PKD2L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.82702589
2regulation of female gonad development (GO:2000194)6.63367419
3mitotic metaphase plate congression (GO:0007080)6.55311802
4regulation of meiosis (GO:0040020)6.26050325
5attachment of spindle microtubules to kinetochore (GO:0008608)6.07446021
6female gamete generation (GO:0007292)5.92622792
7regulation of meiosis I (GO:0060631)5.87433957
8negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.82451110
9regulation of exit from mitosis (GO:0007096)5.66680548
10behavioral response to nicotine (GO:0035095)5.65775917
11meiotic cell cycle (GO:0051321)5.63406262
12male meiosis (GO:0007140)5.53871029
13mitotic chromosome condensation (GO:0007076)5.47015317
14negative regulation of meiosis (GO:0045835)5.46700219
15metaphase plate congression (GO:0051310)5.44486448
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.43023062
17histone H2A monoubiquitination (GO:0035518)5.30938738
18establishment of chromosome localization (GO:0051303)5.16963675
19meiotic chromosome segregation (GO:0045132)5.14383198
20oocyte maturation (GO:0001556)5.14355785
21DNA methylation involved in gamete generation (GO:0043046)5.02442208
22maturation of 5.8S rRNA (GO:0000460)4.97881782
23regulation of meiotic cell cycle (GO:0051445)4.93682163
24DNA damage induced protein phosphorylation (GO:0006975)4.80619800
25mitotic sister chromatid segregation (GO:0000070)4.78700133
26regulation of sister chromatid cohesion (GO:0007063)4.78400814
27negative regulation of hormone biosynthetic process (GO:0032353)4.74871522
28negative regulation of hormone metabolic process (GO:0032351)4.74871522
29regulation of retinoic acid receptor signaling pathway (GO:0048385)4.61506496
30DNA deamination (GO:0045006)4.60926922
31histone H2A ubiquitination (GO:0033522)4.56461420
32monoubiquitinated protein deubiquitination (GO:0035520)4.54291285
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.46738891
34regulation of RIG-I signaling pathway (GO:0039535)4.38058623
35regulation of histone H3-K27 methylation (GO:0061085)4.18626533
36glycerophospholipid catabolic process (GO:0046475)4.15966627
37protein K6-linked ubiquitination (GO:0085020)4.14012093
38DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.10817303
39DNA damage response, signal transduction resulting in transcription (GO:0042772)4.07687861
40negative regulation of smooth muscle cell differentiation (GO:0051151)4.06998977
41response to pheromone (GO:0019236)4.04081490
42chromosome segregation (GO:0007059)4.02386100
43L-fucose catabolic process (GO:0042355)3.98074696
44fucose catabolic process (GO:0019317)3.98074696
45L-fucose metabolic process (GO:0042354)3.98074696
46female gonad development (GO:0008585)3.97169636
47regulation of spindle organization (GO:0090224)3.96369206
48regulation of transforming growth factor beta2 production (GO:0032909)3.93680955
49protein localization to chromosome, centromeric region (GO:0071459)3.93352924
50protein localization to kinetochore (GO:0034501)3.92360948
51protein localization to chromosome (GO:0034502)3.90812067
52positive regulation of megakaryocyte differentiation (GO:0045654)3.88779076
53CENP-A containing nucleosome assembly (GO:0034080)3.88004017
54sister chromatid segregation (GO:0000819)3.82752153
55epithelial cilium movement (GO:0003351)3.81178179
56negative regulation of meiotic cell cycle (GO:0051447)3.79488482
57positive regulation of chromosome segregation (GO:0051984)3.78334014
58regulation of DNA methylation (GO:0044030)3.75903696
59chromatin remodeling at centromere (GO:0031055)3.75108523
60type B pancreatic cell development (GO:0003323)3.72867577
61regulation of glucocorticoid metabolic process (GO:0031943)3.72002248
62microtubule severing (GO:0051013)3.68226622
63regulation of mitotic spindle organization (GO:0060236)3.67591323
64regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.66260687
65spindle checkpoint (GO:0031577)3.65400989
66negative regulation of DNA-templated transcription, elongation (GO:0032785)3.64330556
67negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.64330556
68gene silencing by RNA (GO:0031047)3.64203422
69detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.62905635
70histone exchange (GO:0043486)3.62381459
71microtubule nucleation (GO:0007020)3.61390907
72regulation of chromosome segregation (GO:0051983)3.59693291
73indolalkylamine metabolic process (GO:0006586)3.58154121
74DNA replication-independent nucleosome assembly (GO:0006336)3.54784213
75DNA replication-independent nucleosome organization (GO:0034724)3.54784213
76meiotic nuclear division (GO:0007126)3.50581674
77positive regulation of mitotic sister chromatid separation (GO:1901970)3.49722095
78positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49722095
79positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49722095
80multicellular organism reproduction (GO:0032504)3.48045899
81regulation of acrosome reaction (GO:0060046)3.45033782
82platelet dense granule organization (GO:0060155)3.43740613
83indole-containing compound catabolic process (GO:0042436)3.43502743
84indolalkylamine catabolic process (GO:0046218)3.43502743
85tryptophan catabolic process (GO:0006569)3.43502743
86DNA alkylation (GO:0006305)3.42098256
87DNA methylation (GO:0006306)3.42098256
88negative regulation of cell division (GO:0051782)3.36754231
89regulation of cell maturation (GO:1903429)3.34553308
90mitotic sister chromatid cohesion (GO:0007064)3.34351635
91detection of light stimulus involved in sensory perception (GO:0050962)3.32436191
92detection of light stimulus involved in visual perception (GO:0050908)3.32436191
93negative regulation of reproductive process (GO:2000242)3.32343886
94male meiosis I (GO:0007141)3.31156231
95meiosis I (GO:0007127)3.30528327
96sister chromatid cohesion (GO:0007062)3.28757013
97myoblast migration (GO:0051451)3.28740688
98snRNA transcription (GO:0009301)3.28166380
99meiotic cell cycle process (GO:1903046)3.27162162
100notochord development (GO:0030903)3.26976213
101negative regulation of keratinocyte proliferation (GO:0010839)3.26490584
102mitotic nuclear envelope disassembly (GO:0007077)3.25101934
103regulation of cilium movement (GO:0003352)3.24061290
104mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23832352
105mitochondrial respiratory chain complex I assembly (GO:0032981)3.23832352
106NADH dehydrogenase complex assembly (GO:0010257)3.23832352
107synaptonemal complex assembly (GO:0007130)3.22962229
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22876119
109axoneme assembly (GO:0035082)3.22851557
110protein polyglutamylation (GO:0018095)3.22372343
111positive regulation of DNA-dependent DNA replication (GO:2000105)3.20509740
112positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.19634772
113regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18439287
114sphingosine metabolic process (GO:0006670)3.16774615
115negative regulation of nuclear division (GO:0051784)3.16444724
116oogenesis (GO:0048477)3.16293782
117tryptophan metabolic process (GO:0006568)3.14439803
118mitotic spindle checkpoint (GO:0071174)3.13372440
119regulation of double-strand break repair via homologous recombination (GO:0010569)3.09513343
120DNA replication checkpoint (GO:0000076)3.09163065
121chaperone-mediated protein transport (GO:0072321)3.09080576
122neuronal action potential (GO:0019228)3.08568294
123membrane disassembly (GO:0030397)3.07776438
124nuclear envelope disassembly (GO:0051081)3.07776438
125reciprocal DNA recombination (GO:0035825)3.07351260
126reciprocal meiotic recombination (GO:0007131)3.07351260
127negative regulation of mast cell activation (GO:0033004)3.07210311
128protein complex biogenesis (GO:0070271)3.07109981
129nonmotile primary cilium assembly (GO:0035058)3.07019175
130protein-cofactor linkage (GO:0018065)3.02925273
131negative regulation of telomere maintenance (GO:0032205)3.00755886
132centriole replication (GO:0007099)2.98487276
133kidney morphogenesis (GO:0060993)2.98338146
134cilium movement (GO:0003341)2.98124038
135nephron epithelium morphogenesis (GO:0072088)2.97191241
136nephron tubule morphogenesis (GO:0072078)2.97191241
137kynurenine metabolic process (GO:0070189)2.93614959
138mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.92222289
139reflex (GO:0060004)2.91894351
140mitochondrial respiratory chain complex assembly (GO:0033108)2.88600911
141cellular ketone body metabolic process (GO:0046950)2.88426022
142water-soluble vitamin biosynthetic process (GO:0042364)2.88008567
143regulation of glucokinase activity (GO:0033131)2.87841956
144regulation of hexokinase activity (GO:1903299)2.87841956
145cornea development in camera-type eye (GO:0061303)2.84388217
146sperm motility (GO:0030317)2.82685450
147cilium or flagellum-dependent cell motility (GO:0001539)2.80620379
148adaptation of signaling pathway (GO:0023058)2.76437509
149cilium morphogenesis (GO:0060271)2.74554254
150negative regulation of transcription regulatory region DNA binding (GO:2000678)2.73629664
151amine catabolic process (GO:0009310)2.73557138
152cellular biogenic amine catabolic process (GO:0042402)2.73557138
153preassembly of GPI anchor in ER membrane (GO:0016254)2.70734573
154retinal cone cell development (GO:0046549)2.70613369
155indole-containing compound metabolic process (GO:0042430)2.69456239
156ketone body metabolic process (GO:1902224)2.67322788
157peptidyl-histidine modification (GO:0018202)2.63796002
158gamma-aminobutyric acid transport (GO:0015812)2.63010613
159respiratory chain complex IV assembly (GO:0008535)2.62922150
160photoreceptor cell maintenance (GO:0045494)2.62665887
161cilium organization (GO:0044782)2.61685777
162cytidine metabolic process (GO:0046087)2.60764694
163cytidine catabolic process (GO:0006216)2.60764694
164cytidine deamination (GO:0009972)2.60764694
165sulfation (GO:0051923)2.60090121
166tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59821129
167RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59821129
168regulation of microtubule-based movement (GO:0060632)2.59231851
169ubiquinone biosynthetic process (GO:0006744)2.57905426
170protein import into peroxisome matrix (GO:0016558)2.57595028
171somite development (GO:0061053)2.57142152
172negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.55118257
173L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55083193
174negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54380271
175mannosylation (GO:0097502)2.53800977
176axonemal dynein complex assembly (GO:0070286)2.53203722
177anterograde synaptic vesicle transport (GO:0048490)2.53060881
178recombinational repair (GO:0000725)2.52683037
179negative regulation of reactive oxygen species metabolic process (GO:2000378)2.51652451
180cilium assembly (GO:0042384)2.51157200
181rhodopsin mediated signaling pathway (GO:0016056)2.50528934
182synapsis (GO:0007129)2.50475289
183pseudouridine synthesis (GO:0001522)2.48849171
184regulation of action potential (GO:0098900)2.48345909
185regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.46185265
186regulation of rhodopsin mediated signaling pathway (GO:0022400)2.45429727
187primary amino compound metabolic process (GO:1901160)2.44863565
188pyrimidine nucleobase catabolic process (GO:0006208)2.43685721
189acrosome reaction (GO:0007340)2.43366912
190double-strand break repair via homologous recombination (GO:0000724)2.42805173
191cytochrome complex assembly (GO:0017004)2.41940613
192photoreceptor cell development (GO:0042461)2.41801152
193DNA double-strand break processing (GO:0000729)2.37738437
194synaptic transmission, cholinergic (GO:0007271)2.37096742
195ubiquinone metabolic process (GO:0006743)2.36149581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.75705764
2SMAD_19615063_ChIP-ChIP_OVARY_Human4.45339227
3ZNF274_21170338_ChIP-Seq_K562_Hela3.96928074
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.96286697
5* KAP1_22055183_ChIP-Seq_ESCs_Mouse3.83075827
6E2F7_22180533_ChIP-Seq_HELA_Human3.74863072
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.53578254
8EZH2_22144423_ChIP-Seq_EOC_Human3.37173385
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.33391634
10AR_21909140_ChIP-Seq_LNCAP_Human3.11761929
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.77513879
12GBX2_23144817_ChIP-Seq_PC3_Human2.76799512
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44954132
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44566861
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.38554141
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.34179367
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21770499
18IGF1R_20145208_ChIP-Seq_DFB_Human2.21579640
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19851675
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18203605
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13353451
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.08213368
23P300_19829295_ChIP-Seq_ESCs_Human1.98418695
24ER_23166858_ChIP-Seq_MCF-7_Human1.90722210
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89602144
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84859665
27TAF15_26573619_Chip-Seq_HEK293_Human1.84622388
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82268094
29LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79626463
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79550258
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78344462
32RUNX1_26923725_Chip-Seq_HPCs_Mouse1.74743576
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72775798
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.69622466
35MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.68918379
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66503799
37TP53_22573176_ChIP-Seq_HFKS_Human1.64081711
38FUS_26573619_Chip-Seq_HEK293_Human1.63196891
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.62909687
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60930205
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59995182
42BCAT_22108803_ChIP-Seq_LS180_Human1.58699563
43* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58675080
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57271324
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.52830156
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52397386
47RNF2_27304074_Chip-Seq_NSC_Mouse1.51316312
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47422376
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.47191383
50MYC_18940864_ChIP-ChIP_HL60_Human1.45635234
51IRF1_19129219_ChIP-ChIP_H3396_Human1.44762186
52TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.44222419
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.43630239
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42529646
55CBP_20019798_ChIP-Seq_JUKART_Human1.42529646
56STAT1_17558387_ChIP-Seq_HELA_Human1.42280404
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.42240596
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39214276
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.39130613
60NANOG_19829295_ChIP-Seq_ESCs_Human1.38708914
61SOX2_19829295_ChIP-Seq_ESCs_Human1.38708914
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38603103
63AR_25329375_ChIP-Seq_VCAP_Human1.38573083
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38290477
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.37321166
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.33734339
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33734339
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33008661
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32769058
70CDX2_22108803_ChIP-Seq_LS180_Human1.32616881
71TCF4_23295773_ChIP-Seq_U87_Human1.32033341
72* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31964613
73REST_21632747_ChIP-Seq_MESCs_Mouse1.31823548
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31642724
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.30036638
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.29787916
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.29275273
78AR_21572438_ChIP-Seq_LNCaP_Human1.29258415
79FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28652056
80CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.28152716
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28070937
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27570604
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27214708
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26881364
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26200657
86STAT3_23295773_ChIP-Seq_U87_Human1.25528774
87TCF4_22108803_ChIP-Seq_LS180_Human1.25499417
88KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23030609
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.20915631
90NCOR_22424771_ChIP-Seq_293T_Human1.20029944
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19526169
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19526169
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19474484
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19298648
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18998128
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18767079
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18591953
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17217754
99GATA3_21867929_ChIP-Seq_TH1_Mouse1.16797719
100ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16539453
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15533219
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14820147
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14765674
104EWS_26573619_Chip-Seq_HEK293_Human1.14604701
105SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14601292
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13470156
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.13135648
108RUNX2_22187159_ChIP-Seq_PCA_Human1.12638892
109ESR1_20079471_ChIP-ChIP_T-47D_Human1.12549670
110AR_20517297_ChIP-Seq_VCAP_Human1.12307165
111AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11314874
112VDR_23849224_ChIP-Seq_CD4+_Human1.11185431
113KDM2B_26808549_Chip-Seq_REH_Human1.10578516
114EZH2_27294783_Chip-Seq_NPCs_Mouse1.10403159
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.09394404
116ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09076387
117NFE2_27457419_Chip-Seq_LIVER_Mouse1.08466988
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08415142
119HOXB7_26014856_ChIP-Seq_BT474_Human1.08084644
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06850529
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06539356
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05959501
123NFYA_21822215_ChIP-Seq_K562_Human1.05452281
124ELK1_19687146_ChIP-ChIP_HELA_Human1.05246624
125CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04941465
126CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04296464
127STAT3_18555785_Chip-Seq_ESCs_Mouse1.04172843
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01976350
129MYC_19829295_ChIP-Seq_ESCs_Human1.01641921
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01411259
131TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01133363
132ERA_21632823_ChIP-Seq_H3396_Human1.00975531
133TAL1_26923725_Chip-Seq_HPCs_Mouse1.00895970
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99949161
135NANOG_20526341_ChIP-Seq_ESCs_Human0.99780411
136EED_16625203_ChIP-ChIP_MESCs_Mouse0.99591673
137KLF4_18555785_Chip-Seq_ESCs_Mouse0.99564036
138ERG_20517297_ChIP-Seq_VCAP_Human0.99446797
139SOX2_18555785_Chip-Seq_ESCs_Mouse0.99079312
140PRDM14_20953172_ChIP-Seq_ESCs_Human0.98796603
141FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98649571
142CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98588503
143EP300_21415370_ChIP-Seq_HL-1_Mouse0.97550979
144IRF8_22096565_ChIP-ChIP_GC-B_Human0.97502534
145GF1B_26923725_Chip-Seq_HPCs_Mouse0.97002495
146EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96884012
147TBL1_22424771_ChIP-Seq_293T_Human0.96770313
148CRX_20693478_ChIP-Seq_RETINA_Mouse0.96766193
149SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96375563
150LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96017841
151CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95723531
152CTCF_18555785_Chip-Seq_ESCs_Mouse0.94882587
153NMYC_18555785_Chip-Seq_ESCs_Mouse0.94168866
154VDR_22108803_ChIP-Seq_LS180_Human0.91692732
155CMYC_18555785_Chip-Seq_ESCs_Mouse0.90882492
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90156973
157EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89719749
158OCT4_18555785_Chip-Seq_ESCs_Mouse0.88897601
159SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.88752001
160ZFX_18555785_Chip-Seq_ESCs_Mouse0.88695806
161ESRRB_18555785_Chip-Seq_ESCs_Mouse0.87159031
162NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87156333
163CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86866048
164SMAD4_21799915_ChIP-Seq_A2780_Human0.86826280
165FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86043506
166FOXH1_21741376_ChIP-Seq_EPCs_Human0.85088840
167MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84839427
168NANOG_21062744_ChIP-ChIP_HESCs_Human0.83543551

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.70792405
2MP0003646_muscle_fatigue5.57287338
3MP0005451_abnormal_body_composition5.21317398
4MP0002102_abnormal_ear_morphology4.69124387
5MP0008877_abnormal_DNA_methylation4.14021707
6MP0003693_abnormal_embryo_hatching4.07727351
7MP0002653_abnormal_ependyma_morphology3.64836807
8MP0010094_abnormal_chromosome_stability3.20540125
9MP0000569_abnormal_digit_pigmentation3.04605437
10MP0003111_abnormal_nucleus_morphology2.87818064
11MP0003787_abnormal_imprinting2.84566293
12MP0003077_abnormal_cell_cycle2.80154624
13MP0001119_abnormal_female_reproductive2.74835670
14MP0003699_abnormal_female_reproductive2.68522697
15MP0005395_other_phenotype2.66932840
16MP0003136_yellow_coat_color2.60747616
17MP0005408_hypopigmentation2.55137839
18MP0001929_abnormal_gametogenesis2.49415458
19MP0005551_abnormal_eye_electrophysiolog2.46391036
20MP0004957_abnormal_blastocyst_morpholog2.45914545
21MP0006292_abnormal_olfactory_placode2.37467543
22MP0003123_paternal_imprinting2.32943289
23MP0000653_abnormal_sex_gland2.26787637
24MP0002210_abnormal_sex_determination2.15396961
25MP0005645_abnormal_hypothalamus_physiol2.07397316
26MP0003121_genomic_imprinting2.07210264
27MP0003195_calcinosis2.01598128
28MP0001968_abnormal_touch/_nociception2.00150490
29MP0004147_increased_porphyrin_level1.97139632
30MP0009046_muscle_twitch1.96317699
31MP0003880_abnormal_central_pattern1.96309239
32MP0002249_abnormal_larynx_morphology1.94438140
33MP0004142_abnormal_muscle_tone1.93704765
34MP0002638_abnormal_pupillary_reflex1.91412816
35MP0008872_abnormal_physiological_respon1.90609504
36MP0001986_abnormal_taste_sensitivity1.88565829
37MP0008875_abnormal_xenobiotic_pharmacok1.86439836
38MP0005646_abnormal_pituitary_gland1.86433998
39MP0006072_abnormal_retinal_apoptosis1.85905978
40MP0003937_abnormal_limbs/digits/tail_de1.82978016
41MP0000579_abnormal_nail_morphology1.81992326
42MP0000372_irregular_coat_pigmentation1.81875559
43MP0002837_dystrophic_cardiac_calcinosis1.77053179
44MP0009745_abnormal_behavioral_response1.76631818
45MP0005174_abnormal_tail_pigmentation1.74920775
46MP0002876_abnormal_thyroid_physiology1.74551718
47MP0006276_abnormal_autonomic_nervous1.71520396
48MP0005253_abnormal_eye_physiology1.66701468
49MP0008932_abnormal_embryonic_tissue1.66147544
50MP0001984_abnormal_olfaction1.65601492
51MP0001145_abnormal_male_reproductive1.61641041
52MP0008007_abnormal_cellular_replicative1.61500143
53MP0001529_abnormal_vocalization1.61253692
54MP0005084_abnormal_gallbladder_morpholo1.60782828
55MP0002272_abnormal_nervous_system1.60500756
56MP0004043_abnormal_pH_regulation1.60285676
57MP0001485_abnormal_pinna_reflex1.55912106
58MP0002161_abnormal_fertility/fecundity1.53855164
59MP0002736_abnormal_nociception_after1.52151354
60MP0005410_abnormal_fertilization1.45258154
61MP0003315_abnormal_perineum_morphology1.44351153
62MP0001486_abnormal_startle_reflex1.41771944
63MP0002938_white_spotting1.40637858
64MP0002095_abnormal_skin_pigmentation1.38953876
65MP0001905_abnormal_dopamine_level1.36793795
66MP0004885_abnormal_endolymph1.35336954
67MP0004742_abnormal_vestibular_system1.34766655
68MP0010368_abnormal_lymphatic_system1.31719289
69MP0004264_abnormal_extraembryonic_tissu1.31665617
70MP0001501_abnormal_sleep_pattern1.31489139
71MP0002735_abnormal_chemical_nociception1.31221109
72MP0002572_abnormal_emotion/affect_behav1.30617078
73MP0004133_heterotaxia1.30368095
74MP0000639_abnormal_adrenal_gland1.28770802
75MP0002877_abnormal_melanocyte_morpholog1.24293516
76MP0002160_abnormal_reproductive_system1.24207463
77MP0003011_delayed_dark_adaptation1.24026396
78MP0005075_abnormal_melanosome_morpholog1.23787943
79MP0002064_seizures1.23527336
80MP0002085_abnormal_embryonic_tissue1.23432652
81MP0000350_abnormal_cell_proliferation1.22999391
82MP0002234_abnormal_pharynx_morphology1.22191114
83MP0010386_abnormal_urinary_bladder1.20531735
84MP0000462_abnormal_digestive_system1.20156531
85MP0005310_abnormal_salivary_gland1.18651536
86MP0002557_abnormal_social/conspecific_i1.16953292
87MP0008995_early_reproductive_senescence1.14321863
88MP0002928_abnormal_bile_duct1.13590658
89MP0002067_abnormal_sensory_capabilities1.13476588
90MP0003656_abnormal_erythrocyte_physiolo1.12965523
91MP0005386_behavior/neurological_phenoty1.12781638
92MP0004924_abnormal_behavior1.12781638
93MP0001970_abnormal_pain_threshold1.12541133
94MP0001697_abnormal_embryo_size1.10934726
95MP0001730_embryonic_growth_arrest1.10925704
96MP0001915_intracranial_hemorrhage1.10788825
97MP0003698_abnormal_male_reproductive1.08053209
98MP0001502_abnormal_circadian_rhythm1.07663168
99MP0002733_abnormal_thermal_nociception1.07403750
100MP0002063_abnormal_learning/memory/cond1.03832821
101MP0003950_abnormal_plasma_membrane1.03089018
102MP0005167_abnormal_blood-brain_barrier1.01350115
103MP0005195_abnormal_posterior_eye1.00091058
104MP0004215_abnormal_myocardial_fiber0.98715517
105MP0002084_abnormal_developmental_patter0.98115167
106MP0004185_abnormal_adipocyte_glucose0.96481175
107MP0003635_abnormal_synaptic_transmissio0.96132920
108MP0000015_abnormal_ear_pigmentation0.95900427
109MP0001851_eye_inflammation0.94236178
110MP0008058_abnormal_DNA_repair0.94052380
111MP0000383_abnormal_hair_follicle0.93915737
112MP0008775_abnormal_heart_ventricle0.92771309
113MP0002019_abnormal_tumor_incidence0.90842172
114MP0001324_abnormal_eye_pigmentation0.90219283
115MP0002734_abnormal_mechanical_nocicepti0.89763413
116MP0000230_abnormal_systemic_arterial0.88632238
117MP0005380_embryogenesis_phenotype0.88260493
118MP0001672_abnormal_embryogenesis/_devel0.88260493
119MP0008260_abnormal_autophagy0.88072267
120MP0000026_abnormal_inner_ear0.87027592
121MP0002752_abnormal_somatic_nervous0.86212776
122MP0003137_abnormal_impulse_conducting0.86177528
123MP0008057_abnormal_DNA_replication0.84971819
124MP0000490_abnormal_crypts_of0.84362321
125MP0000778_abnormal_nervous_system0.83969164
126MP0002163_abnormal_gland_morphology0.83046733
127MP0003878_abnormal_ear_physiology0.81629412
128MP0005377_hearing/vestibular/ear_phenot0.81629412
129MP0002822_catalepsy0.79916930
130MP0008789_abnormal_olfactory_epithelium0.79732278
131MP0001963_abnormal_hearing_physiology0.79200986
132MP0002751_abnormal_autonomic_nervous0.78963739
133MP0002277_abnormal_respiratory_mucosa0.78570452
134MP0009250_abnormal_appendicular_skeleto0.78349735
135MP0003755_abnormal_palate_morphology0.78331878
136MP0005085_abnormal_gallbladder_physiolo0.76419406
137MP0005187_abnormal_penis_morphology0.75820595
138MP0004782_abnormal_surfactant_physiolog0.75237050
139MP0001346_abnormal_lacrimal_gland0.74515146
140MP0005621_abnormal_cell_physiology0.74069015
141MP0005423_abnormal_somatic_nervous0.73683432
142MP0001873_stomach_inflammation0.73003860
143MP0004145_abnormal_muscle_electrophysio0.70921889
144MP0001919_abnormal_reproductive_system0.70769660
145MP0000427_abnormal_hair_cycle0.69268024
146MP0005647_abnormal_sex_gland0.68797141
147MP0005389_reproductive_system_phenotype0.67315484
148MP0009697_abnormal_copulation0.66857480
149MP0002177_abnormal_outer_ear0.64361638
150MP0000538_abnormal_urinary_bladder0.60266177
151MP0004510_myositis0.60003672
152MP0002168_other_aberrant_phenotype0.58336122
153MP0009384_cardiac_valve_regurgitation0.57353545
154MP0010234_abnormal_vibrissa_follicle0.56987432
155MP0003453_abnormal_keratinocyte_physiol0.56920294
156MP0002116_abnormal_craniofacial_bone0.56120616
157MP0003984_embryonic_growth_retardation0.54972142
158MP0004270_analgesia0.54866127
159MP0005384_cellular_phenotype0.54348025
160MP0003632_abnormal_nervous_system0.54054718
161MP0000613_abnormal_salivary_gland0.52485791
162MP0003329_amyloid_beta_deposits0.52231853
163MP0010307_abnormal_tumor_latency0.51888923
164MP0002109_abnormal_limb_morphology0.51422860
165MP0000678_abnormal_parathyroid_gland0.51210888
166MP0000631_abnormal_neuroendocrine_gland0.50884296
167MP0003890_abnormal_embryonic-extraembry0.50798105
168MP0002295_abnormal_pulmonary_circulatio0.50659366
169MP0002080_prenatal_lethality0.50582171
170MP0002088_abnormal_embryonic_growth/wei0.49948030
171MP0003763_abnormal_thymus_physiology0.49189795
172MP0003861_abnormal_nervous_system0.48795576
173MP0000432_abnormal_head_morphology0.48422287
174MP0000566_synostosis0.46589311
175MP0000767_abnormal_smooth_muscle0.45894259
176MP0002086_abnormal_extraembryonic_tissu0.45284976
177MP0002233_abnormal_nose_morphology0.44490166
178MP0000313_abnormal_cell_death0.41301823

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.98634239
2Papillary thyroid carcinoma (HP:0002895)5.85896658
3Birth length less than 3rd percentile (HP:0003561)4.65776102
4Chromsome breakage (HP:0040012)4.60116688
5Facial hemangioma (HP:0000329)4.48574742
6Breast hypoplasia (HP:0003187)4.18568117
7Flat capital femoral epiphysis (HP:0003370)4.14035986
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.13820420
9Patellar aplasia (HP:0006443)4.11907449
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.10281490
11Shawl scrotum (HP:0000049)4.07987454
12Abnormality of the labia minora (HP:0012880)4.01482686
13Cortical dysplasia (HP:0002539)4.00505166
14True hermaphroditism (HP:0010459)3.94321002
15Adrenal hypoplasia (HP:0000835)3.90430332
16Congenital stationary night blindness (HP:0007642)3.84745959
17Infertility (HP:0000789)3.78407441
18Nephronophthisis (HP:0000090)3.77783491
19Aplasia/Hypoplasia of the patella (HP:0006498)3.77191795
20Premature ovarian failure (HP:0008209)3.77155492
21Capillary hemangiomas (HP:0005306)3.67972651
22Type II lissencephaly (HP:0007260)3.56929469
23Secondary amenorrhea (HP:0000869)3.45109353
24Abnormality of the fingertips (HP:0001211)3.41121284
25Arterial tortuosity (HP:0005116)3.31315340
26Acute myeloid leukemia (HP:0004808)3.30543484
27Attenuation of retinal blood vessels (HP:0007843)3.30142108
28Abnormality of the renal medulla (HP:0100957)3.26689720
29Abnormality of the renal cortex (HP:0011035)3.23895009
30Thyroid carcinoma (HP:0002890)3.22458196
31Breast aplasia (HP:0100783)3.18456658
32Aplasia/Hypoplasia of the breasts (HP:0010311)3.16893031
33Medial flaring of the eyebrow (HP:0010747)3.14062104
34Abnormality of lateral ventricle (HP:0030047)3.13210647
35Hyperventilation (HP:0002883)2.98614077
36Abnormality of chromosome segregation (HP:0002916)2.93614282
37Spondylolisthesis (HP:0003302)2.91658383
38Vascular tortuosity (HP:0004948)2.89579436
39Insulin-resistant diabetes mellitus (HP:0000831)2.88513204
40Abnormality of chromosome stability (HP:0003220)2.80958280
41Oligodactyly (hands) (HP:0001180)2.79151836
42Tubular atrophy (HP:0000092)2.75652529
43Chronic bronchitis (HP:0004469)2.75506469
44Abolished electroretinogram (ERG) (HP:0000550)2.71038220
45Hypergonadotropic hypogonadism (HP:0000815)2.68813246
46Pulmonary fibrosis (HP:0002206)2.67367785
47Supernumerary spleens (HP:0009799)2.67261199
48Cystic liver disease (HP:0006706)2.63668259
49Abnormal rod and cone electroretinograms (HP:0008323)2.61220326
50Sandal gap (HP:0001852)2.60986728
51Concave nail (HP:0001598)2.58798780
52Acute necrotizing encephalopathy (HP:0006965)2.54557643
53Absent/shortened dynein arms (HP:0200106)2.54486019
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.54486019
55Decreased electroretinogram (ERG) amplitude (HP:0000654)2.53610897
56Abnormal drinking behavior (HP:0030082)2.53523170
57Polydipsia (HP:0001959)2.53523170
58Oligodactyly (HP:0012165)2.53447005
59Pendular nystagmus (HP:0012043)2.52574342
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.52249436
61Gait imbalance (HP:0002141)2.49790396
62Inability to walk (HP:0002540)2.49350850
63Lip pit (HP:0100267)2.45449487
64Abnormal respiratory motile cilium morphology (HP:0005938)2.45197285
65Abnormal respiratory epithelium morphology (HP:0012253)2.45197285
66Hypoplasia of the fovea (HP:0007750)2.44842903
67Aplasia/Hypoplasia of the fovea (HP:0008060)2.44842903
68Cerebellar dysplasia (HP:0007033)2.42211476
69Abnormality of the epiphysis of the femoral head (HP:0010574)2.40975999
70Abnormality of the phalanges of the hallux (HP:0010057)2.40675947
71Abnormality of the preputium (HP:0100587)2.40173055
72Overlapping toe (HP:0001845)2.39920484
73Abnormality of the fovea (HP:0000493)2.39712677
74Chronic hepatic failure (HP:0100626)2.39520575
75Primary amenorrhea (HP:0000786)2.39216714
76Congenital primary aphakia (HP:0007707)2.38324115
77Nonprogressive disorder (HP:0003680)2.38264769
78Pancreatic fibrosis (HP:0100732)2.37999054
79Renal cortical cysts (HP:0000803)2.37391965
80Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37118755
81Abnormality of macular pigmentation (HP:0008002)2.36710243
82Aplasia/Hypoplasia of the sternum (HP:0006714)2.36354504
83Prostate neoplasm (HP:0100787)2.34413413
84Mitochondrial inheritance (HP:0001427)2.34363248
85Acute encephalopathy (HP:0006846)2.31546380
86Sclerocornea (HP:0000647)2.30678565
87Congenital, generalized hypertrichosis (HP:0004540)2.30550382
88Wrist flexion contracture (HP:0001239)2.30062423
89Abnormality of the femoral head (HP:0003368)2.28968995
90Cystic hygroma (HP:0000476)2.28402237
91Volvulus (HP:0002580)2.28382058
92Meckel diverticulum (HP:0002245)2.27670013
93Progressive macrocephaly (HP:0004481)2.26949674
94Lissencephaly (HP:0001339)2.25660592
95Anterior segment dysgenesis (HP:0007700)2.25298377
96Increased CSF lactate (HP:0002490)2.24800962
97Increased corneal curvature (HP:0100692)2.22317911
98Keratoconus (HP:0000563)2.22317911
99Type 2 muscle fiber atrophy (HP:0003554)2.20716396
100Abnormal gallbladder physiology (HP:0012438)2.19602386
101Cholecystitis (HP:0001082)2.19602386
102Optic disc pallor (HP:0000543)2.18451142
103Broad-based gait (HP:0002136)2.16917562
104Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.16891287
105Abnormality of femoral epiphyses (HP:0006499)2.16891287
106Abnormal mitochondria in muscle tissue (HP:0008316)2.16427958
107Anencephaly (HP:0002323)2.15768776
108Congenital hepatic fibrosis (HP:0002612)2.15729419
109Constricted visual fields (HP:0001133)2.15617988
110Nephrogenic diabetes insipidus (HP:0009806)2.15219247
111Abnormality of the ileum (HP:0001549)2.11482025
112Decreased central vision (HP:0007663)2.10951381
113Muscle fiber atrophy (HP:0100295)2.10500947
114Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10029843
115Abnormality of alanine metabolism (HP:0010916)2.10029843
116Hyperalaninemia (HP:0003348)2.10029843
117Hyperglycemia (HP:0003074)2.09919145
118Male pseudohermaphroditism (HP:0000037)2.09454554
119Large for gestational age (HP:0001520)2.08159902
120Microglossia (HP:0000171)2.07900581
121Myelodysplasia (HP:0002863)2.07485308
122Sloping forehead (HP:0000340)2.06795334
123Febrile seizures (HP:0002373)2.06685467
124Clubbing of toes (HP:0100760)2.04878611
125Midline defect of the nose (HP:0004122)2.04647901
126Hypoplastic iliac wings (HP:0002866)2.04491056
127Small intestinal stenosis (HP:0012848)2.04390051
128Duodenal stenosis (HP:0100867)2.04390051
129Polyuria (HP:0000103)2.04194517
130Aplasia/Hypoplasia of the tibia (HP:0005772)2.03716841
131Furrowed tongue (HP:0000221)2.03701215
132Progressive inability to walk (HP:0002505)2.03230139
133Carpal bone hypoplasia (HP:0001498)2.03193999
134Hepatocellular necrosis (HP:0001404)2.02085169
135Postaxial foot polydactyly (HP:0001830)2.01795382
136Abnormal respiratory motile cilium physiology (HP:0012261)1.99932988
137Abnormal ciliary motility (HP:0012262)1.99028698
138Ectopic kidney (HP:0000086)1.98061283
139Genital tract atresia (HP:0001827)1.96507733
140Absent radius (HP:0003974)1.95732639
141Progressive cerebellar ataxia (HP:0002073)1.94153938
142Hepatic necrosis (HP:0002605)1.93823379
143Hypothermia (HP:0002045)1.92271461
1443-Methylglutaconic aciduria (HP:0003535)1.92136478
145Hyperglycinemia (HP:0002154)1.91679273
146Vaginal atresia (HP:0000148)1.89953011
147Gaze-evoked nystagmus (HP:0000640)1.88987706
148Chorioretinal atrophy (HP:0000533)1.87638981
149Pancreatic cysts (HP:0001737)1.87590398
150Abnormal biliary tract physiology (HP:0012439)1.86890640
151Bile duct proliferation (HP:0001408)1.86890640
152Fetal akinesia sequence (HP:0001989)1.86571434
153Fair hair (HP:0002286)1.86132906
154Focal motor seizures (HP:0011153)1.85955648
155Sparse lateral eyebrow (HP:0005338)1.85775964
156Absent forearm bone (HP:0003953)1.85565145
157Aplasia involving forearm bones (HP:0009822)1.85565145
158Abnormal spermatogenesis (HP:0008669)1.84836912
159Severe muscular hypotonia (HP:0006829)1.84565536
160Progressive microcephaly (HP:0000253)1.84125476
161Aplastic anemia (HP:0001915)1.83961220
162Clumsiness (HP:0002312)1.83753707
163Abnormality of midbrain morphology (HP:0002418)1.81889072
164Molar tooth sign on MRI (HP:0002419)1.81889072
165Widely spaced teeth (HP:0000687)1.80897245
166Bony spicule pigmentary retinopathy (HP:0007737)1.80643491
167Short thumb (HP:0009778)1.80211541
168Nephroblastoma (Wilms tumor) (HP:0002667)1.79897158
169Abnormality of the proximal phalanges of the hand (HP:0009834)1.79657814
170Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79389115
171Camptodactyly of toe (HP:0001836)1.78384715
172Hyperglycinuria (HP:0003108)1.78259516
173Small hand (HP:0200055)1.78154795
174Irregular epiphyses (HP:0010582)1.77666182
175Protruding tongue (HP:0010808)1.77157887
176Pachygyria (HP:0001302)1.77152729
177Retinal dysplasia (HP:0007973)1.76928735
178Astigmatism (HP:0000483)1.76788207
179Aplasia/Hypoplasia involving the musculature (HP:0001460)1.75527677
180Rib fusion (HP:0000902)1.74782384
181Genetic anticipation (HP:0003743)1.74415223
182Postaxial hand polydactyly (HP:0001162)1.74262466
183Azoospermia (HP:0000027)1.74208179
184Spontaneous abortion (HP:0005268)1.73670745
185Cafe-au-lait spot (HP:0000957)1.73508459
186Enlarged penis (HP:0000040)1.70860339
187Embryonal renal neoplasm (HP:0011794)1.70169411
188Lipid accumulation in hepatocytes (HP:0006561)1.70155017
189Hemiparesis (HP:0001269)1.69878172
190Aplasia/Hypoplasia of the tongue (HP:0010295)1.69587230

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.67168935
2MAP3K64.46349760
3LATS13.98867370
4LATS23.83154383
5ERBB43.49921764
6PLK43.45547372
7MUSK3.41709134
8KSR23.28649521
9TAOK33.10458873
10EEF2K3.09336575
11STK38L2.97718400
12ADRBK22.93737751
13ZAK2.85330866
14BRAF2.84504631
15TTK2.80358962
16MAP3K92.73669865
17WNK42.66230397
18MAP3K132.49796279
19MAP4K22.46566150
20INSRR2.41920371
21GRK12.37839622
22RAF12.36575027
23CDC72.35589071
24TLK12.25965611
25TAOK12.18965905
26MOS2.09788360
27ARAF2.09112584
28WNK32.07910253
29MAPKAPK32.04123353
30CASK1.99276670
31STK31.86988310
32CDK81.76455447
33PRKD31.63085552
34TXK1.59873454
35CAMKK21.59181932
36KIT1.59104503
37TNIK1.55997881
38MELK1.55460355
39CHEK21.43040820
40CDK91.41133387
41MAPKAPK51.40039270
42OXSR11.39531950
43DAPK21.38455064
44OBSCN1.35798712
45NEK21.34268495
46KSR11.33450318
47MARK11.27253941
48PAK61.27179963
49MAPK131.24728586
50DYRK21.24625427
51BCKDK1.23968404
52MAP3K41.22995054
53STK391.22990794
54PLK11.21670598
55TGFBR11.20852923
56STK101.18913107
57MKNK21.17433605
58MAPK151.17246103
59DMPK1.16966726
60BMPR21.15857972
61PNCK1.14854884
62ADRBK11.07888378
63PAK31.01498429
64PHKG21.01474426
65PHKG11.01474426
66TRIM281.00588185
67TRPM70.95975588
68MAP2K70.95877886
69MAP3K80.94000044
70TIE10.90090726
71MAP2K60.89154540
72NUAK10.88989099
73TEC0.88898351
74PRKCE0.87581461
75PTK2B0.87527984
76PRKCG0.86954591
77ABL20.86634694
78CAMK10.86223285
79TYRO30.85463231
80IKBKB0.85048132
81CCNB10.84953929
82RPS6KA50.84783590
83STK240.82582230
84STK380.82542337
85PRKD20.81331479
86PRKCQ0.76630583
87PRKAA20.74614369
88AURKB0.71701697
89VRK20.70939760
90ACVR1B0.67443068
91PLK30.65531680
92PKN10.65191337
93EPHA30.63805677
94RPS6KB20.62508704
95WEE10.62060311
96RET0.62008362
97AURKA0.61596454
98MAP2K40.61278138
99MKNK10.60708170
100BUB10.59202377
101PRKAA10.58213900
102MARK20.57217363
103CAMK1D0.56541650
104PIK3CG0.55913487
105CSNK1G10.55653434
106SYK0.55317981
107MAP3K50.54337610
108PRKACA0.53583316
109CDK30.52675487
110PIK3CA0.52447179
111NME10.52367748
112NEK90.51992089
113NLK0.49837588
114SIK20.49796125
115BMPR1B0.49674280
116NTRK20.49280004
117CHEK10.48084799
118ATM0.48004441
119CAMK40.46978155
120VRK10.46900699
121PDK20.46782970
122CSNK1D0.46585795
123IRAK10.45801218
124CSNK1A10.45676291
125CSNK1G20.45670240
126CAMKK10.45172947
127JAK30.45060133
128MAP3K10.44989651
129WNK10.44820734
130SGK20.43393956
131BRSK10.41651321
132MAPK110.41152911
133CDK190.38732544
134FGFR20.37953015
135MARK30.37693108
136CSNK1G30.37582947
137BRSK20.36452910
138PRKG10.35360356
139PRKCI0.33478194
140PRKCZ0.32688030
141SRPK10.32606462
142ABL10.32526443
143STK110.32288861
144FLT30.31807107
145PRKCA0.31529548
146DYRK30.31190646
147CAMK1G0.31085397
148NTRK30.30986913
149BCR0.30967124
150CAMK2A0.30889179
151SGK2230.27891212
152SGK4940.27891212
153PLK20.27499842
154CDK10.27496835
155PINK10.25877682
156CDK20.23477607
157CDK40.23176461
158HIPK20.21774679
159CDK70.21347433
160CHUK0.19642461
161MAP2K10.19536800
162CSNK1A1L0.18800944
163EIF2AK10.18292950
164JAK20.17657602
165ATR0.16459057
166MAP3K120.14955502
167CDK150.14045474
168MAPK100.14043834
169PAK10.13551178
170CDK180.12312732
171AKT10.11933575

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041104.63764373
2RNA degradation_Homo sapiens_hsa030183.82316459
3Basal transcription factors_Homo sapiens_hsa030223.58121310
4Ovarian steroidogenesis_Homo sapiens_hsa049133.41199016
5Phototransduction_Homo sapiens_hsa047442.96149499
6Vitamin B6 metabolism_Homo sapiens_hsa007502.93792505
7Oxidative phosphorylation_Homo sapiens_hsa001902.90333354
8Circadian rhythm_Homo sapiens_hsa047102.86117056
9Homologous recombination_Homo sapiens_hsa034402.54992848
10Pancreatic cancer_Homo sapiens_hsa052122.44614612
11Oocyte meiosis_Homo sapiens_hsa041142.44037244
12Parkinsons disease_Homo sapiens_hsa050122.37742278
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.34164067
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29095119
15Fanconi anemia pathway_Homo sapiens_hsa034602.28133785
16Butanoate metabolism_Homo sapiens_hsa006502.27687987
17Selenocompound metabolism_Homo sapiens_hsa004502.23245377
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23210050
19Nitrogen metabolism_Homo sapiens_hsa009102.20196799
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16354200
21Linoleic acid metabolism_Homo sapiens_hsa005912.15213353
22Maturity onset diabetes of the young_Homo sapiens_hsa049502.12552591
23TGF-beta signaling pathway_Homo sapiens_hsa043502.08226218
24Ether lipid metabolism_Homo sapiens_hsa005652.03893369
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03819606
26p53 signaling pathway_Homo sapiens_hsa041151.99860116
27Nicotine addiction_Homo sapiens_hsa050331.97942429
28Dorso-ventral axis formation_Homo sapiens_hsa043201.82547673
29RNA polymerase_Homo sapiens_hsa030201.74722274
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74634749
31RNA transport_Homo sapiens_hsa030131.70450671
32Tryptophan metabolism_Homo sapiens_hsa003801.70025221
33Olfactory transduction_Homo sapiens_hsa047401.66857316
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65275934
35Base excision repair_Homo sapiens_hsa034101.61163727
36GnRH signaling pathway_Homo sapiens_hsa049121.58881429
37Prolactin signaling pathway_Homo sapiens_hsa049171.57232233
38Huntingtons disease_Homo sapiens_hsa050161.55498793
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.52646029
40Colorectal cancer_Homo sapiens_hsa052101.52049667
41Non-homologous end-joining_Homo sapiens_hsa034501.48150827
42Protein export_Homo sapiens_hsa030601.46697842
43Propanoate metabolism_Homo sapiens_hsa006401.46163643
44Alzheimers disease_Homo sapiens_hsa050101.44750720
45Taste transduction_Homo sapiens_hsa047421.43010593
46Choline metabolism in cancer_Homo sapiens_hsa052311.40351557
47Caffeine metabolism_Homo sapiens_hsa002321.39867408
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39745155
49MicroRNAs in cancer_Homo sapiens_hsa052061.36418723
50Peroxisome_Homo sapiens_hsa041461.35898076
51Cardiac muscle contraction_Homo sapiens_hsa042601.33333111
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31902032
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.31074497
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31070646
55Mismatch repair_Homo sapiens_hsa034301.29282913
56Ribosome_Homo sapiens_hsa030101.28109933
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20990319
58DNA replication_Homo sapiens_hsa030301.20478248
59Morphine addiction_Homo sapiens_hsa050321.19879387
60Asthma_Homo sapiens_hsa053101.19826772
61ABC transporters_Homo sapiens_hsa020101.17191556
62Other glycan degradation_Homo sapiens_hsa005111.17032262
63Nucleotide excision repair_Homo sapiens_hsa034201.13333677
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09849831
65Renal cell carcinoma_Homo sapiens_hsa052111.08392963
66Steroid hormone biosynthesis_Homo sapiens_hsa001401.04907948
67Thyroid cancer_Homo sapiens_hsa052161.03375666
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01487987
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00759373
70One carbon pool by folate_Homo sapiens_hsa006700.99403719
71GABAergic synapse_Homo sapiens_hsa047270.97604750
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97024432
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.96955166
74VEGF signaling pathway_Homo sapiens_hsa043700.96019418
75mRNA surveillance pathway_Homo sapiens_hsa030150.93411628
76Chemical carcinogenesis_Homo sapiens_hsa052040.92861611
77Circadian entrainment_Homo sapiens_hsa047130.92081754
78FoxO signaling pathway_Homo sapiens_hsa040680.90811158
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90773407
80Regulation of autophagy_Homo sapiens_hsa041400.90249407
81Endometrial cancer_Homo sapiens_hsa052130.88266882
82beta-Alanine metabolism_Homo sapiens_hsa004100.86021590
83Long-term depression_Homo sapiens_hsa047300.84590246
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84313699
85Hepatitis B_Homo sapiens_hsa051610.83570473
86Primary immunodeficiency_Homo sapiens_hsa053400.83254127
87Adherens junction_Homo sapiens_hsa045200.83011233
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.82910553
89Insulin secretion_Homo sapiens_hsa049110.82284592
90Retinol metabolism_Homo sapiens_hsa008300.82239660
91Hippo signaling pathway_Homo sapiens_hsa043900.81037655
92Calcium signaling pathway_Homo sapiens_hsa040200.80449079
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74959059
94Ras signaling pathway_Homo sapiens_hsa040140.74397718
95Salivary secretion_Homo sapiens_hsa049700.72749601
96Graft-versus-host disease_Homo sapiens_hsa053320.71234186
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70528712
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68050118
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.66728875
100Chronic myeloid leukemia_Homo sapiens_hsa052200.66329330
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66157024
102Small cell lung cancer_Homo sapiens_hsa052220.66104170
103Metabolic pathways_Homo sapiens_hsa011000.66036607
104Non-small cell lung cancer_Homo sapiens_hsa052230.65483174
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64492534
106Purine metabolism_Homo sapiens_hsa002300.63999228
107mTOR signaling pathway_Homo sapiens_hsa041500.63890399
108Type I diabetes mellitus_Homo sapiens_hsa049400.63680478
109Sulfur metabolism_Homo sapiens_hsa009200.63614395
110Allograft rejection_Homo sapiens_hsa053300.63386193
111Autoimmune thyroid disease_Homo sapiens_hsa053200.63216086
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62488661
113Prostate cancer_Homo sapiens_hsa052150.61479155
114Proteasome_Homo sapiens_hsa030500.61011795
115Fat digestion and absorption_Homo sapiens_hsa049750.60914475
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60641947
117Histidine metabolism_Homo sapiens_hsa003400.60476392
118Pyrimidine metabolism_Homo sapiens_hsa002400.60264352
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59771277
120Herpes simplex infection_Homo sapiens_hsa051680.59336134
121Sphingolipid metabolism_Homo sapiens_hsa006000.59147105
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58599036
123Glycerolipid metabolism_Homo sapiens_hsa005610.58573207
124Collecting duct acid secretion_Homo sapiens_hsa049660.58407673
125HTLV-I infection_Homo sapiens_hsa051660.57468140
126Estrogen signaling pathway_Homo sapiens_hsa049150.57063621
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56849166
128Sulfur relay system_Homo sapiens_hsa041220.55740401
129Arachidonic acid metabolism_Homo sapiens_hsa005900.55531471
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55170911
131Bladder cancer_Homo sapiens_hsa052190.54779163
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53910803
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53656096
134MAPK signaling pathway_Homo sapiens_hsa040100.51627353
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50037542
136ErbB signaling pathway_Homo sapiens_hsa040120.49433059
137Serotonergic synapse_Homo sapiens_hsa047260.49145010
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48896295
139TNF signaling pathway_Homo sapiens_hsa046680.47758271
140Shigellosis_Homo sapiens_hsa051310.46387516
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45437894
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45271170
143Dopaminergic synapse_Homo sapiens_hsa047280.44937335
144Inositol phosphate metabolism_Homo sapiens_hsa005620.43172647
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42511681
146Mineral absorption_Homo sapiens_hsa049780.41994545
147Vitamin digestion and absorption_Homo sapiens_hsa049770.41985807
148Notch signaling pathway_Homo sapiens_hsa043300.41254746
149Systemic lupus erythematosus_Homo sapiens_hsa053220.40003957
150Rheumatoid arthritis_Homo sapiens_hsa053230.38847721
151Fatty acid degradation_Homo sapiens_hsa000710.36514094
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.34786124
153Amphetamine addiction_Homo sapiens_hsa050310.34776538
154cAMP signaling pathway_Homo sapiens_hsa040240.34046566
155Cocaine addiction_Homo sapiens_hsa050300.33057608
156Alcoholism_Homo sapiens_hsa050340.32981658
157Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32285564
158Epstein-Barr virus infection_Homo sapiens_hsa051690.31801934
159Jak-STAT signaling pathway_Homo sapiens_hsa046300.31485033
160Glioma_Homo sapiens_hsa052140.31133550
161Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29592679
162Glutamatergic synapse_Homo sapiens_hsa047240.29497278
163Vascular smooth muscle contraction_Homo sapiens_hsa042700.28932856
164Melanoma_Homo sapiens_hsa052180.28701856
165Viral carcinogenesis_Homo sapiens_hsa052030.28308720
166Pathways in cancer_Homo sapiens_hsa052000.27675999
167NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23066903
168Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22751544
169Wnt signaling pathway_Homo sapiens_hsa043100.22251850
170Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21111292
171Influenza A_Homo sapiens_hsa051640.20278826
172AMPK signaling pathway_Homo sapiens_hsa041520.19339579
173Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16948786
174Toxoplasmosis_Homo sapiens_hsa051450.15882081
175Arginine and proline metabolism_Homo sapiens_hsa003300.15830638
176Oxytocin signaling pathway_Homo sapiens_hsa049210.12820893
177Lysine degradation_Homo sapiens_hsa003100.12474381

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