PKD1P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.52456334
2neural tube development (GO:0021915)4.01162955
3semaphorin-plexin signaling pathway (GO:0071526)3.98168228
4planar cell polarity pathway involved in neural tube closure (GO:0090179)3.92582354
5mannose metabolic process (GO:0006013)3.91956965
6negative regulation of cell size (GO:0045792)3.66668738
7lung epithelium development (GO:0060428)3.66551728
8regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.62189904
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.61081888
10synaptic vesicle docking involved in exocytosis (GO:0016081)3.53527279
11negative regulation of erythrocyte differentiation (GO:0045647)3.52830798
12regulation of histone H3-K27 methylation (GO:0061085)3.51704655
13cell migration in hindbrain (GO:0021535)3.50225648
14insulin-like growth factor receptor signaling pathway (GO:0048009)3.45763831
15regulation of ARF GTPase activity (GO:0032312)3.41675005
16adherens junction assembly (GO:0034333)3.41478103
17positive regulation of synapse maturation (GO:0090129)3.38538026
18cell-substrate adherens junction assembly (GO:0007045)3.20577296
19focal adhesion assembly (GO:0048041)3.20577296
20histone H3-K4 methylation (GO:0051568)3.17189388
21histone H3-K4 trimethylation (GO:0080182)3.15452115
22histone H3-K9 demethylation (GO:0033169)3.12373670
23collecting duct development (GO:0072044)3.11246913
24negative regulation of histone methylation (GO:0031061)3.07223217
25positive regulation of gene expression, epigenetic (GO:0045815)3.04885068
26positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.04754306
27positive regulation of CREB transcription factor activity (GO:0032793)3.02716552
28histone H4 deacetylation (GO:0070933)2.96836227
29stress granule assembly (GO:0034063)2.96138272
30cytoskeletal anchoring at plasma membrane (GO:0007016)2.95552656
31histone H3 deacetylation (GO:0070932)2.91468074
32regulation of NFAT protein import into nucleus (GO:0051532)2.91106051
33convergent extension (GO:0060026)2.89755217
34histone lysine methylation (GO:0034968)2.88185094
35glucocorticoid receptor signaling pathway (GO:0042921)2.83240515
36renal system development (GO:0072001)2.83136067
37cerebellar granule cell differentiation (GO:0021707)2.81463452
38chromatin silencing (GO:0006342)2.79625454
39nucleosome disassembly (GO:0006337)2.75254116
40protein-DNA complex disassembly (GO:0032986)2.75254116
41cell-substrate junction assembly (GO:0007044)2.74470601
42protein heterotrimerization (GO:0070208)2.74144187
43positive regulation of histone deacetylation (GO:0031065)2.72734448
44regulation of synapse maturation (GO:0090128)2.71155467
45regulation of RNA export from nucleus (GO:0046831)2.70077111
46peptidyl-lysine dimethylation (GO:0018027)2.69680083
47cell-cell junction maintenance (GO:0045217)2.68811846
48endothelial cell chemotaxis (GO:0035767)2.68062419
49negative regulation of fatty acid transport (GO:2000192)2.67149449
50histone H3-K36 demethylation (GO:0070544)2.66055409
51negative regulation of myotube differentiation (GO:0010832)2.65646813
52camera-type eye morphogenesis (GO:0048593)2.64018848
53regulation of ARF protein signal transduction (GO:0032012)2.63517115
54Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.57918668
55histone lysine demethylation (GO:0070076)2.56565231
56regulation of nucleobase-containing compound transport (GO:0032239)2.55832536
57mitotic G1 DNA damage checkpoint (GO:0031571)2.54917828
58histone H3-K9 methylation (GO:0051567)2.54414204
59cellular response to epidermal growth factor stimulus (GO:0071364)2.52120557
60histone H3-K9 modification (GO:0061647)2.51566948
61regulation of p38MAPK cascade (GO:1900744)2.51217415
62mitotic G1/S transition checkpoint (GO:0044819)2.49349887
63intracellular estrogen receptor signaling pathway (GO:0030520)2.49146171
64G1 DNA damage checkpoint (GO:0044783)2.47878718
65apoptotic process involved in morphogenesis (GO:0060561)2.47383965
66establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.47201098
67mitochondrion transport along microtubule (GO:0047497)2.47201098
68embryonic retina morphogenesis in camera-type eye (GO:0060059)2.47033751
69histone demethylation (GO:0016577)2.45891824
70regulation of establishment of planar polarity (GO:0090175)2.44599414
71histone methylation (GO:0016571)2.44296538
72response to epidermal growth factor (GO:0070849)2.41447968
73negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.38373431
74negative regulation of translation, ncRNA-mediated (GO:0040033)2.38373431
75regulation of translation, ncRNA-mediated (GO:0045974)2.38373431
76regulation of fatty acid beta-oxidation (GO:0031998)2.37604474
77negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.36824415
78neuronal ion channel clustering (GO:0045161)2.36342707
79regulation of histone H3-K4 methylation (GO:0051569)2.35585796
80positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.34865874
81metanephric tubule development (GO:0072170)2.34763206
82metanephric nephron tubule development (GO:0072234)2.34763206
83atrioventricular valve morphogenesis (GO:0003181)2.34724607
84positive regulation of protein kinase C signaling (GO:0090037)2.33275488
85establishment of apical/basal cell polarity (GO:0035089)2.32287339
86positive regulation of dendrite morphogenesis (GO:0050775)2.30910821
87regulation of mitotic spindle organization (GO:0060236)2.29672021
88spinal cord development (GO:0021510)2.29158944
89positive regulation of blood vessel endothelial cell migration (GO:0043536)2.28427294
90activation of JUN kinase activity (GO:0007257)2.27220095
91regulation of histone methylation (GO:0031060)2.26696955
92regulation of axon extension involved in axon guidance (GO:0048841)2.25625709
93coronary vasculature morphogenesis (GO:0060977)2.24588523
94osteoblast development (GO:0002076)2.24343629
95establishment of mitochondrion localization (GO:0051654)2.24308520
96cell volume homeostasis (GO:0006884)2.23834767
97histone deacetylation (GO:0016575)2.23621543
98cardiac myofibril assembly (GO:0055003)2.22762559
99cerebellar Purkinje cell differentiation (GO:0021702)2.21167405
100negative regulation of gene expression, epigenetic (GO:0045814)2.20075299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.84729625
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.90687172
3KDM2B_26808549_Chip-Seq_SUP-B15_Human2.90395259
4MYC_22102868_ChIP-Seq_BL_Human2.80820476
5KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.70311230
6KDM2B_26808549_Chip-Seq_K562_Human2.69509299
7LXR_22292898_ChIP-Seq_THP-1_Human2.69083281
8DROSHA_22980978_ChIP-Seq_HELA_Human2.68325689
9KDM2B_26808549_Chip-Seq_DND41_Human2.53415654
10TCF7_22412390_ChIP-Seq_EML_Mouse2.42857231
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30794997
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.22296379
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.21356045
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.20871794
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.19866847
16EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.17056716
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.13351517
18VDR_21846776_ChIP-Seq_THP-1_Human2.11297781
19ZFP281_27345836_Chip-Seq_ESCs_Mouse2.09945918
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.08834199
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.03022045
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.96584721
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95447964
24KDM2B_26808549_Chip-Seq_JURKAT_Human1.95123094
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86023507
26RACK7_27058665_Chip-Seq_MCF-7_Human1.84446534
27SMC4_20622854_ChIP-Seq_HELA_Human1.84417783
28P68_20966046_ChIP-Seq_HELA_Human1.82296722
29CREB1_26743006_Chip-Seq_LNCaP_Human1.78640835
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74484503
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.74080282
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74017118
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73605734
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70247978
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.65982230
36CTCF_27219007_Chip-Seq_Bcells_Human1.63785630
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61702128
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.61142923
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58194710
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.57130900
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.56324103
42GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53215372
43UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52830057
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49570316
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48001314
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.44373854
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.43844494
48E2F7_22180533_ChIP-Seq_HELA_Human1.43537119
49EZH2_22144423_ChIP-Seq_EOC_Human1.42108940
50CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.41541021
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40004910
52TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.38108120
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36813664
54TP53_22127205_ChIP-Seq_IMR90_Human1.36170360
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33865420
56NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33664324
57MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.32203329
58NCOR1_26117541_ChIP-Seq_K562_Human1.32021674
59SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31356478
60TP53_23651856_ChIP-Seq_MEFs_Mouse1.29227144
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28294572
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.22677881
63TET1_21490601_ChIP-Seq_MESCs_Mouse1.22466525
64OCT4_19829295_ChIP-Seq_ESCs_Human1.20959361
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19419827
66ZNF263_19887448_ChIP-Seq_K562_Human1.18495816
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.15473360
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13763676
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13278202
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.11626009
71MAF_26560356_Chip-Seq_TH2_Human1.11376642
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11085233
73TP63_22573176_ChIP-Seq_HFKS_Human1.10321802
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09551699
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09551699
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09459066
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.08888525
78SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07307147
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06877227
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06634144
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06146438
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.05874110
83SCL_19346495_ChIP-Seq_HPC-7_Human1.03793811
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01864939
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.00253764
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00021701
87GATA1_19941826_ChIP-Seq_K562_Human0.98814081
88SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97894136
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97051495
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95533514
91UTX_26944678_Chip-Seq_JUKART_Human0.94323335
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92709938
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92062872
94MITF_21258399_ChIP-Seq_MELANOMA_Human0.91748611
95ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91090990
96SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.89564042
97PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89429399
98RARB_24833708_ChIP-Seq_LIVER_Mouse0.88829038
99POU5F1_16518401_ChIP-PET_MESCs_Mouse0.88401584
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88306652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.24042452
2MP0002249_abnormal_larynx_morphology3.22503293
3MP0008438_abnormal_cutaneous_collagen2.92848020
4MP0005076_abnormal_cell_differentiation2.91211463
5MP0000566_synostosis2.74869098
6MP0000751_myopathy2.69228652
7MP0004859_abnormal_synaptic_plasticity2.43158308
8MP0003279_aneurysm2.39835422
9MP0001849_ear_inflammation2.37344173
10MP0005503_abnormal_tendon_morphology2.26785475
11MP0009278_abnormal_bone_marrow2.24096309
12MP0005409_darkened_coat_color2.01340308
13MP0004858_abnormal_nervous_system1.95669588
14MP0005670_abnormal_white_adipose1.93571095
15MP0001348_abnormal_lacrimal_gland1.92028556
16MP0003172_abnormal_lysosome_physiology1.88250949
17MP0000678_abnormal_parathyroid_gland1.85711490
18MP0010030_abnormal_orbit_morphology1.78839481
19MP0005257_abnormal_intraocular_pressure1.77011331
20MP0002108_abnormal_muscle_morphology1.59120394
21MP0009384_cardiac_valve_regurgitation1.55721841
22MP0001299_abnormal_eye_distance/1.52623433
23MP0005275_abnormal_skin_tensile1.49793283
24MP0002089_abnormal_postnatal_growth/wei1.47030614
25MP0004272_abnormal_basement_membrane1.45399051
26MP0001958_emphysema1.45247944
27MP0003385_abnormal_body_wall1.44776601
28MP0000733_abnormal_muscle_development1.43871666
29MP0003115_abnormal_respiratory_system1.40968691
30MP0002822_catalepsy1.40888669
31MP0001502_abnormal_circadian_rhythm1.37965113
32MP0000003_abnormal_adipose_tissue1.36591652
33MP0000579_abnormal_nail_morphology1.36577584
34MP0002396_abnormal_hematopoietic_system1.34970836
35MP0009672_abnormal_birth_weight1.33707782
36MP0006138_congestive_heart_failure1.31706199
37MP0003045_fibrosis1.29966550
38MP0002116_abnormal_craniofacial_bone1.29539030
39MP0004145_abnormal_muscle_electrophysio1.26603460
40MP0003942_abnormal_urinary_system1.26591743
41MP0005666_abnormal_adipose_tissue1.25862952
42MP0004233_abnormal_muscle_weight1.25097576
43MP0005375_adipose_tissue_phenotype1.24378124
44MP0000759_abnormal_skeletal_muscle1.20369060
45MP0008995_early_reproductive_senescence1.19196576
46MP0000428_abnormal_craniofacial_morphol1.18794172
47MP0010630_abnormal_cardiac_muscle1.17194453
48MP0004087_abnormal_muscle_fiber1.16034654
49MP0000747_muscle_weakness1.13768989
50MP0000432_abnormal_head_morphology1.12703034
51MP0002932_abnormal_joint_morphology1.11829010
52MP0005171_absent_coat_pigmentation1.11076291
53MP0004130_abnormal_muscle_cell1.11062189
54MP0004185_abnormal_adipocyte_glucose1.09393488
55MP0005508_abnormal_skeleton_morphology1.09240149
56MP0002114_abnormal_axial_skeleton1.07363792
57MP0003566_abnormal_cell_adhesion1.06248183
58MP0003635_abnormal_synaptic_transmissio1.05334690
59MP0002925_abnormal_cardiovascular_devel1.05064142
60MP0003861_abnormal_nervous_system1.02816024
61MP0008569_lethality_at_weaning1.01017518
62MP0004084_abnormal_cardiac_muscle0.99416070
63MP0003091_abnormal_cell_migration0.96671805
64MP0002060_abnormal_skin_morphology0.95213693
65MP0003935_abnormal_craniofacial_develop0.94084945
66MP0004381_abnormal_hair_follicle0.93746967
67MP0000049_abnormal_middle_ear0.91059737
68MP0000013_abnormal_adipose_tissue0.91027108
69MP0004036_abnormal_muscle_relaxation0.90557929
70MP0004270_analgesia0.90462559
71MP0002063_abnormal_learning/memory/cond0.90291717
72MP0003283_abnormal_digestive_organ0.89868075
73MP0003123_paternal_imprinting0.89237746
74MP0000767_abnormal_smooth_muscle0.87321623
75MP0009703_decreased_birth_body0.87297327
76MP0002933_joint_inflammation0.86891678
77MP0004197_abnormal_fetal_growth/weight/0.86463683
78MP0000534_abnormal_ureter_morphology0.85661479
79MP0005369_muscle_phenotype0.85174607
80MP0000266_abnormal_heart_morphology0.84138692
81MP0010368_abnormal_lymphatic_system0.78945621
82MP0003948_abnormal_gas_homeostasis0.78917805
83MP0001270_distended_abdomen0.78890257
84MP0009780_abnormal_chondrocyte_physiolo0.77813151
85MP0006292_abnormal_olfactory_placode0.77530451
86MP0002106_abnormal_muscle_physiology0.76594303
87MP0002081_perinatal_lethality0.74649957
88MP0005499_abnormal_olfactory_system0.74461621
89MP0005394_taste/olfaction_phenotype0.74461621
90MP0008260_abnormal_autophagy0.74013255
91MP0000681_abnormal_thyroid_gland0.73972459
92MP0005423_abnormal_somatic_nervous0.72459800
93MP0008770_decreased_survivor_rate0.72096655
94MP0002970_abnormal_white_adipose0.71446821
95MP0005621_abnormal_cell_physiology0.71232230
96MP0001730_embryonic_growth_arrest0.71227167
97MP0002269_muscular_atrophy0.70646654
98MP0002184_abnormal_innervation0.70637342
99MP0003111_abnormal_nucleus_morphology0.70208925
100MP0005397_hematopoietic_system_phenotyp0.70101470

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.47148776
2Cerebral aneurysm (HP:0004944)3.90380250
3Shallow orbits (HP:0000586)3.57226560
4Hyperacusis (HP:0010780)3.53743046
5Broad face (HP:0000283)3.36663021
6Abnormality of the fingertips (HP:0001211)3.10777367
7Protrusio acetabuli (HP:0003179)3.04426963
8Turricephaly (HP:0000262)2.66712955
9Bronchomalacia (HP:0002780)2.61979061
10Long eyelashes (HP:0000527)2.59950610
11Ulnar bowing (HP:0003031)2.58608754
12Bowel diverticulosis (HP:0005222)2.53969835
13Genetic anticipation (HP:0003743)2.50231609
14Disproportionate tall stature (HP:0001519)2.49178949
15Thin ribs (HP:0000883)2.46710399
16Broad metatarsal (HP:0001783)2.41072769
17Premature rupture of membranes (HP:0001788)2.39798049
18Pointed chin (HP:0000307)2.38353947
19Aneurysm (HP:0002617)2.32385407
20Bladder diverticulum (HP:0000015)2.27004916
21Abnormality of the aortic arch (HP:0012303)2.25715019
22Trigonocephaly (HP:0000243)2.21209739
23Distal upper limb amyotrophy (HP:0007149)2.21206659
24Upper limb amyotrophy (HP:0009129)2.21206659
25Bell-shaped thorax (HP:0001591)2.18457068
26Distal lower limb amyotrophy (HP:0008944)2.16826970
27Renovascular hypertension (HP:0100817)2.16711313
28Biconcave vertebral bodies (HP:0004586)2.16664689
29Cervical subluxation (HP:0003308)2.15702280
30Urethral obstruction (HP:0000796)2.14418075
31Narrow palate (HP:0000189)2.11796677
32Insomnia (HP:0100785)2.08561194
33Stridor (HP:0010307)2.08466568
34Dysmetric saccades (HP:0000641)2.06349917
35Flat cornea (HP:0007720)2.05154330
36Lower limb amyotrophy (HP:0007210)2.03403208
37Bowel incontinence (HP:0002607)2.01831808
38Premature skin wrinkling (HP:0100678)2.01609390
39Atelectasis (HP:0100750)1.98562072
40Fragile skin (HP:0001030)1.98284419
41Precocious puberty (HP:0000826)1.97821403
42Mildly elevated creatine phosphokinase (HP:0008180)1.97748907
43Thin bony cortex (HP:0002753)1.97693888
44Aortic aneurysm (HP:0004942)1.97460052
45Type 1 muscle fiber predominance (HP:0003803)1.95774752
46Tracheomalacia (HP:0002779)1.95528544
47Lymphangioma (HP:0100764)1.94881269
48Mitral regurgitation (HP:0001653)1.94763802
49Mild short stature (HP:0003502)1.93785633
50Spinal rigidity (HP:0003306)1.93320190
51Abnormality of cochlea (HP:0000375)1.93024506
52Progressive cerebellar ataxia (HP:0002073)1.92774479
53Sleep apnea (HP:0010535)1.91102272
54Mitral valve prolapse (HP:0001634)1.90887566
55Broad thumb (HP:0011304)1.90648737
56Atrophic scars (HP:0001075)1.90037527
57Increased connective tissue (HP:0009025)1.89628181
58Laryngomalacia (HP:0001601)1.89466203
59Broad palm (HP:0001169)1.89215056
60Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88993427
61Heterotopia (HP:0002282)1.88082117
62Renal duplication (HP:0000075)1.87774079
63Broad phalanges of the hand (HP:0009768)1.86811366
64Aortic regurgitation (HP:0001659)1.86799583
65Dislocated radial head (HP:0003083)1.86774725
66Neoplasm of the heart (HP:0100544)1.86198745
67Round ear (HP:0100830)1.86093729
68Overriding aorta (HP:0002623)1.81275924
69Broad finger (HP:0001500)1.80261066
70Elfin facies (HP:0004428)1.79305791
71Shawl scrotum (HP:0000049)1.79259954
72Neonatal short-limb short stature (HP:0008921)1.78882779
73Genu recurvatum (HP:0002816)1.78846282
74Increased variability in muscle fiber diameter (HP:0003557)1.78649026
75Joint laxity (HP:0001388)1.77761659
76Hypoplastic ischia (HP:0003175)1.75535640
77Abnormality of the radial head (HP:0003995)1.75075250
78Annular pancreas (HP:0001734)1.74939421
79Natal tooth (HP:0000695)1.74775611
80Abnormal large intestine physiology (HP:0012700)1.74724611
81Patellar dislocation (HP:0002999)1.73966787
82Megalocornea (HP:0000485)1.73302031
83Vertebral arch anomaly (HP:0008438)1.72530996
84Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72087616
85Broad long bones (HP:0005622)1.71799548
86Advanced eruption of teeth (HP:0006288)1.70824562
87Abnormality of the columella (HP:0009929)1.70263718
88Broad phalanx (HP:0006009)1.69688652
89Aplasia involving bones of the upper limbs (HP:0009823)1.67922324
90Aplasia of the phalanges of the hand (HP:0009802)1.67922324
91Aplasia involving bones of the extremities (HP:0009825)1.67922324
92Morphological abnormality of the inner ear (HP:0011390)1.67175324
93Polycystic kidney dysplasia (HP:0000113)1.66338888
94Long palpebral fissure (HP:0000637)1.65734046
95Skull defect (HP:0001362)1.65278189
96Abnormality of the distal phalanx of the thumb (HP:0009617)1.64031766
97Narrow nasal bridge (HP:0000446)1.62801854
98Hand muscle atrophy (HP:0009130)1.62388545
99Arnold-Chiari malformation (HP:0002308)1.60315226
100Impaired smooth pursuit (HP:0007772)1.60302893

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.82642156
2EEF2K3.77925971
3CDK123.58541236
4ICK3.09061943
5SIK12.89976996
6PRPF4B2.38565263
7MAP3K102.34841625
8RIPK12.28998112
9SMG12.13933520
10SIK22.08623791
11TTN2.05127035
12FGFR42.05086145
13MARK22.02405352
14MAP3K71.93680234
15CAMK1D1.87099397
16PKN21.83003757
17MTOR1.80936866
18PDGFRA1.68759042
19CAMK1G1.68230136
20TYRO31.53339865
21FGFR21.51572306
22PRKD31.51063097
23CDC42BPA1.33963108
24MAP3K131.29805203
25KSR21.20610641
26RPS6KA21.19694165
27WNK11.18569691
28CAMKK11.14487722
29BMX1.13427824
30MAP3K61.13100513
31NTRK31.08852691
32BRD41.05071384
33DDR21.03063546
34INSRR0.98300440
35PRKCH0.96961070
36MAPK150.95778554
37PRKD20.94619229
38TNK20.94217162
39RPS6KL10.93840578
40RPS6KC10.93840578
41ERN10.90568400
42FGFR30.90409148
43NTRK10.89577220
44PAK60.88406278
45SGK30.87421514
46CAMK10.86124568
47SGK4940.83725619
48SGK2230.83725619
49PRKAA10.83163387
50AKT30.82054333
51HIPK20.81568134
52PTK20.80995542
53RPS6KA60.78069720
54MET0.77663808
55ERBB20.77637008
56RET0.75649620
57SGK20.75506617
58NTRK20.75119787
59PTK60.73442532
60CAMK40.72435856
61MARK10.72410017
62PDGFRB0.71303269
63MAPK110.70681189
64WNK40.68482153
65MAPK70.67848655
66MAPK100.66854790
67NME10.66714477
68PAK20.65078097
69MAP2K30.64257409
70MAPK80.64209906
71MAPK120.61225747
72PRKAA20.61182494
73CDK40.59608565
74STK380.58085959
75LATS10.58059790
76LATS20.56703882
77MAPK10.56294156
78GSK3B0.55597985
79NEK20.54064779
80PDPK10.52817512
81MAP2K60.52484712
82CDK20.50698970
83SGK10.46874587
84RPS6KA10.46200240
85MAPK30.45930278
86DMPK0.45881740
87DYRK1B0.45730427
88AKT10.45445392
89CDK10.42752249
90CHEK10.41886767
91TRPM70.41047499
92FGFR10.39918914
93CHUK0.39834167
94MST1R0.38796383
95PRKDC0.37896037
96UHMK10.37837707
97MAPK140.36626830
98KSR10.35713059
99RPS6KA30.35700745
100MUSK0.35483045

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.18986332
2Notch signaling pathway_Homo sapiens_hsa043302.11280086
3Chronic myeloid leukemia_Homo sapiens_hsa052201.66866171
4mTOR signaling pathway_Homo sapiens_hsa041501.62926681
5Thyroid hormone signaling pathway_Homo sapiens_hsa049191.60507191
6VEGF signaling pathway_Homo sapiens_hsa043701.58544941
7ECM-receptor interaction_Homo sapiens_hsa045121.53265838
8Phosphatidylinositol signaling system_Homo sapiens_hsa040701.50943647
9Acute myeloid leukemia_Homo sapiens_hsa052211.50391712
10Phospholipase D signaling pathway_Homo sapiens_hsa040721.49904717
11Glioma_Homo sapiens_hsa052141.48594571
12Longevity regulating pathway - mammal_Homo sapiens_hsa042111.47294113
13Non-small cell lung cancer_Homo sapiens_hsa052231.46119069
14ErbB signaling pathway_Homo sapiens_hsa040121.45432435
15Long-term potentiation_Homo sapiens_hsa047201.44023253
16Other glycan degradation_Homo sapiens_hsa005111.43033731
17Choline metabolism in cancer_Homo sapiens_hsa052311.42500761
18GnRH signaling pathway_Homo sapiens_hsa049121.42066845
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41878116
20Focal adhesion_Homo sapiens_hsa045101.37457369
21MicroRNAs in cancer_Homo sapiens_hsa052061.32882437
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29474973
23Endometrial cancer_Homo sapiens_hsa052131.28889960
24Insulin signaling pathway_Homo sapiens_hsa049101.24947824
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.23269904
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.23161361
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.22561325
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22386147
29Estrogen signaling pathway_Homo sapiens_hsa049151.22050528
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20598789
31Melanogenesis_Homo sapiens_hsa049161.20296841
32Inositol phosphate metabolism_Homo sapiens_hsa005621.20201409
33AMPK signaling pathway_Homo sapiens_hsa041521.17537136
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.12833869
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10126777
36Colorectal cancer_Homo sapiens_hsa052101.09582593
37Basal cell carcinoma_Homo sapiens_hsa052171.07156695
38Dorso-ventral axis formation_Homo sapiens_hsa043201.07048415
39Dilated cardiomyopathy_Homo sapiens_hsa054141.04934087
40Type II diabetes mellitus_Homo sapiens_hsa049301.04308502
41Axon guidance_Homo sapiens_hsa043601.02957887
42mRNA surveillance pathway_Homo sapiens_hsa030151.02106476
43Prostate cancer_Homo sapiens_hsa052151.01940843
44Oxytocin signaling pathway_Homo sapiens_hsa049211.01539763
45ABC transporters_Homo sapiens_hsa020101.01007997
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00566718
47Renal cell carcinoma_Homo sapiens_hsa052111.00192388
48Circadian entrainment_Homo sapiens_hsa047130.98791722
49Glutamatergic synapse_Homo sapiens_hsa047240.97747145
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97337919
51Adherens junction_Homo sapiens_hsa045200.96805044
52Pancreatic cancer_Homo sapiens_hsa052120.96703796
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.96367047
54Cholinergic synapse_Homo sapiens_hsa047250.93883093
55MAPK signaling pathway_Homo sapiens_hsa040100.93726633
56Bladder cancer_Homo sapiens_hsa052190.91918316
57Proteoglycans in cancer_Homo sapiens_hsa052050.91663185
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91168502
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91110923
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90999852
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90482837
62Long-term depression_Homo sapiens_hsa047300.89551478
63Glucagon signaling pathway_Homo sapiens_hsa049220.89533010
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86245331
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85510702
66Insulin secretion_Homo sapiens_hsa049110.85439916
67Insulin resistance_Homo sapiens_hsa049310.84251011
68Small cell lung cancer_Homo sapiens_hsa052220.84146684
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84110567
70Calcium signaling pathway_Homo sapiens_hsa040200.83237575
71Gastric acid secretion_Homo sapiens_hsa049710.82187955
72Prolactin signaling pathway_Homo sapiens_hsa049170.81763090
73Wnt signaling pathway_Homo sapiens_hsa043100.81462950
74Rap1 signaling pathway_Homo sapiens_hsa040150.81037883
75HIF-1 signaling pathway_Homo sapiens_hsa040660.80635617
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80521836
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76838751
78Gap junction_Homo sapiens_hsa045400.76138511
79FoxO signaling pathway_Homo sapiens_hsa040680.75390230
80cAMP signaling pathway_Homo sapiens_hsa040240.75150231
81Hippo signaling pathway_Homo sapiens_hsa043900.72263183
82Cocaine addiction_Homo sapiens_hsa050300.71199872
83Hedgehog signaling pathway_Homo sapiens_hsa043400.70331460
84Taste transduction_Homo sapiens_hsa047420.69570282
85Amphetamine addiction_Homo sapiens_hsa050310.69226933
86Pathways in cancer_Homo sapiens_hsa052000.68334976
87Nicotine addiction_Homo sapiens_hsa050330.67791585
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.67014622
89Morphine addiction_Homo sapiens_hsa050320.65455246
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64889389
91Ras signaling pathway_Homo sapiens_hsa040140.64255809
92Salivary secretion_Homo sapiens_hsa049700.63738599
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63486093
94Protein digestion and absorption_Homo sapiens_hsa049740.63101355
95Amoebiasis_Homo sapiens_hsa051460.62881355
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.61616552
97GABAergic synapse_Homo sapiens_hsa047270.61533506
98Thyroid cancer_Homo sapiens_hsa052160.61355633
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.60799737
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60490465

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