PLAUR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.28852367
2regulation of vitamin D biosynthetic process (GO:0060556)5.68140907
3positive regulation by symbiont of host defense response (GO:0052509)5.35737070
4modulation by symbiont of host defense response (GO:0052031)5.35737070
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.35737070
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.35737070
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.35737070
8modulation by symbiont of host immune response (GO:0052553)5.35737070
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.19874771
10response to peptidoglycan (GO:0032494)4.98975472
11respiratory burst (GO:0045730)4.68909667
12granulocyte activation (GO:0036230)4.59171740
13regulation of vitamin metabolic process (GO:0030656)4.47529028
14macrophage activation involved in immune response (GO:0002281)4.36924871
15neutrophil activation (GO:0042119)4.34982398
16wound healing, spreading of epidermal cells (GO:0035313)4.33861110
17superoxide anion generation (GO:0042554)4.30434109
18hydrogen peroxide biosynthetic process (GO:0050665)4.26361581
19positive regulation of chemokine biosynthetic process (GO:0045080)4.23509972
20positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.13607381
21leukocyte aggregation (GO:0070486)4.07688917
22regulation of cytokine secretion involved in immune response (GO:0002739)4.00218252
23lipopolysaccharide-mediated signaling pathway (GO:0031663)3.94929637
24production of molecular mediator involved in inflammatory response (GO:0002532)3.91810228
25reactive oxygen species biosynthetic process (GO:1903409)3.83094567
26regulation of interferon-beta biosynthetic process (GO:0045357)3.80866008
27immunoglobulin mediated immune response (GO:0016064)3.78337994
28response to muramyl dipeptide (GO:0032495)3.73337694
29positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.70323381
30regulation of chronic inflammatory response (GO:0002676)3.69687023
31positive regulation of interferon-alpha production (GO:0032727)3.69196895
32regulation of mast cell degranulation (GO:0043304)3.68764529
33regulation of membrane protein ectodomain proteolysis (GO:0051043)3.66162621
34negative regulation of nitric oxide biosynthetic process (GO:0045019)3.65090444
35glycosphingolipid catabolic process (GO:0046479)3.62466366
36positive regulation of mast cell degranulation (GO:0043306)3.59489634
37positive regulation of mast cell activation involved in immune response (GO:0033008)3.59489634
38response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.58570420
39response to host immune response (GO:0052572)3.58570420
40NIK/NF-kappaB signaling (GO:0038061)3.55345052
41positive regulation of monocyte chemotaxis (GO:0090026)3.55305372
42T-helper 1 type immune response (GO:0042088)3.54294245
43cellular extravasation (GO:0045123)3.54128931
44positive regulation of mast cell activation (GO:0033005)3.53436281
45regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.51690300
46regulation of interferon-alpha production (GO:0032647)3.51558238
47myeloid cell activation involved in immune response (GO:0002275)3.49838193
48negative regulation of mast cell activation (GO:0033004)3.49717904
49positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.48635206
50regulation of mast cell activation involved in immune response (GO:0033006)3.47871021
51oligosaccharide catabolic process (GO:0009313)3.46542064
52negative regulation of cytokine production involved in immune response (GO:0002719)3.44291639
53positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.38953729
54positive regulation of heat generation (GO:0031652)3.38674939
55regulation of chemokine biosynthetic process (GO:0045073)3.38629609
56regulation of mast cell activation (GO:0033003)3.35827669
57regulation of mononuclear cell migration (GO:0071675)3.35323697
58positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.30664836
59macrophage activation (GO:0042116)3.28479560
60response to protozoan (GO:0001562)3.28441201
61regulation of fever generation (GO:0031620)3.27133448
62germinal center formation (GO:0002467)3.26558910
63positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.26390743
64regulation of dendritic cell antigen processing and presentation (GO:0002604)3.25031466
65negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.24196188
66glycolipid catabolic process (GO:0019377)3.23815761
67type I interferon signaling pathway (GO:0060337)3.23490019
68cellular response to type I interferon (GO:0071357)3.23490019
69regulation of heat generation (GO:0031650)3.23437469
70positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.23271203
71cellular response to lipopolysaccharide (GO:0071222)3.23149565
72wound healing, spreading of cells (GO:0044319)3.22852347
73detection of molecule of bacterial origin (GO:0032490)3.22386466
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.22166621
75response to host (GO:0075136)3.22166621
76response to host defenses (GO:0052200)3.22166621
77cellular response to thyroid hormone stimulus (GO:0097067)3.20496649
78regulation of nitric oxide biosynthetic process (GO:0045428)3.18317305
79response to type I interferon (GO:0034340)3.17983382
80negative regulation of interleukin-12 production (GO:0032695)3.15423246
81defense response to protozoan (GO:0042832)3.15042235
82cellular response to molecule of bacterial origin (GO:0071219)3.14212531
83regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.12949570
84neutrophil chemotaxis (GO:0030593)3.04621697
85branching involved in labyrinthine layer morphogenesis (GO:0060670)3.04501946
86positive regulation of nitric oxide biosynthetic process (GO:0045429)3.03632013
87regulation of leukocyte degranulation (GO:0043300)3.03262912
88regulation of myeloid leukocyte mediated immunity (GO:0002886)3.02905347
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.02712540
90positive regulation of acute inflammatory response (GO:0002675)3.02325432
91positive regulation of gamma-delta T cell activation (GO:0046645)3.02262132
92eosinophil chemotaxis (GO:0048245)3.01616512
93regulation of interleukin-8 biosynthetic process (GO:0045414)3.01062007
94interferon-gamma-mediated signaling pathway (GO:0060333)2.99517708
95negative regulation of lipid storage (GO:0010888)2.98637864
96regulation of monocyte chemotaxis (GO:0090025)2.98401464
97positive regulation of leukocyte degranulation (GO:0043302)2.97497633
98leukocyte cell-cell adhesion (GO:0007159)2.97329023
99positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.96593450
100positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.96193374
101neutrophil migration (GO:1990266)2.95716128
102myeloid dendritic cell differentiation (GO:0043011)2.95013497
103regulation of T-helper 2 cell differentiation (GO:0045628)2.94758750
104microglial cell activation (GO:0001774)2.93479789
105positive regulation of cellular amide metabolic process (GO:0034250)2.93172560
106eosinophil migration (GO:0072677)2.92280538
107regulation of interleukin-12 biosynthetic process (GO:0045075)2.91217336
108negative regulation of myeloid cell apoptotic process (GO:0033033)2.91184466
109positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.90178503
110positive regulation of interferon-beta production (GO:0032728)2.89074594
111monocyte chemotaxis (GO:0002548)2.87739152
112positive regulation of type 2 immune response (GO:0002830)2.87340565
113natural killer cell mediated cytotoxicity (GO:0042267)2.86165333
114natural killer cell mediated immunity (GO:0002228)2.86165333
115phagosome maturation (GO:0090382)2.85458261
116ceramide catabolic process (GO:0046514)2.85262205
117regulation of NF-kappaB import into nucleus (GO:0042345)2.84803888
118myeloid leukocyte activation (GO:0002274)2.84667595
119regulation of heterotypic cell-cell adhesion (GO:0034114)2.84156871
120regulation of B cell receptor signaling pathway (GO:0050855)2.82197247
121regulation of interleukin-6 production (GO:0032675)2.82184358
122regulation of podosome assembly (GO:0071801)2.81829911
123regulation of interleukin-12 production (GO:0032655)2.80726244
124low-density lipoprotein particle clearance (GO:0034383)2.80657777
125positive regulation of interleukin-6 production (GO:0032755)2.80492852
126positive regulation of NF-kappaB import into nucleus (GO:0042346)2.80238512
127positive regulation of chemokine production (GO:0032722)2.79389850
128positive regulation of tumor necrosis factor production (GO:0032760)2.77520326
129decidualization (GO:0046697)2.76962744
130negative regulation of production of molecular mediator of immune response (GO:0002701)2.75359694
131Arp2/3 complex-mediated actin nucleation (GO:0034314)2.74596058
132myeloid dendritic cell activation (GO:0001773)2.74450514
133myeloid cell homeostasis (GO:0002262)2.74092952
134cellular response to biotic stimulus (GO:0071216)2.73084653
135B cell mediated immunity (GO:0019724)2.73051891
136neutrophil mediated immunity (GO:0002446)2.72899762
137negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.72875049
138dendritic cell differentiation (GO:0097028)2.72852654
139amino sugar catabolic process (GO:0046348)2.71909587
140regulation of T-helper 1 cell differentiation (GO:0045625)2.70169130
141regulation of macrophage cytokine production (GO:0010935)2.69994943
142positive regulation of antigen processing and presentation (GO:0002579)2.69766852
143modulation of growth of symbiont involved in interaction with host (GO:0044144)2.68680455
144regulation of growth of symbiont in host (GO:0044126)2.68680455
145negative regulation of growth of symbiont in host (GO:0044130)2.68680455
146negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.68680455
147leukocyte mediated cytotoxicity (GO:0001909)2.68452085
148regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.68196624
149virion attachment to host cell (GO:0019062)2.66127156
150adhesion of symbiont to host cell (GO:0044650)2.66127156
151cell adhesion mediated by integrin (GO:0033627)2.66114453
152lymphocyte chemotaxis (GO:0048247)2.65974368
153regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.65843061
154membrane lipid catabolic process (GO:0046466)2.65781674
155detection of other organism (GO:0098543)2.65509322
156granulocyte chemotaxis (GO:0071621)2.65444270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.33345645
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.03495866
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.92508727
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.82345435
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.79758501
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.79580557
7* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.51150113
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.45701967
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.39479543
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13050946
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08997236
12TP63_17297297_ChIP-ChIP_HaCaT_Human3.01219358
13* EGR1_19374776_ChIP-ChIP_THP-1_Human2.83508502
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.82506408
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.71552373
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65738829
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50881384
18* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.44788467
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.41583906
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39606496
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.37915688
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28572214
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19688937
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13760704
25SPI1_23547873_ChIP-Seq_NB4_Human2.10918857
26* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.02744007
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86173971
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.82447036
29VDR_24763502_ChIP-Seq_THP-1_Human1.80598041
30VDR_24787735_ChIP-Seq_THP-1_Human1.74617302
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71254145
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.71085433
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69224618
34CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.62493366
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61542019
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60810536
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60690968
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59630672
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57751887
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.57234419
41* PU_27001747_Chip-Seq_BMDM_Mouse1.56752862
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55477095
43MYB_26560356_Chip-Seq_TH2_Human1.55024181
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52079589
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52079589
46ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.49244314
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47740923
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.44914676
49RUNX_20019798_ChIP-Seq_JUKART_Human1.44621650
50SPI1_23127762_ChIP-Seq_K562_Human1.42705019
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41713299
52SCL_19346495_ChIP-Seq_HPC-7_Human1.40174704
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40100502
54* ELK3_25401928_ChIP-Seq_HUVEC_Human1.37631162
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36536551
56MAF_26560356_Chip-Seq_TH1_Human1.36133019
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32822551
58CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28309949
59CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27463622
60JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27367038
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27037652
62* LXR_22292898_ChIP-Seq_THP-1_Human1.24017624
63MYB_26560356_Chip-Seq_TH1_Human1.24015812
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23780995
65JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21081534
66VDR_21846776_ChIP-Seq_THP-1_Human1.20611155
67CJUN_26792858_Chip-Seq_BT549_Human1.18978748
68* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18725305
69* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18489091
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.18339711
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16961203
72* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16111895
73* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15038754
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13174285
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11718751
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11432063
77* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10840182
78* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10840182
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10576125
80* SOX2_20726797_ChIP-Seq_SW620_Human1.10405769
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06809598
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.05285572
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02277975
84TFEB_21752829_ChIP-Seq_HELA_Human1.01066118
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00788233
86GATA3_27048872_Chip-Seq_THYMUS_Human0.99968068
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99492573
88GATA3_26560356_Chip-Seq_TH2_Human0.98141874
89GATA1_19941826_ChIP-Seq_K562_Human0.97710505
90GATA1_22025678_ChIP-Seq_K562_Human0.97270170
91* KDM2B_26808549_Chip-Seq_DND41_Human0.95542411
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95315047
93PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95068010
94FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94738904
95GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94713237
96STAT1_20625510_ChIP-Seq_HELA_Human0.94698430
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93748103
98* UTX_26944678_Chip-Seq_JUKART_Human0.93683166
99P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92027402
100* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91431884
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90712400
102MAF_26560356_Chip-Seq_TH2_Human0.89301727
103TCF7_22412390_ChIP-Seq_EML_Mouse0.87666962
104GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86742701
105NOTCH1_21737748_ChIP-Seq_TLL_Human0.85249183
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84700688
107BRD4_25478319_ChIP-Seq_HGPS_Human0.83856071
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82511505
109ATF3_27146783_Chip-Seq_COLON_Human0.81942358
110* UBF1/2_26484160_Chip-Seq_HMECs_Human0.81832389
111RXR_22158963_ChIP-Seq_LIVER_Mouse0.81726439
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81624723
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.81265862
114ELK1_19687146_ChIP-ChIP_HELA_Human0.80909023
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.79726907
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76660216
117GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76397284
118KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76018073
119CLOCK_20551151_ChIP-Seq_293T_Human0.75888759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.50702079
2MP0003303_peritoneal_inflammation3.94266709
3MP0001835_abnormal_antigen_presentation3.73027946
4MP0009785_altered_susceptibility_to3.28406268
5MP0002148_abnormal_hypersensitivity_rea3.28204301
6* MP0002419_abnormal_innate_immunity3.16640744
7MP0005000_abnormal_immune_tolerance2.92590050
8MP0003724_increased_susceptibility_to2.83613832
9MP0001533_abnormal_skeleton_physiology2.70998123
10* MP0005025_abnormal_response_to2.58330025
11MP0006082_CNS_inflammation2.52969890
12* MP0002452_abnormal_antigen_presenting2.38875981
13MP0000343_altered_response_to2.38874361
14MP0004510_myositis2.30591780
15MP0005387_immune_system_phenotype2.23559916
16MP0001790_abnormal_immune_system2.23559916
17* MP0002723_abnormal_immune_serum2.11586475
18MP0002405_respiratory_system_inflammati2.08573783
19MP0003448_altered_tumor_morphology2.07156927
20MP0001800_abnormal_humoral_immune2.02809087
21MP0002933_joint_inflammation1.97093119
22MP0002139_abnormal_hepatobiliary_system1.96061587
23MP0000685_abnormal_immune_system1.94536396
24* MP0001819_abnormal_immune_cell1.94178138
25MP0005464_abnormal_platelet_physiology1.93977288
26* MP0002420_abnormal_adaptive_immunity1.92034975
27MP0005451_abnormal_body_composition1.89426631
28MP0005058_abnormal_lysosome_morphology1.87990330
29MP0009764_decreased_sensitivity_to1.86604086
30MP0010352_gastrointestinal_tract_polyps1.82236779
31MP0003566_abnormal_cell_adhesion1.82083966
32MP0000858_altered_metastatic_potential1.80800888
33MP0003806_abnormal_nucleotide_metabolis1.78922133
34MP0009278_abnormal_bone_marrow1.75855263
35MP0004947_skin_inflammation1.73142197
36MP0002998_abnormal_bone_remodeling1.72604389
37* MP0001845_abnormal_inflammatory_respons1.71848658
38MP0005671_abnormal_response_to1.69533500
39MP0005390_skeleton_phenotype1.69174980
40MP0002332_abnormal_exercise_endurance1.61498784
41MP0003075_altered_response_to1.60897799
42* MP0001853_heart_inflammation1.55350108
43MP0005166_decreased_susceptibility_to1.55087360
44MP0005167_abnormal_blood-brain_barrier1.54663890
45MP0003279_aneurysm1.53755651
46MP0003828_pulmonary_edema1.52231202
47MP0005023_abnormal_wound_healing1.51410920
48MP0010155_abnormal_intestine_physiology1.51194840
49MP0008438_abnormal_cutaneous_collagen1.50835775
50MP0009333_abnormal_splenocyte_physiolog1.48896600
51MP0005164_abnormal_response_to1.48639019
52MP0003656_abnormal_erythrocyte_physiolo1.39020935
53MP0005397_hematopoietic_system_phenotyp1.37232554
54MP0001545_abnormal_hematopoietic_system1.37232554
55MP0003091_abnormal_cell_migration1.35670281
56* MP0008469_abnormal_protein_level1.34949028
57MP0000716_abnormal_immune_system1.30224272
58MP0003300_gastrointestinal_ulcer1.27437815
59MP0003690_abnormal_glial_cell1.27127098
60MP0005076_abnormal_cell_differentiation1.25563335
61MP0003705_abnormal_hypodermis_morpholog1.24809370
62MP0002006_tumorigenesis1.23122596
63MP0002877_abnormal_melanocyte_morpholog1.21819531
64MP0003172_abnormal_lysosome_physiology1.21454762
65MP0004782_abnormal_surfactant_physiolog1.17548955
66MP0003186_abnormal_redox_activity1.16364384
67MP0003191_abnormal_cellular_cholesterol1.16176782
68MP0002398_abnormal_bone_marrow1.15874820
69MP0001851_eye_inflammation1.14687308
70MP0001542_abnormal_bone_strength1.13330674
71MP0003195_calcinosis1.13049818
72MP0005165_increased_susceptibility_to1.11769441
73MP0003795_abnormal_bone_structure1.11345442
74MP0008004_abnormal_stomach_pH1.10435961
75MP0003453_abnormal_keratinocyte_physiol1.09242234
76MP0001958_emphysema1.07086233
77MP0002429_abnormal_blood_cell1.06156298
78MP0000689_abnormal_spleen_morphology1.03032188
79MP0000249_abnormal_blood_vessel0.98802928
80MP0004883_abnormal_blood_vessel0.96427454
81MP0000767_abnormal_smooth_muscle0.95133452
82MP0002722_abnormal_immune_system0.93707985
83MP0000569_abnormal_digit_pigmentation0.91878326
84MP0005310_abnormal_salivary_gland0.91230661
85MP0003950_abnormal_plasma_membrane0.91082949
86MP0000465_gastrointestinal_hemorrhage0.90710949
87MP0000920_abnormal_myelination0.90611345
88MP0009840_abnormal_foam_cell0.88332576
89MP0009765_abnormal_xenobiotic_induced0.88024566
90MP0003329_amyloid_beta_deposits0.85633502
91MP0004808_abnormal_hematopoietic_stem0.84456587
92MP0010307_abnormal_tumor_latency0.82917853
93MP0001879_abnormal_lymphatic_vessel0.78621728
94MP0001663_abnormal_digestive_system0.76141881
95MP0000604_amyloidosis0.75704633
96MP0009763_increased_sensitivity_to0.75400356
97MP0005257_abnormal_intraocular_pressure0.75363334
98MP0002295_abnormal_pulmonary_circulatio0.74440782
99MP0000490_abnormal_crypts_of0.72639039
100MP0006054_spinal_hemorrhage0.72208902
101MP0002254_reproductive_system_inflammat0.71477082
102MP0008874_decreased_physiological_sensi0.70924981
103MP0002113_abnormal_skeleton_development0.70716935
104MP0000750_abnormal_muscle_regeneration0.68810497
105MP0005595_abnormal_vascular_smooth0.65977642
106MP0002138_abnormal_hepatobiliary_system0.65520654
107MP0002136_abnormal_kidney_physiology0.64191164
108MP0001243_abnormal_dermal_layer0.62849618
109MP0000733_abnormal_muscle_development0.62339587
110MP0005174_abnormal_tail_pigmentation0.60324624
111MP0005275_abnormal_skin_tensile0.60314471
112MP0005647_abnormal_sex_gland0.59792235
113MP0001873_stomach_inflammation0.57235845
114MP0008260_abnormal_autophagy0.57151097
115MP0004272_abnormal_basement_membrane0.56453955
116MP0002277_abnormal_respiratory_mucosa0.52035516
117MP0001849_ear_inflammation0.51834400
118MP0002837_dystrophic_cardiac_calcinosis0.51280543
119MP0001216_abnormal_epidermal_layer0.50742434
120MP0005319_abnormal_enzyme/_coenzyme0.50725195

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.89483334
2Recurrent abscess formation (HP:0002722)6.57773907
3Recurrent gram-negative bacterial infections (HP:0005420)5.89203796
4Recurrent bacterial skin infections (HP:0005406)5.80292038
5Abnormality of macrophages (HP:0004311)4.74251268
6Mediastinal lymphadenopathy (HP:0100721)4.53081833
7Loss of speech (HP:0002371)4.46424395
8Stomatitis (HP:0010280)3.99904151
9Epiphyseal dysplasia (HP:0002656)3.91774973
10Gingivitis (HP:0000230)3.76039074
11Obstructive lung disease (HP:0006536)3.66694031
12Chronic obstructive pulmonary disease (HP:0006510)3.66694031
13Mutism (HP:0002300)3.63646625
14Nuclear cataract (HP:0100018)3.57133343
15Abnormality of polysaccharide metabolism (HP:0011012)3.49580721
16Abnormality of glycosaminoglycan metabolism (HP:0004371)3.49580721
17Abnormality of mucopolysaccharide metabolism (HP:0011020)3.49580721
18Recurrent skin infections (HP:0001581)3.48994691
19Neurofibrillary tangles (HP:0002185)3.46961274
20Amyloidosis (HP:0011034)3.32718072
21Urinary glycosaminoglycan excretion (HP:0003541)3.26429508
22Mucopolysacchariduria (HP:0008155)3.26429508
23Irregular epiphyses (HP:0010582)3.23314600
24Recurrent fungal infections (HP:0002841)3.21396486
25Increased cerebral lipofuscin (HP:0011813)3.19732287
26Vacuolated lymphocytes (HP:0001922)3.18129507
27Elevated erythrocyte sedimentation rate (HP:0003565)3.14353565
28Cellulitis (HP:0100658)3.13850020
29Myositis (HP:0100614)3.12839626
30Orchitis (HP:0100796)3.10922928
31Increased neuronal autofluorescent lipopigment (HP:0002074)3.05884060
32Interstitial pulmonary disease (HP:0006530)3.01145116
33Cupped ribs (HP:0000887)2.97891815
34Increased serum ferritin (HP:0003281)2.95034398
35Axonal loss (HP:0003447)2.91311685
36Autoimmune thrombocytopenia (HP:0001973)2.84173513
37Keratoconjunctivitis sicca (HP:0001097)2.83369722
38Small epiphyses (HP:0010585)2.83049307
39Vitreoretinal degeneration (HP:0000655)2.82926527
40Apathy (HP:0000741)2.82394940
41Cervical subluxation (HP:0003308)2.77716335
42Retrobulbar optic neuritis (HP:0100654)2.77075454
43Optic neuritis (HP:0100653)2.77075454
44Diminished motivation (HP:0000745)2.76873788
45Recurrent pneumonia (HP:0006532)2.68215311
46Vertebral compression fractures (HP:0002953)2.63734439
47Flat capital femoral epiphysis (HP:0003370)2.62021954
48Absent frontal sinuses (HP:0002688)2.61671150
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.61587246
50Osteolytic defects of the hand bones (HP:0009699)2.61587246
51Progressive neurologic deterioration (HP:0002344)2.56530833
52Keratoconjunctivitis (HP:0001096)2.56104047
53Abnormality of the vasculature of the conjunctiva (HP:0008054)2.54908152
54Flat acetabular roof (HP:0003180)2.52611365
55Glomerulonephritis (HP:0000099)2.51204712
56Systemic lupus erythematosus (HP:0002725)2.50671840
57Pustule (HP:0200039)2.49076740
58Myocardial infarction (HP:0001658)2.47906216
59Hepatosplenomegaly (HP:0001433)2.45384316
60Neuronal loss in central nervous system (HP:0002529)2.44219351
61Cerebral inclusion bodies (HP:0100314)2.44043197
62Purpura (HP:0000979)2.43974973
63Urticaria (HP:0001025)2.41356410
64Premature rupture of membranes (HP:0001788)2.36971051
65Thick nail (HP:0001805)2.36969256
66Upper motor neuron abnormality (HP:0002127)2.34206156
67Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.30626811
68Abnormal tarsal ossification (HP:0008369)2.30330612
69Gangrene (HP:0100758)2.29311839
70Vasculitis (HP:0002633)2.28996606
71Chronic mucocutaneous candidiasis (HP:0002728)2.27874594
72Recurrent cutaneous fungal infections (HP:0011370)2.27874594
73Recurrent lower respiratory tract infections (HP:0002783)2.27334934
74Osteomyelitis (HP:0002754)2.27133114
75Prolonged neonatal jaundice (HP:0006579)2.26989425
76Increased IgM level (HP:0003496)2.26421490
77Abnormality of iron homeostasis (HP:0011031)2.26372284
78Prostate neoplasm (HP:0100787)2.24753606
79Hypoplastic ischia (HP:0003175)2.24034502
80Disinhibition (HP:0000734)2.23564913
81Nausea (HP:0002018)2.22583506
82Inappropriate behavior (HP:0000719)2.22373558
83Polyneuropathy (HP:0001271)2.21696966
84Abnormal foot bone ossification (HP:0010675)2.20283191
85Beaking of vertebral bodies (HP:0004568)2.19234890
86Abnormality of glycolipid metabolism (HP:0010969)2.18653730
87Abnormality of liposaccharide metabolism (HP:0010968)2.18653730
88Abnormality of glycosphingolipid metabolism (HP:0004343)2.18653730
89Pulmonary infiltrates (HP:0002113)2.18503229
90Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.17468506
91Recurrent viral infections (HP:0004429)2.16994171
92Coxa vara (HP:0002812)2.16625068
93Periodontitis (HP:0000704)2.14616146
94Basal ganglia calcification (HP:0002135)2.13597053
95Thoracolumbar scoliosis (HP:0002944)2.11751233
96Flattened epiphyses (HP:0003071)2.10531324
97Metaphyseal cupping (HP:0003021)2.08339526
98Abnormality of the lumbar spine (HP:0100712)2.06883801
99Peritonitis (HP:0002586)2.05075021
100Meningitis (HP:0001287)2.03639244
101Asymmetric septal hypertrophy (HP:0001670)2.00870541
102Parakeratosis (HP:0001036)2.00726368
103Malnutrition (HP:0004395)2.00464449
104Arthropathy (HP:0003040)1.96734920
105Personality changes (HP:0000751)1.95559122
106Episodic fever (HP:0001954)1.95386336
107Anorexia (HP:0002039)1.93604812
108Tetraparesis (HP:0002273)1.93482487
109Abnormality of the frontal sinuses (HP:0002687)1.93239754
110Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.92716940
111Arthralgia (HP:0002829)1.91406141
112Spondylolisthesis (HP:0003302)1.90334291
113Dysostosis multiplex (HP:0000943)1.88926713
114Dementia (HP:0000726)1.88682303
115Hypergammaglobulinemia (HP:0010702)1.86802673
116Glomerulopathy (HP:0100820)1.86400380
117Absent epiphyses (HP:0010577)1.86127173
118Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86127173
119Abnormality of the ischium (HP:0003174)1.85859453
120Leukocytosis (HP:0001974)1.85533509
121Abnormality of the vertebral endplates (HP:0005106)1.84654578
122Supranuclear gaze palsy (HP:0000605)1.84180630
123Spontaneous hematomas (HP:0007420)1.83741922
124Abnormality of the pericardium (HP:0001697)1.83588734
125Neonatal short-limb short stature (HP:0008921)1.82848051
126Abnormality of the distal phalanges of the toes (HP:0010182)1.82496747
127Platyspondyly (HP:0000926)1.82462268
128Bone pain (HP:0002653)1.82459488
129Petechiae (HP:0000967)1.81666039
130Agnosia (HP:0010524)1.80453290
131Arterial thrombosis (HP:0004420)1.80290486
132Peripheral demyelination (HP:0011096)1.80193102
133Abnormality of transition element cation homeostasis (HP:0011030)1.79502125
134Hematochezia (HP:0002573)1.78749142
135Metaphyseal irregularity (HP:0003025)1.78467341
136Increased CSF protein (HP:0002922)1.78236128
137Poor head control (HP:0002421)1.77902364
138Anhidrosis (HP:0000970)1.77828654
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77374988
140Pathologic fracture (HP:0002756)1.77178601
141T lymphocytopenia (HP:0005403)1.76818462
142Spinal cord lesions (HP:0100561)1.76581534
143Syringomyelia (HP:0003396)1.76581534
144Hemoptysis (HP:0002105)1.76145297
145Cheilitis (HP:0100825)1.75660765
146Abnormality of femoral epiphyses (HP:0006499)1.74756714
147Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.74756714
148Complement deficiency (HP:0004431)1.74522554
149Vertigo (HP:0002321)1.73188697
150Abnormality of the pleura (HP:0002103)1.72330513
151Memory impairment (HP:0002354)1.71199878
152Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.70877730

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.89140864
2BLK3.76990663
3RIPK43.22473047
4IRAK33.10431058
5PBK3.10311362
6TBK13.02317762
7MAP3K32.70179594
8IRAK42.63285617
9PIM22.52482659
10ERN12.35226554
11MAP4K12.23356289
12IKBKB2.18349685
13NME22.05940176
14PRPF4B1.85558603
15IKBKE1.79044660
16MST41.76868673
17MAP2K31.69986772
18MAP3K111.69342383
19TRPM71.68526122
20STK101.67105500
21ABL21.63886657
22BMX1.61918468
23RPS6KA41.56979243
24EPHA21.53880118
25CSK1.53768344
26EPHB11.53511810
27TYK21.50904267
28TXK1.50400895
29PIM11.47879416
30JAK31.44832030
31ERBB31.44498916
32KIT1.41228095
33MST1R1.35892277
34CHUK1.31263320
35TTN1.28743975
36CDC42BPA1.27288242
37TESK11.26192981
38TAOK21.21752601
39MARK31.20063773
40TGFBR21.18372857
41IRAK21.17192501
42HCK1.16603175
43ARAF1.12484597
44TEC1.11975181
45LRRK21.11141914
46PRKG21.11076227
47KDR1.10485871
48ADRBK21.09539476
49ZAP701.07033970
50BTK1.05737946
51JAK11.03255288
52TRIB31.03235195
53ACVR1B1.02653358
54DDR21.01310914
55IRAK10.99685488
56NEK90.99536626
57FGR0.98128715
58TAOK10.97974016
59LYN0.97446737
60CLK10.90827211
61EIF2AK30.88046492
62SYK0.82279810
63MOS0.80315955
64PAK40.76492952
65LATS20.76256314
66MAP3K50.75468526
67LCK0.72634486
68MAP3K120.72291771
69PRKCD0.72118004
70PTK60.71465392
71STK30.71385168
72ABL10.70812245
73MET0.70715415
74EIF2AK20.68756680
75MATK0.68514841
76CSF1R0.65544629
77EGFR0.63697250
78SIK30.63567428
79BMPR20.61043340
80EPHA30.60808218
81PDGFRA0.56246697
82STK40.55440072
83JAK20.54104473
84CAMKK20.53654739
85RIPK10.51718328
86ITK0.51561997
87STK240.51497176
88MAP3K130.51405897
89MAP2K60.50489390
90MAP3K10.48705820
91FES0.48563913
92PKN20.46478292
93MAP3K80.45158447
94MAPK40.43139235
95PIK3CG0.41592391
96ERBB40.41378714
97GRK70.40582096
98MAPKAPK20.39903977
99DAPK20.37768798
100GSK3A0.37405726
101TYRO30.36755209
102CDK60.36738033
103DAPK30.36702595
104MAP3K100.36365520
105TAOK30.36308291
106NLK0.36106268
107LIMK10.35812802
108PTK20.33876197
109RPS6KA60.32990713
110MAPK70.32709971
111PDGFRB0.31982775
112CAMK1D0.31842407
113YES10.31012145
114GRK60.30900888
115PDK20.30787276
116TESK20.30356607
117DYRK30.30241095
118HIPK20.30163917
119INSR0.30147414
120PDPK10.29184928
121RPS6KL10.28317050
122RPS6KC10.28317050
123EPHB20.24901443
124PDK10.24326666
125PAK10.23047232
126SIK10.21733946
127KSR10.21371290
128KSR20.20396073
129BRAF0.19350253

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.49064470
2Legionellosis_Homo sapiens_hsa051342.73027651
3Malaria_Homo sapiens_hsa051442.69411999
4Graft-versus-host disease_Homo sapiens_hsa053322.61446302
5Staphylococcus aureus infection_Homo sapiens_hsa051502.48443935
6Rheumatoid arthritis_Homo sapiens_hsa053232.46706264
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.44702103
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.39897075
9Osteoclast differentiation_Homo sapiens_hsa043802.38738424
10Tuberculosis_Homo sapiens_hsa051522.30053466
11Pertussis_Homo sapiens_hsa051332.24720020
12Phagosome_Homo sapiens_hsa041452.21578302
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.18574398
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09934184
15Salmonella infection_Homo sapiens_hsa051322.04093859
16TNF signaling pathway_Homo sapiens_hsa046681.96483270
17Asthma_Homo sapiens_hsa053101.94070733
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89903357
19Hematopoietic cell lineage_Homo sapiens_hsa046401.87319243
20Lysosome_Homo sapiens_hsa041421.85491417
21Shigellosis_Homo sapiens_hsa051311.74461901
22Allograft rejection_Homo sapiens_hsa053301.62414488
23Measles_Homo sapiens_hsa051621.60368267
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59872291
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57056582
26Other glycan degradation_Homo sapiens_hsa005111.51445006
27Apoptosis_Homo sapiens_hsa042101.50161013
28Influenza A_Homo sapiens_hsa051641.46397662
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46317119
30B cell receptor signaling pathway_Homo sapiens_hsa046621.45020242
31Toxoplasmosis_Homo sapiens_hsa051451.44999549
32Type I diabetes mellitus_Homo sapiens_hsa049401.42783298
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41360163
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.40776441
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38554131
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.36452991
37African trypanosomiasis_Homo sapiens_hsa051431.27279027
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.25747400
39Amoebiasis_Homo sapiens_hsa051461.23133794
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20153822
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19137914
42Chemokine signaling pathway_Homo sapiens_hsa040621.17855697
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15498376
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12981711
45Antigen processing and presentation_Homo sapiens_hsa046121.10588023
46Hepatitis B_Homo sapiens_hsa051611.09514415
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.07713906
48Herpes simplex infection_Homo sapiens_hsa051681.07455282
49Viral myocarditis_Homo sapiens_hsa054161.04712310
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.03107100
51ECM-receptor interaction_Homo sapiens_hsa045120.97977013
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97706148
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88147757
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77914739
55Collecting duct acid secretion_Homo sapiens_hsa049660.77231077
56* Proteoglycans in cancer_Homo sapiens_hsa052050.76427932
57Chronic myeloid leukemia_Homo sapiens_hsa052200.76136044
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75956364
59Acute myeloid leukemia_Homo sapiens_hsa052210.75400801
60Epstein-Barr virus infection_Homo sapiens_hsa051690.74675771
61Hepatitis C_Homo sapiens_hsa051600.74391919
62Platelet activation_Homo sapiens_hsa046110.73348603
63HIF-1 signaling pathway_Homo sapiens_hsa040660.72302881
64Focal adhesion_Homo sapiens_hsa045100.70680885
65Sulfur metabolism_Homo sapiens_hsa009200.69725478
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68912821
67Small cell lung cancer_Homo sapiens_hsa052220.66694041
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.64849816
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64329152
70Vibrio cholerae infection_Homo sapiens_hsa051100.63112476
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62611032
72Galactose metabolism_Homo sapiens_hsa000520.61907499
73T cell receptor signaling pathway_Homo sapiens_hsa046600.61176391
74Sphingolipid metabolism_Homo sapiens_hsa006000.59301515
75Adherens junction_Homo sapiens_hsa045200.56343781
76Viral carcinogenesis_Homo sapiens_hsa052030.55243782
77Autoimmune thyroid disease_Homo sapiens_hsa053200.55240895
78Pancreatic cancer_Homo sapiens_hsa052120.54838362
79MicroRNAs in cancer_Homo sapiens_hsa052060.54346120
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49087090
81TGF-beta signaling pathway_Homo sapiens_hsa043500.48546249
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.48092382
83p53 signaling pathway_Homo sapiens_hsa041150.47347686
84Prion diseases_Homo sapiens_hsa050200.47347038
85Mineral absorption_Homo sapiens_hsa049780.46591919
86* Complement and coagulation cascades_Homo sapiens_hsa046100.46328026
87HTLV-I infection_Homo sapiens_hsa051660.46149233
88Bladder cancer_Homo sapiens_hsa052190.44343197
89VEGF signaling pathway_Homo sapiens_hsa043700.42616863
90Fructose and mannose metabolism_Homo sapiens_hsa000510.42387748
91Proteasome_Homo sapiens_hsa030500.41736473
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38091903
93Primary immunodeficiency_Homo sapiens_hsa053400.37605534
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36383106
95Type II diabetes mellitus_Homo sapiens_hsa049300.34191580
96Renal cell carcinoma_Homo sapiens_hsa052110.33656749
97Endocytosis_Homo sapiens_hsa041440.33615439
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.32211864
99Prolactin signaling pathway_Homo sapiens_hsa049170.30137380
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28327521
101Renin-angiotensin system_Homo sapiens_hsa046140.28047499
102FoxO signaling pathway_Homo sapiens_hsa040680.27537165
103Prostate cancer_Homo sapiens_hsa052150.26042890
104PPAR signaling pathway_Homo sapiens_hsa033200.25649785
105Rap1 signaling pathway_Homo sapiens_hsa040150.25462790
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22831075
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21852162
108Notch signaling pathway_Homo sapiens_hsa043300.20546738
109Insulin resistance_Homo sapiens_hsa049310.18084123
110Pentose phosphate pathway_Homo sapiens_hsa000300.17247764
111MAPK signaling pathway_Homo sapiens_hsa040100.17152799
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14771128
113Glutathione metabolism_Homo sapiens_hsa004800.14148747
114GnRH signaling pathway_Homo sapiens_hsa049120.13701579
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.13561081

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