PLAG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in labyrinthine layer morphogenesis (GO:0060670)5.48727196
2cell proliferation in forebrain (GO:0021846)4.89480966
3somite development (GO:0061053)4.74774535
4anterior/posterior axis specification, embryo (GO:0008595)4.47335592
5sulfation (GO:0051923)4.26436759
6negative regulation of fibroblast apoptotic process (GO:2000270)4.21490144
7histone H3-K36 demethylation (GO:0070544)4.08688630
8mitotic sister chromatid cohesion (GO:0007064)3.99246759
9mitochondrial respiratory chain complex I assembly (GO:0032981)3.98871219
10NADH dehydrogenase complex assembly (GO:0010257)3.98871219
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.98871219
12regulation of mesoderm development (GO:2000380)3.95273251
13lateral sprouting from an epithelium (GO:0060601)3.90548157
14paraxial mesoderm development (GO:0048339)3.83402743
15spindle assembly involved in mitosis (GO:0090307)3.82888396
16synapsis (GO:0007129)3.72349267
17lung-associated mesenchyme development (GO:0060484)3.67614745
18negative regulation of keratinocyte proliferation (GO:0010839)3.63332115
19regulation of tight junction assembly (GO:2000810)3.63032973
20regulation of non-canonical Wnt signaling pathway (GO:2000050)3.50658449
21behavioral response to nicotine (GO:0035095)3.49237566
22epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.45700693
23negative regulation of astrocyte differentiation (GO:0048712)3.45180090
24otic vesicle formation (GO:0030916)3.44965849
25pituitary gland development (GO:0021983)3.43740573
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35362706
27nuclear pore complex assembly (GO:0051292)3.34317099
28metaphase plate congression (GO:0051310)3.32951746
29positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.32100330
30histone lysine demethylation (GO:0070076)3.30820798
31meiotic chromosome segregation (GO:0045132)3.28282868
32monoubiquitinated protein deubiquitination (GO:0035520)3.27718916
33regulation of keratinocyte proliferation (GO:0010837)3.27235095
34regulation of fibroblast apoptotic process (GO:2000269)3.26279410
35endoderm formation (GO:0001706)3.26134398
36DNA deamination (GO:0045006)3.25098585
37regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.24171885
38protein complex biogenesis (GO:0070271)3.18770720
39artery development (GO:0060840)3.18478844
40mitotic metaphase plate congression (GO:0007080)3.18320995
41histone demethylation (GO:0016577)3.17694525
42kinetochore organization (GO:0051383)3.16879079
43regulation of DNA endoreduplication (GO:0032875)3.13388037
44centrosome duplication (GO:0051298)3.11441658
45CENP-A containing nucleosome assembly (GO:0034080)3.10886831
46interkinetic nuclear migration (GO:0022027)3.10607413
47regulation of sequestering of triglyceride (GO:0010889)3.09358574
48positive regulation of oligodendrocyte differentiation (GO:0048714)3.07285033
49spinal cord development (GO:0021510)3.06762328
50dentate gyrus development (GO:0021542)3.06456090
51lymphangiogenesis (GO:0001946)3.06022216
52kinetochore assembly (GO:0051382)3.04105894
53response to caffeine (GO:0031000)3.03101690
54ventricular septum development (GO:0003281)3.01633678
55negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.00647919
56presynaptic membrane assembly (GO:0097105)2.95475076
57radial glial cell differentiation (GO:0060019)2.94889953
58nuclear pore organization (GO:0006999)2.94864115
59negative regulation of Rho protein signal transduction (GO:0035024)2.94603726
60positive regulation of mitochondrial fission (GO:0090141)2.93536841
61regulation of cell proliferation involved in kidney development (GO:1901722)2.93330754
62organ formation (GO:0048645)2.93265023
63negative regulation of transcription regulatory region DNA binding (GO:2000678)2.92306134
64positive regulation of fatty acid oxidation (GO:0046321)2.91440630
65chromatin remodeling at centromere (GO:0031055)2.91323697
66response to lipoprotein particle (GO:0055094)2.90868088
67cytoplasmic mRNA processing body assembly (GO:0033962)2.90088487
68regulation of meiosis I (GO:0060631)2.89976138
69mitochondrial respiratory chain complex assembly (GO:0033108)2.88458883
70protein demethylation (GO:0006482)2.87631076
71protein dealkylation (GO:0008214)2.87631076
72bone trabecula formation (GO:0060346)2.87573067
73peripheral nervous system axon ensheathment (GO:0032292)2.85513099
74myelination in peripheral nervous system (GO:0022011)2.85513099
75type B pancreatic cell development (GO:0003323)2.85412495
76female gonad development (GO:0008585)2.84361159
77regulation of glomerulus development (GO:0090192)2.83240655
78myoblast migration (GO:0051451)2.83074686
79DNA replication-independent nucleosome organization (GO:0034724)2.82135012
80DNA replication-independent nucleosome assembly (GO:0006336)2.82135012
81oocyte maturation (GO:0001556)2.80527590
82microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.79403257
83negative regulation of cardiac muscle tissue development (GO:0055026)2.78836076
84histone H3-K9 methylation (GO:0051567)2.77220996
85somatic stem cell division (GO:0048103)2.76941722
86water-soluble vitamin biosynthetic process (GO:0042364)2.76824207
87regulation of centriole replication (GO:0046599)2.74995974
88cranial suture morphogenesis (GO:0060363)2.74497042
89pharyngeal system development (GO:0060037)2.74132419
90negative regulation of systemic arterial blood pressure (GO:0003085)2.72439595
91limb development (GO:0060173)2.72388174
92appendage development (GO:0048736)2.72388174
93craniofacial suture morphogenesis (GO:0097094)2.72255798
94preassembly of GPI anchor in ER membrane (GO:0016254)2.71628018
95negative regulation of telomerase activity (GO:0051974)2.71602774
96signal transduction involved in regulation of gene expression (GO:0023019)2.70775757
97outer ear morphogenesis (GO:0042473)2.68701875
98protein polyglutamylation (GO:0018095)2.68325417
99histone exchange (GO:0043486)2.67793802
100pore complex assembly (GO:0046931)2.67579756
101mesenchymal-epithelial cell signaling (GO:0060638)2.66964251
102replication fork processing (GO:0031297)2.66827408
103establishment of chromosome localization (GO:0051303)2.66790362
104sister chromatid cohesion (GO:0007062)2.65974313
105regulation of energy homeostasis (GO:2000505)2.65496416
106cellular response to gamma radiation (GO:0071480)2.64894083
107limb bud formation (GO:0060174)2.63908154
108positive regulation of DNA-dependent DNA replication (GO:2000105)2.63899802
109embryonic digit morphogenesis (GO:0042733)2.63225000
110regulation of sister chromatid cohesion (GO:0007063)2.62278676
111regulation of transforming growth factor beta2 production (GO:0032909)2.61922621
112regulation of spindle organization (GO:0090224)2.61461069
113positive regulation of cardiac muscle cell differentiation (GO:2000727)2.60483531
114regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.60314077
115mitotic chromosome condensation (GO:0007076)2.59464819
116response to BMP (GO:0071772)2.59415112
117cellular response to BMP stimulus (GO:0071773)2.59415112
118positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.59027344
119regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.59027344
1203-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.58517149
121purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.58517149
122negative regulation of mast cell activation (GO:0033004)2.57593168
123nephron epithelium morphogenesis (GO:0072088)2.56215823
124nephron tubule morphogenesis (GO:0072078)2.56215823
125regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.55871782
126embryonic hindlimb morphogenesis (GO:0035116)2.55858633
127DNA double-strand break processing (GO:0000729)2.55691300
128presynaptic membrane organization (GO:0097090)2.55532325
129peristalsis (GO:0030432)2.55238658
130protein K6-linked ubiquitination (GO:0085020)2.55225576
131dorsal/ventral axis specification (GO:0009950)2.54993939
132cartilage morphogenesis (GO:0060536)2.54602965
133planar cell polarity pathway involved in neural tube closure (GO:0090179)2.53693952
134regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53178261
135epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53099529
136pre-miRNA processing (GO:0031054)2.52498035
137cardiac septum development (GO:0003279)2.50826713
138regulation of posttranscriptional gene silencing (GO:0060147)2.50542407
139regulation of gene silencing by miRNA (GO:0060964)2.50542407
140regulation of gene silencing by RNA (GO:0060966)2.50542407
141centriole replication (GO:0007099)2.49023535
142positive regulation of potassium ion transmembrane transport (GO:1901381)2.48839727
143positive regulation of glomerulus development (GO:0090193)2.48663416
144male meiosis (GO:0007140)2.47979262
145regulation of hippo signaling (GO:0035330)2.47744958
146retinal ganglion cell axon guidance (GO:0031290)2.47680359
147chromosome organization involved in meiosis (GO:0070192)2.47635868
148mitochondrion morphogenesis (GO:0070584)2.47200764
149serine family amino acid catabolic process (GO:0009071)2.46910939
150regulation of histone H3-K27 methylation (GO:0061085)2.46478466
151maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.45753540
152histone H3-K4 methylation (GO:0051568)2.45597591
153prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.44228813
154spindle checkpoint (GO:0031577)2.44043798
155negative regulation of DNA repair (GO:0045738)2.42176443
156nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.42028292
157notochord development (GO:0030903)2.41942331
158genitalia morphogenesis (GO:0035112)2.41729159
159negative regulation of histone methylation (GO:0031061)2.41096434
160regulation of telomere maintenance via telomerase (GO:0032210)2.40722587
161protein prenylation (GO:0018342)2.40705750
162prenylation (GO:0097354)2.40705750
163magnesium ion transport (GO:0015693)2.40117468
164tongue development (GO:0043586)2.39814930
165regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.39272879
166dorsal/ventral pattern formation (GO:0009953)2.39219782
167chromosome segregation (GO:0007059)2.39177903
168piRNA metabolic process (GO:0034587)2.38722853
169regulation of retinoic acid receptor signaling pathway (GO:0048385)2.38406591
170hindlimb morphogenesis (GO:0035137)2.38249573
171positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.38109319
172regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.38109319
173kidney morphogenesis (GO:0060993)2.38010560
174replicative senescence (GO:0090399)2.37793733
175regulation of collateral sprouting (GO:0048670)2.36352145
176DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.35681478
177DNA replication checkpoint (GO:0000076)2.35604667
178positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.34566490
179DNA strand renaturation (GO:0000733)2.33800127
180glandular epithelial cell development (GO:0002068)2.33026777
181regulation of RNA export from nucleus (GO:0046831)2.32982667
182histone H3-K4 trimethylation (GO:0080182)2.32532414
183negative regulation of DNA-dependent DNA replication (GO:2000104)2.31296754
184regulation of gene expression by genetic imprinting (GO:0006349)2.31145982
185embryonic cranial skeleton morphogenesis (GO:0048701)2.30514722
186regulation of smoothened signaling pathway (GO:0008589)2.28492177
187negative regulation of chondrocyte differentiation (GO:0032331)2.27235833
188cell proliferation involved in metanephros development (GO:0072203)2.26921731
189regulation of establishment of cell polarity (GO:2000114)2.26848951
190sister chromatid segregation (GO:0000819)2.26126815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.92472428
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.43511553
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.12981217
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.78225106
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.64770606
6EZH2_22144423_ChIP-Seq_EOC_Human3.51852072
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.92506708
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.69009357
9ZNF274_21170338_ChIP-Seq_K562_Hela2.61173102
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.58237506
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48788551
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.43217810
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.39646854
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39053604
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34334403
16FUS_26573619_Chip-Seq_HEK293_Human2.25728589
17TAF15_26573619_Chip-Seq_HEK293_Human2.19509057
18HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.18192721
19* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09193960
20IRF1_19129219_ChIP-ChIP_H3396_Human2.04332786
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04247590
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.99605836
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97210410
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.96497554
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.92798346
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89347957
27EWS_26573619_Chip-Seq_HEK293_Human1.88310029
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.86062943
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77474176
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71790253
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71738517
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64846620
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.60198365
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.58014967
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56825349
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.56209966
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55387365
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54866633
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54568218
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53348493
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53047752
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.51268255
43* MYC_18940864_ChIP-ChIP_HL60_Human1.49563892
44GBX2_23144817_ChIP-Seq_PC3_Human1.48756153
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47682260
46FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.46098167
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.45770656
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.45271721
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45207737
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44997747
51ER_23166858_ChIP-Seq_MCF-7_Human1.44767176
52TP53_16413492_ChIP-PET_HCT116_Human1.44321145
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43784904
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43653105
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39887131
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.37886649
57BCAT_22108803_ChIP-Seq_LS180_Human1.37588624
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37563418
59* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36872469
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35158645
61P300_19829295_ChIP-Seq_ESCs_Human1.34525802
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.34137034
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33875595
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32588086
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30997089
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30997089
67* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30579428
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.30334950
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29485917
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28790065
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28677502
72ISL1_27105846_Chip-Seq_CPCs_Mouse1.27417646
73AR_25329375_ChIP-Seq_VCAP_Human1.27139397
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26377014
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25942743
76CBP_20019798_ChIP-Seq_JUKART_Human1.25942743
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24974987
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22967737
79AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22774676
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21334519
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20801771
82BRD4_25478319_ChIP-Seq_HGPS_Human1.20299382
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19973306
84EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19973306
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18354082
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18346548
87IGF1R_20145208_ChIP-Seq_DFB_Human1.18043279
88SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16087605
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15878626
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.15065084
91* RNF2_27304074_Chip-Seq_NSC_Mouse1.14592557
92RUNX2_22187159_ChIP-Seq_PCA_Human1.14335528
93GF1B_26923725_Chip-Seq_HPCs_Mouse1.13384806
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.12430345
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.12269591
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12226871
97STAT3_23295773_ChIP-Seq_U87_Human1.12087076
98SMAD4_21741376_ChIP-Seq_EPCs_Human1.12043130
99PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10962775
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09707292
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09455250
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09442646
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08690884
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08690884
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08690884
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.08160832
107ELK1_19687146_ChIP-ChIP_HELA_Human1.08149867
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07798871
109AR_21909140_ChIP-Seq_LNCAP_Human1.07750539
110TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06519136
111SMAD4_21799915_ChIP-Seq_A2780_Human1.06150016
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.05634738
113TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04858732
114TCF4_22108803_ChIP-Seq_LS180_Human1.04510334
115EST1_17652178_ChIP-ChIP_JURKAT_Human1.04082515
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03948982
117TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03633971
118EP300_21415370_ChIP-Seq_HL-1_Mouse1.03410317
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.03343585
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03244862
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02807852
122SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02323997
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02220169
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01954837
125TCF4_23295773_ChIP-Seq_U87_Human1.01539433
126SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01420314
127SOX9_26525672_Chip-Seq_HEART_Mouse1.01158897
128NANOG_19829295_ChIP-Seq_ESCs_Human1.00921827
129CBX2_27304074_Chip-Seq_ESCs_Mouse0.97938540
130P53_22387025_ChIP-Seq_ESCs_Mouse0.95135661
131STAT3_18555785_Chip-Seq_ESCs_Mouse0.94590549
132PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94343093
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93957976
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.93905348
135DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93244549
136SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92991020
137* LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92215116
138CMYC_18555785_Chip-Seq_ESCs_Mouse0.91840539
139TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91202280
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90853455
141EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90842365
142POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90721757
143YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89779744
144NANOG_21062744_ChIP-ChIP_HESCs_Human0.89581991
145GATA1_26923725_Chip-Seq_HPCs_Mouse0.89145775
146PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88553190
147VDR_22108803_ChIP-Seq_LS180_Human0.88529871
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.88367880
149NANOG_16153702_ChIP-ChIP_HESCs_Human0.87495676
150AHR_22903824_ChIP-Seq_MCF-7_Human0.87395842
151STAT3_18555785_ChIP-Seq_MESCs_Mouse0.86981208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.32707857
2MP0002938_white_spotting2.83303403
3MP0003121_genomic_imprinting2.80357312
4MP0010030_abnormal_orbit_morphology2.67899650
5MP0006292_abnormal_olfactory_placode2.66849891
6MP0002653_abnormal_ependyma_morphology2.65890351
7MP0003122_maternal_imprinting2.59557990
8MP0001485_abnormal_pinna_reflex2.56617553
9MP0005646_abnormal_pituitary_gland2.49420290
10MP0008877_abnormal_DNA_methylation2.39143463
11MP0003937_abnormal_limbs/digits/tail_de2.35192802
12MP0002160_abnormal_reproductive_system2.32243436
13MP0003787_abnormal_imprinting2.31599335
14MP0002102_abnormal_ear_morphology2.25942576
15MP0009250_abnormal_appendicular_skeleto2.25078220
16MP0003123_paternal_imprinting2.24665840
17MP0002837_dystrophic_cardiac_calcinosis2.22639808
18MP0005670_abnormal_white_adipose2.18301016
19MP0005367_renal/urinary_system_phenotyp2.15261035
20MP0000516_abnormal_urinary_system2.15261035
21MP0008057_abnormal_DNA_replication2.13233718
22MP0003941_abnormal_skin_development2.07057361
23MP0000631_abnormal_neuroendocrine_gland2.05405037
24MP0008007_abnormal_cellular_replicative2.04585604
25MP0010094_abnormal_chromosome_stability1.93815254
26MP0002249_abnormal_larynx_morphology1.91362947
27MP0001346_abnormal_lacrimal_gland1.90339988
28MP0003693_abnormal_embryo_hatching1.83569993
29MP0003890_abnormal_embryonic-extraembry1.82836899
30MP0004133_heterotaxia1.73774879
31MP0000383_abnormal_hair_follicle1.73736332
32MP0003077_abnormal_cell_cycle1.71991665
33MP0009053_abnormal_anal_canal1.71766145
34MP0008058_abnormal_DNA_repair1.70828625
35MP0004885_abnormal_endolymph1.70708613
36MP0000569_abnormal_digit_pigmentation1.69488800
37MP0001293_anophthalmia1.67307921
38MP0000013_abnormal_adipose_tissue1.63310324
39MP0005389_reproductive_system_phenotype1.62360952
40MP0005248_abnormal_Harderian_gland1.61960876
41MP0003385_abnormal_body_wall1.60064627
42MP0003755_abnormal_palate_morphology1.58869898
43MP0000428_abnormal_craniofacial_morphol1.57885447
44MP0009384_cardiac_valve_regurgitation1.56767863
45MP0003111_abnormal_nucleus_morphology1.55367647
46MP0000678_abnormal_parathyroid_gland1.53022076
47MP0003935_abnormal_craniofacial_develop1.52643134
48MP0001188_hyperpigmentation1.46945651
49MP0003646_muscle_fatigue1.46680512
50MP0001661_extended_life_span1.44839815
51MP0010307_abnormal_tumor_latency1.44824247
52MP0002751_abnormal_autonomic_nervous1.41909582
53MP0004215_abnormal_myocardial_fiber1.40626401
54MP0000579_abnormal_nail_morphology1.40216787
55MP0002282_abnormal_trachea_morphology1.39766741
56MP0000049_abnormal_middle_ear1.39712659
57MP0001299_abnormal_eye_distance/1.38950872
58MP0004145_abnormal_muscle_electrophysio1.36619343
59MP0002009_preneoplasia1.34221628
60MP0002234_abnormal_pharynx_morphology1.34157680
61MP0010678_abnormal_skin_adnexa1.32197689
62MP0003942_abnormal_urinary_system1.32172792
63MP0002098_abnormal_vibrissa_morphology1.30836141
64MP0004134_abnormal_chest_morphology1.30584936
65MP0005551_abnormal_eye_electrophysiolog1.30583580
66MP0005187_abnormal_penis_morphology1.30527969
67MP0000432_abnormal_head_morphology1.29910174
68MP0003283_abnormal_digestive_organ1.29243326
69MP0002638_abnormal_pupillary_reflex1.29112073
70MP0002233_abnormal_nose_morphology1.26915952
71MP0002138_abnormal_hepatobiliary_system1.26700083
72MP0002109_abnormal_limb_morphology1.24972488
73MP0005253_abnormal_eye_physiology1.24685374
74MP0002177_abnormal_outer_ear1.24492863
75MP0005394_taste/olfaction_phenotype1.22076682
76MP0005499_abnormal_olfactory_system1.22076682
77MP0005408_hypopigmentation1.22006867
78MP0005076_abnormal_cell_differentiation1.20203620
79MP0009697_abnormal_copulation1.20105018
80MP0003938_abnormal_ear_development1.19370146
81MP0000778_abnormal_nervous_system1.18940295
82MP0003718_maternal_effect1.18488660
83MP0002116_abnormal_craniofacial_bone1.18482207
84MP0002085_abnormal_embryonic_tissue1.18120214
85MP0003315_abnormal_perineum_morphology1.17290096
86MP0003136_yellow_coat_color1.17163708
87MP0002084_abnormal_developmental_patter1.17159553
88MP0004130_abnormal_muscle_cell1.16610515
89MP0002877_abnormal_melanocyte_morpholog1.14632501
90MP0001286_abnormal_eye_development1.13845216
91MP0000762_abnormal_tongue_morphology1.12650175
92MP0004957_abnormal_blastocyst_morpholog1.12386304
93MP0004142_abnormal_muscle_tone1.11988491
94MP0003880_abnormal_central_pattern1.11519048
95MP0001119_abnormal_female_reproductive1.09858477
96MP0000537_abnormal_urethra_morphology1.07978941
97MP0003943_abnormal_hepatobiliary_system1.07415685
98MP0005195_abnormal_posterior_eye1.06357334
99MP0000026_abnormal_inner_ear1.04547744
100MP0003567_abnormal_fetal_cardiomyocyte1.04465718
101MP0000427_abnormal_hair_cycle1.04395165
102MP0001672_abnormal_embryogenesis/_devel1.03040942
103MP0005380_embryogenesis_phenotype1.03040942
104MP0005451_abnormal_body_composition1.02102760
105MP0008932_abnormal_embryonic_tissue1.01130605
106MP0001963_abnormal_hearing_physiology1.00941921
107MP0003786_premature_aging1.00715434
108MP0000534_abnormal_ureter_morphology0.98578227
109MP0008789_abnormal_olfactory_epithelium0.98532490
110MP0004808_abnormal_hematopoietic_stem0.98222052
111MP0000350_abnormal_cell_proliferation0.98007424
112MP0002163_abnormal_gland_morphology0.97284903
113MP0008775_abnormal_heart_ventricle0.97075953
114MP0002210_abnormal_sex_determination0.96932194
115MP0009703_decreased_birth_body0.96915885
116MP0001879_abnormal_lymphatic_vessel0.96092557
117MP0004197_abnormal_fetal_growth/weight/0.95952672
118MP0010368_abnormal_lymphatic_system0.95772469
119MP0006276_abnormal_autonomic_nervous0.95514110
120MP0005503_abnormal_tendon_morphology0.94726771
121MP0002127_abnormal_cardiovascular_syste0.92911295
122MP0002932_abnormal_joint_morphology0.89406248
123MP0002272_abnormal_nervous_system0.88441533
124MP0002111_abnormal_tail_morphology0.88423084
125MP0002088_abnormal_embryonic_growth/wei0.88384636
126MP0002114_abnormal_axial_skeleton0.87693434
127MP0002115_abnormal_skeleton_extremities0.87536955
128MP0005508_abnormal_skeleton_morphology0.86989433
129* MP0001697_abnormal_embryo_size0.86882553
130MP0003984_embryonic_growth_retardation0.86500028
131MP0003936_abnormal_reproductive_system0.85732267
132MP0001529_abnormal_vocalization0.84718917
133MP0002876_abnormal_thyroid_physiology0.82730710
134MP0006072_abnormal_retinal_apoptosis0.81106614
135MP0005084_abnormal_gallbladder_morpholo0.80941600
136MP0005174_abnormal_tail_pigmentation0.80836419
137MP0000163_abnormal_cartilage_morphology0.80562353
138MP0002086_abnormal_extraembryonic_tissu0.80276020
139MP0004085_abnormal_heartbeat0.80009170
140MP0002697_abnormal_eye_size0.80001121
141* MP0000653_abnormal_sex_gland0.79755403
142MP0003115_abnormal_respiratory_system0.78530851
143* MP0001145_abnormal_male_reproductive0.77594567
144MP0002925_abnormal_cardiovascular_devel0.77463621
145MP0000462_abnormal_digestive_system0.77117077
146MP0001270_distended_abdomen0.76670440
147MP0000372_irregular_coat_pigmentation0.75617804
148MP0000613_abnormal_salivary_gland0.75115396
149MP0004272_abnormal_basement_membrane0.74601715
150MP0003195_calcinosis0.73992350
151MP0005391_vision/eye_phenotype0.73727122
152MP0003119_abnormal_digestive_system0.73482219
153MP0002752_abnormal_somatic_nervous0.73213071
154MP0003137_abnormal_impulse_conducting0.72936655
155MP0008872_abnormal_physiological_respon0.72276998
156MP0009046_muscle_twitch0.70810683
157MP0002928_abnormal_bile_duct0.70768890

Predicted human phenotypes

RankGene SetZ-score
1Short 1st metacarpal (HP:0010034)5.00217419
2Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.00217419
3Short 4th metacarpal (HP:0010044)4.60664785
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.60664785
5Stenosis of the external auditory canal (HP:0000402)4.58604465
6Abnormality of the 1st metacarpal (HP:0010009)4.35997072
7Abnormality of the renal collecting system (HP:0004742)3.70980021
8Short hallux (HP:0010109)3.67334329
9Carpal bone hypoplasia (HP:0001498)3.67179320
10Aplasia/Hypoplasia of the hallux (HP:0008362)3.52948313
11Midline defect of the nose (HP:0004122)3.50062171
12Abnormality of the parietal bone (HP:0002696)3.47737178
13Short phalanx of the thumb (HP:0009660)3.40549547
14Abnormality of the proximal phalanges of the hand (HP:0009834)3.31657455
15Medulloblastoma (HP:0002885)3.21417068
16Duplicated collecting system (HP:0000081)3.17501677
17Absent thumb (HP:0009777)3.17168031
18Prostate neoplasm (HP:0100787)3.13087947
19True hermaphroditism (HP:0010459)3.11066405
20Chromsome breakage (HP:0040012)3.03281517
21Abnormality of the 4th metacarpal (HP:0010012)3.02760532
22Abnormality of the nasal septum (HP:0000419)3.01582120
23Abnormality of the distal phalanx of the thumb (HP:0009617)2.99157919
24Abnormality of the labia minora (HP:0012880)2.96891375
25Abnormality of the phalanges of the hallux (HP:0010057)2.96025549
26Abnormality of DNA repair (HP:0003254)2.94130213
27Abnormality of the middle phalanges of the toes (HP:0010183)2.94049014
28Synostosis of carpal bones (HP:0005048)2.90316425
29Papillary thyroid carcinoma (HP:0002895)2.89668641
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.89512729
31Pancreatic fibrosis (HP:0100732)2.84776138
32Pendular nystagmus (HP:0012043)2.83082538
33Pancreatic cysts (HP:0001737)2.81445527
34Fused cervical vertebrae (HP:0002949)2.81372924
35Ectopic kidney (HP:0000086)2.72533445
36Anterior segment dysgenesis (HP:0007700)2.71666282
37Osteomalacia (HP:0002749)2.62616397
38Nephronophthisis (HP:0000090)2.61035685
39Hypoplastic labia majora (HP:0000059)2.60935314
40Trigonocephaly (HP:0000243)2.55624950
41Oligodactyly (HP:0012165)2.54424489
42Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.53893843
43Short middle phalanx of the 5th finger (HP:0004220)2.50547241
44Rectovaginal fistula (HP:0000143)2.48952830
45Rectal fistula (HP:0100590)2.48952830
46Absent eyebrow (HP:0002223)2.46756666
47Lip pit (HP:0100267)2.44910756
48Abnormality of the phalanges of the 2nd finger (HP:0009541)2.43707289
49Morphological abnormality of the middle ear (HP:0008609)2.38945033
50Abnormality of the labia majora (HP:0012881)2.36620310
51Short humerus (HP:0005792)2.34202754
52Chorioretinal atrophy (HP:0000533)2.30062740
53Broad thumb (HP:0011304)2.29531782
54Maternal diabetes (HP:0009800)2.28269005
55Facial hemangioma (HP:0000329)2.26975733
56Hypoplasia of the ulna (HP:0003022)2.26802364
57Mesomelia (HP:0003027)2.26657343
58Acute myeloid leukemia (HP:0004808)2.26451024
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.24060554
60Aplasia/hypoplasia of the humerus (HP:0006507)2.23689191
61Nephroblastoma (Wilms tumor) (HP:0002667)2.23333567
62Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.23148262
63Microglossia (HP:0000171)2.22849583
64Abolished electroretinogram (ERG) (HP:0000550)2.22668821
65Abnormality of the incisor (HP:0000676)2.21491406
66Abnormality of the fingertips (HP:0001211)2.20270776
67Neoplasm of the oral cavity (HP:0100649)2.19563916
68Anal stenosis (HP:0002025)2.18750951
69Volvulus (HP:0002580)2.18734227
70Chronic hepatic failure (HP:0100626)2.16949867
71Symphalangism affecting the phalanges of the hand (HP:0009773)2.16673925
72Abnormality of midbrain morphology (HP:0002418)2.16640262
73Molar tooth sign on MRI (HP:0002419)2.16640262
74Reticulocytopenia (HP:0001896)2.14616393
75Deep philtrum (HP:0002002)2.14501572
76Abnormality of the renal medulla (HP:0100957)2.14181811
77Birth length less than 3rd percentile (HP:0003561)2.13862507
78Embryonal renal neoplasm (HP:0011794)2.13152065
79Preaxial foot polydactyly (HP:0001841)2.12699334
80Aplasia/Hypoplasia of the tibia (HP:0005772)2.12576211
81Cutaneous finger syndactyly (HP:0010554)2.12071913
82Synostosis involving the elbow (HP:0003938)2.11619571
83Humeroradial synostosis (HP:0003041)2.11619571
84Horseshoe kidney (HP:0000085)2.11493997
85Chin dimple (HP:0010751)2.11464944
86Abnormal number of incisors (HP:0011064)2.10363065
87Abnormality of incisor morphology (HP:0011063)2.09492549
88Bifid tongue (HP:0010297)2.09130615
89Increased corneal curvature (HP:0100692)2.08354060
90Keratoconus (HP:0000563)2.08354060
91Abnormality of the parathyroid morphology (HP:0011766)2.08174032
92Congenital sensorineural hearing impairment (HP:0008527)2.08026240
93Meckel diverticulum (HP:0002245)2.07336113
94Short tibia (HP:0005736)2.05197025
95Genetic anticipation (HP:0003743)2.04841474
96Abnormality of the ileum (HP:0001549)2.03509205
97Septo-optic dysplasia (HP:0100842)2.03419670
98Abnormality of the nasolacrimal system (HP:0000614)2.02827469
99Supernumerary ribs (HP:0005815)2.02548089
100Abnormality of the lacrimal duct (HP:0011481)2.01412631
101Supernumerary bones of the axial skeleton (HP:0009144)2.01204974
102Intestinal atresia (HP:0011100)2.00902727
103Abnormality of the carotid arteries (HP:0005344)1.99397359
104Congenital stationary night blindness (HP:0007642)1.98890279
105Intestinal fistula (HP:0100819)1.98665372
106Hepatoblastoma (HP:0002884)1.98550178
107Absent forearm bone (HP:0003953)1.98392068
108Aplasia involving forearm bones (HP:0009822)1.98392068
109Depressed nasal tip (HP:0000437)1.98302313
110Aplasia/Hypoplasia of the uvula (HP:0010293)1.97835605
111Absent radius (HP:0003974)1.97452933
112Congenital, generalized hypertrichosis (HP:0004540)1.96965872
113Methylmalonic acidemia (HP:0002912)1.96635686
114Oligodactyly (hands) (HP:0001180)1.94865797
115Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.93455223
116Long eyelashes (HP:0000527)1.91757028
117Neoplasm of striated muscle (HP:0009728)1.90720825
118Glioma (HP:0009733)1.90347548
119Aplasia/Hypoplasia of the ulna (HP:0006495)1.90292823
120Increased number of teeth (HP:0011069)1.90128660
121Abnormality of chromosome stability (HP:0003220)1.89222336
122Adactyly (HP:0009776)1.88410153
123Tented upper lip vermilion (HP:0010804)1.88205458
124Carpal synostosis (HP:0009702)1.88026011
125Duplication of thumb phalanx (HP:0009942)1.87648249
126Cutaneous syndactyly (HP:0012725)1.87280314
127Broad toe (HP:0001837)1.87150209
128Nasolacrimal duct obstruction (HP:0000579)1.86980046
129Abnormality of the renal cortex (HP:0011035)1.85624326
130Absent/shortened dynein arms (HP:0200106)1.85254852
131Dynein arm defect of respiratory motile cilia (HP:0012255)1.85254852
132Vertebral fusion (HP:0002948)1.85132152
133Renal hypoplasia (HP:0000089)1.85042913
134Vaginal fistula (HP:0004320)1.83959192
135Vitreoretinal degeneration (HP:0000655)1.83380248
136Aplasia/Hypoplasia involving the musculature (HP:0001460)1.82262032
137Thyroid-stimulating hormone excess (HP:0002925)1.79969404
138Abnormality of the preputium (HP:0100587)1.79248499
139Hypoplastic ischia (HP:0003175)1.79112745
140Rhabdomyosarcoma (HP:0002859)1.78272669
141Acute lymphatic leukemia (HP:0006721)1.77757693
142Hemivertebrae (HP:0002937)1.77146895
143Small intestinal stenosis (HP:0012848)1.76545887
144Duodenal stenosis (HP:0100867)1.76545887
145Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.76520095
146Cupped ear (HP:0000378)1.76487956
147Abnormality of the phalanges of the 5th finger (HP:0004213)1.76131969
148Aplasia/Hypoplasia of the tongue (HP:0010295)1.75904394
149Sclerocornea (HP:0000647)1.75724494
150Aplasia/Hypoplasia of the sternum (HP:0006714)1.75333250
151Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.74178968
152Capillary hemangiomas (HP:0005306)1.73500010
153Aplasia involving bones of the upper limbs (HP:0009823)1.73252428
154Aplasia of the phalanges of the hand (HP:0009802)1.73252428
155Aplasia involving bones of the extremities (HP:0009825)1.73252428
156Cystic liver disease (HP:0006706)1.72911063
157Rib fusion (HP:0000902)1.72553061
158Hypoplasia of the uterus (HP:0000013)1.72234758
159Anomalous pulmonary venous return (HP:0010772)1.71660532
1602-3 toe syndactyly (HP:0004691)1.71393556
161White forelock (HP:0002211)1.71236793
162Broad phalanges of the hand (HP:0009768)1.70805028
163Partial duplication of the phalanx of hand (HP:0009999)1.70358121
164Adrenal hypoplasia (HP:0000835)1.69892537
165Shallow orbits (HP:0000586)1.68862604
166Fibular aplasia (HP:0002990)1.68600290
167Supernumerary spleens (HP:0009799)1.67480316
168Triphalangeal thumb (HP:0001199)1.66797306
169Abnormality of the diencephalon (HP:0010662)1.66632600
170Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.66573083
171Ependymoma (HP:0002888)1.65702328
172Skin pits (HP:0100276)1.65492537
173Short thumb (HP:0009778)1.65021532
174Broad phalanx (HP:0006009)1.64213667
175Alacrima (HP:0000522)1.64142098
176Stomach cancer (HP:0012126)1.63802299
177Anophthalmia (HP:0000528)1.63590006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.63023830
2AKT34.03211571
3PIK3CG3.38610570
4GRK13.28159083
5FRK2.73949128
6PLK42.55008304
7ADRBK22.45705001
8BRAF2.44325263
9STK38L2.24535157
10MAP4K22.14492745
11TNIK2.11437858
12ACVR1B2.08319595
13TLK12.03963660
14CDC72.01534815
15STK31.97211374
16SGK21.94033811
17BRSK21.93573495
18MAP3K131.84154090
19TRIM281.82965999
20CDK121.82100984
21BMPR1B1.80208587
22MKNK21.79121280
23TTK1.76651919
24ZAK1.72911869
25PIK3CA1.66931595
26ERBB41.63773897
27MAP3K41.62139871
28FGFR21.60253418
29MKNK11.60050748
30TIE11.59320743
31LATS21.57620112
32NUAK11.57368214
33CASK1.53171082
34FLT31.51705126
35BLK1.50525691
36BRD41.49577869
37NEK91.38769541
38PLK31.34096967
39TAF11.33296049
40PINK11.32466900
41CHUK1.28082465
42WNK41.23393000
43MAP3K141.18510257
44EPHA41.18333112
45SGK31.17560586
46CDK81.16920014
47RPS6KA41.16797507
48TGFBR11.16634558
49CHEK21.15997474
50BCKDK1.13681784
51CAMK1D1.13354181
52ATM1.11825578
53SGK4941.11585328
54SGK2231.11585328
55STK41.07548412
56ERBB31.06745633
57EPHB21.05357475
58PLK11.04289850
59ATR1.03489774
60GRK71.03180447
61SRPK11.03142011
62CHEK10.99230163
63STK160.98760217
64STK390.95508288
65PASK0.95366653
66MELK0.94274419
67DDR20.93409618
68MAP3K60.92745721
69MAP2K70.92089644
70CDK30.89734881
71PNCK0.89127603
72NLK0.87708993
73TRPM70.87275829
74WEE10.87217430
75CDK70.84771662
76VRK10.84303497
77TXK0.81368876
78INSRR0.80696911
79EIF2AK20.79989034
80NEK20.79171977
81PRKCE0.78307972
82PIM10.77054732
83FGFR10.76776279
84CSNK1G10.75869961
85CLK10.74952141
86ADRBK10.74779626
87KSR10.73240341
88DYRK20.72537711
89PDGFRB0.72527139
90SIK30.71822526
91EIF2AK30.71725116
92FGFR30.71070464
93EPHA30.71029729
94CDK190.70360304
95AURKB0.69114227
96BUB10.68560188
97PRKD30.67605710
98NEK60.66687020
99WNK10.66349112
100STK240.65706651
101RAF10.65223353
102AURKA0.62575705
103TAOK30.61020427
104MAP2K10.60360168
105CDK90.60259071
106OBSCN0.60239134
107CSNK1G20.58617764
108AKT10.56242850
109RPS6KB20.56006382
110TEC0.55627361
111IKBKB0.55338769
112NEK10.54314261
113CSNK1A10.53427501
114OXSR10.53396747
115CDK10.52961255
116PRKAA20.52776809
117DMPK0.52493347
118YES10.51858814
119MAPK150.51553125
120CAMKK20.51208969
121MUSK0.51051986
122DYRK30.50779369
123CSNK1G30.50712685
124PRKACA0.49217509
125CDK20.49088199
126GRK50.48991550
127TAOK10.48369785
128PRKCG0.48114412
129SGK10.48036051
130PLK20.47428601
131PHKG10.46477573
132PHKG20.46477573
133MAPK130.46473038
134PAK30.45781990
135MAPK70.45622754
136NTRK20.45182329
137CAMK2A0.44348832
138CSNK1A1L0.44274292
139BCR0.43882165
140WNK30.43699071
141MAPK10.43506158
142MAPK140.42332327
143MTOR0.41014700
144CAMK1G0.40529393
145ERBB20.39814639
146KIT0.39269787
147RPS6KB10.38969991
148CAMK40.38709411
149CSNK1D0.38509769
150VRK20.37679142
151DYRK1A0.37335733
152MAP3K30.36815411
153RPS6KA60.35943699
154MAP3K80.34680188

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.60552966
2Fanconi anemia pathway_Homo sapiens_hsa034602.52066393
3Basal cell carcinoma_Homo sapiens_hsa052172.27582201
4Basal transcription factors_Homo sapiens_hsa030222.21468333
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.18752324
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99395319
7Mismatch repair_Homo sapiens_hsa034301.98145822
8RNA degradation_Homo sapiens_hsa030181.93937361
9Hedgehog signaling pathway_Homo sapiens_hsa043401.92293055
10Non-homologous end-joining_Homo sapiens_hsa034501.85611048
11Sulfur metabolism_Homo sapiens_hsa009201.85269578
12Homologous recombination_Homo sapiens_hsa034401.79452705
13Nicotine addiction_Homo sapiens_hsa050331.76531347
14Prostate cancer_Homo sapiens_hsa052151.69659962
15TGF-beta signaling pathway_Homo sapiens_hsa043501.64209303
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63604736
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.63281672
18Adherens junction_Homo sapiens_hsa045201.60853241
19Endometrial cancer_Homo sapiens_hsa052131.58742615
20Nitrogen metabolism_Homo sapiens_hsa009101.54263675
21Protein export_Homo sapiens_hsa030601.53945334
22MicroRNAs in cancer_Homo sapiens_hsa052061.52450870
23Ribosome_Homo sapiens_hsa030101.52150042
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49700190
25Colorectal cancer_Homo sapiens_hsa052101.49549665
26Thyroid cancer_Homo sapiens_hsa052161.47693867
27Melanoma_Homo sapiens_hsa052181.47070543
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.46024556
29p53 signaling pathway_Homo sapiens_hsa041151.42478975
30Selenocompound metabolism_Homo sapiens_hsa004501.41543980
31Propanoate metabolism_Homo sapiens_hsa006401.35516052
32Taste transduction_Homo sapiens_hsa047421.33352213
33Hippo signaling pathway_Homo sapiens_hsa043901.32479184
34mRNA surveillance pathway_Homo sapiens_hsa030151.32000177
35Pancreatic cancer_Homo sapiens_hsa052121.30583294
36RNA transport_Homo sapiens_hsa030131.30033512
37Morphine addiction_Homo sapiens_hsa050321.28654101
38Oxidative phosphorylation_Homo sapiens_hsa001901.26062034
39Small cell lung cancer_Homo sapiens_hsa052221.25897619
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25381458
41Olfactory transduction_Homo sapiens_hsa047401.24745209
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23522413
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22504558
44Cardiac muscle contraction_Homo sapiens_hsa042601.19268320
45Renin-angiotensin system_Homo sapiens_hsa046141.19143679
46Prolactin signaling pathway_Homo sapiens_hsa049171.18928884
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18488761
48Wnt signaling pathway_Homo sapiens_hsa043101.18232400
49Ether lipid metabolism_Homo sapiens_hsa005651.18118706
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16173702
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15416536
52Retinol metabolism_Homo sapiens_hsa008301.14113636
53Type II diabetes mellitus_Homo sapiens_hsa049301.12940449
54DNA replication_Homo sapiens_hsa030301.12118904
55Chemical carcinogenesis_Homo sapiens_hsa052041.11846332
56Base excision repair_Homo sapiens_hsa034101.11649052
57Nucleotide excision repair_Homo sapiens_hsa034201.07507258
58FoxO signaling pathway_Homo sapiens_hsa040681.04781340
59Acute myeloid leukemia_Homo sapiens_hsa052211.04340557
60Non-small cell lung cancer_Homo sapiens_hsa052231.03475567
61Parkinsons disease_Homo sapiens_hsa050121.02622584
62mTOR signaling pathway_Homo sapiens_hsa041501.02593463
63Huntingtons disease_Homo sapiens_hsa050161.01532278
64Ovarian steroidogenesis_Homo sapiens_hsa049131.01360370
65Chronic myeloid leukemia_Homo sapiens_hsa052200.99917241
66HTLV-I infection_Homo sapiens_hsa051660.99703308
67Pathways in cancer_Homo sapiens_hsa052000.99453450
68Herpes simplex infection_Homo sapiens_hsa051680.99017199
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.97567363
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95632205
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94878565
72Insulin secretion_Homo sapiens_hsa049110.94728664
73Proteoglycans in cancer_Homo sapiens_hsa052050.90892372
74Lysine degradation_Homo sapiens_hsa003100.90570682
75ErbB signaling pathway_Homo sapiens_hsa040120.89942233
76Viral carcinogenesis_Homo sapiens_hsa052030.89804917
77RNA polymerase_Homo sapiens_hsa030200.88743972
78Butanoate metabolism_Homo sapiens_hsa006500.88445199
79Circadian entrainment_Homo sapiens_hsa047130.88375713
80Sulfur relay system_Homo sapiens_hsa041220.87607217
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85260674
82One carbon pool by folate_Homo sapiens_hsa006700.84935697
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.84183330
84Circadian rhythm_Homo sapiens_hsa047100.83417981
85Alzheimers disease_Homo sapiens_hsa050100.83112154
86GABAergic synapse_Homo sapiens_hsa047270.82271819
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82153236
88Renal cell carcinoma_Homo sapiens_hsa052110.81837375
89Oocyte meiosis_Homo sapiens_hsa041140.81579061
90Axon guidance_Homo sapiens_hsa043600.81225957
91Regulation of autophagy_Homo sapiens_hsa041400.80287396
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80067837
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79731613
94TNF signaling pathway_Homo sapiens_hsa046680.79380871
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.78406350
96Peroxisome_Homo sapiens_hsa041460.76268773
97Spliceosome_Homo sapiens_hsa030400.74784274
98Hepatitis B_Homo sapiens_hsa051610.74563763
99Glioma_Homo sapiens_hsa052140.74023131
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73809717
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.73591499
102ECM-receptor interaction_Homo sapiens_hsa045120.73453230
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73354335
104Systemic lupus erythematosus_Homo sapiens_hsa053220.72933850
105Glycerolipid metabolism_Homo sapiens_hsa005610.72200357
106Glutamatergic synapse_Homo sapiens_hsa047240.72094083
107Tryptophan metabolism_Homo sapiens_hsa003800.71695192
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71302557
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71236507
110Steroid biosynthesis_Homo sapiens_hsa001000.70007821
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70007707
112Toxoplasmosis_Homo sapiens_hsa051450.69343506
113Caffeine metabolism_Homo sapiens_hsa002320.69104293
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69005980
115Serotonergic synapse_Homo sapiens_hsa047260.67381546
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66776514
117Bladder cancer_Homo sapiens_hsa052190.66080704
118Fat digestion and absorption_Homo sapiens_hsa049750.65893799
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.65156836
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.65043057
121Notch signaling pathway_Homo sapiens_hsa043300.64961306
122Vitamin digestion and absorption_Homo sapiens_hsa049770.64291353
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64006318
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63948405
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63936908
126Influenza A_Homo sapiens_hsa051640.63379700
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.62285607
128Melanogenesis_Homo sapiens_hsa049160.62281567
129Focal adhesion_Homo sapiens_hsa045100.62231041
130Arachidonic acid metabolism_Homo sapiens_hsa005900.62180516
131Calcium signaling pathway_Homo sapiens_hsa040200.61944536
132Epstein-Barr virus infection_Homo sapiens_hsa051690.61326289
133Choline metabolism in cancer_Homo sapiens_hsa052310.60809888
134Purine metabolism_Homo sapiens_hsa002300.60752099
135Dilated cardiomyopathy_Homo sapiens_hsa054140.59329031
136Ras signaling pathway_Homo sapiens_hsa040140.58859459
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58081787
138Rap1 signaling pathway_Homo sapiens_hsa040150.57568873
139Phototransduction_Homo sapiens_hsa047440.57025649
140Measles_Homo sapiens_hsa051620.56877321
141Renin secretion_Homo sapiens_hsa049240.56323546
142Dorso-ventral axis formation_Homo sapiens_hsa043200.55651794
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54886906
144Protein digestion and absorption_Homo sapiens_hsa049740.53682606
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53051462
146Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52362395
147Linoleic acid metabolism_Homo sapiens_hsa005910.51510863
148cAMP signaling pathway_Homo sapiens_hsa040240.50780049
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50238235
150Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48941595
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48939755
152Alcoholism_Homo sapiens_hsa050340.47680032
153MAPK signaling pathway_Homo sapiens_hsa040100.47377626
154Type I diabetes mellitus_Homo sapiens_hsa049400.46334060
155Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46017942
156Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43928270
157Hematopoietic cell lineage_Homo sapiens_hsa046400.43385406
158Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43126137
159Platelet activation_Homo sapiens_hsa046110.43026981

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