PLA2G12A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.52241253
2DNA deamination (GO:0045006)5.41330418
3viral transcription (GO:0019083)5.40111908
4ribosomal small subunit assembly (GO:0000028)5.37202084
5translational termination (GO:0006415)5.30052637
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.99872406
7heme biosynthetic process (GO:0006783)4.98263933
8protein targeting to ER (GO:0045047)4.88126936
9cotranslational protein targeting to membrane (GO:0006613)4.85337249
10translational elongation (GO:0006414)4.82379446
11establishment of protein localization to endoplasmic reticulum (GO:0072599)4.67092252
12protein localization to endoplasmic reticulum (GO:0070972)4.61590158
13protoporphyrinogen IX metabolic process (GO:0046501)4.46300525
14regulation of mitochondrial translation (GO:0070129)4.33701516
15folic acid-containing compound biosynthetic process (GO:0009396)4.29481613
16translational initiation (GO:0006413)4.25530697
17porphyrin-containing compound biosynthetic process (GO:0006779)4.20608861
18blood coagulation, intrinsic pathway (GO:0007597)4.20143604
19negative regulation of heart rate (GO:0010459)4.19877420
20heme metabolic process (GO:0042168)4.19344814
21ribosomal small subunit biogenesis (GO:0042274)4.19013534
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.09466377
23lysine catabolic process (GO:0006554)4.05482186
24lysine metabolic process (GO:0006553)4.05482186
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.04975032
26maturation of SSU-rRNA (GO:0030490)4.02766317
27protoporphyrinogen IX biosynthetic process (GO:0006782)4.01989661
28valine metabolic process (GO:0006573)4.00415582
29viral life cycle (GO:0019058)4.00056976
30positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.95806952
31cellular protein complex disassembly (GO:0043624)3.95067114
32oxidative phosphorylation (GO:0006119)3.90727279
33thrombin receptor signaling pathway (GO:0070493)3.84780917
34tetrapyrrole biosynthetic process (GO:0033014)3.84042394
35ribosomal large subunit biogenesis (GO:0042273)3.82682857
36negative regulation of appetite (GO:0032099)3.82167648
37negative regulation of response to food (GO:0032096)3.82167648
38protein autoprocessing (GO:0016540)3.79844137
39translation (GO:0006412)3.74770081
40porphyrin-containing compound metabolic process (GO:0006778)3.61540790
41dopamine transport (GO:0015872)3.60926958
42ATP synthesis coupled proton transport (GO:0015986)3.59793656
43energy coupled proton transport, down electrochemical gradient (GO:0015985)3.59793656
44regulation of lipoprotein metabolic process (GO:0050746)3.58263162
45negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.53281533
46pteridine-containing compound biosynthetic process (GO:0042559)3.49774659
47regulation of female receptivity (GO:0045924)3.48062230
48deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.47301043
49pseudouridine synthesis (GO:0001522)3.47019818
50negative regulation of protein localization to cell surface (GO:2000009)3.46919292
51formation of translation preinitiation complex (GO:0001731)3.45211780
52regulation of integrin-mediated signaling pathway (GO:2001044)3.40950556
53protein complex disassembly (GO:0043241)3.38072574
54respiratory electron transport chain (GO:0022904)3.36567728
55proteasome assembly (GO:0043248)3.34323371
56ribonucleoprotein complex biogenesis (GO:0022613)3.30091443
57electron transport chain (GO:0022900)3.29659681
58cellular ketone body metabolic process (GO:0046950)3.27151268
59pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.25617168
60purine nucleotide salvage (GO:0032261)3.23717237
61protein targeting to membrane (GO:0006612)3.23528014
62mitochondrial respiratory chain complex I assembly (GO:0032981)3.22105853
63NADH dehydrogenase complex assembly (GO:0010257)3.22105853
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.22105853
65oxaloacetate metabolic process (GO:0006107)3.21298725
66macromolecular complex disassembly (GO:0032984)3.20190723
67folic acid metabolic process (GO:0046655)3.18939291
68negative regulation of norepinephrine secretion (GO:0010700)3.14182114
69triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.12882300
70tricarboxylic acid cycle (GO:0006099)3.10815948
71cysteine metabolic process (GO:0006534)3.09355011
72mitochondrial calcium ion transport (GO:0006851)3.08627704
73NADH metabolic process (GO:0006734)3.06337208
74ubiquinone biosynthetic process (GO:0006744)3.05313018
75quinone biosynthetic process (GO:1901663)3.05313018
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.05129536
77protein complex biogenesis (GO:0070271)3.05040056
78DNA replication initiation (GO:0006270)3.04931477
79DNA strand elongation involved in DNA replication (GO:0006271)3.04714471
80IMP biosynthetic process (GO:0006188)3.04516898
81pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.03944715
82regulation of cAMP-dependent protein kinase activity (GO:2000479)2.98286776
83aspartate family amino acid catabolic process (GO:0009068)2.97588352
84proline biosynthetic process (GO:0006561)2.97049789
85nuclear-transcribed mRNA catabolic process (GO:0000956)2.95552218
86telomere maintenance via semi-conservative replication (GO:0032201)2.94494612
87cellular component biogenesis (GO:0044085)2.93963285
88IMP metabolic process (GO:0046040)2.93417355
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.93160504
90L-phenylalanine catabolic process (GO:0006559)2.93160504
912-oxoglutarate metabolic process (GO:0006103)2.92833171
92behavioral response to nicotine (GO:0035095)2.90496819
93regulation of Golgi to plasma membrane protein transport (GO:0042996)2.89070915
94phospholipid homeostasis (GO:0055091)2.88800397
95deoxyribose phosphate biosynthetic process (GO:0046385)2.88384214
962-deoxyribonucleotide biosynthetic process (GO:0009265)2.88384214
97ketone body metabolic process (GO:1902224)2.88376161
98ribosome biogenesis (GO:0042254)2.86358478
99iron-sulfur cluster assembly (GO:0016226)2.84797287
100metallo-sulfur cluster assembly (GO:0031163)2.84797287
101pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.84727524
102DNA strand elongation (GO:0022616)2.84611082
103L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84153814
104nucleotide salvage (GO:0043173)2.83199548
105negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.81523564
106mRNA catabolic process (GO:0006402)2.80987470
107female mating behavior (GO:0060180)2.78315418
108muscle filament sliding (GO:0030049)2.73923036
109actin-myosin filament sliding (GO:0033275)2.73923036
110DNA replication checkpoint (GO:0000076)2.71538520
111tetrapyrrole metabolic process (GO:0033013)2.70998127
112positive regulation of cAMP-mediated signaling (GO:0043950)2.69998703
113regulation of sequestering of triglyceride (GO:0010889)2.69427678
114RNA catabolic process (GO:0006401)2.69424979
115xenobiotic catabolic process (GO:0042178)2.68847345
116relaxation of smooth muscle (GO:0044557)2.67103940
117positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.67046993
118platelet dense granule organization (GO:0060155)2.66804873
119fatty acid elongation (GO:0030497)2.65949142
120AMP metabolic process (GO:0046033)2.65675760
121positive regulation of endothelial cell differentiation (GO:0045603)2.64206684
122neuronal action potential propagation (GO:0019227)2.64099305
123regulation of skeletal muscle contraction (GO:0014819)2.61660919
124negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.61188912
125negative regulation of calcium ion transmembrane transport (GO:1903170)2.61188912
126methionine biosynthetic process (GO:0009086)2.59985775
127pigment biosynthetic process (GO:0046148)2.59969867
128mitochondrial calcium ion homeostasis (GO:0051560)2.59430416
129cellular biogenic amine catabolic process (GO:0042402)2.59221290
130amine catabolic process (GO:0009310)2.59221290
131galactose catabolic process (GO:0019388)2.59196908
132negative regulation of heart contraction (GO:0045822)2.58818106
133ether lipid metabolic process (GO:0046485)2.58712487
134fusion of sperm to egg plasma membrane (GO:0007342)2.57435116
135branched-chain amino acid metabolic process (GO:0009081)2.56705161
136membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.56626620
137rRNA processing (GO:0006364)2.56415773
138regulation of response to food (GO:0032095)2.56200241
139cardiolipin metabolic process (GO:0032048)2.55401079
140positive regulation of protein homodimerization activity (GO:0090073)2.55290978
141mitochondrial respiratory chain complex assembly (GO:0033108)2.54037978
142purine-containing compound salvage (GO:0043101)2.54001980
143tricarboxylic acid metabolic process (GO:0072350)2.53705850
144glycine metabolic process (GO:0006544)2.53434642
145nucleobase biosynthetic process (GO:0046112)2.53281785
146tyrosine metabolic process (GO:0006570)2.53075930
147calcium ion import (GO:0070509)2.52491353
148regulation of acyl-CoA biosynthetic process (GO:0050812)2.51779741
149L-methionine salvage (GO:0071267)2.51588506
150L-methionine biosynthetic process (GO:0071265)2.51588506
151amino acid salvage (GO:0043102)2.51588506
152aspartate family amino acid metabolic process (GO:0009066)2.51545391
153tRNA aminoacylation for protein translation (GO:0006418)2.51368827
154nucleoside monophosphate biosynthetic process (GO:0009124)2.51329204
155positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.50851655
156positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.50736032
157UMP metabolic process (GO:0046049)2.50625615
158UMP biosynthetic process (GO:0006222)2.50625615
159erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.48514216
160L-phenylalanine metabolic process (GO:0006558)2.48514216
161relaxation of muscle (GO:0090075)2.46259824
162ubiquinone metabolic process (GO:0006743)2.43174386
163peroxisome fission (GO:0016559)2.42477915
164water-soluble vitamin biosynthetic process (GO:0042364)2.37636199
165autophagic vacuole fusion (GO:0000046)2.36672621
166aromatic amino acid family catabolic process (GO:0009074)2.35850480
167regulation of appetite (GO:0032098)2.35574348
168negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.34884001
169response to nitrosative stress (GO:0051409)2.34144306
170sulfation (GO:0051923)2.33418124
171regulation of oxidative phosphorylation (GO:0002082)2.33167784
172beta-amyloid metabolic process (GO:0050435)2.32547355
173negative regulation of thymocyte apoptotic process (GO:0070244)2.31055612
174positive regulation of glycolytic process (GO:0045821)2.30236441
175S-adenosylmethionine metabolic process (GO:0046500)2.29867523
176fatty acid transmembrane transport (GO:1902001)2.26230779
177regulation of platelet activation (GO:0010543)2.26184473
178regulation of macrophage derived foam cell differentiation (GO:0010743)2.24875307
179polyamine metabolic process (GO:0006595)2.24159678
180benzene-containing compound metabolic process (GO:0042537)2.23186924
181pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.21372672
182positive regulation of cardiac muscle hypertrophy (GO:0010613)2.20669857
183positive regulation of muscle hypertrophy (GO:0014742)2.20669857
184methionine metabolic process (GO:0006555)2.19693136
185negative regulation of platelet activation (GO:0010544)2.19513675
186regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.19500683
187detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.19013861

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.89067794
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.82934951
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.06719007
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.65528460
5GBX2_23144817_ChIP-Seq_PC3_Human3.58717410
6EZH2_22144423_ChIP-Seq_EOC_Human3.51314651
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.34603682
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.15176081
9VDR_22108803_ChIP-Seq_LS180_Human3.02007394
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.99702800
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.89919018
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89369701
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.88424409
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.85476040
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78141101
16IGF1R_20145208_ChIP-Seq_DFB_Human2.75224544
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.57831879
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50148938
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44190416
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.42612083
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36399444
22TAF15_26573619_Chip-Seq_HEK293_Human2.30516411
23DCP1A_22483619_ChIP-Seq_HELA_Human2.21000549
24HTT_18923047_ChIP-ChIP_STHdh_Human2.13990324
25* EWS_26573619_Chip-Seq_HEK293_Human2.13862819
26XRN2_22483619_ChIP-Seq_HELA_Human2.08135587
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08083854
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07379785
29VDR_23849224_ChIP-Seq_CD4+_Human2.06226023
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05506352
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04989686
32GABP_19822575_ChIP-Seq_HepG2_Human1.95832852
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.94335078
34FUS_26573619_Chip-Seq_HEK293_Human1.92540117
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92517876
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90234419
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89752553
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.87918911
39ER_23166858_ChIP-Seq_MCF-7_Human1.86520609
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.84604475
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84362200
42FOXP3_21729870_ChIP-Seq_TREG_Human1.83634691
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82933013
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82510727
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81837185
46* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.81044816
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80367334
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80235203
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.79927769
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.79351228
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78853464
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77918653
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77006774
54MYC_22102868_ChIP-Seq_BL_Human1.76987331
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.76698040
56SMAD4_21799915_ChIP-Seq_A2780_Human1.73913475
57* RXR_22158963_ChIP-Seq_LIVER_Mouse1.72722461
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70049108
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.68723294
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67526894
61P300_19829295_ChIP-Seq_ESCs_Human1.65167230
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64394586
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63374332
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62750617
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61574672
66TTF2_22483619_ChIP-Seq_HELA_Human1.61476739
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59752079
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59640355
69ZNF274_21170338_ChIP-Seq_K562_Hela1.58590622
70RNF2_27304074_Chip-Seq_NSC_Mouse1.57641683
71* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55073370
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53631541
73ZNF263_19887448_ChIP-Seq_K562_Human1.53257375
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52386693
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51998204
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51059798
77STAT3_23295773_ChIP-Seq_U87_Human1.50832945
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50767922
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49814171
80FOXM1_23109430_ChIP-Seq_U2OS_Human1.49408574
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49045435
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48952400
83GATA1_22025678_ChIP-Seq_K562_Human1.48356636
84IRF1_19129219_ChIP-ChIP_H3396_Human1.48131726
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46129275
86AR_25329375_ChIP-Seq_VCAP_Human1.45771320
87AR_21909140_ChIP-Seq_LNCAP_Human1.45468059
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45011199
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.44245102
90KDM5A_27292631_Chip-Seq_BREAST_Human1.43078387
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42895990
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42833170
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42451591
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42193539
95TCF4_23295773_ChIP-Seq_U87_Human1.41538033
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.39228068
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38802046
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37950789
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.36245524
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34992157
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34740779
102* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34145637
103TP53_22573176_ChIP-Seq_HFKS_Human1.32807878
104NANOG_19829295_ChIP-Seq_ESCs_Human1.31996854
105SOX2_19829295_ChIP-Seq_ESCs_Human1.31996854
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31755385
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31016221
108CIITA_25753668_ChIP-Seq_RAJI_Human1.30553858
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29667937
110BCAT_22108803_ChIP-Seq_LS180_Human1.27177359
111NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27166483
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27166483
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25657901
114P53_22387025_ChIP-Seq_ESCs_Mouse1.25218923
115HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25155860
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25098148
117BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24550707
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23480595
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23058591
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.22902507
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22574175
122VDR_21846776_ChIP-Seq_THP-1_Human1.21787752
123FOXA1_25329375_ChIP-Seq_VCAP_Human1.20789518
124FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20789518
125ESR1_20079471_ChIP-ChIP_T-47D_Human1.19604753
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18977312
127FLI1_21867929_ChIP-Seq_TH2_Mouse1.18707041
128TAL1_26923725_Chip-Seq_HPCs_Mouse1.17451065
129POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16902334
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16883789
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16269148
132ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12763858
133FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12458944
134GATA3_21878914_ChIP-Seq_MCF-7_Human1.12126442
135NFE2_27457419_Chip-Seq_LIVER_Mouse1.11510971
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09631840
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09360014
138TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09263326
139KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09201621
140KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08960160
141CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08804936
142NANOG_18555785_Chip-Seq_ESCs_Mouse1.08729521
143E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06483590
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06050122
145NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05537428
146AR_20517297_ChIP-Seq_VCAP_Human1.05337844
147JUN_21703547_ChIP-Seq_K562_Human1.05215789
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05086640
149PHF8_20622853_ChIP-Seq_HELA_Human1.04825946
150RBPJ_21746931_ChIP-Seq_IB4_Human1.04759841
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04520826
152TCF4_22108803_ChIP-Seq_LS180_Human1.04225886
153* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04221810
154FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03582694
155ELK1_19687146_ChIP-ChIP_HELA_Human1.03241744
156SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02938832
157TFEB_21752829_ChIP-Seq_HELA_Human1.02753790
158OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02352478
159GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02262112
160CDX2_22108803_ChIP-Seq_LS180_Human1.02228656
161TBL1_22424771_ChIP-Seq_293T_Human1.02119472
162E2F1_18555785_Chip-Seq_ESCs_Mouse1.01924329
163IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01782308
164CBP_20019798_ChIP-Seq_JUKART_Human1.01782308
165NFYB_21822215_ChIP-Seq_K562_Human1.01416171
166NOTCH1_21737748_ChIP-Seq_TLL_Human1.01381355
167TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01235302
168* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01030228
169CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00657259
170STAT3_18555785_Chip-Seq_ESCs_Mouse1.00072738
171CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99859380
172ETV1_20927104_ChIP-Seq_GIST48_Human0.99505791
173NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99410438
174HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99189989
175RUNX2_22187159_ChIP-Seq_PCA_Human0.98880252
176* LXR_22158963_ChIP-Seq_LIVER_Mouse0.98857644
177FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98026091
178SOX2_21211035_ChIP-Seq_LN229_Gbm0.97074087
179GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96377289
180MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95595520
181MYC_18940864_ChIP-ChIP_HL60_Human0.95392193
182GATA2_19941826_ChIP-Seq_K562_Human0.95187572
183OCT1_27270436_Chip-Seq_PROSTATE_Human0.94865004
184TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94324422
185SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93562380
186EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93331313
187ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92715978
188YY1_22570637_ChIP-Seq_MALME-3M_Human0.92562252
189SCL_19346495_ChIP-Seq_HPC-7_Human0.91996027
190GATA1_19941827_ChIP-Seq_MEL_Mouse0.90978265
191FOXP1_21924763_ChIP-Seq_HESCs_Human0.90741567
192ATF3_27146783_Chip-Seq_COLON_Human0.90576141
193* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88537855
194SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88264776
195YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87772798

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo4.65765515
2MP0005464_abnormal_platelet_physiology3.89088167
3MP0006054_spinal_hemorrhage3.88222039
4MP0003806_abnormal_nucleotide_metabolis3.76351264
5MP0004147_increased_porphyrin_level3.63141416
6MP0002139_abnormal_hepatobiliary_system3.20531200
7MP0006036_abnormal_mitochondrial_physio3.07088843
8MP0003646_muscle_fatigue2.97514626
9MP0003693_abnormal_embryo_hatching2.92016512
10MP0005646_abnormal_pituitary_gland2.85964478
11MP0003186_abnormal_redox_activity2.55553603
12MP0002837_dystrophic_cardiac_calcinosis2.49193218
13MP0002736_abnormal_nociception_after2.42449662
14MP0000749_muscle_degeneration2.33504800
15MP0008872_abnormal_physiological_respon2.28635229
16MP0008004_abnormal_stomach_pH2.27013003
17MP0009780_abnormal_chondrocyte_physiolo2.24428926
18MP0004957_abnormal_blastocyst_morpholog2.20339654
19MP0001968_abnormal_touch/_nociception2.20150677
20MP0005085_abnormal_gallbladder_physiolo2.17161878
21MP0003011_delayed_dark_adaptation2.11227147
22MP0004130_abnormal_muscle_cell2.05664257
23MP0005365_abnormal_bile_salt2.04261251
24MP0004145_abnormal_muscle_electrophysio1.88911710
25MP0000747_muscle_weakness1.88105290
26MP0006276_abnormal_autonomic_nervous1.87909676
27MP0004043_abnormal_pH_regulation1.85686918
28MP0005670_abnormal_white_adipose1.83459740
29MP0005360_urolithiasis1.83197412
30MP0002160_abnormal_reproductive_system1.81311458
31MP0004215_abnormal_myocardial_fiber1.78711686
32MP0000230_abnormal_systemic_arterial1.77789119
33MP0001661_extended_life_span1.77563799
34MP0000751_myopathy1.72999155
35MP0002876_abnormal_thyroid_physiology1.71612823
36MP0000372_irregular_coat_pigmentation1.71355935
37MP0005083_abnormal_biliary_tract1.70706117
38MP0009697_abnormal_copulation1.70264580
39MP0006035_abnormal_mitochondrial_morpho1.68401302
40MP0002269_muscular_atrophy1.65502397
41MP0005551_abnormal_eye_electrophysiolog1.64623471
42MP0003111_abnormal_nucleus_morphology1.64362491
43MP0005330_cardiomyopathy1.62810125
44MP0005666_abnormal_adipose_tissue1.60791015
45MP0005636_abnormal_mineral_homeostasis1.59901817
46MP0002132_abnormal_respiratory_system1.54925426
47MP0000490_abnormal_crypts_of1.53989833
48MP0001764_abnormal_homeostasis1.53791469
49MP0005319_abnormal_enzyme/_coenzyme1.50022470
50MP0001666_abnormal_nutrient_absorption1.49363915
51MP0009840_abnormal_foam_cell1.48197063
52MP0000750_abnormal_muscle_regeneration1.47850658
53MP0008877_abnormal_DNA_methylation1.46673187
54MP0001529_abnormal_vocalization1.46670047
55MP0009046_muscle_twitch1.45345552
56MP0005332_abnormal_amino_acid1.44153318
57MP0003718_maternal_effect1.44079502
58MP0010329_abnormal_lipoprotein_level1.44038008
59MP0004085_abnormal_heartbeat1.43978255
60MP0005187_abnormal_penis_morphology1.43490836
61MP0010094_abnormal_chromosome_stability1.43199514
62MP0005397_hematopoietic_system_phenotyp1.41574217
63MP0001545_abnormal_hematopoietic_system1.41574217
64MP0003879_abnormal_hair_cell1.39933757
65MP0000013_abnormal_adipose_tissue1.39425203
66MP0004484_altered_response_of1.38778393
67MP0002102_abnormal_ear_morphology1.37776654
68MP0003077_abnormal_cell_cycle1.36865794
69MP0002733_abnormal_thermal_nociception1.34747608
70MP0008875_abnormal_xenobiotic_pharmacok1.33282904
71MP0000609_abnormal_liver_physiology1.33098567
72MP0004036_abnormal_muscle_relaxation1.32858646
73MP0008775_abnormal_heart_ventricle1.32198123
74MP0004185_abnormal_adipocyte_glucose1.30822943
75MP0005220_abnormal_exocrine_pancreas1.30745148
76MP0002106_abnormal_muscle_physiology1.28746573
77MP0004087_abnormal_muscle_fiber1.27820755
78MP0002638_abnormal_pupillary_reflex1.26531568
79MP0005375_adipose_tissue_phenotype1.25729120
80MP0009643_abnormal_urine_homeostasis1.25163338
81MP0005389_reproductive_system_phenotype1.24696066
82MP0002735_abnormal_chemical_nociception1.23331623
83MP0009745_abnormal_behavioral_response1.23181534
84MP0005410_abnormal_fertilization1.22823599
85MP0002272_abnormal_nervous_system1.21917982
86MP0004142_abnormal_muscle_tone1.21347752
87MP0000759_abnormal_skeletal_muscle1.20679026
88MP0005584_abnormal_enzyme/coenzyme_acti1.18614213
89MP0004084_abnormal_cardiac_muscle1.18601541
90MP0003638_abnormal_response/metabolism_1.18280425
91MP0005266_abnormal_metabolism1.17613333
92MP0002396_abnormal_hematopoietic_system1.17502325
93MP0001970_abnormal_pain_threshold1.16665641
94MP0002234_abnormal_pharynx_morphology1.16589565
95MP0003195_calcinosis1.15423981
96MP0000003_abnormal_adipose_tissue1.14428182
97MP0002078_abnormal_glucose_homeostasis1.11816084
98MP0000631_abnormal_neuroendocrine_gland1.11560461
99MP0002971_abnormal_brown_adipose1.10959220
100MP0001485_abnormal_pinna_reflex1.10934119
101MP0003567_abnormal_fetal_cardiomyocyte1.09849976
102MP0003221_abnormal_cardiomyocyte_apopto1.08460913
103MP0003283_abnormal_digestive_organ1.08049665
104MP0005535_abnormal_body_temperature1.06752825
105MP0003123_paternal_imprinting1.02573731
106MP0002909_abnormal_adrenal_gland1.02274046
107MP0008995_early_reproductive_senescence1.02192472
108MP0004134_abnormal_chest_morphology1.01975279
109MP0005645_abnormal_hypothalamus_physiol1.01637012
110MP0000358_abnormal_cell_content/1.01069683
111MP0001944_abnormal_pancreas_morphology1.00726308
112MP0002118_abnormal_lipid_homeostasis1.00516038
113MP0002693_abnormal_pancreas_physiology0.97011098
114MP0005334_abnormal_fat_pad0.95763419
115MP0003137_abnormal_impulse_conducting0.94534730
116MP0004924_abnormal_behavior0.94447502
117MP0005386_behavior/neurological_phenoty0.94447502
118MP0000598_abnormal_liver_morphology0.94170157
119MP0001664_abnormal_digestion0.94128021
120MP0005448_abnormal_energy_balance0.93887822
121MP0009379_abnormal_foot_pigmentation0.93768613
122MP0003880_abnormal_central_pattern0.91460868
123MP0005620_abnormal_muscle_contractility0.90954890
124MP0000383_abnormal_hair_follicle0.90602496
125MP0006138_congestive_heart_failure0.89790714
126MP0003953_abnormal_hormone_level0.89633714
127MP0010352_gastrointestinal_tract_polyps0.89094790
128MP0003787_abnormal_imprinting0.88147017
129MP0003868_abnormal_feces_composition0.88066727
130MP0005369_muscle_phenotype0.87803933
131MP0002970_abnormal_white_adipose0.87553352
132MP0005253_abnormal_eye_physiology0.86868921
133MP0001765_abnormal_ion_homeostasis0.85994467
134MP0003705_abnormal_hypodermis_morpholog0.84964196
135MP0003959_abnormal_lean_body0.83778529
136MP0002067_abnormal_sensory_capabilities0.82837149
137MP0002734_abnormal_mechanical_nocicepti0.82743438
138MP0002557_abnormal_social/conspecific_i0.82002738
139MP0005084_abnormal_gallbladder_morpholo0.81480382
140MP0002019_abnormal_tumor_incidence0.78094714
141MP0001730_embryonic_growth_arrest0.77177748
142MP0003136_yellow_coat_color0.76213941
143MP0001544_abnormal_cardiovascular_syste0.76183212
144MP0005385_cardiovascular_system_phenoty0.76183212
145MP0001919_abnormal_reproductive_system0.75965890
146MP0003698_abnormal_male_reproductive0.75392575
147MP0003763_abnormal_thymus_physiology0.75271070
148MP0008058_abnormal_DNA_repair0.75258795
149MP0004885_abnormal_endolymph0.73920840
150MP0009333_abnormal_splenocyte_physiolog0.73192677
151MP0005376_homeostasis/metabolism_phenot0.73068118
152MP0000313_abnormal_cell_death0.72929090
153MP0003191_abnormal_cellular_cholesterol0.72750983
154MP0010630_abnormal_cardiac_muscle0.72574767
155MP0002064_seizures0.72469605
156MP0002138_abnormal_hepatobiliary_system0.71967826
157MP0000427_abnormal_hair_cycle0.71835929
158MP0001756_abnormal_urination0.71504924
159MP0003635_abnormal_synaptic_transmissio0.71448849
160MP0001501_abnormal_sleep_pattern0.71133536
161MP0004233_abnormal_muscle_weight0.70652124
162MP0001853_heart_inflammation0.69679044
163MP0002080_prenatal_lethality0.68336375
164MP0003252_abnormal_bile_duct0.65270691
165MP0008469_abnormal_protein_level0.64759652
166MP0002972_abnormal_cardiac_muscle0.64309105
167MP0000350_abnormal_cell_proliferation0.62916575
168MP0005452_abnormal_adipose_tissue0.62177576

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)5.65377443
2Prolonged bleeding time (HP:0003010)5.62242234
3Menorrhagia (HP:0000132)5.48310976
4Abnormality of the heme biosynthetic pathway (HP:0010472)5.41584033
5Abnormality of cells of the erythroid lineage (HP:0012130)5.15790065
6Abnormal number of erythroid precursors (HP:0012131)5.10310292
7Abnormal platelet volume (HP:0011876)4.84582413
8Muscle fiber inclusion bodies (HP:0100299)4.67726373
9Petechiae (HP:0000967)4.36837369
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.30838334
11Nemaline bodies (HP:0003798)4.17352480
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.03883331
13Decreased activity of mitochondrial respiratory chain (HP:0008972)4.03883331
14Progressive muscle weakness (HP:0003323)3.84667051
15Myoglobinuria (HP:0002913)3.82625539
16Hyperlipoproteinemia (HP:0010980)3.78817033
17Purpura (HP:0000979)3.71386959
18Rhabdomyolysis (HP:0003201)3.66582189
19Hepatic necrosis (HP:0002605)3.65614769
20Exercise-induced muscle cramps (HP:0003710)3.58307833
21Hypoglycemic coma (HP:0001325)3.44425179
22Increased muscle lipid content (HP:0009058)3.41367481
23Hepatocellular necrosis (HP:0001404)3.38108302
24Abnormal mitochondria in muscle tissue (HP:0008316)3.31005826
25Type 1 muscle fiber predominance (HP:0003803)3.25921197
26Exercise-induced myalgia (HP:0003738)3.21716057
27Myopathic facies (HP:0002058)3.20499468
28Reticulocytopenia (HP:0001896)3.17701027
29Acute encephalopathy (HP:0006846)3.12840930
30Acute necrotizing encephalopathy (HP:0006965)3.12561521
31Increased intramyocellular lipid droplets (HP:0012240)3.11680574
32Ulnar deviation of the wrist (HP:0003049)2.99544236
33Mitochondrial inheritance (HP:0001427)2.97393997
34Dicarboxylic aciduria (HP:0003215)2.92974682
35Abnormality of dicarboxylic acid metabolism (HP:0010995)2.92974682
36Renal cortical cysts (HP:0000803)2.92700765
37Ketoacidosis (HP:0001993)2.92594586
38Increased CSF lactate (HP:0002490)2.91767695
39Ketosis (HP:0001946)2.84684110
40Lactic acidosis (HP:0003128)2.84019015
41Macrocytic anemia (HP:0001972)2.83575619
42Abnormality of alanine metabolism (HP:0010916)2.82574313
43Hyperalaninemia (HP:0003348)2.82574313
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.82574313
45Abnormality of reticulocytes (HP:0004312)2.81463093
46Epistaxis (HP:0000421)2.77175773
47Cerebral edema (HP:0002181)2.76656216
48Pallor (HP:0000980)2.76491971
49Hyperthyroidism (HP:0000836)2.73431341
50Hyperammonemia (HP:0001987)2.73246039
51Increased serum lactate (HP:0002151)2.70408784
52Abnormality of the renal cortex (HP:0011035)2.69414164
53Poikilocytosis (HP:0004447)2.68371133
54Hyperventilation (HP:0002883)2.65813942
55Exercise intolerance (HP:0003546)2.64105652
56Reticulocytosis (HP:0001923)2.61079255
57Hyperbilirubinemia (HP:0002904)2.58469219
583-Methylglutaconic aciduria (HP:0003535)2.57647096
59Nausea (HP:0002018)2.56523784
60Birth length less than 3rd percentile (HP:0003561)2.54880696
61Decreased central vision (HP:0007663)2.54674857
62Distal arthrogryposis (HP:0005684)2.52965289
63Progressive macrocephaly (HP:0004481)2.49861789
64Multiple enchondromatosis (HP:0005701)2.49497979
65Bundle branch block (HP:0011710)2.49443423
66Lipid accumulation in hepatocytes (HP:0006561)2.48381862
67Increased serum ferritin (HP:0003281)2.48066350
68Muscle hypertrophy of the lower extremities (HP:0008968)2.46531479
69Pancreatic cysts (HP:0001737)2.45750771
70Calf muscle hypertrophy (HP:0008981)2.44374467
71Hyperglycinemia (HP:0002154)2.42781690
72Abnormality of fatty-acid metabolism (HP:0004359)2.42654208
73Impaired platelet aggregation (HP:0003540)2.42376594
74Abnormal platelet function (HP:0011869)2.42376594
75Muscle stiffness (HP:0003552)2.41804437
76Pancreatic fibrosis (HP:0100732)2.40023082
77Acanthocytosis (HP:0001927)2.39785319
78Generalized aminoaciduria (HP:0002909)2.39499505
79Gingival bleeding (HP:0000225)2.37376798
80Ragged-red muscle fibers (HP:0003200)2.36790776
81Ventricular fibrillation (HP:0001663)2.36573793
82Tinnitus (HP:0000360)2.35816548
83Lethargy (HP:0001254)2.35784053
84Global brain atrophy (HP:0002283)2.34731226
85Hyperglycinuria (HP:0003108)2.32939628
86Testicular atrophy (HP:0000029)2.32578298
87Abnormality of aromatic amino acid family metabolism (HP:0004338)2.30721198
88Congenital stationary night blindness (HP:0007642)2.29866574
89Respiratory failure (HP:0002878)2.28511505
90Dyschromatopsia (HP:0007641)2.23341468
91Abnormality of glycine metabolism (HP:0010895)2.21404667
92Abnormality of serine family amino acid metabolism (HP:0010894)2.21404667
93Brushfield spots (HP:0001088)2.18130197
94CNS demyelination (HP:0007305)2.17988897
95Abnormality of transition element cation homeostasis (HP:0011030)2.17403126
96Muscle fiber splitting (HP:0003555)2.16910870
97Diaphragmatic weakness (HP:0009113)2.16752664
98Microretrognathia (HP:0000308)2.16500456
99Paralysis (HP:0003470)2.16269073
100Late onset (HP:0003584)2.15958832
101Increased hepatocellular lipid droplets (HP:0006565)2.15802123
102Thyroid-stimulating hormone excess (HP:0002925)2.14440936
103Hypothermia (HP:0002045)2.12966300
104Areflexia of lower limbs (HP:0002522)2.09439508
105Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.08705571
106Abnormality of serum amino acid levels (HP:0003112)2.08515416
107Cholelithiasis (HP:0001081)2.06925335
108Abnormality of iron homeostasis (HP:0011031)2.06756385
109Hypoglycemic seizures (HP:0002173)2.06230110
110Degeneration of the lateral corticospinal tracts (HP:0002314)2.05442041
111Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.05442041
112True hermaphroditism (HP:0010459)2.02081398
113Abolished electroretinogram (ERG) (HP:0000550)2.00520105
114Aplastic anemia (HP:0001915)2.00126252
115Central scotoma (HP:0000603)1.99252201
116Calcaneovalgus deformity (HP:0001848)1.98320318
117Round ear (HP:0100830)1.97924949
118Renal Fanconi syndrome (HP:0001994)1.96710862
119Subaortic stenosis (HP:0001682)1.95160816
120Abnormality of the left ventricular outflow tract (HP:0011103)1.95160816
121Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94057924
122Conjunctival hamartoma (HP:0100780)1.93705228
123Male pseudohermaphroditism (HP:0000037)1.93046659
124Hyperinsulinemic hypoglycemia (HP:0000825)1.91920862
125Glycosuria (HP:0003076)1.91784431
126Abnormality of urine glucose concentration (HP:0011016)1.91784431
127Abnormal gallbladder morphology (HP:0012437)1.91327047
128Metabolic acidosis (HP:0001942)1.91198471
129Gaze-evoked nystagmus (HP:0000640)1.90580318
130Congenital sensorineural hearing impairment (HP:0008527)1.89861819
131Methylmalonic aciduria (HP:0012120)1.88444315
132Rimmed vacuoles (HP:0003805)1.87609706
133Polycythemia (HP:0001901)1.87214906
134Vomiting (HP:0002013)1.86096580
135Type II lissencephaly (HP:0007260)1.84789862
136Aplasia/Hypoplasia of the tibia (HP:0005772)1.83565212
137Abnormality of lateral ventricle (HP:0030047)1.83411281
138Medial flaring of the eyebrow (HP:0010747)1.82988127
139Deformed tarsal bones (HP:0008119)1.82234021
140Dilated cardiomyopathy (HP:0001644)1.81888374
141Febrile seizures (HP:0002373)1.81269839
142Palpitations (HP:0001962)1.80902792
143Metaphyseal dysplasia (HP:0100255)1.80168751
144Neuroendocrine neoplasm (HP:0100634)1.78307533
145Abnormal pupillary function (HP:0007686)1.76416213
146Truncus arteriosus (HP:0001660)1.70250796
147Congenital, generalized hypertrichosis (HP:0004540)1.65147879
148Papillary thyroid carcinoma (HP:0002895)1.63827795
149Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.61642208
150Pachygyria (HP:0001302)1.61402535
151Hypophosphatemic rickets (HP:0004912)1.60752176
152Syncope (HP:0001279)1.59455120
153Abnormality of midbrain morphology (HP:0002418)1.58466223
154Molar tooth sign on MRI (HP:0002419)1.58466223
155Broad-based gait (HP:0002136)1.57935845
156Heart block (HP:0012722)1.57711301
157Proximal tubulopathy (HP:0000114)1.56011532
158Clumsiness (HP:0002312)1.55982805
159Gait imbalance (HP:0002141)1.55678401
160Hypomagnesemia (HP:0002917)1.54089039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.57922737
2BCKDK4.05382495
3OBSCN3.93998280
4TRIB33.56424431
5EIF2AK13.29423390
6NME13.22044751
7MST43.06331349
8PKN22.99503996
9MYLK2.86210865
10SCYL22.43109732
11BMPR1B2.38618441
12ADRBK22.25345934
13FLT32.12744121
14NEK12.07445079
15GRK12.06639907
16PIK3CG2.06584782
17STK162.05157561
18EEF2K2.03653615
19TTN1.97011530
20WEE11.93776603
21TNIK1.93523749
22NUAK11.89973534
23MAP3K111.84740057
24ERN11.80690455
25STK391.70175302
26CDC71.62754395
27BMX1.62402776
28MAP4K21.62364361
29PDK31.62350956
30PDK41.62350956
31CASK1.56050271
32DAPK21.52269260
33MAP3K101.52130036
34TLK11.50143541
35VRK11.49391345
36MAP3K41.49232194
37MAP2K31.45752136
38PLK21.45667187
39BMPR21.45367840
40MAPK131.45107525
41BRSK21.42945555
42TEC1.42238298
43DYRK31.40293886
44PIM21.39785837
45PNCK1.36613353
46TRIM281.34929545
47PINK11.33554871
48WNK31.30469713
49NEK21.26378944
50PAK31.26205345
51RPS6KA41.25814993
52STK31.25690679
53ILK1.25149117
54LRRK21.23884671
55TAOK31.22808293
56SIK11.19057740
57OXSR11.18051023
58EIF2AK31.17783517
59RPS6KB21.17557093
60NTRK31.16724306
61KDR1.15148169
62GRK51.14575395
63BUB11.08333706
64AKT31.07729639
65MAPKAPK31.05817934
66INSRR1.04002261
67MAPK111.01556361
68PTK2B0.97908338
69RIPK40.96266743
70CDK40.94604281
71MAP3K120.91612817
72ADRBK10.90044872
73MAP2K10.89738425
74PHKG20.88327983
75PHKG10.88327983
76FER0.87045118
77MAP2K60.87030341
78MAP3K80.85785248
79PRKCE0.84539868
80MAP2K70.84506013
81MUSK0.83819511
82MAP4K10.83038168
83AURKB0.82933379
84ACVR1B0.76607416
85DYRK20.75972746
86AKT20.74479107
87DAPK30.72979141
88PAK40.72308386
89RAF10.71573275
90CAMKK20.71526468
91STK38L0.71242243
92PASK0.71017283
93TTK0.70899669
94MAPK120.70305500
95NEK90.69882304
96TSSK60.69747357
97ZAP700.68551820
98MARK10.68352741
99CAMK2A0.68293285
100MAP3K70.67535927
101ABL20.66135262
102MINK10.66084057
103MAP3K30.64531509
104PRKCG0.64433598
105PIK3CA0.64149616
106CSNK1G20.61774156
107PTK60.61443009
108JAK20.60912508
109SRPK10.59762367
110MAP3K50.59604595
111CDK80.59066138
112EPHA30.58703323
113PDK20.58360522
114BRAF0.56382468
115PRKACA0.56197821
116BTK0.56136479
117TIE10.55557565
118SGK20.55406837
119PRKACG0.55323966
120PRKAA20.55284377
121CSNK2A20.54909518
122CSNK1G30.54707159
123TNK20.53926535
124JAK30.53755495
125CDK60.53214644
126AURKA0.52405123
127HIPK20.51945871
128ZAK0.51153674
129CSNK1G10.50906191
130TGFBR10.50031178
131DAPK10.49950870
132BRSK10.49689154
133PLK10.49324236
134DMPK0.49198377
135BCR0.48787007
136CAMK2D0.47900261
137CAMK10.47775199
138PRKG10.46848887
139PAK10.46112224
140LMTK20.45534773
141NLK0.45203079
142MAP2K40.45149316
143ERBB30.44545855
144CSNK2A10.44399608
145PKN10.43680609
146MAPKAPK50.43679047
147CAMK2G0.43340098
148FRK0.42864445
149ERBB20.42690378
150CAMK1G0.42572047
151PLK30.41278938
152CCNB10.41003775
153ATR0.40285765
154CDK70.39585209
155PRKCA0.39445583
156IRAK30.39368702
157MAP2K20.39105949
158TESK20.38253934
159STK100.37914259
160ARAF0.37736597
161TAOK10.37114354
162WNK40.37020781
163TRPM70.36020398
164PIM10.33816911
165CSNK1A1L0.33293007
166PLK40.32502922
167RPS6KA50.31149567
168MAP3K10.30275977
169RPS6KA10.29351689
170EPHA20.26872365
171TYK20.26631974

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.17551631
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.06137615
3DNA replication_Homo sapiens_hsa030302.93826596
4Protein export_Homo sapiens_hsa030602.64963335
5Fatty acid elongation_Homo sapiens_hsa000622.43826707
6Parkinsons disease_Homo sapiens_hsa050122.42106601
7Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.33911401
8Propanoate metabolism_Homo sapiens_hsa006402.30768199
9Proteasome_Homo sapiens_hsa030502.24638732
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23285889
11Oxidative phosphorylation_Homo sapiens_hsa001902.22281607
12Sulfur relay system_Homo sapiens_hsa041222.11753906
13Pyrimidine metabolism_Homo sapiens_hsa002402.05921742
14RNA polymerase_Homo sapiens_hsa030201.99441766
15Fatty acid degradation_Homo sapiens_hsa000711.99155314
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96042899
17Folate biosynthesis_Homo sapiens_hsa007901.92067176
18Carbon metabolism_Homo sapiens_hsa012001.91173625
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.88474425
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87713320
21Mismatch repair_Homo sapiens_hsa034301.87179862
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85034971
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84624857
24One carbon pool by folate_Homo sapiens_hsa006701.82234535
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72659641
26Pyruvate metabolism_Homo sapiens_hsa006201.66228229
27Huntingtons disease_Homo sapiens_hsa050161.65871317
28Platelet activation_Homo sapiens_hsa046111.62724961
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.62428101
30Biosynthesis of amino acids_Homo sapiens_hsa012301.62332617
31Pentose phosphate pathway_Homo sapiens_hsa000301.59733201
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.56804590
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.54963236
34Phototransduction_Homo sapiens_hsa047441.53346126
35Caffeine metabolism_Homo sapiens_hsa002321.48265631
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47830847
37Selenocompound metabolism_Homo sapiens_hsa004501.46180435
38Sulfur metabolism_Homo sapiens_hsa009201.44974507
39Alzheimers disease_Homo sapiens_hsa050101.43928264
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.37800414
41RNA transport_Homo sapiens_hsa030131.34958196
42Spliceosome_Homo sapiens_hsa030401.34760332
43Nucleotide excision repair_Homo sapiens_hsa034201.33179157
44Serotonergic synapse_Homo sapiens_hsa047261.32294374
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31994404
46Retinol metabolism_Homo sapiens_hsa008301.29592491
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28359331
48* Linoleic acid metabolism_Homo sapiens_hsa005911.28168150
49Base excision repair_Homo sapiens_hsa034101.25783771
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24606614
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23380845
52Cardiac muscle contraction_Homo sapiens_hsa042601.16933350
53* Arachidonic acid metabolism_Homo sapiens_hsa005901.13068402
54Fatty acid metabolism_Homo sapiens_hsa012121.12283594
55beta-Alanine metabolism_Homo sapiens_hsa004101.10393119
56Peroxisome_Homo sapiens_hsa041461.09846268
57Nicotine addiction_Homo sapiens_hsa050331.08215686
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07960897
59Circadian entrainment_Homo sapiens_hsa047131.07709064
60Homologous recombination_Homo sapiens_hsa034401.04614811
61Purine metabolism_Homo sapiens_hsa002301.02484458
62Morphine addiction_Homo sapiens_hsa050321.00864047
63* alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99901697
64Olfactory transduction_Homo sapiens_hsa047400.99410025
65GABAergic synapse_Homo sapiens_hsa047270.97279003
66PPAR signaling pathway_Homo sapiens_hsa033200.95930490
67Arginine biosynthesis_Homo sapiens_hsa002200.95053449
68Arginine and proline metabolism_Homo sapiens_hsa003300.92352190
69* Vascular smooth muscle contraction_Homo sapiens_hsa042700.92304249
70Starch and sucrose metabolism_Homo sapiens_hsa005000.91721262
71Steroid biosynthesis_Homo sapiens_hsa001000.91670089
72N-Glycan biosynthesis_Homo sapiens_hsa005100.91441737
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90827711
74RNA degradation_Homo sapiens_hsa030180.90269202
75* Pancreatic secretion_Homo sapiens_hsa049720.88850547
76Galactose metabolism_Homo sapiens_hsa000520.86597330
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85726410
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84930671
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83896693
80Insulin secretion_Homo sapiens_hsa049110.83371726
81Glutathione metabolism_Homo sapiens_hsa004800.82393629
82* Metabolic pathways_Homo sapiens_hsa011000.81252282
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78612616
84Long-term depression_Homo sapiens_hsa047300.78078175
85Cell cycle_Homo sapiens_hsa041100.77613798
86Renin-angiotensin system_Homo sapiens_hsa046140.77377179
87Tryptophan metabolism_Homo sapiens_hsa003800.77072456
88Glutamatergic synapse_Homo sapiens_hsa047240.76577358
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76483206
90Collecting duct acid secretion_Homo sapiens_hsa049660.76180532
91Calcium signaling pathway_Homo sapiens_hsa040200.75611179
92ECM-receptor interaction_Homo sapiens_hsa045120.75387485
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74759825
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.73953773
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73915036
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73645080
97Fructose and mannose metabolism_Homo sapiens_hsa000510.70865280
98Histidine metabolism_Homo sapiens_hsa003400.70227892
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69226450
100Circadian rhythm_Homo sapiens_hsa047100.69135178
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67402320
102Dilated cardiomyopathy_Homo sapiens_hsa054140.66612230
103Ovarian steroidogenesis_Homo sapiens_hsa049130.66559536
104* Fat digestion and absorption_Homo sapiens_hsa049750.65330586
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62359245
106Alcoholism_Homo sapiens_hsa050340.61855362
107Non-homologous end-joining_Homo sapiens_hsa034500.61099437
108Taste transduction_Homo sapiens_hsa047420.60669122
109Gap junction_Homo sapiens_hsa045400.59799291
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59352485
111Vitamin B6 metabolism_Homo sapiens_hsa007500.58884197
112Bile secretion_Homo sapiens_hsa049760.57400891
113Nitrogen metabolism_Homo sapiens_hsa009100.56079280
114Systemic lupus erythematosus_Homo sapiens_hsa053220.55196358
115p53 signaling pathway_Homo sapiens_hsa041150.55104626
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54710837
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54186582
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.52724616
119Butanoate metabolism_Homo sapiens_hsa006500.51050104
120Fatty acid biosynthesis_Homo sapiens_hsa000610.49722742
121Fanconi anemia pathway_Homo sapiens_hsa034600.45123723
122AMPK signaling pathway_Homo sapiens_hsa041520.43128599
123ABC transporters_Homo sapiens_hsa020100.42663308
124Basal transcription factors_Homo sapiens_hsa030220.39451753
125Glycerolipid metabolism_Homo sapiens_hsa005610.39395267
126Insulin resistance_Homo sapiens_hsa049310.39164099
127Glucagon signaling pathway_Homo sapiens_hsa049220.37855654
128Phenylalanine metabolism_Homo sapiens_hsa003600.35004623
129Insulin signaling pathway_Homo sapiens_hsa049100.34069360
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30814942
131Tyrosine metabolism_Homo sapiens_hsa003500.29899946
132Thyroid cancer_Homo sapiens_hsa052160.29142350
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27977028
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.25674935
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.24829689
136Chemical carcinogenesis_Homo sapiens_hsa052040.21710442
137Bladder cancer_Homo sapiens_hsa052190.18680215
138Antigen processing and presentation_Homo sapiens_hsa046120.17976781
139Legionellosis_Homo sapiens_hsa051340.17662195
140Acute myeloid leukemia_Homo sapiens_hsa052210.17263449
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17205706
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17126198
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15667480

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