PKP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cardiac muscle cell apoptotic process (GO:0010667)6.28364719
2sarcomere organization (GO:0045214)6.20111479
3cardiac myofibril assembly (GO:0055003)5.96850279
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.53826562
5tricarboxylic acid cycle (GO:0006099)5.39463132
6cardiac chamber formation (GO:0003207)5.25261906
7regulation of cardiac muscle cell contraction (GO:0086004)5.18990536
8carnitine shuttle (GO:0006853)4.94984668
9myofibril assembly (GO:0030239)4.86807079
10fatty acid transmembrane transport (GO:1902001)4.86231609
11* bundle of His cell to Purkinje myocyte communication (GO:0086069)4.83538971
12negative regulation of potassium ion transmembrane transport (GO:1901380)4.79417663
13lysine catabolic process (GO:0006554)4.77219531
14lysine metabolic process (GO:0006553)4.77219531
15* cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.70873618
16cardiac muscle cell development (GO:0055013)4.69710082
17relaxation of cardiac muscle (GO:0055119)4.57022810
18cardiac muscle contraction (GO:0060048)4.53331857
19positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.49012585
20negative regulation of striated muscle cell apoptotic process (GO:0010664)4.47082290
21regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.45964861
22* regulation of heart rate (GO:0002027)4.41733834
23cardiac cell development (GO:0055006)4.39633865
242-oxoglutarate metabolic process (GO:0006103)4.39572070
25* ventricular cardiac muscle cell action potential (GO:0086005)4.38985918
26fatty acid beta-oxidation (GO:0006635)4.35624691
27atrial septum morphogenesis (GO:0060413)4.30057266
28cardiac ventricle formation (GO:0003211)4.21154385
29* cardiac muscle tissue morphogenesis (GO:0055008)4.15553586
30regulation of cell communication by electrical coupling (GO:0010649)4.14520335
31actin-myosin filament sliding (GO:0033275)4.13199654
32muscle filament sliding (GO:0030049)4.13199654
33regulation of sequestering of triglyceride (GO:0010889)4.11282088
34regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.09254861
35cardiac muscle hypertrophy (GO:0003300)4.05755527
36actomyosin structure organization (GO:0031032)4.02094184
37regulation of ATPase activity (GO:0043462)3.99828699
38regulation of ATP catabolic process (GO:1903289)3.99828699
39heart trabecula formation (GO:0060347)3.98430445
40aspartate family amino acid catabolic process (GO:0009068)3.98365412
41glyoxylate metabolic process (GO:0046487)3.97696072
42* cell communication by electrical coupling (GO:0010644)3.95860735
43* cardiac muscle cell action potential (GO:0086001)3.94558068
44cardiac right ventricle morphogenesis (GO:0003215)3.93968796
45* ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.93696312
46cardiac muscle hypertrophy in response to stress (GO:0014898)3.91348873
47muscle hypertrophy in response to stress (GO:0003299)3.91348873
48cardiac muscle adaptation (GO:0014887)3.91348873
49fatty acid oxidation (GO:0019395)3.89128977
50regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.88933099
51regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.88284829
52regulation of cardiac muscle contraction (GO:0055117)3.84839551
53lipid oxidation (GO:0034440)3.80354860
54adrenergic receptor signaling pathway (GO:0071875)3.80249137
55striated muscle hypertrophy (GO:0014897)3.77697786
56regulation of acyl-CoA biosynthetic process (GO:0050812)3.76537167
57carnitine transmembrane transport (GO:1902603)3.76440390
58* cardiac muscle cell action potential involved in contraction (GO:0086002)3.73398154
59fatty acid catabolic process (GO:0009062)3.71648156
60acetyl-CoA metabolic process (GO:0006084)3.71402565
61atrioventricular valve morphogenesis (GO:0003181)3.70430254
62L-phenylalanine metabolic process (GO:0006558)3.68744049
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.68744049
64regulation of transforming growth factor beta2 production (GO:0032909)3.68101279
65* muscle tissue morphogenesis (GO:0060415)3.67735867
66outflow tract septum morphogenesis (GO:0003148)3.67131088
67positive regulation of heart rate (GO:0010460)3.65442138
68regulation of fatty acid oxidation (GO:0046320)3.63361520
69regulation of coenzyme metabolic process (GO:0051196)3.62933757
70regulation of cofactor metabolic process (GO:0051193)3.62933757
71regulation of cardioblast differentiation (GO:0051890)3.61633836
72* cardiac conduction (GO:0061337)3.59466646
73triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.58631449
74amino-acid betaine transport (GO:0015838)3.58405380
75carnitine transport (GO:0015879)3.58405380
76actin-mediated cell contraction (GO:0070252)3.57245844
77* regulation of heart contraction (GO:0008016)3.56849927
78adult heart development (GO:0007512)3.56424392
79amino-acid betaine metabolic process (GO:0006577)3.53453115
80kynurenine metabolic process (GO:0070189)3.52947424
81short-chain fatty acid metabolic process (GO:0046459)3.52837480
82actin filament-based movement (GO:0030048)3.52044232
83embryonic heart tube development (GO:0035050)3.50407911
84positive regulation of fatty acid oxidation (GO:0046321)3.48788126
85branched-chain amino acid catabolic process (GO:0009083)3.48771106
86plasma membrane repair (GO:0001778)3.48081975
87NADH metabolic process (GO:0006734)3.46219710
88regulation of actin filament-based movement (GO:1903115)3.45667639
89positive regulation of heart contraction (GO:0045823)3.43973390
90cardiac muscle tissue development (GO:0048738)3.42653949
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.42481172
92L-phenylalanine catabolic process (GO:0006559)3.42481172
93oxidative phosphorylation (GO:0006119)3.40996716
94carnitine metabolic process (GO:0009437)3.39152912
95regulation of the force of heart contraction (GO:0002026)3.38961190
96negative regulation of myotube differentiation (GO:0010832)3.37834710
97regulation of skeletal muscle contraction (GO:0014819)3.37777290
98fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.37363693
99regulation of triglyceride catabolic process (GO:0010896)3.35937074
100monocarboxylic acid catabolic process (GO:0072329)3.35744708
101positive regulation of fatty acid beta-oxidation (GO:0032000)3.33844275
102cellular ketone body metabolic process (GO:0046950)3.32809094
103regulation of sarcomere organization (GO:0060297)3.31566007
104regulation of cardiac muscle cell apoptotic process (GO:0010665)3.30773588
105muscle hypertrophy (GO:0014896)3.30173786
106* cell communication involved in cardiac conduction (GO:0086065)3.28707545
107* desmosome organization (GO:0002934)3.28428926
108cysteine metabolic process (GO:0006534)3.27754778
109negative regulation of fatty acid biosynthetic process (GO:0045717)3.26012767
110detection of calcium ion (GO:0005513)3.25393483
111endocardial cushion development (GO:0003197)3.23740348
112positive regulation of action potential (GO:0045760)3.23027840
113positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.22254445
114positive regulation of ATPase activity (GO:0032781)3.21817777
115positive regulation of ATP catabolic process (GO:1903291)3.21817777
116oxaloacetate metabolic process (GO:0006107)3.21742528
117mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.21537490
118positive regulation of cardiac muscle tissue development (GO:0055025)3.20330151
119alpha-linolenic acid metabolic process (GO:0036109)3.20219216
120epithelial cell-cell adhesion (GO:0090136)3.20142352
121sarcoplasmic reticulum calcium ion transport (GO:0070296)3.17355096
122positive regulation of cardiac muscle cell differentiation (GO:2000727)3.17293789
123phospholipid homeostasis (GO:0055091)3.17115822
124ventricular cardiac muscle cell development (GO:0055015)3.16640458
125striated muscle contraction (GO:0006941)3.14975591
126heart process (GO:0003015)3.12027132
127heart contraction (GO:0060047)3.12027132
128positive regulation of cardiac muscle cell proliferation (GO:0060045)3.10059370
129serine family amino acid catabolic process (GO:0009071)3.09961617
130regulation of sulfur metabolic process (GO:0042762)3.08869627
131branched-chain amino acid metabolic process (GO:0009081)3.07239289
132regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.06670696
133tricarboxylic acid metabolic process (GO:0072350)3.06607587
134positive regulation of cardiac muscle tissue growth (GO:0055023)3.05669397
135negative regulation of fibrinolysis (GO:0051918)3.02930436
136fatty acid homeostasis (GO:0055089)3.02878240
137regulation of cardiac muscle cell proliferation (GO:0060043)3.01695394
138sulfur amino acid catabolic process (GO:0000098)3.01483456
139negative regulation of hormone biosynthetic process (GO:0032353)3.01279041
140ATP synthesis coupled proton transport (GO:0015986)2.99643751
141energy coupled proton transport, down electrochemical gradient (GO:0015985)2.99643751
142regulation of cardiac muscle tissue development (GO:0055024)2.99133776
143homocysteine metabolic process (GO:0050667)2.98685211
144aromatic amino acid family catabolic process (GO:0009074)2.98422027
145biotin metabolic process (GO:0006768)2.97929272
146regulation of relaxation of muscle (GO:1901077)2.97276430
147dicarboxylic acid biosynthetic process (GO:0043650)2.97174821
148response to caffeine (GO:0031000)2.96968613
149regulation of striated muscle contraction (GO:0006942)2.96266837
150regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.94491639
151striated muscle cell development (GO:0055002)2.92578069
152relaxation of muscle (GO:0090075)2.92213675
153regulation of striated muscle cell apoptotic process (GO:0010662)2.92211938
154cardiac septum development (GO:0003279)2.92105888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.69927653
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.54391894
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.02331749
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.76147087
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.26231980
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.98339738
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.41559971
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.36292939
9ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.20889591
10CDX2_19796622_ChIP-Seq_MESCs_Mouse3.01758991
11CLOCK_20551151_ChIP-Seq_293T_Human2.96276793
12* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.89774956
13* EP300_21415370_ChIP-Seq_HL-1_Mouse2.88547213
14ZNF263_19887448_ChIP-Seq_K562_Human2.66942053
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56587935
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.49041361
17* TBX20_22328084_ChIP-Seq_HEART_Mouse2.27176273
18* TBX20_22080862_ChIP-Seq_HEART_Mouse2.27176273
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.13447302
20VDR_22108803_ChIP-Seq_LS180_Human2.10441072
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97316237
22STAT3_1855785_ChIP-Seq_MESCs_Mouse1.97045114
23* CDX2_20551321_ChIP-Seq_CACO-2_Human1.96952589
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95179405
25* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87905892
26NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.86331555
27SMAD3_21741376_ChIP-Seq_HESCs_Human1.80338630
28* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.76365962
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.73184966
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.72422042
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.67484135
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.65402048
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.63764045
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61643290
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60914758
36SOX2_20726797_ChIP-Seq_SW620_Human1.59852345
37* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57903860
38GATA4_21415370_ChIP-Seq_HL-1_Mouse1.56118647
39PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.55653781
40FOXM1_26456572_ChIP-Seq_MCF-7_Human1.54184696
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48725077
42TCF4_18268006_ChIP-ChIP_LS174T_Human1.46127117
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.43677172
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41644056
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.41556444
46* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41276158
47ATF3_27146783_Chip-Seq_COLON_Human1.39349085
48AHR_22903824_ChIP-Seq_MCF-7_Human1.38720304
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37996665
50SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37907751
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35474387
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32809206
53NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.32398851
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32239612
55CDX2_22108803_ChIP-Seq_LS180_Human1.32120981
56GBX2_23144817_ChIP-Seq_PC3_Human1.31848382
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31070363
58SMAD4_21741376_ChIP-Seq_HESCs_Human1.29476116
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29034350
60GATA1_22025678_ChIP-Seq_K562_Human1.28218992
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.28127204
62SMAD4_21799915_ChIP-Seq_A2780_Human1.25631657
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21620663
64* HNF4A_19822575_ChIP-Seq_HepG2_Human1.20991238
65* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20934248
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.18939815
67CJUN_26792858_Chip-Seq_BT549_Human1.17442035
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17378756
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17256283
70* GATA4_25053715_ChIP-Seq_YYC3_Human1.15926068
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15374710
72* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15107294
73* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15077620
74* GATA6_25053715_ChIP-Seq_YYC3_Human1.12746158
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12653778
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11187652
77FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.10269718
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10049711
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08588527
80AR_21909140_ChIP-Seq_LNCAP_Human1.06591568
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05838166
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05182979
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03574480
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.02133196
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01813950
86* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01796917
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.00739190
88GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00403285
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00112448
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00088343
91CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99928942
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99056510
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98238676
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98220144
95* RACK7_27058665_Chip-Seq_MCF-7_Human0.97561100
96* TCF4_23295773_ChIP-Seq_U87_Human0.94974576
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94000700
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93589717
99TP53_16413492_ChIP-PET_HCT116_Human0.93040038
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92967928
101* TP63_23658742_ChIP-Seq_EP156T_Human0.92618594
102GATA2_21666600_ChIP-Seq_HMVEC_Human0.92223594
103* GATA3_24758297_ChIP-Seq_MCF-7_Human0.91614067
104* ISL1_27105846_Chip-Seq_CPCs_Mouse0.89049173
105* TBL1_22424771_ChIP-Seq_293T_Human0.88916459
106RUNX1_27514584_Chip-Seq_MCF-7_Human0.88492375
107HTT_18923047_ChIP-ChIP_STHdh_Human0.88484287
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88387340
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88251685
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88045144
111HNFA_21074721_ChIP-Seq_CACO-2_Human0.87995340
112SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87806038
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86713778
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86622284
115EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.81910917
116AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81627713
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80347047
118* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80202711
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80118690
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80007639
121* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79103557
122BCAT_22108803_ChIP-Seq_LS180_Human0.78432364
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77333801
124EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.77091084
125* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76898574
126* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76898574
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75818748
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75274670
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.73135222
130NANOG_18692474_ChIP-Seq_MEFs_Mouse0.72848753
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72562590
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72393136
133* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.72330134
134TCF3_18692474_ChIP-Seq_MESCs_Mouse0.72230644
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71852298
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71852298
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.71437096
138OCT4_18692474_ChIP-Seq_MEFs_Mouse0.70004508
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.69431985
140* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.69235217
141* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.68377850
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.68286803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.99051874
2MP0004084_abnormal_cardiac_muscle4.72923242
3MP0004215_abnormal_myocardial_fiber3.59371388
4MP0002139_abnormal_hepatobiliary_system3.41995606
5MP0005330_cardiomyopathy3.35779151
6MP0005360_urolithiasis3.32924079
7MP0005085_abnormal_gallbladder_physiolo3.31057506
8MP0003646_muscle_fatigue3.25493434
9MP0004036_abnormal_muscle_relaxation3.04518953
10MP0000751_myopathy2.82677641
11MP0003806_abnormal_nucleotide_metabolis2.82217571
12MP0005365_abnormal_bile_salt2.80434575
13MP0008775_abnormal_heart_ventricle2.62223221
14MP0002972_abnormal_cardiac_muscle2.58079284
15MP0000749_muscle_degeneration2.43939392
16MP0004087_abnormal_muscle_fiber2.36330541
17MP0005385_cardiovascular_system_phenoty2.26688019
18MP0001544_abnormal_cardiovascular_syste2.26688019
19MP0004130_abnormal_muscle_cell2.26181097
20MP0006138_congestive_heart_failure2.23902603
21* MP0010630_abnormal_cardiac_muscle2.20396347
22MP0003137_abnormal_impulse_conducting2.15716254
23MP0005620_abnormal_muscle_contractility2.06854602
24MP0008875_abnormal_xenobiotic_pharmacok2.04191560
25MP0003705_abnormal_hypodermis_morpholog1.98597940
26MP0003221_abnormal_cardiomyocyte_apopto1.97072429
27MP0005670_abnormal_white_adipose1.96736461
28MP0000750_abnormal_muscle_regeneration1.94682167
29MP0004484_altered_response_of1.93186906
30MP0002269_muscular_atrophy1.87841398
31MP0003252_abnormal_bile_duct1.86514318
32MP0010329_abnormal_lipoprotein_level1.75549852
33MP0003828_pulmonary_edema1.72957490
34MP0005666_abnormal_adipose_tissue1.72321096
35MP0006036_abnormal_mitochondrial_physio1.68672186
36MP0004085_abnormal_heartbeat1.64839815
37MP0005332_abnormal_amino_acid1.62909399
38MP0000537_abnormal_urethra_morphology1.59129357
39MP0001661_extended_life_span1.59076954
40MP0002127_abnormal_cardiovascular_syste1.52650404
41MP0003567_abnormal_fetal_cardiomyocyte1.51456684
42MP0003950_abnormal_plasma_membrane1.50528475
43MP0002106_abnormal_muscle_physiology1.47964144
44MP0003566_abnormal_cell_adhesion1.46645810
45MP0005083_abnormal_biliary_tract1.45582602
46MP0009840_abnormal_foam_cell1.44590161
47MP0004185_abnormal_adipocyte_glucose1.38453287
48MP0010368_abnormal_lymphatic_system1.35175119
49MP0000579_abnormal_nail_morphology1.31804366
50MP0005319_abnormal_enzyme/_coenzyme1.30553674
51MP0001666_abnormal_nutrient_absorption1.27184319
52MP0004510_myositis1.25319676
53MP0000462_abnormal_digestive_system1.21465763
54MP0008004_abnormal_stomach_pH1.19697624
55MP0004272_abnormal_basement_membrane1.17658446
56MP0005451_abnormal_body_composition1.17586839
57MP0000747_muscle_weakness1.16912800
58MP0004233_abnormal_muscle_weight1.16461494
59MP0002118_abnormal_lipid_homeostasis1.15035060
60MP0005369_muscle_phenotype1.12495107
61MP0005375_adipose_tissue_phenotype1.09519461
62MP0000759_abnormal_skeletal_muscle1.08701896
63MP0009780_abnormal_chondrocyte_physiolo1.07968827
64MP0002332_abnormal_exercise_endurance1.07951828
65MP0005165_increased_susceptibility_to1.07820828
66MP0006035_abnormal_mitochondrial_morpho1.06474457
67MP0002102_abnormal_ear_morphology1.05936222
68MP0000609_abnormal_liver_physiology1.05285863
69MP0003195_calcinosis1.04196781
70* MP0000266_abnormal_heart_morphology1.03115240
71MP0010234_abnormal_vibrissa_follicle1.02695001
72MP0000467_abnormal_esophagus_morphology1.00912520
73MP0005266_abnormal_metabolism1.00013799
74MP0003186_abnormal_redox_activity0.99611036
75MP0010678_abnormal_skin_adnexa0.99514712
76MP0004145_abnormal_muscle_electrophysio0.94667653
77MP0000762_abnormal_tongue_morphology0.93307304
78MP0003937_abnormal_limbs/digits/tail_de0.91208018
79MP0003191_abnormal_cellular_cholesterol0.91144256
80MP0002234_abnormal_pharynx_morphology0.90773841
81MP0003283_abnormal_digestive_organ0.88728283
82MP0009643_abnormal_urine_homeostasis0.87316925
83MP0003119_abnormal_digestive_system0.86490055
84MP0003984_embryonic_growth_retardation0.83692299
85MP0002088_abnormal_embryonic_growth/wei0.83683095
86MP0000566_synostosis0.82147950
87MP0004019_abnormal_vitamin_homeostasis0.80789958
88MP0000383_abnormal_hair_follicle0.80120467
89MP0009384_cardiac_valve_regurgitation0.77065843
90MP0002971_abnormal_brown_adipose0.75760537
91MP0002098_abnormal_vibrissa_morphology0.74432586
92* MP0002128_abnormal_blood_circulation0.73516106
93MP0005187_abnormal_penis_morphology0.70232782
94MP0000343_altered_response_to0.70221866
95MP0000230_abnormal_systemic_arterial0.69927527
96MP0001672_abnormal_embryogenesis/_devel0.69346921
97MP0005380_embryogenesis_phenotype0.69346921
98MP0005584_abnormal_enzyme/coenzyme_acti0.68888731
99MP0002078_abnormal_glucose_homeostasis0.67861957
100MP0004043_abnormal_pH_regulation0.67587238
101MP0005409_darkened_coat_color0.67016162
102MP0004147_increased_porphyrin_level0.65429766
103MP0000003_abnormal_adipose_tissue0.64582566
104MP0010352_gastrointestinal_tract_polyps0.64577047
105MP0003279_aneurysm0.64319063
106MP0008438_abnormal_cutaneous_collagen0.62831835
107MP0003941_abnormal_skin_development0.62068186
108MP0004264_abnormal_extraembryonic_tissu0.61238183
109MP0002138_abnormal_hepatobiliary_system0.60256054
110MP0000598_abnormal_liver_morphology0.60253729
111MP0002254_reproductive_system_inflammat0.57771300
112MP0003123_paternal_imprinting0.56019321
113MP0009697_abnormal_copulation0.56016414
114MP0009053_abnormal_anal_canal0.55928627
115MP0002876_abnormal_thyroid_physiology0.55345734
116MP0005376_homeostasis/metabolism_phenot0.55328129
117MP0002086_abnormal_extraembryonic_tissu0.55102135
118MP0000013_abnormal_adipose_tissue0.54847179
119MP0002925_abnormal_cardiovascular_devel0.53474333
120MP0001764_abnormal_homeostasis0.53111711
121MP0003890_abnormal_embryonic-extraembry0.53068336
122MP0005275_abnormal_skin_tensile0.53009207
123MP0002697_abnormal_eye_size0.51169647
124MP0003868_abnormal_feces_composition0.47489924
125MP0001697_abnormal_embryo_size0.43373101
126MP0001765_abnormal_ion_homeostasis0.42213246
127MP0002108_abnormal_muscle_morphology0.40865742
128MP0000516_abnormal_urinary_system0.40679620
129MP0005367_renal/urinary_system_phenotyp0.40679620
130MP0001730_embryonic_growth_arrest0.39799559

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.48651172
2Ventricular tachycardia (HP:0004756)5.81482533
3* Right ventricular cardiomyopathy (HP:0011663)5.06086662
4Atrial fibrillation (HP:0005110)4.74435091
5Primary atrial arrhythmia (HP:0001692)4.43083380
6Hypoglycemic coma (HP:0001325)4.39621093
7Lipoatrophy (HP:0100578)4.34996014
8Supraventricular tachycardia (HP:0004755)4.25963308
9Supraventricular arrhythmia (HP:0005115)4.20245761
10Myoglobinuria (HP:0002913)4.01076461
11* Syncope (HP:0001279)3.99732773
12Calf muscle hypertrophy (HP:0008981)3.89251502
13Exercise-induced muscle cramps (HP:0003710)3.87189040
14Muscle fiber splitting (HP:0003555)3.79780369
15* Palpitations (HP:0001962)3.64923342
16Hyporeflexia of lower limbs (HP:0002600)3.64678264
17Dilated cardiomyopathy (HP:0001644)3.61355078
18Hyperammonemia (HP:0001987)3.58337249
19Hyperglycinuria (HP:0003108)3.50263328
20Abnormality of the calf musculature (HP:0001430)3.50113011
21* Ventricular arrhythmia (HP:0004308)3.44713422
22Abnormality of the left ventricular outflow tract (HP:0011103)3.44389731
23Subaortic stenosis (HP:0001682)3.44389731
24Ketoacidosis (HP:0001993)3.44071192
25Ketosis (HP:0001946)3.38991844
26Bundle branch block (HP:0011710)3.38774940
27Abnormality of fatty-acid metabolism (HP:0004359)3.36315439
28Muscle hypertrophy of the lower extremities (HP:0008968)3.32771205
29Intrahepatic cholestasis (HP:0001406)3.32228262
30Rhabdomyolysis (HP:0003201)3.30078371
31Dicarboxylic aciduria (HP:0003215)3.27874525
32Abnormality of dicarboxylic acid metabolism (HP:0010995)3.27874525
33Atrioventricular block (HP:0001678)3.18651144
34Abnormality of glycine metabolism (HP:0010895)3.17202192
35Abnormality of serine family amino acid metabolism (HP:0010894)3.17202192
36Cerebral edema (HP:0002181)3.16329421
37Exercise-induced myalgia (HP:0003738)3.13926484
38Asymmetric septal hypertrophy (HP:0001670)3.10942787
39Hyperglycinemia (HP:0002154)3.07883078
40Prolonged QT interval (HP:0001657)3.04898072
41Heart block (HP:0012722)3.04293712
42Xanthomatosis (HP:0000991)3.03184032
43Increased connective tissue (HP:0009025)3.01158367
44Deep venous thrombosis (HP:0002625)2.97708474
45Hypoalphalipoproteinemia (HP:0003233)2.97463346
46Abnormal atrioventricular conduction (HP:0005150)2.92278711
47Ventricular fibrillation (HP:0001663)2.84248383
48Ragged-red muscle fibers (HP:0003200)2.83310298
49Hepatic necrosis (HP:0002605)2.81827047
50EMG: myopathic abnormalities (HP:0003458)2.77256998
51Abnormality of monocarboxylic acid metabolism (HP:0010996)2.76660412
52Hypolipoproteinemia (HP:0010981)2.73079592
53Hypoplastic left heart (HP:0004383)2.68251770
54Patent foramen ovale (HP:0001655)2.64332219
55Hypobetalipoproteinemia (HP:0003563)2.60749088
56Hyperinsulinemic hypoglycemia (HP:0000825)2.59571148
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.54993329
58Lethargy (HP:0001254)2.54007829
59Acute encephalopathy (HP:0006846)2.52858852
60Testicular atrophy (HP:0000029)2.51532298
61Abnormality of serum amino acid levels (HP:0003112)2.47991720
62Abnormality of aromatic amino acid family metabolism (HP:0004338)2.47270548
63Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.46463781
64Metabolic acidosis (HP:0001942)2.45104563
65Hyperlipoproteinemia (HP:0010980)2.44954287
66Nausea (HP:0002018)2.42699019
67Skin nodule (HP:0200036)2.41835762
68Hyperglycemia (HP:0003074)2.41333253
69Abnormal mitochondria in muscle tissue (HP:0008316)2.40616016
70Centrally nucleated skeletal muscle fibers (HP:0003687)2.40410832
71Acute necrotizing encephalopathy (HP:0006965)2.36274571
72Increased serum pyruvate (HP:0003542)2.35930574
73Abnormality of glycolysis (HP:0004366)2.35930574
74Proximal tubulopathy (HP:0000114)2.34433080
75Late onset (HP:0003584)2.31170726
76Generalized aminoaciduria (HP:0002909)2.30859355
77Palmoplantar keratoderma (HP:0000982)2.29904783
78Hyperactive renin-angiotensin system (HP:0000841)2.29076794
79Neck muscle weakness (HP:0000467)2.27105325
80Abnormality of alanine metabolism (HP:0010916)2.25733768
81Hyperalaninemia (HP:0003348)2.25733768
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25733768
83Double outlet right ventricle (HP:0001719)2.24523693
84Congenital malformation of the right heart (HP:0011723)2.24523693
85Distal lower limb muscle weakness (HP:0009053)2.22957136
86Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22464437
87EMG: neuropathic changes (HP:0003445)2.21338246
88Difficulty climbing stairs (HP:0003551)2.21156042
89Bradycardia (HP:0001662)2.20027501
90Skin pits (HP:0100276)2.19396942
91Epidermoid cyst (HP:0200040)2.16950373
92Decreased circulating renin level (HP:0003351)2.15794836
93Abnormal EKG (HP:0003115)2.11142824
94Periauricular skin pits (HP:0100277)2.09398322
95Preauricular pit (HP:0004467)2.09398322
96Multiple enchondromatosis (HP:0005701)2.05483773
97Conjunctival hamartoma (HP:0100780)2.03745681
98Hepatocellular necrosis (HP:0001404)2.03056668
99Abnormality of glutamine family amino acid metabolism (HP:0010902)2.01821581
100Lactic acidosis (HP:0003128)2.00339772
101Abnormal ventriculo-arterial connection (HP:0011563)1.99945487
102Transposition of the great arteries (HP:0001669)1.99945487
103Abnormal connection of the cardiac segments (HP:0011545)1.99945487
104Difficulty running (HP:0009046)1.99411837
105Vomiting (HP:0002013)1.98694501
106Abnormality of methionine metabolism (HP:0010901)1.98325198
107Hypoglycemic seizures (HP:0002173)1.98054837
108Abnormal tarsal ossification (HP:0008369)1.97222999
109Abnormality of sulfur amino acid metabolism (HP:0004339)1.94577675
110Left ventricular hypertrophy (HP:0001712)1.94390874
111Neonatal death (HP:0003811)1.94261064
112Prolonged partial thromboplastin time (HP:0003645)1.93620578
113Vascular calcification (HP:0004934)1.93326670
114Hypoplastic heart (HP:0001961)1.93259545
115Increased muscle lipid content (HP:0009058)1.92652345
116Progressive macrocephaly (HP:0004481)1.90360190
117Hip contracture (HP:0003273)1.90356549
118Rimmed vacuoles (HP:0003805)1.89981258
119Esophageal varix (HP:0002040)1.89542166
120Increased CSF lactate (HP:0002490)1.89169715
121Abnormal pancreas size (HP:0012094)1.85766048
122Abnormality of urine glucose concentration (HP:0011016)1.85541946
123Glycosuria (HP:0003076)1.85541946
124* Sudden cardiac death (HP:0001645)1.78457838
125Abnormality of the tricuspid valve (HP:0001702)1.75150715
126Mildly elevated creatine phosphokinase (HP:0008180)1.73302974
127Areflexia of lower limbs (HP:0002522)1.70991570
128Congestive heart failure (HP:0001635)1.69301118
129Abnormality of renin-angiotensin system (HP:0000847)1.66990509
130Limited hip movement (HP:0008800)1.63532774
131Abnormality of the salivary glands (HP:0010286)1.61744129
132Renal cortical cysts (HP:0000803)1.61393658
133Cardiovascular calcification (HP:0011915)1.61166449
134Abnormal biliary tract morphology (HP:0012440)1.61102170
135Truncus arteriosus (HP:0001660)1.57965297
136Flat acetabular roof (HP:0003180)1.56808248
137Toxemia of pregnancy (HP:0100603)1.56720887
138Lymphangioma (HP:0100764)1.55989226
139Ridged nail (HP:0001807)1.50760202
140Prenatal maternal abnormality (HP:0002686)1.49805354
141Absent eyebrow (HP:0002223)1.45501497
142Coarctation of aorta (HP:0001680)1.45273467
143Generalized muscle weakness (HP:0003324)1.45061890
144Vertebral clefting (HP:0008428)1.41097031
145Conjugated hyperbilirubinemia (HP:0002908)1.40392112
146Maternal diabetes (HP:0009800)1.39910039
147Central scotoma (HP:0000603)1.39696706
148Abnormality of chloride homeostasis (HP:0011422)1.38447290
149Plantar hyperkeratosis (HP:0007556)1.36196563
150Abnormality of vitamin metabolism (HP:0100508)1.33577780

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.96294101
2BCKDK3.81294620
3PKN23.69410715
4OBSCN3.34575312
5LMTK23.27733588
6MYLK3.22911850
7PDK33.08946988
8PDK43.08946988
9STK38L2.72512209
10TRIB32.64237832
11EPHA22.51100121
12NEK12.45233621
13PIK3CA2.16285704
14DMPK2.11169270
15STK392.04809524
16MST42.01328035
17STK241.95035531
18PDK21.84852085
19LATS11.82878069
20PHKG21.69844865
21PHKG11.69844865
22ZAK1.62833111
23PAK31.55771182
24ACVR1B1.55594331
25MAP3K31.52276917
26TIE11.51237756
27FLT31.45578963
28INSRR1.37978992
29PLK41.31875725
30MAP3K121.30129506
31RIPK11.29733447
32SIK11.25477699
33FER1.07403110
34CAMK2D1.07174131
35LATS21.04053681
36TNIK1.02818841
37CDC42BPA1.02736790
38CDK120.95777292
39PDGFRA0.95733043
40ILK0.95456516
41PRKAA20.95339614
42NEK90.94137359
43RPS6KB20.93901355
44PINK10.93565354
45MAP3K50.93146063
46MAP3K70.92846846
47MAP2K30.91653049
48LIMK10.90807496
49MET0.89820828
50STK40.89551302
51PTK60.88971851
52TTK0.88739196
53WNK40.87287248
54MAPKAPK30.86825745
55STK380.86037679
56PRKD10.84357377
57FGFR40.79321938
58FRK0.78791424
59GRK70.77676497
60EPHB20.77425849
61ROCK10.77345166
62NME20.76846775
63MST1R0.74960163
64PTK2B0.74819668
65DAPK30.73136147
66ERBB40.71204018
67OXSR10.71049023
68NLK0.69650940
69PRKAA10.69636687
70PTK20.68451847
71MTOR0.68319073
72KDR0.68259982
73ERN10.68223114
74TRPM70.66710020
75MAP2K10.64114829
76AKT20.63776263
77CAMK10.60447093
78AKT30.54875852
79PBK0.54492311
80STK30.54443608
81CAMK1D0.54182293
82EIF2AK30.53524637
83MAP3K110.50683790
84EPHA30.48944184
85BRSK20.47837616
86MUSK0.47528591
87CAMK2G0.47330676
88KSR20.46700632
89NUAK10.46080486
90CDK40.46021507
91BMPR1B0.45692679
92GRK10.45570145
93PRKG20.44753825
94MAP3K80.44465922
95CAMK2A0.44119822
96PRKACG0.42345096
97CAMK40.41930377
98ROCK20.40947729
99ABL20.40646056
100MAP2K40.39322390
101FGFR10.38348394
102MAPK110.37777963
103RET0.37310997
104PAK20.37092945
105PRKACB0.36673155
106MAP2K20.36099937
107MAP3K100.35466436
108MAPK120.33184797
109PDPK10.31830110
110AURKB0.31186081
111MAP4K20.30686675
112CAMK2B0.30570544
113TGFBR10.28902553
114PIK3CG0.28020129
115MAP3K90.27960212
116ERBB30.27738671
117CSNK1E0.27667581
118STK100.27219528
119LRRK20.26946598
120TGFBR20.25678986
121PAK40.25604132
122MAP3K60.25299177
123PRKD30.25271184
124WNK10.24652061
125ERBB20.24621107
126PRKACA0.24533330
127PRKCE0.23843288
128PRKCI0.23064554
129BCR0.18565324
130EPHB10.16685980
131ADRBK10.16248132
132RPS6KC10.15757624

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.12924181
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.62999380
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.62842194
4Fatty acid degradation_Homo sapiens_hsa000713.27281438
5Propanoate metabolism_Homo sapiens_hsa006403.21291780
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.93414972
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.76082989
8Carbon metabolism_Homo sapiens_hsa012002.44068455
9Fatty acid metabolism_Homo sapiens_hsa012122.38583994
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.35964206
11Arginine biosynthesis_Homo sapiens_hsa002202.28893156
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14514832
13Tryptophan metabolism_Homo sapiens_hsa003802.13612990
14Cardiac muscle contraction_Homo sapiens_hsa042602.07819486
15Pyruvate metabolism_Homo sapiens_hsa006202.03966703
16Nitrogen metabolism_Homo sapiens_hsa009102.00518989
17PPAR signaling pathway_Homo sapiens_hsa033202.00084653
18Butanoate metabolism_Homo sapiens_hsa006501.92315848
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.80595313
20Dilated cardiomyopathy_Homo sapiens_hsa054141.76976051
21Peroxisome_Homo sapiens_hsa041461.64069845
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62555042
23Biosynthesis of amino acids_Homo sapiens_hsa012301.62213353
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52862437
25beta-Alanine metabolism_Homo sapiens_hsa004101.50930225
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.49925992
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46060093
28Starch and sucrose metabolism_Homo sapiens_hsa005001.44996813
29Parkinsons disease_Homo sapiens_hsa050121.43326470
30Oxidative phosphorylation_Homo sapiens_hsa001901.43312574
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40729480
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34312255
33Phenylalanine metabolism_Homo sapiens_hsa003601.32784837
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30274645
35Complement and coagulation cascades_Homo sapiens_hsa046101.29854596
36Fat digestion and absorption_Homo sapiens_hsa049751.26054289
37Mineral absorption_Homo sapiens_hsa049781.22542179
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21600895
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19475282
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18718159
41* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17561713
42Chemical carcinogenesis_Homo sapiens_hsa052041.16668925
43Selenocompound metabolism_Homo sapiens_hsa004501.14902730
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14594618
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.12654173
46Fatty acid elongation_Homo sapiens_hsa000621.08726607
47Tyrosine metabolism_Homo sapiens_hsa003501.04476378
48Linoleic acid metabolism_Homo sapiens_hsa005911.04080561
49Lysine degradation_Homo sapiens_hsa003101.03092885
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00816030
51Alzheimers disease_Homo sapiens_hsa050101.00765780
52Bile secretion_Homo sapiens_hsa049760.98629867
53Sulfur metabolism_Homo sapiens_hsa009200.96278135
54Caffeine metabolism_Homo sapiens_hsa002320.94087092
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93233068
56Huntingtons disease_Homo sapiens_hsa050160.92750548
57Fatty acid biosynthesis_Homo sapiens_hsa000610.92198270
58Arginine and proline metabolism_Homo sapiens_hsa003300.92092602
59Pancreatic secretion_Homo sapiens_hsa049720.87613802
60Ovarian steroidogenesis_Homo sapiens_hsa049130.80441085
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78547442
62Protein digestion and absorption_Homo sapiens_hsa049740.78431802
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.78396994
64Retinol metabolism_Homo sapiens_hsa008300.78157559
65Galactose metabolism_Homo sapiens_hsa000520.77204187
66Histidine metabolism_Homo sapiens_hsa003400.76593613
67Glycerolipid metabolism_Homo sapiens_hsa005610.75838052
68Glutathione metabolism_Homo sapiens_hsa004800.75067649
69Fructose and mannose metabolism_Homo sapiens_hsa000510.73833764
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73681393
71Glucagon signaling pathway_Homo sapiens_hsa049220.70763111
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.69563634
73Insulin resistance_Homo sapiens_hsa049310.68840439
74Circadian rhythm_Homo sapiens_hsa047100.67938565
75Renin secretion_Homo sapiens_hsa049240.65762921
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.62520013
77TGF-beta signaling pathway_Homo sapiens_hsa043500.61144870
78Folate biosynthesis_Homo sapiens_hsa007900.60996795
79Arachidonic acid metabolism_Homo sapiens_hsa005900.57815914
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55217803
81Hippo signaling pathway_Homo sapiens_hsa043900.52547384
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51979896
83ABC transporters_Homo sapiens_hsa020100.51866870
84Adherens junction_Homo sapiens_hsa045200.51645795
85AMPK signaling pathway_Homo sapiens_hsa041520.51012418
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50357590
87One carbon pool by folate_Homo sapiens_hsa006700.49498907
88Steroid biosynthesis_Homo sapiens_hsa001000.49406019
89Renin-angiotensin system_Homo sapiens_hsa046140.49198322
90Pentose phosphate pathway_Homo sapiens_hsa000300.49098675
91Metabolic pathways_Homo sapiens_hsa011000.48114670
92Tight junction_Homo sapiens_hsa045300.46871211
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44470031
94Insulin secretion_Homo sapiens_hsa049110.44203504
95Sulfur relay system_Homo sapiens_hsa041220.44049029
96Insulin signaling pathway_Homo sapiens_hsa049100.43217286
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.42718176
98Viral myocarditis_Homo sapiens_hsa054160.42309015
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.41630663
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41270197
101Vitamin digestion and absorption_Homo sapiens_hsa049770.37389063
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37249838
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.36098417
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34992885
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32508156
106Thyroid hormone synthesis_Homo sapiens_hsa049180.31538595
107Ether lipid metabolism_Homo sapiens_hsa005650.31176902
108HIF-1 signaling pathway_Homo sapiens_hsa040660.30221183
109Focal adhesion_Homo sapiens_hsa045100.28343571
110Calcium signaling pathway_Homo sapiens_hsa040200.27968280
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27434417
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.24643847
113Staphylococcus aureus infection_Homo sapiens_hsa051500.23658525
114ECM-receptor interaction_Homo sapiens_hsa045120.22042525
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.21254820
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20370710
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17408463
118Vitamin B6 metabolism_Homo sapiens_hsa007500.16076672
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11321273
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11193464
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07884783
122Amoebiasis_Homo sapiens_hsa051460.06379817
123Type II diabetes mellitus_Homo sapiens_hsa049300.06135146
124Bladder cancer_Homo sapiens_hsa052190.03715838
125Proteoglycans in cancer_Homo sapiens_hsa052050.03167114

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