PLBD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.68001375
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.31297327
3L-phenylalanine metabolic process (GO:0006558)4.31297327
4alpha-linolenic acid metabolic process (GO:0036109)4.31140521
5L-phenylalanine catabolic process (GO:0006559)4.30782363
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.30782363
7peptidyl-glutamic acid carboxylation (GO:0017187)4.28403211
8protein carboxylation (GO:0018214)4.28403211
9skin morphogenesis (GO:0043589)4.21068204
10adhesion of symbiont to host (GO:0044406)4.09642442
11negative regulation of fibrinolysis (GO:0051918)3.98160045
12sulfur amino acid catabolic process (GO:0000098)3.85542985
13plasma lipoprotein particle clearance (GO:0034381)3.84013022
14virion attachment to host cell (GO:0019062)3.78460337
15adhesion of symbiont to host cell (GO:0044650)3.78460337
16complement activation, alternative pathway (GO:0006957)3.74608767
17regulation of protein activation cascade (GO:2000257)3.71014279
18high-density lipoprotein particle remodeling (GO:0034375)3.70604587
19protein retention in ER lumen (GO:0006621)3.68961026
20reverse cholesterol transport (GO:0043691)3.68071564
21aromatic amino acid family catabolic process (GO:0009074)3.65421801
22barbed-end actin filament capping (GO:0051016)3.64862170
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.58690278
24regulation of complement activation (GO:0030449)3.58433776
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.56895856
26lysine metabolic process (GO:0006553)3.56889086
27lysine catabolic process (GO:0006554)3.56889086
28kynurenine metabolic process (GO:0070189)3.56010580
29endodermal cell differentiation (GO:0035987)3.55787524
30basement membrane organization (GO:0071711)3.53750360
31protein localization to endosome (GO:0036010)3.52338171
32cell adhesion mediated by integrin (GO:0033627)3.51458244
33bile acid biosynthetic process (GO:0006699)3.50870712
34glyoxylate metabolic process (GO:0046487)3.50164714
35urea metabolic process (GO:0019627)3.50114622
36urea cycle (GO:0000050)3.50114622
37cysteine metabolic process (GO:0006534)3.47060147
38regulation of fibrinolysis (GO:0051917)3.46826198
39regulation of early endosome to late endosome transport (GO:2000641)3.45527798
40cellular modified amino acid catabolic process (GO:0042219)3.42387893
41amino-acid betaine metabolic process (GO:0006577)3.40136959
42protein heterotrimerization (GO:0070208)3.39465375
43regulation of cholesterol homeostasis (GO:2000188)3.38488021
44stress fiber assembly (GO:0043149)3.38202028
45positive regulation of fatty acid beta-oxidation (GO:0032000)3.37926770
46low-density lipoprotein particle clearance (GO:0034383)3.35480337
47regulation of triglyceride catabolic process (GO:0010896)3.34785477
48apoptotic cell clearance (GO:0043277)3.28188066
49plasma lipoprotein particle remodeling (GO:0034369)3.27586257
50protein-lipid complex remodeling (GO:0034368)3.27586257
51macromolecular complex remodeling (GO:0034367)3.27586257
52phospholipid efflux (GO:0033700)3.25944805
53regulation of cholesterol esterification (GO:0010872)3.25503009
54positive regulation of lipid catabolic process (GO:0050996)3.25419459
55negative regulation of sterol transport (GO:0032372)3.25217870
56negative regulation of cholesterol transport (GO:0032375)3.25217870
57regulation of fatty acid beta-oxidation (GO:0031998)3.22641900
58nitrogen cycle metabolic process (GO:0071941)3.22611447
59collagen fibril organization (GO:0030199)3.18513787
60positive regulation of extracellular matrix organization (GO:1903055)3.18268512
61dicarboxylic acid biosynthetic process (GO:0043650)3.16654407
62indole-containing compound catabolic process (GO:0042436)3.12425384
63indolalkylamine catabolic process (GO:0046218)3.12425384
64tryptophan catabolic process (GO:0006569)3.12425384
65peptidyl-proline hydroxylation (GO:0019511)3.11445107
66substrate-dependent cell migration (GO:0006929)3.11328629
67kidney mesenchyme development (GO:0072074)3.08578383
68cortical actin cytoskeleton organization (GO:0030866)3.08166846
69regulation of cholesterol storage (GO:0010885)3.06570589
70chondrocyte proliferation (GO:0035988)3.05516773
71endothelial cell chemotaxis (GO:0035767)3.03023350
72positive regulation of triglyceride metabolic process (GO:0090208)3.02395214
73cholesterol efflux (GO:0033344)3.02178055
74cytoskeletal anchoring at plasma membrane (GO:0007016)3.01282826
75metanephric mesenchyme development (GO:0072075)3.00699426
76positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.00208721
77homocysteine metabolic process (GO:0050667)2.99578861
78regulation of extracellular matrix disassembly (GO:0010715)2.99433992
79hyaluronan catabolic process (GO:0030214)2.98831558
80fibrinolysis (GO:0042730)2.96932254
81serine family amino acid catabolic process (GO:0009071)2.95299296
82bile acid metabolic process (GO:0008206)2.92799047
83tryptophan metabolic process (GO:0006568)2.92516711
84coenzyme catabolic process (GO:0009109)2.92353411
85keratan sulfate catabolic process (GO:0042340)2.91949619
86protein-lipid complex assembly (GO:0065005)2.91440195
87positive regulation of fatty acid biosynthetic process (GO:0045723)2.91346158
88positive regulation of triglyceride biosynthetic process (GO:0010867)2.89585936
89regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.89040671
90protein hydroxylation (GO:0018126)2.87085748
91collagen metabolic process (GO:0032963)2.86818565
92aspartate family amino acid catabolic process (GO:0009068)2.86106620
93positive regulation of hemostasis (GO:1900048)2.84937609
94positive regulation of blood coagulation (GO:0030194)2.84937609
95endocytic recycling (GO:0032456)2.84292193
96phospholipid homeostasis (GO:0055091)2.84169583
97semaphorin-plexin signaling pathway (GO:0071526)2.83862804
98ethanol oxidation (GO:0006069)2.83349683
99plasma lipoprotein particle assembly (GO:0034377)2.83009635
100acylglycerol homeostasis (GO:0055090)2.82911449
101triglyceride homeostasis (GO:0070328)2.82911449
102glutamate metabolic process (GO:0006536)2.82719511
103carnitine metabolic process (GO:0009437)2.82371811
1042-oxoglutarate metabolic process (GO:0006103)2.82069641
105collagen catabolic process (GO:0030574)2.81595964
106cortical cytoskeleton organization (GO:0030865)2.79555942
107positive regulation of fatty acid oxidation (GO:0046321)2.78512018
108epoxygenase P450 pathway (GO:0019373)2.78361282
109alpha-amino acid catabolic process (GO:1901606)2.77971147
110regulation of membrane protein ectodomain proteolysis (GO:0051043)2.76589804
111complement activation (GO:0006956)2.76488229
112regulation of plasminogen activation (GO:0010755)2.76264615
113low-density lipoprotein particle remodeling (GO:0034374)2.74617689
114complement activation, classical pathway (GO:0006958)2.74611932
115alanine transport (GO:0032328)2.74557503
116regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.74319953
117protein-lipid complex subunit organization (GO:0071825)2.71804627
118regulation of apoptotic process involved in morphogenesis (GO:1902337)2.71802344
119positive regulation of coagulation (GO:0050820)2.71796868
120vascular endothelial growth factor signaling pathway (GO:0038084)2.70007826
121dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.69543016
122glycosphingolipid catabolic process (GO:0046479)2.69033875
123retina vasculature morphogenesis in camera-type eye (GO:0061299)2.67827573
124lipoprotein metabolic process (GO:0042157)2.67652791
125positive regulation of lipoprotein lipase activity (GO:0051006)2.67577840
126positive regulation of triglyceride lipase activity (GO:0061365)2.67577840
127cellular amino acid catabolic process (GO:0009063)2.67410897
128regulation of triglyceride metabolic process (GO:0090207)2.67170023
129extracellular matrix disassembly (GO:0022617)2.66347854
130positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.66212246
131plasma lipoprotein particle organization (GO:0071827)2.65799106
132positive regulation of axon extension (GO:0045773)2.65743256
133COPI coating of Golgi vesicle (GO:0048205)2.65276005
134Golgi transport vesicle coating (GO:0048200)2.65276005
135positive regulation of fatty acid metabolic process (GO:0045923)2.65047489
136multicellular organismal macromolecule metabolic process (GO:0044259)2.64889298
137regulation of cholesterol biosynthetic process (GO:0045540)2.64006736
138tooth mineralization (GO:0034505)2.63792300
139regulation of triglyceride biosynthetic process (GO:0010866)2.63401610
140mannose metabolic process (GO:0006013)2.63379213
1414-hydroxyproline metabolic process (GO:0019471)2.60698995
142protein activation cascade (GO:0072376)2.59700841
143acute-phase response (GO:0006953)2.58411507
144cell-substrate junction assembly (GO:0007044)2.57982105
145cofactor catabolic process (GO:0051187)2.57669889
146glial cell migration (GO:0008347)2.56881511
147short-chain fatty acid metabolic process (GO:0046459)2.56595985
148vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.55874031
149cellular response to thyroid hormone stimulus (GO:0097067)2.54572307
150multicellular organismal catabolic process (GO:0044243)2.54170819
151positive regulation of receptor recycling (GO:0001921)2.54065087
152chondroitin sulfate catabolic process (GO:0030207)2.54039081
153cell migration involved in heart development (GO:0060973)2.53937142
154negative regulation of smooth muscle cell migration (GO:0014912)2.51059450
155tachykinin receptor signaling pathway (GO:0007217)2.49026712
156positive regulation of endothelial cell apoptotic process (GO:2000353)2.47812237
157multicellular organismal metabolic process (GO:0044236)2.46841836
158venous blood vessel morphogenesis (GO:0048845)2.46009017
159decidualization (GO:0046697)2.45267084
160negative regulation of fatty acid transport (GO:2000192)2.41148110
161serine transport (GO:0032329)2.41046599
162extracellular matrix assembly (GO:0085029)2.39370822
163type B pancreatic cell proliferation (GO:0044342)2.39156941
164glycosaminoglycan catabolic process (GO:0006027)2.38191003
165insulin-like growth factor receptor signaling pathway (GO:0048009)2.37753833
166negative regulation of focal adhesion assembly (GO:0051895)2.37498023
167negative regulation of cell junction assembly (GO:1901889)2.37498023
168negative regulation of adherens junction organization (GO:1903392)2.37498023
169positive regulation of blood vessel endothelial cell migration (GO:0043536)2.37108245
170response to thyroid hormone (GO:0097066)2.36733586
171adherens junction assembly (GO:0034333)2.36240887
172planar cell polarity pathway involved in neural tube closure (GO:0090179)2.35944796
173glycolipid catabolic process (GO:0019377)2.35029286
174mesenchymal cell differentiation involved in kidney development (GO:0072161)2.34655908
175mesenchymal cell differentiation involved in renal system development (GO:2001012)2.34655908
176positive regulation of digestive system process (GO:0060456)2.33430164
177pinocytosis (GO:0006907)2.32122958
178cell-cell junction maintenance (GO:0045217)2.31702752
179epithelial cell-cell adhesion (GO:0090136)2.31491618
180cellular copper ion homeostasis (GO:0006878)2.31486272
181oligosaccharide catabolic process (GO:0009313)2.31141019
182L-serine transport (GO:0015825)2.30379245
183regulation of extracellular matrix organization (GO:1903053)2.29705420
184regulation of apoptotic cell clearance (GO:2000425)2.29158367
185glomerular basement membrane development (GO:0032836)2.28853415
186embryo implantation (GO:0007566)2.28848530
187hemidesmosome assembly (GO:0031581)2.28202401
188extracellular fibril organization (GO:0043206)2.27193813
189mating behavior (GO:0007617)2.25596791
190response to acidic pH (GO:0010447)2.25090266

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.53200825
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.66270732
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.24512144
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.06208049
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.71594349
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.06413993
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.06080762
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.76403026
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.45880625
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.24216166
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.23074536
12CLOCK_20551151_ChIP-Seq_293T_Human2.17715671
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.14038670
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.05350333
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03011153
16LXR_22292898_ChIP-Seq_THP-1_Human1.95450827
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76321763
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71869074
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68700600
20NFIB_24661679_ChIP-Seq_LUNG_Mouse1.68013255
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65162041
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.61458260
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55988742
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53004305
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48652673
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45251795
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44765479
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.42292646
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.41737981
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39400261
31RACK7_27058665_Chip-Seq_MCF-7_Human1.38856616
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35353195
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34761647
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34736047
35TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33459981
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32588098
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32588098
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32188968
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31861634
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.28649225
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27721072
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26575312
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.26493219
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.23727597
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22868560
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22208502
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.21059492
48SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20509957
49UBF1/2_26484160_Chip-Seq_HMECs_Human1.20369490
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18554377
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18266051
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17857936
53ZNF263_19887448_ChIP-Seq_K562_Human1.17855992
54KDM2B_26808549_Chip-Seq_K562_Human1.17085743
55TCF7_22412390_ChIP-Seq_EML_Mouse1.14715111
56TP53_23651856_ChIP-Seq_MEFs_Mouse1.13578783
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12995608
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12456598
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12437279
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12074750
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09562019
62EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06381503
63TET1_21490601_ChIP-Seq_MESCs_Mouse1.06224233
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05740411
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.04701071
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04439236
67JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02914184
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.02776733
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.02776733
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02254934
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.02227644
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02186248
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.01819469
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99791888
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99101483
76ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98544408
77KDM2B_26808549_Chip-Seq_DND41_Human0.98510393
78VDR_21846776_ChIP-Seq_THP-1_Human0.98369657
79PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98079781
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97870560
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97608493
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96835673
83FOXO3_23340844_ChIP-Seq_DLD1_Human0.96150391
84BRD4_25478319_ChIP-Seq_HGPS_Human0.94964754
85ATF3_27146783_Chip-Seq_COLON_Human0.94264372
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94091467
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93997868
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93741482
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93703369
90* DROSHA_22980978_ChIP-Seq_HELA_Human0.93600136
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92582895
92NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92582895
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92297457
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91369115
95IRF8_22096565_ChIP-ChIP_GC-B_Human0.91257091
96ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90088239
97P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89950320
98IRF8_27001747_Chip-Seq_BMDM_Mouse0.89141561
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.88530598
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87703317
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86995301
102MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86229854
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85737614
104CJUN_26792858_Chip-Seq_BT549_Human0.85342439
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85296672
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84918156
107SA1_27219007_Chip-Seq_ERYTHROID_Human0.84857080
108SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84333474
109SMC4_20622854_ChIP-Seq_HELA_Human0.83530590
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82437037
111CTCF_27219007_Chip-Seq_Bcells_Human0.82352890
112SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81855110
113RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81461423
114* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.81433913
115TP53_20018659_ChIP-ChIP_R1E_Mouse0.81131831
116TP63_22573176_ChIP-Seq_HFKS_Human0.80958248
117TP53_22127205_ChIP-Seq_IMR90_Human0.80703712
118* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.79839043
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79221787
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.78556041
121BRD4_27068464_Chip-Seq_AML-cells_Mouse0.78401118
122CREB1_26743006_Chip-Seq_LNCaP_Human0.78078205
123IRF8_21731497_ChIP-ChIP_J774_Mouse0.77729955
124P68_20966046_ChIP-Seq_HELA_Human0.77224373
125GATA1_19941826_ChIP-Seq_K562_Human0.77057153
126SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.77048523
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76547136
128BCOR_27268052_Chip-Seq_Bcells_Human0.76199784
129SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76198828
130HNF4A_19822575_ChIP-Seq_HepG2_Human0.76157410
131SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.74502260
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.74394562
133CTCF_27219007_Chip-Seq_ERYTHROID_Human0.73846155
134BCL6_27268052_Chip-Seq_Bcells_Human0.73771661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.60531018
2MP0005360_urolithiasis4.26952872
3MP0009840_abnormal_foam_cell3.88372362
4MP0008438_abnormal_cutaneous_collagen3.79970897
5MP0003705_abnormal_hypodermis_morpholog3.45056593
6MP0005365_abnormal_bile_salt3.40841457
7MP0005085_abnormal_gallbladder_physiolo3.27216355
8MP0008875_abnormal_xenobiotic_pharmacok2.79603478
9MP0005083_abnormal_biliary_tract2.61430362
10MP0005058_abnormal_lysosome_morphology2.57454358
11MP0010329_abnormal_lipoprotein_level2.53063561
12MP0003191_abnormal_cellular_cholesterol2.52882821
13MP0003195_calcinosis2.38418863
14MP0003252_abnormal_bile_duct2.30668417
15MP0000604_amyloidosis2.24795836
16MP0005332_abnormal_amino_acid2.07190335
17MP0004858_abnormal_nervous_system2.03823223
18MP0003329_amyloid_beta_deposits2.03621745
19MP0002877_abnormal_melanocyte_morpholog2.03053234
20MP0003279_aneurysm2.02410023
21MP0006054_spinal_hemorrhage1.98254704
22MP0005275_abnormal_skin_tensile1.93599098
23MP0003806_abnormal_nucleotide_metabolis1.90439169
24MP0003172_abnormal_lysosome_physiology1.89392995
25MP0002254_reproductive_system_inflammat1.87996622
26MP0005670_abnormal_white_adipose1.72710787
27MP0005451_abnormal_body_composition1.64090086
28MP0002118_abnormal_lipid_homeostasis1.61171265
29MP0005508_abnormal_skeleton_morphology1.58307956
30MP0004233_abnormal_muscle_weight1.57146446
31MP0005409_darkened_coat_color1.56821441
32MP0000609_abnormal_liver_physiology1.55990661
33MP0001958_emphysema1.53765915
34MP0005319_abnormal_enzyme/_coenzyme1.50162626
35MP0003690_abnormal_glial_cell1.49533378
36MP0003075_altered_response_to1.46555252
37MP0004019_abnormal_vitamin_homeostasis1.45873568
38MP0000751_myopathy1.45786137
39MP0001666_abnormal_nutrient_absorption1.42360132
40MP0004130_abnormal_muscle_cell1.41788696
41MP0003566_abnormal_cell_adhesion1.39879671
42MP0005503_abnormal_tendon_morphology1.37250296
43MP0009384_cardiac_valve_regurgitation1.37099623
44MP0005584_abnormal_enzyme/coenzyme_acti1.35820135
45MP0000534_abnormal_ureter_morphology1.31608953
46MP0009780_abnormal_chondrocyte_physiolo1.23609291
47MP0003300_gastrointestinal_ulcer1.23515087
48MP0003303_peritoneal_inflammation1.23256428
49MP0003436_decreased_susceptibility_to1.23170152
50MP0002089_abnormal_postnatal_growth/wei1.22393631
51MP0003656_abnormal_erythrocyte_physiolo1.22057234
52MP0005076_abnormal_cell_differentiation1.21503885
53MP0005623_abnormal_meninges_morphology1.19273842
54MP0001348_abnormal_lacrimal_gland1.18799773
55MP0003634_abnormal_glial_cell1.17394753
56MP0004272_abnormal_basement_membrane1.16469026
57MP0000920_abnormal_myelination1.15193225
58MP0003950_abnormal_plasma_membrane1.09473147
59MP0009643_abnormal_urine_homeostasis1.08002652
60MP0005023_abnormal_wound_healing1.07906524
61MP0002295_abnormal_pulmonary_circulatio1.07313828
62MP0005167_abnormal_blood-brain_barrier1.04702610
63MP0010386_abnormal_urinary_bladder1.04529535
64MP0002837_dystrophic_cardiac_calcinosis1.03556522
65MP0001915_intracranial_hemorrhage1.01727188
66MP0001533_abnormal_skeleton_physiology1.01387590
67MP0009764_decreased_sensitivity_to1.01292868
68MP0005197_abnormal_uvea_morphology1.00966697
69MP0005666_abnormal_adipose_tissue0.99038162
70MP0003453_abnormal_keratinocyte_physiol0.98301250
71MP0003448_altered_tumor_morphology0.98016825
72MP0002168_other_aberrant_phenotype0.97102559
73MP0000343_altered_response_to0.96862159
74MP0010368_abnormal_lymphatic_system0.96636393
75MP0004510_myositis0.93293705
76MP0003091_abnormal_cell_migration0.92918148
77MP0003011_delayed_dark_adaptation0.92266235
78MP0003045_fibrosis0.90958600
79MP0005166_decreased_susceptibility_to0.90034462
80MP0000858_altered_metastatic_potential0.89199872
81MP0000747_muscle_weakness0.88796447
82MP0002933_joint_inflammation0.88588481
83MP0001299_abnormal_eye_distance/0.88254792
84MP0002269_muscular_atrophy0.86085233
85MP0002971_abnormal_brown_adipose0.86035150
86MP0002998_abnormal_bone_remodeling0.85796160
87MP0002090_abnormal_vision0.85644946
88MP0003942_abnormal_urinary_system0.84463257
89MP0000598_abnormal_liver_morphology0.83310017
90MP0000750_abnormal_muscle_regeneration0.83230734
91MP0003186_abnormal_redox_activity0.83153741
92MP0003879_abnormal_hair_cell0.81362163
93MP0006082_CNS_inflammation0.80790514
94MP0000733_abnormal_muscle_development0.80737322
95MP0008469_abnormal_protein_level0.80130145
96MP0005165_increased_susceptibility_to0.79883197
97MP0004087_abnormal_muscle_fiber0.79427429
98MP0002113_abnormal_skeleton_development0.79308021
99MP0001614_abnormal_blood_vessel0.79254541
100MP0001879_abnormal_lymphatic_vessel0.77847070
101MP0004883_abnormal_blood_vessel0.77795339
102MP0000163_abnormal_cartilage_morphology0.77492200
103MP0000767_abnormal_smooth_muscle0.77215670
104MP0005164_abnormal_response_to0.76601919
105MP0005464_abnormal_platelet_physiology0.76295777
106MP0001756_abnormal_urination0.75770994
107MP0003795_abnormal_bone_structure0.75344460
108MP0005171_absent_coat_pigmentation0.75048370
109MP0008961_abnormal_basal_metabolism0.74338201
110MP0002138_abnormal_hepatobiliary_system0.74014455
111MP0000749_muscle_degeneration0.73999097
112MP0005257_abnormal_intraocular_pressure0.73785761
113MP0001243_abnormal_dermal_layer0.72316903
114MP0001542_abnormal_bone_strength0.71735380
115MP0000249_abnormal_blood_vessel0.71534753
116MP0009763_increased_sensitivity_to0.70794868
117MP0002060_abnormal_skin_morphology0.70520260
118MP0002115_abnormal_skeleton_extremities0.69821129
119MP0005375_adipose_tissue_phenotype0.69483466
120MP0004084_abnormal_cardiac_muscle0.69323521
121MP0009250_abnormal_appendicular_skeleto0.69062533
122MP0009278_abnormal_bone_marrow0.67377834
123MP0005595_abnormal_vascular_smooth0.66782587
124MP0009115_abnormal_fat_cell0.66268867
125MP0000003_abnormal_adipose_tissue0.65550300
126MP0004859_abnormal_synaptic_plasticity0.64776576
127MP0000759_abnormal_skeletal_muscle0.64473164
128MP0002136_abnormal_kidney_physiology0.63634706
129MP0002909_abnormal_adrenal_gland0.62686461
130MP0002108_abnormal_muscle_morphology0.62508539
131MP0005330_cardiomyopathy0.62306750
132MP0002128_abnormal_blood_circulation0.61798494
133MP0008004_abnormal_stomach_pH0.61724660
134MP0005334_abnormal_fat_pad0.61712779
135MP0006138_congestive_heart_failure0.61658734
136MP0004036_abnormal_muscle_relaxation0.61602160
137MP0009642_abnormal_blood_homeostasis0.60952253
138MP0005390_skeleton_phenotype0.60403631
139MP0002896_abnormal_bone_mineralization0.60154100
140MP0009053_abnormal_anal_canal0.59578880
141MP0005193_abnormal_anterior_eye0.59313908
142MP0008874_decreased_physiological_sensi0.59190654
143MP0000678_abnormal_parathyroid_gland0.58908530
144MP0004947_skin_inflammation0.58592675
145MP0004185_abnormal_adipocyte_glucose0.58529202
146MP0001849_ear_inflammation0.58450173
147MP0001175_abnormal_lung_morphology0.57018750
148MP0008260_abnormal_autophagy0.55971856

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.97539441
2Xanthomatosis (HP:0000991)4.55458745
3Complement deficiency (HP:0004431)4.03592951
4Protrusio acetabuli (HP:0003179)3.88530969
5Hyperlipoproteinemia (HP:0010980)3.68091313
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.61640028
7Hypoalphalipoproteinemia (HP:0003233)3.49345461
8Systemic lupus erythematosus (HP:0002725)3.48033977
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.44654128
10Myocardial infarction (HP:0001658)3.44486541
11Premature rupture of membranes (HP:0001788)3.41372060
12Vascular tortuosity (HP:0004948)3.33304068
13Intrahepatic cholestasis (HP:0001406)3.27859939
14Abnormality of complement system (HP:0005339)3.21619269
15Axonal loss (HP:0003447)3.16242586
16Urinary glycosaminoglycan excretion (HP:0003541)3.13407610
17Mucopolysacchariduria (HP:0008155)3.13407610
18Soft skin (HP:0000977)3.13043427
19Dysostosis multiplex (HP:0000943)3.09324435
20Arterial tortuosity (HP:0005116)3.06103977
21Abnormality of glutamine family amino acid metabolism (HP:0010902)2.98892801
22Atrophic scars (HP:0001075)2.96808734
23Bladder diverticulum (HP:0000015)2.96218974
24Prolonged partial thromboplastin time (HP:0003645)2.94419486
25Abnormality of mucopolysaccharide metabolism (HP:0011020)2.94084508
26Abnormality of polysaccharide metabolism (HP:0011012)2.94084508
27Abnormality of glycosaminoglycan metabolism (HP:0004371)2.94084508
28Hyperammonemia (HP:0001987)2.82940889
29Spinal rigidity (HP:0003306)2.79399076
30Asymmetric septal hypertrophy (HP:0001670)2.77563088
31Peritonitis (HP:0002586)2.75975711
32Abnormality of the Achilles tendon (HP:0005109)2.75897953
33Wormian bones (HP:0002645)2.75806092
34Increased cerebral lipofuscin (HP:0011813)2.72614186
35Hypolipoproteinemia (HP:0010981)2.72440762
36Nuclear cataract (HP:0100018)2.69873641
37Cerebral aneurysm (HP:0004944)2.68571611
38Broad metatarsal (HP:0001783)2.66783136
39Joint hemorrhage (HP:0005261)2.64333026
40Abnormality of dentin (HP:0010299)2.61720880
41Fragile skin (HP:0001030)2.60167423
42Blue sclerae (HP:0000592)2.59691669
43Spondylolisthesis (HP:0003302)2.59012248
44Abnormality of the common coagulation pathway (HP:0010990)2.58565400
45Glomerulonephritis (HP:0000099)2.58448326
46Ketosis (HP:0001946)2.57669221
47Neonatal short-limb short stature (HP:0008921)2.57098128
48Follicular hyperkeratosis (HP:0007502)2.53138454
49Skin nodule (HP:0200036)2.51227459
50Genu recurvatum (HP:0002816)2.47399862
51Achilles tendon contracture (HP:0001771)2.45547614
52Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.45099302
53Abnormality of sulfur amino acid metabolism (HP:0004339)2.44521781
54Hypercholesterolemia (HP:0003124)2.44500126
55Cardiovascular calcification (HP:0011915)2.43292297
56Cervical subluxation (HP:0003308)2.42705170
57Amyloidosis (HP:0011034)2.40390370
58Abnormality of proline metabolism (HP:0010907)2.39304160
59Hydroxyprolinuria (HP:0003080)2.39304160
60Upper limb amyotrophy (HP:0009129)2.38606911
61Distal upper limb amyotrophy (HP:0007149)2.38606911
62Epidermoid cyst (HP:0200040)2.35992311
63Neurofibrillary tangles (HP:0002185)2.34819510
64Hyperextensible skin (HP:0000974)2.34690978
65Vascular calcification (HP:0004934)2.33686762
66Abnormal gallbladder physiology (HP:0012438)2.32603760
67Cholecystitis (HP:0001082)2.32603760
68Hyperglycinuria (HP:0003108)2.32168428
69Mitral stenosis (HP:0001718)2.31371827
70Loss of speech (HP:0002371)2.30508430
71Nephritis (HP:0000123)2.27838852
72Joint stiffness (HP:0001387)2.26107323
73Obstructive sleep apnea (HP:0002870)2.24877268
74Hypobetalipoproteinemia (HP:0003563)2.23821474
75Vertebral compression fractures (HP:0002953)2.21723718
76Slender build (HP:0001533)2.20937811
77Abnormality of glycolipid metabolism (HP:0010969)2.20932190
78Abnormality of liposaccharide metabolism (HP:0010968)2.20932190
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.20932190
80Turricephaly (HP:0000262)2.19774009
81Cerebral inclusion bodies (HP:0100314)2.18927644
82Mitral regurgitation (HP:0001653)2.18386642
83Increased connective tissue (HP:0009025)2.18126285
84Hyperacusis (HP:0010780)2.17796137
85Joint laxity (HP:0001388)2.17684704
86Ovoid vertebral bodies (HP:0003300)2.16560231
87Dilatation of the ascending aorta (HP:0005111)2.15844891
88Ankle contracture (HP:0006466)2.15369826
89Abnormality of the intrinsic pathway (HP:0010989)2.13640348
90Increased variability in muscle fiber diameter (HP:0003557)2.12403714
91Vacuolated lymphocytes (HP:0001922)2.12004830
92Abnormality of glycine metabolism (HP:0010895)2.11689263
93Abnormality of serine family amino acid metabolism (HP:0010894)2.11689263
94Global brain atrophy (HP:0002283)2.10078089
95Increased neuronal autofluorescent lipopigment (HP:0002074)2.08935570
96Hand muscle atrophy (HP:0009130)2.07073147
97Osteolytic defects of the hand bones (HP:0009699)2.05854830
98Osteolytic defects of the phalanges of the hand (HP:0009771)2.05854830
99Protuberant abdomen (HP:0001538)2.05385291
100Recurrent gram-negative bacterial infections (HP:0005420)2.05336068
101Abnormality of the acetabulum (HP:0003170)2.03145350
102Shallow orbits (HP:0000586)2.02812288
103Hyporeflexia of lower limbs (HP:0002600)2.02760095
104Natal tooth (HP:0000695)2.02013625
105Aortic aneurysm (HP:0004942)2.01806282
106Abnormality of methionine metabolism (HP:0010901)1.99904057
107Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99758402
108Aortic dissection (HP:0002647)1.98452553
109Ectopia lentis (HP:0001083)1.97896435
110Hyperglycinemia (HP:0002154)1.97891784
111Cholelithiasis (HP:0001081)1.97866433
112Disproportionate tall stature (HP:0001519)1.97547154
113Sensorimotor neuropathy (HP:0007141)1.96472677
114Neonatal onset (HP:0003623)1.96435370
115Biconcave vertebral bodies (HP:0004586)1.95404329
116Ketoacidosis (HP:0001993)1.95392903
117Supranuclear gaze palsy (HP:0000605)1.93956325
118Esophageal varix (HP:0002040)1.92867023
119Mitral valve prolapse (HP:0001634)1.92828786
120Aneurysm (HP:0002617)1.91930196
121Hemorrhage of the eye (HP:0011885)1.90561459
122Aortic valve stenosis (HP:0001650)1.89523665
123Short nail (HP:0001799)1.89379904
124Abnormality of the lumbar spine (HP:0100712)1.88705366
125Elbow flexion contracture (HP:0002987)1.87819474
126Type 1 muscle fiber predominance (HP:0003803)1.86191441
127Bowel diverticulosis (HP:0005222)1.84899544
128Abnormality of fatty-acid metabolism (HP:0004359)1.84665011
129Tetraparesis (HP:0002273)1.84573595
130Thin bony cortex (HP:0002753)1.84069420
131Beaking of vertebral bodies (HP:0004568)1.83695865
132Abnormal gallbladder morphology (HP:0012437)1.82465876
133J-shaped sella turcica (HP:0002680)1.81474729
134Broad face (HP:0000283)1.80891056
135Back pain (HP:0003418)1.80316559
136Status epilepticus (HP:0002133)1.79804510
137Renovascular hypertension (HP:0100817)1.77139225
138Ulnar bowing (HP:0003031)1.76728130
139Mildly elevated creatine phosphokinase (HP:0008180)1.76347090
140Flared iliac wings (HP:0002869)1.75545525
141Overgrowth (HP:0001548)1.74664387
142Insomnia (HP:0100785)1.74636231
143Long toe (HP:0010511)1.73910367
144Coxa vara (HP:0002812)1.73907300
145Polycythemia (HP:0001901)1.73736471
146Hypoventilation (HP:0002791)1.72168746
147Abnormal delivery (HP:0001787)1.71418997
148Aortic regurgitation (HP:0001659)1.71070306
149Apathy (HP:0000741)1.70709403
150Abnormality of skeletal muscle fiber size (HP:0012084)1.70325338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.67214926
2ERN14.44815548
3CDK123.29214758
4SIK12.99140609
5PKN22.92413558
6BCKDK2.51121513
7TTN2.17666776
8FGFR42.05926436
9EPHB12.03877691
10RIPK11.84366982
11PRPF4B1.79374217
12LATS21.76666229
13LMTK21.73224689
14BMX1.72648492
15DDR21.70450748
16CDC42BPA1.68204197
17KSR21.62429746
18TGFBR21.52357505
19PTK61.51643684
20LIMK11.47351108
21NTRK11.37640787
22PDGFRA1.29149778
23PTK2B1.27037795
24TBK11.25552787
25PAK61.21860761
26PTK21.18529808
27CAMK1D1.17814164
28AKT31.10391168
29ICK1.09815992
30PRKD21.09029616
31CAMKK11.08961288
32STK381.08528742
33FER1.07397641
34RET1.05653992
35MAP3K91.04626914
36BLK1.04274793
37LRRK21.02557701
38DAPK21.02327637
39SMG11.02279818
40TYK21.01863189
41JAK11.01756252
42PDGFRB1.01565854
43CAMK1G1.01383063
44ARAF1.01257645
45PHKG11.00323827
46PHKG21.00323827
47TAOK10.99874161
48TYRO30.99398666
49NME20.99243511
50MST1R0.98677940
51MAP3K110.98412051
52EPHA30.98312417
53MAP2K10.97213454
54WNK10.96630106
55SCYL20.93882814
56MAPKAPK30.93502219
57PIM20.89945117
58NEK60.88342078
59ABL20.88218623
60GRK70.87937440
61MAP3K100.87128017
62PDPK10.87101879
63PRKD30.85751591
64PDK30.84111203
65PDK40.84111203
66MAP3K70.81740378
67PAK20.80587674
68MAP2K30.79642742
69NEK90.77611753
70MARK20.77314394
71PAK30.77219749
72JAK20.76987268
73PAK40.76703726
74DMPK0.76505796
75ERBB40.76437232
76MAP2K40.76221806
77MAPK120.75723274
78MAP3K10.72191063
79DAPK30.71273707
80BRD40.70905243
81PIK3CG0.69258051
82MTOR0.68071971
83EEF2K0.65825701
84MOS0.65744206
85MAP3K130.65041961
86EPHB20.64522258
87MAP3K30.64179178
88RIPK40.63882709
89MET0.63251535
90MAPK70.62939029
91ROCK20.62252759
92PDK20.58458495
93PDK10.57450538
94MAP2K20.56216171
95PRKD10.55600301
96TESK10.55028976
97PRKCH0.54073316
98KDR0.53461215
99HIPK20.53250679
100TRPM70.51903621
101MAP3K20.51066051
102HCK0.49040178
103RPS6KC10.48879346
104RPS6KL10.48879346
105MARK10.47669400
106MYLK0.46112462
107MINK10.45318483
108EPHA20.43840725
109MATK0.43549141
110TAOK20.42839018
111PRKCZ0.42418844
112DYRK1B0.41509004
113SRC0.40859681
114MAP3K60.40687187
115CSF1R0.40679936
116RPS6KA20.40655325
117PRKG20.39989712
118ROCK10.39151943
119KIT0.38845891
120CDK150.38298024
121SIK20.38160143
122CAMK2G0.37244094
123PRKACG0.37061549
124GSK3A0.36732241
125NTRK30.36497966
126CDK90.36450470
127IRAK30.35579572
128CDK11A0.35490678
129MAPK40.35258879
130SGK30.33897750
131LATS10.33291590
132CDK180.32495910
133ZAP700.30536891

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.57260805
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.36323630
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.31856550
4Arginine biosynthesis_Homo sapiens_hsa002202.72783707
5Complement and coagulation cascades_Homo sapiens_hsa046102.59448689
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.47934101
7Fatty acid degradation_Homo sapiens_hsa000712.38090133
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18719954
9Staphylococcus aureus infection_Homo sapiens_hsa051502.12234430
10PPAR signaling pathway_Homo sapiens_hsa033202.08164999
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.01091960
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90834580
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90304406
14Tryptophan metabolism_Homo sapiens_hsa003801.89188703
15Fatty acid metabolism_Homo sapiens_hsa012121.88999466
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.74981606
17Propanoate metabolism_Homo sapiens_hsa006401.70988989
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69158870
19Bile secretion_Homo sapiens_hsa049761.62707178
20Caffeine metabolism_Homo sapiens_hsa002321.60555704
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56829446
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.54684410
23Peroxisome_Homo sapiens_hsa041461.35395418
24Lysosome_Homo sapiens_hsa041421.32948922
25Pyruvate metabolism_Homo sapiens_hsa006201.32305796
26Butanoate metabolism_Homo sapiens_hsa006501.31635725
27Starch and sucrose metabolism_Homo sapiens_hsa005001.30501059
28Vibrio cholerae infection_Homo sapiens_hsa051101.29880070
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27490895
30Chemical carcinogenesis_Homo sapiens_hsa052041.25085620
31beta-Alanine metabolism_Homo sapiens_hsa004101.24624555
32Carbon metabolism_Homo sapiens_hsa012001.20372956
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15048252
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13866362
35Biosynthesis of amino acids_Homo sapiens_hsa012301.12623825
36Phenylalanine metabolism_Homo sapiens_hsa003601.10657451
37Histidine metabolism_Homo sapiens_hsa003401.09001009
38Notch signaling pathway_Homo sapiens_hsa043301.06170672
39Adherens junction_Homo sapiens_hsa045201.01127355
40Fatty acid biosynthesis_Homo sapiens_hsa000611.00707327
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.00037048
42Fat digestion and absorption_Homo sapiens_hsa049750.99935880
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98439806
44Estrogen signaling pathway_Homo sapiens_hsa049150.98367131
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.97636099
46VEGF signaling pathway_Homo sapiens_hsa043700.95251691
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95077256
48Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94952603
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94712986
50Renal cell carcinoma_Homo sapiens_hsa052110.94515094
51Chronic myeloid leukemia_Homo sapiens_hsa052200.94029610
52Synaptic vesicle cycle_Homo sapiens_hsa047210.93104165
53Other glycan degradation_Homo sapiens_hsa005110.91677079
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91184552
55Glycerolipid metabolism_Homo sapiens_hsa005610.90955744
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.90014011
57TNF signaling pathway_Homo sapiens_hsa046680.89178913
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87728431
59Salmonella infection_Homo sapiens_hsa051320.87266214
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.85641428
61Sphingolipid metabolism_Homo sapiens_hsa006000.85059859
62Prion diseases_Homo sapiens_hsa050200.84241993
63ABC transporters_Homo sapiens_hsa020100.83417340
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83369748
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83001752
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.82794770
67Tyrosine metabolism_Homo sapiens_hsa003500.82527764
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.81944962
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.81531431
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81351531
71GnRH signaling pathway_Homo sapiens_hsa049120.80602823
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80125014
73Retinol metabolism_Homo sapiens_hsa008300.80078341
74Toxoplasmosis_Homo sapiens_hsa051450.78226237
75Acute myeloid leukemia_Homo sapiens_hsa052210.78040703
76Prolactin signaling pathway_Homo sapiens_hsa049170.76614393
77Endocytosis_Homo sapiens_hsa041440.75650514
78Arginine and proline metabolism_Homo sapiens_hsa003300.73835804
79Selenocompound metabolism_Homo sapiens_hsa004500.73188362
80Glioma_Homo sapiens_hsa052140.72692732
81Rheumatoid arthritis_Homo sapiens_hsa053230.71914522
82MicroRNAs in cancer_Homo sapiens_hsa052060.70613219
83Lysine degradation_Homo sapiens_hsa003100.70026805
84Sulfur relay system_Homo sapiens_hsa041220.69490682
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69030777
86Amoebiasis_Homo sapiens_hsa051460.68132277
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.67051209
88Thyroid hormone synthesis_Homo sapiens_hsa049180.66949729
89ECM-receptor interaction_Homo sapiens_hsa045120.66677824
90Pancreatic cancer_Homo sapiens_hsa052120.66593655
91Cocaine addiction_Homo sapiens_hsa050300.66168753
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65755585
93Fatty acid elongation_Homo sapiens_hsa000620.65542610
94mTOR signaling pathway_Homo sapiens_hsa041500.65229313
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65104494
96Insulin resistance_Homo sapiens_hsa049310.64673736
97Type II diabetes mellitus_Homo sapiens_hsa049300.64332269
98Melanogenesis_Homo sapiens_hsa049160.63359101
99ErbB signaling pathway_Homo sapiens_hsa040120.63320779
100Vitamin digestion and absorption_Homo sapiens_hsa049770.62944292
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62367563
102Gap junction_Homo sapiens_hsa045400.62281484
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61514527
104Rap1 signaling pathway_Homo sapiens_hsa040150.61402481
105Axon guidance_Homo sapiens_hsa043600.60453707
106Steroid biosynthesis_Homo sapiens_hsa001000.59863818
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59715620
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59710858
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59253712
110Renin-angiotensin system_Homo sapiens_hsa046140.59095850
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57265445
112Hepatitis C_Homo sapiens_hsa051600.57232783
113Small cell lung cancer_Homo sapiens_hsa052220.55813311
114Pentose phosphate pathway_Homo sapiens_hsa000300.55339033
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.54079383
116Prostate cancer_Homo sapiens_hsa052150.54001347
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53801523
118Endometrial cancer_Homo sapiens_hsa052130.53765541
119HIF-1 signaling pathway_Homo sapiens_hsa040660.52792018
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52425970
121Shigellosis_Homo sapiens_hsa051310.52097363
122Long-term potentiation_Homo sapiens_hsa047200.50957276
123Galactose metabolism_Homo sapiens_hsa000520.50875281
124Choline metabolism in cancer_Homo sapiens_hsa052310.49859476
125Thyroid cancer_Homo sapiens_hsa052160.49707589
126Gastric acid secretion_Homo sapiens_hsa049710.49238773
127Malaria_Homo sapiens_hsa051440.48937441
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48417044
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48384631
130Melanoma_Homo sapiens_hsa052180.47965366
131Fructose and mannose metabolism_Homo sapiens_hsa000510.47794927
132Ovarian steroidogenesis_Homo sapiens_hsa049130.47783478
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46214546
134GABAergic synapse_Homo sapiens_hsa047270.46178878
135Renin secretion_Homo sapiens_hsa049240.45969723
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45744334
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.44195087
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43620678
139Protein digestion and absorption_Homo sapiens_hsa049740.43273542
140Focal adhesion_Homo sapiens_hsa045100.39191549
141Folate biosynthesis_Homo sapiens_hsa007900.38598841
142Proteoglycans in cancer_Homo sapiens_hsa052050.38451009
143Sulfur metabolism_Homo sapiens_hsa009200.38280514
144Dilated cardiomyopathy_Homo sapiens_hsa054140.36297223
145Phagosome_Homo sapiens_hsa041450.35676272
146Bladder cancer_Homo sapiens_hsa052190.35023216
147Glucagon signaling pathway_Homo sapiens_hsa049220.32930519
148Tuberculosis_Homo sapiens_hsa051520.32262435
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32260794
150Insulin signaling pathway_Homo sapiens_hsa049100.31412007
151AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29377473
152Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29097014
153Osteoclast differentiation_Homo sapiens_hsa043800.28371248
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27316562
155Pertussis_Homo sapiens_hsa051330.27014755
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.25927823
157Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25758203
158Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25133674
159Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24989797
160Glutathione metabolism_Homo sapiens_hsa004800.24932982
161AMPK signaling pathway_Homo sapiens_hsa041520.24335104
162Leishmaniasis_Homo sapiens_hsa051400.23808884
163Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23712077
164Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23312872
165Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23107739

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