PIP5K1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.62974787
2locomotory exploration behavior (GO:0035641)6.32943670
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.04578596
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.51961023
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.46427209
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.39843460
7glutamate secretion (GO:0014047)5.24235920
8vocalization behavior (GO:0071625)5.16423814
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.10109489
10regulation of synaptic vesicle exocytosis (GO:2000300)5.03915504
11* synaptic vesicle exocytosis (GO:0016079)4.77008788
12regulation of glutamate receptor signaling pathway (GO:1900449)4.76262438
13layer formation in cerebral cortex (GO:0021819)4.69775763
14exploration behavior (GO:0035640)4.48745885
15regulation of synapse structural plasticity (GO:0051823)4.47438995
16regulation of synaptic vesicle transport (GO:1902803)4.43264011
17sodium ion export (GO:0071436)4.30700496
18neurotransmitter secretion (GO:0007269)4.29242368
19regulation of neuronal synaptic plasticity (GO:0048168)4.19421293
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.13838090
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.13335913
22protein localization to synapse (GO:0035418)4.13103080
23proline transport (GO:0015824)4.12256333
24dendritic spine morphogenesis (GO:0060997)4.03531414
25cellular potassium ion homeostasis (GO:0030007)4.00763358
26regulation of ARF protein signal transduction (GO:0032012)3.95970946
27positive regulation of synapse maturation (GO:0090129)3.86479476
28neuronal action potential propagation (GO:0019227)3.83973809
29activation of protein kinase A activity (GO:0034199)3.82338451
30G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.70693252
31neuromuscular process controlling balance (GO:0050885)3.69062955
32synaptic transmission, glutamatergic (GO:0035249)3.68674016
33long-term memory (GO:0007616)3.67803166
34neurotransmitter-gated ion channel clustering (GO:0072578)3.66667810
35positive regulation of membrane potential (GO:0045838)3.62534782
36gamma-aminobutyric acid transport (GO:0015812)3.60913793
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.54190647
38glutamate receptor signaling pathway (GO:0007215)3.53307537
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.50281413
40cerebellar Purkinje cell differentiation (GO:0021702)3.43904180
41amino acid import (GO:0043090)3.42796652
42protein localization to endosome (GO:0036010)3.40976245
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37631207
44regulation of dendritic spine morphogenesis (GO:0061001)3.37213085
45regulation of synaptic plasticity (GO:0048167)3.35157511
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34229358
47dendrite morphogenesis (GO:0048813)3.33833500
48regulation of postsynaptic membrane potential (GO:0060078)3.25662872
49* cytoskeletal anchoring at plasma membrane (GO:0007016)3.25153001
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.24840766
51cell communication by electrical coupling (GO:0010644)3.24500644
52neuron cell-cell adhesion (GO:0007158)3.24360274
53neuron-neuron synaptic transmission (GO:0007270)3.23326131
54regulation of neurotransmitter secretion (GO:0046928)3.22729815
55neurotransmitter transport (GO:0006836)3.20362284
56regulation of early endosome to late endosome transport (GO:2000641)3.14085490
57regulation of ARF GTPase activity (GO:0032312)3.08538555
58glycine transport (GO:0015816)3.05572795
59auditory behavior (GO:0031223)3.05434685
60negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.03352322
61clathrin coat assembly (GO:0048268)3.02910912
62neuronal ion channel clustering (GO:0045161)3.02348253
63positive regulation of neurotransmitter secretion (GO:0001956)3.01571188
64potassium ion import (GO:0010107)3.00603308
65regulation of neurotransmitter levels (GO:0001505)2.99606149
66positive regulation of fibroblast migration (GO:0010763)2.98566559
67response to auditory stimulus (GO:0010996)2.95341348
68regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94400376
69long-term synaptic potentiation (GO:0060291)2.93428156
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93166719
71dendritic spine organization (GO:0097061)2.92431908
72vesicle transport along microtubule (GO:0047496)2.92142567
73regulation of clathrin-mediated endocytosis (GO:2000369)2.91420704
74cerebellar granule cell differentiation (GO:0021707)2.89364597
75cerebellar Purkinje cell layer development (GO:0021680)2.88175475
76regulation of neurotransmitter transport (GO:0051588)2.86527125
77regulation of vesicle fusion (GO:0031338)2.85780670
78prepulse inhibition (GO:0060134)2.85506999
79establishment of nucleus localization (GO:0040023)2.84821379
80L-amino acid import (GO:0043092)2.84656074
81regulation of dendritic spine development (GO:0060998)2.83936429
82stress fiber assembly (GO:0043149)2.83583966
83negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.83261506
84negative regulation of cell killing (GO:0031342)2.83261506
85membrane depolarization during action potential (GO:0086010)2.83076091
86alanine transport (GO:0032328)2.82112028
87membrane depolarization (GO:0051899)2.81716133
88positive regulation of neurotransmitter transport (GO:0051590)2.80792985
89response to pheromone (GO:0019236)2.80286961
90regulation of synapse maturation (GO:0090128)2.78742651
91positive regulation of protein dephosphorylation (GO:0035307)2.78316105
92neuromuscular process controlling posture (GO:0050884)2.78272957
93barbed-end actin filament capping (GO:0051016)2.78166383
94positive regulation of dendritic spine development (GO:0060999)2.78118235
95regulation of synaptic transmission, glutamatergic (GO:0051966)2.77323312
96cell migration in hindbrain (GO:0021535)2.77197479
97* synaptic vesicle endocytosis (GO:0048488)2.76150185
98neuron recognition (GO:0008038)2.74896577
99neuromuscular process (GO:0050905)2.74529916
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.73130185
101gamma-aminobutyric acid signaling pathway (GO:0007214)2.72328333
102protein targeting to plasma membrane (GO:0072661)2.71970368
103semaphorin-plexin signaling pathway (GO:0071526)2.70497682
104positive regulation of dendritic spine morphogenesis (GO:0061003)2.70120357
105cellular sodium ion homeostasis (GO:0006883)2.69752168
106long term synaptic depression (GO:0060292)2.66828041
107regulation of synaptic transmission (GO:0050804)2.66405729
108signal complex assembly (GO:0007172)2.66145456
109negative regulation of erythrocyte differentiation (GO:0045647)2.65561907
110nerve growth factor signaling pathway (GO:0038180)2.65290289
111positive regulation of synaptic transmission (GO:0050806)2.64922421
112cell-cell junction maintenance (GO:0045217)2.54503018
113cortical actin cytoskeleton organization (GO:0030866)2.51771528
114potassium ion homeostasis (GO:0055075)2.49668521
115cell-substrate adherens junction assembly (GO:0007045)2.49534091
116focal adhesion assembly (GO:0048041)2.49534091
117protein retention in ER lumen (GO:0006621)2.48692291
118mannose metabolic process (GO:0006013)2.43009077
119positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.41476982
120positive regulation of receptor recycling (GO:0001921)2.40019324
121mating behavior (GO:0007617)2.39537997
122* adherens junction assembly (GO:0034333)2.37839704
123dopamine receptor signaling pathway (GO:0007212)2.37771671
124positive regulation of axon extension (GO:0045773)2.33061953
125vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.31057246
126negative regulation of dendrite morphogenesis (GO:0050774)2.30420530
127positive regulation of Rap GTPase activity (GO:0032854)2.30375059
128peptidyl-tyrosine autophosphorylation (GO:0038083)2.28142644
129negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.27801936
130activation of MAPKKK activity (GO:0000185)2.27279918
131regulation of voltage-gated calcium channel activity (GO:1901385)2.26389923
132cellular response to catecholamine stimulus (GO:0071870)2.25898755
133cellular response to monoamine stimulus (GO:0071868)2.25898755
134positive regulation of dendrite development (GO:1900006)2.25300417
135endocytic recycling (GO:0032456)2.25244779
136cortical cytoskeleton organization (GO:0030865)2.25116600
137protein heterotrimerization (GO:0070208)2.24359262
138adenosine receptor signaling pathway (GO:0001973)2.23458033
139cell-substrate junction assembly (GO:0007044)2.21934570
140maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.21728182
141negative regulation of synaptic transmission, GABAergic (GO:0032229)2.19122946
142response to acidic pH (GO:0010447)2.18581639
143actin filament capping (GO:0051693)2.12425216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.84753752
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.95337455
3RARB_27405468_Chip-Seq_BRAIN_Mouse2.93927890
4DROSHA_22980978_ChIP-Seq_HELA_Human2.93739326
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.79317900
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60874004
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.60150524
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56876168
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56457030
10REST_21632747_ChIP-Seq_MESCs_Mouse2.53093618
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51390184
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45374587
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45374587
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34686993
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31430161
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27745778
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.17639997
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17037073
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07552967
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.07188984
21* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06481719
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05891018
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02901612
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.01604049
25* KDM2B_26808549_Chip-Seq_K562_Human2.01390542
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.00726761
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88621158
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88223468
29DNAJC2_21179169_ChIP-ChIP_NT2_Human1.83175185
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80153805
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.79219635
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.78718159
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.74561096
34* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.74335345
35GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.74302851
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72781575
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70956565
38KDM2B_26808549_Chip-Seq_DND41_Human1.70676077
39* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68627560
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68310690
41GBX2_23144817_ChIP-Seq_PC3_Human1.67225341
42RACK7_27058665_Chip-Seq_MCF-7_Human1.65839677
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65648841
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.63253387
45VDR_21846776_ChIP-Seq_THP-1_Human1.57510558
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56415939
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.56194806
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.54918623
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54856897
50* LXR_22292898_ChIP-Seq_THP-1_Human1.54097894
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.52857180
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.52268251
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47002028
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44404811
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.41949785
56* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41085601
57AR_21572438_ChIP-Seq_LNCaP_Human1.39623164
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38706548
59* KDM2B_26808549_Chip-Seq_JURKAT_Human1.38504684
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38348668
61RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36529619
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35458892
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33432296
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32712198
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30219639
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.29965943
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29080828
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28251671
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.28078005
70P68_20966046_ChIP-Seq_HELA_Human1.25844986
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24684801
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24030379
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22928852
74* RING1B_27294783_Chip-Seq_ESCs_Mouse1.22602307
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.20055912
76* TCF7_22412390_ChIP-Seq_EML_Mouse1.19669818
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19316547
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18688024
79SPI1_23127762_ChIP-Seq_K562_Human1.15010060
80CLOCK_20551151_ChIP-Seq_293T_Human1.14400456
81* AR_19668381_ChIP-Seq_PC3_Human1.14315396
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11763337
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11354688
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10386982
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09900384
86* TP53_23651856_ChIP-Seq_MEFs_Mouse1.09483348
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09438129
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08151302
89TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.07632311
90* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07376446
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.07164158
92SMC4_20622854_ChIP-Seq_HELA_Human1.07116686
93TET1_21490601_ChIP-Seq_MESCs_Mouse1.06451334
94* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04710211
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03837790
96MYC_22102868_ChIP-Seq_BL_Human1.02655221
97VDR_24763502_ChIP-Seq_THP-1_Human1.01692141
98TP53_22127205_ChIP-Seq_IMR90_Human1.01174919
99TP53_20018659_ChIP-ChIP_R1E_Mouse1.01009055
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96196850
101ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94764249
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94508425
103TBX20_22080862_ChIP-Seq_HEART_Mouse0.94357623
104TBX20_22328084_ChIP-Seq_HEART_Mouse0.94357623
105* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93377516
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92936042
107MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92882827
108SMAD4_21799915_ChIP-Seq_A2780_Human0.92115268
109* CTCF_27219007_Chip-Seq_Bcells_Human0.91277070
110RXR_22108803_ChIP-Seq_LS180_Human0.90702342
111E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90644386
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90324482
113P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89588916
114CREB1_26743006_Chip-Seq_LNCaP_Human0.88953575
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.88738718
116AHR_22903824_ChIP-Seq_MCF-7_Human0.87866910
117KLF4_19829295_ChIP-Seq_ESCs_Human0.87794124
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84820151
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84335751
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.84239066
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.84041804
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83481726
123NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82601347
124* OCT4_19829295_ChIP-Seq_ESCs_Human0.82277454
125ZNF274_21170338_ChIP-Seq_K562_Hela0.82059037
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.81731136
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81260594
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.80678017
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80377484
130OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80118127
131GATA1_19941826_ChIP-Seq_K562_Human0.79610634
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.77767341
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.77701720
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.76484825

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004859_abnormal_synaptic_plasticity7.47989704
2* MP0003635_abnormal_synaptic_transmissio4.31153809
3MP0004270_analgesia3.59130070
4MP0003880_abnormal_central_pattern3.56946372
5MP0008438_abnormal_cutaneous_collagen3.45342013
6MP0002063_abnormal_learning/memory/cond3.36161908
7MP0009745_abnormal_behavioral_response3.17387469
8MP0002064_seizures3.09208773
9MP0009046_muscle_twitch3.07810665
10MP0001968_abnormal_touch/_nociception2.82611719
11MP0003279_aneurysm2.81923049
12MP0004858_abnormal_nervous_system2.67220288
13MP0000569_abnormal_digit_pigmentation2.59953763
14MP0002572_abnormal_emotion/affect_behav2.58285782
15MP0005423_abnormal_somatic_nervous2.55550839
16MP0001958_emphysema2.43805237
17MP0002734_abnormal_mechanical_nocicepti2.39185226
18MP0008569_lethality_at_weaning2.39164470
19MP0002822_catalepsy2.29964324
20MP0005409_darkened_coat_color2.22164610
21MP0009780_abnormal_chondrocyte_physiolo2.17285961
22MP0002736_abnormal_nociception_after2.15061731
23MP0002272_abnormal_nervous_system2.14579666
24MP0001486_abnormal_startle_reflex2.12910950
25MP0004510_myositis2.09291008
26MP0003329_amyloid_beta_deposits2.06622736
27* MP0004811_abnormal_neuron_physiology2.03289995
28MP0002735_abnormal_chemical_nociception2.02763586
29MP0002909_abnormal_adrenal_gland2.02013615
30MP0001501_abnormal_sleep_pattern1.99292255
31MP0003303_peritoneal_inflammation1.99109393
32MP0002733_abnormal_thermal_nociception1.97401053
33MP0008961_abnormal_basal_metabolism1.89207789
34MP0001970_abnormal_pain_threshold1.84466249
35MP0003172_abnormal_lysosome_physiology1.84224109
36MP0003566_abnormal_cell_adhesion1.83731290
37MP0001440_abnormal_grooming_behavior1.83383508
38MP0003091_abnormal_cell_migration1.76555379
39MP0003879_abnormal_hair_cell1.76162979
40MP0002067_abnormal_sensory_capabilities1.71143760
41MP0005257_abnormal_intraocular_pressure1.68390563
42MP0003075_altered_response_to1.68165616
43MP0002184_abnormal_innervation1.64230020
44MP0001849_ear_inflammation1.59843861
45MP0005503_abnormal_tendon_morphology1.59799140
46MP0003633_abnormal_nervous_system1.58484338
47MP0002557_abnormal_social/conspecific_i1.56060051
48MP0000778_abnormal_nervous_system1.50410584
49MP0009840_abnormal_foam_cell1.49287085
50* MP0000955_abnormal_spinal_cord1.46391837
51MP0004272_abnormal_basement_membrane1.45905583
52MP0005386_behavior/neurological_phenoty1.41720001
53MP0004924_abnormal_behavior1.41720001
54MP0010368_abnormal_lymphatic_system1.40194953
55MP0000604_amyloidosis1.35716184
56* MP0002066_abnormal_motor_capabilities/c1.30694020
57MP0004885_abnormal_endolymph1.28630670
58MP0000767_abnormal_smooth_muscle1.27004550
59MP0005167_abnormal_blood-brain_barrier1.26857729
60MP0002882_abnormal_neuron_morphology1.25525706
61MP0008260_abnormal_autophagy1.25081041
62MP0003631_nervous_system_phenotype1.23154171
63MP0005275_abnormal_skin_tensile1.22325810
64MP0003690_abnormal_glial_cell1.13571751
65MP0002249_abnormal_larynx_morphology1.12461489
66MP0003787_abnormal_imprinting1.12455251
67MP0002295_abnormal_pulmonary_circulatio1.09531515
68MP0008874_decreased_physiological_sensi1.08148806
69MP0003283_abnormal_digestive_organ1.07461583
70MP0002998_abnormal_bone_remodeling1.04977419
71* MP0002152_abnormal_brain_morphology1.03898417
72MP0005595_abnormal_vascular_smooth1.02729375
73MP0001502_abnormal_circadian_rhythm1.01816167
74MP0000751_myopathy0.99893335
75MP0002877_abnormal_melanocyte_morpholog0.98234489
76MP0005508_abnormal_skeleton_morphology0.95827784
77MP0010234_abnormal_vibrissa_follicle0.93685758
78MP0002896_abnormal_bone_mineralization0.92117720
79MP0005166_decreased_susceptibility_to0.91195842
80MP0005023_abnormal_wound_healing0.89755749
81MP0003123_paternal_imprinting0.89158592
82MP0004130_abnormal_muscle_cell0.88724914
83MP0003634_abnormal_glial_cell0.86608094
84MP0002089_abnormal_postnatal_growth/wei0.86524576
85* MP0002069_abnormal_eating/drinking_beha0.84943637
86MP0000013_abnormal_adipose_tissue0.83966655
87MP0003632_abnormal_nervous_system0.83681304
88MP0003436_decreased_susceptibility_to0.82346648
89MP0000747_muscle_weakness0.81931351
90MP0002133_abnormal_respiratory_system0.81493913
91MP0005388_respiratory_system_phenotype0.81493913
92MP0001542_abnormal_bone_strength0.81196020
93MP0003300_gastrointestinal_ulcer0.80208117
94MP0008872_abnormal_physiological_respon0.80124870
95MP0005623_abnormal_meninges_morphology0.79802266
96MP0005535_abnormal_body_temperature0.78607061
97MP0001984_abnormal_olfaction0.78303719
98MP0005645_abnormal_hypothalamus_physiol0.78027740
99MP0003191_abnormal_cellular_cholesterol0.77740844
100MP0005646_abnormal_pituitary_gland0.77633716
101MP0002090_abnormal_vision0.77614425
102MP0003183_abnormal_peptide_metabolism0.77264605
103MP0004233_abnormal_muscle_weight0.76833133
104MP0009384_cardiac_valve_regurgitation0.76813348
105MP0000759_abnormal_skeletal_muscle0.75565774
106MP0001299_abnormal_eye_distance/0.74140113
107MP0003045_fibrosis0.74111851
108MP0000920_abnormal_myelination0.73758462
109MP0005390_skeleton_phenotype0.72199001
110MP0000733_abnormal_muscle_development0.71926671
111MP0002229_neurodegeneration0.71186916
112MP0000003_abnormal_adipose_tissue0.70995076
113MP0005058_abnormal_lysosome_morphology0.68723440
114MP0001177_atelectasis0.67796539
115MP0000681_abnormal_thyroid_gland0.67395515
116MP0003453_abnormal_keratinocyte_physiol0.66830004
117MP0004145_abnormal_muscle_electrophysio0.66565233
118MP0000534_abnormal_ureter_morphology0.66437500
119MP0001533_abnormal_skeleton_physiology0.66009776
120MP0005076_abnormal_cell_differentiation0.64955129
121MP0006138_congestive_heart_failure0.64653196
122MP0004085_abnormal_heartbeat0.64262325
123MP0004142_abnormal_muscle_tone0.62185988
124MP0003705_abnormal_hypodermis_morpholog0.62003245
125MP0001348_abnormal_lacrimal_gland0.58899801
126MP0004484_altered_response_of0.57062969
127MP0010769_abnormal_survival0.56320462
128MP0010386_abnormal_urinary_bladder0.55703013
129MP0005499_abnormal_olfactory_system0.51875810
130MP0005394_taste/olfaction_phenotype0.51875810
131MP0010768_mortality/aging0.51419166
132MP0006276_abnormal_autonomic_nervous0.49618225
133MP0002082_postnatal_lethality0.49145973
134MP0010770_preweaning_lethality0.49145973
135MP0008770_decreased_survivor_rate0.49007268
136MP0003122_maternal_imprinting0.48816714
137MP0005310_abnormal_salivary_gland0.47956741
138MP0003956_abnormal_body_size0.47221556
139MP0004742_abnormal_vestibular_system0.46524851
140MP0001943_abnormal_respiration0.44883523
141MP0009278_abnormal_bone_marrow0.44360091

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.91955067
2Focal motor seizures (HP:0011153)5.22806696
3Visual hallucinations (HP:0002367)5.19289208
4Focal seizures (HP:0007359)4.80589870
5Protrusio acetabuli (HP:0003179)4.00865247
6Supranuclear gaze palsy (HP:0000605)3.91633413
7Action tremor (HP:0002345)3.91378704
8Premature rupture of membranes (HP:0001788)3.78595501
9Epileptic encephalopathy (HP:0200134)3.61370957
10Progressive cerebellar ataxia (HP:0002073)3.57016465
11Papilledema (HP:0001085)3.53901925
12Abnormality of the lower motor neuron (HP:0002366)3.53353635
13Atonic seizures (HP:0010819)3.49429603
14Mutism (HP:0002300)3.44717175
15Febrile seizures (HP:0002373)3.33321303
16Poor eye contact (HP:0000817)3.28567833
17Absence seizures (HP:0002121)3.19222741
18Ankle clonus (HP:0011448)3.13435453
19Shallow orbits (HP:0000586)3.09713196
20Depression (HP:0000716)3.07340993
21Impaired social interactions (HP:0000735)3.05944391
22Abnormal social behavior (HP:0012433)3.05944391
23Hemiplegia (HP:0002301)3.01558146
24Impaired smooth pursuit (HP:0007772)3.01538588
25Generalized tonic-clonic seizures (HP:0002069)2.96516388
26Urinary bladder sphincter dysfunction (HP:0002839)2.88187457
27Postural instability (HP:0002172)2.87533597
28Abnormality of binocular vision (HP:0011514)2.87478506
29Diplopia (HP:0000651)2.87478506
30Dialeptic seizures (HP:0011146)2.84917977
31Impaired vibration sensation in the lower limbs (HP:0002166)2.79156647
32Pointed chin (HP:0000307)2.77071988
33Dysmetric saccades (HP:0000641)2.76625833
34Dysdiadochokinesis (HP:0002075)2.75638518
35Annular pancreas (HP:0001734)2.75528837
36Gaze-evoked nystagmus (HP:0000640)2.75135667
37Genetic anticipation (HP:0003743)2.71965246
38Insomnia (HP:0100785)2.69062257
39Apathy (HP:0000741)2.67358763
40Broad-based gait (HP:0002136)2.67069107
41Abnormality of ocular smooth pursuit (HP:0000617)2.66509661
42Stereotypic behavior (HP:0000733)2.64203053
43Truncal ataxia (HP:0002078)2.59289029
44Abnormal eating behavior (HP:0100738)2.59079553
45Broad metatarsal (HP:0001783)2.58283978
46Hyperacusis (HP:0010780)2.55009055
47Dysmetria (HP:0001310)2.53511274
48Urinary urgency (HP:0000012)2.53132705
49Bladder diverticulum (HP:0000015)2.52821882
50Aortic aneurysm (HP:0004942)2.49297237
51Vascular tortuosity (HP:0004948)2.47006538
52Increased variability in muscle fiber diameter (HP:0003557)2.45662308
53Amyotrophic lateral sclerosis (HP:0007354)2.44004205
54Diminished motivation (HP:0000745)2.42223084
55Neuronal loss in central nervous system (HP:0002529)2.36083209
56Intention tremor (HP:0002080)2.36080223
57Torticollis (HP:0000473)2.36046006
58Spinal rigidity (HP:0003306)2.34069680
59Inappropriate behavior (HP:0000719)2.33706473
60Turricephaly (HP:0000262)2.32783163
61Ventricular fibrillation (HP:0001663)2.31211847
62Amblyopia (HP:0000646)2.30993581
63Increased cerebral lipofuscin (HP:0011813)2.30934926
64Genu recurvatum (HP:0002816)2.30873071
65Hemiparesis (HP:0001269)2.30566503
66Obstructive sleep apnea (HP:0002870)2.30245346
67Cerebral inclusion bodies (HP:0100314)2.30136765
68Anxiety (HP:0000739)2.27590040
69Arterial tortuosity (HP:0005116)2.27490420
70Bundle branch block (HP:0011710)2.25717904
71Mitral regurgitation (HP:0001653)2.23093638
72Distal lower limb amyotrophy (HP:0008944)2.22777168
73Broad face (HP:0000283)2.22135051
74Aortic dissection (HP:0002647)2.19851677
75Wormian bones (HP:0002645)2.18181859
76Nuclear cataract (HP:0100018)2.16118178
77Vertebral compression fractures (HP:0002953)2.16031549
78Ankle contracture (HP:0006466)2.15386013
79Focal dystonia (HP:0004373)2.15092492
80Atrophic scars (HP:0001075)2.14711209
81Bradykinesia (HP:0002067)2.14555829
82Dysostosis multiplex (HP:0000943)2.14473013
83Fragile skin (HP:0001030)2.14276497
84Hypoventilation (HP:0002791)2.13909679
85Spastic gait (HP:0002064)2.13273692
86Lower limb asymmetry (HP:0100559)2.10398063
87Status epilepticus (HP:0002133)2.09944359
88Increased connective tissue (HP:0009025)2.09151730
89Bowel diverticulosis (HP:0005222)2.09106477
90Neurofibrillary tangles (HP:0002185)2.08346406
91Abnormality of the periventricular white matter (HP:0002518)2.07814640
92Macroorchidism (HP:0000053)2.07295774
93Dilatation of the ascending aorta (HP:0005111)2.06980222
94Rapidly progressive (HP:0003678)2.06651416
95Elfin facies (HP:0004428)2.06063426
96Upper limb amyotrophy (HP:0009129)2.05909040
97Distal upper limb amyotrophy (HP:0007149)2.05909040
98Lower limb amyotrophy (HP:0007210)2.05716316
99Abnormality of skeletal muscle fiber size (HP:0012084)2.05601783
100Neonatal short-limb short stature (HP:0008921)2.04440219
101Type 1 muscle fiber predominance (HP:0003803)2.01923125
102Aneurysm (HP:0002617)2.01304138
103Disproportionate tall stature (HP:0001519)1.99661553
104Drooling (HP:0002307)1.99218005
105Excessive salivation (HP:0003781)1.99218005
106Spinal canal stenosis (HP:0003416)1.98054433
107Cervical subluxation (HP:0003308)1.97778643
108Mildly elevated creatine phosphokinase (HP:0008180)1.95336905
109Ulnar bowing (HP:0003031)1.94956615
110Hand muscle atrophy (HP:0009130)1.94141896
111Agitation (HP:0000713)1.92923653
112Megalencephaly (HP:0001355)1.92328623
113Distal lower limb muscle weakness (HP:0009053)1.89461507
114Resting tremor (HP:0002322)1.89239699
115Scanning speech (HP:0002168)1.88813004
116Blue sclerae (HP:0000592)1.88552816
117Mitral valve prolapse (HP:0001634)1.88401190
118Abnormality of saccadic eye movements (HP:0000570)1.88161551
119Bronchomalacia (HP:0002780)1.88105101
120Axonal loss (HP:0003447)1.88030287
121Craniofacial dystonia (HP:0012179)1.86489686
122Progressive inability to walk (HP:0002505)1.85161052
123Impaired vibratory sensation (HP:0002495)1.84647551
124Slender build (HP:0001533)1.83582447
125Ankyloglossia (HP:0010296)1.83161817
126Hyperextensible skin (HP:0000974)1.82745145
127Mild short stature (HP:0003502)1.82029778
128Peripheral hypomyelination (HP:0007182)1.81874858
129Termporal pattern (HP:0011008)1.80033482
130Insidious onset (HP:0003587)1.80033482
131Lower limb muscle weakness (HP:0007340)1.79888604
132Tetraplegia (HP:0002445)1.79075441
133Abnormality of glycosphingolipid metabolism (HP:0004343)1.78601335
134Abnormality of glycolipid metabolism (HP:0010969)1.78601335
135Abnormality of liposaccharide metabolism (HP:0010968)1.78601335
136Hypercortisolism (HP:0001578)1.76848791
137Abnormality of polysaccharide metabolism (HP:0011012)1.76317427
138Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76317427
139Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76317427
140Stridor (HP:0010307)1.76184806
141Difficulty climbing stairs (HP:0003551)1.75339385
142Intellectual disability, profound (HP:0002187)1.75174834
143Urinary glycosaminoglycan excretion (HP:0003541)1.75125795
144Mucopolysacchariduria (HP:0008155)1.75125795
145Sleep apnea (HP:0010535)1.74498474
146Achilles tendon contracture (HP:0001771)1.74290113
147Epileptiform EEG discharges (HP:0011182)1.73637774
148Overgrowth (HP:0001548)1.73576785
149Cerebral aneurysm (HP:0004944)1.73482294
150Disinhibition (HP:0000734)1.73423616
151EEG with generalized epileptiform discharges (HP:0011198)1.72690764
152Thin bony cortex (HP:0002753)1.72391974
153Neoplasm of the heart (HP:0100544)1.71479630
154Enlarged penis (HP:0000040)1.70317229
155Clonus (HP:0002169)1.70304564
156Abnormality of the Achilles tendon (HP:0005109)1.69994393
157Hypsarrhythmia (HP:0002521)1.69801026
158Aplasia of the phalanges of the hand (HP:0009802)1.66646788
159Gait ataxia (HP:0002066)1.66539447
160Rigidity (HP:0002063)1.66434741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.17148628
2NTRK33.29436291
3EPHA43.19272034
4DAPK23.14005046
5MARK13.02890474
6PAK62.63973156
7CAMKK12.59526599
8KSR22.54437588
9PRKD32.50983424
10MINK12.46355870
11MAP3K42.38196347
12RIPK42.36342170
13RIPK12.15240958
14SIK22.07147914
15TRIB32.03974935
16SIK11.87829657
17NTRK11.86292108
18NTRK21.85894416
19DAPK11.78402170
20ERN11.67000902
21TAOK11.59993742
22STK381.57335637
23KSR11.55202117
24MAP2K71.54550949
25MAP2K41.54259289
26FES1.51645399
27TTN1.46126248
28TESK11.45891883
29TYRO31.45036373
30SMG11.43913831
31MAP3K131.42509722
32ALK1.40680290
33DDR21.38165145
34PRKCH1.37384911
35* CDK51.35076727
36MAP3K111.29726357
37PKN21.27618144
38CAMKK21.23612665
39RET1.16797463
40SCYL21.14706257
41MAP3K21.12722576
42MAP3K121.11653043
43GRK51.10032432
44STK111.07788095
45TAOK21.07229166
46PRPF4B1.05804360
47PTK21.05061327
48LATS21.00048513
49CDK120.99061097
50CDK190.92239280
51UHMK10.91617510
52PRKCG0.90315975
53MAPK130.90201554
54PLK20.89492843
55PRKG20.88737479
56CAMK10.87425577
57SGK30.86210327
58MARK20.84688886
59PDK10.83868834
60CAMK1G0.83778304
61IRAK30.80089873
62RAF10.80022194
63CDK150.79143571
64PAK20.77512422
65CDK180.77052239
66ARAF0.76781375
67EPHB20.76068041
68PHKG10.75505575
69PHKG20.75505575
70MOS0.74228330
71FGFR40.74196508
72MAP3K70.71987923
73MYLK0.70964941
74CDK11A0.70380257
75EEF2K0.69512001
76MAP3K10.69218189
77CDK140.69057349
78PDGFRA0.68932403
79LIMK10.68926341
80PDPK10.67808387
81EPHB10.67699325
82PTK2B0.67652547
83MTOR0.66687262
84MAP2K30.65913700
85ROCK20.65360307
86CAMK40.64645874
87CAMK1D0.63762000
88DMPK0.63484469
89CAMK2B0.62515589
90BMX0.59885884
91FYN0.59588017
92MAP3K100.59568102
93CDC42BPA0.59543612
94PAK30.58254818
95DAPK30.57294839
96RPS6KA20.57154964
97BRAF0.56669108
98MAPK70.56374114
99SGK10.55625199
100ROCK10.55267102
101SGK20.54962233
102TNK20.54041951
103MAP3K30.53967072
104LMTK20.53831332
105SGK4940.53167551
106SGK2230.53167551
107PDGFRB0.51580362
108NEK10.51268384
109TIE10.51184037
110RPS6KL10.50388925
111RPS6KC10.50388925
112ICK0.50031055
113MAP3K60.49799912
114TGFBR20.49395316
115PRKCZ0.49291489
116CAMK2G0.48439561
117HIPK20.47634334
118MAPK40.46023344
119RPS6KA30.45937619
120MAPK120.44636103
121PAK40.44574032
122HCK0.44237013
123CAMK2A0.42469342
124CSNK1G20.42359097
125GRK60.42006128
126SYK0.41921514
127PTK60.41906904
128DYRK1A0.41689659
129BRSK10.41155953
130JAK10.40572947
131PINK10.39725740
132MAPK100.39546400
133JAK20.39417287
134FGR0.38903956
135MAP2K10.38068949
136PRKD20.36587375
137MAPK80.31325295
138* SRC0.30693543

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.90370303
2Nicotine addiction_Homo sapiens_hsa050332.46684860
3Olfactory transduction_Homo sapiens_hsa047402.38676270
4Long-term potentiation_Homo sapiens_hsa047202.33445759
5Circadian entrainment_Homo sapiens_hsa047132.22623869
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21018209
7Glutamatergic synapse_Homo sapiens_hsa047242.11033229
8GABAergic synapse_Homo sapiens_hsa047272.00521790
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99605846
10Morphine addiction_Homo sapiens_hsa050321.99073747
11Amphetamine addiction_Homo sapiens_hsa050311.82991983
12Salivary secretion_Homo sapiens_hsa049701.81954469
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77770357
14Gastric acid secretion_Homo sapiens_hsa049711.75668503
15Dopaminergic synapse_Homo sapiens_hsa047281.73799264
16Cholinergic synapse_Homo sapiens_hsa047251.70858317
17Insulin secretion_Homo sapiens_hsa049111.67275700
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58077338
19Oxytocin signaling pathway_Homo sapiens_hsa049211.54207959
20Type II diabetes mellitus_Homo sapiens_hsa049301.49349216
21Glioma_Homo sapiens_hsa052141.46874871
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46446167
23Long-term depression_Homo sapiens_hsa047301.45474138
24GnRH signaling pathway_Homo sapiens_hsa049121.43054962
25Renin secretion_Homo sapiens_hsa049241.34481393
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31429066
27Estrogen signaling pathway_Homo sapiens_hsa049151.29884249
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28472483
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28396806
30Nitrogen metabolism_Homo sapiens_hsa009101.27006640
31Other glycan degradation_Homo sapiens_hsa005111.23265070
32Calcium signaling pathway_Homo sapiens_hsa040201.22226682
33Gap junction_Homo sapiens_hsa045401.21644133
34* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19408328
35Cocaine addiction_Homo sapiens_hsa050301.18985072
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.18954005
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.14608195
38* Focal adhesion_Homo sapiens_hsa045101.14556808
39cAMP signaling pathway_Homo sapiens_hsa040241.11792881
40Taste transduction_Homo sapiens_hsa047421.11714289
41ErbB signaling pathway_Homo sapiens_hsa040121.10604887
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07647649
43Notch signaling pathway_Homo sapiens_hsa043301.06904354
44VEGF signaling pathway_Homo sapiens_hsa043701.06325865
45Amoebiasis_Homo sapiens_hsa051461.05750141
46ECM-receptor interaction_Homo sapiens_hsa045121.04050799
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03572686
48* Phospholipase D signaling pathway_Homo sapiens_hsa040721.01111952
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00214817
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99850967
51Serotonergic synapse_Homo sapiens_hsa047260.99628312
52mTOR signaling pathway_Homo sapiens_hsa041500.98922711
53Dorso-ventral axis formation_Homo sapiens_hsa043200.98339314
54* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96072723
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94868805
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92130544
57Non-small cell lung cancer_Homo sapiens_hsa052230.90292197
58Melanogenesis_Homo sapiens_hsa049160.88652938
59Axon guidance_Homo sapiens_hsa043600.87681914
60Endometrial cancer_Homo sapiens_hsa052130.86540956
61B cell receptor signaling pathway_Homo sapiens_hsa046620.85906944
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85143894
63Collecting duct acid secretion_Homo sapiens_hsa049660.83657709
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83447948
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83368005
66Chemokine signaling pathway_Homo sapiens_hsa040620.83197726
67Acute myeloid leukemia_Homo sapiens_hsa052210.83136891
68Proteoglycans in cancer_Homo sapiens_hsa052050.82896457
69MAPK signaling pathway_Homo sapiens_hsa040100.81027924
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.81025255
71Bladder cancer_Homo sapiens_hsa052190.78967785
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78907506
73* Endocytosis_Homo sapiens_hsa041440.76773006
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73715663
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.71951964
76Pancreatic secretion_Homo sapiens_hsa049720.71762100
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.71602004
78Dilated cardiomyopathy_Homo sapiens_hsa054140.71522272
79Oocyte meiosis_Homo sapiens_hsa041140.70887606
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70727449
81Rap1 signaling pathway_Homo sapiens_hsa040150.70545078
82* Choline metabolism in cancer_Homo sapiens_hsa052310.70528861
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70214221
84Thyroid hormone synthesis_Homo sapiens_hsa049180.69763323
85Renal cell carcinoma_Homo sapiens_hsa052110.69575899
86Osteoclast differentiation_Homo sapiens_hsa043800.69116551
87* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68445440
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66432650
89Colorectal cancer_Homo sapiens_hsa052100.66343537
90Platelet activation_Homo sapiens_hsa046110.66278638
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65945632
92Vitamin B6 metabolism_Homo sapiens_hsa007500.65760022
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64899678
94Chronic myeloid leukemia_Homo sapiens_hsa052200.64316594
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62326604
96Prolactin signaling pathway_Homo sapiens_hsa049170.61710297
97Insulin signaling pathway_Homo sapiens_hsa049100.61189150
98HIF-1 signaling pathway_Homo sapiens_hsa040660.61050420
99Protein digestion and absorption_Homo sapiens_hsa049740.60920316
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60737011
101Tuberculosis_Homo sapiens_hsa051520.60348306
102AMPK signaling pathway_Homo sapiens_hsa041520.59543853
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58218415
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55641772
105Prion diseases_Homo sapiens_hsa050200.54983482
106Ras signaling pathway_Homo sapiens_hsa040140.54301363
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53593234
108Salmonella infection_Homo sapiens_hsa051320.52222009
109* Inositol phosphate metabolism_Homo sapiens_hsa005620.50973667
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50837787
111Glucagon signaling pathway_Homo sapiens_hsa049220.50497482
112T cell receptor signaling pathway_Homo sapiens_hsa046600.49944924
113Pancreatic cancer_Homo sapiens_hsa052120.48710826
114Vibrio cholerae infection_Homo sapiens_hsa051100.48087626
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.47585728
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46730441
117Bile secretion_Homo sapiens_hsa049760.45679715
118Lysosome_Homo sapiens_hsa041420.45448591

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