PLA2R1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)9.06679153
2rhodopsin mediated signaling pathway (GO:0016056)8.95720933
3photoreceptor cell maintenance (GO:0045494)6.74060290
4photoreceptor cell development (GO:0042461)6.68517645
5retinal cone cell development (GO:0046549)6.67016728
6eye photoreceptor cell development (GO:0042462)6.54419466
7detection of light stimulus involved in visual perception (GO:0050908)6.39552087
8detection of light stimulus involved in sensory perception (GO:0050962)6.39552087
9retinal rod cell development (GO:0046548)5.90954984
10phototransduction, visible light (GO:0007603)5.33363127
11phototransduction (GO:0007602)5.20179183
12detection of visible light (GO:0009584)5.18918227
13protein-chromophore linkage (GO:0018298)5.13080853
14detection of light stimulus (GO:0009583)5.02873879
15visual perception (GO:0007601)4.69738910
16photoreceptor cell differentiation (GO:0046530)4.69670930
17eye photoreceptor cell differentiation (GO:0001754)4.69670930
18sensory perception of light stimulus (GO:0050953)4.65811621
19cellular glucuronidation (GO:0052695)4.55031923
20uronic acid metabolic process (GO:0006063)4.50876559
21glucuronate metabolic process (GO:0019585)4.50876559
22inner ear receptor cell differentiation (GO:0060113)4.44084779
23regulation of skeletal muscle contraction (GO:0014819)4.17145756
24GMP metabolic process (GO:0046037)4.04181701
25positive regulation of guanylate cyclase activity (GO:0031284)4.02779718
26smooth muscle tissue development (GO:0048745)3.83475127
27energy homeostasis (GO:0097009)3.73915556
28mechanoreceptor differentiation (GO:0042490)3.65680507
29glomerulus development (GO:0032835)3.63272924
30one-carbon compound transport (GO:0019755)3.60088101
31detection of external stimulus (GO:0009581)3.55818043
32detection of abiotic stimulus (GO:0009582)3.54533422
33estrogen biosynthetic process (GO:0006703)3.52464214
34regulation of guanylate cyclase activity (GO:0031282)3.49648281
35xenobiotic catabolic process (GO:0042178)3.45026802
36retina development in camera-type eye (GO:0060041)3.40075578
37cell differentiation involved in metanephros development (GO:0072202)3.35830039
38cellular response to light stimulus (GO:0071482)3.35517147
39regulation of hippo signaling (GO:0035330)3.22780591
40regulation of cGMP metabolic process (GO:0030823)3.21252577
41regulation of sequestering of triglyceride (GO:0010889)3.17307375
42hemidesmosome assembly (GO:0031581)3.12922681
43negative regulation of transcription regulatory region DNA binding (GO:2000678)3.12253370
44regulation of chemokine secretion (GO:0090196)3.07671539
45retina layer formation (GO:0010842)3.05759084
46nonmotile primary cilium assembly (GO:0035058)3.04841759
47dentate gyrus development (GO:0021542)3.03507793
48positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.02542703
49regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.99795307
50bone remodeling (GO:0046849)2.99707030
51positive regulation of fatty acid oxidation (GO:0046321)2.99073544
52nucleotide transmembrane transport (GO:1901679)2.96563605
53lymphangiogenesis (GO:0001946)2.95320169
54protein heterotrimerization (GO:0070208)2.93910230
55negative regulation of axon extension involved in axon guidance (GO:0048843)2.92907552
56mesenchymal-epithelial cell signaling (GO:0060638)2.90600566
57mesenchymal cell differentiation involved in kidney development (GO:0072161)2.89177164
58mesenchymal cell differentiation involved in renal system development (GO:2001012)2.89177164
59behavioral response to nicotine (GO:0035095)2.87621206
60positive regulation of cGMP biosynthetic process (GO:0030828)2.82537701
61negative regulation of protein localization to cell surface (GO:2000009)2.80118941
62metanephric mesenchyme development (GO:0072075)2.80058472
63keratinization (GO:0031424)2.78455043
64positive regulation of cGMP metabolic process (GO:0030825)2.77139303
65parturition (GO:0007567)2.74988939
66detection of molecule of bacterial origin (GO:0032490)2.74681350
67artery development (GO:0060840)2.73842146
68auditory receptor cell stereocilium organization (GO:0060088)2.72265445
69cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.70034964
70mesenchyme morphogenesis (GO:0072132)2.68787919
71lateral sprouting from an epithelium (GO:0060601)2.67862525
72polyol transport (GO:0015791)2.67366574
73pericardium development (GO:0060039)2.67265330
74regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.67067332
75positive regulation of glomerulus development (GO:0090193)2.66870814
76collagen fibril organization (GO:0030199)2.66807089
77sulfation (GO:0051923)2.64649413
78cell morphogenesis involved in neuron differentiation (GO:0048667)2.64210832
79kidney morphogenesis (GO:0060993)2.61844390
80endodermal cell differentiation (GO:0035987)2.61353796
81response to pheromone (GO:0019236)2.60744642
82endocardial cushion development (GO:0003197)2.60513224
83white fat cell differentiation (GO:0050872)2.59747760
84glomerular basement membrane development (GO:0032836)2.59617444
85regulation of cGMP biosynthetic process (GO:0030826)2.56748602
86import into cell (GO:0098657)2.56442899
87positive regulation of fatty acid beta-oxidation (GO:0032000)2.55759249
88chondrocyte proliferation (GO:0035988)2.55258828
89sensory perception (GO:0007600)2.55043419
90desmosome organization (GO:0002934)2.54574719
91cellular response to radiation (GO:0071478)2.53996265
92regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.53509368
93cellular potassium ion homeostasis (GO:0030007)2.52845461
94cell differentiation involved in kidney development (GO:0061005)2.52175536
95brown fat cell differentiation (GO:0050873)2.52151395
96kidney mesenchyme development (GO:0072074)2.50536622
97negative chemotaxis (GO:0050919)2.49500038
98sequestering of extracellular ligand from receptor (GO:0035581)2.48493817
99regulation of axon extension involved in axon guidance (GO:0048841)2.48443770
100phenylpropanoid metabolic process (GO:0009698)2.48078041
101negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.47029516
102dermatan sulfate biosynthetic process (GO:0030208)2.46176891
103response to nitrosative stress (GO:0051409)2.45616813
104superoxide anion generation (GO:0042554)2.44475333
105regulation of mesoderm development (GO:2000380)2.42342044
106negative regulation of mast cell activation (GO:0033004)2.42184388
107iron ion import (GO:0097286)2.40419572
108molting cycle (GO:0042303)2.40417409
109hair cycle (GO:0042633)2.40417409
110daunorubicin metabolic process (GO:0044597)2.40409456
111polyketide metabolic process (GO:0030638)2.40409456
112doxorubicin metabolic process (GO:0044598)2.40409456
113thyroid hormone metabolic process (GO:0042403)2.39693144
114negative regulation of osteoblast proliferation (GO:0033689)2.38689459
115ganglion development (GO:0061548)2.37786487
116negative regulation of systemic arterial blood pressure (GO:0003085)2.37680172
117positive regulation of phosphatase activity (GO:0010922)2.36892447
118cranial nerve structural organization (GO:0021604)2.36839048
119renal absorption (GO:0070293)2.36789062
120establishment of skin barrier (GO:0061436)2.36306217
121detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.36169055
122epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35834808
123positive regulation of respiratory burst (GO:0060267)2.35797517
124regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.35322959
125phosphatidylinositol acyl-chain remodeling (GO:0036149)2.34930635
126retina vasculature morphogenesis in camera-type eye (GO:0061299)2.34378870
127negative regulation of Rho protein signal transduction (GO:0035024)2.33382341
128surfactant homeostasis (GO:0043129)2.31637804
129phosphatidylserine acyl-chain remodeling (GO:0036150)2.31459937
130relaxation of cardiac muscle (GO:0055119)2.31125674
131embryonic cranial skeleton morphogenesis (GO:0048701)2.30809767
132endocardial cushion morphogenesis (GO:0003203)2.29533293
133urinary tract smooth muscle contraction (GO:0014848)2.28921489
134glomerular filtration (GO:0003094)2.28674558
135extracellular negative regulation of signal transduction (GO:1900116)2.28587381
136extracellular regulation of signal transduction (GO:1900115)2.28587381
137establishment of tissue polarity (GO:0007164)2.28439809
138establishment of planar polarity (GO:0001736)2.28439809
139androgen biosynthetic process (GO:0006702)2.26721938
140negative regulation of chondrocyte differentiation (GO:0032331)2.26597055
141regulation of glomerulus development (GO:0090192)2.26545506
142regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.26413691
143regulation of axon guidance (GO:1902667)2.25913371
144estrogen metabolic process (GO:0008210)2.25564889
145dermatan sulfate metabolic process (GO:0030205)2.24764263
146retinol metabolic process (GO:0042572)2.24533737
147atrial cardiac muscle cell action potential (GO:0086014)2.23864514
148neuron remodeling (GO:0016322)2.23049619
149pharyngeal system development (GO:0060037)2.22630890
150inner ear receptor stereocilium organization (GO:0060122)2.22282838
151blood vessel maturation (GO:0001955)2.21871731
152facial nerve structural organization (GO:0021612)2.21640724
153limb development (GO:0060173)2.21565821
154appendage development (GO:0048736)2.21565821
155negative regulation of keratinocyte proliferation (GO:0010839)2.20565194
156regulation of non-canonical Wnt signaling pathway (GO:2000050)2.20327973
157renal filtration (GO:0097205)2.20304964
158negative regulation of axon guidance (GO:1902668)2.20006439
159positive regulation of chemokine secretion (GO:0090197)2.19624641
160negative regulation of cardiac muscle tissue development (GO:0055026)2.19418011
161regulation of keratinocyte proliferation (GO:0010837)2.19258777
162regulation of cardioblast proliferation (GO:0003264)2.19148825
163regulation of secondary heart field cardioblast proliferation (GO:0003266)2.19148825
164membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.18769553
165cell proliferation involved in kidney development (GO:0072111)2.18291119
166cellular response to vitamin (GO:0071295)2.17849036
167ovulation cycle (GO:0042698)2.17667688
168Notch signaling involved in heart development (GO:0061314)2.17568275
169regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)2.16925836
170keratan sulfate catabolic process (GO:0042340)2.16382599
171positive regulation of cardiac muscle cell differentiation (GO:2000727)2.15705287
172wound healing, spreading of epidermal cells (GO:0035313)2.15669363
173neuron projection extension involved in neuron projection guidance (GO:1902284)2.15534556
174axon extension involved in axon guidance (GO:0048846)2.15534556
175head development (GO:0060322)2.14350668
176neuron development (GO:0048666)2.14196571
177cellular response to vitamin D (GO:0071305)2.13068300
178positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.12678319
179positive regulation of mesenchymal cell proliferation (GO:0002053)2.11644611
180substrate adhesion-dependent cell spreading (GO:0034446)2.11644137
181regulation of metanephros development (GO:0072215)2.08646198
182peptide cross-linking (GO:0018149)2.08389258
183negative regulation of nitric-oxide synthase activity (GO:0051001)2.08187978
184endothelial cell morphogenesis (GO:0001886)2.08089364
185vascular endothelial growth factor signaling pathway (GO:0038084)2.07973785
186reflex (GO:0060004)2.07933865
187positive regulation of metanephros development (GO:0072216)2.07189517
188auditory receptor cell differentiation (GO:0042491)2.06705368
189thyroid hormone generation (GO:0006590)2.05655108
190endocrine hormone secretion (GO:0060986)2.05403853
191adhesion of symbiont to host cell (GO:0044650)2.04987404
192virion attachment to host cell (GO:0019062)2.04987404
193smooth muscle contraction (GO:0006939)2.04659165
194regulation of mesenchymal cell proliferation (GO:0010464)2.03432187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.59685196
2BP1_19119308_ChIP-ChIP_Hs578T_Human2.69014100
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.68377613
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.43626159
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09807182
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.09400538
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07232000
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04586891
9PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.99086920
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.87102017
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84067330
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83069487
13CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80672602
14EED_16625203_ChIP-ChIP_MESCs_Mouse1.79690866
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78845259
16SMAD_19615063_ChIP-ChIP_OVARY_Human1.75525221
17AR_21572438_ChIP-Seq_LNCaP_Human1.72968131
18TAF15_26573619_Chip-Seq_HEK293_Human1.71347084
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70958286
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68157810
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66558948
22* PIAS1_25552417_ChIP-Seq_VCAP_Human1.66394333
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65258380
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63774860
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62708903
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62708903
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.60259784
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59555211
29AHR_22903824_ChIP-Seq_MCF-7_Human1.57919417
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57611193
31ZNF274_21170338_ChIP-Seq_K562_Hela1.55432071
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55287036
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54533066
34P300_19829295_ChIP-Seq_ESCs_Human1.54252220
35TP53_16413492_ChIP-PET_HCT116_Human1.53161369
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.52506525
37CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51612995
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51418231
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51237826
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.51042901
41TP53_18474530_ChIP-ChIP_U2OS_Human1.50129367
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49520200
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49477791
44* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49239876
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.46100222
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44446142
47SMAD4_21799915_ChIP-Seq_A2780_Human1.43299197
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42652292
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.40088204
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39461460
51* NANOG_18555785_Chip-Seq_ESCs_Mouse1.39315223
52* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39015571
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.38893643
54IGF1R_20145208_ChIP-Seq_DFB_Human1.38363524
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34932170
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34932170
57DROSHA_22980978_ChIP-Seq_HELA_Human1.34408316
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33443416
59VDR_22108803_ChIP-Seq_LS180_Human1.33043108
60* E2F1_18555785_Chip-Seq_ESCs_Mouse1.32546247
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.31205267
62EZH2_22144423_ChIP-Seq_EOC_Human1.30322120
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.30240862
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.30199380
65ER_23166858_ChIP-Seq_MCF-7_Human1.29933542
66* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29529884
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28875308
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28727459
69RXR_22108803_ChIP-Seq_LS180_Human1.28305678
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28126339
71* P53_22387025_ChIP-Seq_ESCs_Mouse1.24786514
72TCF4_23295773_ChIP-Seq_U87_Human1.24671659
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.24173912
74* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23757649
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.23670902
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22165592
77* CMYC_18555785_Chip-Seq_ESCs_Mouse1.20618664
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19794677
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19045567
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18087583
81* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17241042
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17117221
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16856245
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16755540
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.16429388
86* STAT3_18555785_Chip-Seq_ESCs_Mouse1.16014202
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15816550
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15603170
89BRD4_25478319_ChIP-Seq_HGPS_Human1.13727683
90* SOX2_18555785_Chip-Seq_ESCs_Mouse1.13666518
91* TP63_23658742_ChIP-Seq_EP156T_Human1.13257005
92SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12522854
93CJUN_26792858_Chip-Seq_BT549_Human1.12507339
94TCF4_22108803_ChIP-Seq_LS180_Human1.11878573
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11804192
96AR_25329375_ChIP-Seq_VCAP_Human1.11588480
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11457174
98ESR1_20079471_ChIP-ChIP_T-47D_Human1.10981981
99* NMYC_18555785_Chip-Seq_ESCs_Mouse1.09693954
100* P300_18555785_Chip-Seq_ESCs_Mouse1.09249564
101CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08944449
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08556414
103TCF4_18268006_ChIP-ChIP_LS174T_Human1.08278730
104CDX2_22108803_ChIP-Seq_LS180_Human1.07998342
105* ZFX_18555785_Chip-Seq_ESCs_Mouse1.07795844
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07684273
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.07649677
108* OCT4_18555785_Chip-Seq_ESCs_Mouse1.07236720
109BCAT_22108803_ChIP-Seq_LS180_Human1.06105313
110KDM2B_26808549_Chip-Seq_REH_Human1.04507604
111* PU1_27457419_Chip-Seq_LIVER_Mouse1.04319339
112* STAT3_23295773_ChIP-Seq_U87_Human1.04230672
113EWS_26573619_Chip-Seq_HEK293_Human1.03535283
114CBP_20019798_ChIP-Seq_JUKART_Human1.03251158
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03251158
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03130785
117RNF2_27304074_Chip-Seq_NSC_Mouse1.03113427
118FUS_26573619_Chip-Seq_HEK293_Human1.02912750
119ESR1_21235772_ChIP-Seq_MCF-7_Human1.01701069
120RUNX2_22187159_ChIP-Seq_PCA_Human1.01607039
121* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01556256
122* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00912126
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99695390
124CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99550413
125* KLF4_18555785_Chip-Seq_ESCs_Mouse0.99333943

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog6.44895758
2MP0003011_delayed_dark_adaptation6.39805503
3MP0005253_abnormal_eye_physiology4.54375346
4MP0006072_abnormal_retinal_apoptosis4.23542132
5MP0008789_abnormal_olfactory_epithelium3.93260629
6MP0005394_taste/olfaction_phenotype3.76523898
7MP0005499_abnormal_olfactory_system3.76523898
8MP0003950_abnormal_plasma_membrane3.58145662
9MP0001984_abnormal_olfaction2.84189231
10MP0005195_abnormal_posterior_eye2.67068140
11MP0001324_abnormal_eye_pigmentation2.55824768
12MP0010030_abnormal_orbit_morphology2.49032214
13MP0009780_abnormal_chondrocyte_physiolo2.36196973
14MP0003646_muscle_fatigue2.24904455
15MP0005391_vision/eye_phenotype2.24688695
16MP0002090_abnormal_vision2.14976273
17MP0002638_abnormal_pupillary_reflex2.09721540
18MP0009384_cardiac_valve_regurgitation2.01517219
19MP0002876_abnormal_thyroid_physiology1.92289338
20MP0008875_abnormal_xenobiotic_pharmacok1.85593630
21MP0005171_absent_coat_pigmentation1.85271008
22MP0000566_synostosis1.83424409
23MP0004130_abnormal_muscle_cell1.82535896
24MP0006054_spinal_hemorrhage1.81695422
25MP0000569_abnormal_digit_pigmentation1.76318005
26MP0002108_abnormal_muscle_morphology1.64405111
27MP0006292_abnormal_olfactory_placode1.63897012
28MP0008438_abnormal_cutaneous_collagen1.63384468
29MP0010386_abnormal_urinary_bladder1.57135063
30MP0001188_hyperpigmentation1.56242650
31MP0000427_abnormal_hair_cycle1.55594120
32MP0009697_abnormal_copulation1.55065448
33MP0001986_abnormal_taste_sensitivity1.53341758
34MP0002837_dystrophic_cardiac_calcinosis1.50940806
35MP0001346_abnormal_lacrimal_gland1.46967043
36MP0003878_abnormal_ear_physiology1.46172425
37MP0005377_hearing/vestibular/ear_phenot1.46172425
38MP0000372_irregular_coat_pigmentation1.43046495
39MP0002060_abnormal_skin_morphology1.42287070
40MP0000538_abnormal_urinary_bladder1.37995598
41MP0008775_abnormal_heart_ventricle1.35177484
42MP0002796_impaired_skin_barrier1.34784954
43MP0010368_abnormal_lymphatic_system1.33455543
44MP0004019_abnormal_vitamin_homeostasis1.33009245
45MP0002752_abnormal_somatic_nervous1.32624785
46MP0002160_abnormal_reproductive_system1.31224577
47MP0005197_abnormal_uvea_morphology1.31069205
48MP0001764_abnormal_homeostasis1.30475432
49MP0002233_abnormal_nose_morphology1.30090041
50MP0004782_abnormal_surfactant_physiolog1.29085374
51MP0000579_abnormal_nail_morphology1.26700907
52MP0005670_abnormal_white_adipose1.26618808
53MP0003279_aneurysm1.25521782
54MP0005503_abnormal_tendon_morphology1.25276035
55MP0000013_abnormal_adipose_tissue1.24447528
56MP0004145_abnormal_muscle_electrophysio1.23464145
57MP0002229_neurodegeneration1.23310535
58MP0002254_reproductive_system_inflammat1.23261448
59MP0000467_abnormal_esophagus_morphology1.22380929
60MP0004043_abnormal_pH_regulation1.21558944
61MP0000230_abnormal_systemic_arterial1.20383376
62MP0002896_abnormal_bone_mineralization1.18110967
63MP0009053_abnormal_anal_canal1.15533299
64MP0003283_abnormal_digestive_organ1.14619319
65MP0009250_abnormal_appendicular_skeleto1.14433963
66MP0003941_abnormal_skin_development1.13773751
67MP0005646_abnormal_pituitary_gland1.13191754
68MP0002277_abnormal_respiratory_mucosa1.12718078
69MP0001919_abnormal_reproductive_system1.11130467
70MP0001485_abnormal_pinna_reflex1.09657063
71MP0001502_abnormal_circadian_rhythm1.09585555
72MP0002282_abnormal_trachea_morphology1.05818857
73MP0010678_abnormal_skin_adnexa1.05601840
74MP0002115_abnormal_skeleton_extremities1.04796403
75MP0005248_abnormal_Harderian_gland1.04480756
76MP0000163_abnormal_cartilage_morphology1.03943996
77MP0001879_abnormal_lymphatic_vessel1.03775672
78MP0000534_abnormal_ureter_morphology1.03416741
79MP0000678_abnormal_parathyroid_gland1.03011139
80MP0005408_hypopigmentation1.01761229
81MP0005360_urolithiasis1.00737756
82MP0000049_abnormal_middle_ear1.00582959
83MP0005423_abnormal_somatic_nervous0.99619019
84MP0003195_calcinosis0.98146903
85MP0001958_emphysema0.98117472
86MP0002009_preneoplasia0.97767379
87MP0000762_abnormal_tongue_morphology0.97409615
88MP0000647_abnormal_sebaceous_gland0.97125234
89MP0001661_extended_life_span0.96551806
90MP0000026_abnormal_inner_ear0.92673766
91MP0001963_abnormal_hearing_physiology0.92605912
92MP0001756_abnormal_urination0.92053234
93MP0002249_abnormal_larynx_morphology0.91682147
94MP0004147_increased_porphyrin_level0.91148003
95MP0004215_abnormal_myocardial_fiber0.89149719
96MP0002938_white_spotting0.89024061
97MP0003136_yellow_coat_color0.88517651
98MP0004134_abnormal_chest_morphology0.88269220
99MP0010771_integument_phenotype0.88115751
100MP0001299_abnormal_eye_distance/0.87470181
101MP0005023_abnormal_wound_healing0.87434098
102MP0003252_abnormal_bile_duct0.86234267
103MP0002971_abnormal_brown_adipose0.86149460
104MP0008004_abnormal_stomach_pH0.85216099
105MP0000613_abnormal_salivary_gland0.85104715
106MP0003705_abnormal_hypodermis_morpholog0.83584102
107MP0000428_abnormal_craniofacial_morphol0.83507767
108MP0001486_abnormal_startle_reflex0.83368629
109MP0004381_abnormal_hair_follicle0.81842937
110MP0008872_abnormal_physiological_respon0.80284871
111MP0003755_abnormal_palate_morphology0.79875833
112MP0003045_fibrosis0.79627087
113MP0001501_abnormal_sleep_pattern0.79159886
114MP0004133_heterotaxia0.78515021
115MP0002109_abnormal_limb_morphology0.78462697
116MP0002127_abnormal_cardiovascular_syste0.77730696
117MP0005645_abnormal_hypothalamus_physiol0.76069104
118MP0008995_early_reproductive_senescence0.75510805
119MP0009046_muscle_twitch0.75349623
120MP0004084_abnormal_cardiac_muscle0.75072187
121MP0005595_abnormal_vascular_smooth0.75048542
122MP0001664_abnormal_digestion0.73803537
123MP0005389_reproductive_system_phenotype0.72711941
124MP0002998_abnormal_bone_remodeling0.72565140
125MP0003724_increased_susceptibility_to0.72505475
126MP0003942_abnormal_urinary_system0.72457317
127MP0002177_abnormal_outer_ear0.71651960
128MP0005620_abnormal_muscle_contractility0.71326158
129MP0003566_abnormal_cell_adhesion0.71228697
130MP0002098_abnormal_vibrissa_morphology0.71006152
131MP0004885_abnormal_endolymph0.70808859
132MP0000383_abnormal_hair_follicle0.70071040
133MP0005647_abnormal_sex_gland0.69498330
134MP0001286_abnormal_eye_development0.69353779
135MP0002932_abnormal_joint_morphology0.68801476
136MP0009764_decreased_sensitivity_to0.68356119
137MP0001270_distended_abdomen0.68305801
138MP0010329_abnormal_lipoprotein_level0.67814899
139MP0001177_atelectasis0.67768743
140MP0005508_abnormal_skeleton_morphology0.67483423
141MP0000751_myopathy0.67357375
142MP0004272_abnormal_basement_membrane0.66311097
143MP0002168_other_aberrant_phenotype0.65278812
144MP0002877_abnormal_melanocyte_morpholog0.65247061
145MP0000767_abnormal_smooth_muscle0.65149489
146MP0003879_abnormal_hair_cell0.64643369
147MP0009115_abnormal_fat_cell0.64576184
148MP0005257_abnormal_intraocular_pressure0.64408572
149MP0003937_abnormal_limbs/digits/tail_de0.63941691
150MP0002295_abnormal_pulmonary_circulatio0.62616091
151MP0005390_skeleton_phenotype0.61169815
152MP0002882_abnormal_neuron_morphology0.60949733
153MP0001542_abnormal_bone_strength0.60605247
154MP0004742_abnormal_vestibular_system0.59098017
155MP0002102_abnormal_ear_morphology0.58928113
156MP0003385_abnormal_body_wall0.57909615
157MP0003828_pulmonary_edema0.55914997
158MP0005275_abnormal_skin_tensile0.54498412
159MP0000015_abnormal_ear_pigmentation0.53947257

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)8.68522437
2Abnormal rod and cone electroretinograms (HP:0008323)7.07139763
3Pigmentary retinal degeneration (HP:0001146)7.00616125
4Chorioretinal atrophy (HP:0000533)6.99931221
5Absent rod-and cone-mediated responses on ERG (HP:0007688)6.81084338
6Central scotoma (HP:0000603)6.16175730
7Abnormality of macular pigmentation (HP:0008002)5.52739968
8Attenuation of retinal blood vessels (HP:0007843)5.51134169
9Dyschromatopsia (HP:0007641)5.48654457
10Scotoma (HP:0000575)5.24010461
11Decreased central vision (HP:0007663)4.96021586
12Pendular nystagmus (HP:0012043)4.94544504
13Abolished electroretinogram (ERG) (HP:0000550)4.94392411
14Keratoconus (HP:0000563)4.93950027
15Increased corneal curvature (HP:0100692)4.93950027
16Aortic aneurysm (HP:0004942)3.99534190
17Photophobia (HP:0000613)3.96297220
18Protrusio acetabuli (HP:0003179)3.94678583
19Cone-rod dystrophy (HP:0000548)3.93500276
20Aortic dissection (HP:0002647)3.86286964
21Potter facies (HP:0002009)3.74150785
22Facial shape deformation (HP:0011334)3.74150785
23Vitreoretinal degeneration (HP:0000655)3.68765364
24Severe visual impairment (HP:0001141)3.54449523
25Type II diabetes mellitus (HP:0005978)3.53370843
26Macular degeneration (HP:0000608)3.51581969
27Congenital sensorineural hearing impairment (HP:0008527)3.42870432
28Retinitis pigmentosa (HP:0000510)3.26484705
29Choroideremia (HP:0001139)3.11250132
30Atrophic scars (HP:0001075)2.99484914
31Constricted visual fields (HP:0001133)2.84227767
32Broad metatarsal (HP:0001783)2.82643882
33Soft skin (HP:0000977)2.80964478
34Abnormality of secondary sexual hair (HP:0009888)2.71037721
35Abnormality of the axillary hair (HP:0100134)2.71037721
36Metaphyseal dysplasia (HP:0100255)2.62017185
37Stomach cancer (HP:0012126)2.58486088
38Vascular tortuosity (HP:0004948)2.55114475
39True hermaphroditism (HP:0010459)2.53128140
40Chronic hepatic failure (HP:0100626)2.49071659
41Tubular atrophy (HP:0000092)2.47775241
42Lip pit (HP:0100267)2.43069113
43Progressive visual loss (HP:0000529)2.42665237
44Alopecia of scalp (HP:0002293)2.41783454
45Genetic anticipation (HP:0003743)2.37720337
46Bladder diverticulum (HP:0000015)2.37691087
47Decreased circulating renin level (HP:0003351)2.36977783
48Short hallux (HP:0010109)2.30573316
49Aplasia/Hypoplasia of the fovea (HP:0008060)2.29759234
50Hypoplasia of the fovea (HP:0007750)2.29759234
51Limited hip movement (HP:0008800)2.29584274
52Fragile skin (HP:0001030)2.28757349
53Mesomelia (HP:0003027)2.27718607
54Furrowed tongue (HP:0000221)2.26138660
55Redundant skin (HP:0001582)2.23106818
56Overgrowth (HP:0001548)2.23060742
57Gaze-evoked nystagmus (HP:0000640)2.21854043
58Pancreatic fibrosis (HP:0100732)2.21695008
59Neonatal short-limb short stature (HP:0008921)2.21510003
60Molar tooth sign on MRI (HP:0002419)2.20429695
61Abnormality of midbrain morphology (HP:0002418)2.20429695
62Retinal atrophy (HP:0001105)2.19769513
63Renal cortical cysts (HP:0000803)2.19487647
64Abnormality of the proximal phalanges of the hand (HP:0009834)2.18036784
65Medial flaring of the eyebrow (HP:0010747)2.17850725
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17639270
67Abnormality of the frontal sinuses (HP:0002687)2.15167010
68Hyperventilation (HP:0002883)2.14947077
69Aplasia/Hypoplasia of the hallux (HP:0008362)2.14943852
70Hypoplastic ischia (HP:0003175)2.12623247
71Metabolic alkalosis (HP:0200114)2.11175426
72Nephrogenic diabetes insipidus (HP:0009806)2.09169672
73Arterial tortuosity (HP:0005116)2.08969399
74Spondylolisthesis (HP:0003302)2.08522333
75Absent frontal sinuses (HP:0002688)2.08517875
76Prostate neoplasm (HP:0100787)2.06788756
77Hip contracture (HP:0003273)2.06351807
78Congenital primary aphakia (HP:0007707)2.03054949
79Wrist flexion contracture (HP:0001239)2.02564113
80Septo-optic dysplasia (HP:0100842)2.02488517
81Aplasia involving bones of the upper limbs (HP:0009823)2.01552026
82Aplasia of the phalanges of the hand (HP:0009802)2.01552026
83Aplasia involving bones of the extremities (HP:0009825)2.01552026
84Abnormality of incisor morphology (HP:0011063)2.01493140
85Osteomalacia (HP:0002749)2.00622707
86Congenital stationary night blindness (HP:0007642)10.5799772
87Aplasia/Hypoplasia of the tibia (HP:0005772)1.99888846
88Abnormality of the fovea (HP:0000493)1.98689718
89Pulmonary artery stenosis (HP:0004415)1.98266433
90Tubulointerstitial fibrosis (HP:0005576)1.97046447
91Gait imbalance (HP:0002141)1.96670018
92Hamartoma of the eye (HP:0010568)1.96362276
93Bulbous nose (HP:0000414)1.95489943
94Onycholysis (HP:0001806)1.94856810
95Type II lissencephaly (HP:0007260)1.94095269
96Ankle contracture (HP:0006466)1.91619012
97Coronal craniosynostosis (HP:0004440)1.90080242
98Adactyly (HP:0009776)1.89924354
99Hydroxyprolinuria (HP:0003080)1.89403681
100Abnormality of proline metabolism (HP:0010907)1.89403681
101Cervical subluxation (HP:0003308)1.89354067
102Submucous cleft hard palate (HP:0000176)1.86792213
103Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.85658946
104Tarsal synostosis (HP:0008368)1.85489400
105Palmoplantar hyperkeratosis (HP:0000972)1.84940161
106Plantar hyperkeratosis (HP:0007556)1.84927690
107Aortic regurgitation (HP:0001659)1.84426139
108Abnormality of the ischium (HP:0003174)1.84293609
109Abnormality of the renal collecting system (HP:0004742)1.82481117
110Infantile muscular hypotonia (HP:0008947)1.82412997
111Bone cyst (HP:0012062)1.81744650
112Congenital, generalized hypertrichosis (HP:0004540)1.81381108
113Tubulointerstitial nephritis (HP:0001970)1.79508191
114Broad ribs (HP:0000885)1.79004480
115Fragile nails (HP:0001808)1.76918781
116Wide anterior fontanel (HP:0000260)1.74633572
117Woolly hair (HP:0002224)1.74427813
118Palmar hyperkeratosis (HP:0010765)1.73653091
119Posterior subcapsular cataract (HP:0007787)1.73190585
120Poor coordination (HP:0002370)1.72005020
121Preauricular pit (HP:0004467)1.71416989
122Periauricular skin pits (HP:0100277)1.71416989
123Anterior segment dysgenesis (HP:0007700)1.71375755
124Alveolar cell carcinoma (HP:0006519)1.71199297
125Aortic valve stenosis (HP:0001650)1.71129055
126Progressive cerebellar ataxia (HP:0002073)1.69561240
127Synostosis of carpal bones (HP:0005048)1.69271286
128Premature rupture of membranes (HP:0001788)1.68957853
129Synostosis involving bones of the feet (HP:0009140)1.68461837
130Synostosis involving bones of the lower limbs (HP:0009138)1.68461837
131Corneal erosion (HP:0200020)1.68421032
132Abnormality of nail color (HP:0100643)1.68315731
133Febrile seizures (HP:0002373)1.66466971
134Aplasia/Hypoplasia of the tongue (HP:0010295)1.66358029
135Aplasia/Hypoplasia of the lens (HP:0008063)1.64652719
136Abnormality of the phalanges of the 2nd finger (HP:0009541)1.63125871
137Pancreatic cysts (HP:0001737)1.62261619
138Vaginal atresia (HP:0000148)1.62258890
139Fibular aplasia (HP:0002990)1.61130375
140Abnormality of the middle phalanges of the toes (HP:0010183)1.60863531
141Abnormality of the renal medulla (HP:0100957)1.60662787
142Follicular hyperkeratosis (HP:0007502)1.60637651
143Vascular calcification (HP:0004934)1.58893568
144Atrial fibrillation (HP:0005110)1.58636966
145Neoplasm of the tracheobronchial system (HP:0100552)1.56588994
146Cardiovascular calcification (HP:0011915)1.56505501
147Cystic liver disease (HP:0006706)1.55884594
148Subcapsular cataract (HP:0000523)1.55650385
149Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.54760374
150Genital tract atresia (HP:0001827)1.54610477
151Congenital hepatic fibrosis (HP:0002612)1.54102888
152Morphological abnormality of the middle ear (HP:0008609)1.52674260
153Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.51895661
154Optic disc pallor (HP:0000543)1.50533064
155Syncope (HP:0001279)1.49035844
156Absent eyebrow (HP:0002223)1.48436599
157Aplasia/Hypoplasia of the macula (HP:0008059)1.48264299
158Renal tubular acidosis (HP:0001947)1.47948576
159Corneal dystrophy (HP:0001131)1.47585363
160Abnormality of the renal cortex (HP:0011035)1.47348941
161Wide nasal bridge (HP:0000431)1.47324770
162Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.44363176
163Urethral obstruction (HP:0000796)1.44353534
164Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.44068270
165Abnormality of the phalanges of the 5th finger (HP:0004213)1.43188399
166Astigmatism (HP:0000483)1.42280260
167Abnormality of the nasal septum (HP:0000419)1.41585987
168Renal dysplasia (HP:0000110)1.41299643
169Nephronophthisis (HP:0000090)1.40989989
170Distal lower limb muscle weakness (HP:0009053)1.39992274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK14.62331773
2CASK3.41723458
3INSRR2.89703548
4ZAK2.80251196
5NUAK12.65930663
6PBK2.63863800
7SIK32.23557361
8PRPF4B2.22728356
9STK38L2.14165139
10MAPKAPK31.98484301
11ACVR1B1.96988192
12MYLK1.94156172
13TGFBR11.85110914
14WNK31.82274593
15ERBB31.80651192
16SGK21.80410276
17BMPR1B1.76306999
18PINK11.75442536
19LATS11.72382857
20EPHA31.70002253
21BMPR21.68527927
22AKT31.66303801
23MAP3K141.66010839
24TIE11.63510947
25ADRBK21.55663932
26SGK4941.48570205
27SGK2231.48570205
28MAP2K71.39465900
29YES11.35203225
30NTRK11.34651060
31MET1.32308476
32TXK1.30150556
33MAPK71.29391630
34NEK61.27127575
35MAP4K21.20539317
36MKNK21.14812606
37SGK31.13766634
38CDK31.12514755
39PDGFRA1.09394445
40MAPKAPK51.07903022
41PDGFRB1.05790875
42OBSCN1.03659234
43IRAK21.03572024
44TRPM71.03025953
45KIT0.98428513
46TNIK0.98285126
47FRK0.95826214
48FGFR20.95680615
49PRKCE0.95641145
50FLT30.94956778
51TNK20.93742844
52CSNK1A1L0.92541689
53SIK10.92252405
54MAP3K60.91559291
55PTK2B0.91451187
56PTK20.91047768
57EPHB20.86723990
58PIK3CA0.85897783
59PKN10.84660266
60RPS6KA20.84562030
61TEC0.83174032
62MAPK150.82312543
63TAOK20.81726987
64TGFBR20.81432521
65PAK20.81357464
66PDK20.79688001
67NEK90.78669846
68STK390.77405760
69HIPK20.76521807
70LMTK20.75504616
71FER0.75394330
72CDC42BPA0.74296541
73MAP3K40.73462139
74CAMK1D0.71933686
75WNK10.71560750
76IKBKE0.71382977
77MAP2K10.70360644
78EIF2AK20.69278910
79NLK0.67739720
80ABL20.66580754
81CAMK1G0.66344827
82MAP3K30.65789881
83JAK10.65224949
84OXSR10.65016055
85PRKAA20.64338502
86PAK30.63864690
87CAMK40.63255786
88IKBKB0.63004196
89BCR0.62648332
90NTRK30.61442332
91PRKAA10.59602535
92DDR20.59475032
93TAOK30.59352523
94IRAK10.59275023
95NTRK20.58094406
96CHUK0.58040534
97SIK20.57064774
98CAMK2D0.56015807
99DAPK20.55690633
100ROCK10.55569305
101CAMK10.55274778
102MAPK130.54567457
103ADRBK10.53944075
104STK30.53128144
105TAF10.51646067
106ERBB20.51556630
107GSK3A0.50368587
108PRKG20.49991626
109PLK20.49825982
110GRK50.49560617
111MUSK0.49263102
112MELK0.48858710
113RPS6KA60.48834582
114DYRK1A0.48647499
115PHKG10.48175042
116PHKG20.48175042
117IGF1R0.47990668
118EPHA40.47792303
119PRKCH0.47546783
120PRKCG0.47077196
121MAPK120.47076038
122IRAK40.46797826
123SGK10.45799400
124CDK90.44912094
125STK110.44644378
126STK240.43411978
127MAP3K70.43361649
128ABL10.42603605
129MST1R0.42279002
130CAMK2A0.42093765
131CSNK1G10.41551732
132EPHA20.40868123
133ERBB40.40221216
134PRKD20.40151511
135PRKACA0.39356580
136LIMK10.39033084
137MKNK10.38731972
138STK380.38460588
139DMPK0.37738556
140MAP3K20.37478029
141PIK3CG0.37280998
142WNK40.37202917
143PRKG10.35902635
144BRD40.34984084

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose and glucuronate interconversions_Homo sapiens_hsa000403.08682345
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.04167061
3Steroid hormone biosynthesis_Homo sapiens_hsa001402.64922020
4Retinol metabolism_Homo sapiens_hsa008302.63401486
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.31296299
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.28344041
7Chemical carcinogenesis_Homo sapiens_hsa052042.09019104
8Phototransduction_Homo sapiens_hsa0474410.6202239
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.83942272
10Glycerolipid metabolism_Homo sapiens_hsa005611.67957619
11Starch and sucrose metabolism_Homo sapiens_hsa005001.61524932
12ABC transporters_Homo sapiens_hsa020101.60902532
13Tryptophan metabolism_Homo sapiens_hsa003801.57265684
14Fatty acid biosynthesis_Homo sapiens_hsa000611.56516821
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54799088
16Caffeine metabolism_Homo sapiens_hsa002321.53471213
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.40207980
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.39139035
19Nitrogen metabolism_Homo sapiens_hsa009101.38685448
20Circadian rhythm_Homo sapiens_hsa047101.29386676
21Ether lipid metabolism_Homo sapiens_hsa005651.27691288
22Fat digestion and absorption_Homo sapiens_hsa049751.22489027
23Dorso-ventral axis formation_Homo sapiens_hsa043201.18020444
24ECM-receptor interaction_Homo sapiens_hsa045121.10576782
25Salivary secretion_Homo sapiens_hsa049701.10058078
26Fatty acid degradation_Homo sapiens_hsa000711.05102087
27Propanoate metabolism_Homo sapiens_hsa006401.04408193
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03596108
29Mineral absorption_Homo sapiens_hsa049781.01354309
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99307336
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98965765
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96535931
33Rheumatoid arthritis_Homo sapiens_hsa053230.94615771
34Renin-angiotensin system_Homo sapiens_hsa046140.93925965
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91989699
36Olfactory transduction_Homo sapiens_hsa047400.91643859
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89648650
38Hedgehog signaling pathway_Homo sapiens_hsa043400.89346006
39Butanoate metabolism_Homo sapiens_hsa006500.89243854
40Fatty acid elongation_Homo sapiens_hsa000620.86260350
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86009684
42Synaptic vesicle cycle_Homo sapiens_hsa047210.81644990
43Gastric acid secretion_Homo sapiens_hsa049710.81146480
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80116350
45Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77546949
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75566010
47Vitamin digestion and absorption_Homo sapiens_hsa049770.73086882
48Arachidonic acid metabolism_Homo sapiens_hsa005900.72560397
49Dilated cardiomyopathy_Homo sapiens_hsa054140.72545326
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.72333398
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70839034
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70165523
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69424275
54Thyroid hormone synthesis_Homo sapiens_hsa049180.67861071
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66128593
56Pancreatic secretion_Homo sapiens_hsa049720.66048785
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65972060
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.65838513
59Tyrosine metabolism_Homo sapiens_hsa003500.65055113
60Fatty acid metabolism_Homo sapiens_hsa012120.64623680
61Oxytocin signaling pathway_Homo sapiens_hsa049210.64475871
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.64397494
63Ovarian steroidogenesis_Homo sapiens_hsa049130.63174950
64Morphine addiction_Homo sapiens_hsa050320.62699963
65Melanoma_Homo sapiens_hsa052180.62586015
66Sulfur metabolism_Homo sapiens_hsa009200.62347417
67Nicotine addiction_Homo sapiens_hsa050330.61590858
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58860008
69Complement and coagulation cascades_Homo sapiens_hsa046100.58817616
70Serotonergic synapse_Homo sapiens_hsa047260.58698445
71Notch signaling pathway_Homo sapiens_hsa043300.58565096
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.58289425
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.57769969
74Amoebiasis_Homo sapiens_hsa051460.57671690
75Cholinergic synapse_Homo sapiens_hsa047250.57568832
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56853026
77Malaria_Homo sapiens_hsa051440.55830361
78GABAergic synapse_Homo sapiens_hsa047270.54577327
79Long-term depression_Homo sapiens_hsa047300.53343269
80Insulin resistance_Homo sapiens_hsa049310.53179091
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53021945
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52704355
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52692640
84TNF signaling pathway_Homo sapiens_hsa046680.52249231
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49616286
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49448429
87Phenylalanine metabolism_Homo sapiens_hsa003600.49078538
88Selenocompound metabolism_Homo sapiens_hsa004500.49004369
89Axon guidance_Homo sapiens_hsa043600.47250498
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47228837
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.46599334
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46104625
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45961806
94Graft-versus-host disease_Homo sapiens_hsa053320.44917862
95beta-Alanine metabolism_Homo sapiens_hsa004100.44288719
96Linoleic acid metabolism_Homo sapiens_hsa005910.43747990
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43456171
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42889402
99Peroxisome_Homo sapiens_hsa041460.42872130
100Protein digestion and absorption_Homo sapiens_hsa049740.42082504
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41700716
102African trypanosomiasis_Homo sapiens_hsa051430.41594251
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.40113715
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39947941
105Circadian entrainment_Homo sapiens_hsa047130.39667762
106Glutathione metabolism_Homo sapiens_hsa004800.39034752
107Focal adhesion_Homo sapiens_hsa045100.37676932
108Staphylococcus aureus infection_Homo sapiens_hsa051500.37391074
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36688379
110Renin secretion_Homo sapiens_hsa049240.33797846
111Ras signaling pathway_Homo sapiens_hsa040140.33147400
112TGF-beta signaling pathway_Homo sapiens_hsa043500.32461800
113Adherens junction_Homo sapiens_hsa045200.32364874
114Histidine metabolism_Homo sapiens_hsa003400.31558833
115Taste transduction_Homo sapiens_hsa047420.29918222
116Glutamatergic synapse_Homo sapiens_hsa047240.29629367
117Insulin secretion_Homo sapiens_hsa049110.29552996
118Collecting duct acid secretion_Homo sapiens_hsa049660.29464768
119cAMP signaling pathway_Homo sapiens_hsa040240.27764481
120Prostate cancer_Homo sapiens_hsa052150.27422435
121Lysine degradation_Homo sapiens_hsa003100.27388040
122* Phagosome_Homo sapiens_hsa041450.27072014
123Hippo signaling pathway_Homo sapiens_hsa043900.26788734
124Sphingolipid metabolism_Homo sapiens_hsa006000.26759558
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26684706
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26380296
127Steroid biosynthesis_Homo sapiens_hsa001000.26318432
128Basal cell carcinoma_Homo sapiens_hsa052170.25714820
129Calcium signaling pathway_Homo sapiens_hsa040200.25268527
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25144466
131Autoimmune thyroid disease_Homo sapiens_hsa053200.24682490
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24091788
133Inositol phosphate metabolism_Homo sapiens_hsa005620.23681611
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22701709
135Pathways in cancer_Homo sapiens_hsa052000.21792900
136Influenza A_Homo sapiens_hsa051640.21512140
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21402140
138PPAR signaling pathway_Homo sapiens_hsa033200.21233886

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