PISD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the conversion of phosphatidylserine to phosphatidylethanolamine in the inner mitochondrial membrane. The encoded protein is active in phospholipid metabolism and interorganelle trafficking of phosphatidylserine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.94222169
2negative regulation of cell killing (GO:0031342)5.94222169
3macrophage activation involved in immune response (GO:0002281)5.10378219
4response to peptidoglycan (GO:0032494)5.00477275
5positive regulation of T cell cytokine production (GO:0002726)4.85858742
6antigen processing and presentation of endogenous antigen (GO:0019883)4.84292342
7detection of other organism (GO:0098543)4.70273801
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.67402691
9response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.46796214
10response to host immune response (GO:0052572)4.46796214
11detection of bacterium (GO:0016045)4.46099087
12detection of molecule of bacterial origin (GO:0032490)4.30726095
13regulation of B cell receptor signaling pathway (GO:0050855)4.22138894
14negative regulation of erythrocyte differentiation (GO:0045647)4.21849921
15positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.20404559
16regulation of autophagic vacuole assembly (GO:2000785)4.18151503
17detection of external biotic stimulus (GO:0098581)4.15866268
18leukocyte aggregation (GO:0070486)4.15310039
19neutrophil activation (GO:0042119)4.11726946
20response to host (GO:0075136)4.10084134
21response to host defenses (GO:0052200)4.10084134
22response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.10084134
23negative regulation of interleukin-12 production (GO:0032695)4.08141670
24cellular extravasation (GO:0045123)4.03282195
25negative regulation of lymphocyte mediated immunity (GO:0002707)3.91400773
26eosinophil chemotaxis (GO:0048245)3.89113432
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.88375158
28response to interleukin-15 (GO:0070672)3.83910912
29regulation of mast cell degranulation (GO:0043304)3.82678658
30granulocyte activation (GO:0036230)3.77916619
31regulation of gamma-delta T cell activation (GO:0046643)3.76151289
32negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.74303967
33myeloid cell activation involved in immune response (GO:0002275)3.74025992
34macrophage activation (GO:0042116)3.69095700
35regulation of vacuole organization (GO:0044088)3.66785889
36cellular response to exogenous dsRNA (GO:0071360)3.65536355
37negative regulation of leukocyte mediated immunity (GO:0002704)3.59544130
38neutrophil mediated immunity (GO:0002446)3.58149220
39cellular response to interleukin-15 (GO:0071350)3.55319655
40detection of biotic stimulus (GO:0009595)3.51361789
41positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.50239700
42leukocyte migration involved in inflammatory response (GO:0002523)3.49478110
43regulation of myeloid leukocyte mediated immunity (GO:0002886)3.47733792
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.46972224
45regulation of mast cell activation involved in immune response (GO:0033006)3.46105731
46regulation of chronic inflammatory response (GO:0002676)3.45325348
47regulation of T cell cytokine production (GO:0002724)3.40151313
48response to type I interferon (GO:0034340)3.39892676
49negative regulation of phagocytosis (GO:0050765)3.37058335
50regulation of leukocyte degranulation (GO:0043300)3.35628884
51regulation of interferon-beta biosynthetic process (GO:0045357)3.33494353
52negative regulation of T cell mediated immunity (GO:0002710)3.32397797
53eosinophil migration (GO:0072677)3.31946747
54response to muramyl dipeptide (GO:0032495)3.26514196
55leukocyte degranulation (GO:0043299)3.21737581
56regulation of regulated secretory pathway (GO:1903305)3.19452847
57positive regulation of monocyte chemotaxis (GO:0090026)3.19253299
58regulation of gamma-delta T cell differentiation (GO:0045586)3.15015705
59galactose catabolic process (GO:0019388)3.13288811
60DNA deamination (GO:0045006)3.11704696
61regulation of metalloenzyme activity (GO:0048552)3.08573995
62B cell receptor signaling pathway (GO:0050853)3.08416707
63regulation of mast cell activation (GO:0033003)3.07967367
64regulation of B cell differentiation (GO:0045577)3.07934268
65myeloid leukocyte mediated immunity (GO:0002444)3.07924593
66positive regulation of mast cell activation (GO:0033005)3.07881992
67negative regulation of innate immune response (GO:0045824)3.07348734
68regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.06705284
69positive regulation of B cell differentiation (GO:0045579)3.06088015
70germinal center formation (GO:0002467)3.05381680
71respiratory chain complex IV assembly (GO:0008535)3.05250601
72carnitine metabolic process (GO:0009437)3.02933599
73regulation of activation of Janus kinase activity (GO:0010533)3.02844304
74regulation of T-helper 2 cell differentiation (GO:0045628)2.95237272
75interferon-gamma secretion (GO:0072643)2.94411085
76phagocytosis, recognition (GO:0006910)2.91951783
77negative regulation of macroautophagy (GO:0016242)2.91249122
78regulation of T cell tolerance induction (GO:0002664)2.88375923
79oxidative phosphorylation (GO:0006119)2.88044004
80phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.87521670
81positive regulation of interferon-alpha production (GO:0032727)2.87367650
82positive regulation of cellular amide metabolic process (GO:0034250)2.87299732
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87006518
84ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.86435581
85nucleoside bisphosphate biosynthetic process (GO:0033866)2.86435581
86purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.86435581
87positive regulation of T cell differentiation in thymus (GO:0033089)2.85025930
88regulation of T cell chemotaxis (GO:0010819)2.83872183
89positive regulation of T cell chemotaxis (GO:0010820)2.83872183
90regulation of developmental pigmentation (GO:0048070)2.83809878
91myeloid leukocyte activation (GO:0002274)2.82470027
92interferon-gamma-mediated signaling pathway (GO:0060333)2.82223232
93regulation of chemokine-mediated signaling pathway (GO:0070099)2.81204213
94ether lipid metabolic process (GO:0046485)2.75503156
95negative regulation of glycoprotein metabolic process (GO:1903019)2.75370196
96positive regulation of Cdc42 GTPase activity (GO:0043089)2.74904656
97response to interferon-beta (GO:0035456)2.74352120
98positive regulation by symbiont of host defense response (GO:0052509)2.74212171
99modulation by symbiont of host defense response (GO:0052031)2.74212171
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.74212171
101modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.74212171
102positive regulation by organism of defense response of other organism involved in symbiotic interact2.74212171
103modulation by symbiont of host immune response (GO:0052553)2.74212171
104platelet dense granule organization (GO:0060155)2.72742653
105negative regulation of toll-like receptor signaling pathway (GO:0034122)2.71909128
106negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.71677276
107regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.71504778
108signal peptide processing (GO:0006465)2.71459838
109response to protozoan (GO:0001562)2.70065313
110cellular response to interferon-beta (GO:0035458)2.68195503
111regulation of tolerance induction (GO:0002643)2.67966220
112positive regulation of mast cell activation involved in immune response (GO:0033008)2.67812515
113positive regulation of mast cell degranulation (GO:0043306)2.67812515
114regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.66937073
115termination of RNA polymerase III transcription (GO:0006386)2.65550199
116transcription elongation from RNA polymerase III promoter (GO:0006385)2.65550199
117phagocytosis, engulfment (GO:0006911)2.65527353
118immunoglobulin mediated immune response (GO:0016064)2.64681105
119regulation of interferon-alpha production (GO:0032647)2.64085071
120negative regulation of cytokine production involved in immune response (GO:0002719)2.63824964
121phagosome maturation (GO:0090382)2.62739666
122negative regulation of interleukin-6 production (GO:0032715)2.61178557
123positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.60442206
124negative regulation of glycoprotein biosynthetic process (GO:0010561)2.59565285
125antigen processing and presentation via MHC class Ib (GO:0002475)2.58480715
126regulation of interleukin-12 biosynthetic process (GO:0045075)2.57810756
127regulation of vitamin metabolic process (GO:0030656)2.56056840
128cytochrome complex assembly (GO:0017004)2.55925795
129defense response to protozoan (GO:0042832)2.55676493
130neutrophil chemotaxis (GO:0030593)2.54854824
131T-helper 1 type immune response (GO:0042088)2.52336589
132positive regulation of gamma-delta T cell activation (GO:0046645)2.51646029
133production of molecular mediator involved in inflammatory response (GO:0002532)2.50846441
134nucleotide salvage (GO:0043173)2.50762673
135cytidine metabolic process (GO:0046087)2.50127884
136cytidine catabolic process (GO:0006216)2.50127884
137cytidine deamination (GO:0009972)2.50127884
138negative regulation of interleukin-17 production (GO:0032700)2.49984404
139purine nucleobase biosynthetic process (GO:0009113)2.49484971
140respiratory burst (GO:0045730)2.47693622
141ribosomal small subunit assembly (GO:0000028)2.46713862
142developmental pigmentation (GO:0048066)2.46219453
143negative regulation of T cell differentiation in thymus (GO:0033085)2.46085964
144positive regulation of T cell mediated immunity (GO:0002711)2.45265196
145proteasome assembly (GO:0043248)2.44919872
146regulation of mononuclear cell migration (GO:0071675)2.44411026
147nucleobase biosynthetic process (GO:0046112)2.42861849
148oligosaccharide catabolic process (GO:0009313)2.42168765
149iron-sulfur cluster assembly (GO:0016226)2.40964634
150metallo-sulfur cluster assembly (GO:0031163)2.40964634
151lipopolysaccharide-mediated signaling pathway (GO:0031663)2.40855298
152proline metabolic process (GO:0006560)2.38632025
153antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.38535506
154antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.38535506
155low-density lipoprotein particle remodeling (GO:0034374)2.36655099
156positive regulation of interleukin-10 production (GO:0032733)2.36596192
157regulation of pigment cell differentiation (GO:0050932)2.35777212
158purine nucleotide salvage (GO:0032261)2.35151636
159cGMP-mediated signaling (GO:0019934)2.35135473
160glycoside metabolic process (GO:0016137)2.34754576
161B cell mediated immunity (GO:0019724)2.32814255
162microglial cell activation (GO:0001774)2.31037965
163dendritic cell chemotaxis (GO:0002407)2.30287594
164cellular response to type I interferon (GO:0071357)2.30269009
165type I interferon signaling pathway (GO:0060337)2.30269009
166glycosphingolipid catabolic process (GO:0046479)2.29934080
167neutrophil activation involved in immune response (GO:0002283)2.29900923
168regulation of hydrogen peroxide-induced cell death (GO:1903205)2.29182297
169phospholipid scrambling (GO:0017121)2.28936840
170amino-acid betaine metabolic process (GO:0006577)2.28860647
171regulation of lymphocyte chemotaxis (GO:1901623)2.28737476
172positive regulation of interferon-beta production (GO:0032728)2.28220514
173positive regulation of interferon-gamma production (GO:0032729)2.28007151
174coenzyme A metabolic process (GO:0015936)2.27857412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.83389650
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.68729666
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.49684992
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.41360561
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.41352682
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.34730053
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.21488341
8E2F7_22180533_ChIP-Seq_HELA_Human3.18927878
9* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.84528812
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67742316
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59915307
12* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.58018384
13* MYC_22102868_ChIP-Seq_BL_Human2.54795882
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41977883
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.39642289
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.28130222
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.27902524
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27335208
19* MAF_26560356_Chip-Seq_TH1_Human2.25344607
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.22734123
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.20462830
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.18507135
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16449748
24* SRF_21415370_ChIP-Seq_HL-1_Mouse2.14915389
25KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11747822
26TCF7_22412390_ChIP-Seq_EML_Mouse2.08611587
27* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06576083
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05529088
29UTX_26944678_Chip-Seq_JUKART_Human2.04352705
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02292540
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.99986387
32KDM2B_26808549_Chip-Seq_DND41_Human1.97492714
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.97201226
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96829303
35LXR_22292898_ChIP-Seq_THP-1_Human1.96654476
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.95362601
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.92926926
38MAF_26560356_Chip-Seq_TH2_Human1.92842149
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.91571071
40* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.88500044
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84267236
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83285796
43* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82317623
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82301372
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78519660
46* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78309539
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77321888
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76312085
49* SPI1_23547873_ChIP-Seq_NB4_Human1.73870043
50* ELK3_25401928_ChIP-Seq_HUVEC_Human1.72208045
51* MYC_18555785_ChIP-Seq_MESCs_Mouse1.68433456
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68153623
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67571667
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65904448
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63343378
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60142778
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60022016
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59701486
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59371948
60* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59127484
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59073547
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58193778
63MYB_26560356_Chip-Seq_TH2_Human1.55069613
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54862352
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54683959
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52770396
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.52363476
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51319467
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.51182514
70MYB_26560356_Chip-Seq_TH1_Human1.48800277
71RACK7_27058665_Chip-Seq_MCF-7_Human1.47326275
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.45705521
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43158932
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41866668
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41434491
76BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.40485170
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40392439
78SCL_19346495_ChIP-Seq_HPC-7_Human1.39581805
79MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38804643
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38222215
81RUNX_20019798_ChIP-Seq_JUKART_Human1.38017505
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37744290
83P68_20966046_ChIP-Seq_HELA_Human1.35828905
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35158732
85* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35107147
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30755699
87* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30611479
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29791327
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.29485737
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28800158
91PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28442410
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.27575756
93* CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27333587
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27196140
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26823129
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25947721
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24993157
98FOXP3_21729870_ChIP-Seq_TREG_Human1.23928287
99NCOR1_26117541_ChIP-Seq_K562_Human1.23566852
100* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22865706
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22376548
102* VDR_23849224_ChIP-Seq_CD4+_Human1.21895166
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21528932
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21330953
105STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21254203
106DCP1A_22483619_ChIP-Seq_HELA_Human1.21200523
107MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20517550
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19884686
109* GATA1_19941826_ChIP-Seq_K562_Human1.19454104
110ELF1_20517297_ChIP-Seq_JURKAT_Human1.19354576
111* BCL6_27268052_Chip-Seq_Bcells_Human1.19100916
112IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18467402
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16923978
114CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15122930
115GATA3_27048872_Chip-Seq_THYMUS_Human1.14107111
116YY1_21170310_ChIP-Seq_MESCs_Mouse1.13655665
117KDM2B_26808549_Chip-Seq_JURKAT_Human1.13404354
118CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12482859
119SMC4_20622854_ChIP-Seq_HELA_Human1.11612418
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11281320
121GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11004383
122RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08848240
123CIITA_25753668_ChIP-Seq_RAJI_Human1.08647220
124STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08593082
125SPI1_23127762_ChIP-Seq_K562_Human1.08170450
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07591631
127EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07170672
128ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06453167
129TET1_21451524_ChIP-Seq_MESCs_Mouse1.04348132
130CTCF_26484167_Chip-Seq_Bcells_Mouse1.04347413
131TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04061260
132RXR_22158963_ChIP-Seq_LIVER_Mouse1.04020273
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02606104
134KDM2B_26808549_Chip-Seq_K562_Human1.02097065
135PU_27001747_Chip-Seq_BMDM_Mouse1.01085655
136TFEB_21752829_ChIP-Seq_HELA_Human1.00767222
137CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00343107
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99450966
139SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98007046
140* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97087842
141VDR_21846776_ChIP-Seq_THP-1_Human0.96539114
142PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96438238
143* P300_27268052_Chip-Seq_Bcells_Human0.95726994
144GATA1_22025678_ChIP-Seq_K562_Human0.95007633
145ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93912638
146* BCOR_27268052_Chip-Seq_Bcells_Human0.93246174
147VDR_24763502_ChIP-Seq_THP-1_Human0.91840810
148GABP_19822575_ChIP-Seq_HepG2_Human0.91438419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ3.06545721
2MP0005174_abnormal_tail_pigmentation3.04955030
3MP0002148_abnormal_hypersensitivity_rea2.97855075
4MP0005058_abnormal_lysosome_morphology2.86201499
5MP0003436_decreased_susceptibility_to2.83258772
6MP0009379_abnormal_foot_pigmentation2.79094653
7MP0001835_abnormal_antigen_presentation2.70328713
8MP0003191_abnormal_cellular_cholesterol2.66583602
9MP0003172_abnormal_lysosome_physiology2.63997693
10MP0003724_increased_susceptibility_to2.51308365
11MP0005671_abnormal_response_to2.47962100
12MP0009785_altered_susceptibility_to2.44850537
13MP0003878_abnormal_ear_physiology2.33738736
14MP0005377_hearing/vestibular/ear_phenot2.33738736
15MP0002254_reproductive_system_inflammat2.30641393
16MP0005360_urolithiasis2.22133512
17MP0002419_abnormal_innate_immunity2.21213468
18MP0000015_abnormal_ear_pigmentation2.19418008
19MP0009278_abnormal_bone_marrow2.16873112
20MP0009840_abnormal_foam_cell2.10744186
21MP0005025_abnormal_response_to2.07981173
22MP0005451_abnormal_body_composition2.06653171
23MP0003186_abnormal_redox_activity2.00698609
24MP0005000_abnormal_immune_tolerance1.98199739
25MP0003183_abnormal_peptide_metabolism1.86501513
26MP0001666_abnormal_nutrient_absorption1.81753242
27MP0003866_abnormal_defecation1.79547504
28MP0010329_abnormal_lipoprotein_level1.79232902
29MP0001790_abnormal_immune_system1.78186368
30MP0005387_immune_system_phenotype1.78186368
31MP0002723_abnormal_immune_serum1.73978666
32MP0002452_abnormal_antigen_presenting1.72541344
33MP0008260_abnormal_autophagy1.70814876
34MP0010155_abnormal_intestine_physiology1.70724765
35MP0009697_abnormal_copulation1.68615682
36MP0001800_abnormal_humoral_immune1.67100358
37MP0001853_heart_inflammation1.65427587
38MP0003303_peritoneal_inflammation1.59858816
39MP0005464_abnormal_platelet_physiology1.58108262
40MP0000604_amyloidosis1.57817250
41MP0008469_abnormal_protein_level1.57680631
42MP0002420_abnormal_adaptive_immunity1.56628979
43MP0008004_abnormal_stomach_pH1.55978525
44MP0001819_abnormal_immune_cell1.55826908
45MP0001533_abnormal_skeleton_physiology1.53762055
46MP0002139_abnormal_hepatobiliary_system1.52420369
47MP0003075_altered_response_to1.49613396
48MP0004947_skin_inflammation1.46718863
49MP0003656_abnormal_erythrocyte_physiolo1.43699614
50MP0003828_pulmonary_edema1.42152782
51MP0001845_abnormal_inflammatory_respons1.38100538
52MP0001188_hyperpigmentation1.37886306
53MP0004019_abnormal_vitamin_homeostasis1.35536213
54MP0001986_abnormal_taste_sensitivity1.34075810
55MP0004381_abnormal_hair_follicle1.33869492
56MP0000371_diluted_coat_color1.32633485
57MP0000703_abnormal_thymus_morphology1.30093075
58MP0003806_abnormal_nucleotide_metabolis1.27961296
59MP0000685_abnormal_immune_system1.27332626
60MP0003300_gastrointestinal_ulcer1.26161210
61MP0003252_abnormal_bile_duct1.24302993
62MP0000569_abnormal_digit_pigmentation1.23433748
63MP0001663_abnormal_digestive_system1.21702220
64MP0004782_abnormal_surfactant_physiolog1.19633856
65MP0002396_abnormal_hematopoietic_system1.18990350
66MP0003690_abnormal_glial_cell1.17718560
67MP0009643_abnormal_urine_homeostasis1.16897126
68MP0000465_gastrointestinal_hemorrhage1.16818775
69MP0001764_abnormal_homeostasis1.16807854
70MP0000343_altered_response_to1.13687008
71MP0005310_abnormal_salivary_gland1.12656273
72MP0003011_delayed_dark_adaptation1.11970869
73MP0009780_abnormal_chondrocyte_physiolo1.10032879
74MP0004510_myositis1.06862500
75MP0005381_digestive/alimentary_phenotyp1.06514334
76MP0004883_abnormal_blood_vessel1.06483842
77MP0000490_abnormal_crypts_of1.05947126
78MP0001873_stomach_inflammation1.05681164
79MP0010234_abnormal_vibrissa_follicle1.05506571
80MP0005332_abnormal_amino_acid1.02320102
81MP0003329_amyloid_beta_deposits1.02073213
82MP0000689_abnormal_spleen_morphology1.01641787
83MP0006082_CNS_inflammation1.01556930
84MP0002118_abnormal_lipid_homeostasis1.01295112
85MP0005166_decreased_susceptibility_to1.00855260
86MP0000716_abnormal_immune_system1.00762601
87MP0008874_decreased_physiological_sensi1.00726799
88MP0005319_abnormal_enzyme/_coenzyme1.00657812
89MP0002405_respiratory_system_inflammati0.95177245
90MP0003566_abnormal_cell_adhesion0.94705315
91MP0002998_abnormal_bone_remodeling0.94205391
92MP0009333_abnormal_splenocyte_physiolog0.93807899
93MP0002277_abnormal_respiratory_mucosa0.93231414
94MP0005164_abnormal_response_to0.92471438
95MP0002398_abnormal_bone_marrow0.90403402
96MP0002429_abnormal_blood_cell0.90282503
97MP0002736_abnormal_nociception_after0.90152510
98MP0005171_absent_coat_pigmentation0.89251924
99MP0001851_eye_inflammation0.88274127
100MP0005167_abnormal_blood-brain_barrier0.88035108
101* MP0005584_abnormal_enzyme/coenzyme_acti0.86351099
102MP0005075_abnormal_melanosome_morpholog0.86029631
103MP0002132_abnormal_respiratory_system0.85756748
104MP0004858_abnormal_nervous_system0.85027902
105MP0005083_abnormal_biliary_tract0.85011972
106MP0002006_tumorigenesis0.85004204
107MP0009764_decreased_sensitivity_to0.84888621
108MP0000609_abnormal_liver_physiology0.83887368
109MP0004808_abnormal_hematopoietic_stem0.83813641
110MP0009765_abnormal_xenobiotic_induced0.81900946
111MP0003763_abnormal_thymus_physiology0.81625044
112MP0002722_abnormal_immune_system0.80458612
113MP0005535_abnormal_body_temperature0.80058223
114MP0002136_abnormal_kidney_physiology0.79903050
115MP0000858_altered_metastatic_potential0.79580135
116MP0000249_abnormal_blood_vessel0.79231722
117MP0004859_abnormal_synaptic_plasticity0.79193288
118MP0005397_hematopoietic_system_phenotyp0.78334540
119MP0001545_abnormal_hematopoietic_system0.78334540
120MP0000462_abnormal_digestive_system0.77791645
121MP0009763_increased_sensitivity_to0.74428150
122MP0003221_abnormal_cardiomyocyte_apopto0.72079266
123MP0005076_abnormal_cell_differentiation0.71901345
124MP0005390_skeleton_phenotype0.71133288
125MP0008873_increased_physiological_sensi0.70688199
126MP0000920_abnormal_myelination0.69718518
127MP0003448_altered_tumor_morphology0.66815501
128MP0002693_abnormal_pancreas_physiology0.63316141
129MP0002019_abnormal_tumor_incidence0.61335878
130MP0005334_abnormal_fat_pad0.59993826
131MP0002971_abnormal_brown_adipose0.59630211
132MP0009115_abnormal_fat_cell0.56536474
133MP0003045_fibrosis0.56120647
134MP0002928_abnormal_bile_duct0.53085134
135MP0002970_abnormal_white_adipose0.52791557
136MP0003795_abnormal_bone_structure0.52635619

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)4.30954773
2Chronic obstructive pulmonary disease (HP:0006510)4.05445197
3Obstructive lung disease (HP:0006536)4.05445197
4Increased neuronal autofluorescent lipopigment (HP:0002074)3.81284561
5Recurrent fungal infections (HP:0002841)3.75651631
6Increased cerebral lipofuscin (HP:0011813)3.75164659
7Meningitis (HP:0001287)3.69312925
8Gastrointestinal infarctions (HP:0005244)3.40430610
9Posterior subcapsular cataract (HP:0007787)3.38111225
10Recurrent abscess formation (HP:0002722)3.35871355
11Hypochromic microcytic anemia (HP:0004840)3.25961712
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.21243866
13Cellulitis (HP:0100658)3.19643529
14Keratoconjunctivitis sicca (HP:0001097)3.18243797
15Increased IgE level (HP:0003212)3.16763936
16Dysostosis multiplex (HP:0000943)3.15544096
17Encephalitis (HP:0002383)3.14790513
18Recurrent bacterial skin infections (HP:0005406)3.12422861
19Hypochromic anemia (HP:0001931)3.08908920
20Episodic fever (HP:0001954)3.08326787
21Prolonged bleeding time (HP:0003010)3.06027317
22Recurrent cutaneous fungal infections (HP:0011370)3.02870435
23Chronic mucocutaneous candidiasis (HP:0002728)3.02870435
24Vasculitis (HP:0002633)2.96807015
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.95035715
26Abnormality of the heme biosynthetic pathway (HP:0010472)2.94585398
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.90226095
28Keratoconjunctivitis (HP:0001096)2.86515596
29Elevated erythrocyte sedimentation rate (HP:0003565)2.84769230
30Abnormality of glycolipid metabolism (HP:0010969)2.81723009
31Abnormality of liposaccharide metabolism (HP:0010968)2.81723009
32Abnormality of glycosphingolipid metabolism (HP:0004343)2.81723009
33Flared iliac wings (HP:0002869)2.74714033
34Hepatic necrosis (HP:0002605)2.72848875
35Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.72539188
36Hepatocellular necrosis (HP:0001404)2.70580855
37Abnormal gallbladder physiology (HP:0012438)2.65950180
38Cholecystitis (HP:0001082)2.65950180
39Hepatosplenomegaly (HP:0001433)2.65892982
40Agnosia (HP:0010524)2.65230411
41Spontaneous hematomas (HP:0007420)2.63514274
42Methylmalonic aciduria (HP:0012120)2.62745162
43Systemic lupus erythematosus (HP:0002725)2.61977712
44Recurrent gram-negative bacterial infections (HP:0005420)2.61219100
45Abnormality of macrophages (HP:0004311)2.58426739
46Hyperglycinuria (HP:0003108)2.58026292
47Chest pain (HP:0100749)2.54761371
48Flat capital femoral epiphysis (HP:0003370)2.54393704
49Dicarboxylic aciduria (HP:0003215)2.53711032
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53711032
51Increased intramyocellular lipid droplets (HP:0012240)2.53317152
52Osteomyelitis (HP:0002754)2.49300251
53Gastrointestinal inflammation (HP:0004386)2.47752400
54Esophageal neoplasm (HP:0100751)2.47511300
55Neoplasm of head and neck (HP:0012288)2.47511300
56Inflammation of the large intestine (HP:0002037)2.46844615
57Slow saccadic eye movements (HP:0000514)2.43899189
58Vertebral hypoplasia (HP:0008417)2.42755802
59Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.42755802
60Increased IgM level (HP:0003496)2.41616897
61Stomatitis (HP:0010280)2.41044042
62Eczematoid dermatitis (HP:0000976)2.40948769
63Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.39933231
64Vertebral clefting (HP:0008428)2.39500766
65Myositis (HP:0100614)2.38709085
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.37800531
67Hemoptysis (HP:0002105)2.36509648
68Recurrent viral infections (HP:0004429)2.36181641
69Abnormality of polysaccharide metabolism (HP:0011012)2.34880884
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34880884
71Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34880884
72Exertional dyspnea (HP:0002875)2.34356064
73Mucopolysacchariduria (HP:0008155)2.34333521
74Urinary glycosaminoglycan excretion (HP:0003541)2.34333521
75Arterial thrombosis (HP:0004420)2.33461461
76Epistaxis (HP:0000421)2.33360461
77Pulmonary infiltrates (HP:0002113)2.32861534
78Microvesicular hepatic steatosis (HP:0001414)2.31964921
79Neonatal short-limb short stature (HP:0008921)2.30954973
80Panhypogammaglobulinemia (HP:0003139)2.26441475
81Increased muscle lipid content (HP:0009058)2.24935721
82Lymphopenia (HP:0001888)2.24911082
83Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23814392
84Large eyes (HP:0001090)2.23557420
85Increased serum ferritin (HP:0003281)2.22685507
86Mediastinal lymphadenopathy (HP:0100721)2.22440869
87Poor head control (HP:0002421)2.21409456
8811 pairs of ribs (HP:0000878)2.19552741
89Breech presentation (HP:0001623)2.18541093
90Gingival bleeding (HP:0000225)2.18187983
91Sepsis (HP:0100806)2.18085682
92Neuronal loss in central nervous system (HP:0002529)2.16934382
93Abnormality of the vasculature of the conjunctiva (HP:0008054)2.16356913
94Abnormality of serine family amino acid metabolism (HP:0010894)2.16168416
95Abnormality of glycine metabolism (HP:0010895)2.16168416
96Prolonged neonatal jaundice (HP:0006579)2.15958356
97Mitochondrial inheritance (HP:0001427)2.15180948
98Leukocytosis (HP:0001974)2.14746154
99Sensorimotor neuropathy (HP:0007141)2.14462065
100Polycythemia (HP:0001901)2.13360088
101Congenital sensorineural hearing impairment (HP:0008527)2.13259364
102Abnormality of T cells (HP:0002843)2.12060992
103Hypoplastic ilia (HP:0000946)2.11434520
104Pulmonary embolism (HP:0002204)2.11378499
105Microcytic anemia (HP:0001935)2.10883342
106Hydroxyprolinuria (HP:0003080)2.10562764
107Abnormality of proline metabolism (HP:0010907)2.10562764
108Abnormality of T cell physiology (HP:0011840)2.10260367
109Petechiae (HP:0000967)2.07886539
110Abnormality of iron homeostasis (HP:0011031)2.07625057
111Orchitis (HP:0100796)2.07387357
112Type I transferrin isoform profile (HP:0003642)2.06565772
113Increased CSF lactate (HP:0002490)2.04392546
114Albinism (HP:0001022)2.04277611
115Colitis (HP:0002583)2.03766133
116Symphalangism affecting the phalanges of the hand (HP:0009773)2.03527301
117Increased serum lactate (HP:0002151)2.02252163
118Hypermelanotic macule (HP:0001034)2.01632823
119Abnormality of cells of the lymphoid lineage (HP:0012140)2.00876062
120Recurrent skin infections (HP:0001581)1.99631289
121Granulocytopenia (HP:0001913)1.98462040
122Progressive neurologic deterioration (HP:0002344)1.98214483
123Generalized aminoaciduria (HP:0002909)1.97646435
124T lymphocytopenia (HP:0005403)1.97127172
125Amyloidosis (HP:0011034)1.95131780
126Vertigo (HP:0002321)1.94993522
127Loss of speech (HP:0002371)1.94869551
128Cupped ribs (HP:0000887)1.94470843
129Abnormality of the pleura (HP:0002103)1.94420514
130Pustule (HP:0200039)1.92796894
131Hypertensive crisis (HP:0100735)1.92501471
132Pancreatitis (HP:0001733)1.92394431
133Increased hepatocellular lipid droplets (HP:0006565)1.92128784
134Glomerulopathy (HP:0100820)1.92085847
135Hypertriglyceridemia (HP:0002155)1.91858704
136Optic neuritis (HP:0100653)1.91214199
137Retrobulbar optic neuritis (HP:0100654)1.91214199
138Urticaria (HP:0001025)1.90149520
139Acne (HP:0001061)1.88542816
140Glomerulonephritis (HP:0000099)1.88180740
141Polygenic inheritance (HP:0010982)1.87588425
142Neoplasm of the rectum (HP:0100743)1.87581192
143IgM deficiency (HP:0002850)1.87408387
144Purpura (HP:0000979)1.87215470
145Skin ulcer (HP:0200042)1.86788129
146Generalized hypopigmentation (HP:0007513)1.86517291
147Increased CSF protein (HP:0002922)1.85761138
148Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85639606
149Abnormal protein N-linked glycosylation (HP:0012347)1.85639606
150Abnormal protein glycosylation (HP:0012346)1.85639606
151Abnormal glycosylation (HP:0012345)1.85639606
152Lactic acidosis (HP:0003128)1.84947629
153Acute encephalopathy (HP:0006846)1.84731313
154Irregular epiphyses (HP:0010582)1.84629120
155Segmental peripheral demyelination/remyelination (HP:0003481)1.83809672
156Anorexia (HP:0002039)1.83356326
157Abnormality of T cell number (HP:0011839)1.82462089
158Breast hypoplasia (HP:0003187)1.82276332
159Abnormal mitochondria in muscle tissue (HP:0008316)1.81893151
160Splenomegaly (HP:0001744)1.80789593
161Progressive visual loss (HP:0000529)1.80684462
162Aplasia/hypoplasia of the femur (HP:0005613)1.79218188
163Hypoplasia of the thymus (HP:0000778)1.77636983
164Methylmalonic acidemia (HP:0002912)1.75730895
165Gingivitis (HP:0000230)1.75487398
166True hermaphroditism (HP:0010459)1.75444006
167Acute hepatic failure (HP:0006554)1.74744342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK37.62519311
2BCKDK2.98717665
3BLK2.90777976
4MAP2K32.83714340
5MAP3K122.80597540
6FLT32.72196043
7TNK22.61403386
8TNIK2.44965818
9TGFBR22.42482227
10STK162.25791695
11PKN22.18158671
12CASK2.18127229
13IRAK42.15395168
14KIT2.11234715
15MAP3K142.07344111
16TSSK61.93826055
17TBK11.91578647
18SIK31.79506978
19BUB11.74433731
20MAP3K31.72837645
21TAOK11.71871354
22SMG11.70541764
23IRAK31.70165962
24GRK61.69460514
25FGR1.66000634
26SIK21.61226122
27LMTK21.59030099
28PRPF4B1.49493116
29KSR21.48887422
30CCNB11.47433292
31MAP3K11.46831675
32TAOK21.46776822
33EPHB21.44107054
34MAP4K11.41450677
35BTK1.34259543
36TYK21.32238097
37DAPK11.28008537
38NME21.24151243
39FES1.23579515
40ILK1.21640340
41PAK41.16530306
42JAK31.14791966
43SIK11.12845971
44ADRBK21.09928216
45TEC1.08204950
46YES11.05869596
47ERN11.05178295
48PDPK11.03839023
49ZAP701.03049001
50MYLK1.03008764
51IKBKE0.96242329
52CAMKK10.92390794
53PRKD20.90448503
54TXK0.89671758
55MARK20.89499555
56TESK20.88340553
57TLK10.88008548
58JAK10.87035394
59IRAK10.86635424
60MST1R0.86005725
61MAP3K50.83519864
62LYN0.83372355
63CSK0.82541488
64LCK0.81615162
65MATK0.81601556
66MAP2K40.80038730
67STK380.78948903
68PBK0.78197471
69PIM20.78151807
70MUSK0.74664258
71HIPK20.73884168
72IKBKB0.73543853
73MAP2K60.73280672
74CDK190.72863281
75RIPK10.72299715
76MAP3K110.72133246
77MAP3K60.71309152
78TGFBR10.70603525
79GRK70.68690308
80EPHA40.67237800
81SYK0.66756641
82MAP3K130.66018438
83RIPK40.65744090
84LRRK20.65497831
85NUAK10.65140790
86DYRK1B0.64626229
87MAP2K20.63872170
88FGFR40.62271118
89PAK60.62102895
90CSF1R0.61159758
91ALK0.60189815
92PIK3CG0.58761468
93NEK60.56717752
94ERBB20.55154482
95ERBB30.54643210
96FYN0.54245759
97STK100.52883131
98MAPK120.52605650
99MAPK70.52284580
100IRAK20.51952329
101RAF10.51309054
102DYRK20.50610465
103RET0.48605111
104BRAF0.46414869
105ACVR1B0.46384837
106PRKCZ0.46324842
107BMPR20.45669379
108DAPK30.45656289
109ARAF0.44830070
110PIK3CA0.43134162
111STK110.42802698
112CDC42BPA0.42370392
113EPHB10.42110004
114PASK0.41513256
115RPS6KL10.41401224
116RPS6KC10.41401224
117MAP3K70.41331134
118MARK30.41107790
119TRIB30.41016429
120PIM10.40481323
121MAP3K20.40091885
122KDR0.39731785
123PTK60.39318421
124PRKG20.38839683
125DAPK20.37794767
126MAPK40.36675753
127PAK10.36594849
128DYRK30.36139166
129JAK20.34170264
130PRKCD0.33944893
131PDK10.33913675
132MAP3K80.33654924
133CAMK40.32706544
134HCK0.31247147
135IGF1R0.31099968
136ITK0.31071845
137MAPKAPK20.30686804
138PRKD10.30674150
139SRC0.29541746
140ABL20.29095256
141RPS6KA20.29053225
142MST40.28412162
143MOS0.28379271
144VRK10.28063302
145FGFR10.27296593
146WEE10.25821803
147PRKCQ0.24229256

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.99612946
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.94341119
3Sulfur metabolism_Homo sapiens_hsa009202.53279820
4B cell receptor signaling pathway_Homo sapiens_hsa046622.19459897
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.15724866
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.13980699
7Acute myeloid leukemia_Homo sapiens_hsa052212.05766792
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97871833
9Lysosome_Homo sapiens_hsa041421.95787966
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.95525435
11Fatty acid elongation_Homo sapiens_hsa000621.88283821
12Folate biosynthesis_Homo sapiens_hsa007901.85630918
13Galactose metabolism_Homo sapiens_hsa000521.83063410
14Fatty acid degradation_Homo sapiens_hsa000711.80405177
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70757402
16Protein export_Homo sapiens_hsa030601.70273489
17Staphylococcus aureus infection_Homo sapiens_hsa051501.69263349
18Primary immunodeficiency_Homo sapiens_hsa053401.67880292
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64955252
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61813322
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.58239804
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57688011
23Chemokine signaling pathway_Homo sapiens_hsa040621.57598409
24Autoimmune thyroid disease_Homo sapiens_hsa053201.54706145
25Legionellosis_Homo sapiens_hsa051341.52875238
26Pentose phosphate pathway_Homo sapiens_hsa000301.52019031
27Peroxisome_Homo sapiens_hsa041461.51690815
28Proteasome_Homo sapiens_hsa030501.49108690
29RNA polymerase_Homo sapiens_hsa030201.48977435
30Leishmaniasis_Homo sapiens_hsa051401.48308553
31Hepatitis C_Homo sapiens_hsa051601.41889818
32Sulfur relay system_Homo sapiens_hsa041221.41390363
33Oxidative phosphorylation_Homo sapiens_hsa001901.38986058
34Shigellosis_Homo sapiens_hsa051311.37409413
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36716941
36Toxoplasmosis_Homo sapiens_hsa051451.36502903
37Fatty acid metabolism_Homo sapiens_hsa012121.35440567
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34367824
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33035654
40Carbon metabolism_Homo sapiens_hsa012001.32323243
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32172459
42Herpes simplex infection_Homo sapiens_hsa051681.31010299
43T cell receptor signaling pathway_Homo sapiens_hsa046601.29069630
44Mismatch repair_Homo sapiens_hsa034301.28603028
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.26547851
46Hepatitis B_Homo sapiens_hsa051611.26286941
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25413713
48DNA replication_Homo sapiens_hsa030301.23113251
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22292844
50Fructose and mannose metabolism_Homo sapiens_hsa000511.18192343
51Non-small cell lung cancer_Homo sapiens_hsa052231.17760581
52Pyruvate metabolism_Homo sapiens_hsa006201.17350541
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16863534
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16847227
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.16538841
56Rheumatoid arthritis_Homo sapiens_hsa053231.15072921
57Hematopoietic cell lineage_Homo sapiens_hsa046401.14564013
58VEGF signaling pathway_Homo sapiens_hsa043701.12472911
59Viral myocarditis_Homo sapiens_hsa054161.12423703
60Synaptic vesicle cycle_Homo sapiens_hsa047211.12285902
61Steroid biosynthesis_Homo sapiens_hsa001001.12148134
62Homologous recombination_Homo sapiens_hsa034401.11652958
63Jak-STAT signaling pathway_Homo sapiens_hsa046301.09248595
64Measles_Homo sapiens_hsa051621.08313213
65Pyrimidine metabolism_Homo sapiens_hsa002401.08279881
66Biosynthesis of amino acids_Homo sapiens_hsa012301.08066518
67Salmonella infection_Homo sapiens_hsa051321.07391245
68Apoptosis_Homo sapiens_hsa042101.07177752
69Chronic myeloid leukemia_Homo sapiens_hsa052201.06065954
70Endocytosis_Homo sapiens_hsa041441.05996769
71Sphingolipid signaling pathway_Homo sapiens_hsa040711.04625555
72African trypanosomiasis_Homo sapiens_hsa051431.03968891
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03814026
74Cyanoamino acid metabolism_Homo sapiens_hsa004601.03570813
75Sphingolipid metabolism_Homo sapiens_hsa006001.03420159
76Propanoate metabolism_Homo sapiens_hsa006401.02988409
77ABC transporters_Homo sapiens_hsa020101.00585439
78Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00094147
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99894661
80Osteoclast differentiation_Homo sapiens_hsa043800.98319556
81Arginine and proline metabolism_Homo sapiens_hsa003300.97338921
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.95263248
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94780700
84Vitamin digestion and absorption_Homo sapiens_hsa049770.94608086
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93652815
86Pertussis_Homo sapiens_hsa051330.93015467
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92764198
88Type I diabetes mellitus_Homo sapiens_hsa049400.92241777
89Collecting duct acid secretion_Homo sapiens_hsa049660.92105459
90Epstein-Barr virus infection_Homo sapiens_hsa051690.91800008
91Histidine metabolism_Homo sapiens_hsa003400.90762599
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.88096242
93Pancreatic cancer_Homo sapiens_hsa052120.86763908
94Vibrio cholerae infection_Homo sapiens_hsa051100.85992418
95Phagosome_Homo sapiens_hsa041450.85914063
96Prolactin signaling pathway_Homo sapiens_hsa049170.85238938
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.84667986
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.84553941
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.84415003
100Ribosome_Homo sapiens_hsa030100.84094814
101Allograft rejection_Homo sapiens_hsa053300.83597324
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83543172
103PPAR signaling pathway_Homo sapiens_hsa033200.82819438
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82745805
105Malaria_Homo sapiens_hsa051440.82702295
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.82393385
107Influenza A_Homo sapiens_hsa051640.81373281
108HIF-1 signaling pathway_Homo sapiens_hsa040660.81264368
109Platelet activation_Homo sapiens_hsa046110.81253969
110Regulation of autophagy_Homo sapiens_hsa041400.81229544
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81223279
112Notch signaling pathway_Homo sapiens_hsa043300.80219696
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79902371
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79163836
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78893620
116mTOR signaling pathway_Homo sapiens_hsa041500.78335865
117TNF signaling pathway_Homo sapiens_hsa046680.78119725
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77430231
119Inositol phosphate metabolism_Homo sapiens_hsa005620.75704777
120Renin-angiotensin system_Homo sapiens_hsa046140.74829385
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74528882
122Prion diseases_Homo sapiens_hsa050200.74311191
123Tuberculosis_Homo sapiens_hsa051520.73710241
124Antigen processing and presentation_Homo sapiens_hsa046120.72983662
125Fatty acid biosynthesis_Homo sapiens_hsa000610.72391331
126Parkinsons disease_Homo sapiens_hsa050120.70696140
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70688380
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.70681703
129GnRH signaling pathway_Homo sapiens_hsa049120.69681544
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.67573851
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.67185608
132Graft-versus-host disease_Homo sapiens_hsa053320.66908158
133Renal cell carcinoma_Homo sapiens_hsa052110.65956250
134Selenocompound metabolism_Homo sapiens_hsa004500.65452195
135Viral carcinogenesis_Homo sapiens_hsa052030.65175123
136Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64832976
137* Metabolic pathways_Homo sapiens_hsa011000.64414359
138Purine metabolism_Homo sapiens_hsa002300.64314429
139Glycerolipid metabolism_Homo sapiens_hsa005610.64202381
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63370804
141Mineral absorption_Homo sapiens_hsa049780.62417482
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62281813
143Base excision repair_Homo sapiens_hsa034100.61286185
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61144685
145ErbB signaling pathway_Homo sapiens_hsa040120.58665038
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58580663
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57139789
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56799686
149N-Glycan biosynthesis_Homo sapiens_hsa005100.56725645
150Endometrial cancer_Homo sapiens_hsa052130.56691585
151Type II diabetes mellitus_Homo sapiens_hsa049300.56634814
152Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56451838
153Estrogen signaling pathway_Homo sapiens_hsa049150.56414369
154Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56061002
155Choline metabolism in cancer_Homo sapiens_hsa052310.54196860
156Fat digestion and absorption_Homo sapiens_hsa049750.54134538
157Insulin signaling pathway_Homo sapiens_hsa049100.53782217
158Glutathione metabolism_Homo sapiens_hsa004800.53760126
159Long-term potentiation_Homo sapiens_hsa047200.52899139
160FoxO signaling pathway_Homo sapiens_hsa040680.52447962
161Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52166766
162AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48618356
163Central carbon metabolism in cancer_Homo sapiens_hsa052300.47373614
164HTLV-I infection_Homo sapiens_hsa051660.46534364
165Insulin resistance_Homo sapiens_hsa049310.44516721
166MAPK signaling pathway_Homo sapiens_hsa040100.44233422

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