PIWIL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.68475134
2epithelial cilium movement (GO:0003351)9.61566298
3sperm-egg recognition (GO:0035036)9.52884337
4synaptonemal complex assembly (GO:0007130)9.51237837
5DNA methylation involved in gamete generation (GO:0043046)9.21138454
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.06450013
7cilium movement (GO:0003341)8.89733581
8binding of sperm to zona pellucida (GO:0007339)8.89147351
9motile cilium assembly (GO:0044458)8.84750089
10acrosome reaction (GO:0007340)8.79314735
11acrosome assembly (GO:0001675)8.76692886
12plasma membrane fusion (GO:0045026)8.65868182
13cell-cell recognition (GO:0009988)8.49563672
14male meiosis I (GO:0007141)8.09726367
15* spermatid development (GO:0007286)7.96813208
16reproduction (GO:0000003)7.62102953
17regulation of cilium movement (GO:0003352)7.57946559
18negative regulation of cytosolic calcium ion concentration (GO:0051481)7.23335559
19chromosome organization involved in meiosis (GO:0070192)6.79640569
20single fertilization (GO:0007338)6.75523940
21meiotic nuclear division (GO:0007126)6.68536548
22meiosis I (GO:0007127)6.59520594
23negative regulation of cAMP-mediated signaling (GO:0043951)6.54728737
24sperm capacitation (GO:0048240)6.47905634
25fertilization (GO:0009566)6.18073911
26regulation of meiosis I (GO:0060631)5.85552814
27negative regulation of inclusion body assembly (GO:0090084)5.78690104
28ventricular system development (GO:0021591)5.61912298
29ether lipid metabolic process (GO:0046485)5.55625095
30behavioral response to ethanol (GO:0048149)5.53908188
31protein localization to cilium (GO:0061512)5.49137828
32spermatogenesis (GO:0007283)5.34412678
33male gamete generation (GO:0048232)5.32593982
34cell wall macromolecule metabolic process (GO:0044036)5.27390811
35cell wall macromolecule catabolic process (GO:0016998)5.27390811
36* meiotic cell cycle (GO:0051321)5.08891516
37* germ cell development (GO:0007281)5.04834077
38* cellular process involved in reproduction in multicellular organism (GO:0022412)4.97883069
39gamete generation (GO:0007276)4.92327420
40seminiferous tubule development (GO:0072520)4.88708683
41gonadal mesoderm development (GO:0007506)4.85482650
42opioid receptor signaling pathway (GO:0038003)4.78234058
43genitalia morphogenesis (GO:0035112)4.70603648
44positive regulation of meiosis (GO:0045836)4.67884097
45adult feeding behavior (GO:0008343)4.63215695
46intraciliary transport (GO:0042073)4.63141050
47* gene silencing by RNA (GO:0031047)4.58600300
48left/right pattern formation (GO:0060972)4.56612516
49regulation of microtubule-based movement (GO:0060632)4.49112466
50regulation of inclusion body assembly (GO:0090083)4.42402692
51positive regulation of meiotic cell cycle (GO:0051446)4.39396838
52meiotic cell cycle process (GO:1903046)4.35525744
53microtubule severing (GO:0051013)4.34131335
54negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.29541185
55negative regulation of organelle assembly (GO:1902116)4.18570457
56glycerol ether metabolic process (GO:0006662)4.15357282
57cell recognition (GO:0008037)4.12808459
58axoneme assembly (GO:0035082)4.11744593
59monoubiquitinated protein deubiquitination (GO:0035520)4.07639333
60microtubule depolymerization (GO:0007019)4.05277215
61regulation of centriole replication (GO:0046599)4.04740602
62synapsis (GO:0007129)4.00609652
63protein polyglutamylation (GO:0018095)3.96328623
64ether metabolic process (GO:0018904)3.92271141
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.91389120
66multicellular organismal reproductive process (GO:0048609)3.86280014
67single strand break repair (GO:0000012)3.85047779
68calcium ion-dependent exocytosis (GO:0017156)3.83167509
69organic cation transport (GO:0015695)3.80898043
70pyrimidine dimer repair (GO:0006290)3.79280715
71microtubule-based movement (GO:0007018)3.72328462
72behavioral response to nicotine (GO:0035095)3.70600701
73DNA methylation (GO:0006306)3.70244376
74DNA alkylation (GO:0006305)3.70244376
75regulation of protein glycosylation (GO:0060049)3.68753842
76positive regulation of cAMP-mediated signaling (GO:0043950)3.68196207
77resolution of meiotic recombination intermediates (GO:0000712)3.63733545
78nuclear pore complex assembly (GO:0051292)3.62058227
79oogenesis (GO:0048477)3.59167780
80positive regulation of translational initiation (GO:0045948)3.51089711
81regulation of protein polyubiquitination (GO:1902914)3.50930889
82centriole replication (GO:0007099)3.48145420
83adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.44057610
84phosphatidylethanolamine biosynthetic process (GO:0006646)3.31874438
85cilium organization (GO:0044782)3.30047817
86DNA replication-dependent nucleosome organization (GO:0034723)3.29471215
87DNA replication-dependent nucleosome assembly (GO:0006335)3.29471215
88detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.29200482
89female gamete generation (GO:0007292)3.27039089
90protein targeting to Golgi (GO:0000042)3.26027041
91establishment of protein localization to Golgi (GO:0072600)3.24327327
92carnitine transmembrane transport (GO:1902603)3.23014561
93lactate metabolic process (GO:0006089)3.22295853
94cornea development in camera-type eye (GO:0061303)3.19721722
95amino-acid betaine transport (GO:0015838)3.14293199
96carnitine transport (GO:0015879)3.14293199
97phosphatidylethanolamine metabolic process (GO:0046337)3.14238537
98positive regulation of gastrulation (GO:2000543)3.14013389
99sex differentiation (GO:0007548)3.12788908
100cilium assembly (GO:0042384)3.12299773
101negative regulation of DNA repair (GO:0045738)3.10859246
102regulation of histone H3-K9 methylation (GO:0051570)3.09363141
103centriole assembly (GO:0098534)3.09182599
104response to pheromone (GO:0019236)3.03008664
105* multicellular organismal development (GO:0007275)3.02578058
106indolalkylamine metabolic process (GO:0006586)2.99233225
107translesion synthesis (GO:0019985)2.98615119
108ribosomal small subunit assembly (GO:0000028)2.97778090
109sister chromatid cohesion (GO:0007062)2.97747118
110DNA packaging (GO:0006323)2.97280748
111cilium morphogenesis (GO:0060271)2.96951646
112DNA synthesis involved in DNA repair (GO:0000731)2.96536473
113signal complex assembly (GO:0007172)2.95545240
114chaperone-mediated protein complex assembly (GO:0051131)2.95415879
115regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.94728687
116ubiquinone biosynthetic process (GO:0006744)2.93742483
117quinone biosynthetic process (GO:1901663)2.93300394
118* gene silencing (GO:0016458)2.91239807
119peptidyl-glutamic acid modification (GO:0018200)2.89145759
120detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88439257
121cellular component assembly involved in morphogenesis (GO:0010927)2.88370448
122nuclear pore organization (GO:0006999)2.88289615
123phosphatidylinositol acyl-chain remodeling (GO:0036149)2.87972850
124regulation of glutamate receptor signaling pathway (GO:1900449)2.86994151
125mitotic sister chromatid cohesion (GO:0007064)2.85811621
126reciprocal meiotic recombination (GO:0007131)2.83018579
127reciprocal DNA recombination (GO:0035825)2.83018579
128protein refolding (GO:0042026)2.82417996
129regulation of cAMP-mediated signaling (GO:0043949)2.81405086
130pore complex assembly (GO:0046931)2.80725885
131alditol metabolic process (GO:0019400)2.80429965
132neuronal action potential (GO:0019228)2.79737774
133phosphorelay signal transduction system (GO:0000160)2.78664081
134DNA methylation or demethylation (GO:0044728)2.77506900
135regulation of spindle checkpoint (GO:0090231)2.75137924
136regulation of chromatin binding (GO:0035561)2.74757982
137left/right axis specification (GO:0070986)2.73246201
138negative regulation of skeletal muscle tissue development (GO:0048642)2.61509431
139glycerol metabolic process (GO:0006071)2.53712598
140nucleoside diphosphate phosphorylation (GO:0006165)2.51241216
141nucleus organization (GO:0006997)2.51127227
142regulation of acrosome reaction (GO:0060046)2.46899653
143cilium or flagellum-dependent cell motility (GO:0001539)18.5857061
144* piRNA metabolic process (GO:0034587)12.5666554
145fusion of sperm to egg plasma membrane (GO:0007342)11.3813818
146male meiosis (GO:0007140)11.2856164
147axonemal dynein complex assembly (GO:0070286)11.0740256
148sperm motility (GO:0030317)10.4198750
149synaptonemal complex organization (GO:0070193)10.0242066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.91719973
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.08555444
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.32190640
4GBX2_23144817_ChIP-Seq_PC3_Human2.75065467
5* VDR_22108803_ChIP-Seq_LS180_Human2.71919742
6IGF1R_20145208_ChIP-Seq_DFB_Human2.63034425
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.39016125
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37581411
9FUS_26573619_Chip-Seq_HEK293_Human2.26607889
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23019373
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.22616920
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12683281
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.10546227
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.07940873
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05658637
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.05511581
17* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.1825595
18ELK4_26923725_Chip-Seq_MESODERM_Mouse1.94075142
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94074855
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.82940220
21ZNF274_21170338_ChIP-Seq_K562_Hela1.82351809
22TAF15_26573619_Chip-Seq_HEK293_Human1.82146122
23IRF1_19129219_ChIP-ChIP_H3396_Human1.79992325
24STAT3_23295773_ChIP-Seq_U87_Human1.71634460
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70538441
26P300_19829295_ChIP-Seq_ESCs_Human1.69851767
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69603278
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66482644
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65563539
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.62286206
31NANOG_19829295_ChIP-Seq_ESCs_Human1.59800978
32SOX2_19829295_ChIP-Seq_ESCs_Human1.59800978
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52008234
34* NANOG_20526341_ChIP-Seq_ESCs_Human1.51157129
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46414050
36VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.45523136
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.44801755
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.41511064
39STAT1_17558387_ChIP-Seq_HELA_Human1.41404345
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39590864
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38679871
42CBP_20019798_ChIP-Seq_JUKART_Human1.38679871
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38576790
44TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.37698250
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37343922
46RAC3_21632823_ChIP-Seq_H3396_Human1.36910594
47EWS_26573619_Chip-Seq_HEK293_Human1.36524190
48KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36158143
49* AR_25329375_ChIP-Seq_VCAP_Human1.35615926
50* RUNX2_22187159_ChIP-Seq_PCA_Human1.35275213
51CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34611860
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34142674
53ERA_21632823_ChIP-Seq_H3396_Human1.33600483
54PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.33152986
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32335794
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32335794
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31558820
58RNF2_27304074_Chip-Seq_NSC_Mouse1.30578064
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.30517196
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.29921668
61* REST_21632747_ChIP-Seq_MESCs_Mouse1.29566713
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29182227
63SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.28323470
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.27617533
65FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27255174
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24666763
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24660975
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24379758
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23623812
70HTT_18923047_ChIP-ChIP_STHdh_Human1.20489220
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20357770
72TCF4_22108803_ChIP-Seq_LS180_Human1.20074353
73TP53_22573176_ChIP-Seq_HFKS_Human1.18822950
74GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.18318435
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17390735
76BCAT_22108803_ChIP-Seq_LS180_Human1.16629372
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.16066104
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.15940855
79FOXH1_21741376_ChIP-Seq_EPCs_Human1.14993605
80* OCT4_20526341_ChIP-Seq_ESCs_Human1.14974818
81TCF4_23295773_ChIP-Seq_U87_Human1.14948219
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14734626
83NCOR_22424771_ChIP-Seq_293T_Human1.14415266
84* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12613212
85DROSHA_22980978_ChIP-Seq_HELA_Human1.11869368
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.11793616
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11576329
88OCT4_18555785_Chip-Seq_ESCs_Mouse1.10710684
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09837900
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09777525
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.09426521
92* KDM2B_26808549_Chip-Seq_REH_Human1.09307563
93CDX2_22108803_ChIP-Seq_LS180_Human1.08173191
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07988307
95STAT3_18555785_Chip-Seq_ESCs_Mouse1.07909156
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.07537423
97RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06960034
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06652761
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06564437
100AR_20517297_ChIP-Seq_VCAP_Human1.06342207
101CEBPB_22108803_ChIP-Seq_LS180_Human1.06125783
102HOXB7_26014856_ChIP-Seq_BT474_Human1.04818097
103MYC_19829295_ChIP-Seq_ESCs_Human1.04309582
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03732383
105SOX2_22085726_ChIP-Seq_NPCs_Mouse1.03045533
106KLF4_18555785_Chip-Seq_ESCs_Mouse1.02144086
107ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02125302
108* FOXH1_21741376_ChIP-Seq_ESCs_Human1.01928111
109EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01903468
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01873897
111ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01616412
112OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01526978
113AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01397103
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00778317
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00775452
116P53_22387025_ChIP-Seq_ESCs_Mouse1.00609410
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00263241
118STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99907878
119ETV1_20927104_ChIP-Seq_GIST48_Human0.99614160
120SMAD3_21741376_ChIP-Seq_ESCs_Human0.99177098
121GATA3_21867929_ChIP-Seq_TH1_Mouse0.98945204
122RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98499365
123* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98362127
124ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98359692
125* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98357025
126FLI1_21867929_ChIP-Seq_TH2_Mouse0.98323917
127SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97881221
128RXR_22108803_ChIP-Seq_LS180_Human0.97489723
129GATA3_21867929_ChIP-Seq_CD8_Mouse0.97223914
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96102802
131GF1_26923725_Chip-Seq_HPCs_Mouse0.95537071
132ER_23166858_ChIP-Seq_MCF-7_Human0.94875652
133CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93385900
134RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92984463
135SMAD4_21741376_ChIP-Seq_EPCs_Human0.92765377
136RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92669527
137* P300_18555785_Chip-Seq_ESCs_Mouse0.92658410
138LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.92346567
139CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90989446
140FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90627277
141SOX2_21211035_ChIP-Seq_LN229_Human0.90049063
142TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89896158
143SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89795729
144PU1_27457419_Chip-Seq_LIVER_Mouse0.88662648
145CMYC_18555785_Chip-Seq_ESCs_Mouse0.88567348
146TBL1_22424771_ChIP-Seq_293T_Human0.87500306
147NFYB_21822215_ChIP-Seq_K562_Human0.87369229
148P53_21459846_ChIP-Seq_SAOS-2_Human0.86976930
149STAT1_20625510_ChIP-Seq_HELA_Human0.86627525
150FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86430843
151FOXA1_25329375_ChIP-Seq_VCAP_Human0.86430843
152ZFX_18555785_Chip-Seq_ESCs_Mouse0.86128387
153SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85112654
154CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84605411
155* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84419399
156AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83417092
157E2F1_18555785_Chip-Seq_ESCs_Mouse0.83337847
158YY1_22570637_ChIP-Seq_MALME-3M_Human0.82986116
159SMAD4_21799915_ChIP-Seq_A2780_Human0.82286277

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.09959946
2* MP0003698_abnormal_male_reproductive5.68601294
3* MP0001929_abnormal_gametogenesis5.35562145
4* MP0002210_abnormal_sex_determination4.22168527
5MP0002653_abnormal_ependyma_morphology4.18080859
6MP0001968_abnormal_touch/_nociception3.61353493
7* MP0001145_abnormal_male_reproductive3.46268625
8MP0003880_abnormal_central_pattern3.14002469
9* MP0002161_abnormal_fertility/fecundity3.12133202
10MP0002876_abnormal_thyroid_physiology3.08683348
11* MP0000653_abnormal_sex_gland3.05090005
12MP0005623_abnormal_meninges_morphology2.69614548
13MP0008057_abnormal_DNA_replication2.60338825
14MP0006292_abnormal_olfactory_placode2.57619848
15MP0005503_abnormal_tendon_morphology2.56039071
16MP0005360_urolithiasis2.36324047
17MP0002160_abnormal_reproductive_system2.18629598
18MP0009780_abnormal_chondrocyte_physiolo2.09976381
19MP0001986_abnormal_taste_sensitivity2.07199438
20MP0003718_maternal_effect2.01351775
21MP0005410_abnormal_fertilization13.0862104
22MP0000678_abnormal_parathyroid_gland1.98863651
23MP0008995_early_reproductive_senescence1.95386076
24MP0004147_increased_porphyrin_level1.91012159
25MP0003646_muscle_fatigue1.76805452
26MP0010368_abnormal_lymphatic_system1.76616103
27MP0010094_abnormal_chromosome_stability1.76602534
28MP0005645_abnormal_hypothalamus_physiol1.76348986
29MP0008058_abnormal_DNA_repair1.74111523
30MP0009745_abnormal_behavioral_response1.69836246
31MP0002282_abnormal_trachea_morphology1.65509202
32MP0002272_abnormal_nervous_system1.65166409
33MP0001664_abnormal_digestion1.62085481
34MP0003786_premature_aging1.54158424
35MP0002733_abnormal_thermal_nociception1.53814944
36MP0000681_abnormal_thyroid_gland1.45749798
37MP0006035_abnormal_mitochondrial_morpho1.42252352
38MP0005647_abnormal_sex_gland1.40800347
39MP0001485_abnormal_pinna_reflex1.40797441
40MP0009046_muscle_twitch1.40119320
41MP0001501_abnormal_sleep_pattern1.39397594
42MP0001984_abnormal_olfaction1.33619647
43MP0003878_abnormal_ear_physiology1.33491540
44MP0005377_hearing/vestibular/ear_phenot1.33491540
45MP0008007_abnormal_cellular_replicative1.31754801
46MP0002638_abnormal_pupillary_reflex1.25704308
47MP0003183_abnormal_peptide_metabolism1.22120266
48MP0003195_calcinosis1.20455619
49MP0005670_abnormal_white_adipose1.17962709
50MP0002735_abnormal_chemical_nociception1.17884021
51MP0005389_reproductive_system_phenotype1.16482978
52MP0001970_abnormal_pain_threshold1.14191431
53MP0008872_abnormal_physiological_respon1.10244385
54MP0002067_abnormal_sensory_capabilities1.10021899
55MP0004142_abnormal_muscle_tone1.08149401
56MP0009764_decreased_sensitivity_to1.08004076
57MP0005167_abnormal_blood-brain_barrier1.06451204
58MP0004134_abnormal_chest_morphology1.06358724
59MP0000569_abnormal_digit_pigmentation1.05569470
60MP0003959_abnormal_lean_body1.04816640
61MP0008789_abnormal_olfactory_epithelium1.02976751
62MP0003633_abnormal_nervous_system1.00548669
63MP0002734_abnormal_mechanical_nocicepti0.99153803
64MP0005174_abnormal_tail_pigmentation0.97260079
65MP0003635_abnormal_synaptic_transmissio0.92877173
66MP0003567_abnormal_fetal_cardiomyocyte0.91022536
67MP0002736_abnormal_nociception_after0.89578258
68MP0003111_abnormal_nucleus_morphology0.88601265
69MP0002557_abnormal_social/conspecific_i0.88124547
70MP0000049_abnormal_middle_ear0.87911807
71MP0002138_abnormal_hepatobiliary_system0.83997343
72MP0006276_abnormal_autonomic_nervous0.83073088
73MP0003879_abnormal_hair_cell0.82723626
74MP0008775_abnormal_heart_ventricle0.81182637
75MP0004233_abnormal_muscle_weight0.79687217
76MP0001270_distended_abdomen0.79544914
77MP0001119_abnormal_female_reproductive0.79016703
78MP0003011_delayed_dark_adaptation0.78447005
79MP0005195_abnormal_posterior_eye0.78319124
80MP0005395_other_phenotype0.78012448
81MP0002064_seizures0.77749926
82MP0005379_endocrine/exocrine_gland_phen0.77165213
83MP0003699_abnormal_female_reproductive0.76933437
84MP0001765_abnormal_ion_homeostasis0.74784990
85MP0002063_abnormal_learning/memory/cond0.74369623
86MP0002249_abnormal_larynx_morphology0.74241186
87MP0000230_abnormal_systemic_arterial0.73670070
88MP0005084_abnormal_gallbladder_morpholo0.73664981
89MP0002752_abnormal_somatic_nervous0.72827570
90MP0000026_abnormal_inner_ear0.72307351
91MP0003136_yellow_coat_color0.72101401
92MP0004808_abnormal_hematopoietic_stem0.72022110
93MP0002095_abnormal_skin_pigmentation0.71942073
94MP0003950_abnormal_plasma_membrane0.71863715
95MP0002102_abnormal_ear_morphology0.71189459
96MP0000358_abnormal_cell_content/0.70928923
97MP0001188_hyperpigmentation0.70526922
98MP0005394_taste/olfaction_phenotype0.69615490
99MP0005499_abnormal_olfactory_system0.69615490
100MP0010386_abnormal_urinary_bladder0.68686715
101MP0000427_abnormal_hair_cycle0.66623789
102MP0003115_abnormal_respiratory_system0.59319061
103MP0009278_abnormal_bone_marrow0.57395124
104MP0001545_abnormal_hematopoietic_system0.54204942
105MP0005397_hematopoietic_system_phenotyp0.54204942
106MP0001727_abnormal_embryo_implantation0.52676648
107MP0003077_abnormal_cell_cycle0.51759139
108MP0010307_abnormal_tumor_latency0.49915099
109MP0001661_extended_life_span0.46808535
110MP0002928_abnormal_bile_duct0.46232682
111MP0005551_abnormal_eye_electrophysiolog0.45384738
112MP0003045_fibrosis0.44098765
113MP0005253_abnormal_eye_physiology0.41768858
114MP0002234_abnormal_pharynx_morphology0.39686705
115MP0001293_anophthalmia0.38988011
116MP0001851_eye_inflammation0.38944333
117MP0001730_embryonic_growth_arrest0.37317292
118MP0003861_abnormal_nervous_system0.37312915
119MP0005391_vision/eye_phenotype0.37160499
120MP0001440_abnormal_grooming_behavior0.36866530
121MP0000751_myopathy0.35545453
122MP0004742_abnormal_vestibular_system0.34970369
123MP0000313_abnormal_cell_death0.34566074
124MP0003329_amyloid_beta_deposits0.34485720
125MP0003787_abnormal_imprinting0.34441667
126MP0003936_abnormal_reproductive_system0.34435505
127MP0002152_abnormal_brain_morphology0.33830634
128MP0003283_abnormal_digestive_organ0.32828628
129MP0005423_abnormal_somatic_nervous0.29927842
130MP0005666_abnormal_adipose_tissue0.29644397
131MP0006138_congestive_heart_failure0.29589032
132MP0002971_abnormal_brown_adipose0.28902909
133MP0003693_abnormal_embryo_hatching0.28831700
134MP0000647_abnormal_sebaceous_gland0.28576857
135MP0005646_abnormal_pituitary_gland0.28399319
136MP0008961_abnormal_basal_metabolism0.27797334
137MP0002084_abnormal_developmental_patter0.27707155
138MP0000631_abnormal_neuroendocrine_gland0.27061856
139MP0001324_abnormal_eye_pigmentation0.25633241
140MP0006072_abnormal_retinal_apoptosis0.25596740
141MP0002572_abnormal_emotion/affect_behav0.24843636
142MP0000015_abnormal_ear_pigmentation0.24255786
143MP0001919_abnormal_reproductive_system0.23372405
144MP0004036_abnormal_muscle_relaxation0.23248903
145MP0004811_abnormal_neuron_physiology0.22737558
146MP0002092_abnormal_eye_morphology0.22626724
147MP0002229_neurodegeneration0.20550229
148MP0005636_abnormal_mineral_homeostasis0.20346426
149MP0003942_abnormal_urinary_system0.19633470
150MP0000778_abnormal_nervous_system0.19392148
151MP0000955_abnormal_spinal_cord0.18558687
152MP0001963_abnormal_hearing_physiology0.18222630
153MP0005380_embryogenesis_phenotype0.17606403
154MP0001672_abnormal_embryogenesis/_devel0.17606403
155MP0002108_abnormal_muscle_morphology0.16899880
156MP0008932_abnormal_embryonic_tissue0.16301272
157MP0004264_abnormal_extraembryonic_tissu0.15863299
158MP0000432_abnormal_head_morphology0.15616173
159MP0002114_abnormal_axial_skeleton0.15247723
160MP0001486_abnormal_startle_reflex0.15114410
161MP0002116_abnormal_craniofacial_bone0.14732697

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.89252824
2Abnormal respiratory motile cilium morphology (HP:0005938)8.21814765
3Abnormal respiratory epithelium morphology (HP:0012253)8.21814765
4Rhinitis (HP:0012384)7.97485338
5Abnormal ciliary motility (HP:0012262)7.21416386
6Thyroid-stimulating hormone excess (HP:0002925)7.09084397
7Chronic bronchitis (HP:0004469)6.43830966
8Infertility (HP:0000789)6.13404384
9Nasal polyposis (HP:0100582)6.03058137
10Nephronophthisis (HP:0000090)4.98264480
11Abnormality of the nasal mucosa (HP:0000433)4.90833881
12Bronchiectasis (HP:0002110)4.68991381
13Abnormality of the lower motor neuron (HP:0002366)4.46555107
14Bronchitis (HP:0012387)4.23896327
15Volvulus (HP:0002580)4.16007546
16Gonadotropin excess (HP:0000837)4.15144894
17Type II lissencephaly (HP:0007260)4.14415716
18Chronic hepatic failure (HP:0100626)3.98198843
19Abnormality of the renal medulla (HP:0100957)3.87140571
20Abnormality of the aortic arch (HP:0012303)3.49005140
21Intestinal atresia (HP:0011100)3.43451634
22Cerebellar dysplasia (HP:0007033)3.42703094
23Amyotrophic lateral sclerosis (HP:0007354)3.40857490
24Attenuation of retinal blood vessels (HP:0007843)3.31043831
25Tubulointerstitial nephritis (HP:0001970)3.30021963
26Osteomalacia (HP:0002749)3.23752498
27Fibular hypoplasia (HP:0003038)3.22964332
28Severe visual impairment (HP:0001141)3.19612496
29Recurrent otitis media (HP:0000403)3.18224948
30Retinal dysplasia (HP:0007973)3.15565317
31Male infertility (HP:0003251)3.13421137
32Progressive inability to walk (HP:0002505)3.11890750
33Recurrent sinusitis (HP:0011108)2.94200898
34Abnormal spermatogenesis (HP:0008669)2.91454485
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.87383739
36Abnormality of the ileum (HP:0001549)2.79465475
37Inability to walk (HP:0002540)2.78529319
38Recurrent bronchitis (HP:0002837)2.77273234
39Optic nerve hypoplasia (HP:0000609)2.75924716
40Pancreatic cysts (HP:0001737)2.70502128
41Mesangial abnormality (HP:0001966)2.70252748
42Impulsivity (HP:0100710)2.69128732
43Molar tooth sign on MRI (HP:0002419)2.68381446
44Abnormality of midbrain morphology (HP:0002418)2.68381446
45Azoospermia (HP:0000027)2.67796947
46Chromsome breakage (HP:0040012)2.66411822
47Impaired proprioception (HP:0010831)2.66150349
48Bony spicule pigmentary retinopathy (HP:0007737)2.62657150
49Abnormal rod and cone electroretinograms (HP:0008323)2.62551705
50Upper motor neuron abnormality (HP:0002127)2.55718484
51Postaxial foot polydactyly (HP:0001830)2.54979328
52Scotoma (HP:0000575)2.53240846
53Abnormality of macular pigmentation (HP:0008002)2.52819174
54Tubulointerstitial abnormality (HP:0001969)2.52765845
55Tubular atrophy (HP:0000092)2.51616002
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.51202128
57Focal motor seizures (HP:0011153)2.49551162
58Congenital stationary night blindness (HP:0007642)2.48564732
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.40449806
60Absent frontal sinuses (HP:0002688)2.39281033
61Medial flaring of the eyebrow (HP:0010747)2.38208108
62Pancreatic islet-cell hyperplasia (HP:0004510)2.37173553
63Agitation (HP:0000713)2.36180663
64Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35177684
65J-shaped sella turcica (HP:0002680)2.34240368
66Abnormality of the anterior horn cell (HP:0006802)2.33888242
67Degeneration of anterior horn cells (HP:0002398)2.33888242
68Lissencephaly (HP:0001339)2.33008865
69Supernumerary spleens (HP:0009799)2.30954380
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30475344
71Abnormality of alanine metabolism (HP:0010916)2.30475344
72Hyperalaninemia (HP:0003348)2.30475344
73Microglossia (HP:0000171)2.29454568
7411 pairs of ribs (HP:0000878)2.28359401
75Stage 5 chronic kidney disease (HP:0003774)2.26928792
76True hermaphroditism (HP:0010459)2.21909197
77Short ribs (HP:0000773)2.21632875
78Gastrointestinal atresia (HP:0002589)2.20055001
79Amelogenesis imperfecta (HP:0000705)2.19568306
80Truncal obesity (HP:0001956)2.16847503
81Abolished electroretinogram (ERG) (HP:0000550)2.16521123
82Keratoconus (HP:0000563)2.13492633
83Increased corneal curvature (HP:0100692)2.13492633
84Abnormal hemoglobin (HP:0011902)2.13219318
85Congenital hepatic fibrosis (HP:0002612)2.13035791
86Abnormality of DNA repair (HP:0003254)2.12943574
87Renal dysplasia (HP:0000110)2.11885904
88Aplasia/Hypoplasia of the uvula (HP:0010293)2.11427935
89Decreased central vision (HP:0007663)2.08964751
90Abnormality of dental color (HP:0011073)2.08028655
91Broad alveolar ridges (HP:0000187)2.05455806
92Aplasia/Hypoplasia of the fibula (HP:0006492)2.03452827
93Hyperventilation (HP:0002883)2.02761181
94Poikiloderma (HP:0001029)2.02602188
95Thickened helices (HP:0000391)2.01768943
96Epileptic encephalopathy (HP:0200134)2.01198621
97Oligodontia (HP:0000677)2.01042122
98Abnormality of dentin (HP:0010299)2.00702349
99Pendular nystagmus (HP:0012043)2.00351237
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1299925
101Dynein arm defect of respiratory motile cilia (HP:0012255)11.6344684
102Absent/shortened dynein arms (HP:0200106)11.6344684
103Spastic tetraparesis (HP:0001285)1.99239099
104Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.98592570
105Progressive cerebellar ataxia (HP:0002073)1.97921651
106Hypoplasia of the brainstem (HP:0002365)1.97831102
107Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97831102
108Abnormality of the labia minora (HP:0012880)1.95468490
109Neonatal respiratory distress (HP:0002643)1.95330225
110Short tibia (HP:0005736)1.94024720
111Abnormality of the renal cortex (HP:0011035)1.92792609
112Horseshoe kidney (HP:0000085)1.91548295
113Horizontal nystagmus (HP:0000666)1.90594797
114Oculomotor apraxia (HP:0000657)1.90556048
115Aplasia/Hypoplasia of the spleen (HP:0010451)1.89664875
116Large for gestational age (HP:0001520)1.89613587
117Median cleft lip (HP:0000161)1.89453081
118Abnormality of permanent molar morphology (HP:0011071)1.88438560
119Abnormality of the dental root (HP:0006486)1.88438560
120Taurodontia (HP:0000679)1.88438560
121Sclerocornea (HP:0000647)1.87252223
122Facial cleft (HP:0002006)1.86524369
123Triphalangeal thumb (HP:0001199)1.84966833
124Absent epiphyses (HP:0010577)1.83362233
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83362233
126Short thorax (HP:0010306)1.82394173
127Abnormality of the costochondral junction (HP:0000919)1.80934604
128Congenital ichthyosiform erythroderma (HP:0007431)1.80291123
129Abnormality of molar (HP:0011077)1.78911743
130Abnormality of molar morphology (HP:0011070)1.78911743
131Heterotopia (HP:0002282)1.78746671
132Tubulointerstitial fibrosis (HP:0005576)1.78668092
133Congenital primary aphakia (HP:0007707)1.78046412
134Gait imbalance (HP:0002141)1.77242630
135Polydipsia (HP:0001959)1.76256373
136Abnormal drinking behavior (HP:0030082)1.76256373
137Hyperglycinuria (HP:0003108)1.75441886
138Postaxial hand polydactyly (HP:0001162)1.75155492
139Polyuria (HP:0000103)1.74680648
140Broad-based gait (HP:0002136)1.74549174
141Male pseudohermaphroditism (HP:0000037)1.74087887
142Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.72657713
1433-Methylglutaconic aciduria (HP:0003535)1.72649941
144Cone-rod dystrophy (HP:0000548)1.71922785
145Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70578434
146Bile duct proliferation (HP:0001408)1.70364919
147Abnormal biliary tract physiology (HP:0012439)1.70364919
148Bell-shaped thorax (HP:0001591)1.70338416
149Chronic sinusitis (HP:0011109)1.68718818
150Abnormality of the dental pulp (HP:0006479)1.67603381
151Deformed sella turcica (HP:0002681)1.66678354
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.65806879
153Selective tooth agenesis (HP:0001592)1.64635617
154Large eyes (HP:0001090)1.56189111
155Conjunctival telangiectasia (HP:0000524)1.55804683
156Cystic liver disease (HP:0006706)1.53406450
157Decreased motor nerve conduction velocity (HP:0003431)1.51733615
158Nephroblastoma (Wilms tumor) (HP:0002667)1.50772835
159Pachygyria (HP:0001302)1.50593928
160Nephropathy (HP:0000112)1.50404467
161Pancreatic fibrosis (HP:0100732)1.48727599
162Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.48211858
163Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.47890097
164Gaze-evoked nystagmus (HP:0000640)1.46673016
165Broad distal phalanx of finger (HP:0009836)1.43610160
166Breast carcinoma (HP:0003002)1.43195479
167Embryonal renal neoplasm (HP:0011794)1.41264329
168Ectopic kidney (HP:0000086)1.40921230
169Cholecystitis (HP:0001082)1.40763406
170Abnormal gallbladder physiology (HP:0012438)1.40763406
171Sloping forehead (HP:0000340)1.40501281
172Abnormality of the epiphyses of the hand (HP:0005924)1.38946997
173Abnormality of ocular smooth pursuit (HP:0000617)1.36019261
174Hypoplasia of dental enamel (HP:0006297)1.34631184
175Abnormality of renal excretion (HP:0011036)1.33968259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.90417110
2PDK48.90417110
3ADRBK25.74162171
4PDK25.70398084
5FRK4.19095082
6ACVR1B4.04621977
7PRKD33.60545178
8TESK13.57730746
9PNCK3.16476369
10ICK3.09775077
11WNK42.64764764
12STK392.52783084
13PTK2B2.44593842
14NEK22.14048283
15INSRR2.02880601
16CDK191.98636778
17ZAK1.86541932
18TRIM281.85581448
19DAPK21.78362668
20RIPK11.76850784
21STK241.74919012
22MAP4K21.72684648
23TXK1.71127416
24ADRBK11.63381193
25MAPK151.61739457
26WNK11.50904250
27CDC71.44197331
28PLK21.42161091
29GRK11.40881812
30TAOK31.38645883
31STK381.24143471
32STK31.23079868
33PRKCE1.20392436
34TIE11.15919002
35NUAK11.12287162
36CCNB11.10783974
37BMPR1B1.08626181
38TYRO31.06935721
39PRKCI1.01164666
40TGFBR10.98428604
41TTK0.96472038
42RPS6KA60.93172425
43WEE10.85019087
44PASK0.84008797
45KIT0.83381145
46ATR0.82984631
47CDK80.81827619
48EPHA40.81551022
49MATK0.79709487
50OXSR10.79209415
51CAMK1G0.78970660
52CDK120.78494356
53DYRK1B0.74725492
54RPS6KL10.71006930
55RPS6KC10.71006930
56DAPK10.68468269
57RPS6KB20.68194473
58CHEK10.68098922
59PINK10.65545517
60PLK40.65230859
61PIK3CG0.58956430
62CAMK10.57359770
63WNK30.56885900
64STK38L0.55955407
65CHEK20.55861134
66PDK10.55585515
67DYRK30.53793799
68CSNK1G20.52320114
69BRSK20.52037955
70MET0.50696972
71MUSK0.50171872
72ATM0.50124898
73VRK10.47699053
74DYRK1A0.46762591
75MKNK10.42805833
76PLK10.42237201
77MAP3K40.41404898
78EEF2K0.40668308
79TEC0.39248816
80SGK10.39056028
81MTOR0.39015901
82BRSK10.37388292
83IRAK10.37097737
84GRK70.36571172
85TLK10.35772046
86PRKCA0.35609441
87MARK30.35219556
88IKBKB0.35150715
89CDK30.34912513
90NTRK20.34710201
91PRKACA0.34058104
92KSR20.33590839
93NME10.32241811
94PAK30.32237724
95PRKAA10.32113067
96MAP2K70.31863626
97CLK10.31676268
98LMTK20.31300582
99PAK60.29996878
100PRKAA20.28824303
101MAPK110.28697130
102TAOK10.28580572
103AURKA0.25126585
104MARK20.22743490
105PAK20.21576754
106BRAF0.21244780
107RPS6KB10.21192066
108PAK10.20867024
109MAPKAPK50.20321156
110PRKCG0.19641501
111CAMKK10.14819872
112CDK10.13374262
113LATS10.11468600
114CSNK1D0.11215499
115CDK70.10964264
116CDK20.09882296
117PRKACB0.09682334
118GSK3B0.09076236
119TNIK0.08933249
120PRKDC0.08659940
121NEK60.08003161
122CDK90.07204445
123SRPK10.05837050
124MAPK80.05597119
125MAP2K60.04012163
126MAPK100.03614257
127CASK0.03504083
128PRKG10.02838375
129CSNK2A10.02170442
130STK110.02045665
131RPS6KA30.01614439
132MAPK10.01284424
133CDK40.00952125
134BRD40.00732271
135NTRK30.00593722
136CSK-0.0456999
137EGFR-0.0445774
138PRKCZ-0.0416780
139TNK2-0.0408335
140RPS6KA1-0.0399730
141PRKCQ-0.0389578
142IRAK2-0.0382148
143AKT1-0.0368693
144PDPK1-0.0320775
145MAPK13-0.0304456
146CSNK2A2-0.0293990
147PRKACG-0.0277227
148PRKD2-0.0215252
149MAP3K5-0.0181044
150CAMK2A-0.0176252
151TESK2-0.0121263
152PDGFRB-0.0092511
153PRKCB-0.0060578
154YES1-0.0056252
155MAPK14-0.0028822

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.40437057
2Pyruvate metabolism_Homo sapiens_hsa006204.22454601
3Fanconi anemia pathway_Homo sapiens_hsa034603.82224900
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.63193669
5Basal transcription factors_Homo sapiens_hsa030223.19596956
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.94911220
7Propanoate metabolism_Homo sapiens_hsa006402.90277988
8Glucagon signaling pathway_Homo sapiens_hsa049222.87204506
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.75994147
10Selenocompound metabolism_Homo sapiens_hsa004502.61794579
11Phototransduction_Homo sapiens_hsa047442.58474501
12Fatty acid biosynthesis_Homo sapiens_hsa000612.56008979
13Pentose phosphate pathway_Homo sapiens_hsa000302.49992178
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.46582328
15Oocyte meiosis_Homo sapiens_hsa041142.41620664
16Huntingtons disease_Homo sapiens_hsa050162.36995161
17Butanoate metabolism_Homo sapiens_hsa006502.33816192
18Linoleic acid metabolism_Homo sapiens_hsa005912.30775398
19mRNA surveillance pathway_Homo sapiens_hsa030152.03314093
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.00245329
21RNA transport_Homo sapiens_hsa030131.88033194
22Glycerolipid metabolism_Homo sapiens_hsa005611.85768857
23Regulation of autophagy_Homo sapiens_hsa041401.78912644
24* Dorso-ventral axis formation_Homo sapiens_hsa043201.71027412
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70486632
26Tryptophan metabolism_Homo sapiens_hsa003801.63500694
27Amphetamine addiction_Homo sapiens_hsa050311.62626721
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61178110
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57973677
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.54085525
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.52946812
32Renin secretion_Homo sapiens_hsa049241.49674829
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.49083615
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48886047
35Sulfur relay system_Homo sapiens_hsa041221.47414309
36Homologous recombination_Homo sapiens_hsa034401.46170375
37Nitrogen metabolism_Homo sapiens_hsa009101.45186268
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.42671143
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.35231458
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35110797
41PPAR signaling pathway_Homo sapiens_hsa033201.26720087
42Antigen processing and presentation_Homo sapiens_hsa046121.24338405
43ABC transporters_Homo sapiens_hsa020101.23774054
44Base excision repair_Homo sapiens_hsa034101.21101760
45One carbon pool by folate_Homo sapiens_hsa006701.19943202
46Peroxisome_Homo sapiens_hsa041461.19033626
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17418708
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17252885
49Ether lipid metabolism_Homo sapiens_hsa005651.16893150
50Fructose and mannose metabolism_Homo sapiens_hsa000511.13401821
51RNA degradation_Homo sapiens_hsa030181.12928834
52Ribosome_Homo sapiens_hsa030101.11248474
53Cardiac muscle contraction_Homo sapiens_hsa042601.05819289
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04991448
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04686149
56Purine metabolism_Homo sapiens_hsa002301.02483791
57Carbon metabolism_Homo sapiens_hsa012001.00798248
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00071938
59Caffeine metabolism_Homo sapiens_hsa002320.98228823
60beta-Alanine metabolism_Homo sapiens_hsa004100.96180382
61Long-term potentiation_Homo sapiens_hsa047200.93935259
62Long-term depression_Homo sapiens_hsa047300.93740140
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93124927
64Salivary secretion_Homo sapiens_hsa049700.91005775
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88732691
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87637511
67Estrogen signaling pathway_Homo sapiens_hsa049150.87436869
68Calcium signaling pathway_Homo sapiens_hsa040200.84007608
69Fatty acid metabolism_Homo sapiens_hsa012120.80867271
70Serotonergic synapse_Homo sapiens_hsa047260.79503832
71Cell cycle_Homo sapiens_hsa041100.79409560
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78235110
73Mismatch repair_Homo sapiens_hsa034300.77344455
74N-Glycan biosynthesis_Homo sapiens_hsa005100.75868415
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74950089
76Sphingolipid metabolism_Homo sapiens_hsa006000.74580839
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71736057
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69886008
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.69428512
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66636370
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65119655
82Biosynthesis of amino acids_Homo sapiens_hsa012300.64829250
83VEGF signaling pathway_Homo sapiens_hsa043700.63876608
84RNA polymerase_Homo sapiens_hsa030200.63639107
85Fat digestion and absorption_Homo sapiens_hsa049750.63243355
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.62356028
87Mineral absorption_Homo sapiens_hsa049780.61819472
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60301140
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59273539
90Taste transduction_Homo sapiens_hsa047420.58326063
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56985648
92Inositol phosphate metabolism_Homo sapiens_hsa005620.56237076
93Starch and sucrose metabolism_Homo sapiens_hsa005000.52172367
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50922377
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49193594
96AMPK signaling pathway_Homo sapiens_hsa041520.48936826
97Graft-versus-host disease_Homo sapiens_hsa053320.48892218
98Fatty acid degradation_Homo sapiens_hsa000710.47610235
99Arachidonic acid metabolism_Homo sapiens_hsa005900.47439745
100Circadian entrainment_Homo sapiens_hsa047130.46883023
101GABAergic synapse_Homo sapiens_hsa047270.46674092
102Hedgehog signaling pathway_Homo sapiens_hsa043400.45971026
103Endocytosis_Homo sapiens_hsa041440.44016696
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43538030
105Nicotine addiction_Homo sapiens_hsa050330.43411367
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43307363
107Tyrosine metabolism_Homo sapiens_hsa003500.42231249
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.41817328
109Glutamatergic synapse_Homo sapiens_hsa047240.41517918
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.41408376
111Pancreatic secretion_Homo sapiens_hsa049720.40468784
112Ovarian steroidogenesis_Homo sapiens_hsa049130.39945271
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39844020
114Olfactory transduction_Homo sapiens_hsa047400.39256161
115Legionellosis_Homo sapiens_hsa051340.37054458
116Morphine addiction_Homo sapiens_hsa050320.36139667
117Non-homologous end-joining_Homo sapiens_hsa034500.35757456
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35209663
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.34203032
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32806522
121MAPK signaling pathway_Homo sapiens_hsa040100.32545552
122Wnt signaling pathway_Homo sapiens_hsa043100.32502716
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30880392
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30110145
125cAMP signaling pathway_Homo sapiens_hsa040240.29377214
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.29343475
127Retinol metabolism_Homo sapiens_hsa008300.28888160
128Insulin secretion_Homo sapiens_hsa049110.28840902
129Influenza A_Homo sapiens_hsa051640.28586336
130Oxytocin signaling pathway_Homo sapiens_hsa049210.28444890
131DNA replication_Homo sapiens_hsa030300.28213619
132Type I diabetes mellitus_Homo sapiens_hsa049400.27331186
133Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27167154
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.26426451
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25500505
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24602222
137Synaptic vesicle cycle_Homo sapiens_hsa047210.23589923
138Pyrimidine metabolism_Homo sapiens_hsa002400.23357696
139Metabolic pathways_Homo sapiens_hsa011000.22649209
140Nucleotide excision repair_Homo sapiens_hsa034200.22200647
141p53 signaling pathway_Homo sapiens_hsa041150.21379954
142Chemical carcinogenesis_Homo sapiens_hsa052040.21235481
143Spliceosome_Homo sapiens_hsa030400.19490671
144HTLV-I infection_Homo sapiens_hsa051660.17395036
145B cell receptor signaling pathway_Homo sapiens_hsa046620.17165683
146Vitamin digestion and absorption_Homo sapiens_hsa049770.16329533
147Viral carcinogenesis_Homo sapiens_hsa052030.15017722

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