PIP5KL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.41979699
2neuron cell-cell adhesion (GO:0007158)5.40177995
3vocalization behavior (GO:0071625)5.33472548
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.23327355
5behavioral response to nicotine (GO:0035095)5.19946376
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.01642158
7glutamate secretion (GO:0014047)4.88671952
8neurotransmitter secretion (GO:0007269)4.78914233
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.60613337
10regulation of glutamate receptor signaling pathway (GO:1900449)4.54383620
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.40481961
12regulation of synaptic vesicle exocytosis (GO:2000300)4.40122335
13neuronal action potential propagation (GO:0019227)4.39804691
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.31587585
15ATP hydrolysis coupled proton transport (GO:0015991)4.28432536
16energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.28432536
17dopamine transport (GO:0015872)4.27990855
18synaptic vesicle maturation (GO:0016188)4.26773445
19protein localization to synapse (GO:0035418)4.22047831
20pyrimidine nucleobase catabolic process (GO:0006208)4.18693126
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.17422188
22locomotory exploration behavior (GO:0035641)4.14300249
23neuron-neuron synaptic transmission (GO:0007270)4.05478752
24neurotransmitter transport (GO:0006836)3.93955053
25regulation of synaptic vesicle transport (GO:1902803)3.92229973
26cornea development in camera-type eye (GO:0061303)3.89185174
27presynaptic membrane assembly (GO:0097105)3.83450858
28neurotransmitter-gated ion channel clustering (GO:0072578)3.78327985
29water-soluble vitamin biosynthetic process (GO:0042364)3.77502408
30regulation of neurotransmitter levels (GO:0001505)3.77474611
31exploration behavior (GO:0035640)3.75314681
32positive regulation of synapse maturation (GO:0090129)3.75170490
33proline transport (GO:0015824)3.72623219
34synaptic vesicle endocytosis (GO:0048488)3.71155278
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71089823
36response to histamine (GO:0034776)3.69265524
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.66430766
38nucleobase catabolic process (GO:0046113)3.65248984
39transferrin transport (GO:0033572)3.65203555
40cell migration in hindbrain (GO:0021535)3.60605585
41presynaptic membrane organization (GO:0097090)3.60344913
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.59123813
43neuron recognition (GO:0008038)3.56755311
44catecholamine transport (GO:0051937)3.55507914
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.54442415
46synaptic transmission, glutamatergic (GO:0035249)3.53931020
47postsynaptic membrane organization (GO:0001941)3.52400684
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.51811838
49negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.51691883
50calcium ion-dependent exocytosis (GO:0017156)3.49178773
51regulation of protein kinase A signaling (GO:0010738)3.45285883
52positive regulation of synapse assembly (GO:0051965)3.44785853
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43649275
54negative regulation of microtubule polymerization (GO:0031115)3.42133267
55ATP synthesis coupled proton transport (GO:0015986)3.41591984
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.41591984
57glutamate receptor signaling pathway (GO:0007215)3.41340441
58gamma-aminobutyric acid transport (GO:0015812)3.39598854
59cerebellar Purkinje cell differentiation (GO:0021702)3.37195920
60ferric iron transport (GO:0015682)3.36018776
61trivalent inorganic cation transport (GO:0072512)3.36018776
62cerebellar granule cell differentiation (GO:0021707)3.35254315
63neuromuscular process controlling posture (GO:0050884)3.31605200
64regulation of neuronal synaptic plasticity (GO:0048168)3.30115205
65response to pheromone (GO:0019236)3.29010275
66membrane depolarization during action potential (GO:0086010)3.28654649
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.27951515
68long-term synaptic potentiation (GO:0060291)3.26862418
69negative regulation of dendrite morphogenesis (GO:0050774)3.23203967
70regulation of synapse structural plasticity (GO:0051823)3.23196615
71synaptic transmission, dopaminergic (GO:0001963)3.22692812
72layer formation in cerebral cortex (GO:0021819)3.22493113
73regulation of long-term neuronal synaptic plasticity (GO:0048169)3.21322889
74L-fucose catabolic process (GO:0042355)3.20767194
75fucose catabolic process (GO:0019317)3.20767194
76L-fucose metabolic process (GO:0042354)3.20767194
77detection of light stimulus involved in sensory perception (GO:0050962)3.20014891
78detection of light stimulus involved in visual perception (GO:0050908)3.20014891
79negative regulation of telomere maintenance (GO:0032205)3.19414795
80prepulse inhibition (GO:0060134)3.18213202
81piRNA metabolic process (GO:0034587)3.17548108
82striatum development (GO:0021756)3.17250229
83protein polyglutamylation (GO:0018095)3.17087106
84synapse assembly (GO:0007416)3.16997124
85neurotransmitter biosynthetic process (GO:0042136)3.15528746
86protein complex biogenesis (GO:0070271)3.14979844
87behavioral response to cocaine (GO:0048148)3.13865530
88preassembly of GPI anchor in ER membrane (GO:0016254)3.13616814
89protein localization to cilium (GO:0061512)3.12422229
90startle response (GO:0001964)3.12334298
91regulation of excitatory postsynaptic membrane potential (GO:0060079)3.11257550
92transmission of nerve impulse (GO:0019226)3.11089117
93intraciliary transport (GO:0042073)3.09453407
94regulation of synapse maturation (GO:0090128)3.09335863
95innervation (GO:0060384)3.09296193
96neuromuscular synaptic transmission (GO:0007274)3.08764882
97positive regulation of mitochondrial fission (GO:0090141)3.07509184
98regulation of postsynaptic membrane potential (GO:0060078)3.07261994
99establishment of synaptic vesicle localization (GO:0097480)3.07195097
100synaptic vesicle transport (GO:0048489)3.07195097
101nonmotile primary cilium assembly (GO:0035058)3.07055473
102membrane hyperpolarization (GO:0060081)3.04910906
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04393897
104mating behavior (GO:0007617)3.04069386
105protein-cofactor linkage (GO:0018065)3.02402195
106mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02263772
107positive regulation of membrane potential (GO:0045838)3.01247385
108epithelial cilium movement (GO:0003351)2.99643799
109membrane depolarization (GO:0051899)2.99390586
110long-term memory (GO:0007616)2.98894860
111axonal fasciculation (GO:0007413)2.96065272
112neurotransmitter uptake (GO:0001504)2.95812287
113dopamine biosynthetic process (GO:0042416)2.94569021
114auditory behavior (GO:0031223)2.93398072
115synaptic transmission, cholinergic (GO:0007271)2.93207617
116mechanosensory behavior (GO:0007638)2.92763250
117mannosylation (GO:0097502)2.92343389
118regulation of neurotransmitter secretion (GO:0046928)2.92304704
119photoreceptor cell development (GO:0042461)2.92002555
120synaptic transmission (GO:0007268)2.91495224
121dendrite development (GO:0016358)2.91065812
122regulation of cilium movement (GO:0003352)2.89743566
123regulation of vesicle fusion (GO:0031338)2.88239916
124regulation of dopamine metabolic process (GO:0042053)2.87506358
125regulation of catecholamine metabolic process (GO:0042069)2.87506358
126axoneme assembly (GO:0035082)2.87283212
127mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86895276
128mitochondrial respiratory chain complex I assembly (GO:0032981)2.86895276
129NADH dehydrogenase complex assembly (GO:0010257)2.86895276
130regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.86339493
131epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85275375
132mitochondrial respiratory chain complex assembly (GO:0033108)2.83657043
133retinal cone cell development (GO:0046549)2.83496619
134respiratory chain complex IV assembly (GO:0008535)2.82377633
135platelet dense granule organization (GO:0060155)2.76048126
136spinal cord motor neuron differentiation (GO:0021522)2.75797845
137detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.75501745
138peptidyl-histidine modification (GO:0018202)2.73056769
139somite development (GO:0061053)2.72978671
140cilium morphogenesis (GO:0060271)2.70824397
141RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.70327543
142tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.70327543
143negative regulation of transcription regulatory region DNA binding (GO:2000678)2.70130066
144GPI anchor metabolic process (GO:0006505)2.69766219
145regulation of feeding behavior (GO:0060259)2.69698254
146DNA double-strand break processing (GO:0000729)2.68993143
147cytochrome complex assembly (GO:0017004)2.66180139
148iron-sulfur cluster assembly (GO:0016226)2.63401223
149metallo-sulfur cluster assembly (GO:0031163)2.63401223
150DNA methylation involved in gamete generation (GO:0043046)2.62517442
151eye photoreceptor cell development (GO:0042462)2.60355850
152inositol phosphate catabolic process (GO:0071545)2.59043919
153protein neddylation (GO:0045116)2.58607170
154nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.58431518
155behavioral response to ethanol (GO:0048149)2.56239226
156DNA deamination (GO:0045006)2.55236813
157G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54303494
158regulation of telomere maintenance (GO:0032204)2.53135411
159short-term memory (GO:0007614)2.53036095
160exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.52980202
161cilium organization (GO:0044782)2.52148761
162cell differentiation in spinal cord (GO:0021515)2.51147049
163cilium assembly (GO:0042384)2.47736386
164nephron tubule morphogenesis (GO:0072078)2.46986101
165nephron epithelium morphogenesis (GO:0072088)2.46986101
166neural tube formation (GO:0001841)2.46788238
167regulation of glucokinase activity (GO:0033131)2.46458971
168regulation of hexokinase activity (GO:1903299)2.46458971
169regulation of rhodopsin mediated signaling pathway (GO:0022400)2.46103461
170neuronal action potential (GO:0019228)2.45222542
171meiotic chromosome segregation (GO:0045132)2.43665305
172regulation of nuclear cell cycle DNA replication (GO:0033262)2.42844017
173hindbrain development (GO:0030902)2.42507671
174L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.42423960
175regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.40945627
176cilium movement (GO:0003341)2.40685417
177base-excision repair, AP site formation (GO:0006285)2.39908757
178regulation of timing of cell differentiation (GO:0048505)2.39848375
179tRNA processing (GO:0008033)2.39548997
180somatic diversification of immune receptors via somatic mutation (GO:0002566)2.38995646
181somatic hypermutation of immunoglobulin genes (GO:0016446)2.38995646
182rhodopsin mediated signaling pathway (GO:0016056)2.34736740
183regulation of development, heterochronic (GO:0040034)2.34385715
184keratinocyte development (GO:0003334)2.33711882
185regulation of action potential (GO:0098900)2.33539745
186neuron fate determination (GO:0048664)2.33012040
187recombinational repair (GO:0000725)2.32946377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.36203907
2GBX2_23144817_ChIP-Seq_PC3_Human4.04028796
3HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00196183
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.99698571
5REST_21632747_ChIP-Seq_MESCs_Mouse2.89167109
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.88845318
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83499280
8TAF15_26573619_Chip-Seq_HEK293_Human2.79611379
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.72420254
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70653314
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69766941
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.54384092
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51287294
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.39533564
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.34345840
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31626856
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31042572
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30586918
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.28442739
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22513669
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21788754
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21788754
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20448244
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16823828
25VDR_22108803_ChIP-Seq_LS180_Human2.16211803
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12669935
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09102253
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09064616
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07706911
30IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07396276
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04840249
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.98802827
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.96439147
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.94732315
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91335931
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91162264
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.87582393
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85540245
39ZNF274_21170338_ChIP-Seq_K562_Hela1.85328149
40EWS_26573619_Chip-Seq_HEK293_Human1.83645672
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.83585674
42DROSHA_22980978_ChIP-Seq_HELA_Human1.81711530
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.80179698
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80074425
45TP53_22573176_ChIP-Seq_HFKS_Human1.78849395
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78637771
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76780422
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.71608068
49MYC_18940864_ChIP-ChIP_HL60_Human1.71039198
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68898678
51SMAD4_21799915_ChIP-Seq_A2780_Human1.68364759
52IRF1_19129219_ChIP-ChIP_H3396_Human1.63755363
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61694680
54FUS_26573619_Chip-Seq_HEK293_Human1.58388092
55P300_19829295_ChIP-Seq_ESCs_Human1.55217475
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.54071566
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.54064633
58VDR_23849224_ChIP-Seq_CD4+_Human1.53847320
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.53638857
60IGF1R_20145208_ChIP-Seq_DFB_Human1.52248415
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.47417724
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43659721
63AR_21572438_ChIP-Seq_LNCaP_Human1.43118707
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.42600718
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40396571
66RNF2_27304074_Chip-Seq_NSC_Mouse1.39592923
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39549264
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38291002
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36961075
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36488272
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36095761
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34733698
73ELK1_19687146_ChIP-ChIP_HELA_Human1.33896386
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29264742
75AR_25329375_ChIP-Seq_VCAP_Human1.28106672
76NCOR_22424771_ChIP-Seq_293T_Human1.28056365
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.25549061
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24507603
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23243538
80CBP_20019798_ChIP-Seq_JUKART_Human1.23243538
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21832241
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.21756664
83GABP_19822575_ChIP-Seq_HepG2_Human1.21376133
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21368835
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19223814
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18093007
87ER_23166858_ChIP-Seq_MCF-7_Human1.17926126
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16611602
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16458644
90FOXP3_21729870_ChIP-Seq_TREG_Human1.15897611
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15479468
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15457285
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15383561
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15303065
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15239761
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14782456
97ERA_21632823_ChIP-Seq_H3396_Human1.13424613
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.10835805
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.10749678
100SOX9_26525672_Chip-Seq_HEART_Mouse1.09321638
101JUN_21703547_ChIP-Seq_K562_Human1.09268862
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08773569
103AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08465919
104STAT3_23295773_ChIP-Seq_U87_Human1.07829506
105* NANOG_20526341_ChIP-Seq_ESCs_Human1.06825892
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05806815
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.05806815
108ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05643634
109MYC_19829295_ChIP-Seq_ESCs_Human1.05631797
110TCF4_23295773_ChIP-Seq_U87_Human1.05148508
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04956243
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04779712
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04541791
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03185745
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03184072
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.02404593
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02129920
118YY1_21170310_ChIP-Seq_MESCs_Mouse1.01982702
119HOXB7_26014856_ChIP-Seq_BT474_Human1.01921514
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01581949
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01381792
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99873502
123NANOG_19829295_ChIP-Seq_ESCs_Human0.99408459
124SOX2_19829295_ChIP-Seq_ESCs_Human0.99408459
125CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99339312
126CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99335326
127RUNX2_22187159_ChIP-Seq_PCA_Human0.98563916
128* SMAD3_21741376_ChIP-Seq_ESCs_Human0.98222058
129PRDM14_20953172_ChIP-Seq_ESCs_Human0.97961650
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.97578249
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96191561
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95869317
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94755893
134* AR_20517297_ChIP-Seq_VCAP_Human0.94695205
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94430672
136P53_21459846_ChIP-Seq_SAOS-2_Human0.93335669
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92860691
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92860691
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92695692
140AR_19668381_ChIP-Seq_PC3_Human0.92664655
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90934065
142EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90843340
143ERG_21242973_ChIP-ChIP_JURKAT_Human0.90241135
144SOX2_16153702_ChIP-ChIP_HESCs_Human0.89679261
145THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89670492
146KDM2B_26808549_Chip-Seq_REH_Human0.89618429
147P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88875962
148AHR_22903824_ChIP-Seq_MCF-7_Human0.87087408
149GATA1_26923725_Chip-Seq_HPCs_Mouse0.84257972
150* ARNT_22903824_ChIP-Seq_MCF-7_Human0.83140296
151BCAT_22108803_ChIP-Seq_LS180_Human0.81759970
152POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.81643002
153SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81622327
154* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81400452
155EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81174727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.14982278
2MP0004859_abnormal_synaptic_plasticity4.40386599
3MP0003635_abnormal_synaptic_transmissio3.68108985
4MP0006292_abnormal_olfactory_placode3.62697345
5MP0009046_muscle_twitch3.31979647
6MP0002064_seizures3.07919039
7MP0009745_abnormal_behavioral_response3.07554044
8MP0004270_analgesia3.07395345
9MP0005423_abnormal_somatic_nervous2.94376385
10MP0002063_abnormal_learning/memory/cond2.92010384
11MP0001529_abnormal_vocalization2.78685599
12MP0002572_abnormal_emotion/affect_behav2.76106351
13MP0001968_abnormal_touch/_nociception2.72418077
14MP0002272_abnormal_nervous_system2.55629092
15MP0006276_abnormal_autonomic_nervous2.54919484
16MP0002734_abnormal_mechanical_nocicepti2.53358288
17MP0002735_abnormal_chemical_nociception2.47571747
18MP0001486_abnormal_startle_reflex2.39961509
19MP0003195_calcinosis2.38787623
20MP0002638_abnormal_pupillary_reflex2.36003117
21MP0002736_abnormal_nociception_after2.32000021
22MP0001501_abnormal_sleep_pattern2.31732660
23MP0002102_abnormal_ear_morphology2.24819598
24MP0001905_abnormal_dopamine_level2.16908293
25MP0003122_maternal_imprinting2.15235416
26MP0002822_catalepsy2.11459404
27MP0008789_abnormal_olfactory_epithelium2.10485742
28MP0001440_abnormal_grooming_behavior2.06502191
29MP0002067_abnormal_sensory_capabilities2.05396024
30MP0005410_abnormal_fertilization2.03607553
31MP0002733_abnormal_thermal_nociception2.02311637
32MP0002184_abnormal_innervation2.00415484
33MP0004142_abnormal_muscle_tone1.96677242
34MP0004924_abnormal_behavior1.87131391
35MP0005386_behavior/neurological_phenoty1.87131391
36MP0000372_irregular_coat_pigmentation1.85254411
37MP0002938_white_spotting1.84194763
38MP0000778_abnormal_nervous_system1.84007104
39MP0001970_abnormal_pain_threshold1.78692504
40MP0001984_abnormal_olfaction1.76414678
41MP0002557_abnormal_social/conspecific_i1.73366367
42MP0004147_increased_porphyrin_level1.73249797
43MP0004811_abnormal_neuron_physiology1.68742346
44MP0008058_abnormal_DNA_repair1.68629006
45MP0003011_delayed_dark_adaptation1.68258889
46MP0003787_abnormal_imprinting1.66244328
47MP0001188_hyperpigmentation1.64001215
48MP0003136_yellow_coat_color1.61269826
49MP0000955_abnormal_spinal_cord1.59458958
50MP0004133_heterotaxia1.57947522
51MP0004858_abnormal_nervous_system1.54386750
52MP0003329_amyloid_beta_deposits1.51281685
53MP0005084_abnormal_gallbladder_morpholo1.49581796
54MP0008569_lethality_at_weaning1.46741812
55MP0002066_abnormal_motor_capabilities/c1.44206875
56MP0002837_dystrophic_cardiac_calcinosis1.44197942
57MP0005646_abnormal_pituitary_gland1.43418929
58MP0002234_abnormal_pharynx_morphology1.41363177
59MP0000427_abnormal_hair_cycle1.40908703
60MP0002882_abnormal_neuron_morphology1.39856441
61MP0003879_abnormal_hair_cell1.38969752
62MP0004043_abnormal_pH_regulation1.36471879
63MP0002160_abnormal_reproductive_system1.29022380
64MP0008872_abnormal_physiological_respon1.28490624
65MP0002163_abnormal_gland_morphology1.27869156
66MP0008875_abnormal_xenobiotic_pharmacok1.24856592
67MP0002332_abnormal_exercise_endurance1.20770407
68MP0004233_abnormal_muscle_weight1.20020657
69MP0002909_abnormal_adrenal_gland1.16681890
70MP0009780_abnormal_chondrocyte_physiolo1.14810909
71MP0008877_abnormal_DNA_methylation1.13786125
72MP0008995_early_reproductive_senescence1.13268324
73MP0002152_abnormal_brain_morphology1.11241160
74MP0005195_abnormal_posterior_eye1.10101917
75MP0001919_abnormal_reproductive_system1.08880479
76MP0005499_abnormal_olfactory_system1.07979920
77MP0005394_taste/olfaction_phenotype1.07979920
78MP0005377_hearing/vestibular/ear_phenot1.07258669
79MP0003878_abnormal_ear_physiology1.07258669
80MP0000049_abnormal_middle_ear1.06506928
81MP0003119_abnormal_digestive_system1.04736888
82MP0005083_abnormal_biliary_tract1.03121640
83MP0000751_myopathy1.02696982
84MP0005389_reproductive_system_phenotype1.01453729
85MP0005551_abnormal_eye_electrophysiolog1.01089959
86MP0003121_genomic_imprinting1.00629840
87MP0003646_muscle_fatigue1.00430209
88MP0000026_abnormal_inner_ear1.00300286
89MP0001502_abnormal_circadian_rhythm0.99185131
90MP0002229_neurodegeneration0.98733411
91MP0001485_abnormal_pinna_reflex0.97873866
92MP0004742_abnormal_vestibular_system0.97787690
93MP0003631_nervous_system_phenotype0.96604774
94MP0005645_abnormal_hypothalamus_physiol0.96548389
95MP0003698_abnormal_male_reproductive0.96538795
96MP0002928_abnormal_bile_duct0.95840377
97MP0003633_abnormal_nervous_system0.95331426
98MP0004145_abnormal_muscle_electrophysio0.92870842
99MP0003123_paternal_imprinting0.92357446
100MP0003786_premature_aging0.92303774
101MP0002653_abnormal_ependyma_morphology0.91804551
102MP0005174_abnormal_tail_pigmentation0.91281913
103MP0002752_abnormal_somatic_nervous0.91179615
104MP0001293_anophthalmia0.90649329
105MP0003718_maternal_effect0.88311784
106MP0005253_abnormal_eye_physiology0.88119300
107MP0002210_abnormal_sex_determination0.87122381
108MP0002876_abnormal_thyroid_physiology0.86879719
109MP0003938_abnormal_ear_development0.86704340
110MP0000566_synostosis0.86544570
111MP0001963_abnormal_hearing_physiology0.85866334
112MP0005535_abnormal_body_temperature0.85616995
113MP0003937_abnormal_limbs/digits/tail_de0.85593834
114MP0000569_abnormal_digit_pigmentation0.84075105
115MP0005332_abnormal_amino_acid0.83617432
116MP0002069_abnormal_eating/drinking_beha0.81944303
117MP0001324_abnormal_eye_pigmentation0.81865373
118MP0006035_abnormal_mitochondrial_morpho0.81790988
119MP0001986_abnormal_taste_sensitivity0.81708243
120MP0003183_abnormal_peptide_metabolism0.80275421
121MP0006072_abnormal_retinal_apoptosis0.78929745
122MP0003632_abnormal_nervous_system0.78624351
123MP0001664_abnormal_digestion0.77902061
124MP0000631_abnormal_neuroendocrine_gland0.77671858
125MP0005171_absent_coat_pigmentation0.77485471
126MP0003634_abnormal_glial_cell0.74468579
127MP0004885_abnormal_endolymph0.72338379
128MP0001943_abnormal_respiration0.72298868
129MP0004085_abnormal_heartbeat0.72114521
130MP0003861_abnormal_nervous_system0.70837559
131MP0005623_abnormal_meninges_morphology0.69048639
132MP0004215_abnormal_myocardial_fiber0.68000395
133MP0008874_decreased_physiological_sensi0.67525841
134MP0002697_abnormal_eye_size0.65804139
135MP0001299_abnormal_eye_distance/0.64391786
136MP0001348_abnormal_lacrimal_gland0.63234910
137MP0002090_abnormal_vision0.62746194
138MP0010770_preweaning_lethality0.62543960
139MP0002082_postnatal_lethality0.62543960
140MP0002751_abnormal_autonomic_nervous0.61930661
141MP0004036_abnormal_muscle_relaxation0.61280400

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.38292238
2Nuclear cataract (HP:0100018)5.74481914
3Zonular cataract (HP:0010920)5.34397900
4Atonic seizures (HP:0010819)5.27492124
5Myokymia (HP:0002411)5.21449994
6Focal seizures (HP:0007359)4.82034857
7Epileptic encephalopathy (HP:0200134)4.74061169
8Febrile seizures (HP:0002373)4.47446997
9Limb dystonia (HP:0002451)4.30151372
10Visual hallucinations (HP:0002367)4.13449721
11Amblyopia (HP:0000646)4.12466930
12Absence seizures (HP:0002121)4.03706056
13Progressive cerebellar ataxia (HP:0002073)3.79519668
14Dialeptic seizures (HP:0011146)3.74503902
15Congenital stationary night blindness (HP:0007642)3.71272806
16Type II lissencephaly (HP:0007260)3.53816303
17Nephronophthisis (HP:0000090)3.50418879
18Pancreatic cysts (HP:0001737)3.48903190
19Poor suck (HP:0002033)3.39502165
20Hyperventilation (HP:0002883)3.38933497
21Pancreatic fibrosis (HP:0100732)3.19828188
22Pheochromocytoma (HP:0002666)3.19710378
23Abnormality of midbrain morphology (HP:0002418)3.19515625
24Molar tooth sign on MRI (HP:0002419)3.19515625
25Generalized tonic-clonic seizures (HP:0002069)3.17661615
26Acute necrotizing encephalopathy (HP:0006965)3.12234577
27Neuroendocrine neoplasm (HP:0100634)3.11786237
28True hermaphroditism (HP:0010459)3.06665887
29Abnormal mitochondria in muscle tissue (HP:0008316)3.00654599
30Failure to thrive in infancy (HP:0001531)3.00268997
31Polyphagia (HP:0002591)2.99730303
32Abnormality of the renal medulla (HP:0100957)2.87509136
33Absent/shortened dynein arms (HP:0200106)2.87483881
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.87483881
35Abnormal hair whorl (HP:0010721)2.83659353
36Action tremor (HP:0002345)2.80957277
37Lissencephaly (HP:0001339)2.80944635
38Insidious onset (HP:0003587)2.78024364
39Termporal pattern (HP:0011008)2.78024364
40Abnormality of the labia minora (HP:0012880)2.73815138
41Abnormality of the corticospinal tract (HP:0002492)2.71352131
42Progressive macrocephaly (HP:0004481)2.67668376
43Supranuclear gaze palsy (HP:0000605)2.66828460
44Nephrogenic diabetes insipidus (HP:0009806)2.64379255
45Impaired vibration sensation in the lower limbs (HP:0002166)2.62688566
46Poor eye contact (HP:0000817)2.61959186
47Broad-based gait (HP:0002136)2.60731144
48Attenuation of retinal blood vessels (HP:0007843)2.60398991
49Fetal akinesia sequence (HP:0001989)2.58294293
50Ankle clonus (HP:0011448)2.55044685
51Abnormal eating behavior (HP:0100738)2.54427691
52Abnormality of the renal cortex (HP:0011035)2.52439230
53Pendular nystagmus (HP:0012043)2.52364604
54Mitochondrial inheritance (HP:0001427)2.52099022
55Spastic gait (HP:0002064)2.51657147
56Progressive inability to walk (HP:0002505)2.48194569
57Cerebellar dysplasia (HP:0007033)2.47007130
58Chronic hepatic failure (HP:0100626)2.45477632
59Truncal ataxia (HP:0002078)2.43717886
60Resting tremor (HP:0002322)2.43376650
61Retinal dysplasia (HP:0007973)2.41883743
62Bradykinesia (HP:0002067)2.41432060
63Gaze-evoked nystagmus (HP:0000640)2.40489961
64Abnormal social behavior (HP:0012433)2.40189982
65Impaired social interactions (HP:0000735)2.40189982
66Polydipsia (HP:0001959)2.40001338
67Abnormal drinking behavior (HP:0030082)2.40001338
68Hypoplasia of the fovea (HP:0007750)2.39795649
69Aplasia/Hypoplasia of the fovea (HP:0008060)2.39795649
70Acute encephalopathy (HP:0006846)2.35347643
71Sclerocornea (HP:0000647)2.35157070
72Generalized hypotonia (HP:0001290)2.34663150
73Morphological abnormality of the pyramidal tract (HP:0002062)2.34143672
74Pachygyria (HP:0001302)2.31940537
75Urinary urgency (HP:0000012)2.31468486
76Patellar aplasia (HP:0006443)2.31435546
77Drooling (HP:0002307)2.30516621
78Excessive salivation (HP:0003781)2.30516621
79Degeneration of the lateral corticospinal tracts (HP:0002314)2.29826043
80Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.29826043
81Congenital primary aphakia (HP:0007707)2.29505473
82Abnormality of the lower motor neuron (HP:0002366)2.29159774
83Hypoplasia of the pons (HP:0012110)2.28275722
84Tubular atrophy (HP:0000092)2.28136252
85Aplasia/Hypoplasia of the patella (HP:0006498)2.27687361
86Abnormality of glycolysis (HP:0004366)2.26303442
87Increased serum pyruvate (HP:0003542)2.26303442
88Abnormal rod and cone electroretinograms (HP:0008323)2.26018237
89Abnormality of binocular vision (HP:0011514)2.25935923
90Diplopia (HP:0000651)2.25935923
91Vaginal atresia (HP:0000148)2.25780907
92Hypoventilation (HP:0002791)2.25196880
93Abnormality of the pons (HP:0007361)2.23954412
94Gait imbalance (HP:0002141)2.23739999
95Depression (HP:0000716)2.23275999
96Genital tract atresia (HP:0001827)2.22169534
97Abnormality of the fovea (HP:0000493)2.22133563
98Colon cancer (HP:0003003)2.21863644
99Postural instability (HP:0002172)2.21583175
100Optic nerve hypoplasia (HP:0000609)2.20983798
101Anxiety (HP:0000739)2.20884419
102Urinary bladder sphincter dysfunction (HP:0002839)2.20592093
103Rib fusion (HP:0000902)2.19889268
104Abolished electroretinogram (ERG) (HP:0000550)2.18228108
105Akinesia (HP:0002304)2.16824260
106Postural tremor (HP:0002174)2.14165660
107Cholecystitis (HP:0001082)2.13705148
108Abnormal gallbladder physiology (HP:0012438)2.13705148
109Delusions (HP:0000746)2.13401628
110Increased CSF lactate (HP:0002490)2.12437780
111Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12371268
112Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.12006256
113Neoplasm of the peripheral nervous system (HP:0100007)2.11929802
114Methylmalonic acidemia (HP:0002912)2.10582352
115Mutism (HP:0002300)2.08249706
116Epileptiform EEG discharges (HP:0011182)2.08100822
117Specific learning disability (HP:0001328)2.06813101
118Methylmalonic aciduria (HP:0012120)2.06431480
119Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06281160
1203-Methylglutaconic aciduria (HP:0003535)2.05641511
121Bony spicule pigmentary retinopathy (HP:0007737)2.04200718
122Renal cortical cysts (HP:0000803)2.03978998
123Inability to walk (HP:0002540)2.03748956
124Impaired smooth pursuit (HP:0007772)2.03009206
125Polyuria (HP:0000103)2.02730818
126Dysdiadochokinesis (HP:0002075)2.02147636
127Delayed gross motor development (HP:0002194)2.01641640
128EEG with generalized epileptiform discharges (HP:0011198)1.99822458
129Cystic liver disease (HP:0006706)1.99380114
130Hepatocellular necrosis (HP:0001404)1.98453502
131Bilateral microphthalmos (HP:0007633)1.98448323
132Ulnar claw (HP:0001178)1.98413236
133Absent thumb (HP:0009777)1.97940999
134Dysmetria (HP:0001310)1.97538372
135Cerebral inclusion bodies (HP:0100314)1.97026793
136Optic disc pallor (HP:0000543)1.96555268
137Abnormality of the vocal cords (HP:0008777)1.95546250
138Severe muscular hypotonia (HP:0006829)1.95308052
139Tachypnea (HP:0002789)1.95049405
140Hemiparesis (HP:0001269)1.94416072
141Agitation (HP:0000713)1.93711816
142Congenital hepatic fibrosis (HP:0002612)1.93473119
143Keratoconus (HP:0000563)1.93308923
144Increased corneal curvature (HP:0100692)1.93308923
145Medial flaring of the eyebrow (HP:0010747)1.92727057
146Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91368291
147Hypoplasia of the brainstem (HP:0002365)1.91368291
148Poor coordination (HP:0002370)1.90739960
149Anencephaly (HP:0002323)1.89077781
150Aplasia/Hypoplasia of the tongue (HP:0010295)1.88287549
151Hypsarrhythmia (HP:0002521)1.87238730
152Hypomagnesemia (HP:0002917)1.87192655
153Emotional lability (HP:0000712)1.86542035
154Protruding tongue (HP:0010808)1.85207628
155Oligomenorrhea (HP:0000876)1.84506719
156Leukodystrophy (HP:0002415)1.83839669
157Abnormality of ocular smooth pursuit (HP:0000617)1.83380427
158Hepatic necrosis (HP:0002605)1.82575328
159Polymicrogyria (HP:0002126)1.81974897
160Lipid accumulation in hepatocytes (HP:0006561)1.81919246
161Abnormal respiratory epithelium morphology (HP:0012253)1.81196836
162Abnormal respiratory motile cilium morphology (HP:0005938)1.81196836
163Decreased central vision (HP:0007663)1.77359281
164Abnormality of the metopic suture (HP:0005556)1.76745318
165Ketosis (HP:0001946)1.75248709
166Hypothermia (HP:0002045)1.74490181
167Postaxial foot polydactyly (HP:0001830)1.72700974
168Absent speech (HP:0001344)1.72218872
169Postaxial hand polydactyly (HP:0001162)1.71765275
170Aplasia/Hypoplasia of the uvula (HP:0010293)1.70616111
171Thyroid-stimulating hormone excess (HP:0002925)1.69953907
172Concave nail (HP:0001598)1.68907928
173Ketoacidosis (HP:0001993)1.68843237
174Hyperglycinemia (HP:0002154)1.68805560
175Increased hepatocellular lipid droplets (HP:0006565)1.64700435
176Dandy-Walker malformation (HP:0001305)1.64656221
177Absent rod-and cone-mediated responses on ERG (HP:0007688)1.64507779

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.65082281
2MAP4K23.85770527
3FRK3.72953192
4NTRK33.49936866
5TRIM283.28304660
6MAP3K43.17685960
7MAP3K123.13514314
8MARK13.01501868
9PNCK2.96649054
10MAP3K92.72211800
11MAP2K72.64494130
12MINK12.61628106
13EPHA42.54000215
14ZAK2.52456606
15CDK192.29496310
16CCNB12.24335743
17MAP2K42.04076195
18NTRK22.00596759
19PINK11.98763884
20PDK41.87899999
21PDK31.87899999
22GRK11.87653451
23PLK21.86249695
24TLK11.80225408
25TAOK31.67189217
26ARAF1.67130828
27DAPK21.65278721
28GRK51.63757517
29STK161.59645165
30MAPK131.55275010
31NUAK11.53435754
32BCKDK1.50517457
33INSRR1.48352075
34PAK61.35961317
35PRKCG1.33434706
36VRK21.30466707
37DAPK11.30074482
38TSSK61.26600037
39NME11.20320621
40OXSR11.18381975
41LATS21.18111602
42NTRK11.16314501
43FGFR21.12109604
44CDK51.11190211
45CAMK2A1.09043943
46CSNK1A1L1.08165284
47KSR11.07895443
48CSNK1G21.06040506
49SIK21.03326026
50SRPK11.02013556
51PHKG11.01101564
52PHKG21.01101564
53LIMK11.00330721
54NEK10.99681835
55UHMK10.97970045
56PRPF4B0.97432939
57DYRK30.97389333
58PDK20.97075472
59CDC70.96296463
60AKT30.95400280
61CDK180.94867013
62RIPK40.94354998
63PTK2B0.94113118
64KSR20.93071841
65CDK150.90881663
66PRKD30.90849043
67CDK140.90652987
68BCR0.90433029
69CSNK1G30.88366656
70TESK10.87960741
71STK380.86403068
72MAPK150.86353159
73CAMKK20.84355291
74VRK10.83662692
75PLK40.82633358
76SGK2230.81162129
77SGK4940.81162129
78CAMKK10.81075658
79ERBB30.80863053
80LMTK20.79399803
81CDK11A0.78644743
82DAPK30.78228623
83PLK10.77146813
84PRKCI0.76961954
85ADRBK10.76929400
86RPS6KA50.73163549
87EPHB20.71992662
88CAMK2B0.71903722
89MAP2K60.71866330
90BRSK20.71380735
91STK390.70515322
92MYLK0.69185682
93CAMK2G0.68809812
94GRK70.68525986
95WNK40.68262822
96ACVR1B0.65922396
97MUSK0.64911223
98DYRK1A0.62891829
99FLT30.62749761
100BRAF0.62542339
101TNK20.61149388
102PRKCE0.60814795
103TNIK0.59559305
104SIK30.59355679
105CHEK20.58912984
106TYRO30.55074696
107NEK20.54932037
108RPS6KA40.53367584
109WNK10.52259131
110CAMK10.51875632
111DYRK1B0.50910626
112CSNK1A10.50838212
113PLK30.50297852
114IRAK20.50198313
115PRKACA0.50150707
116DYRK20.50137849
117STK110.49506860
118EIF2AK30.49429550
119ATR0.49239396
120BUB10.48974113
121BRSK10.48719249
122BMPR1B0.48711083
123PRKCZ0.48620078
124TXK0.47435335
125MKNK20.47323407
126EPHA30.46331637
127TIE10.46077060
128SCYL20.45790940
129SGK10.45336728
130ICK0.45309232
131PIK3CA0.45148289
132MAPKAPK50.43498904
133PRKAA10.43369328
134ERBB40.42832272
135ALK0.42800073
136PAK30.42207255
137ROCK20.41831151
138FES0.41747522
139SGK20.41697219
140RPS6KA30.41051160
141PDK10.40502952
142ADRBK20.40441797
143MAP2K20.40294926
144PRKCB0.39753141
145CSNK1D0.39495121
146BMPR20.39018315
147CAMK2D0.38137286
148WNK30.38111239
149CAMK1G0.38009349
150CSNK1G10.37885510
151CHUK0.37680795
152CSNK1E0.32538063

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.48321232
2Nicotine addiction_Homo sapiens_hsa050333.81442916
3Collecting duct acid secretion_Homo sapiens_hsa049663.35307544
4Oxidative phosphorylation_Homo sapiens_hsa001903.25384125
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.92287788
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.80595243
7Parkinsons disease_Homo sapiens_hsa050122.75312085
8Protein export_Homo sapiens_hsa030602.48434866
9GABAergic synapse_Homo sapiens_hsa047272.45929142
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45163408
11Fanconi anemia pathway_Homo sapiens_hsa034602.27630167
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.22482605
13Amphetamine addiction_Homo sapiens_hsa050312.21738410
14Circadian entrainment_Homo sapiens_hsa047132.20106323
15Olfactory transduction_Homo sapiens_hsa047402.18772367
16Morphine addiction_Homo sapiens_hsa050322.18538917
17Alzheimers disease_Homo sapiens_hsa050102.12764563
18Dopaminergic synapse_Homo sapiens_hsa047282.12311655
19RNA polymerase_Homo sapiens_hsa030202.09362431
20Vibrio cholerae infection_Homo sapiens_hsa051102.07626018
21Homologous recombination_Homo sapiens_hsa034402.06454175
22Long-term potentiation_Homo sapiens_hsa047202.06297294
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.94410137
24Cardiac muscle contraction_Homo sapiens_hsa042601.93831277
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92305057
26Basal transcription factors_Homo sapiens_hsa030221.91978726
27Glutamatergic synapse_Homo sapiens_hsa047241.90459240
28Huntingtons disease_Homo sapiens_hsa050161.82029367
29Taste transduction_Homo sapiens_hsa047421.76675969
30Serotonergic synapse_Homo sapiens_hsa047261.71692281
31Cholinergic synapse_Homo sapiens_hsa047251.71267920
32Cocaine addiction_Homo sapiens_hsa050301.69822664
33Insulin secretion_Homo sapiens_hsa049111.66215766
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66133506
35Salivary secretion_Homo sapiens_hsa049701.59645770
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58853651
37Nitrogen metabolism_Homo sapiens_hsa009101.56256759
38Steroid biosynthesis_Homo sapiens_hsa001001.52188645
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52041439
40RNA degradation_Homo sapiens_hsa030181.51767561
41Selenocompound metabolism_Homo sapiens_hsa004501.50004516
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.45074662
43Long-term depression_Homo sapiens_hsa047301.42617515
44Renin secretion_Homo sapiens_hsa049241.39327112
45Regulation of autophagy_Homo sapiens_hsa041401.38453799
46Calcium signaling pathway_Homo sapiens_hsa040201.33915700
47Gastric acid secretion_Homo sapiens_hsa049711.33685878
48Linoleic acid metabolism_Homo sapiens_hsa005911.33667489
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29521802
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29346453
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28955674
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28697937
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27475785
54Pyruvate metabolism_Homo sapiens_hsa006201.27431267
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24986913
56Peroxisome_Homo sapiens_hsa041461.24117380
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22756809
58Gap junction_Homo sapiens_hsa045401.22205883
59Oxytocin signaling pathway_Homo sapiens_hsa049211.20318400
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20194577
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17133862
62Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15943283
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13390701
64Propanoate metabolism_Homo sapiens_hsa006401.13109909
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00263213
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99959621
67Sulfur relay system_Homo sapiens_hsa041220.99930288
68Oocyte meiosis_Homo sapiens_hsa041140.99612112
69Axon guidance_Homo sapiens_hsa043600.98144354
70Nucleotide excision repair_Homo sapiens_hsa034200.97656472
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.95929083
72GnRH signaling pathway_Homo sapiens_hsa049120.95130423
73Pyrimidine metabolism_Homo sapiens_hsa002400.94737726
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93127617
75Tryptophan metabolism_Homo sapiens_hsa003800.91392692
76Fatty acid elongation_Homo sapiens_hsa000620.90245622
77Base excision repair_Homo sapiens_hsa034100.86080712
78Phototransduction_Homo sapiens_hsa047440.85689992
79Rheumatoid arthritis_Homo sapiens_hsa053230.84695458
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84177626
81Mismatch repair_Homo sapiens_hsa034300.83489112
82* Metabolic pathways_Homo sapiens_hsa011000.81266888
83One carbon pool by folate_Homo sapiens_hsa006700.81090823
84Purine metabolism_Homo sapiens_hsa002300.80383447
85RNA transport_Homo sapiens_hsa030130.80351275
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80197043
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78996889
88Estrogen signaling pathway_Homo sapiens_hsa049150.78297104
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76294187
90Vitamin B6 metabolism_Homo sapiens_hsa007500.72887645
91Alcoholism_Homo sapiens_hsa050340.71870016
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71743481
93cAMP signaling pathway_Homo sapiens_hsa040240.71264716
94Phagosome_Homo sapiens_hsa041450.71220532
95Melanogenesis_Homo sapiens_hsa049160.71051267
96Ribosome_Homo sapiens_hsa030100.67478498
97ErbB signaling pathway_Homo sapiens_hsa040120.66409871
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66037712
99Caffeine metabolism_Homo sapiens_hsa002320.65999857
100Glucagon signaling pathway_Homo sapiens_hsa049220.64998423
101Chemical carcinogenesis_Homo sapiens_hsa052040.64877043
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64729851
103Non-homologous end-joining_Homo sapiens_hsa034500.63583356
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61740039
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.61052165
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60954893
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59921609
108Proteasome_Homo sapiens_hsa030500.59689459
109Basal cell carcinoma_Homo sapiens_hsa052170.58053901
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57452289
111Type II diabetes mellitus_Homo sapiens_hsa049300.55677947
112Sulfur metabolism_Homo sapiens_hsa009200.54606109
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53987405
114Type I diabetes mellitus_Homo sapiens_hsa049400.53488565
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.53454424
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53060005
117ABC transporters_Homo sapiens_hsa020100.52232208
118beta-Alanine metabolism_Homo sapiens_hsa004100.50030762
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50022585
120Arachidonic acid metabolism_Homo sapiens_hsa005900.48960046
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48493113
122MAPK signaling pathway_Homo sapiens_hsa040100.48178299
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47849804
124Glioma_Homo sapiens_hsa052140.47210975
125Ovarian steroidogenesis_Homo sapiens_hsa049130.46588634
126Retinol metabolism_Homo sapiens_hsa008300.45237558
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44704791
128Dilated cardiomyopathy_Homo sapiens_hsa054140.44673849
129Spliceosome_Homo sapiens_hsa030400.44352889
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42993035
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41763663
132DNA replication_Homo sapiens_hsa030300.40892181
133Glutathione metabolism_Homo sapiens_hsa004800.40074304
134Butanoate metabolism_Homo sapiens_hsa006500.39360901
135Thyroid hormone synthesis_Homo sapiens_hsa049180.39230475
136Fatty acid metabolism_Homo sapiens_hsa012120.39223827
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39030071
138Dorso-ventral axis formation_Homo sapiens_hsa043200.37304514
139Ras signaling pathway_Homo sapiens_hsa040140.36789601
140Circadian rhythm_Homo sapiens_hsa047100.35327589
141Folate biosynthesis_Homo sapiens_hsa007900.35053597
142Carbon metabolism_Homo sapiens_hsa012000.32404929
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.31408479
144Rap1 signaling pathway_Homo sapiens_hsa040150.31313620
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27636330
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.27096335
147Wnt signaling pathway_Homo sapiens_hsa043100.26772336
148Phospholipase D signaling pathway_Homo sapiens_hsa040720.26717484
149Hedgehog signaling pathway_Homo sapiens_hsa043400.26025132
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25965782
151Pancreatic secretion_Homo sapiens_hsa049720.25886800
152Biosynthesis of amino acids_Homo sapiens_hsa012300.25679822
153Melanoma_Homo sapiens_hsa052180.24373579
154Cyanoamino acid metabolism_Homo sapiens_hsa004600.23943447
155* Endocytosis_Homo sapiens_hsa041440.21040773
156Fructose and mannose metabolism_Homo sapiens_hsa000510.20873464
157Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20842431
158Ether lipid metabolism_Homo sapiens_hsa005650.18203506
159Neurotrophin signaling pathway_Homo sapiens_hsa047220.17581644
160Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17231952
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.16669830
162Insulin signaling pathway_Homo sapiens_hsa049100.16586068

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