PLA2G10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA catabolic process (GO:0016075)5.68547951
2behavioral response to nicotine (GO:0035095)5.47442725
3cilium or flagellum-dependent cell motility (GO:0001539)5.08169404
4histone-serine phosphorylation (GO:0035404)4.86704592
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.84568282
6ribosome assembly (GO:0042255)4.76771940
7chaperone-mediated protein complex assembly (GO:0051131)4.65748306
8detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.63317469
9axonemal dynein complex assembly (GO:0070286)4.61754065
10epithelial cilium movement (GO:0003351)4.51159502
11purine nucleobase biosynthetic process (GO:0009113)4.35888664
12cilium movement (GO:0003341)4.20352943
13fucose catabolic process (GO:0019317)4.19277092
14L-fucose metabolic process (GO:0042354)4.19277092
15L-fucose catabolic process (GO:0042355)4.19277092
16nucleobase biosynthetic process (GO:0046112)4.18632772
17protein localization to cilium (GO:0061512)4.16811367
18DNA methylation involved in gamete generation (GO:0043046)4.14795628
19interferon-gamma secretion (GO:0072643)4.08382667
20formation of translation preinitiation complex (GO:0001731)4.04573312
21axoneme assembly (GO:0035082)3.93003998
22intestinal epithelial cell development (GO:0060576)3.85362227
23DNA replication initiation (GO:0006270)3.79889516
24male meiosis I (GO:0007141)3.78626051
25ribosome biogenesis (GO:0042254)3.78585611
26male meiosis (GO:0007140)3.77831342
27ncRNA catabolic process (GO:0034661)3.77430088
28folic acid metabolic process (GO:0046655)3.76890406
29ribosomal large subunit biogenesis (GO:0042273)3.73142873
30maturation of SSU-rRNA (GO:0030490)3.71952043
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.69117828
32blastocyst development (GO:0001824)3.64334970
33synaptonemal complex assembly (GO:0007130)3.62479052
34ribonucleoprotein complex biogenesis (GO:0022613)3.61460627
35rRNA modification (GO:0000154)3.57717659
36negative regulation of T cell differentiation in thymus (GO:0033085)3.56458438
37mitotic metaphase plate congression (GO:0007080)3.55468880
38chromosome condensation (GO:0030261)3.53111296
39DNA strand elongation involved in DNA replication (GO:0006271)3.46946451
40ribosomal small subunit biogenesis (GO:0042274)3.45565153
41detection of light stimulus involved in visual perception (GO:0050908)3.44566910
42detection of light stimulus involved in sensory perception (GO:0050962)3.44566910
43chromatin remodeling at centromere (GO:0031055)3.43049099
44regulation of cilium movement (GO:0003352)3.36155046
45regulation of glucocorticoid secretion (GO:2000849)3.35810780
46regulation of posttranscriptional gene silencing (GO:0060147)3.35453024
47regulation of gene silencing by miRNA (GO:0060964)3.35453024
48regulation of gene silencing by RNA (GO:0060966)3.35453024
49protein K11-linked deubiquitination (GO:0035871)3.35396189
50synaptonemal complex organization (GO:0070193)3.35342831
51DNA replication-dependent nucleosome assembly (GO:0006335)3.33074204
52DNA replication-dependent nucleosome organization (GO:0034723)3.33074204
53DNA packaging (GO:0006323)3.32658877
54motile cilium assembly (GO:0044458)3.32152461
55histone exchange (GO:0043486)3.32072847
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30408803
57CENP-A containing nucleosome assembly (GO:0034080)3.30274295
58DNA strand elongation (GO:0022616)3.25762611
59anterograde synaptic vesicle transport (GO:0048490)3.25056896
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.24229234
61GDP-mannose metabolic process (GO:0019673)3.23778185
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23759698
63fatty acid homeostasis (GO:0055089)3.22509468
64telomere maintenance via semi-conservative replication (GO:0032201)3.22213040
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.19640498
66cilium morphogenesis (GO:0060271)3.15622608
67rRNA metabolic process (GO:0016072)3.15178958
68response to pheromone (GO:0019236)3.15015692
69piRNA metabolic process (GO:0034587)3.14779539
70ribosomal small subunit assembly (GO:0000028)3.14736847
71kinetochore assembly (GO:0051382)3.14150056
72metallo-sulfur cluster assembly (GO:0031163)3.13962281
73iron-sulfur cluster assembly (GO:0016226)3.13962281
74nonmotile primary cilium assembly (GO:0035058)3.13414421
75exogenous drug catabolic process (GO:0042738)3.13215675
76DNA replication checkpoint (GO:0000076)3.12282480
77cellular response to glucose starvation (GO:0042149)3.11992148
78mitotic nuclear envelope disassembly (GO:0007077)3.11902720
79cellular ketone body metabolic process (GO:0046950)3.11734111
80proteasome assembly (GO:0043248)3.11189909
81photoreceptor cell maintenance (GO:0045494)3.06884452
82protein complex localization (GO:0031503)3.06175011
83cilium organization (GO:0044782)3.05676377
84binding of sperm to zona pellucida (GO:0007339)3.04089090
85oligosaccharide biosynthetic process (GO:0009312)3.02987978
86sperm-egg recognition (GO:0035036)3.01744489
87protein polyglutamylation (GO:0018095)3.01580286
88cilium assembly (GO:0042384)3.01475494
89somatic hypermutation of immunoglobulin genes (GO:0016446)3.01284109
90somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01284109
91folic acid transport (GO:0015884)3.01007788
92chromosome organization involved in meiosis (GO:0070192)3.00512026
93drug catabolic process (GO:0042737)3.00362679
947-methylguanosine mRNA capping (GO:0006370)2.99538796
95synapsis (GO:0007129)2.99276393
96UDP-N-acetylglucosamine metabolic process (GO:0006047)2.99144354
97inner cell mass cell proliferation (GO:0001833)2.98242189
98regulation of cellular amino acid metabolic process (GO:0006521)2.96451591
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.96278826
100translational initiation (GO:0006413)2.95883067
101rRNA processing (GO:0006364)2.95484585
102DNA replication-independent nucleosome organization (GO:0034724)2.95101937
103DNA replication-independent nucleosome assembly (GO:0006336)2.95101937
104base-excision repair, AP site formation (GO:0006285)2.94858585
105reflex (GO:0060004)2.94843232
106protein K6-linked ubiquitination (GO:0085020)2.94045946
107regulation of mitochondrial translation (GO:0070129)2.93689560
108intraciliary transport (GO:0042073)2.93318555
109negative regulation of ligase activity (GO:0051352)2.92808058
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92808058
111nuclear envelope disassembly (GO:0051081)2.92807564
112membrane disassembly (GO:0030397)2.92807564
113reciprocal DNA recombination (GO:0035825)2.92110826
114reciprocal meiotic recombination (GO:0007131)2.92110826
115protein localization to kinetochore (GO:0034501)2.91917903
116negative regulation of translational initiation (GO:0045947)2.90437727
117nuclear pore organization (GO:0006999)2.90350759
118kinetochore organization (GO:0051383)2.90273889
119metaphase plate congression (GO:0051310)2.89195858
120termination of RNA polymerase III transcription (GO:0006386)2.86388941
121transcription elongation from RNA polymerase III promoter (GO:0006385)2.86388941
122RNA capping (GO:0036260)2.85073290
1237-methylguanosine RNA capping (GO:0009452)2.85073290
124water-soluble vitamin biosynthetic process (GO:0042364)2.84688729
125cell-cell recognition (GO:0009988)2.84341481
126regulation of appetite (GO:0032098)2.84088862
127carnitine shuttle (GO:0006853)2.83169626
128telomere maintenance via recombination (GO:0000722)2.82566534
129auditory receptor cell stereocilium organization (GO:0060088)2.82505529
130regulation of centriole replication (GO:0046599)2.81434221
131ketone body metabolic process (GO:1902224)2.80183278
132regulation of centrosome cycle (GO:0046605)2.78186200
133cornea development in camera-type eye (GO:0061303)2.77926213
134arginine metabolic process (GO:0006525)2.77871844
135ubiquinone biosynthetic process (GO:0006744)2.77856157
136indolalkylamine metabolic process (GO:0006586)2.77532448
137regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.77431085
138preassembly of GPI anchor in ER membrane (GO:0016254)2.77302962
139viral transcription (GO:0019083)2.76799187
140telomere maintenance via telomere lengthening (GO:0010833)2.76541952
141protein localization to chromosome, centromeric region (GO:0071459)2.76243029
142synaptic transmission, cholinergic (GO:0007271)2.75813613
143galactose catabolic process (GO:0019388)2.75509999
144cell wall macromolecule catabolic process (GO:0016998)2.73902549
145cell wall macromolecule metabolic process (GO:0044036)2.73902549
146translational elongation (GO:0006414)2.73696843
147translational termination (GO:0006415)2.73624969
148positive regulation of ligase activity (GO:0051351)2.73317811
149regulation of translation in response to stress (GO:0043555)2.72578850
150DNA deamination (GO:0045006)2.72514898
151meiosis I (GO:0007127)2.72409054
152regulation of microtubule-based movement (GO:0060632)2.71868501
153DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.71754047
154keratinocyte development (GO:0003334)2.68688829
155regulation of hexokinase activity (GO:1903299)2.67615773
156regulation of glucokinase activity (GO:0033131)2.67615773
157positive regulation of defense response to virus by host (GO:0002230)2.65696824
158fucosylation (GO:0036065)2.65216972
159cysteine metabolic process (GO:0006534)2.64542220
160platelet dense granule organization (GO:0060155)2.64128080
161cAMP catabolic process (GO:0006198)2.63895079
162positive regulation of oligodendrocyte differentiation (GO:0048714)2.63417743
163sulfation (GO:0051923)2.62127500
164neuronal action potential (GO:0019228)2.61442669
165detection of mechanical stimulus involved in sensory perception (GO:0050974)2.61269566
166indole-containing compound catabolic process (GO:0042436)2.60561937
167indolalkylamine catabolic process (GO:0046218)2.60561937
168tryptophan catabolic process (GO:0006569)2.60561937
169adaptation of signaling pathway (GO:0023058)2.58585734
170arginine catabolic process (GO:0006527)2.57873456
171inner ear receptor cell development (GO:0060119)2.56614178
172seminiferous tubule development (GO:0072520)2.55249939
173regulation of corticosteroid hormone secretion (GO:2000846)2.53703529
174respiratory chain complex IV assembly (GO:0008535)2.49978544
175tryptophan metabolic process (GO:0006568)2.48836754
176multicellular organism reproduction (GO:0032504)2.48644682
177inner ear receptor stereocilium organization (GO:0060122)2.48471091
178meiotic chromosome segregation (GO:0045132)2.47818277
179quinone biosynthetic process (GO:1901663)2.47632394
180protein complex biogenesis (GO:0070271)2.45956544
181* phosphatidylinositol acyl-chain remodeling (GO:0036149)2.45877198
182ubiquinone metabolic process (GO:0006743)2.44841691
183centriole replication (GO:0007099)2.44400342
184regulation of guanylate cyclase activity (GO:0031282)2.43719044
185regulation of meiosis I (GO:0060631)2.43699404
186primary amino compound metabolic process (GO:1901160)2.42408970
187* phosphatidylserine acyl-chain remodeling (GO:0036150)2.41400582
188positive regulation of guanylate cyclase activity (GO:0031284)2.40561945
189protein neddylation (GO:0045116)2.40452575
190cyclic nucleotide catabolic process (GO:0009214)2.40166705
191negative regulation of transcription regulatory region DNA binding (GO:2000678)2.40145041
192GPI anchor metabolic process (GO:0006505)2.38855965
193regulation of nuclear cell cycle DNA replication (GO:0033262)2.37802660
194negative regulation of mast cell activation (GO:0033004)2.37539109
195negative regulation of telomere maintenance (GO:0032205)2.36570218
196kynurenine metabolic process (GO:0070189)2.36258101

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.19688684
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.04954880
3ZNF274_21170338_ChIP-Seq_K562_Hela3.48875743
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.41699357
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.39918171
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.32328752
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05525642
8VDR_22108803_ChIP-Seq_LS180_Human2.84653369
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80254537
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76588647
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.72054627
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69523402
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.67681547
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.64649351
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63480411
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60515754
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.57175997
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.56906697
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.56883445
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56829250
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56195259
22NANOG_18555785_ChIP-Seq_MESCs_Mouse2.52493641
23IGF1R_20145208_ChIP-Seq_DFB_Human2.48704954
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37177281
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.34284014
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27460848
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24884417
28GBX2_23144817_ChIP-Seq_PC3_Human2.21869544
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.20303834
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.20006497
31GABP_17652178_ChIP-ChIP_JURKAT_Human2.18003053
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17574701
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.16764136
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.16764136
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.16764136
36STAT3_1855785_ChIP-Seq_MESCs_Mouse2.12960413
37AR_21909140_ChIP-Seq_LNCAP_Human2.11585957
38XRN2_22483619_ChIP-Seq_HELA_Human2.07435025
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.05789373
40ER_23166858_ChIP-Seq_MCF-7_Human2.04792868
41NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04763440
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.03265184
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97387499
44EZH2_22144423_ChIP-Seq_EOC_Human1.97309772
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95891743
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95454018
47* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.93967307
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93158837
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92956329
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90723487
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.90419845
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.89914349
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87157515
54VDR_23849224_ChIP-Seq_CD4+_Human1.84259544
55FUS_26573619_Chip-Seq_HEK293_Human1.83720649
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82534214
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.80592830
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.79881522
59BCAT_22108803_ChIP-Seq_LS180_Human1.76726252
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73804831
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73517257
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70655456
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67375789
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66350950
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65754785
66TP53_22573176_ChIP-Seq_HFKS_Human1.65199485
67P300_19829295_ChIP-Seq_ESCs_Human1.59844262
68TAF15_26573619_Chip-Seq_HEK293_Human1.58462457
69* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55583986
70* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.54554807
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.52901716
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48691870
73NCOR_22424771_ChIP-Seq_293T_Human1.48170706
74SMAD4_21799915_ChIP-Seq_A2780_Human1.47458642
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46854060
76* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.45633442
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45397705
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45247976
79IRF1_19129219_ChIP-ChIP_H3396_Human1.44900316
80CBP_20019798_ChIP-Seq_JUKART_Human1.42708619
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42708619
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.42253130
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42253130
84TTF2_22483619_ChIP-Seq_HELA_Human1.41318990
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41305419
86AR_20517297_ChIP-Seq_VCAP_Human1.40357220
87GABP_19822575_ChIP-Seq_HepG2_Human1.40247249
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39756057
89HOXB7_26014856_ChIP-Seq_BT474_Human1.38135249
90EWS_26573619_Chip-Seq_HEK293_Human1.37359153
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.37310877
92ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36173395
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35935617
94* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.35685755
95FOXP3_21729870_ChIP-Seq_TREG_Human1.35586174
96SOX2_19829295_ChIP-Seq_ESCs_Human1.35547758
97NANOG_19829295_ChIP-Seq_ESCs_Human1.35547758
98AR_25329375_ChIP-Seq_VCAP_Human1.35486208
99MYC_18940864_ChIP-ChIP_HL60_Human1.35192958
100* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.33914324
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.33062845
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32973663
103IRF8_22096565_ChIP-ChIP_GC-B_Human1.31790904
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31183090
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30916553
106STAT3_23295773_ChIP-Seq_U87_Human1.29220054
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29133853
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28542129
109SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.28350233
110ZNF263_19887448_ChIP-Seq_K562_Human1.27895956
111CDX2_22108803_ChIP-Seq_LS180_Human1.27200054
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26863912
113KDM5A_27292631_Chip-Seq_BREAST_Human1.26437364
114TCF4_22108803_ChIP-Seq_LS180_Human1.25944644
115SALL1_21062744_ChIP-ChIP_HESCs_Human1.25445777
116KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24942383
117BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24346055
118AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24005191
119* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.23263863
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23220755
121* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22745216
122SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22165697
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21444659
124DCP1A_22483619_ChIP-Seq_HELA_Human1.20388689
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.20341344
126SMAD4_21741376_ChIP-Seq_EPCs_Human1.19597057
127* TCF4_23295773_ChIP-Seq_U87_Human1.18652907
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18392774
129EZH2_27294783_Chip-Seq_NPCs_Mouse1.18388208
130RUNX2_22187159_ChIP-Seq_PCA_Human1.17850572
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17302501
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16119979
133NANOG_20526341_ChIP-Seq_ESCs_Human1.15975794
134NFE2_27457419_Chip-Seq_LIVER_Mouse1.15106181
135MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14591107
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14354944
137PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14137415
138THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14093061
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13797324
140* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13256572
141KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13232842
142* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.12791947
143CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12782322
144KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12738714
145* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12624858
146ETV1_20927104_ChIP-Seq_GIST48_Human1.11310255
147FOXH1_21741376_ChIP-Seq_EPCs_Human1.10515264
148SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10453377
149STAT3_18555785_Chip-Seq_ESCs_Mouse1.10103646
150E2F1_21310950_ChIP-Seq_MCF-7_Human1.08286058
151ERA_21632823_ChIP-Seq_H3396_Human1.08137847
152FLI1_21867929_ChIP-Seq_TH2_Mouse1.07709768
153* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07507676
154PRDM14_20953172_ChIP-Seq_ESCs_Human1.07391729
155ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07213171
156KAP1_27257070_Chip-Seq_ESCs_Mouse1.06333652
157REST_21632747_ChIP-Seq_MESCs_Mouse1.05217599
158ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05057249
159MYC_19829295_ChIP-Seq_ESCs_Human1.04986172
160ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04850298
161SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04007950
162HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03842933
163ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03586051
164* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.03085700
165SMAD3_21741376_ChIP-Seq_EPCs_Human1.02876789
166TAF2_19829295_ChIP-Seq_ESCs_Human1.02569212
167CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02520332
168SRF_21415370_ChIP-Seq_HL-1_Mouse1.02329532
169CRX_20693478_ChIP-Seq_RETINA_Mouse1.02305223
170PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01436467
171YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99379354
172EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99291784
173P53_22387025_ChIP-Seq_ESCs_Mouse0.98848910
174TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98792613
175CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98522394
176ELK1_19687146_ChIP-ChIP_HELA_Human0.98348646
177RBPJ_21746931_ChIP-Seq_IB4_Human0.98237552
178NANOG_21062744_ChIP-ChIP_HESCs_Human0.97843400
179RNF2_27304074_Chip-Seq_NSC_Mouse0.96614063
180ELK1_22589737_ChIP-Seq_MCF10A_Human0.96387556
181EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96278488
182TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95766289
183* OCT4_20526341_ChIP-Seq_ESCs_Human0.95451816
184PHF8_20622853_ChIP-Seq_HELA_Human0.95229266
185* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94769056
186NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90726682
187TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90390372
188* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89500992
189PHF8_20622854_ChIP-Seq_HELA_Human0.88685980
190GATA1_26923725_Chip-Seq_HPCs_Mouse0.86686840
191* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86459272
192SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86374314
193ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84933226
194SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83675647
195YY1_22570637_ChIP-Seq_MALME-3M_Human0.83282702

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.37335614
2MP0003283_abnormal_digestive_organ5.17140915
3MP0003878_abnormal_ear_physiology4.55254658
4MP0005377_hearing/vestibular/ear_phenot4.55254658
5MP0002822_catalepsy4.42143690
6MP0002102_abnormal_ear_morphology3.92628659
7MP0004957_abnormal_blastocyst_morpholog3.73776405
8MP0003111_abnormal_nucleus_morphology3.27896311
9MP0003806_abnormal_nucleotide_metabolis3.12573033
10MP0001968_abnormal_touch/_nociception3.08327592
11MP0010352_gastrointestinal_tract_polyps2.81978966
12MP0010094_abnormal_chromosome_stability2.67745452
13MP0003315_abnormal_perineum_morphology2.66452808
14MP0005410_abnormal_fertilization2.44932506
15MP0000462_abnormal_digestive_system2.40191415
16MP0010386_abnormal_urinary_bladder2.38669628
17MP0003787_abnormal_imprinting2.32086006
18MP0000537_abnormal_urethra_morphology2.30066744
19MP0003077_abnormal_cell_cycle2.29217938
20MP0003195_calcinosis2.29135789
21MP0008877_abnormal_DNA_methylation2.28656457
22MP0001986_abnormal_taste_sensitivity2.28543951
23MP0003718_maternal_effect2.28017494
24MP0005083_abnormal_biliary_tract2.27555959
25MP0000516_abnormal_urinary_system2.25206012
26MP0005367_renal/urinary_system_phenotyp2.25206012
27MP0005551_abnormal_eye_electrophysiolog2.21345831
28MP0001730_embryonic_growth_arrest2.18776581
29MP0005085_abnormal_gallbladder_physiolo2.13362280
30MP0008058_abnormal_DNA_repair2.08629538
31MP0008872_abnormal_physiological_respon2.04950140
32MP0003941_abnormal_skin_development2.03811877
33MP0005365_abnormal_bile_salt2.03058728
34MP0008932_abnormal_embryonic_tissue1.98473543
35MP0008004_abnormal_stomach_pH1.97831793
36MP0002876_abnormal_thyroid_physiology1.88386119
37MP0010234_abnormal_vibrissa_follicle1.80273411
38MP0002736_abnormal_nociception_after1.79715767
39MP0001501_abnormal_sleep_pattern1.71888106
40MP0000427_abnormal_hair_cycle1.70050293
41MP0006292_abnormal_olfactory_placode1.68462132
42MP0008057_abnormal_DNA_replication1.67490356
43MP0000490_abnormal_crypts_of1.67489045
44MP0000350_abnormal_cell_proliferation1.63972493
45MP0003123_paternal_imprinting1.59365005
46MP0005646_abnormal_pituitary_gland1.59204994
47MP0001929_abnormal_gametogenesis1.58588302
48MP0002210_abnormal_sex_determination1.54077083
49MP0005253_abnormal_eye_physiology1.53454910
50MP0002638_abnormal_pupillary_reflex1.52676469
51MP0000383_abnormal_hair_follicle1.50726035
52MP0005174_abnormal_tail_pigmentation1.50174369
53MP0006276_abnormal_autonomic_nervous1.48876170
54MP0002938_white_spotting1.47877126
55MP0004264_abnormal_extraembryonic_tissu1.47638539
56MP0004142_abnormal_muscle_tone1.46713299
57MP0000372_irregular_coat_pigmentation1.45304923
58* MP0003698_abnormal_male_reproductive1.44460075
59MP0002653_abnormal_ependyma_morphology1.44337127
60MP0003252_abnormal_bile_duct1.43539444
61MP0008007_abnormal_cellular_replicative1.43131680
62MP0005075_abnormal_melanosome_morpholog1.42565678
63MP0001145_abnormal_male_reproductive1.42519912
64MP0000477_abnormal_intestine_morphology1.41923131
65MP0004147_increased_porphyrin_level1.38430203
66MP0001849_ear_inflammation1.38197702
67MP0009840_abnormal_foam_cell1.37253432
68MP0005167_abnormal_blood-brain_barrier1.36658816
69MP0001984_abnormal_olfaction1.35413659
70MP0006072_abnormal_retinal_apoptosis1.34646774
71MP0002837_dystrophic_cardiac_calcinosis1.32547676
72MP0009745_abnormal_behavioral_response1.32087342
73MP0003866_abnormal_defecation1.30135179
74MP0003786_premature_aging1.30089104
75MP0002234_abnormal_pharynx_morphology1.29515505
76MP0008995_early_reproductive_senescence1.28892910
77MP0001905_abnormal_dopamine_level1.27654816
78MP0001697_abnormal_embryo_size1.24590828
79MP0001873_stomach_inflammation1.24304275
80MP0004019_abnormal_vitamin_homeostasis1.24153451
81MP0003880_abnormal_central_pattern1.22032128
82MP0001672_abnormal_embryogenesis/_devel1.21353474
83MP0005380_embryogenesis_phenotype1.21353474
84MP0004885_abnormal_endolymph1.20573868
85MP0000653_abnormal_sex_gland1.20221457
86MP0001764_abnormal_homeostasis1.19841564
87MP0005310_abnormal_salivary_gland1.19132447
88MP0005645_abnormal_hypothalamus_physiol1.16687363
89MP0002160_abnormal_reproductive_system1.16614969
90MP0002254_reproductive_system_inflammat1.16362762
91MP0005332_abnormal_amino_acid1.16158448
92MP0004742_abnormal_vestibular_system1.15538289
93MP0002085_abnormal_embryonic_tissue1.15148222
94MP0003186_abnormal_redox_activity1.13302391
95MP0003136_yellow_coat_color1.12969344
96MP0002080_prenatal_lethality1.12226421
97MP0009379_abnormal_foot_pigmentation1.12171607
98MP0009046_muscle_twitch1.11985314
99MP0002735_abnormal_chemical_nociception1.11515224
100MP0000230_abnormal_systemic_arterial1.11278048
101MP0005084_abnormal_gallbladder_morpholo1.10450091
102MP0005266_abnormal_metabolism1.09910114
103MP0005451_abnormal_body_composition1.09660168
104MP0000538_abnormal_urinary_bladder1.09075580
105MP0002086_abnormal_extraembryonic_tissu1.08955350
106MP0003119_abnormal_digestive_system1.08599099
107MP0004133_heterotaxia1.05974664
108MP0002796_impaired_skin_barrier1.05196911
109MP0001486_abnormal_startle_reflex1.05076486
110MP0002272_abnormal_nervous_system1.04426128
111MP0001765_abnormal_ion_homeostasis1.03991295
112MP0002132_abnormal_respiratory_system1.03241065
113MP0003984_embryonic_growth_retardation1.02716325
114MP0005389_reproductive_system_phenotype1.01216377
115MP0002084_abnormal_developmental_patter1.00970127
116MP0003011_delayed_dark_adaptation1.00593519
117MP0003567_abnormal_fetal_cardiomyocyte1.00251234
118MP0000569_abnormal_digit_pigmentation0.99734609
119MP0002088_abnormal_embryonic_growth/wei0.99307030
120MP0000470_abnormal_stomach_morphology0.98705659
121MP0001666_abnormal_nutrient_absorption0.97387667
122MP0000631_abnormal_neuroendocrine_gland0.96996020
123MP0005381_digestive/alimentary_phenotyp0.96342809
124MP0001970_abnormal_pain_threshold0.96066536
125MP0010678_abnormal_skin_adnexa0.94774430
126MP0001664_abnormal_digestion0.94401101
127MP0008875_abnormal_xenobiotic_pharmacok0.93981723
128MP0002161_abnormal_fertility/fecundity0.90674587
129MP0004197_abnormal_fetal_growth/weight/0.90314449
130MP0002557_abnormal_social/conspecific_i0.89929440
131MP0005386_behavior/neurological_phenoty0.89864011
132MP0004924_abnormal_behavior0.89864011
133MP0001485_abnormal_pinna_reflex0.89837836
134MP0001502_abnormal_circadian_rhythm0.89520014
135MP0010307_abnormal_tumor_latency0.88107977
136MP0005187_abnormal_penis_morphology0.86299868
137MP0005394_taste/olfaction_phenotype0.84986448
138MP0005499_abnormal_olfactory_system0.84986448
139MP0005670_abnormal_white_adipose0.82504331
140MP0000026_abnormal_inner_ear0.80208612
141MP0006035_abnormal_mitochondrial_morpho0.79872275
142MP0001963_abnormal_hearing_physiology0.79538939
143MP0010329_abnormal_lipoprotein_level0.79112921
144MP0002277_abnormal_respiratory_mucosa0.77923310
145MP0001293_anophthalmia0.77131055
146MP0002111_abnormal_tail_morphology0.76254104
147MP0005395_other_phenotype0.74912395
148MP0001188_hyperpigmentation0.74026738
149MP0003638_abnormal_response/metabolism_0.73429079
150MP0003705_abnormal_hypodermis_morpholog0.73156120
151MP0003937_abnormal_limbs/digits/tail_de0.73021709
152MP0002928_abnormal_bile_duct0.72765596
153MP0004043_abnormal_pH_regulation0.72101742
154MP0005501_abnormal_skin_physiology0.70822955
155MP0002019_abnormal_tumor_incidence0.70426729
156MP0000313_abnormal_cell_death0.70159585
157MP0003936_abnormal_reproductive_system0.69925721
158MP0001663_abnormal_digestive_system0.68745196
159MP0001756_abnormal_urination0.68520214
160MP0010155_abnormal_intestine_physiology0.68168680
161MP0003646_muscle_fatigue0.67053143
162MP0009672_abnormal_birth_weight0.64524137
163MP0009643_abnormal_urine_homeostasis0.63750027
164MP0001919_abnormal_reproductive_system0.63021974
165MP0006036_abnormal_mitochondrial_physio0.61713850
166MP0005636_abnormal_mineral_homeostasis0.56631008
167MP0009053_abnormal_anal_canal0.55728980
168MP0002751_abnormal_autonomic_nervous0.55700865
169MP0001661_extended_life_span0.54165563
170MP0001542_abnormal_bone_strength0.53782134
171MP0000358_abnormal_cell_content/0.52982692
172MP0008789_abnormal_olfactory_epithelium0.52441805

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the 1st metacarpal (HP:0010009)6.26309404
2Short phalanx of the thumb (HP:0009660)4.75965066
3Breast hypoplasia (HP:0003187)4.31248916
4Molar tooth sign on MRI (HP:0002419)4.27909013
5Abnormality of midbrain morphology (HP:0002418)4.27909013
6Pancreatic cysts (HP:0001737)4.25506721
7Pancreatic fibrosis (HP:0100732)4.25394692
8Abnormal respiratory motile cilium morphology (HP:0005938)3.93589674
9Abnormal respiratory epithelium morphology (HP:0012253)3.93589674
10True hermaphroditism (HP:0010459)3.91761924
11Carpal bone hypoplasia (HP:0001498)3.80787650
12Decreased circulating renin level (HP:0003351)3.75828628
13Aplasia/hypoplasia of the humerus (HP:0006507)3.74564197
14Abnormal ciliary motility (HP:0012262)3.68396318
15Abnormality of the proximal phalanges of the hand (HP:0009834)3.65126340
16Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.57797940
17Impulsivity (HP:0100710)3.57580575
18Septate vagina (HP:0001153)3.57032182
19Medial flaring of the eyebrow (HP:0010747)3.47369363
20Abnormal respiratory motile cilium physiology (HP:0012261)3.46705376
21Nephronophthisis (HP:0000090)3.41254983
22Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.40316213
23Short 1st metacarpal (HP:0010034)3.40316213
24Short humerus (HP:0005792)3.34876099
25Birth length less than 3rd percentile (HP:0003561)3.34222146
26Abnormality of the 2nd finger (HP:0004100)3.32568828
27Abnormality of the distal phalanx of the thumb (HP:0009617)3.28496247
28Short hallux (HP:0010109)3.22293549
29Cystic liver disease (HP:0006706)3.21910168
30Patellar aplasia (HP:0006443)3.18730702
31Aplasia/Hypoplasia of the hallux (HP:0008362)3.14946756
32Rough bone trabeculation (HP:0100670)3.13167813
33Abnormality of cells of the erythroid lineage (HP:0012130)3.10164783
34Abnormality of the renal medulla (HP:0100957)3.09930429
35Chronic hepatic failure (HP:0100626)3.08334668
36Abnormal rod and cone electroretinograms (HP:0008323)3.07489190
37Breech presentation (HP:0001623)3.04409926
38Aplasia/Hypoplasia of the patella (HP:0006498)2.98194530
39Abnormality of the renal cortex (HP:0011035)2.94941360
40Congenital stationary night blindness (HP:0007642)2.91890445
41Rhinitis (HP:0012384)2.90457558
42Symphalangism affecting the phalanges of the hand (HP:0009773)2.90005066
43Attenuation of retinal blood vessels (HP:0007843)2.88060289
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.86181426
45Abnormality of carpal bone ossification (HP:0006257)2.84659255
46Tubular atrophy (HP:0000092)2.83881245
47Congenital primary aphakia (HP:0007707)2.83473291
48Gait imbalance (HP:0002141)2.82387201
49Absent radius (HP:0003974)2.81187719
50Abnormality of the phalanges of the hallux (HP:0010057)2.78930562
51Abnormal drinking behavior (HP:0030082)2.78847428
52Polydipsia (HP:0001959)2.78847428
53Abnormal number of erythroid precursors (HP:0012131)2.77875307
54Abnormality of renin-angiotensin system (HP:0000847)2.71936282
55Hypoglycemic seizures (HP:0002173)2.71925023
56Nephrogenic diabetes insipidus (HP:0009806)2.68153157
57Hypoplasia of the radius (HP:0002984)2.67411080
58Short middle phalanx of finger (HP:0005819)2.67298573
59Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.66959341
60Irregular epiphyses (HP:0010582)2.65221824
61Abolished electroretinogram (ERG) (HP:0000550)2.63441151
62Absent forearm bone (HP:0003953)2.61127022
63Aplasia involving forearm bones (HP:0009822)2.61127022
64Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.59498860
65Biliary tract neoplasm (HP:0100574)2.59333399
66Type II lissencephaly (HP:0007260)2.58958484
67Colon cancer (HP:0003003)2.54216291
68Short tibia (HP:0005736)2.53540487
69Hyperactive renin-angiotensin system (HP:0000841)2.53248093
70Short thumb (HP:0009778)2.52854349
71Bronchiectasis (HP:0002110)2.51162561
72Decreased central vision (HP:0007663)2.50127216
73Ependymoma (HP:0002888)2.48241723
74Bony spicule pigmentary retinopathy (HP:0007737)2.47810242
75Flat acetabular roof (HP:0003180)2.47092574
76Flat capital femoral epiphysis (HP:0003370)2.46121605
77Aplasia/Hypoplasia of the tongue (HP:0010295)2.43665142
78Microretrognathia (HP:0000308)2.43108380
79Bile duct proliferation (HP:0001408)2.43072950
80Abnormal biliary tract physiology (HP:0012439)2.43072950
81Sandal gap (HP:0001852)2.42526122
82Abnormality of the anterior horn cell (HP:0006802)2.41450193
83Degeneration of anterior horn cells (HP:0002398)2.41450193
84Cerebral hypomyelination (HP:0006808)2.41222088
85Rectovaginal fistula (HP:0000143)2.40700076
86Rectal fistula (HP:0100590)2.40700076
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.40656412
88Abnormal protein N-linked glycosylation (HP:0012347)2.40656412
89Abnormal protein glycosylation (HP:0012346)2.40656412
90Abnormal glycosylation (HP:0012345)2.40656412
91Occipital encephalocele (HP:0002085)2.40286248
92Sclerocornea (HP:0000647)2.39118081
93Proximal placement of thumb (HP:0009623)2.38471926
94Right ventricular cardiomyopathy (HP:0011663)2.37815352
95Shawl scrotum (HP:0000049)2.35195779
96Genital tract atresia (HP:0001827)2.34430358
97Abnormality of the labia minora (HP:0012880)2.33752996
98Vertebral clefting (HP:0008428)2.33078297
99Stenosis of the external auditory canal (HP:0000402)2.32636636
100Aplasia/Hypoplasia of the tibia (HP:0005772)2.31334348
101Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28930304
102Reticulocytopenia (HP:0001896)2.28410156
103Abnormal trabecular bone morphology (HP:0100671)2.27622622
104Pendular nystagmus (HP:0012043)2.26329737
105Polyuria (HP:0000103)2.25817315
106Hyperaldosteronism (HP:0000859)2.25545003
107Chronic bronchitis (HP:0004469)2.24797265
108Relative macrocephaly (HP:0004482)2.24369162
109Abnormality of small intestinal villus morphology (HP:0011472)2.23877494
110Villous atrophy (HP:0011473)2.23877494
111Abnormal ossification of hand bones (HP:0005921)2.23224087
112Hyperventilation (HP:0002883)2.20212739
113Male pseudohermaphroditism (HP:0000037)2.19574993
114Abnormality of the middle phalanges of the toes (HP:0010183)2.18802019
115Anencephaly (HP:0002323)2.18620389
116Vaginal atresia (HP:0000148)2.18612703
117Cupped ribs (HP:0000887)2.18487445
118Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.15898887
119Aplasia/Hypoplasia of the spleen (HP:0010451)2.15266987
120Deviation of the thumb (HP:0009603)2.13439804
121Neoplasm of the pancreas (HP:0002894)2.12855437
122Ileus (HP:0002595)2.12261184
123Asplenia (HP:0001746)2.11318587
124Genu varum (HP:0002970)2.11175429
125Postaxial foot polydactyly (HP:0001830)2.11108038
126Abdominal situs inversus (HP:0003363)2.10740488
127Abnormality of abdominal situs (HP:0011620)2.10740488
128Abnormal tarsal ossification (HP:0008369)2.10315494
129Oral leukoplakia (HP:0002745)2.09119355
130Absent thumb (HP:0009777)2.07694778
131Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.07447216
132Abnormal hand bone ossification (HP:0010660)2.07162751
133Macrocytic anemia (HP:0001972)2.06132491
134Metabolic alkalosis (HP:0200114)2.06089586
135Aplasia/Hypoplasia of the ulna (HP:0006495)2.05273372
136Stomach cancer (HP:0012126)2.04239641
137Megaloblastic anemia (HP:0001889)2.03318055
138Supernumerary spleens (HP:0009799)2.03254742
139Acute necrotizing encephalopathy (HP:0006965)2.01440118
140Flattened epiphyses (HP:0003071)2.01204570
141Trismus (HP:0000211)2.01120190
1423-Methylglutaconic aciduria (HP:0003535)2.00549534
143Vaginal fistula (HP:0004320)2.00062588
144Overlapping toe (HP:0001845)1.98923840
145Azoospermia (HP:0000027)1.97980971
146Abnormality of renal excretion (HP:0011036)1.97074063
147Abnormal cartilage morphology (HP:0002763)1.96838455
148Absent/shortened dynein arms (HP:0200106)1.96833804
149Dynein arm defect of respiratory motile cilia (HP:0012255)1.96833804
150Congenital hepatic fibrosis (HP:0002612)1.95757097
151Mitochondrial inheritance (HP:0001427)1.95270253
152Aplasia/hypoplasia of the femur (HP:0005613)1.94500682
153Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.93898040
154Congenital sensorineural hearing impairment (HP:0008527)1.93672685
155Retinitis pigmentosa (HP:0000510)1.93672172
156Short ribs (HP:0000773)1.93666763
157Abnormal spermatogenesis (HP:0008669)1.92449912
158Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92390334
159Abnormal biliary tract morphology (HP:0012440)1.92202712
160Furrowed tongue (HP:0000221)1.91253078
161Type I transferrin isoform profile (HP:0003642)1.89308894
162Abnormality of the fetal cardiovascular system (HP:0010948)1.88093053
163Abnormal umbilical cord blood vessels (HP:0011403)1.88093053
164Single umbilical artery (HP:0001195)1.88093053
165Hyperglycinemia (HP:0002154)1.87780720
166Absent phalangeal crease (HP:0006109)1.87662741
167Keratoconus (HP:0000563)1.87490343
168Increased corneal curvature (HP:0100692)1.87490343
169Acute encephalopathy (HP:0006846)1.86862337
170Hypokalemic alkalosis (HP:0001949)1.86156830
171Poor coordination (HP:0002370)1.85586884
172Postaxial hand polydactyly (HP:0001162)1.84910323
173Cerebellar dysplasia (HP:0007033)1.84439002
174Abnormal urine output (HP:0012590)1.84294902
175Hypothermia (HP:0002045)1.83667117
176Renal cortical cysts (HP:0000803)1.82302854
177Lissencephaly (HP:0001339)1.80803186
178Increased CSF lactate (HP:0002490)1.80780127
179Tubulointerstitial nephritis (HP:0001970)1.76919140
180Progressive macrocephaly (HP:0004481)1.76460040
181Alkalosis (HP:0001948)1.75374110
182Lipid accumulation in hepatocytes (HP:0006561)1.72819147
183Hypoplasia of the pons (HP:0012110)1.72744317
184Hypokalemia (HP:0002900)1.71309654
185Abnormal mitochondria in muscle tissue (HP:0008316)1.69673842
186Abnormality of the pons (HP:0007361)1.69378167
187Preaxial hand polydactyly (HP:0001177)1.68872238
188Facial hemangioma (HP:0000329)1.68422115
189Optic disc pallor (HP:0000543)1.67377597
190Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65835202
191Aplasia/Hypoplasia of the fovea (HP:0008060)1.65697461
192Hypoplasia of the fovea (HP:0007750)1.65697461
193Symptomatic seizures (HP:0011145)1.65262586

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.58634811
2WEE14.34965994
3BUB14.16688405
4EPHA23.94425013
5ADRBK23.91865515
6MAP4K23.57161905
7STK393.17138771
8TAOK32.72612192
9PNCK2.64564544
10OXSR12.63248500
11TESK12.53468739
12MET2.50253341
13STK162.50192272
14PDK42.44526463
15PDK32.44526463
16WNK32.35010008
17NEK12.33129861
18NUAK12.31854659
19NEK22.30941354
20GRK12.22591108
21SRPK12.22310165
22EIF2AK12.15772792
23PLK42.13665311
24TTK2.12609941
25BMPR1B2.09800404
26CASK1.88696072
27BRSK21.88544241
28PDK21.81793318
29BRAF1.75707409
30TSSK61.73836847
31TRIM281.72223384
32MAPK131.70924612
33TXK1.68085713
34RPS6KB21.67490754
35NME21.64362542
36CDC71.62689594
37PLK11.61900243
38ARAF1.61667532
39NME11.58585283
40TESK21.56565417
41MAP2K21.55395803
42CAMKK21.54457382
43MAP3K41.53507141
44EIF2AK31.50621149
45PAK41.40767327
46NTRK31.39834542
47TIE11.33818302
48AKT31.32127862
49PTK2B1.25022154
50AURKB1.20857970
51MST41.16078783
52PLK31.15852745
53MAPK151.13826917
54INSRR1.13172034
55ADRBK11.11767418
56MAP3K81.11653507
57ICK1.10505604
58PIM21.08353642
59TEC1.06166349
60PRKCI1.04052861
61PAK31.03959507
62PINK11.02754272
63PIK3CA0.98198540
64BRSK10.98169508
65MAP3K70.97871975
66PAK10.97754256
67MAP3K120.95610854
68CDK70.94814433
69TNIK0.94578055
70AURKA0.93294449
71MAP2K70.92220015
72VRK20.91605849
73TAF10.91344883
74CHEK20.88006930
75MAPKAPK30.87728691
76ERBB40.85087527
77PRKCE0.80927304
78CCNB10.76520309
79IKBKB0.75339950
80STK38L0.75289916
81ZAK0.74526990
82MAP3K110.72686527
83ALK0.71451479
84STK110.71232246
85ATR0.70535887
86CHEK10.68639906
87FRK0.66880852
88PASK0.66800280
89PRKD20.65722199
90MUSK0.64603789
91PRKCQ0.64230648
92FGFR20.64194484
93DYRK30.63979896
94ACVR1B0.61748762
95CSNK1G20.61346580
96PRKCG0.61209065
97CSNK1G10.60991946
98PHKG20.60875983
99PHKG10.60875983
100KIT0.60595200
101FER0.59798331
102ERBB20.59019935
103IRAK10.57501097
104CAMK2A0.57468382
105DAPK20.53845612
106DYRK1A0.53661199
107SCYL20.53080399
108CSNK1G30.51858812
109STK100.51351646
110IKBKE0.50687794
111BCKDK0.49859205
112CSNK2A20.49319974
113MARK10.49069044
114NLK0.48882830
115PRKACA0.47458652
116TLK10.46791523
117LYN0.46660207
118CDK20.46523459
119CLK10.46442741
120EPHA40.46399023
121VRK10.45194796
122CSNK2A10.45149050
123BCR0.44021816
124CSNK1E0.43546225
125PRKCA0.43440682
126MATK0.41696362
127TBK10.40991439
128EIF2AK20.40385043
129TNK20.39625270
130TAOK20.39298581
131CSF1R0.39171971
132CSNK1A1L0.38826093
133BRD40.38776730
134CSNK1A10.38749595
135DYRK20.37923036
136ABL10.37876801
137GRK60.36967626
138IRAK30.35629564
139EPHB20.35516242
140MAPKAPK50.34438917
141EPHA30.33849805
142DAPK30.33608877
143GRK70.33580544
144PRKCZ0.32973345
145ITK0.32428669
146LIMK10.31899348
147PLK20.31512426
148CAMK1G0.30940926
149CDK10.30937284
150CAMK2D0.30037032
151MKNK10.29947149
152IGF1R0.29906457
153ABL20.29861342
154PRKG10.29637756
155PRKAA10.29538990
156CDK40.29270894
157CAMK2B0.28017710
158ATM0.27511564
159MAP2K10.27489363
160KDR0.27004068
161CDK60.25018952
162CAMK2G0.23983677
163WNK40.23490198
164PRKAA20.23321282
165CAMKK10.22722363
166PBK0.22532064
167MAP3K90.20382869
168PIM10.19635642
169MKNK20.19325554
170MAP2K60.19080051
171LATS20.18225552
172CDK120.17660760

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.49519352
2Proteasome_Homo sapiens_hsa030503.73473743
3RNA polymerase_Homo sapiens_hsa030203.53768710
4DNA replication_Homo sapiens_hsa030303.34761731
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22240216
6Ribosome_Homo sapiens_hsa030103.02285186
7Sulfur relay system_Homo sapiens_hsa041222.97093256
8Mismatch repair_Homo sapiens_hsa034302.88210653
9Caffeine metabolism_Homo sapiens_hsa002322.70691885
10RNA transport_Homo sapiens_hsa030132.67912761
11Nitrogen metabolism_Homo sapiens_hsa009102.67911521
12Spliceosome_Homo sapiens_hsa030402.46365405
13Pyrimidine metabolism_Homo sapiens_hsa002402.45801334
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.34709944
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33503440
16Homologous recombination_Homo sapiens_hsa034402.22733720
17Phototransduction_Homo sapiens_hsa047442.19122422
18Fructose and mannose metabolism_Homo sapiens_hsa000511.98867269
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.90709088
20Base excision repair_Homo sapiens_hsa034101.90487313
21Vitamin B6 metabolism_Homo sapiens_hsa007501.82657099
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.82497844
23Oxidative phosphorylation_Homo sapiens_hsa001901.81228638
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77065325
25Nucleotide excision repair_Homo sapiens_hsa034201.76500579
26Huntingtons disease_Homo sapiens_hsa050161.72767495
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70936411
28Mineral absorption_Homo sapiens_hsa049781.68912876
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67057456
30Tryptophan metabolism_Homo sapiens_hsa003801.60784173
31One carbon pool by folate_Homo sapiens_hsa006701.57255444
32Parkinsons disease_Homo sapiens_hsa050121.55569430
33Cell cycle_Homo sapiens_hsa041101.51915250
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51833052
35Fanconi anemia pathway_Homo sapiens_hsa034601.50766989
36Regulation of autophagy_Homo sapiens_hsa041401.46606081
37Peroxisome_Homo sapiens_hsa041461.46492481
38Purine metabolism_Homo sapiens_hsa002301.43766239
39Nicotine addiction_Homo sapiens_hsa050331.37644832
40* Ether lipid metabolism_Homo sapiens_hsa005651.35253682
41Basal transcription factors_Homo sapiens_hsa030221.33991968
42Glutathione metabolism_Homo sapiens_hsa004801.30648601
43Fatty acid degradation_Homo sapiens_hsa000711.27953748
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.24890575
45Carbon metabolism_Homo sapiens_hsa012001.21779938
46Pentose phosphate pathway_Homo sapiens_hsa000301.21560748
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.19234222
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19090268
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14658920
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13723177
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13474022
52Taste transduction_Homo sapiens_hsa047421.12626625
53Olfactory transduction_Homo sapiens_hsa047401.09931476
54Protein export_Homo sapiens_hsa030601.08443584
55Non-homologous end-joining_Homo sapiens_hsa034501.06349776
56Primary immunodeficiency_Homo sapiens_hsa053401.03963002
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03693264
58Folate biosynthesis_Homo sapiens_hsa007901.03167632
59mRNA surveillance pathway_Homo sapiens_hsa030150.99853908
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99649028
61RNA degradation_Homo sapiens_hsa030180.96873586
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95564336
63p53 signaling pathway_Homo sapiens_hsa041150.95142982
64Asthma_Homo sapiens_hsa053100.94628612
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92114933
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.91865463
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90574623
68Alzheimers disease_Homo sapiens_hsa050100.89652544
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89403822
70Selenocompound metabolism_Homo sapiens_hsa004500.89239892
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85892442
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85452243
73Biosynthesis of amino acids_Homo sapiens_hsa012300.85023249
74ABC transporters_Homo sapiens_hsa020100.82873918
75Oocyte meiosis_Homo sapiens_hsa041140.81742268
76Galactose metabolism_Homo sapiens_hsa000520.81014794
77Chemical carcinogenesis_Homo sapiens_hsa052040.79819505
78* Metabolic pathways_Homo sapiens_hsa011000.72473908
79Morphine addiction_Homo sapiens_hsa050320.72460613
80Epstein-Barr virus infection_Homo sapiens_hsa051690.71899362
81Insulin secretion_Homo sapiens_hsa049110.71764184
82Tight junction_Homo sapiens_hsa045300.70130548
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69048463
84Cardiac muscle contraction_Homo sapiens_hsa042600.68333078
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66734300
86Sphingolipid metabolism_Homo sapiens_hsa006000.64802860
87Salivary secretion_Homo sapiens_hsa049700.63812461
88Fatty acid metabolism_Homo sapiens_hsa012120.62495661
89Ovarian steroidogenesis_Homo sapiens_hsa049130.62441044
90Tyrosine metabolism_Homo sapiens_hsa003500.59511725
91* Pancreatic secretion_Homo sapiens_hsa049720.58590035
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58220665
93Systemic lupus erythematosus_Homo sapiens_hsa053220.57145801
94Type I diabetes mellitus_Homo sapiens_hsa049400.54849151
95Vitamin digestion and absorption_Homo sapiens_hsa049770.54252384
96Fatty acid elongation_Homo sapiens_hsa000620.53975596
97Glycerolipid metabolism_Homo sapiens_hsa005610.53270035
98* Glycerophospholipid metabolism_Homo sapiens_hsa005640.51985509
99Phenylalanine metabolism_Homo sapiens_hsa003600.51927808
100Collecting duct acid secretion_Homo sapiens_hsa049660.51738282
101Pyruvate metabolism_Homo sapiens_hsa006200.50113143
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48307929
103Calcium signaling pathway_Homo sapiens_hsa040200.47761599
104Graft-versus-host disease_Homo sapiens_hsa053320.47208995
105Hedgehog signaling pathway_Homo sapiens_hsa043400.46490370
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45445787
107Allograft rejection_Homo sapiens_hsa053300.44958257
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.43532650
109Antigen processing and presentation_Homo sapiens_hsa046120.43015654
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42323747
111Autoimmune thyroid disease_Homo sapiens_hsa053200.41411517
112Steroid biosynthesis_Homo sapiens_hsa001000.40921205
113Retinol metabolism_Homo sapiens_hsa008300.40803694
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40566675
115* Arachidonic acid metabolism_Homo sapiens_hsa005900.39049247
116Serotonergic synapse_Homo sapiens_hsa047260.39032175
117Propanoate metabolism_Homo sapiens_hsa006400.38308475
118Arginine and proline metabolism_Homo sapiens_hsa003300.37673716
119Starch and sucrose metabolism_Homo sapiens_hsa005000.34509272
120* Fat digestion and absorption_Homo sapiens_hsa049750.34288650
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.34222319
122Histidine metabolism_Homo sapiens_hsa003400.33366766
123Butanoate metabolism_Homo sapiens_hsa006500.32986229
124* Linoleic acid metabolism_Homo sapiens_hsa005910.30268705
125Thyroid cancer_Homo sapiens_hsa052160.26130120
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26075908
127Circadian rhythm_Homo sapiens_hsa047100.24048321
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21660135
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20923814
130* alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18903530
131Renin-angiotensin system_Homo sapiens_hsa046140.18347569
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16868422
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15681153
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.14700690
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14669983
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12435055
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11604497
138Legionellosis_Homo sapiens_hsa051340.11481110
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.11281502
140Viral carcinogenesis_Homo sapiens_hsa052030.11275865
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11237133
142beta-Alanine metabolism_Homo sapiens_hsa004100.10217810

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