PKN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.96446838
2regulation of gamma-delta T cell differentiation (GO:0045586)4.97173773
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.88364597
4negative regulation of cell killing (GO:0031342)4.88364597
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.88221361
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.88221361
7antigen processing and presentation of endogenous antigen (GO:0019883)4.80478438
8regulation of gamma-delta T cell activation (GO:0046643)4.75638069
9positive thymic T cell selection (GO:0045059)4.62795982
10regulation of interferon-beta biosynthetic process (GO:0045357)4.42033376
11regulation of B cell receptor signaling pathway (GO:0050855)4.35628279
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.30648044
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.12392834
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.12392834
15modulation by symbiont of host immune response (GO:0052553)4.12392834
16positive regulation by symbiont of host defense response (GO:0052509)4.12392834
17modulation by symbiont of host defense response (GO:0052031)4.12392834
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.12392834
19B cell receptor signaling pathway (GO:0050853)4.06251863
20positive regulation of B cell differentiation (GO:0045579)4.01308101
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.85629479
22regulation of interleukin-12 biosynthetic process (GO:0045075)3.79346551
23positive T cell selection (GO:0043368)3.69778160
24regulation of B cell differentiation (GO:0045577)3.68276227
25negative T cell selection (GO:0043383)3.64381153
26negative thymic T cell selection (GO:0045060)3.63727047
27leukocyte aggregation (GO:0070486)3.63176433
28tolerance induction (GO:0002507)3.62787491
29thymic T cell selection (GO:0045061)3.54817998
30protein localization to endosome (GO:0036010)3.51119059
31positive regulation of histone deacetylation (GO:0031065)3.48313219
32response to peptidoglycan (GO:0032494)3.47108648
33cellular extravasation (GO:0045123)3.43727010
34T cell migration (GO:0072678)3.40456908
35T cell selection (GO:0045058)3.35966685
36macrophage activation involved in immune response (GO:0002281)3.35356259
37modulation by virus of host process (GO:0019054)3.31717940
38neutrophil activation involved in immune response (GO:0002283)3.30920903
39modulation by symbiont of host cellular process (GO:0044068)3.29956276
40response to muramyl dipeptide (GO:0032495)3.29470112
41mannose metabolic process (GO:0006013)3.28431116
42response to interleukin-15 (GO:0070672)3.28272259
43negative regulation of granulocyte differentiation (GO:0030853)3.28094461
443-UTR-mediated mRNA stabilization (GO:0070935)3.26984411
45positive regulation of antigen processing and presentation (GO:0002579)3.16162217
46neutrophil activation (GO:0042119)3.14864507
47apoptotic process involved in morphogenesis (GO:0060561)3.14459169
48activated T cell proliferation (GO:0050798)3.13749140
49positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.09956760
50response to laminar fluid shear stress (GO:0034616)3.08513601
51barbed-end actin filament capping (GO:0051016)3.06089155
52negative regulation of cell size (GO:0045792)3.02939065
53NIK/NF-kappaB signaling (GO:0038061)3.02434989
54positive regulation of interferon-alpha production (GO:0032727)3.01622801
55JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.01475389
56regulation of leukocyte degranulation (GO:0043300)2.98453340
57negative regulation of phagocytosis (GO:0050765)2.97245036
58antigen receptor-mediated signaling pathway (GO:0050851)2.95619952
59regulation of extracellular matrix disassembly (GO:0010715)2.94013636
60granulocyte activation (GO:0036230)2.92174081
61negative regulation of interleukin-12 production (GO:0032695)2.91931833
62stress fiber assembly (GO:0043149)2.91849029
63immunoglobulin mediated immune response (GO:0016064)2.88902065
64leukocyte cell-cell adhesion (GO:0007159)2.88391006
65I-kappaB phosphorylation (GO:0007252)2.87860543
66respiratory burst (GO:0045730)2.85812008
67regulation of interferon-alpha production (GO:0032647)2.85428709
68regulation of myeloid leukocyte mediated immunity (GO:0002886)2.82184526
69antigen processing and presentation via MHC class Ib (GO:0002475)2.82052988
70germinal center formation (GO:0002467)2.81981001
71regulation of early endosome to late endosome transport (GO:2000641)2.81014358
72regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.80610978
73regulation of type I interferon-mediated signaling pathway (GO:0060338)2.80174437
74mature B cell differentiation (GO:0002335)2.80093641
75B cell homeostasis (GO:0001782)2.79853345
76myeloid cell activation involved in immune response (GO:0002275)2.79628514
77cortical actin cytoskeleton organization (GO:0030866)2.79352462
78pentose-phosphate shunt (GO:0006098)2.77699033
79regulation of defense response to virus by virus (GO:0050690)2.77639997
80negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.77521806
81regulation of mast cell degranulation (GO:0043304)2.77158100
82regulation of T cell tolerance induction (GO:0002664)2.76634424
83negative regulation of B cell proliferation (GO:0030889)2.76434185
84detection of bacterium (GO:0016045)2.75637583
85positive regulation of interleukin-2 production (GO:0032743)2.75620786
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.75346488
87detection of other organism (GO:0098543)2.75024260
88regulation of mammary gland epithelial cell proliferation (GO:0033599)2.74402974
89pinocytosis (GO:0006907)2.72476112
90positive regulation of Rap GTPase activity (GO:0032854)2.71878161
91cellular response to zinc ion (GO:0071294)2.71014762
92negative regulation of bone resorption (GO:0045779)2.70103968
93response to type I interferon (GO:0034340)2.69360737
94natural killer cell differentiation (GO:0001779)2.69194287
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.68975472
96T cell costimulation (GO:0031295)2.68328516
97T cell receptor signaling pathway (GO:0050852)2.66825193
98COPI coating of Golgi vesicle (GO:0048205)2.66197438
99Golgi transport vesicle coating (GO:0048200)2.66197438
100response to host immune response (GO:0052572)2.66129437
101response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66129437
102negative regulation of erythrocyte differentiation (GO:0045647)2.64531372
103regulation of antigen processing and presentation (GO:0002577)2.64115545
104lymphocyte costimulation (GO:0031294)2.61717147
105cellular response to virus (GO:0098586)2.60819048
106negative regulation of necroptotic process (GO:0060546)2.59970966
107cellular response to interleukin-15 (GO:0071350)2.59750660
108activation of Rac GTPase activity (GO:0032863)2.58438708
109regulation of interleukin-2 biosynthetic process (GO:0045076)2.57931109
110lipopolysaccharide-mediated signaling pathway (GO:0031663)2.57796089
111type I interferon signaling pathway (GO:0060337)2.57768441
112cellular response to type I interferon (GO:0071357)2.57768441
113lymphocyte homeostasis (GO:0002260)2.56753321
114regulation of dendritic cell antigen processing and presentation (GO:0002604)2.56093444
115negative regulation of interleukin-6 production (GO:0032715)2.55446234
116interferon-gamma-mediated signaling pathway (GO:0060333)2.55437602
117response to host (GO:0075136)2.54781452
118response to host defenses (GO:0052200)2.54781452
119response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.54781452
120intracellular estrogen receptor signaling pathway (GO:0030520)2.54452779
121T cell proliferation (GO:0042098)2.54185076
122embryonic process involved in female pregnancy (GO:0060136)2.52583249
123positive regulation of Cdc42 GTPase activity (GO:0043089)2.51747168
124positive regulation of blood vessel endothelial cell migration (GO:0043536)2.51439556
125regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.51201188
126regulation of necroptotic process (GO:0060544)2.51151253
127regulation of glucose import in response to insulin stimulus (GO:2001273)2.49862647
128angiogenesis involved in wound healing (GO:0060055)2.49224365
129immune response-activating cell surface receptor signaling pathway (GO:0002429)2.48591691
130interferon-gamma production (GO:0032609)2.48029029
131megakaryocyte development (GO:0035855)2.47914274
132T cell homeostasis (GO:0043029)2.47253021
133positive regulation of protein deacetylation (GO:0090312)2.47047709
134regulation of alpha-beta T cell proliferation (GO:0046640)2.45846529
135negative regulation of skeletal muscle tissue development (GO:0048642)2.44956876
136negative regulation of viral release from host cell (GO:1902187)2.44645396
137adaptation of signaling pathway (GO:0023058)2.44560338
138adherens junction assembly (GO:0034333)2.42819097
139focal adhesion assembly (GO:0048041)2.41962625
140cell-substrate adherens junction assembly (GO:0007045)2.41962625
141maternal placenta development (GO:0001893)2.40394903
142glucose catabolic process (GO:0006007)2.38738285
143modulation by virus of host morphology or physiology (GO:0019048)2.37895703
144regulation of mast cell activation involved in immune response (GO:0033006)2.37683347
145regulation of histone H3-K27 methylation (GO:0061085)2.34908356
146Peyers patch development (GO:0048541)2.34740168
147mucosal-associated lymphoid tissue development (GO:0048537)2.34740168
148signal complex assembly (GO:0007172)2.34423987
149regulation of superoxide anion generation (GO:0032928)2.34035934
150regulation of ARF GTPase activity (GO:0032312)2.32504032
151regulation of regulated secretory pathway (GO:1903305)2.32150954
152activation of MAPKKK activity (GO:0000185)2.31699360
153positive regulation of protein dephosphorylation (GO:0035307)2.29557819
154positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.27532618
155positive regulation of receptor recycling (GO:0001921)2.27289304
156positive regulation of myotube differentiation (GO:0010831)2.25997027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.36939774
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.35460789
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.19172251
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.58978976
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22222193
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.17652917
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.17104181
8* VDR_21846776_ChIP-Seq_THP-1_Human3.02352539
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.99945190
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91362724
11MYC_22102868_ChIP-Seq_BL_Human2.86003377
12RUNX_20019798_ChIP-Seq_JUKART_Human2.82232803
13SCL_19346495_ChIP-Seq_HPC-7_Human2.81778211
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79728423
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.79248099
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.64811822
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.62196343
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58998141
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.55808886
20MAF_26560356_Chip-Seq_TH1_Human2.39750384
21VDR_24763502_ChIP-Seq_THP-1_Human2.35315285
22* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.33554912
23TCF7_22412390_ChIP-Seq_EML_Mouse2.31403029
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.29275079
25KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24615831
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.23447554
27* SPI1_23127762_ChIP-Seq_K562_Human2.21123592
28MYB_26560356_Chip-Seq_TH2_Human2.18987490
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.17292842
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.15966998
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15426625
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13746763
33KDM2B_26808549_Chip-Seq_DND41_Human2.11367241
34UTX_26944678_Chip-Seq_JUKART_Human2.10910434
35* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08884448
36STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02733856
37* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.01127446
38MYB_26560356_Chip-Seq_TH1_Human1.98269122
39* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95345067
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.94664784
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.94568483
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87128827
43* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80589722
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73822016
45* ELK3_25401928_ChIP-Seq_HUVEC_Human1.72293820
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69766278
47* SPI1_23547873_ChIP-Seq_NB4_Human1.64786604
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.59349053
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55528565
50* P68_20966046_ChIP-Seq_HELA_Human1.49210922
51MAF_26560356_Chip-Seq_TH2_Human1.47740965
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47374957
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.47111363
54VDR_24787735_ChIP-Seq_THP-1_Human1.46664151
55PU_27001747_Chip-Seq_BMDM_Mouse1.46216812
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.46012429
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.44449549
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43547330
59GATA3_27048872_Chip-Seq_THYMUS_Human1.42524358
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.41775701
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.41498375
62EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38983258
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37771096
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37565021
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37416282
66GATA1_19941826_ChIP-Seq_K562_Human1.35616745
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.33701255
68LXR_22292898_ChIP-Seq_THP-1_Human1.33467291
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32581218
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32464309
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31179573
72* ELF1_20517297_ChIP-Seq_JURKAT_Human1.28739959
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27434377
74GATA2_19941826_ChIP-Seq_K562_Human1.24541453
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24469385
76ZNF263_19887448_ChIP-Seq_K562_Human1.23019548
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21701662
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21698035
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20215422
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19257926
81* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19221381
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18967674
83SMC4_20622854_ChIP-Seq_HELA_Human1.17927318
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.17462926
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15897834
86CREB1_26743006_Chip-Seq_LNCaP_Human1.15700101
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14942966
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14872177
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14176404
90BCOR_27268052_Chip-Seq_Bcells_Human1.13985311
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12337938
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11594936
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10647785
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10431429
95CLOCK_20551151_ChIP-Seq_293T_Human1.09972919
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09473095
97* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09082484
98BCL6_27268052_Chip-Seq_Bcells_Human1.08949347
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07603548
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07368392
101ATF3_27146783_Chip-Seq_COLON_Human1.06908573
102MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06800577
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06311359
104* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06107484
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05579448
106NCOR1_26117541_ChIP-Seq_K562_Human1.05048240
107* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04453215
108GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03460567
109* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02704119
110TP53_22127205_ChIP-Seq_IMR90_Human1.01564144
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01442684
112* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01389900
113DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00955417
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99958453
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99211903
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96937316
117GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94770635
118* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94186831
119RACK7_27058665_Chip-Seq_MCF-7_Human0.93585988
120* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93243525
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91873389
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91716171
123* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91185157
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87468240
125RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86976029
126PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85433896
127KDM2B_26808549_Chip-Seq_K562_Human0.84623794
128TBX20_22328084_ChIP-Seq_HEART_Mouse0.84475773
129TBX20_22080862_ChIP-Seq_HEART_Mouse0.84475773
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84063380
131CDX2_20551321_ChIP-Seq_CACO-2_Human0.83122946
132CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82153671
133GATA3_26560356_Chip-Seq_TH2_Human0.81991791
134ESR2_21235772_ChIP-Seq_MCF-7_Human0.81829950
135PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81536690
136PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80820053
137NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79772318
138IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77185202
139CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77179541
140CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77025598
141SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76578489

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.49475309
2MP0003303_peritoneal_inflammation3.30138236
3MP0005387_immune_system_phenotype3.18679360
4MP0001790_abnormal_immune_system3.18679360
5MP0000685_abnormal_immune_system3.05081019
6MP0003300_gastrointestinal_ulcer3.00633741
7MP0001800_abnormal_humoral_immune2.93924680
8MP0005451_abnormal_body_composition2.71002514
9MP0005000_abnormal_immune_tolerance2.62045136
10MP0003436_decreased_susceptibility_to2.61606655
11MP0002452_abnormal_antigen_presenting2.60953149
12MP0002877_abnormal_melanocyte_morpholog2.57044469
13MP0005058_abnormal_lysosome_morphology2.50782580
14MP0004510_myositis2.46360694
15MP0002419_abnormal_innate_immunity2.42351563
16MP0005671_abnormal_response_to2.41645117
17MP0002723_abnormal_immune_serum2.40127638
18MP0002420_abnormal_adaptive_immunity2.37669538
19MP0001819_abnormal_immune_cell2.35606003
20MP0005025_abnormal_response_to2.30036476
21MP0002166_altered_tumor_susceptibility2.26734479
22MP0009278_abnormal_bone_marrow2.23907365
23MP0003763_abnormal_thymus_physiology2.15983231
24MP0000569_abnormal_digit_pigmentation2.10297612
25MP0006082_CNS_inflammation2.09743748
26MP0005464_abnormal_platelet_physiology2.08565133
27MP0009785_altered_susceptibility_to2.02292752
28MP0001873_stomach_inflammation2.01579376
29MP0003191_abnormal_cellular_cholesterol1.99502649
30MP0008260_abnormal_autophagy1.98673755
31MP0002398_abnormal_bone_marrow1.97490202
32MP0002148_abnormal_hypersensitivity_rea1.96150682
33MP0002405_respiratory_system_inflammati1.92162865
34MP0000716_abnormal_immune_system1.92134165
35MP0002396_abnormal_hematopoietic_system1.89842641
36MP0010155_abnormal_intestine_physiology1.83331595
37MP0004858_abnormal_nervous_system1.82404051
38MP0004947_skin_inflammation1.79873018
39MP0003172_abnormal_lysosome_physiology1.77452800
40MP0003724_increased_susceptibility_to1.74516048
41MP0000689_abnormal_spleen_morphology1.72318772
42MP0001849_ear_inflammation1.70411530
43MP0001348_abnormal_lacrimal_gland1.69628530
44MP0003866_abnormal_defecation1.64999555
45MP0005310_abnormal_salivary_gland1.64974305
46MP0002006_tumorigenesis1.63539939
47MP0005670_abnormal_white_adipose1.60338126
48MP0002722_abnormal_immune_system1.58891697
49MP0001845_abnormal_inflammatory_respons1.57216991
50MP0004185_abnormal_adipocyte_glucose1.54542513
51MP0002429_abnormal_blood_cell1.54353889
52MP0000465_gastrointestinal_hemorrhage1.54161111
53MP0002933_joint_inflammation1.52215715
54MP0001533_abnormal_skeleton_physiology1.46794130
55MP0005174_abnormal_tail_pigmentation1.45502223
56MP0003566_abnormal_cell_adhesion1.43221193
57MP0009333_abnormal_splenocyte_physiolog1.40198885
58MP0003183_abnormal_peptide_metabolism1.37850242
59MP0009840_abnormal_foam_cell1.34778305
60MP0000703_abnormal_thymus_morphology1.34163940
61MP0004808_abnormal_hematopoietic_stem1.32558879
62MP0003045_fibrosis1.31991116
63MP0005666_abnormal_adipose_tissue1.29294498
64MP0001853_heart_inflammation1.24443763
65MP0008469_abnormal_protein_level1.15349171
66MP0005076_abnormal_cell_differentiation1.14513187
67MP0001851_eye_inflammation1.14406876
68MP0001545_abnormal_hematopoietic_system1.14271091
69MP0005397_hematopoietic_system_phenotyp1.14271091
70MP0002998_abnormal_bone_remodeling1.13827421
71MP0003828_pulmonary_edema1.13209940
72MP0000751_myopathy1.12951401
73MP0003448_altered_tumor_morphology1.12705958
74MP0003690_abnormal_glial_cell1.11768702
75MP0005409_darkened_coat_color1.09581729
76MP0003091_abnormal_cell_migration1.07610222
77MP0000678_abnormal_parathyroid_gland1.07219391
78MP0004130_abnormal_muscle_cell1.06772386
79MP0008961_abnormal_basal_metabolism1.05646564
80MP0001958_emphysema1.04629218
81MP0000003_abnormal_adipose_tissue1.00725436
82MP0000920_abnormal_myelination0.97532092
83MP0000747_muscle_weakness0.95435813
84MP0005390_skeleton_phenotype0.95351450
85MP0000490_abnormal_crypts_of0.94702994
86MP0005375_adipose_tissue_phenotype0.93355362
87MP0004233_abnormal_muscle_weight0.93004930
88MP0005621_abnormal_cell_physiology0.92386458
89MP0005167_abnormal_blood-brain_barrier0.90894571
90MP0000343_altered_response_to0.90292310
91MP0001915_intracranial_hemorrhage0.89947324
92MP0000759_abnormal_skeletal_muscle0.88255463
93MP0002132_abnormal_respiratory_system0.86275872
94MP0003329_amyloid_beta_deposits0.86263921
95MP0000767_abnormal_smooth_muscle0.86008447
96MP0010352_gastrointestinal_tract_polyps0.85920145
97MP0002254_reproductive_system_inflammat0.85766845
98MP0000015_abnormal_ear_pigmentation0.84842662
99MP0005257_abnormal_intraocular_pressure0.84604695
100MP0003705_abnormal_hypodermis_morpholog0.83135698
101MP0005623_abnormal_meninges_morphology0.82803384
102MP0000858_altered_metastatic_potential0.82501449
103MP0000604_amyloidosis0.82290838
104MP0002136_abnormal_kidney_physiology0.80742537
105MP0000249_abnormal_blood_vessel0.80608356
106MP0003075_altered_response_to0.79907330
107MP0002089_abnormal_postnatal_growth/wei0.79511966
108MP0010368_abnormal_lymphatic_system0.78834479
109MP0002138_abnormal_hepatobiliary_system0.77811225
110MP0003279_aneurysm0.76773264
111MP0005023_abnormal_wound_healing0.76649201
112MP0002249_abnormal_larynx_morphology0.76502688
113MP0000733_abnormal_muscle_development0.76121015
114MP0004087_abnormal_muscle_fiber0.75827395
115MP0001730_embryonic_growth_arrest0.75712716
116MP0008438_abnormal_cutaneous_collagen0.74898913
117MP0003795_abnormal_bone_structure0.74819622
118MP0010307_abnormal_tumor_latency0.71843187
119MP0001663_abnormal_digestive_system0.71381991
120MP0003453_abnormal_keratinocyte_physiol0.69191182
121MP0005166_decreased_susceptibility_to0.68408655
122MP0010630_abnormal_cardiac_muscle0.66373808
123MP0009763_increased_sensitivity_to0.64383342
124MP0009115_abnormal_fat_cell0.62449368
125MP0000371_diluted_coat_color0.62105856
126MP0000609_abnormal_liver_physiology0.61345727
127MP0002928_abnormal_bile_duct0.60182101

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.88576832
2Eczematoid dermatitis (HP:0000976)4.58662970
3Recurrent bacterial skin infections (HP:0005406)4.35018175
4Recurrent viral infections (HP:0004429)4.10093439
5Recurrent fungal infections (HP:0002841)4.09278701
6Inflammation of the large intestine (HP:0002037)3.89537869
7Cellulitis (HP:0100658)3.87882509
8Colitis (HP:0002583)3.85871139
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.73851370
10Gastrointestinal inflammation (HP:0004386)3.70985929
11Chronic otitis media (HP:0000389)3.50807423
12Agammaglobulinemia (HP:0004432)3.43597601
13Spontaneous hematomas (HP:0007420)3.43563774
14Recurrent skin infections (HP:0001581)3.32290020
15Panhypogammaglobulinemia (HP:0003139)3.31796216
16T lymphocytopenia (HP:0005403)3.27331009
17Abnormality of the fingertips (HP:0001211)3.26865765
18Recurrent cutaneous fungal infections (HP:0011370)3.23237409
19Chronic mucocutaneous candidiasis (HP:0002728)3.23237409
20Elevated erythrocyte sedimentation rate (HP:0003565)3.20300300
21Autoimmune thrombocytopenia (HP:0001973)3.17290152
22Abnormality of T cell number (HP:0011839)3.16829183
23IgM deficiency (HP:0002850)3.15068086
24Meningitis (HP:0001287)3.14375171
25Protrusio acetabuli (HP:0003179)3.07327952
26Pustule (HP:0200039)3.05022852
27Hyperacusis (HP:0010780)3.04088886
28Abnormality of macrophages (HP:0004311)3.03177381
29Myositis (HP:0100614)2.99545927
30Chronic obstructive pulmonary disease (HP:0006510)2.93063180
31Obstructive lung disease (HP:0006536)2.93063180
32Papilloma (HP:0012740)2.92822725
33Verrucae (HP:0200043)2.92822725
34Recurrent bronchitis (HP:0002837)2.91263035
35Recurrent gram-negative bacterial infections (HP:0005420)2.90191688
36Gastrointestinal stroma tumor (HP:0100723)2.85478450
37Vacuolated lymphocytes (HP:0001922)2.85471563
38Vasculitis (HP:0002633)2.82255781
39Gingivitis (HP:0000230)2.79772583
40Increased cerebral lipofuscin (HP:0011813)2.74012464
41Mediastinal lymphadenopathy (HP:0100721)2.70960480
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.70825445
43Dysostosis multiplex (HP:0000943)2.68952978
44Increased connective tissue (HP:0009025)2.68828331
45Prolonged bleeding time (HP:0003010)2.68375177
46Vertebral compression fractures (HP:0002953)2.67648165
47Cerebral aneurysm (HP:0004944)2.67140197
48Nasal polyposis (HP:0100582)2.64874167
49Broad face (HP:0000283)2.64443308
50Osteomyelitis (HP:0002754)2.60409040
51Obstructive sleep apnea (HP:0002870)2.57766720
52Emphysema (HP:0002097)2.57247673
53Distal lower limb amyotrophy (HP:0008944)2.56960912
54Abnormality of T cells (HP:0002843)2.56845751
55Thyroiditis (HP:0100646)2.56354832
56Hematochezia (HP:0002573)2.55514407
57Stomatitis (HP:0010280)2.54103457
58Abnormality of the nasal mucosa (HP:0000433)2.54015392
59Systemic lupus erythematosus (HP:0002725)2.46246279
60Periodontitis (HP:0000704)2.42407303
61Increased variability in muscle fiber diameter (HP:0003557)2.38921914
62Eosinophilia (HP:0001880)2.38749316
63Interstitial pulmonary disease (HP:0006530)2.37892597
64Chronic diarrhea (HP:0002028)2.35331564
65Distal lower limb muscle weakness (HP:0009053)2.34726952
66Abnormality of skeletal muscle fiber size (HP:0012084)2.27809593
67Lymphopenia (HP:0001888)2.27804980
68Leukocytosis (HP:0001974)2.27441195
69Increased IgE level (HP:0003212)2.26394254
70Loss of speech (HP:0002371)2.25917571
71Premature rupture of membranes (HP:0001788)2.25318501
72Abnormality of B cell number (HP:0010975)2.24079760
73B lymphocytopenia (HP:0010976)2.24079760
74Gingival bleeding (HP:0000225)2.23396971
75Increased neuronal autofluorescent lipopigment (HP:0002074)2.23077850
76Myocardial infarction (HP:0001658)2.21688204
77Abnormality of cells of the lymphoid lineage (HP:0012140)2.21272276
78Restrictive lung disease (HP:0002091)2.20785860
79Abnormality of T cell physiology (HP:0011840)2.20194891
80Orchitis (HP:0100796)2.19809186
81Achilles tendon contracture (HP:0001771)2.19636140
82Chest pain (HP:0100749)2.17136078
83Abnormal platelet volume (HP:0011876)2.16369575
84Abnormality of the thoracic spine (HP:0100711)2.15071433
85Increased density of long bones (HP:0006392)2.12584247
86Hemorrhage of the eye (HP:0011885)2.09524607
87Ulnar bowing (HP:0003031)2.09523569
88Axonal loss (HP:0003447)2.08859944
89Disproportionate tall stature (HP:0001519)2.08219629
90Epistaxis (HP:0000421)2.07018671
91Dilatation of the ascending aorta (HP:0005111)2.06472581
92Urinary glycosaminoglycan excretion (HP:0003541)2.06159599
93Mucopolysacchariduria (HP:0008155)2.06159599
94Abnormality of glycolipid metabolism (HP:0010969)2.05767196
95Abnormality of liposaccharide metabolism (HP:0010968)2.05767196
96Abnormality of glycosphingolipid metabolism (HP:0004343)2.05767196
97Arterial thrombosis (HP:0004420)2.05355148
98Sepsis (HP:0100806)2.05053878
99Retrobulbar optic neuritis (HP:0100654)2.04728727
100Optic neuritis (HP:0100653)2.04728727
101Recurrent sinusitis (HP:0011108)2.04600176
102Hemoptysis (HP:0002105)2.03326016
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01011884
104Abnormality of polysaccharide metabolism (HP:0011012)2.01011884
105Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01011884
106Mitral regurgitation (HP:0001653)2.00989991
107Aneurysm (HP:0002617)1.99700221
108Severe combined immunodeficiency (HP:0004430)1.98842405
109Pulmonary infiltrates (HP:0002113)1.98696382
110Difficulty climbing stairs (HP:0003551)1.98391728
111IgA deficiency (HP:0002720)1.98127144
112Polygenic inheritance (HP:0010982)1.97719450
113Easy fatigability (HP:0003388)1.96428213
114Distal upper limb amyotrophy (HP:0007149)1.95873393
115Upper limb amyotrophy (HP:0009129)1.95873393
116Thoracic kyphosis (HP:0002942)1.94081978
117Granulocytopenia (HP:0001913)1.93805688
118Glomerulonephritis (HP:0000099)1.92122500
119Polycythemia (HP:0001901)1.91920895
120Gastrointestinal infarctions (HP:0005244)1.91278886
121Abnormality of eosinophils (HP:0001879)1.91077909
122Recurrent pneumonia (HP:0006532)1.90550806
123Fatigue (HP:0012378)1.90159393
124Stridor (HP:0010307)1.90078776
125Hypertensive crisis (HP:0100735)1.90012422
126Long palpebral fissure (HP:0000637)1.89818858
127Segmental peripheral demyelination/remyelination (HP:0003481)1.89814641
128Frequent falls (HP:0002359)1.89708191
129Combined immunodeficiency (HP:0005387)1.89278692
130Osteolytic defects of the hand bones (HP:0009699)1.88040460
131Abnormality of the Achilles tendon (HP:0005109)1.87407628
132Asymmetry of the thorax (HP:0001555)1.84584368
133Blue sclerae (HP:0000592)1.82254484
134Cervical subluxation (HP:0003308)1.80610105
135Premature skin wrinkling (HP:0100678)1.80605937
136Spinal rigidity (HP:0003306)1.79016103
137Shallow orbits (HP:0000586)1.78191182
138Biconcave vertebral bodies (HP:0004586)1.76944344
139Insomnia (HP:0100785)1.76256166
140Upper motor neuron abnormality (HP:0002127)1.75897303
141J-shaped sella turcica (HP:0002680)1.73966829
142Amyloidosis (HP:0011034)1.73755440
143Thin bony cortex (HP:0002753)1.72875240
144Hypertriglyceridemia (HP:0002155)1.71846742
145Asymmetric septal hypertrophy (HP:0001670)1.71183048
146Slow saccadic eye movements (HP:0000514)1.70949778
147Genu recurvatum (HP:0002816)1.70290334
148Lower limb amyotrophy (HP:0007210)1.70277018
149Spinal cord lesions (HP:0100561)1.69703337
150Syringomyelia (HP:0003396)1.69703337
151Spondylolisthesis (HP:0003302)1.69670281
152Flat acetabular roof (HP:0003180)1.68654587
153Broad distal phalanx of finger (HP:0009836)1.64895439
154Purpura (HP:0000979)1.64075409
155Increased serum ferritin (HP:0003281)1.63056669
156Fragile skin (HP:0001030)1.62727843

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.28175719
2PRPF4B3.55057608
3SMG13.19151810
4MAP3K102.76866238
5BLK2.74823913
6EPHB12.56829333
7TRIB32.46388458
8EEF2K2.40358881
9TYK22.25995909
10TBK12.18436997
11GRK62.16604289
12MAP3K142.14043683
13TAOK31.94520876
14TTN1.94438490
15ERN11.89709863
16JAK31.88105914
17PKN21.87913594
18TGFBR21.86186386
19TXK1.82975721
20IKBKE1.81185433
21STK101.80213301
22RIPK41.79504169
23JAK11.77711090
24CSK1.75810377
25CSF1R1.73014439
26ZAP701.66042352
27ITK1.65565498
28SIK21.64276481
29CAMK1D1.64029427
30CAMK1G1.57711397
31HCK1.57479317
32FES1.55776788
33BTK1.55230112
34CLK11.54947990
35MAP3K131.51882168
36NME21.51850789
37DMPK1.48780209
38KIT1.45544992
39MAP3K111.45542066
40IRAK41.43504535
41PTK61.39721918
42TAOK21.37488989
43FGFR41.35858586
44CDK121.33598948
45SYK1.29687384
46LCK1.29048558
47IKBKB1.28395761
48TESK21.27279513
49PRKD31.23066112
50LRRK21.20027154
51MAP3K31.18004655
52TEC1.15709809
53IRAK21.08405021
54SIK31.05965506
55SIK11.03512518
56TRPM71.03052647
57KSR21.02737810
58MAP2K31.01324123
59TAOK10.99841322
60FGFR30.99567997
61FGR0.99316510
62TESK10.96327786
63MAP3K10.95552227
64MAP3K70.94038554
65PRKCH0.92552555
66IRAK30.91126850
67PDGFRA0.90661863
68ARAF0.87513170
69PRKCQ0.87428920
70CDC42BPA0.87152861
71PDGFRB0.86573399
72MARK30.86469265
73MAP3K60.85529039
74PIM10.84309129
75JAK20.83228014
76LYN0.82902660
77MST40.82203539
78EPHA20.81430100
79STK40.75367473
80CHUK0.74984106
81ICK0.71822560
82MAP2K20.71393648
83MAP3K80.70298333
84MOS0.70042371
85PRKD20.67876692
86CAMKK10.67859109
87MARK20.67245012
88RIPK10.65885059
89PRKD10.64228388
90MAPK120.59686231
91TNK20.58524391
92BRAF0.57654910
93BRD40.55457940
94PRKAA20.53499991
95MAPK70.53383435
96RET0.52709832
97PTK20.52471015
98FYN0.52234594
99NUAK10.51926434
100BMX0.51192415
101CDK40.51153931
102HIPK20.50843487
103RPS6KA60.50809822
104STK380.50763458
105PASK0.49381132
106PRKG20.48120480
107SGK30.48110309
108* PDK10.47845514
109CDK90.46868762
110FGFR20.45595939
111ALK0.44114637
112PAK40.43414461
113CDK70.43010760
114MTOR0.42860356
115RPS6KL10.42689614
116RPS6KC10.42689614
117WNK10.42570615
118ABL10.41695988
119CDK60.41077655
120INSR0.40475836
121EGFR0.40355645
122NLK0.40075049
123ILK0.40042731
124LMTK20.39508804
125EPHA30.38888018
126* PDPK10.38056873
127KDR0.37228239
128IRAK10.36727266
129MAPK110.35353013
130MAPK40.34953022
131NTRK10.32884408
132RPS6KA20.32521389
133MAPKAPK20.31947248
134SRC0.31358103
135PAK20.31265652
136MELK0.30933990

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046623.04518956
2Primary immunodeficiency_Homo sapiens_hsa053403.00685608
3Osteoclast differentiation_Homo sapiens_hsa043802.60342497
4Leishmaniasis_Homo sapiens_hsa051402.38458887
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.25915927
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.19192096
7Staphylococcus aureus infection_Homo sapiens_hsa051502.16049077
8T cell receptor signaling pathway_Homo sapiens_hsa046602.01938047
9Measles_Homo sapiens_hsa051621.94752070
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.91942709
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86439953
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77419846
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.72271284
14Hematopoietic cell lineage_Homo sapiens_hsa046401.71573981
15Other glycan degradation_Homo sapiens_hsa005111.68864807
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66671967
17Chemokine signaling pathway_Homo sapiens_hsa040621.62190426
18Toxoplasmosis_Homo sapiens_hsa051451.61107002
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56940734
20Chronic myeloid leukemia_Homo sapiens_hsa052201.52314157
21Acute myeloid leukemia_Homo sapiens_hsa052211.51413938
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.46642531
23Viral myocarditis_Homo sapiens_hsa054161.38950754
24Tuberculosis_Homo sapiens_hsa051521.38615469
25Bladder cancer_Homo sapiens_hsa052191.38398718
26Platelet activation_Homo sapiens_hsa046111.36627933
27Pancreatic cancer_Homo sapiens_hsa052121.34550920
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34125490
29Antigen processing and presentation_Homo sapiens_hsa046121.34060417
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.32669939
31Malaria_Homo sapiens_hsa051441.29833692
32Pertussis_Homo sapiens_hsa051331.29706204
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29356535
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.28972762
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28668271
36Lysosome_Homo sapiens_hsa041421.25899120
37TNF signaling pathway_Homo sapiens_hsa046681.21737782
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20752134
39Pentose phosphate pathway_Homo sapiens_hsa000301.20623198
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19929760
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19458193
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18435797
43Apoptosis_Homo sapiens_hsa042101.18222825
44Influenza A_Homo sapiens_hsa051641.17887375
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11920738
46Hepatitis B_Homo sapiens_hsa051611.05960083
47Prion diseases_Homo sapiens_hsa050201.03790138
48Hepatitis C_Homo sapiens_hsa051601.02294478
49Lysine degradation_Homo sapiens_hsa003101.01050739
50Herpes simplex infection_Homo sapiens_hsa051681.00079675
51Thyroid cancer_Homo sapiens_hsa052160.99662382
52Shigellosis_Homo sapiens_hsa051310.99469878
53Insulin signaling pathway_Homo sapiens_hsa049100.97612114
54Non-small cell lung cancer_Homo sapiens_hsa052230.96736280
55VEGF signaling pathway_Homo sapiens_hsa043700.94631711
56Small cell lung cancer_Homo sapiens_hsa052220.94513126
57ErbB signaling pathway_Homo sapiens_hsa040120.93916230
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93611185
59Insulin resistance_Homo sapiens_hsa049310.92685752
60GnRH signaling pathway_Homo sapiens_hsa049120.92573208
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90867532
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89261585
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88795366
64* Salmonella infection_Homo sapiens_hsa051320.86490837
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86076477
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85254198
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.84961255
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.84896989
69Renal cell carcinoma_Homo sapiens_hsa052110.84847995
70Notch signaling pathway_Homo sapiens_hsa043300.84076200
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84069290
72Fructose and mannose metabolism_Homo sapiens_hsa000510.82955844
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81259017
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80702469
75Legionellosis_Homo sapiens_hsa051340.79856225
76Graft-versus-host disease_Homo sapiens_hsa053320.78037156
77Focal adhesion_Homo sapiens_hsa045100.77751969
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77745902
79Type II diabetes mellitus_Homo sapiens_hsa049300.77191110
80Caffeine metabolism_Homo sapiens_hsa002320.76876880
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.76491947
82Amoebiasis_Homo sapiens_hsa051460.75218718
83Estrogen signaling pathway_Homo sapiens_hsa049150.74922121
84Allograft rejection_Homo sapiens_hsa053300.73735256
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73263627
86Epstein-Barr virus infection_Homo sapiens_hsa051690.73161366
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72126503
88Prolactin signaling pathway_Homo sapiens_hsa049170.71507641
89Endocytosis_Homo sapiens_hsa041440.70931880
90Galactose metabolism_Homo sapiens_hsa000520.70265957
91Inositol phosphate metabolism_Homo sapiens_hsa005620.68739097
92ABC transporters_Homo sapiens_hsa020100.68048273
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.67174054
94Proteoglycans in cancer_Homo sapiens_hsa052050.64264901
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63736353
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63206290
97Viral carcinogenesis_Homo sapiens_hsa052030.62552938
98Dorso-ventral axis formation_Homo sapiens_hsa043200.61772647
99Choline metabolism in cancer_Homo sapiens_hsa052310.60861898
100AMPK signaling pathway_Homo sapiens_hsa041520.58786909
101HTLV-I infection_Homo sapiens_hsa051660.57633664
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57272501
103Colorectal cancer_Homo sapiens_hsa052100.57170835
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56500356
105mTOR signaling pathway_Homo sapiens_hsa041500.55213876
106MAPK signaling pathway_Homo sapiens_hsa040100.54422602
107HIF-1 signaling pathway_Homo sapiens_hsa040660.53769437
108Prostate cancer_Homo sapiens_hsa052150.53427775
109Rap1 signaling pathway_Homo sapiens_hsa040150.52691351
110MicroRNAs in cancer_Homo sapiens_hsa052060.50546455
111FoxO signaling pathway_Homo sapiens_hsa040680.50503194
112Endometrial cancer_Homo sapiens_hsa052130.49900446
113Rheumatoid arthritis_Homo sapiens_hsa053230.48692882
114Adherens junction_Homo sapiens_hsa045200.46756416
115Autoimmune thyroid disease_Homo sapiens_hsa053200.46221285
116Phagosome_Homo sapiens_hsa041450.44229976
117Pathways in cancer_Homo sapiens_hsa052000.43295030
118Glioma_Homo sapiens_hsa052140.43264383
119Asthma_Homo sapiens_hsa053100.41589049

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