PLCG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of nucleus localization (GO:0040023)4.17877229
2paraxial mesoderm development (GO:0048339)3.99991358
3pyrimidine nucleobase catabolic process (GO:0006208)3.96149774
4pre-miRNA processing (GO:0031054)3.91976471
5regulation of histone H3-K27 methylation (GO:0061085)3.85109555
6axon extension involved in axon guidance (GO:0048846)3.56177999
7neuron projection extension involved in neuron projection guidance (GO:1902284)3.56177999
8coronary vasculature morphogenesis (GO:0060977)3.51124851
9regulation of T cell tolerance induction (GO:0002664)3.50743242
10peptidyl-lysine dimethylation (GO:0018027)3.33468624
11positive thymic T cell selection (GO:0045059)3.32941579
12positive regulation of histone deacetylation (GO:0031065)3.27306147
13positive T cell selection (GO:0043368)3.24684439
14planar cell polarity pathway involved in neural tube closure (GO:0090179)3.23927347
15regulation of NFAT protein import into nucleus (GO:0051532)3.21760089
16gastrulation with mouth forming second (GO:0001702)3.20802057
17positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.18602059
18histone H3-K36 demethylation (GO:0070544)3.16952985
19venous blood vessel morphogenesis (GO:0048845)3.16421406
20regulation of gamma-delta T cell differentiation (GO:0045586)3.15983966
21negative T cell selection (GO:0043383)3.15971337
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.14519194
23thymic T cell selection (GO:0045061)3.13935880
24basement membrane organization (GO:0071711)3.13598619
25epithelial cell differentiation involved in prostate gland development (GO:0060742)3.11784805
26convergent extension (GO:0060026)3.11681643
27NLS-bearing protein import into nucleus (GO:0006607)3.10026486
28glial cell proliferation (GO:0014009)3.09657303
29nucleobase catabolic process (GO:0046113)3.00756706
30positive regulation of RNA splicing (GO:0033120)2.99970369
31negative regulation of axon extension involved in axon guidance (GO:0048843)2.99019616
32positive regulation of tolerance induction (GO:0002645)2.98636214
33negative thymic T cell selection (GO:0045060)2.96254227
34embryonic foregut morphogenesis (GO:0048617)2.94207955
35cell migration involved in sprouting angiogenesis (GO:0002042)2.92510522
36apoptotic process involved in morphogenesis (GO:0060561)2.91988302
37stress granule assembly (GO:0034063)2.91005377
38insulin-like growth factor receptor signaling pathway (GO:0048009)2.89911252
39negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.89430077
40cell migration involved in heart development (GO:0060973)2.87246369
41dopaminergic neuron differentiation (GO:0071542)2.85744661
42T cell selection (GO:0045058)2.85628128
43regulation of mammary gland epithelial cell proliferation (GO:0033599)2.83066959
44regulation of fatty acid beta-oxidation (GO:0031998)2.82429084
45regulation of ARF protein signal transduction (GO:0032012)2.82223919
46cytoskeletal anchoring at plasma membrane (GO:0007016)2.81727653
47regulation of RNA export from nucleus (GO:0046831)2.80928373
48negative regulation of cell size (GO:0045792)2.79346621
49cytoplasmic mRNA processing body assembly (GO:0033962)2.79133567
50cell-substrate junction assembly (GO:0007044)2.78949332
51adherens junction assembly (GO:0034333)2.76959295
52nuclear pore complex assembly (GO:0051292)2.76872155
53regulation of gamma-delta T cell activation (GO:0046643)2.75928039
54layer formation in cerebral cortex (GO:0021819)2.75534733
55negative regulation of cell killing (GO:0031342)2.74392736
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.74392736
57positive regulation of glycogen biosynthetic process (GO:0045725)2.74193905
58embryonic camera-type eye morphogenesis (GO:0048596)2.73830274
59histone lysine demethylation (GO:0070076)2.73804731
60negative regulation of axon guidance (GO:1902668)2.73128333
61positive regulation of gamma-delta T cell activation (GO:0046645)2.72606458
62RNA stabilization (GO:0043489)2.72570079
63mRNA stabilization (GO:0048255)2.72570079
64nucleus localization (GO:0051647)2.72185520
65* cellular response to epidermal growth factor stimulus (GO:0071364)2.69533451
66negative regulation of glial cell proliferation (GO:0060253)2.68809355
67regulation of ARF GTPase activity (GO:0032312)2.68790996
68cardiac muscle cell proliferation (GO:0060038)2.67250924
69positive regulation of fatty acid beta-oxidation (GO:0032000)2.65428122
70dosage compensation (GO:0007549)2.65130462
71positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.63456701
72spliceosomal tri-snRNP complex assembly (GO:0000244)2.63160832
73hippo signaling (GO:0035329)2.63149834
74negative regulation of histone methylation (GO:0031061)2.61941560
75heterochromatin organization (GO:0070828)2.61430107
76protein-DNA complex disassembly (GO:0032986)2.59480748
77nucleosome disassembly (GO:0006337)2.59480748
78negative regulation of fatty acid transport (GO:2000192)2.59053116
79negative regulation of catenin import into nucleus (GO:0035414)2.58433507
80embryonic retina morphogenesis in camera-type eye (GO:0060059)2.55423784
81regulation of axon extension involved in axon guidance (GO:0048841)2.54595518
82maternal placenta development (GO:0001893)2.54051027
83embryonic eye morphogenesis (GO:0048048)2.53874944
84histone demethylation (GO:0016577)2.52199428
85regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.52010251
86negative regulation of erythrocyte differentiation (GO:0045647)2.51461374
87* response to epidermal growth factor (GO:0070849)2.50496008
88glucocorticoid receptor signaling pathway (GO:0042921)2.50380768
89embryonic process involved in female pregnancy (GO:0060136)2.49074039
90protein retention in ER lumen (GO:0006621)2.48833184
91cellular response to prostaglandin stimulus (GO:0071379)2.48472815
92neural tube development (GO:0021915)2.48472716
93cell migration in hindbrain (GO:0021535)2.48449799
94eye morphogenesis (GO:0048592)2.46745071
95DNA unwinding involved in DNA replication (GO:0006268)2.45948368
96regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.45399631
97regulation of translational fidelity (GO:0006450)2.44775580
98regulation of extracellular matrix organization (GO:1903053)2.44743231
99intracellular estrogen receptor signaling pathway (GO:0030520)2.43743816
100regulation of glucose import in response to insulin stimulus (GO:2001273)2.43558866
101regulation of axon guidance (GO:1902667)2.43068699
102positive regulation of synapse maturation (GO:0090129)2.42391858
103histone H4 deacetylation (GO:0070933)2.41841634
104G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.41588382
105morphogenesis of an endothelium (GO:0003159)2.41132846
106endothelial tube morphogenesis (GO:0061154)2.41132846
107cell-cell junction maintenance (GO:0045217)2.41124007
108negative regulation of RNA splicing (GO:0033119)2.40215726
109antigen processing and presentation via MHC class Ib (GO:0002475)2.40120278
110cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.39976812
111focal adhesion assembly (GO:0048041)2.39320872
112cell-substrate adherens junction assembly (GO:0007045)2.39320872
113mannose metabolic process (GO:0006013)2.37366497
114establishment of tissue polarity (GO:0007164)2.37095362
115establishment of planar polarity (GO:0001736)2.37095362
116regulation of extracellular matrix disassembly (GO:0010715)2.36955692
117COPI coating of Golgi vesicle (GO:0048205)2.36898322
118Golgi transport vesicle coating (GO:0048200)2.36898322
119histone H3-K9 demethylation (GO:0033169)2.36876375
120retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.33709092
121patterning of blood vessels (GO:0001569)2.33385734
122polarized epithelial cell differentiation (GO:0030859)2.33345318
123dorsal/ventral axis specification (GO:0009950)2.32692377
124ear development (GO:0043583)2.32672202
125maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.32261624
126alternative mRNA splicing, via spliceosome (GO:0000380)2.32087266
127negative regulation of mRNA processing (GO:0050686)2.31381007
128heart morphogenesis (GO:0003007)2.31262817
129activation of Rac GTPase activity (GO:0032863)2.30581111
130regulation of hippo signaling (GO:0035330)2.30523838
131striated muscle cell proliferation (GO:0014855)2.30397418
132blood vessel endothelial cell migration (GO:0043534)2.30068228
133regulation of nucleobase-containing compound transport (GO:0032239)2.29933855
134camera-type eye morphogenesis (GO:0048593)2.29855662
135regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.27564940
136semaphorin-plexin signaling pathway (GO:0071526)2.26739329
137plasma membrane repair (GO:0001778)2.25759345
138positive regulation of glycogen metabolic process (GO:0070875)2.25723162
139V(D)J recombination (GO:0033151)2.25577372
140collecting duct development (GO:0072044)2.25300363
141Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.24992742
142regulation of cholesterol homeostasis (GO:2000188)2.24675677
143ectodermal placode formation (GO:0060788)2.24490903
144regulation of establishment of planar polarity (GO:0090175)2.23567545
145regulation of somitogenesis (GO:0014807)2.21998051
146response to laminar fluid shear stress (GO:0034616)2.21981533
147signal complex assembly (GO:0007172)2.21976794
1483-UTR-mediated mRNA stabilization (GO:0070935)2.21050910
149positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.20854735
150positive regulation of gene expression, epigenetic (GO:0045815)2.20645084
151histone deubiquitination (GO:0016578)2.20559195
152negative regulation of myotube differentiation (GO:0010832)2.20257300
153mitotic chromosome condensation (GO:0007076)2.20133646
154synaptic vesicle docking involved in exocytosis (GO:0016081)2.19594361
155cerebellar granule cell differentiation (GO:0021707)2.19497315
156modulation by virus of host morphology or physiology (GO:0019048)2.17864108
157peptidyl-threonine phosphorylation (GO:0018107)2.16395085
158protein demethylation (GO:0006482)2.15745922
159protein dealkylation (GO:0008214)2.15745922
160protein export from nucleus (GO:0006611)2.15011378
161endothelial cell chemotaxis (GO:0035767)2.14790147
162regulation of early endosome to late endosome transport (GO:2000641)2.14047390
163lung epithelium development (GO:0060428)2.13980226
164cochlea morphogenesis (GO:0090103)2.13010453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.73159386
2MYC_22102868_ChIP-Seq_BL_Human3.37592404
3EGR1_19374776_ChIP-ChIP_THP-1_Human2.95413418
4ZFP281_18757296_ChIP-ChIP_E14_Mouse2.86311318
5KDM2B_26808549_Chip-Seq_DND41_Human2.83978272
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.75794211
7* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.69543516
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.60912490
9CLOCK_20551151_ChIP-Seq_293T_Human2.47418875
10ZFP281_27345836_Chip-Seq_ESCs_Mouse2.41916051
11KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.39805571
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.38280722
13* TCF7_22412390_ChIP-Seq_EML_Mouse2.36691721
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.31429951
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.29226174
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28024757
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.27513003
18KDM2B_26808549_Chip-Seq_JURKAT_Human2.24972078
19DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.22463215
20* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21605966
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.20065479
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.07190589
23KDM2B_26808549_Chip-Seq_K562_Human2.04983444
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04854776
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.96027691
26* ELK3_25401928_ChIP-Seq_HUVEC_Human1.95874032
27ZNF263_19887448_ChIP-Seq_K562_Human1.93140427
28* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.86779271
29* FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.85443066
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.78190505
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75655527
32LXR_22292898_ChIP-Seq_THP-1_Human1.73970285
33VDR_21846776_ChIP-Seq_THP-1_Human1.72219634
34E2F7_22180533_ChIP-Seq_HELA_Human1.66697148
35* UTX_26944678_Chip-Seq_JUKART_Human1.64865291
36* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.64700708
37* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.64296099
38* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.59875485
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55998583
40ISL1_27105846_Chip-Seq_CPCs_Mouse1.54538842
41DROSHA_22980978_ChIP-Seq_HELA_Human1.51732558
42RUNX_20019798_ChIP-Seq_JUKART_Human1.42498929
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41844460
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40851569
45* MAF_26560356_Chip-Seq_TH1_Human1.39692345
46CIITA_25753668_ChIP-Seq_RAJI_Human1.38459562
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38306314
48SMC4_20622854_ChIP-Seq_HELA_Human1.36420400
49* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36013490
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35291852
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.30541872
52* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29407227
53CREB1_26743006_Chip-Seq_LNCaP_Human1.28569232
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28148651
55TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26694336
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26144024
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25979435
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23818465
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22824876
60FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.22255083
61RACK7_27058665_Chip-Seq_MCF-7_Human1.20940279
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19619282
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19383396
64RARB_27405468_Chip-Seq_BRAIN_Mouse1.18919379
65FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.17865973
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17406182
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16315882
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15837233
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.14990377
70SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14559192
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13639297
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.13557191
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.13557191
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.12473782
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11287659
76POU5F1_16518401_ChIP-PET_MESCs_Mouse1.10381167
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09621595
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09297112
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09297112
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09297112
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.08255047
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08218827
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.07759204
84TP53_22127205_ChIP-Seq_IMR90_Human1.07611856
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07445166
86TRIM28_21343339_ChIP-Seq_HEK293_Human1.06812874
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05987781
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05430856
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03901934
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03764344
91EZH2_22144423_ChIP-Seq_EOC_Human1.03435833
92P68_20966046_ChIP-Seq_HELA_Human1.02613194
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02302498
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02179426
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02028305
96* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01990978
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01743929
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.01709291
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.01312850
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00955002
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00402000
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00248089
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.00173631
104FOXA2_19822575_ChIP-Seq_HepG2_Human0.99797711
105KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99553982
106RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99205200
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99044801
108RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98497365
109EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98497365
110* CTCF_27219007_Chip-Seq_Bcells_Human0.98465414
111HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98354767
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97797745
113MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96586175
114SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96405041
115UBF1/2_26484160_Chip-Seq_HMECs_Human0.95020095
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94556888
117TP53_20018659_ChIP-ChIP_R1E_Mouse0.94127321
118HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93450597
119NCOR1_26117541_ChIP-Seq_K562_Human0.93204376
120NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93092341
121PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91865084
122MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91765153
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90720401
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.90561066
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90379092
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90348225
127SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89616344
128MAF_26560356_Chip-Seq_TH2_Human0.88358099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.73889105
2MP0008961_abnormal_basal_metabolism3.53673398
3MP0005409_darkened_coat_color3.07935439
4MP0002653_abnormal_ependyma_morphology3.06131263
5MP0000537_abnormal_urethra_morphology2.65567815
6MP0000569_abnormal_digit_pigmentation2.38250430
7MP0005076_abnormal_cell_differentiation2.33957063
8MP0010030_abnormal_orbit_morphology2.31311179
9MP0010368_abnormal_lymphatic_system2.28097048
10MP0004858_abnormal_nervous_system2.22182455
11MP0001348_abnormal_lacrimal_gland2.14269771
12MP0004084_abnormal_cardiac_muscle2.10662426
13MP0004185_abnormal_adipocyte_glucose2.05796839
14MP0005257_abnormal_intraocular_pressure2.01224770
15MP0003122_maternal_imprinting1.98175644
16MP0005187_abnormal_penis_morphology1.98110424
17MP0004130_abnormal_muscle_cell1.95405038
18MP0000733_abnormal_muscle_development1.94931494
19MP0004381_abnormal_hair_follicle1.93852680
20MP0010234_abnormal_vibrissa_follicle1.87227545
21MP0009053_abnormal_anal_canal1.83430205
22MP0004233_abnormal_muscle_weight1.79326938
23MP0003119_abnormal_digestive_system1.76315527
24MP0005623_abnormal_meninges_morphology1.74765700
25MP0003763_abnormal_thymus_physiology1.73424286
26MP0003115_abnormal_respiratory_system1.69800834
27MP0005666_abnormal_adipose_tissue1.68811044
28MP0009278_abnormal_bone_marrow1.67382120
29MP0010352_gastrointestinal_tract_polyps1.65508951
30MP0003890_abnormal_embryonic-extraembry1.64430101
31MP0005670_abnormal_white_adipose1.63504215
32MP0008438_abnormal_cutaneous_collagen1.62187626
33MP0000751_myopathy1.59262841
34MP0003121_genomic_imprinting1.59158597
35MP0004197_abnormal_fetal_growth/weight/1.56889931
36MP0003091_abnormal_cell_migration1.54111567
37MP0004272_abnormal_basement_membrane1.52837186
38MP0001915_intracranial_hemorrhage1.52796848
39MP0005375_adipose_tissue_phenotype1.51620684
40MP0002084_abnormal_developmental_patter1.50126572
41MP0008260_abnormal_autophagy1.48607315
42MP0003283_abnormal_digestive_organ1.48159343
43MP0002009_preneoplasia1.47022642
44MP0004264_abnormal_extraembryonic_tissu1.45763883
45MP0003935_abnormal_craniofacial_develop1.44308890
46MP0005275_abnormal_skin_tensile1.43045972
47MP0003300_gastrointestinal_ulcer1.41945007
48MP0010630_abnormal_cardiac_muscle1.40461081
49MP0000003_abnormal_adipose_tissue1.40259627
50* MP0002925_abnormal_cardiovascular_devel1.38618550
51MP0003385_abnormal_body_wall1.38411132
52MP0002234_abnormal_pharynx_morphology1.38174827
53MP0002837_dystrophic_cardiac_calcinosis1.37789170
54MP0000778_abnormal_nervous_system1.36386963
55MP0009384_cardiac_valve_regurgitation1.35736239
56MP0001299_abnormal_eye_distance/1.34776465
57MP0003566_abnormal_cell_adhesion1.27054751
58MP0001879_abnormal_lymphatic_vessel1.25552451
59MP0000534_abnormal_ureter_morphology1.24787566
60MP0004859_abnormal_synaptic_plasticity1.24490332
61MP0003861_abnormal_nervous_system1.24381816
62MP0002932_abnormal_joint_morphology1.23774623
63MP0002085_abnormal_embryonic_tissue1.21008453
64MP0000579_abnormal_nail_morphology1.20956212
65MP0005451_abnormal_body_composition1.20409020
66MP0003279_aneurysm1.20375206
67MP0000566_synostosis1.20203296
68MP0000428_abnormal_craniofacial_morphol1.19550278
69MP0002396_abnormal_hematopoietic_system1.18468547
70* MP0002088_abnormal_embryonic_growth/wei1.18139960
71MP0003329_amyloid_beta_deposits1.16792732
72* MP0003984_embryonic_growth_retardation1.16517183
73MP0003942_abnormal_urinary_system1.16468842
74MP0004087_abnormal_muscle_fiber1.15804268
75MP0001346_abnormal_lacrimal_gland1.13141229
76* MP0002086_abnormal_extraembryonic_tissu1.12266532
77* MP0001730_embryonic_growth_arrest1.12218087
78* MP0000703_abnormal_thymus_morphology1.10348045
79* MP0005380_embryogenesis_phenotype1.10188976
80* MP0001672_abnormal_embryogenesis/_devel1.10188976
81MP0009672_abnormal_birth_weight1.07121596
82MP0000266_abnormal_heart_morphology1.06517066
83MP0003172_abnormal_lysosome_physiology1.04759591
84MP0003567_abnormal_fetal_cardiomyocyte1.04638070
85MP0002282_abnormal_trachea_morphology1.04622319
86MP0000432_abnormal_head_morphology1.03347934
87MP0008569_lethality_at_weaning1.02672959
88MP0001958_emphysema1.00695614
89MP0004808_abnormal_hematopoietic_stem1.00069369
90MP0002089_abnormal_postnatal_growth/wei0.98535449
91MP0002877_abnormal_melanocyte_morpholog0.96417948
92MP0003111_abnormal_nucleus_morphology0.96222829
93MP0002116_abnormal_craniofacial_bone0.96047433
94MP0003453_abnormal_keratinocyte_physiol0.94717439
95MP0003787_abnormal_imprinting0.94173828
96MP0006138_congestive_heart_failure0.93727917
97MP0008770_decreased_survivor_rate0.93662188
98MP0000767_abnormal_smooth_muscle0.93171535
99MP0000678_abnormal_parathyroid_gland0.92702559
100MP0002114_abnormal_axial_skeleton0.91869320
101MP0002108_abnormal_muscle_morphology0.91677311
102MP0009703_decreased_birth_body0.91282489
103MP0001697_abnormal_embryo_size0.91204947
104MP0002092_abnormal_eye_morphology0.90502566
105MP0005023_abnormal_wound_healing0.90318382
106MP0002697_abnormal_eye_size0.90161986
107MP0002166_altered_tumor_susceptibility0.89806701
108MP0003137_abnormal_impulse_conducting0.87902794
109MP0001784_abnormal_fluid_regulation0.87410656
110MP0000762_abnormal_tongue_morphology0.86759133
111MP0005621_abnormal_cell_physiology0.86749699
112MP0001340_abnormal_eyelid_morphology0.84836695
113MP0003634_abnormal_glial_cell0.84687953
114MP0002128_abnormal_blood_circulation0.84459322
115MP0009780_abnormal_chondrocyte_physiolo0.84419529
116MP0002081_perinatal_lethality0.83529425
117MP0001270_distended_abdomen0.83064995
118MP0000467_abnormal_esophagus_morphology0.80726379
119MP0005385_cardiovascular_system_phenoty0.79406994
120MP0001544_abnormal_cardiovascular_syste0.79406994
121MP0004133_heterotaxia0.79151435
122MP0005423_abnormal_somatic_nervous0.78977195
123MP0002249_abnormal_larynx_morphology0.78908189
124MP0001286_abnormal_eye_development0.77595856
125MP0003315_abnormal_perineum_morphology0.77498483
126MP0000371_diluted_coat_color0.77002536
127MP0002152_abnormal_brain_morphology0.76410721
128MP0010678_abnormal_skin_adnexa0.75139824
129MP0000350_abnormal_cell_proliferation0.74820833
130MP0003123_paternal_imprinting0.74586943
131* MP0001849_ear_inflammation0.74314653
132* MP0002080_prenatal_lethality0.74294501
133* MP0001614_abnormal_blood_vessel0.74151322

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.97446544
2Short 4th metacarpal (HP:0010044)3.82042225
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.82042225
4Cerebral aneurysm (HP:0004944)3.81566873
5Shallow orbits (HP:0000586)3.41800478
6Abnormality of the 4th metacarpal (HP:0010012)3.35624035
7Asymmetry of the thorax (HP:0001555)3.27417345
8Elfin facies (HP:0004428)3.14069630
9Renal duplication (HP:0000075)3.03686811
10Obstructive sleep apnea (HP:0002870)3.03527628
11Broad metatarsal (HP:0001783)2.98094322
12Broad face (HP:0000283)2.90420828
13Renovascular hypertension (HP:0100817)2.87681063
14Deep venous thrombosis (HP:0002625)2.83003887
15Lymphangioma (HP:0100764)2.73351974
16Overriding aorta (HP:0002623)2.62348259
17Aortic aneurysm (HP:0004942)2.60617995
18Macroorchidism (HP:0000053)2.57533371
19Trigonocephaly (HP:0000243)2.53964748
20Neoplasm of the heart (HP:0100544)2.51029639
21Obsessive-compulsive behavior (HP:0000722)2.49047429
22Wrist flexion contracture (HP:0001239)2.48758433
23Bowel diverticulosis (HP:0005222)2.48638706
24Flat acetabular roof (HP:0003180)2.47529027
25Pointed chin (HP:0000307)2.45284782
26Difficulty running (HP:0009046)2.44964463
27Dislocated radial head (HP:0003083)2.41440688
28Bladder diverticulum (HP:0000015)2.38957052
29Abnormality of oral frenula (HP:0000190)2.38281574
30Insomnia (HP:0100785)2.35698597
31Ependymoma (HP:0002888)2.34548064
32Protrusio acetabuli (HP:0003179)2.31976250
33Abnormality of the distal phalanx of the thumb (HP:0009617)2.31276401
34Heterotopia (HP:0002282)2.30497000
35Mitral valve prolapse (HP:0001634)2.29942699
36Aneurysm (HP:0002617)2.28887884
37Abnormality of the radial head (HP:0003995)2.27787665
38Increased nuchal translucency (HP:0010880)2.26926731
39Dilatation of the ascending aorta (HP:0005111)2.26125973
40Ankle contracture (HP:0006466)2.25519292
41Flat cornea (HP:0007720)2.22471812
42Thin ribs (HP:0000883)2.21493353
43Abnormality of the lower motor neuron (HP:0002366)2.21331067
44Astrocytoma (HP:0009592)2.20471904
45Abnormality of the astrocytes (HP:0100707)2.20471904
46Ankyloglossia (HP:0010296)2.17553573
47Deviation of the hallux (HP:0010051)2.16033800
48Hallux valgus (HP:0001822)2.15180509
49Biconcave vertebral bodies (HP:0004586)2.14862497
50Narrow palate (HP:0000189)2.14698002
51Syringomyelia (HP:0003396)2.09264716
52Spinal cord lesions (HP:0100561)2.09264716
53Premature rupture of membranes (HP:0001788)2.08068698
54Metaphyseal cupping (HP:0003021)2.06654383
55Abnormality of the fingertips (HP:0001211)2.06460716
56Abnormality of the intervertebral disk (HP:0005108)2.03935568
57Cutis marmorata (HP:0000965)2.01975501
58Sacral dimple (HP:0000960)2.01534221
59Skull defect (HP:0001362)2.00421528
60Bicuspid aortic valve (HP:0001647)1.98942479
61Pseudobulbar signs (HP:0002200)1.98849913
62Mitral regurgitation (HP:0001653)1.98829940
63Striae distensae (HP:0001065)1.97716774
64Long eyelashes (HP:0000527)1.92978089
65Long palpebral fissure (HP:0000637)1.92823981
66Abnormality of the humeroradial joint (HP:0100744)1.91275984
67Vascular tortuosity (HP:0004948)1.90877858
68Disproportionate tall stature (HP:0001519)1.89524352
69Thin bony cortex (HP:0002753)1.89495407
70Broad palm (HP:0001169)1.88502735
71Subacute progressive viral hepatitis (HP:0006572)1.87356132
72Enlarged penis (HP:0000040)1.86698958
73High pitched voice (HP:0001620)1.85927612
74Supernumerary ribs (HP:0005815)1.85747422
75Germ cell neoplasia (HP:0100728)1.84467466
76Spina bifida occulta (HP:0003298)1.84137857
77Abnormality of the diencephalon (HP:0010662)1.84080055
78Aortic dissection (HP:0002647)1.80926959
79Proximal placement of thumb (HP:0009623)1.80326919
80Long toe (HP:0010511)1.79951885
81Megalocornea (HP:0000485)1.79521346
82Cervical subluxation (HP:0003308)1.79075814
83Exotropia (HP:0000577)1.78491400
84Neonatal short-limb short stature (HP:0008921)1.78014933
85Deviation of the thumb (HP:0009603)1.74784139
86Precocious puberty (HP:0000826)1.74604030
87High anterior hairline (HP:0009890)1.74037573
88Broad phalanges of the hand (HP:0009768)1.74014321
89Hyporeflexia of lower limbs (HP:0002600)1.73811680
90Cupped ribs (HP:0000887)1.73241757
91Increased density of long bones (HP:0006392)1.72797124
92Fibroma (HP:0010614)1.72164858
93Abnormality of the aortic arch (HP:0012303)1.72100441
94Abnormal ossification of hand bones (HP:0005921)1.72010973
95Abnormality of the calcaneus (HP:0008364)1.71921496
96Fibrous tissue neoplasm (HP:0012316)1.71429806
97T lymphocytopenia (HP:0005403)1.70889027
98Limited elbow extension (HP:0001377)1.70869292
99Hepatoblastoma (HP:0002884)1.68594031
100Arnold-Chiari malformation (HP:0002308)1.67486607
101Wide anterior fontanel (HP:0000260)1.67404801
102Broad finger (HP:0001500)1.67270527
103Advanced eruption of teeth (HP:0006288)1.66472583
104Turricephaly (HP:0000262)1.65357912
105Increased variability in muscle fiber diameter (HP:0003557)1.65075149
106Hypopigmentation of the fundus (HP:0007894)1.65022996
107Partial duplication of thumb phalanx (HP:0009944)1.64217748
108Ventricular tachycardia (HP:0004756)1.64100417
109Visceral angiomatosis (HP:0100761)1.62748051
110Abnormal vertebral ossification (HP:0100569)1.61901825
111Broad thumb (HP:0011304)1.61445592
112Ulnar bowing (HP:0003031)1.61361652
113Increased connective tissue (HP:0009025)1.60712001
114Rib fusion (HP:0000902)1.60424536
115Genu recurvatum (HP:0002816)1.60231186
116Volvulus (HP:0002580)1.59788022
117Exostoses (HP:0100777)1.59405534
118Skin tags (HP:0010609)1.59355926
119Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59186540
120Deep palmar crease (HP:0006191)1.59116539
121Hemorrhage of the eye (HP:0011885)1.58780496
122Joint laxity (HP:0001388)1.58573461
123Cortical dysplasia (HP:0002539)1.57921968
124Patellar dislocation (HP:0002999)1.57666245
125Hemiplegia (HP:0002301)1.57543300
126Bronchomalacia (HP:0002780)1.57036606
127Rectal prolapse (HP:0002035)1.56853561
128Vertebral arch anomaly (HP:0008438)1.56034602
129Hypoplastic labia majora (HP:0000059)1.55833551
130Camptodactyly of toe (HP:0001836)1.54951440
131Hemangiomatosis (HP:0007461)1.54812371
132Aplasia involving bones of the upper limbs (HP:0009823)1.54600244
133Aplasia of the phalanges of the hand (HP:0009802)1.54600244
134Aplasia involving bones of the extremities (HP:0009825)1.54600244
135Premature skin wrinkling (HP:0100678)1.54164137
136Tracheomalacia (HP:0002779)1.54150455
137Hematochezia (HP:0002573)1.53820456
138Partial duplication of the phalanx of hand (HP:0009999)1.53293106
139Basal cell carcinoma (HP:0002671)1.52966129
140Buphthalmos (HP:0000557)1.52715783
141Ulnar deviation of finger (HP:0009465)1.52608821
142Anal stenosis (HP:0002025)1.52476822
143Blue sclerae (HP:0000592)1.52174395
144Short phalanx of the thumb (HP:0009660)1.52167962
145Vitreoretinal degeneration (HP:0000655)1.51875318
146Small epiphyses (HP:0010585)1.51803925
147Sudden death (HP:0001699)1.50663628
148Abnormality of the phalanges of the hallux (HP:0010057)1.50652707
149Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.50551690
150Urethral obstruction (HP:0000796)1.50098751
151Right ventricular cardiomyopathy (HP:0011663)1.49892446
152Arterial tortuosity (HP:0005116)1.49592489
153Annular pancreas (HP:0001734)1.49265949
154Dysmetric saccades (HP:0000641)1.49223000
155Leiomyosarcoma (HP:0100243)1.49129415
156Uterine leiomyosarcoma (HP:0002891)1.49129415
157Broad phalanx (HP:0006009)1.49091721

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.57958360
2MAP3K103.98894907
3EEF2K3.66320218
4PKN23.30590500
5SMG13.23715464
6CDK122.76556992
7PRPF4B2.54246009
8ICK2.44682487
9TTN2.07091682
10SIK11.91456433
11SIK31.87318880
12SIK21.86897404
13BRD41.82811801
14TIE11.82572006
15TGFBR11.75257204
16RIPK11.69533463
17PTK61.67897248
18KSR11.61735528
19CAMK1G1.61017779
20TGFBR21.59158235
21MARK11.58620440
22CAMK1D1.50265660
23* PDGFRA1.47238236
24NTRK11.44543610
25EPHB21.44438715
26MAP3K91.41288349
27DDR21.39323082
28KSR21.33894365
29MTOR1.31877791
30MAP3K71.30941215
31MAP3K131.29381016
32DMPK1.29367131
33CAMKK11.17941342
34LRRK21.11449389
35UHMK11.07399206
36PASK1.06145399
37PRKCH1.04468270
38MAP4K11.03309590
39* FGFR11.00634369
40PAK60.97598060
41* TYRO30.94321455
42WNK10.91098936
43MARK20.89588943
44RPS6KA20.87932414
45PAK30.86920764
46STK100.85722702
47PRKD30.85202736
48SGK4940.85062014
49SGK2230.85062014
50PTK20.83735225
51CDK60.83349851
52ZAP700.82604308
53CDK70.82436334
54ALK0.81331455
55NEK60.78751412
56DYRK1B0.78037562
57EPHB10.77789451
58GRK60.77241369
59ERN10.77222340
60* PDGFRB0.76867022
61NEK20.76701340
62NEK10.76258638
63CDK40.74927874
64CDC42BPA0.74378075
65FER0.73462105
66BCR0.73155576
67PAK20.71174112
68MELK0.69244860
69PDPK10.69139926
70MAP3K60.68497430
71ERBB20.67185991
72LATS10.65787207
73MAP2K30.65780878
74ILK0.65301292
75MAPK100.64251201
76MINK10.64165017
77RPS6KL10.63050308
78RPS6KC10.63050308
79CAMK40.62393343
80NTRK30.62168730
81EPHA30.61419760
82JAK30.60818265
83AKT20.59920873
84PAK40.59275685
85SGK20.59039666
86CDK90.58917201
87LMTK20.57106233
88* ITK0.55807620
89KDR0.55402478
90CSNK1A1L0.55190759
91MAP2K20.55014343
92NLK0.54677660
93LATS20.53752589
94BRSK10.53703773
95RPS6KB20.53393115
96PDK10.53145750
97BMX0.52596787
98MAPK120.50238142
99* RET0.50042531
100CSNK1D0.49997002
101MAPK110.48363463
102ROCK10.48123225
103* FGFR30.47151932
104CDK11A0.46500926
105MAP3K10.46310116
106CDK150.46195644
107RPS6KB10.45407088
108MAPK90.45262786
109* FGFR40.44833717
110RPS6KA10.42540422
111ROCK20.42135502
112* PRKD10.41628364
113CDC70.41014084
114RPS6KA60.40288394
115CDK180.40279303
116TAOK10.39926687
117JAK20.39880370
118PRKD20.39265751
119MAPK80.38942506
120JAK10.38926026
121TAOK20.38755919
122GSK3B0.38622538
123STK110.38512568
124CDK10.38448917
125CHEK10.38273889
126* SRC0.37825309
127STK380.36402037
128TXK0.35999697
129SCYL20.35526585
130HIPK20.34641448
131MAPK70.34619331
132SGK30.34223485
133CDK20.33852967
134FYN0.33692448
135MAP3K40.33126288
136CSNK1G10.32380157
137MAPK140.32250437

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043302.26786375
2Basal cell carcinoma_Homo sapiens_hsa052172.03177404
3Lysine degradation_Homo sapiens_hsa003102.02469016
4Chronic myeloid leukemia_Homo sapiens_hsa052201.86151817
5mTOR signaling pathway_Homo sapiens_hsa041501.65856778
6Colorectal cancer_Homo sapiens_hsa052101.65593871
7* T cell receptor signaling pathway_Homo sapiens_hsa046601.64449341
8Adherens junction_Homo sapiens_hsa045201.59858817
9Viral myocarditis_Homo sapiens_hsa054161.53498921
10Nitrogen metabolism_Homo sapiens_hsa009101.53104937
11Endometrial cancer_Homo sapiens_hsa052131.52810681
12Hippo signaling pathway_Homo sapiens_hsa043901.51266609
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46609677
14Axon guidance_Homo sapiens_hsa043601.46222185
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41393301
16* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.38691986
17* Proteoglycans in cancer_Homo sapiens_hsa052051.38159919
18Insulin resistance_Homo sapiens_hsa049311.37034096
19Focal adhesion_Homo sapiens_hsa045101.34571669
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31268522
21* MicroRNAs in cancer_Homo sapiens_hsa052061.31112838
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29840205
23Long-term potentiation_Homo sapiens_hsa047201.28704167
24Hedgehog signaling pathway_Homo sapiens_hsa043401.25954949
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23575493
26Small cell lung cancer_Homo sapiens_hsa052221.23565998
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.20948027
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.20241249
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19365560
30Renal cell carcinoma_Homo sapiens_hsa052111.18685203
31Prion diseases_Homo sapiens_hsa050201.18343404
32Dilated cardiomyopathy_Homo sapiens_hsa054141.15883826
33AMPK signaling pathway_Homo sapiens_hsa041521.13717652
34Dorso-ventral axis formation_Homo sapiens_hsa043201.13033727
35Pancreatic cancer_Homo sapiens_hsa052121.12959686
36Insulin signaling pathway_Homo sapiens_hsa049101.11704234
37Primary immunodeficiency_Homo sapiens_hsa053401.10863867
38HTLV-I infection_Homo sapiens_hsa051661.10472566
39* VEGF signaling pathway_Homo sapiens_hsa043701.08612104
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08350638
41Estrogen signaling pathway_Homo sapiens_hsa049151.07028845
42Wnt signaling pathway_Homo sapiens_hsa043101.06273338
43Type II diabetes mellitus_Homo sapiens_hsa049301.04671784
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04543399
45* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03826657
46* Non-small cell lung cancer_Homo sapiens_hsa052231.03709336
47* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02954337
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02577725
49B cell receptor signaling pathway_Homo sapiens_hsa046621.02362342
50mRNA surveillance pathway_Homo sapiens_hsa030151.02292143
51* Inositol phosphate metabolism_Homo sapiens_hsa005620.99274399
52Melanogenesis_Homo sapiens_hsa049160.99181393
53* Neurotrophin signaling pathway_Homo sapiens_hsa047220.98533041
54Other glycan degradation_Homo sapiens_hsa005110.98445219
55* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97790905
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97686712
57* Rap1 signaling pathway_Homo sapiens_hsa040150.95490430
58ECM-receptor interaction_Homo sapiens_hsa045120.93386408
59Acute myeloid leukemia_Homo sapiens_hsa052210.92877238
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91912796
61Gap junction_Homo sapiens_hsa045400.91286467
62* Pathways in cancer_Homo sapiens_hsa052000.89551009
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89404067
64* Glioma_Homo sapiens_hsa052140.88959189
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87264941
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86508168
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86335714
68Glucagon signaling pathway_Homo sapiens_hsa049220.85631811
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85369852
70Platelet activation_Homo sapiens_hsa046110.84937627
71* ErbB signaling pathway_Homo sapiens_hsa040120.84233555
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81240836
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.80300780
74FoxO signaling pathway_Homo sapiens_hsa040680.79023966
75* Leukocyte transendothelial migration_Homo sapiens_hsa046700.78336710
76GnRH signaling pathway_Homo sapiens_hsa049120.77934019
77TGF-beta signaling pathway_Homo sapiens_hsa043500.77852145
78Oxytocin signaling pathway_Homo sapiens_hsa049210.77736057
79Bladder cancer_Homo sapiens_hsa052190.77259926
80Tight junction_Homo sapiens_hsa045300.75403959
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72820513
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72744881
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72731717
84* HIF-1 signaling pathway_Homo sapiens_hsa040660.71776583
85Thyroid hormone synthesis_Homo sapiens_hsa049180.71692579
86Prolactin signaling pathway_Homo sapiens_hsa049170.70369140
87Fatty acid metabolism_Homo sapiens_hsa012120.69828147
88Renin secretion_Homo sapiens_hsa049240.69585598
89Cholinergic synapse_Homo sapiens_hsa047250.67911198
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.67907543
91* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67417803
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66430225
93* Phospholipase D signaling pathway_Homo sapiens_hsa040720.66146424
94MAPK signaling pathway_Homo sapiens_hsa040100.65960473
95* Choline metabolism in cancer_Homo sapiens_hsa052310.65541210
96Melanoma_Homo sapiens_hsa052180.65513384
97Arginine biosynthesis_Homo sapiens_hsa002200.65189024
98Hepatitis B_Homo sapiens_hsa051610.64867775
99Prostate cancer_Homo sapiens_hsa052150.64692905
100Toxoplasmosis_Homo sapiens_hsa051450.62676976
101Viral carcinogenesis_Homo sapiens_hsa052030.62173663
102Endocytosis_Homo sapiens_hsa041440.60759276
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60619199
104Cell cycle_Homo sapiens_hsa041100.59414454
105* Ras signaling pathway_Homo sapiens_hsa040140.59393852
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56880232
107Fatty acid biosynthesis_Homo sapiens_hsa000610.56628031
108Fatty acid degradation_Homo sapiens_hsa000710.55583788
109Thyroid cancer_Homo sapiens_hsa052160.55337948
110Hepatitis C_Homo sapiens_hsa051600.55220546
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55188163
112PPAR signaling pathway_Homo sapiens_hsa033200.55056489
113Dopaminergic synapse_Homo sapiens_hsa047280.54107159
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.53084320
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52923214
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51975339
117Oocyte meiosis_Homo sapiens_hsa041140.51952509
118Amoebiasis_Homo sapiens_hsa051460.50759118
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50758284
120Apoptosis_Homo sapiens_hsa042100.50380781

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