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.93298306
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91782317
41* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88704894
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.84520337
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.84028822
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.83426480
45* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82402043
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80007280
47MYC_18940864_ChIP-ChIP_HL60_Human1.76390924
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75216638
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.74841936
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.74772443
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74530152
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.73423545
53TTF2_22483619_ChIP-Seq_HELA_Human1.70413375
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.69350976
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68446244
56AR_21572438_ChIP-Seq_LNCaP_Human1.65284227
57IRF1_19129219_ChIP-ChIP_H3396_Human1.61707144
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.57739293
59* RING1B_27294783_Chip-Seq_ESCs_Mouse1.53995010
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.53531536
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53365372
62MYC_22102868_ChIP-Seq_BL_Human1.52157601
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51797691
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51057716
65GABP_19822575_ChIP-Seq_HepG2_Human1.49080099
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46887194
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46396714
68FOXP3_21729870_ChIP-Seq_TREG_Human1.46345715
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44822044
70CTCF_27219007_Chip-Seq_Bcells_Human1.44639703
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.38349567
72* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31843944
73KDM5A_27292631_Chip-Seq_BREAST_Human1.30804242
74PHF8_20622854_ChIP-Seq_HELA_Human1.29782495
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29176755
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29137658
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26893244
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26789824
79EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23939176
80E2F1_20622854_ChIP-Seq_HELA_Human1.23656243
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21809902
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21461951
83CIITA_25753668_ChIP-Seq_RAJI_Human1.21449880
84ERA_21632823_ChIP-Seq_H3396_Human1.20882383
85GABP_17652178_ChIP-ChIP_JURKAT_Human1.20571844
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.19986643
87LXR_22292898_ChIP-Seq_THP-1_Human1.19432778
88ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.18797605
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17787305
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16594315
91CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15890699
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15180676
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14066478
94KDM2B_26808549_Chip-Seq_K562_Human1.13494616
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.12203298
96* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12098485
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11494772
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10379824
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08084607
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08084607
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08084607
102ZNF274_21170338_ChIP-Seq_K562_Hela1.07884482
103NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07699554
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06605106
105RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06184276
106MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05490429
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05062478
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04178671
109KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03789725
110VDR_22108803_ChIP-Seq_LS180_Human1.03081140
111YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01691252
112E2F1_17053090_ChIP-ChIP_MCF-7_Human1.01636302
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00499847
114VDR_23849224_ChIP-Seq_CD4+_Human1.00480299
115RAC3_21632823_ChIP-Seq_H3396_Human1.00353370
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00194019
117POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99805292
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.99285884
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99114850
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98693755
121* RNF2_27304074_Chip-Seq_NSC_Mouse0.98504179
122* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98363809
123RARA_24833708_ChIP-Seq_LIVER_Mouse0.97827241
124SA1_27219007_Chip-Seq_ERYTHROID_Human0.96510044
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95416609
126KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95084298
127MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94532154
128OCT4_19829295_ChIP-Seq_ESCs_Human0.93935669
129KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93821904
130* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.93705594
131P53_21459846_ChIP-Seq_SAOS-2_Human0.93566054
132SRF_21415370_ChIP-Seq_HL-1_Mouse0.92846741
133POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92602898
134ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92121012
135TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91618941
136EWS_26573619_Chip-Seq_HEK293_Human0.91499799
137GATA1_26923725_Chip-Seq_HPCs_Mouse0.91459165
138RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90717072
139GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90284094
140OCT4_20526341_ChIP-Seq_ESCs_Human0.89956588
141MYC_18555785_ChIP-Seq_MESCs_Mouse0.89191430
142SMC4_20622854_ChIP-Seq_HELA_Human0.88380261
143* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.88006213
144YY1_22570637_ChIP-Seq_MALME-3M_Human0.87123268
145TET1_21490601_ChIP-Seq_MESCs_Mouse0.86898407
146YY1_21170310_ChIP-Seq_MESCs_Mouse0.86265612
147SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.86088466
148KDM2B_26808549_Chip-Seq_JURKAT_Human0.85571605
149RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84345088
150SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83311814
151ETS1_20019798_ChIP-Seq_JURKAT_Human0.81930202
152OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81522852
153ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81473131
154SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79325551
155CBX2_27304074_Chip-Seq_ESCs_Mouse0.79286513
156TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79152886
157P68_20966046_ChIP-Seq_HELA_Human0.78568525
158CREB1_26743006_Chip-Seq_LNCaP_Human0.77466315
159KLF4_19829295_ChIP-Seq_ESCs_Human0.77130169
160TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76197931
161MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75286980
162EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.75067019
163TET1_21451524_ChIP-Seq_MESCs_Mouse0.74417181
164* FOXP1_21924763_ChIP-Seq_HESCs_Human0.74200320
165AR_19668381_ChIP-Seq_PC3_Human0.73531059
166KDM2B_26808549_Chip-Seq_DND41_Human0.73338949
167SOX2_16153702_ChIP-ChIP_HESCs_Human0.73047710
168POU5F1_16518401_ChIP-PET_MESCs_Mouse0.72127051
169KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.72048680
170CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71811596

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.17180027
2MP0004859_abnormal_synaptic_plasticity4.83195002
3MP0002822_catalepsy3.82797993
4MP0003635_abnormal_synaptic_transmissio3.64818082
5MP0009745_abnormal_behavioral_response3.31961747
6MP0002064_seizures3.01630577
7MP0009046_muscle_twitch2.89150714
8MP0004270_analgesia2.86596794
9MP0002063_abnormal_learning/memory/cond2.82503151
10MP0000566_synostosis2.69397438
11MP0001968_abnormal_touch/_nociception2.66170677
12MP0005423_abnormal_somatic_nervous2.64613858
13MP0003890_abnormal_embryonic-extraembry2.62140476
14MP0003693_abnormal_embryo_hatching2.59308649
15MP0002572_abnormal_emotion/affect_behav2.52860639
16MP0001188_hyperpigmentation2.36613947
17MP0003111_abnormal_nucleus_morphology2.35030782
18MP0002272_abnormal_nervous_system2.33174450
19MP0010094_abnormal_chromosome_stability2.28916559
20MP0003195_calcinosis2.20158560
21MP0001486_abnormal_startle_reflex2.18562137
22MP0003122_maternal_imprinting2.17398396
23MP0002734_abnormal_mechanical_nocicepti2.16489861
24MP0001501_abnormal_sleep_pattern2.14219844
25MP0001529_abnormal_vocalization2.11461192
26MP0003567_abnormal_fetal_cardiomyocyte2.04633285
27MP0002938_white_spotting2.01898830
28MP0005409_darkened_coat_color2.00639052
29MP0006276_abnormal_autonomic_nervous1.99985528
30MP0004142_abnormal_muscle_tone1.98237958
31MP0002557_abnormal_social/conspecific_i1.89366417
32MP0005499_abnormal_olfactory_system1.86881016
33MP0005394_taste/olfaction_phenotype1.86881016
34MP0008058_abnormal_DNA_repair1.84786475
35MP0002796_impaired_skin_barrier1.84492683
36MP0001440_abnormal_grooming_behavior1.82631503
37MP0000778_abnormal_nervous_system1.77434627
38MP0005645_abnormal_hypothalamus_physiol1.75843663
39MP0002067_abnormal_sensory_capabilities1.74533101
40MP0001905_abnormal_dopamine_level1.74304195
41MP0002254_reproductive_system_inflammat1.72261159
42MP0003878_abnormal_ear_physiology1.72086779
43MP0005377_hearing/vestibular/ear_phenot1.72086779
44MP0002736_abnormal_nociception_after1.71179426
45MP0004133_heterotaxia1.68221703
46MP0001970_abnormal_pain_threshold1.62973602
47MP0003718_maternal_effect1.61677715
48MP0001293_anophthalmia1.61011618
49MP0002184_abnormal_innervation1.58774046
50MP0002733_abnormal_thermal_nociception1.56518894
51MP0003941_abnormal_skin_development1.55438001
52MP0002909_abnormal_adrenal_gland1.54689373
53MP0008569_lethality_at_weaning1.54676672
54MP0005646_abnormal_pituitary_gland1.54164285
55MP0006292_abnormal_olfactory_placode1.52635412
56MP0003329_amyloid_beta_deposits1.51281068
57MP0002089_abnormal_postnatal_growth/wei1.51273299
58MP0008057_abnormal_DNA_replication1.47440584
59MP0004957_abnormal_blastocyst_morpholog1.47215405
60MP0003937_abnormal_limbs/digits/tail_de1.46721151
61MP0001986_abnormal_taste_sensitivity1.46363230
62MP0005386_behavior/neurological_phenoty1.45799552
63MP0004924_abnormal_behavior1.45799552
64MP0004811_abnormal_neuron_physiology1.41960018
65MP0003879_abnormal_hair_cell1.41352858
66MP0003283_abnormal_digestive_organ1.40635013
67MP0010329_abnormal_lipoprotein_level1.34349299
68MP0002638_abnormal_pupillary_reflex1.31201475
69MP0000631_abnormal_neuroendocrine_gland1.31010341
70MP0004147_increased_porphyrin_level1.30651042
71MP0002882_abnormal_neuron_morphology1.28426586
72MP0001286_abnormal_eye_development1.26978895
73MP0004742_abnormal_vestibular_system1.26799914
74MP0002066_abnormal_motor_capabilities/c1.25547018
75MP0008875_abnormal_xenobiotic_pharmacok1.25173489
76MP0002139_abnormal_hepatobiliary_system1.25053625
77MP0010030_abnormal_orbit_morphology1.24693390
78MP0008995_early_reproductive_senescence1.24107899
79MP0005365_abnormal_bile_salt1.23573398
80MP0005360_urolithiasis1.23477509
81MP0003787_abnormal_imprinting1.22562807
82MP0009672_abnormal_birth_weight1.22178499
83MP0008932_abnormal_embryonic_tissue1.22007012
84MP0008789_abnormal_olfactory_epithelium1.20941820
85MP0003077_abnormal_cell_cycle1.20719087
86MP0002653_abnormal_ependyma_morphology1.18525726
87MP0000955_abnormal_spinal_cord1.17483115
88MP0001984_abnormal_olfaction1.16996076
89MP0003315_abnormal_perineum_morphology1.12897658
90MP0002210_abnormal_sex_determination1.12022628
91MP0008872_abnormal_physiological_respon1.11563539
92MP0002160_abnormal_reproductive_system1.10886693
93MP0002152_abnormal_brain_morphology1.10139635
94MP0001502_abnormal_circadian_rhythm1.08466999
95MP0008877_abnormal_DNA_methylation1.03581655
96MP0009379_abnormal_foot_pigmentation1.03493109
97MP0003942_abnormal_urinary_system1.02410306
98MP0010234_abnormal_vibrissa_follicle1.01992457
99MP0003698_abnormal_male_reproductive1.01523964
100MP0002735_abnormal_chemical_nociception1.00954271
101MP0005380_embryogenesis_phenotype0.98948608
102MP0001672_abnormal_embryogenesis/_devel0.98948608
103MP0001929_abnormal_gametogenesis0.98778958
104MP0005501_abnormal_skin_physiology0.97657132
105MP0003123_paternal_imprinting0.97230372
106MP0002111_abnormal_tail_morphology0.94160561
107MP0002069_abnormal_eating/drinking_beha0.93369029
108MP0004381_abnormal_hair_follicle0.92421194
109MP0001145_abnormal_male_reproductive0.90749491
110MP0002697_abnormal_eye_size0.90384709
111MP0004885_abnormal_endolymph0.88623908
112MP0006072_abnormal_retinal_apoptosis0.88518891
113MP0001697_abnormal_embryo_size0.87662456
114MP0005332_abnormal_amino_acid0.87380578
115MP0004197_abnormal_fetal_growth/weight/0.87097515
116MP0002085_abnormal_embryonic_tissue0.86563050
117MP0002084_abnormal_developmental_patter0.86415076
118MP0003984_embryonic_growth_retardation0.86055980
119MP0003938_abnormal_ear_development0.84438582
120MP0003121_genomic_imprinting0.84135699
121MP0002088_abnormal_embryonic_growth/wei0.84090065
122MP0000653_abnormal_sex_gland0.83993365
123MP0005220_abnormal_exocrine_pancreas0.82621134
124MP0005076_abnormal_cell_differentiation0.82451544
125MP0005195_abnormal_posterior_eye0.81991336
126MP0004043_abnormal_pH_regulation0.81777761
127MP0008961_abnormal_basal_metabolism0.81259285
128MP0001485_abnormal_pinna_reflex0.81241497
129MP0002752_abnormal_somatic_nervous0.80709732
130MP0004145_abnormal_muscle_electrophysio0.80698756
131MP0002751_abnormal_autonomic_nervous0.80239061
132MP0005174_abnormal_tail_pigmentation0.79767503
133MP0003633_abnormal_nervous_system0.79707385
134MP0005410_abnormal_fertilization0.79614634
135MP0003861_abnormal_nervous_system0.79430261
136MP0002229_neurodegeneration0.78368666
137MP0003943_abnormal_hepatobiliary_system0.78220774
138MP0001324_abnormal_eye_pigmentation0.77976277
139MP0005389_reproductive_system_phenotype0.77794796
140MP0005084_abnormal_gallbladder_morpholo0.77014884
141MP0008007_abnormal_cellular_replicative0.76457067
142MP0002161_abnormal_fertility/fecundity0.74334129
143MP0008874_decreased_physiological_sensi0.73235258
144MP0001730_embryonic_growth_arrest0.72079713
145MP0000678_abnormal_parathyroid_gland0.70797599
146MP0010771_integument_phenotype0.70646247
147MP0003136_yellow_coat_color0.70082789
148MP0001963_abnormal_hearing_physiology0.68179472
149MP0005551_abnormal_eye_electrophysiolog0.66910022
150MP0000751_myopathy0.66298247
151MP0000579_abnormal_nail_morphology0.66055242
152MP0004858_abnormal_nervous_system0.65330880
153MP0010769_abnormal_survival0.64583243
154MP0003631_nervous_system_phenotype0.64246744
155MP0010768_mortality/aging0.64127423
156MP0001177_atelectasis0.63357939
157MP0010770_preweaning_lethality0.62854861
158MP0002082_postnatal_lethality0.62854861
159MP0002177_abnormal_outer_ear0.62491435
160MP0001299_abnormal_eye_distance/0.60228219
161MP0000049_abnormal_middle_ear0.60064509
162MP0003119_abnormal_digestive_system0.59788087
163MP0002234_abnormal_pharynx_morphology0.59584088
164MP0002102_abnormal_ear_morphology0.59050063

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.96377949
2Focal seizures (HP:0007359)5.66893485
3Myokymia (HP:0002411)5.22368885
4Visual hallucinations (HP:0002367)4.84242829
5Absence seizures (HP:0002121)4.42326322
6Dialeptic seizures (HP:0011146)4.12480170
7Atonic seizures (HP:0010819)4.06177493
8Epileptic encephalopathy (HP:0200134)4.03960816
9Birth length less than 3rd percentile (HP:0003561)3.74944536
10Broad-based gait (HP:0002136)3.68168569
11Febrile seizures (HP:0002373)3.65170357
12Concave nail (HP:0001598)3.50973059
13Generalized tonic-clonic seizures (HP:0002069)3.26098783
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20203680
15Patellar aplasia (HP:0006443)3.19913360
16Abnormal number of erythroid precursors (HP:0012131)3.12347523
17Abnormality of the labia minora (HP:0012880)3.08704273
18Poor suck (HP:0002033)3.08411826
19Abnormality of cells of the erythroid lineage (HP:0012130)3.04948466
20Bilateral microphthalmos (HP:0007633)3.02976781
21Hyperthyroidism (HP:0000836)2.94972904
22Aplasia/Hypoplasia of the patella (HP:0006498)2.92195452
23Chromsome breakage (HP:0040012)2.84374529
24Polyphagia (HP:0002591)2.83722568
25Vaginal fistula (HP:0004320)2.78950354
26Pendular nystagmus (HP:0012043)2.78218978
27Prolonged partial thromboplastin time (HP:0003645)2.76143128
28Sleep apnea (HP:0010535)2.71611110
29Poor eye contact (HP:0000817)2.71533958
30Ankle clonus (HP:0011448)2.70863310
31Impaired vibration sensation in the lower limbs (HP:0002166)2.66248671
32Meckel diverticulum (HP:0002245)2.65684910
33Abnormal eating behavior (HP:0100738)2.64892440
34Abnormal social behavior (HP:0012433)2.60334600
35Impaired social interactions (HP:0000735)2.60334600
36Abnormality of the ileum (HP:0001549)2.60234034
37Intestinal fistula (HP:0100819)2.55504613
38Rectal fistula (HP:0100590)2.54869850
39Rectovaginal fistula (HP:0000143)2.54869850
40Congenital stationary night blindness (HP:0007642)2.53910281
41Depression (HP:0000716)2.47418034
42Abnormality of DNA repair (HP:0003254)2.47195915
43Deep venous thrombosis (HP:0002625)2.43909517
44Rib fusion (HP:0000902)2.43234797
45Hyperglycinuria (HP:0003108)2.41809880
46Limb dystonia (HP:0002451)2.40895048
47Hyperglycinemia (HP:0002154)2.38595133
48Hypoplasia of the pons (HP:0012110)2.37383968
49Homocystinuria (HP:0002156)2.35077959
50Abnormality of homocysteine metabolism (HP:0010919)2.35077959
51Progressive cerebellar ataxia (HP:0002073)2.33478866
52Ectopic kidney (HP:0000086)2.31013174
53Failure to thrive in infancy (HP:0001531)2.30494508
54Anxiety (HP:0000739)2.29836548
55Generalized hypotonia (HP:0001290)2.29072723
56Anophthalmia (HP:0000528)2.28227237
57Bowel incontinence (HP:0002607)2.27933725
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27408797
59Abnormality of alanine metabolism (HP:0010916)2.27408797
60Hyperalaninemia (HP:0003348)2.27408797
61Type II lissencephaly (HP:0007260)2.25996022
62Abnormality of the pons (HP:0007361)2.23840697
63Absent radius (HP:0003974)2.23410605
64Impulsivity (HP:0100710)2.22681023
65Lissencephaly (HP:0001339)2.22475357
66Broad alveolar ridges (HP:0000187)2.22237680
67Irregular epiphyses (HP:0010582)2.21616691
68Hepatoblastoma (HP:0002884)2.21465309
69Abnormal large intestine physiology (HP:0012700)2.20273942
70Duplicated collecting system (HP:0000081)2.20107322
71Supranuclear gaze palsy (HP:0000605)2.18409695
72Aplasia involving forearm bones (HP:0009822)2.17204110
73Absent forearm bone (HP:0003953)2.17204110
74Hyperventilation (HP:0002883)2.17164165
75Truncal ataxia (HP:0002078)2.16851229
76Truncus arteriosus (HP:0001660)2.16759629
77Enlarged kidneys (HP:0000105)2.15298915
78Absent thumb (HP:0009777)2.14482814
79Pancreatic islet-cell hyperplasia (HP:0004510)2.12724369
80Pointed chin (HP:0000307)2.10342958
81Spastic gait (HP:0002064)2.09821977
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.09526379
83Abnormality of cochlea (HP:0000375)2.07130204
84Fragile nails (HP:0001808)2.06884173
85Abnormality of glycine metabolism (HP:0010895)2.06164225
86Abnormality of serine family amino acid metabolism (HP:0010894)2.06164225
87Cerebellar dysplasia (HP:0007033)2.04905385
88Progressive inability to walk (HP:0002505)2.03479829
89Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03206289
90Gaze-evoked nystagmus (HP:0000640)2.01896780
91Horseshoe kidney (HP:0000085)2.01765178
92Pancreatic cysts (HP:0001737)2.01340468
93Inability to walk (HP:0002540)2.00495063
94Status epilepticus (HP:0002133)1.99025212
95Diastasis recti (HP:0001540)1.97177028
96Protruding tongue (HP:0010808)1.96879827
97Urinary urgency (HP:0000012)1.96108696
98Impaired smooth pursuit (HP:0007772)1.95853592
99Colon cancer (HP:0003003)1.95535564
100Shoulder girdle muscle weakness (HP:0003547)1.95489183
101Partial agenesis of the corpus callosum (HP:0001338)1.94539943
102Abnormality of the renal collecting system (HP:0004742)1.93901681
103Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.92509672
104Esotropia (HP:0000565)1.92077175
105Generalized myoclonic seizures (HP:0002123)1.91531603
106Abnormal hair whorl (HP:0010721)1.91453996
107Urinary bladder sphincter dysfunction (HP:0002839)1.90878100
108Abnormality of midbrain morphology (HP:0002418)1.90754429
109Molar tooth sign on MRI (HP:0002419)1.90754429
11011 pairs of ribs (HP:0000878)1.90465592
111Deep palmar crease (HP:0006191)1.90250197
112Dysmetria (HP:0001310)1.88764943
113Amblyopia (HP:0000646)1.88452824
114Trigonocephaly (HP:0000243)1.88405011
115Cerebral hypomyelination (HP:0006808)1.87974326
116Pancreatic fibrosis (HP:0100732)1.87595976
117Attenuation of retinal blood vessels (HP:0007843)1.87441050
118Obstructive sleep apnea (HP:0002870)1.86909574
119Sparse scalp hair (HP:0002209)1.86372950
120Lower limb amyotrophy (HP:0007210)1.86069353
121Triphalangeal thumb (HP:0001199)1.85087968
122Abnormality of the carotid arteries (HP:0005344)1.84688064
123Unsteady gait (HP:0002317)1.83431895
124Annular pancreas (HP:0001734)1.82986371
125Absent epiphyses (HP:0010577)1.82700288
126Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82700288
127Megalencephaly (HP:0001355)1.82035613
128Nephroblastoma (Wilms tumor) (HP:0002667)1.81850950
129Squamous cell carcinoma (HP:0002860)1.81524903
130Epileptiform EEG discharges (HP:0011182)1.79660888
131Aplasia/Hypoplasia of the sternum (HP:0006714)1.79110259
132Short thumb (HP:0009778)1.78817696
133Psychosis (HP:0000709)1.78311978
134Scanning speech (HP:0002168)1.77942786
135Short chin (HP:0000331)1.77666134
136Neuronal loss in central nervous system (HP:0002529)1.77621280
137Iris hypopigmentation (HP:0007730)1.77179532
138Increased IgE level (HP:0003212)1.77160276
139Dysdiadochokinesis (HP:0002075)1.76977283
140Abnormality of the nasal septum (HP:0000419)1.75985597
141Hemiparesis (HP:0001269)1.75611303
142Morphological abnormality of the inner ear (HP:0011390)1.75539731
143Bile duct proliferation (HP:0001408)1.74298414
144Abnormal biliary tract physiology (HP:0012439)1.74298414
145Hypobetalipoproteinemia (HP:0003563)1.74010595
146Nephronophthisis (HP:0000090)1.73909226
147Papilledema (HP:0001085)1.73711817
148Dandy-Walker malformation (HP:0001305)1.72786162
149Sloping forehead (HP:0000340)1.72671366
150Stereotypic behavior (HP:0000733)1.72570081
151Delusions (HP:0000746)1.72286768
152Specific learning disability (HP:0001328)1.71648447
153Large eyes (HP:0001090)1.71638314
154Sclerocornea (HP:0000647)1.71222503
155Drooling (HP:0002307)1.71012060
156Excessive salivation (HP:0003781)1.71012060
157Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70992934
158Breast hypoplasia (HP:0003187)1.70782099
159True hermaphroditism (HP:0010459)1.70560076
160Abnormality of the pubic bones (HP:0003172)1.70397295
161Capillary hemangiomas (HP:0005306)1.70249269
162EEG with generalized epileptiform discharges (HP:0011198)1.70208230
163Reticulocytopenia (HP:0001896)1.70140384
164Abnormality of the preputium (HP:0100587)1.69886079
165Abnormality of the vitreous humor (HP:0004327)1.69841893
166Pallor (HP:0000980)1.69784705
167Supernumerary bones of the axial skeleton (HP:0009144)1.69483795
168Achilles tendon contracture (HP:0001771)1.69201446
169Genetic anticipation (HP:0003743)1.69076418
170Distal lower limb amyotrophy (HP:0008944)1.68448457
171Ventricular fibrillation (HP:0001663)1.67463803
172Macrocytic anemia (HP:0001972)1.66997465
173Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66391887
174Poikiloderma (HP:0001029)1.66217400
175Upper limb muscle weakness (HP:0003484)1.65655049
176Oral leukoplakia (HP:0002745)1.64430959
177Embryonal renal neoplasm (HP:0011794)1.63894108
178Acute lymphatic leukemia (HP:0006721)1.63552356
179Scrotal hypoplasia (HP:0000046)1.63380686
180Torticollis (HP:0000473)1.62985010
181Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62352386
182Atelectasis (HP:0100750)1.62057684
183Septo-optic dysplasia (HP:0100842)1.60800939
184Hypotrichosis (HP:0001006)1.60414120
185Abolished electroretinogram (ERG) (HP:0000550)1.60328872
186Supernumerary spleens (HP:0009799)1.59858513
187Resting tremor (HP:0002322)1.58735065
188Congenital ichthyosiform erythroderma (HP:0007431)1.58464436
189Woolly hair (HP:0002224)1.57774834
190Hemiplegia (HP:0002301)1.57548993
191Lip pit (HP:0100267)1.57063586
192Focal dystonia (HP:0004373)1.56796431
193Stenosis of the external auditory canal (HP:0000402)1.56590846
194Fetal akinesia sequence (HP:0001989)1.53429645
195Cortical visual impairment (HP:0100704)1.53165728
196Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.51524125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.25329388
2TLK14.22918129
3NTRK33.69614137
4MAP3K93.64773771
5CASK3.38304844
6CDC73.36609181
7EEF2K3.16609402
8ZAK3.09629802
9CDK192.72437079
10MAP3K42.71930996
11PNCK2.54009036
12NTRK22.48868182
13MAP3K122.43577318
14DAPK22.36698664
15MAP2K72.27258171
16NEK22.16799027
17FES2.12858454
18MINK11.99286956
19BMPR1B1.96317030
20FGFR41.95193486
21MAP2K41.90770016
22DYRK21.86986846
23SIK21.86746139
24TNIK1.79641543
25INSRR1.78485832
26MARK11.78330015
27MKNK11.78287596
28CHEK21.68808760
29FRK1.62797927
30NME11.59621610
31WNK11.56063997
32TTK1.55697086
33NUAK11.54352307
34CDK121.52355216
35UHMK11.50196478
36DAPK11.46130855
37ATR1.44995969
38TYRO31.42705189
39CDK51.39025030
40RIPK41.38914257
41CAMK1D1.38798527
42ADRBK21.37332143
43DAPK31.29826710
44PAK61.29800179
45MAP3K101.27203657
46ACVR1B1.26364822
47WEE11.24478728
48PLK41.20886065
49VRK21.20390033
50VRK11.17403626
51GRK11.16400324
52MARK21.12755914
53TAOK11.12251721
54TSSK61.10583312
55BCKDK1.10362222
56BUB11.10091841
57ARAF1.09705445
58NTRK11.05256201
59CDK41.04687771
60MAPK151.04640746
61TAF11.04245842
62SMG11.04199129
63PASK1.04197455
64MAP3K111.03146823
65IRAK21.01267928
66STK381.00969077
67TNK20.99397877
68CAMK1G0.98199062
69FER0.97542757
70WNK30.96952442
71PLK10.96650535
72CDK140.94998205
73AKT30.94654978
74CDK180.94404256
75STK110.93787028
76CDK150.93772053
77PLK30.92704006
78PRKCG0.91538487
79FLT30.89840606
80CDK11A0.89770389
81TESK20.86849139
82BRAF0.86180871
83CDK70.84073300
84ATM0.83022729
85KSR20.81811036
86ALK0.81658509
87CHEK10.81509016
88CAMK10.81418263
89OXSR10.80861802
90KSR10.78831962
91PRPF4B0.78576823
92CAMK2A0.77823240
93RPS6KB20.77490237
94SIK30.76674865
95CDK10.75475517
96CDK20.74237556
97BRSK20.74091004
98LATS20.74069365
99PRKAA10.72703713
100FGFR30.72301182
101TRIB30.72108083
102CSNK1E0.71666817
103MAP3K130.68533886
104CAMK2B0.67851350
105SRPK10.64100172
106DYRK1A0.64005746
107PRKD20.63797495
108PRKAA20.63424332
109TGFBR10.61828023
110CSNK1G20.59636344
111GRK50.59168114
112CAMKK10.58310855
113PRKCI0.58274315
114SGK2230.57987922
115SGK4940.57987922
116MAPK100.57142438
117MAPK130.57074960
118RPS6KA60.55954222
119RPS6KA50.55897597
120MAPK110.55588946
121BRD40.55338556
122DYRK30.54832551
123BMX0.52303064
124FGFR10.51609220
125GSK3B0.51367663
126SGK10.51017162
127BCR0.50819090
128GRK60.50770404
129ERBB20.50592206
130PRKDC0.50319740
131FGR0.48749885
132ROCK20.48673426
133AKT10.48054444
134STK30.46877281
135ADRBK10.46828965
136MAP2K20.46772628
137AURKA0.46446421
138MAPKAPK50.46223346
139PRKD30.45688687
140RPS6KA10.43801479
141FYN0.42978633
142CDK30.42830202
143AURKB0.42829864
144PIM10.42216092
145MAPK140.42170127
146MTOR0.41119082
147RPS6KA30.41103054
148MATK0.41098928
149MAP3K20.40679629
150CSNK2A10.40501126
151MAP3K10.40451681
152FGFR20.39674290
153MAP3K70.39246069
154HIPK20.37947437
155CSNK2A20.37862309
156MAP4K20.37063827
157SCYL20.36855032
158CSNK1G30.34534403
159WNK40.33359253
160PRKCH0.32622368
161MKNK20.32550430
162PKN10.32328408
163MAP2K60.31575059
164CSNK1A10.30359118
165CAMK2G0.30137509
166MAPK90.29679066
167PRKCZ0.27280384
168ICK0.27123421
169CSNK1D0.26881288
170PHKG10.26822210
171PHKG20.26822210

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.25450967
2Synaptic vesicle cycle_Homo sapiens_hsa047213.79891644
3One carbon pool by folate_Homo sapiens_hsa006703.22417644
4DNA replication_Homo sapiens_hsa030302.77871817
5Selenocompound metabolism_Homo sapiens_hsa004502.71472581
6Olfactory transduction_Homo sapiens_hsa047402.69338592
7GABAergic synapse_Homo sapiens_hsa047272.68475195
8Morphine addiction_Homo sapiens_hsa050322.64772795
9Amphetamine addiction_Homo sapiens_hsa050312.62757316
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56509469
11Cocaine addiction_Homo sapiens_hsa050302.43080350
12Homologous recombination_Homo sapiens_hsa034402.35228245
13Steroid biosynthesis_Homo sapiens_hsa001002.34462259
14Long-term potentiation_Homo sapiens_hsa047202.32728424
15Circadian entrainment_Homo sapiens_hsa047132.28423466
16Fanconi anemia pathway_Homo sapiens_hsa034602.25545965
17Glutamatergic synapse_Homo sapiens_hsa047242.22959756
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.21144426
19Dopaminergic synapse_Homo sapiens_hsa047282.20964621
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13549677
21Collecting duct acid secretion_Homo sapiens_hsa049662.07298534
22Maturity onset diabetes of the young_Homo sapiens_hsa049502.05565859
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96102023
24Ribosome_Homo sapiens_hsa030101.94356450
25Base excision repair_Homo sapiens_hsa034101.93908781
26Mismatch repair_Homo sapiens_hsa034301.89748435
27Nitrogen metabolism_Homo sapiens_hsa009101.89522530
28Fat digestion and absorption_Homo sapiens_hsa049751.87063418
29Salivary secretion_Homo sapiens_hsa049701.79825935
30Serotonergic synapse_Homo sapiens_hsa047261.79451761
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76683304
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.71671168
33Taste transduction_Homo sapiens_hsa047421.71210024
34Vitamin digestion and absorption_Homo sapiens_hsa049771.71190716
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67455767
36Lysine degradation_Homo sapiens_hsa003101.66701538
37Cholinergic synapse_Homo sapiens_hsa047251.61921225
38Insulin secretion_Homo sapiens_hsa049111.61430126
39Phototransduction_Homo sapiens_hsa047441.59177533
40Long-term depression_Homo sapiens_hsa047301.55223718
41Renin secretion_Homo sapiens_hsa049241.54616989
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53842906
43Gastric acid secretion_Homo sapiens_hsa049711.52931795
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51451259
45Calcium signaling pathway_Homo sapiens_hsa040201.45665762
46Linoleic acid metabolism_Homo sapiens_hsa005911.43915549
47Oxidative phosphorylation_Homo sapiens_hsa001901.41902097
48Oxytocin signaling pathway_Homo sapiens_hsa049211.40513004
49Butanoate metabolism_Homo sapiens_hsa006501.40452567
50GnRH signaling pathway_Homo sapiens_hsa049121.38570963
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37079086
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34136192
53Nucleotide excision repair_Homo sapiens_hsa034201.33575800
54Gap junction_Homo sapiens_hsa045401.32907205
55Ether lipid metabolism_Homo sapiens_hsa005651.32397809
56Melanogenesis_Homo sapiens_hsa049161.31793521
57RNA degradation_Homo sapiens_hsa030181.31097544
58Basal transcription factors_Homo sapiens_hsa030221.28241277
59Parkinsons disease_Homo sapiens_hsa050121.26354038
60Cyanoamino acid metabolism_Homo sapiens_hsa004601.25089401
61Vibrio cholerae infection_Homo sapiens_hsa051101.24704119
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24501037
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.23271464
64Sulfur relay system_Homo sapiens_hsa041221.19405777
65Cardiac muscle contraction_Homo sapiens_hsa042601.19180956
66Biosynthesis of amino acids_Homo sapiens_hsa012301.18359762
67Fatty acid biosynthesis_Homo sapiens_hsa000611.16362665
68Axon guidance_Homo sapiens_hsa043601.16282487
69Fatty acid metabolism_Homo sapiens_hsa012121.15369009
70Alcoholism_Homo sapiens_hsa050341.14629590
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14241348
72Non-homologous end-joining_Homo sapiens_hsa034501.12158575
73Pyrimidine metabolism_Homo sapiens_hsa002401.11787447
74Cell cycle_Homo sapiens_hsa041101.11757106
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10971343
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10670162
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08578472
78Pyruvate metabolism_Homo sapiens_hsa006201.04539878
79Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00520075
80cAMP signaling pathway_Homo sapiens_hsa040240.99947598
81Estrogen signaling pathway_Homo sapiens_hsa049150.99507758
82Alzheimers disease_Homo sapiens_hsa050100.97594997
83Oocyte meiosis_Homo sapiens_hsa041140.97270915
84RNA polymerase_Homo sapiens_hsa030200.92695248
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91294944
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90673644
87ErbB signaling pathway_Homo sapiens_hsa040120.89952398
88ABC transporters_Homo sapiens_hsa020100.89547666
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89003155
90Propanoate metabolism_Homo sapiens_hsa006400.87637671
91Purine metabolism_Homo sapiens_hsa002300.86254725
92Glycerolipid metabolism_Homo sapiens_hsa005610.83673477
93MAPK signaling pathway_Homo sapiens_hsa040100.83250435
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82888615
95Glioma_Homo sapiens_hsa052140.82380196
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82222978
97Arginine and proline metabolism_Homo sapiens_hsa003300.80535961
98Wnt signaling pathway_Homo sapiens_hsa043100.80346495
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80104921
100Complement and coagulation cascades_Homo sapiens_hsa046100.79523085
101Huntingtons disease_Homo sapiens_hsa050160.77780833
102Arginine biosynthesis_Homo sapiens_hsa002200.76359415
103Tryptophan metabolism_Homo sapiens_hsa003800.76216388
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75463837
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72379686
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71118379
107Basal cell carcinoma_Homo sapiens_hsa052170.70880470
108Spliceosome_Homo sapiens_hsa030400.70812866
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.68505359
110Peroxisome_Homo sapiens_hsa041460.67935027
111Metabolic pathways_Homo sapiens_hsa011000.67918552
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66069135
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.65585539
114Type II diabetes mellitus_Homo sapiens_hsa049300.61258460
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60755062
116Histidine metabolism_Homo sapiens_hsa003400.59773314
117Fatty acid degradation_Homo sapiens_hsa000710.55748743
118mRNA surveillance pathway_Homo sapiens_hsa030150.55152950
119Vitamin B6 metabolism_Homo sapiens_hsa007500.54831122
120N-Glycan biosynthesis_Homo sapiens_hsa005100.54468568
121Choline metabolism in cancer_Homo sapiens_hsa052310.54341851
122Rap1 signaling pathway_Homo sapiens_hsa040150.52782834
123Type I diabetes mellitus_Homo sapiens_hsa049400.52530896
124Ras signaling pathway_Homo sapiens_hsa040140.52510984
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.51473243
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49678188
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49070441
128Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49005308
129Hedgehog signaling pathway_Homo sapiens_hsa043400.48425921
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47960043
131Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46946711
132Carbon metabolism_Homo sapiens_hsa012000.46618325
133Inositol phosphate metabolism_Homo sapiens_hsa005620.45825500
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45649533
135Systemic lupus erythematosus_Homo sapiens_hsa053220.45405428
136Fructose and mannose metabolism_Homo sapiens_hsa000510.45337178
137VEGF signaling pathway_Homo sapiens_hsa043700.44958102
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44280208
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42454484
140Circadian rhythm_Homo sapiens_hsa047100.39796240
141T cell receptor signaling pathway_Homo sapiens_hsa046600.38362367
142Hippo signaling pathway_Homo sapiens_hsa043900.37409417
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37352008
144Thyroid hormone synthesis_Homo sapiens_hsa049180.37251442
145PPAR signaling pathway_Homo sapiens_hsa033200.36863593
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.36682115
147Thyroid cancer_Homo sapiens_hsa052160.36447754
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34659086
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34209078
150Ovarian steroidogenesis_Homo sapiens_hsa049130.33733581
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33639427
152Endocytosis_Homo sapiens_hsa041440.31995826
153Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31740306
154p53 signaling pathway_Homo sapiens_hsa041150.31186330
155Retinol metabolism_Homo sapiens_hsa008300.30959590
156Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30432773
157Glucagon signaling pathway_Homo sapiens_hsa049220.29989165
158Fatty acid elongation_Homo sapiens_hsa000620.29746411
159Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29678739
160Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29225336
161Renal cell carcinoma_Homo sapiens_hsa052110.29212977
162Pancreatic secretion_Homo sapiens_hsa049720.28825639
163Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27751327
164Dilated cardiomyopathy_Homo sapiens_hsa054140.26936081
165RNA transport_Homo sapiens_hsa030130.25719430
166Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22486889
167Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21986758
168Glycerophospholipid metabolism_Homo sapiens_hsa005640.21397974
169Non-small cell lung cancer_Homo sapiens_hsa052230.21217925

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