PITPNC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the phosphatidylinositol transfer protein family. The encoded cytoplasmic protein plays a role in multiple processes including cell signaling and lipid metabolism by facilitating the transfer of phosphatidylinositol between membrane compartments. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of dendrite morphogenesis (GO:0050774)6.39372083
2peripheral nervous system neuron development (GO:0048935)5.49679801
3negative regulation of dendrite development (GO:2000171)5.27720899
4regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.66066174
5synaptic vesicle exocytosis (GO:0016079)4.29247287
6regulation of B cell receptor signaling pathway (GO:0050855)4.25036125
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.23180860
8cell migration in hindbrain (GO:0021535)4.08013090
9synaptic vesicle maturation (GO:0016188)4.05754521
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.05096147
11positive T cell selection (GO:0043368)4.03727329
12detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.97609511
13detection of temperature stimulus involved in sensory perception (GO:0050961)3.97609511
14positive regulation of Rap GTPase activity (GO:0032854)3.94925530
15regulation of ARF protein signal transduction (GO:0032012)3.81550278
16positive thymic T cell selection (GO:0045059)3.81402312
17regulation of relaxation of muscle (GO:1901077)3.74323107
18neuron cell-cell adhesion (GO:0007158)3.72859062
19detection of temperature stimulus (GO:0016048)3.69231578
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.68496036
21leukocyte aggregation (GO:0070486)3.62037532
22protein localization to synapse (GO:0035418)3.60927832
23neurofilament cytoskeleton organization (GO:0060052)3.58224688
24signal complex assembly (GO:0007172)3.58003609
25regulation of gamma-delta T cell activation (GO:0046643)3.56784869
26negative regulation of calcium ion transport into cytosol (GO:0010523)3.56277640
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.53849944
28negative regulation of homotypic cell-cell adhesion (GO:0034111)3.52646734
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.52128472
30negative regulation of cell killing (GO:0031342)3.49941799
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49941799
32T cell selection (GO:0045058)3.47562475
33regulation of Rap GTPase activity (GO:0032317)3.46274949
34regulation of synapse structural plasticity (GO:0051823)3.45970653
35negative T cell selection (GO:0043383)3.44464199
36activated T cell proliferation (GO:0050798)3.43285923
37negative thymic T cell selection (GO:0045060)3.43270999
38positive regulation of synaptic transmission, GABAergic (GO:0032230)3.41258538
39regulation of gamma-delta T cell differentiation (GO:0045586)3.40088229
40regulation of synaptic vesicle exocytosis (GO:2000300)3.37668755
41proline transport (GO:0015824)3.37039272
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.36016146
43positive regulation by organism of defense response of other organism involved in symbiotic interact3.36016146
44modulation by symbiont of host immune response (GO:0052553)3.36016146
45positive regulation by symbiont of host defense response (GO:0052509)3.36016146
46modulation by symbiont of host defense response (GO:0052031)3.36016146
47modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.36016146
48vocalization behavior (GO:0071625)3.34738245
49neuronal action potential (GO:0019228)3.34338867
50membrane depolarization during action potential (GO:0086010)3.33290722
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.33004127
52neuronal action potential propagation (GO:0019227)3.31197791
53cell communication by electrical coupling (GO:0010644)3.30773932
54neurotransmitter-gated ion channel clustering (GO:0072578)3.30463369
55L-amino acid import (GO:0043092)3.29204209
56positive regulation of cellular amide metabolic process (GO:0034250)3.27764238
57thymic T cell selection (GO:0045061)3.27506259
58antigen processing and presentation of endogenous antigen (GO:0019883)3.27280456
59serotonin receptor signaling pathway (GO:0007210)3.19683966
60nerve growth factor signaling pathway (GO:0038180)3.19274377
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17809647
62innervation (GO:0060384)3.16724310
63macrophage activation involved in immune response (GO:0002281)3.16707741
64negative regulation of lymphocyte mediated immunity (GO:0002707)3.16167072
65gamma-aminobutyric acid transport (GO:0015812)3.15359139
66glutamate secretion (GO:0014047)3.08667957
67behavioral response to pain (GO:0048266)3.08345639
68antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07571535
69regulation of synaptic vesicle transport (GO:1902803)3.06762580
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04762974
71negative regulation of leukocyte mediated immunity (GO:0002704)3.03596309
72negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03148818
73neurotransmitter secretion (GO:0007269)3.02475926
74postsynaptic membrane organization (GO:0001941)3.02428629
75regulation of glycogen (starch) synthase activity (GO:2000465)3.02208169
76regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.01370873
77negative regulation of T cell mediated immunity (GO:0002710)2.99506112
78regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.97087982
79negative regulation of interleukin-12 production (GO:0032695)2.96603478
80adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.96021725
81regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.95663990
82negative regulation of erythrocyte differentiation (GO:0045647)2.94109061
83ionotropic glutamate receptor signaling pathway (GO:0035235)2.93677233
84regulation of glutamate receptor signaling pathway (GO:1900449)2.92589716
85T cell migration (GO:0072678)2.89928640
86potassium ion export (GO:0071435)2.89567250
87urinary tract smooth muscle contraction (GO:0014848)2.89489483
88negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.89192715
89neuromuscular synaptic transmission (GO:0007274)2.88004356
90exploration behavior (GO:0035640)2.87319788
91regulation of short-term neuronal synaptic plasticity (GO:0048172)2.87115354
92positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.82543457
93synaptic vesicle docking involved in exocytosis (GO:0016081)2.82405558
94cellular response to interleukin-15 (GO:0071350)2.81850208
95presynaptic membrane assembly (GO:0097105)2.81511650
96regulation of isotype switching to IgG isotypes (GO:0048302)2.81361005
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.79426343
98regulation of membrane repolarization (GO:0060306)2.78221112
99regulation of platelet aggregation (GO:0090330)2.76815925
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.76351978
101membrane repolarization (GO:0086009)2.76255482
102negative regulation of neurotransmitter secretion (GO:0046929)2.76238418
103regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.75031849
104neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.74051970
105response to nerve growth factor (GO:1990089)2.72700622
106cellular response to nerve growth factor stimulus (GO:1990090)2.72700622
107regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.72474274
108response to interleukin-15 (GO:0070672)2.72339538
109regulation of cell communication by electrical coupling (GO:0010649)2.71513292
110neutrophil activation involved in immune response (GO:0002283)2.70247580
111positive regulation of granulocyte differentiation (GO:0030854)2.70242332
112regulation of T cell tolerance induction (GO:0002664)2.69306400
113response to muramyl dipeptide (GO:0032495)2.68542250
114negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.67997142
115regulation of beta-amyloid formation (GO:1902003)2.67846127
116cellular extravasation (GO:0045123)2.66573833
117G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.65501356
118myeloid dendritic cell differentiation (GO:0043011)2.65236680
119B cell receptor signaling pathway (GO:0050853)2.64869216
120negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.64041611
121regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62867035
122aggressive behavior (GO:0002118)2.62799057
123behavioral response to nicotine (GO:0035095)2.62516271
124dopamine receptor signaling pathway (GO:0007212)2.61534222
125detection of other organism (GO:0098543)2.60570176
126amino acid import (GO:0043090)2.58816151
127alanine transport (GO:0032328)2.58534618
128cellular response to type I interferon (GO:0071357)2.58382853
129type I interferon signaling pathway (GO:0060337)2.58382853
130response to peptidoglycan (GO:0032494)2.56251928
131locomotory exploration behavior (GO:0035641)2.55252047
132action potential (GO:0001508)2.55094149
133Rap protein signal transduction (GO:0032486)2.54695530
134generation of neurons (GO:0048699)2.54019372
135inositol phosphate catabolic process (GO:0071545)2.53973451
136response to type I interferon (GO:0034340)2.53898049
137positive regulation of potassium ion transmembrane transport (GO:1901381)2.53525409
138germinal center formation (GO:0002467)2.53436080
139response to pain (GO:0048265)2.53349825
140regulation of NFAT protein import into nucleus (GO:0051532)2.52456199
141positive regulation of gamma-delta T cell activation (GO:0046645)2.51696472
142cerebellar Purkinje cell differentiation (GO:0021702)2.51401511
143regulation of neuronal synaptic plasticity (GO:0048168)2.51129947
144cellular potassium ion homeostasis (GO:0030007)2.51016436
145positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.50723006
146calcium-mediated signaling using intracellular calcium source (GO:0035584)2.49668849
147interferon-gamma-mediated signaling pathway (GO:0060333)2.49441556
148detection of bacterium (GO:0016045)2.49085739
149regulation of synaptic transmission, glutamatergic (GO:0051966)2.47628088
150detection of mechanical stimulus involved in sensory perception (GO:0050974)2.47253332
151regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.46258890
152positive regulation of amino acid transport (GO:0051957)2.45263569
153interferon-gamma production (GO:0032609)2.44928847
154myeloid dendritic cell activation (GO:0001773)2.44921075
155T cell receptor signaling pathway (GO:0050852)2.44229253
156response to acidic pH (GO:0010447)2.43858283
157regulation of synaptic transmission, GABAergic (GO:0032228)2.43839672
158positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.43237602
159regulation of amyloid precursor protein catabolic process (GO:1902991)2.42940899
160response to auditory stimulus (GO:0010996)2.42883341
161regulation of defense response to virus by virus (GO:0050690)2.42758574
162antigen receptor-mediated signaling pathway (GO:0050851)2.42679714
163cell communication involved in cardiac conduction (GO:0086065)2.38985094
164regulation of natural killer cell mediated immunity (GO:0002715)2.38851906
165regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.38851906
166cellular response to prostaglandin stimulus (GO:0071379)2.38410561
167negative regulation of sodium ion transport (GO:0010766)2.38179438
168antigen processing and presentation via MHC class Ib (GO:0002475)2.37900428
169microglial cell activation (GO:0001774)2.37327725
170macrophage activation (GO:0042116)2.36884630
171regulation of interleukin-2 biosynthetic process (GO:0045076)2.35449155
172tolerance induction (GO:0002507)2.35293989
173myeloid cell activation involved in immune response (GO:0002275)2.35285019
174regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.34816719
175negative regulation of neurotransmitter transport (GO:0051589)2.34469797
176negative regulation of exocytosis (GO:0045920)2.33327806
177neutrophil activation (GO:0042119)2.33294130
178granulocyte activation (GO:0036230)2.32403496
179regulation of T-helper 2 cell differentiation (GO:0045628)2.31822618
180regulation of regulated secretory pathway (GO:1903305)2.30147118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.68823561
2EZH2_22144423_ChIP-Seq_EOC_Human3.46079181
3TAF15_26573619_Chip-Seq_HEK293_Human3.02175011
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.91389399
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.79566269
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.78370390
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68741274
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.64667658
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53031631
10* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.52689155
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48600301
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45011512
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41022344
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.40465354
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36865061
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.35208392
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32773765
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.28519207
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27356184
20REST_21632747_ChIP-Seq_MESCs_Mouse2.26433231
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.19781162
22SCL_19346495_ChIP-Seq_HPC-7_Human2.17361536
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16587850
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15670298
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14434840
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14134534
27KDM2B_26808549_Chip-Seq_DND41_Human2.14131235
28AR_21572438_ChIP-Seq_LNCaP_Human2.07896300
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05377563
30RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04742282
31EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04742282
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04712396
33* TCF7_22412390_ChIP-Seq_EML_Mouse2.04694974
34MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04100588
35* MYC_22102868_ChIP-Seq_BL_Human2.03914066
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03702859
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.00492424
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97513757
39P300_19829295_ChIP-Seq_ESCs_Human1.95583985
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92936432
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.90998096
42* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90565139
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.89030037
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86820606
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86245030
46RUNX_20019798_ChIP-Seq_JUKART_Human1.84333586
47* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83577601
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78200205
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.77686615
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.77029517
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76502777
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73867512
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73689079
54MYB_26560356_Chip-Seq_TH2_Human1.70723573
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.70571069
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.69666864
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68749394
58VDR_21846776_ChIP-Seq_THP-1_Human1.67953327
59SPI1_23127762_ChIP-Seq_K562_Human1.67363111
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.66507274
61* MAF_26560356_Chip-Seq_TH1_Human1.66076679
62KDM2B_26808549_Chip-Seq_K562_Human1.60073748
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.55676076
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55366920
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54515515
66AR_25329375_ChIP-Seq_VCAP_Human1.54304386
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54200887
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.53836247
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53681318
70DROSHA_22980978_ChIP-Seq_HELA_Human1.51609430
71VDR_24763502_ChIP-Seq_THP-1_Human1.50919194
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50900443
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48048026
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47430742
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45226069
76UTX_26944678_Chip-Seq_JUKART_Human1.44973981
77BCAT_22108803_ChIP-Seq_LS180_Human1.43752758
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43443642
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43059679
80MYB_26560356_Chip-Seq_TH1_Human1.43055771
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42913620
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42517417
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41619362
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41157546
85* VDR_24787735_ChIP-Seq_THP-1_Human1.40607656
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40060960
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39586165
88SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39086097
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.37981199
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.37084544
91RNF2_27304074_Chip-Seq_NSC_Mouse1.36586213
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36230083
93* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35196323
94* RARB_27405468_Chip-Seq_BRAIN_Mouse1.34437393
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32033148
96* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31792545
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30791344
98* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30627762
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30622690
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30187466
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.29942656
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29882384
103* ARNT_22903824_ChIP-Seq_MCF-7_Human1.29667642
104* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29254180
105* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29041678
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.28026917
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27857152
108* STAT3_23295773_ChIP-Seq_U87_Human1.26797444
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.26575260
110* AHR_22903824_ChIP-Seq_MCF-7_Human1.26215119
111BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26182605
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24121021
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22717726
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.22282688
115* GATA1_19941827_ChIP-Seq_MEL_Mouse1.22146195
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18516243
117MAF_26560356_Chip-Seq_TH2_Human1.17018349
118* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16150379
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16058967
120* GATA3_27048872_Chip-Seq_THYMUS_Human1.15297292
121* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14522953
122TCF4_23295773_ChIP-Seq_U87_Human1.14502096
123WT1_19549856_ChIP-ChIP_CCG9911_Human1.12989513
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12829196
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11002873
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10614044
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10191275
128PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09879393
129SPI1_23547873_ChIP-Seq_NB4_Human1.09730570
130CBX2_27304074_Chip-Seq_ESCs_Mouse1.09703936
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09378968
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09378968
133E2F1_18555785_Chip-Seq_ESCs_Mouse1.08632034
134HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08549694
135DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08197455
136* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08002934
137* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07556717
138PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07542292
139SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07481099
140JUN_21703547_ChIP-Seq_K562_Human1.06642170
141PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06378973
142NANOG_18555785_Chip-Seq_ESCs_Mouse1.05653914
143NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05647434
144BP1_19119308_ChIP-ChIP_Hs578T_Human1.05004061
145RUNX2_22187159_ChIP-Seq_PCA_Human1.04178037
146KDM2B_26808549_Chip-Seq_REH_Human1.03136922
147RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02214500
148EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02104141
149THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00514726
150MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00386589
151* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99843842
152* AR_19668381_ChIP-Seq_PC3_Human0.99654022
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98595343
154* PU_27001747_Chip-Seq_BMDM_Mouse0.98536041
155RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98107134
156CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97476641
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97466264
158MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97396459
159EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96418081
160* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95578525
161* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94879110
162P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94259590
163ER_23166858_ChIP-Seq_MCF-7_Human0.93979516
164* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93077983
165RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92124930
166* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91508068
167* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88053789
168* ESR2_21235772_ChIP-Seq_MCF-7_Human0.85662796
169* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85229534
170ELK3_25401928_ChIP-Seq_HUVEC_Human0.83993561
171* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82691135
172SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.79464091
173* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.79057142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception4.82689697
2MP0001968_abnormal_touch/_nociception3.85517579
3MP0003303_peritoneal_inflammation3.81504602
4MP0002736_abnormal_nociception_after3.68992092
5MP0001986_abnormal_taste_sensitivity3.39841319
6MP0004270_analgesia3.36886751
7MP0005646_abnormal_pituitary_gland2.89040029
8MP0002734_abnormal_mechanical_nocicepti2.85495750
9MP0006276_abnormal_autonomic_nervous2.81366420
10MP0003436_decreased_susceptibility_to2.73793172
11MP0002733_abnormal_thermal_nociception2.72199799
12MP0004859_abnormal_synaptic_plasticity2.70425986
13MP0003690_abnormal_glial_cell2.61723646
14MP0001188_hyperpigmentation2.56736413
15MP0003635_abnormal_synaptic_transmissio2.50257851
16MP0003300_gastrointestinal_ulcer2.49820190
17MP0001970_abnormal_pain_threshold2.38908545
18MP0003880_abnormal_central_pattern2.31918477
19MP0001800_abnormal_humoral_immune2.27922709
20MP0009745_abnormal_behavioral_response2.23751643
21MP0004858_abnormal_nervous_system2.19107158
22MP0005000_abnormal_immune_tolerance2.19069215
23MP0001984_abnormal_olfaction2.11359052
24MP0005423_abnormal_somatic_nervous2.08442452
25MP0002063_abnormal_learning/memory/cond2.05625273
26MP0004510_myositis2.01593608
27MP0009046_muscle_twitch1.97891183
28MP0002572_abnormal_emotion/affect_behav1.96228922
29MP0002064_seizures1.96150002
30MP0002272_abnormal_nervous_system1.96133089
31MP0002420_abnormal_adaptive_immunity1.96036465
32MP0002419_abnormal_innate_immunity1.94222669
33MP0001819_abnormal_immune_cell1.91837449
34MP0002723_abnormal_immune_serum1.90348644
35MP0001790_abnormal_immune_system1.89709217
36MP0005387_immune_system_phenotype1.89709217
37MP0002067_abnormal_sensory_capabilities1.88677253
38MP0003172_abnormal_lysosome_physiology1.85248504
39MP0005025_abnormal_response_to1.83995939
40MP0005645_abnormal_hypothalamus_physiol1.83899480
41MP0002452_abnormal_antigen_presenting1.83188513
42MP0001486_abnormal_startle_reflex1.82591664
43MP0000685_abnormal_immune_system1.69737434
44MP0005671_abnormal_response_to1.68388388
45MP0003787_abnormal_imprinting1.64766233
46MP0008569_lethality_at_weaning1.64349907
47MP0002184_abnormal_innervation1.63164456
48MP0009785_altered_susceptibility_to1.60652318
49MP0006082_CNS_inflammation1.58483749
50MP0000703_abnormal_thymus_morphology1.57230010
51MP0003646_muscle_fatigue1.55541442
52MP0002148_abnormal_hypersensitivity_rea1.54997242
53MP0003763_abnormal_thymus_physiology1.54661250
54MP0001348_abnormal_lacrimal_gland1.54404912
55MP0002398_abnormal_bone_marrow1.54371374
56MP0000920_abnormal_myelination1.54024728
57MP0002638_abnormal_pupillary_reflex1.52617047
58MP0003183_abnormal_peptide_metabolism1.51959823
59MP0000569_abnormal_digit_pigmentation1.49839884
60MP0000716_abnormal_immune_system1.48658232
61MP0002751_abnormal_autonomic_nervous1.47034053
62MP0004215_abnormal_myocardial_fiber1.44282327
63MP0004924_abnormal_behavior1.43972608
64MP0005386_behavior/neurological_phenoty1.43972608
65MP0002405_respiratory_system_inflammati1.43638286
66MP0003866_abnormal_defecation1.42410599
67MP0003075_altered_response_to1.37314796
68MP0005310_abnormal_salivary_gland1.35769154
69MP0008260_abnormal_autophagy1.35185970
70MP0004811_abnormal_neuron_physiology1.33042004
71MP0001851_eye_inflammation1.30134360
72MP0001501_abnormal_sleep_pattern1.29852294
73MP0004381_abnormal_hair_follicle1.29472421
74MP0002557_abnormal_social/conspecific_i1.29410169
75MP0004947_skin_inflammation1.28214376
76MP0001533_abnormal_skeleton_physiology1.27831885
77MP0000778_abnormal_nervous_system1.24751311
78MP0002822_catalepsy1.24013929
79MP0003279_aneurysm1.23157063
80MP0005394_taste/olfaction_phenotype1.22699331
81MP0005499_abnormal_olfactory_system1.22699331
82MP0004147_increased_porphyrin_level1.22329671
83MP0000751_myopathy1.21534584
84MP0008789_abnormal_olfactory_epithelium1.21058433
85MP0005464_abnormal_platelet_physiology1.20284113
86MP0009333_abnormal_splenocyte_physiolog1.19775691
87MP0000604_amyloidosis1.18356832
88MP0002998_abnormal_bone_remodeling1.17008964
89MP0004142_abnormal_muscle_tone1.14757391
90MP0002876_abnormal_thyroid_physiology1.14412425
91MP0003123_paternal_imprinting1.14144169
92MP0002722_abnormal_immune_system1.12772537
93MP0000689_abnormal_spleen_morphology1.12589048
94MP0009278_abnormal_bone_marrow1.10767215
95MP0001845_abnormal_inflammatory_respons1.10220892
96MP0006292_abnormal_olfactory_placode1.09585310
97MP0000015_abnormal_ear_pigmentation1.09404622
98MP0010155_abnormal_intestine_physiology1.08824870
99MP0005167_abnormal_blood-brain_barrier1.05021413
100MP0004036_abnormal_muscle_relaxation1.04744453
101MP0003634_abnormal_glial_cell1.04558183
102MP0000955_abnormal_spinal_cord1.03588259
103MP0001502_abnormal_circadian_rhythm1.02909098
104MP0002882_abnormal_neuron_morphology1.02838849
105MP0002429_abnormal_blood_cell1.02466326
106MP0004085_abnormal_heartbeat0.99848095
107MP0002837_dystrophic_cardiac_calcinosis0.98385615
108MP0000372_irregular_coat_pigmentation0.96528768
109MP0004885_abnormal_endolymph0.95402336
110MP0003091_abnormal_cell_migration0.95105958
111MP0003633_abnormal_nervous_system0.93081947
112MP0003137_abnormal_impulse_conducting0.92498507
113MP0005166_decreased_susceptibility_to0.91232992
114MP0001529_abnormal_vocalization0.90602692
115MP0005551_abnormal_eye_electrophysiolog0.90582299
116MP0004084_abnormal_cardiac_muscle0.90377776
117MP0009697_abnormal_copulation0.90211776
118MP0002066_abnormal_motor_capabilities/c0.89588249
119MP0001873_stomach_inflammation0.89175998
120MP0003879_abnormal_hair_cell0.88030367
121MP0004185_abnormal_adipocyte_glucose0.87962433
122MP0004484_altered_response_of0.87639165
123MP0009780_abnormal_chondrocyte_physiolo0.86416445
124MP0000858_altered_metastatic_potential0.86043311
125MP0001963_abnormal_hearing_physiology0.85608376
126MP0003448_altered_tumor_morphology0.84418543
127MP0000749_muscle_degeneration0.83759749
128MP0001270_distended_abdomen0.83662339
129MP0001835_abnormal_antigen_presentation0.83660285
130MP0003453_abnormal_keratinocyte_physiol0.82529865
131MP0008872_abnormal_physiological_respon0.82428289
132MP0004782_abnormal_surfactant_physiolog0.82053344
133MP0001440_abnormal_grooming_behavior0.80829725
134MP0004130_abnormal_muscle_cell0.80340109
135MP0002972_abnormal_cardiac_muscle0.79352287
136MP0003329_amyloid_beta_deposits0.78631868
137MP0005058_abnormal_lysosome_morphology0.78475214
138MP0008874_decreased_physiological_sensi0.78387081
139MP0002229_neurodegeneration0.78362042
140MP0002127_abnormal_cardiovascular_syste0.77989861
141MP0002693_abnormal_pancreas_physiology0.77443212
142MP0002909_abnormal_adrenal_gland0.77215504
143MP0001905_abnormal_dopamine_level0.76204695
144MP0000343_altered_response_to0.76176999
145MP0005409_darkened_coat_color0.75024026
146MP0002752_abnormal_somatic_nervous0.73763582
147MP0009764_decreased_sensitivity_to0.73094970
148MP0004808_abnormal_hematopoietic_stem0.72450984
149MP0005076_abnormal_cell_differentiation0.72384202
150MP0002332_abnormal_exercise_endurance0.71057669
151MP0003943_abnormal_hepatobiliary_system0.70996792
152MP0005535_abnormal_body_temperature0.70650327
153MP0000465_gastrointestinal_hemorrhage0.70544259
154MP0001853_heart_inflammation0.70055890
155MP0003631_nervous_system_phenotype0.68913508
156MP0002069_abnormal_eating/drinking_beha0.66560652
157MP0003724_increased_susceptibility_to0.64599528
158MP0002396_abnormal_hematopoietic_system0.63996995
159MP0001764_abnormal_homeostasis0.62642116
160MP0005174_abnormal_tail_pigmentation0.61774125
161MP0002152_abnormal_brain_morphology0.59507096
162MP0005075_abnormal_melanosome_morpholog0.59411521
163MP0008775_abnormal_heart_ventricle0.58740559

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)5.66736191
2Abnormal hair whorl (HP:0010721)5.04429315
3Myokymia (HP:0002411)4.76453272
4Eczematoid dermatitis (HP:0000976)4.73537750
5Stomatitis (HP:0010280)4.51796533
6Progressive cerebellar ataxia (HP:0002073)4.48346440
7Focal motor seizures (HP:0011153)4.37765213
8Hypothermia (HP:0002045)4.25085071
9Atonic seizures (HP:0010819)3.80454593
10Recurrent bacterial skin infections (HP:0005406)3.77493178
11Recurrent abscess formation (HP:0002722)3.51937313
12Epileptic encephalopathy (HP:0200134)3.45269597
13Action tremor (HP:0002345)3.44278823
14Myositis (HP:0100614)3.38582807
15Neurofibrillary tangles (HP:0002185)3.38107112
16Optic neuritis (HP:0100653)3.33652428
17Retrobulbar optic neuritis (HP:0100654)3.33652428
18Orchitis (HP:0100796)3.31374759
19Abnormality of macrophages (HP:0004311)3.29244844
20Ulnar claw (HP:0001178)3.22497630
21Papilledema (HP:0001085)3.19620351
22T lymphocytopenia (HP:0005403)3.19223572
23Focal seizures (HP:0007359)3.18701578
24Abnormality of binocular vision (HP:0011514)3.11168641
25Diplopia (HP:0000651)3.11168641
26Supranuclear gaze palsy (HP:0000605)3.00828814
27Impaired pain sensation (HP:0007328)2.92793193
28Abnormality of pain sensation (HP:0010832)2.92793193
29Elevated erythrocyte sedimentation rate (HP:0003565)2.90117334
30Pheochromocytoma (HP:0002666)2.89790418
31Mediastinal lymphadenopathy (HP:0100721)2.87867225
32Abnormality of T cell number (HP:0011839)2.79988380
33Neuroendocrine neoplasm (HP:0100634)2.76128999
34Meningitis (HP:0001287)2.74034797
35Visual hallucinations (HP:0002367)2.73720869
36Cerebral inclusion bodies (HP:0100314)2.72884989
37Recurrent fungal infections (HP:0002841)2.69336834
38Truncal ataxia (HP:0002078)2.66818711
39Spinal canal stenosis (HP:0003416)2.65135920
40Peripheral hypomyelination (HP:0007182)2.65048190
41Neuronal loss in central nervous system (HP:0002529)2.63830771
42Recurrent gram-negative bacterial infections (HP:0005420)2.62769877
43Sleep apnea (HP:0010535)2.59656599
44Neoplasm of the peripheral nervous system (HP:0100007)2.57785272
45Gaze-evoked nystagmus (HP:0000640)2.55006313
46Failure to thrive in infancy (HP:0001531)2.53536365
47Spontaneous hematomas (HP:0007420)2.51311779
48Vasculitis (HP:0002633)2.44849153
49Urinary bladder sphincter dysfunction (HP:0002839)2.44394838
50Slow saccadic eye movements (HP:0000514)2.41893526
51Disinhibition (HP:0000734)2.38346977
52Recurrent skin infections (HP:0001581)2.37482737
53Impaired vibration sensation in the lower limbs (HP:0002166)2.35199144
54Polyphagia (HP:0002591)2.34281515
55Lymphopenia (HP:0001888)2.32073722
56Generalized tonic-clonic seizures (HP:0002069)2.31226668
57Hemiplegia (HP:0002301)2.30295258
58Absence seizures (HP:0002121)2.29532776
59Gingivitis (HP:0000230)2.29135476
60Bradycardia (HP:0001662)2.27323291
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.26057259
62Abnormality of the nasal septum (HP:0000419)2.25536832
63Encephalitis (HP:0002383)2.25315156
64Inappropriate behavior (HP:0000719)2.24996826
65Cellulitis (HP:0100658)2.24691236
66Myotonia (HP:0002486)2.24601443
67Apathy (HP:0000741)2.22031987
68Chronic obstructive pulmonary disease (HP:0006510)2.21858788
69Obstructive lung disease (HP:0006536)2.21858788
70Poor suck (HP:0002033)2.20691903
71Chronic mucocutaneous candidiasis (HP:0002728)2.20131350
72Recurrent cutaneous fungal infections (HP:0011370)2.20131350
73Chest pain (HP:0100749)2.19269574
74Segmental peripheral demyelination/remyelination (HP:0003481)2.18548180
75Megalencephaly (HP:0001355)2.14987066
76Diminished motivation (HP:0000745)2.14560367
77Gait imbalance (HP:0002141)2.11756544
78Thickened helices (HP:0000391)2.11480310
79Episodic fever (HP:0001954)2.11362956
80Pulmonary infiltrates (HP:0002113)2.09195050
81Abnormal eating behavior (HP:0100738)2.09186214
82Increased IgE level (HP:0003212)2.08194322
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.07357599
84Narrow nasal bridge (HP:0000446)2.05245660
85Keratoconjunctivitis sicca (HP:0001097)2.03809284
86Fetal akinesia sequence (HP:0001989)2.03060884
87Increased cerebral lipofuscin (HP:0011813)2.02961135
88Impaired vibratory sensation (HP:0002495)2.02739101
89Subacute progressive viral hepatitis (HP:0006572)2.02645207
90Optic nerve hypoplasia (HP:0000609)2.02507875
91Gastrointestinal infarctions (HP:0005244)2.02430616
92Progressive inability to walk (HP:0002505)2.01352855
93Exercise-induced myalgia (HP:0003738)2.00769427
94Increased circulating renin level (HP:0000848)1.99830627
95Genetic anticipation (HP:0003743)1.99515657
96Dialeptic seizures (HP:0011146)1.98378953
97Leukocytosis (HP:0001974)1.96348555
98Pulmonary embolism (HP:0002204)1.96163372
99Ankle clonus (HP:0011448)1.96029231
100Increased CSF protein (HP:0002922)1.95458757
101Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95116753
102Gastrointestinal inflammation (HP:0004386)1.94499189
103Hemoptysis (HP:0002105)1.93915617
104Memory impairment (HP:0002354)1.93903887
105Sepsis (HP:0100806)1.90759183
106Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90710516
107Abnormality of liposaccharide metabolism (HP:0010968)1.90455069
108Abnormality of glycosphingolipid metabolism (HP:0004343)1.90455069
109Abnormality of glycolipid metabolism (HP:0010969)1.90455069
110Keratoconjunctivitis (HP:0001096)1.89484019
111Panhypogammaglobulinemia (HP:0003139)1.89457368
112Spastic gait (HP:0002064)1.89137830
113Thyroid carcinoma (HP:0002890)1.88907814
114Loss of speech (HP:0002371)1.88733888
115Amyotrophic lateral sclerosis (HP:0007354)1.88501345
116Urticaria (HP:0001025)1.88340502
117Tetraplegia (HP:0002445)1.88125730
118Depression (HP:0000716)1.87894176
119Atrial fibrillation (HP:0005110)1.87573541
120Mask-like facies (HP:0000298)1.87124594
121Inflammation of the large intestine (HP:0002037)1.86887799
122Pancreatic fibrosis (HP:0100732)1.86529898
123IgM deficiency (HP:0002850)1.86095271
124Palpebral edema (HP:0100540)1.86057165
125Gastrointestinal stroma tumor (HP:0100723)1.85211563
126Abnormality of the vocal cords (HP:0008777)1.85007861
127Neonatal hypoglycemia (HP:0001998)1.81962606
128Primary atrial arrhythmia (HP:0001692)1.80808964
129Annular pancreas (HP:0001734)1.80552438
130Anxiety (HP:0000739)1.80250778
131Limb ataxia (HP:0002070)1.79518098
132Slow-growing hair (HP:0002217)1.78341076
133Abnormality of hair growth rate (HP:0011363)1.78341076
134Areflexia of lower limbs (HP:0002522)1.78334298
135Mutism (HP:0002300)1.77396236
136Abnormality of T cells (HP:0002843)1.76175120
137Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76037968
138Amyloidosis (HP:0011034)1.75995611
139Macroorchidism (HP:0000053)1.75921782
140Nephrogenic diabetes insipidus (HP:0009806)1.75493365
141Congenital primary aphakia (HP:0007707)1.75195218
142Limb dystonia (HP:0002451)1.74492450
143Recurrent viral infections (HP:0004429)1.73422030
144Supraventricular tachycardia (HP:0004755)1.73152569
145Dysautonomia (HP:0002459)1.73094349
146Left ventricular hypertrophy (HP:0001712)1.72863928
147Agammaglobulinemia (HP:0004432)1.72708841
148Pustule (HP:0200039)1.72230788
149Stereotypic behavior (HP:0000733)1.71221592
150Medial flaring of the eyebrow (HP:0010747)1.68561570
151Horizontal nystagmus (HP:0000666)1.68390161
152Obstructive sleep apnea (HP:0002870)1.67825185
153Menstrual irregularities (HP:0000858)1.66033243
154Deeply set eye (HP:0000490)1.65923202
155Supraventricular arrhythmia (HP:0005115)1.64825197
156Septo-optic dysplasia (HP:0100842)1.64396380
157Abnormality of the columella (HP:0009929)1.64302142
158Hyperventilation (HP:0002883)1.63378023
159Poor coordination (HP:0002370)1.60936154
160Abnormality of ocular smooth pursuit (HP:0000617)1.60253361
161Abnormality of the fingertips (HP:0001211)1.59734014
162Specific learning disability (HP:0001328)1.59294238
163Prolonged QT interval (HP:0001657)1.58679047
164Bradykinesia (HP:0002067)1.58447399
165Urinary urgency (HP:0000012)1.58260998
166Subaortic stenosis (HP:0001682)1.57563757
167Abnormality of the left ventricular outflow tract (HP:0011103)1.57563757
168Impaired proprioception (HP:0010831)1.56700891
169Submucous cleft hard palate (HP:0000176)1.55350418
170Hemiparesis (HP:0001269)1.53519988
171Steppage gait (HP:0003376)1.52032596
172Postural tremor (HP:0002174)1.51705780
173Inability to walk (HP:0002540)1.51545645
174Truncal obesity (HP:0001956)1.50958548
175Broad-based gait (HP:0002136)1.47770651
176Poor eye contact (HP:0000817)1.47498123
177Central scotoma (HP:0000603)1.47267208
178Meningioma (HP:0002858)1.46733140
179Prolonged bleeding time (HP:0003010)1.46410110
180Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.46319922
181Abnormal EKG (HP:0003115)1.46000213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.57883790
2CASK3.25292633
3TXK3.05621111
4MAP2K73.03745749
5SGK23.03363974
6SIK32.95274520
7NTRK32.93571832
8MINK12.46133639
9TNIK2.31687554
10MAPK132.23826251
11PHKG12.22463596
12PHKG22.22463596
13TYRO32.13606355
14CAMKK12.13504589
15MARK12.06877633
16SGK32.02914263
17TAOK12.01774898
18SGK4941.87528181
19SGK2231.87528181
20MAP3K41.87417808
21PRPF4B1.86211877
22CSK1.85746778
23LMTK21.73579132
24TYK21.66544375
25FGFR31.63628336
26MAP3K141.60599498
27MUSK1.60574390
28EPHB11.60454613
29MKNK21.58420491
30STK241.48158261
31TNK21.44850613
32GRK51.42878583
33MAP3K131.42144659
34MAP2K41.42086722
35FGFR21.35665704
36TSSK61.34867197
37NTRK21.33076928
38AKT31.30906376
39IRAK41.30354731
40FGR1.29683624
41MARK21.25865541
42RPS6KA21.25249408
43HCK1.22843715
44TRIB31.21685316
45RIPK11.19936538
46GRK71.17582847
47NLK1.13717649
48BLK1.12897513
49PRKCH1.12381242
50YES11.11331732
51TIE11.11130393
52GRK61.07152992
53BTK1.05978823
54MAP3K11.05743126
55NTRK11.04630727
56MATK1.02884482
57FGFR41.02238731
58PRKCG1.00461119
59PLK20.98665653
60CDK80.98269559
61MAP3K90.97854037
62MAPKAPK30.97051592
63KSR20.96028424
64STK110.94361367
65MAP3K100.93928847
66IRAK20.93208218
67SIK10.92127310
68RIPK40.91727247
69RPS6KB10.91652910
70IRAK30.89714871
71DAPK10.89664535
72KIT0.89548142
73MAPK120.87668955
74IKBKE0.86230872
75MAP4K10.85545651
76JAK20.81981675
77PINK10.81751974
78RPS6KA60.81529475
79LYN0.81485428
80BMPR20.80673728
81TEC0.79216791
82JAK10.78858955
83CAMK40.78708994
84MKNK10.78069767
85EPHA30.78006294
86PRKCE0.76626019
87MAP3K110.75953861
88VRK10.75162088
89PDGFRB0.74285658
90ALK0.73926627
91SIK20.73640672
92RPS6KL10.72893443
93RPS6KC10.72893443
94EPHA40.68801632
95MAP2K30.68275852
96FES0.68137195
97ERN10.67992315
98MYLK0.67290750
99FYN0.65739192
100CSF1R0.65622021
101SYK0.64918061
102CDK50.64632908
103TAOK30.61892222
104ADRBK20.61763177
105MAP3K30.61491453
106STK380.60643025
107DAPK20.60099287
108TBK10.59015115
109MELK0.58158953
110ARAF0.57817546
111CAMK1G0.57565923
112DYRK1A0.57168964
113SGK10.55785302
114KSR10.55476213
115PDPK10.55293589
116JAK30.53672200
117PTK60.53196812
118IKBKB0.51732384
119ERBB30.51569186
120ITK0.49310115
121ROCK20.49165124
122CAMKK20.49110857
123CAMK1D0.48630238
124PASK0.48292559
125BMX0.47473004
126PRKCZ0.45622532
127MAP2K60.44607852
128ZAP700.44234692
129NEK60.44168793
130MAPK40.43806491
131HIPK20.43560915
132ADRBK10.43247368
133MAPK70.43077432
134RET0.42614513
135MAPK80.39595037
136PAK60.37921211
137PRKCQ0.37702389
138DYRK20.37285307
139CAMK2A0.36870292
140TRPM70.35592115
141LCK0.35559891
142UHMK10.35407847
143PIM20.34414133
144CAMK10.33495163
145BMPR1B0.32992104
146STK160.31567609
147PDK10.31047245
148PRKACA0.28186961
149NEK10.27442457

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.98180635
2Synaptic vesicle cycle_Homo sapiens_hsa047212.92466926
3Nicotine addiction_Homo sapiens_hsa050332.62643167
4Circadian entrainment_Homo sapiens_hsa047132.13873380
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.13035094
6Taste transduction_Homo sapiens_hsa047422.01759451
7Morphine addiction_Homo sapiens_hsa050321.97736752
8Osteoclast differentiation_Homo sapiens_hsa043801.94874450
9GABAergic synapse_Homo sapiens_hsa047271.90305727
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89796728
11Cholinergic synapse_Homo sapiens_hsa047251.79221075
12Insulin secretion_Homo sapiens_hsa049111.78609530
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73132589
14Long-term potentiation_Homo sapiens_hsa047201.66760811
15Glutamatergic synapse_Homo sapiens_hsa047241.64948781
16Dopaminergic synapse_Homo sapiens_hsa047281.64184574
17Serotonergic synapse_Homo sapiens_hsa047261.59481557
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56957901
19Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.56221702
20Calcium signaling pathway_Homo sapiens_hsa040201.54803493
21Phototransduction_Homo sapiens_hsa047441.54391558
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51878293
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50264597
24Leishmaniasis_Homo sapiens_hsa051401.48227141
25Primary immunodeficiency_Homo sapiens_hsa053401.46917698
26Salivary secretion_Homo sapiens_hsa049701.45673344
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43745854
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40192896
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37478305
30Renal cell carcinoma_Homo sapiens_hsa052111.36224284
31Amphetamine addiction_Homo sapiens_hsa050311.35000992
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34705202
33VEGF signaling pathway_Homo sapiens_hsa043701.33294913
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29843027
35Gastric acid secretion_Homo sapiens_hsa049711.22604733
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22094684
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.18242993
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18083484
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.18055191
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17601843
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15698951
42Renin secretion_Homo sapiens_hsa049241.14401651
43cAMP signaling pathway_Homo sapiens_hsa040241.14087157
44Allograft rejection_Homo sapiens_hsa053301.13408264
45Collecting duct acid secretion_Homo sapiens_hsa049661.10633255
46T cell receptor signaling pathway_Homo sapiens_hsa046601.09322534
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.07602830
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06699652
49Sphingolipid signaling pathway_Homo sapiens_hsa040711.06183427
50Estrogen signaling pathway_Homo sapiens_hsa049151.05856799
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05855693
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05399709
53Chronic myeloid leukemia_Homo sapiens_hsa052201.05387249
54Oxytocin signaling pathway_Homo sapiens_hsa049211.03361197
55Endometrial cancer_Homo sapiens_hsa052131.03232614
56TNF signaling pathway_Homo sapiens_hsa046681.01746958
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00512759
58mTOR signaling pathway_Homo sapiens_hsa041501.00082785
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98445775
60Pancreatic cancer_Homo sapiens_hsa052120.96160405
61Staphylococcus aureus infection_Homo sapiens_hsa051500.93638836
62Type II diabetes mellitus_Homo sapiens_hsa049300.91761780
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91282912
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88972904
65Toxoplasmosis_Homo sapiens_hsa051450.88766643
66Measles_Homo sapiens_hsa051620.88438050
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.87717053
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.87555327
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87166903
70Thyroid cancer_Homo sapiens_hsa052160.87079477
71MAPK signaling pathway_Homo sapiens_hsa040100.87079424
72Dilated cardiomyopathy_Homo sapiens_hsa054140.86936297
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86250781
74Malaria_Homo sapiens_hsa051440.85355863
75Hepatitis B_Homo sapiens_hsa051610.85049520
76Endocytosis_Homo sapiens_hsa041440.83596877
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82942805
78Prolactin signaling pathway_Homo sapiens_hsa049170.82325189
79Autoimmune thyroid disease_Homo sapiens_hsa053200.81515917
80Cocaine addiction_Homo sapiens_hsa050300.81431157
81Hepatitis C_Homo sapiens_hsa051600.80972149
82Influenza A_Homo sapiens_hsa051640.80775116
83Type I diabetes mellitus_Homo sapiens_hsa049400.80663183
84Viral myocarditis_Homo sapiens_hsa054160.80557829
85Chemokine signaling pathway_Homo sapiens_hsa040620.80300708
86Colorectal cancer_Homo sapiens_hsa052100.80072623
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79657525
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79604372
89Cardiac muscle contraction_Homo sapiens_hsa042600.79335037
90ErbB signaling pathway_Homo sapiens_hsa040120.79101473
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78714232
92Dorso-ventral axis formation_Homo sapiens_hsa043200.78636890
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78558051
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74245636
95GnRH signaling pathway_Homo sapiens_hsa049120.74178170
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73946607
97Hematopoietic cell lineage_Homo sapiens_hsa046400.73573718
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73056564
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71869731
100Antigen processing and presentation_Homo sapiens_hsa046120.71130402
101Melanoma_Homo sapiens_hsa052180.70482882
102Salmonella infection_Homo sapiens_hsa051320.70202629
103Long-term depression_Homo sapiens_hsa047300.69967470
104Insulin signaling pathway_Homo sapiens_hsa049100.68866001
105Notch signaling pathway_Homo sapiens_hsa043300.68149631
106Rap1 signaling pathway_Homo sapiens_hsa040150.67647631
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66988430
108Rheumatoid arthritis_Homo sapiens_hsa053230.66397078
109Melanogenesis_Homo sapiens_hsa049160.66320120
110Gap junction_Homo sapiens_hsa045400.65877050
111Pancreatic secretion_Homo sapiens_hsa049720.65642606
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65075357
113Herpes simplex infection_Homo sapiens_hsa051680.64519397
114Glucagon signaling pathway_Homo sapiens_hsa049220.63530811
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62476881
116Glioma_Homo sapiens_hsa052140.62101648
117Ras signaling pathway_Homo sapiens_hsa040140.61154931
118Regulation of autophagy_Homo sapiens_hsa041400.56531778
119B cell receptor signaling pathway_Homo sapiens_hsa046620.53531715
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.51897986
121Asthma_Homo sapiens_hsa053100.50893327
122Graft-versus-host disease_Homo sapiens_hsa053320.50734159
123Acute myeloid leukemia_Homo sapiens_hsa052210.49519218
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47999211
125African trypanosomiasis_Homo sapiens_hsa051430.46728222
126Inositol phosphate metabolism_Homo sapiens_hsa005620.46552543
127Non-small cell lung cancer_Homo sapiens_hsa052230.44741130
128Choline metabolism in cancer_Homo sapiens_hsa052310.44304422
129Phagosome_Homo sapiens_hsa041450.44145901
130Platelet activation_Homo sapiens_hsa046110.43741139
131Tuberculosis_Homo sapiens_hsa051520.43418259
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.43364952
133FoxO signaling pathway_Homo sapiens_hsa040680.42876848

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