PIP5K1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.05218231
2COPI coating of Golgi vesicle (GO:0048205)5.05218231
3pore complex assembly (GO:0046931)4.62274631
4mitotic chromosome condensation (GO:0007076)4.29410351
5DNA unwinding involved in DNA replication (GO:0006268)4.08791377
6hemidesmosome assembly (GO:0031581)3.84190699
7regulation of mammary gland epithelial cell proliferation (GO:0033599)3.65533679
8regulation of RNA export from nucleus (GO:0046831)3.60919795
9mitotic sister chromatid cohesion (GO:0007064)3.56351258
10negative regulation of cell killing (GO:0031342)3.54418193
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54418193
12spliceosomal tri-snRNP complex assembly (GO:0000244)3.50859408
13paraxial mesoderm development (GO:0048339)3.44134505
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.43101258
15planar cell polarity pathway involved in neural tube closure (GO:0090179)3.42690753
16regulation of translational fidelity (GO:0006450)3.39290876
17* cell-substrate junction assembly (GO:0007044)3.35412219
18regulation of nucleobase-containing compound transport (GO:0032239)3.31208210
19protein retention in ER lumen (GO:0006621)3.30564315
20embryonic process involved in female pregnancy (GO:0060136)3.29101864
21protein localization to endosome (GO:0036010)3.28854471
22retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.28795187
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.28187672
24regulation of NFAT protein import into nucleus (GO:0051532)3.25523387
25cellular protein complex localization (GO:0034629)3.24543940
26protein complex localization (GO:0031503)3.09603424
27peptidyl-lysine dimethylation (GO:0018027)3.03302211
28wound healing, spreading of epidermal cells (GO:0035313)3.03020474
29desmosome organization (GO:0002934)3.01736817
30RNA stabilization (GO:0043489)2.90611564
31mRNA stabilization (GO:0048255)2.90611564
32mitotic sister chromatid segregation (GO:0000070)2.90545686
33protein export from nucleus (GO:0006611)2.88085470
34sister chromatid segregation (GO:0000819)2.85427505
35basement membrane organization (GO:0071711)2.80874980
36protein localization to chromosome, centromeric region (GO:0071459)2.80002597
37DNA duplex unwinding (GO:0032508)2.77273189
38negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.76512104
39protein localization to microtubule (GO:0035372)2.76420227
40chromosome condensation (GO:0030261)2.71909923
41heterochromatin organization (GO:0070828)2.71629965
42negative regulation of cell size (GO:0045792)2.71193472
43NLS-bearing protein import into nucleus (GO:0006607)2.70176068
44glucocorticoid receptor signaling pathway (GO:0042921)2.68884210
45mitotic nuclear envelope disassembly (GO:0007077)2.68728338
46vesicle coating (GO:0006901)2.67649169
47membrane disassembly (GO:0030397)2.65975485
48nuclear envelope disassembly (GO:0051081)2.65975485
49apoptotic process involved in morphogenesis (GO:0060561)2.64645176
50peptidyl-arginine omega-N-methylation (GO:0035247)2.64640391
51regulation of translational termination (GO:0006449)2.61641944
52activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60198327
53regulation of mitotic spindle organization (GO:0060236)2.59701251
54DNA geometric change (GO:0032392)2.57721856
55negative regulation of DNA repair (GO:0045738)2.55966644
56epithelial cell-cell adhesion (GO:0090136)2.55902955
57regulation of histone H3-K27 methylation (GO:0061085)2.54449492
58proline biosynthetic process (GO:0006561)2.54300374
59histone H2B ubiquitination (GO:0033523)2.54282472
60endoplasmic reticulum unfolded protein response (GO:0030968)2.54114921
61positive regulation of keratinocyte differentiation (GO:0045618)2.54027541
62positive regulation of nuclease activity (GO:0032075)2.53938417
63COPII vesicle coating (GO:0048208)2.53323985
64ER-nucleus signaling pathway (GO:0006984)2.52904074
65regulation of glucose import in response to insulin stimulus (GO:2001273)2.52360936
66regulation of chromatin binding (GO:0035561)2.50583595
67nucleosome disassembly (GO:0006337)2.50326369
68protein-DNA complex disassembly (GO:0032986)2.50326369
69NIK/NF-kappaB signaling (GO:0038061)2.49637700
70nuclear envelope organization (GO:0006998)2.49069856
71dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46314391
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.45195008
73embryonic eye morphogenesis (GO:0048048)2.43053299
74branching involved in mammary gland duct morphogenesis (GO:0060444)2.42654664
75notochord development (GO:0030903)2.42595373
76regulation of sister chromatid cohesion (GO:0007063)2.41924575
77positive regulation of blood vessel endothelial cell migration (GO:0043536)2.41870732
78activation of MAPKKK activity (GO:0000185)2.40647466
79establishment of apical/basal cell polarity (GO:0035089)2.39938137
80positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.39562818
81mitotic cytokinesis (GO:0000281)2.39252363
82maternal placenta development (GO:0001893)2.39074633
83trophectodermal cell differentiation (GO:0001829)2.38864075
84regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.38535759
853-UTR-mediated mRNA stabilization (GO:0070935)2.35421604
86mammary gland epithelial cell proliferation (GO:0033598)2.34316798
87cellular response to unfolded protein (GO:0034620)2.34211144
88regulation of nuclease activity (GO:0032069)2.32522196
89Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.32400256
90modulation by symbiont of host cellular process (GO:0044068)2.32169614
91DNA conformation change (GO:0071103)2.32117103
92morphogenesis of an epithelial sheet (GO:0002011)2.31327096
93positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.30237933
94regulation of T-helper 1 cell differentiation (GO:0045625)2.30170157
95mitotic G1 DNA damage checkpoint (GO:0031571)2.30119307
96positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.28823993
97substrate-dependent cell migration (GO:0006929)2.28094907
98negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.27521285
99positive regulation of vesicle fusion (GO:0031340)2.24001743
100signal complex assembly (GO:0007172)2.20071687
101positive regulation of chemokine biosynthetic process (GO:0045080)2.17257566
102chondrocyte proliferation (GO:0035988)2.16049886
103regulation of hippo signaling (GO:0035330)2.15851084
104regulation of early endosome to late endosome transport (GO:2000641)2.13874425
105regulation of transforming growth factor beta2 production (GO:0032909)2.12887634
106plasma membrane repair (GO:0001778)2.11022083
107nuclear pore complex assembly (GO:0051292)2.07168299
108G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.05514947
109wound healing, spreading of cells (GO:0044319)2.01086694
110histone mRNA catabolic process (GO:0071044)2.00419553
111dosage compensation (GO:0007549)1.98930378
112response to muramyl dipeptide (GO:0032495)1.97370148
113negative regulation by host of viral transcription (GO:0043922)1.96792263
114regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.95939897
115stress fiber assembly (GO:0043149)1.94274502
116cell adhesion mediated by integrin (GO:0033627)1.93238359
117cellular senescence (GO:0090398)1.92827202
118endodermal cell differentiation (GO:0035987)1.92351526
119negative regulation of fatty acid transport (GO:2000192)1.92110064
120regulation of interleukin-12 biosynthetic process (GO:0045075)1.90536549
121modulation by organism of defense response of other organism involved in symbiotic interaction (GO:01.90107085
122positive regulation by organism of defense response of other organism involved in symbiotic interact1.90107085
123modulation by symbiont of host immune response (GO:0052553)1.90107085
124positive regulation by symbiont of host defense response (GO:0052509)1.90107085
125modulation by symbiont of host defense response (GO:0052031)1.90107085
126modulation by organism of immune response of other organism involved in symbiotic interaction (GO:001.90107085
127positive regulation of endothelial cell apoptotic process (GO:2000353)1.89720998
128* adherens junction assembly (GO:0034333)1.88786198
129nuclear pore organization (GO:0006999)1.87892584
130positive regulation of gamma-delta T cell activation (GO:0046645)1.86899760
131cellular response to interferon-alpha (GO:0035457)1.86404742
132skin morphogenesis (GO:0043589)1.86128589
133natural killer cell mediated immunity (GO:0002228)1.84923431
134natural killer cell mediated cytotoxicity (GO:0042267)1.84923431
135regulation of syncytium formation by plasma membrane fusion (GO:0060142)1.84223929
136corticosteroid receptor signaling pathway (GO:0031958)1.81736278
137eosinophil chemotaxis (GO:0048245)1.80099678
138mesodermal cell differentiation (GO:0048333)1.79794193
139positive regulation of leukocyte apoptotic process (GO:2000108)1.79555048
140regulation of fibroblast apoptotic process (GO:2000269)1.78132117
141modulation by virus of host process (GO:0019054)1.77768676
142pre-miRNA processing (GO:0031054)1.77116131
143regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.76239367
144cellular response to interleukin-15 (GO:0071350)1.76132096
145Rap protein signal transduction (GO:0032486)1.75186154
146response to interleukin-15 (GO:0070672)1.73534124
147* cell-substrate adherens junction assembly (GO:0007045)1.73442497
148* focal adhesion assembly (GO:0048041)1.73442497
149myeloid dendritic cell differentiation (GO:0043011)1.73270295
150axon extension involved in axon guidance (GO:0048846)1.71689023
151neuron projection extension involved in neuron projection guidance (GO:1902284)1.71689023
152trophoblast giant cell differentiation (GO:0060707)1.71681083
153positive regulation of interleukin-2 biosynthetic process (GO:0045086)1.71145043
154peptidyl-arginine methylation (GO:0018216)1.70860003
155peptidyl-arginine N-methylation (GO:0035246)1.70860003
156regulation of G0 to G1 transition (GO:0070316)1.70812224
157regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)1.70080637
158SMAD protein complex assembly (GO:0007183)1.69648584
159regulation of transforming growth factor beta1 production (GO:0032908)1.69051270
160regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)1.68849306
161positive regulation of cardiac muscle cell differentiation (GO:2000727)1.68679608
162platelet aggregation (GO:0070527)1.68364639
163positive regulation of heat generation (GO:0031652)1.68024665
164regulation of clathrin-mediated endocytosis (GO:2000369)1.67193407
165regulation of MHC class I biosynthetic process (GO:0045343)1.66666047
166lipopolysaccharide-mediated signaling pathway (GO:0031663)1.66267701
167mRNA transcription (GO:0009299)1.66099919
168lens fiber cell differentiation (GO:0070306)1.65858004
169negative regulation of T cell receptor signaling pathway (GO:0050860)1.64524747
170monoubiquitinated protein deubiquitination (GO:0035520)1.64447047
171chromatin assembly (GO:0031497)1.63694536
172macrophage activation involved in immune response (GO:0002281)1.63666803
173regulation of integrin activation (GO:0033623)1.61688865
174T cell apoptotic process (GO:0070231)1.60974793
175regulation of tight junction assembly (GO:2000810)1.60477504
176positive regulation of fibroblast migration (GO:0010763)1.60275822
177placenta blood vessel development (GO:0060674)1.60158638
178regulation of chemokine-mediated signaling pathway (GO:0070099)1.58458919
179histone H2A monoubiquitination (GO:0035518)1.57916191
180glial cell proliferation (GO:0014009)1.57661751
181protein heterotrimerization (GO:0070208)1.57578408
182positive T cell selection (GO:0043368)1.56860039
183hippo signaling (GO:0035329)1.56737642
184regulation of posttranscriptional gene silencing (GO:0060147)1.56660665
185regulation of gene silencing by miRNA (GO:0060964)1.56660665
186regulation of gene silencing by RNA (GO:0060966)1.56660665

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human5.46016402
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.27957767
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.09351095
4E2F7_22180533_ChIP-Seq_HELA_Human3.05436921
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97590810
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.70683926
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.65720465
8AR_21909140_ChIP-Seq_LNCAP_Human2.31888886
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.24936442
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24627231
11CLOCK_20551151_ChIP-Seq_293T_Human2.22342199
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.17964101
13ZNF263_19887448_ChIP-Seq_K562_Human2.13910131
14MYC_22102868_ChIP-Seq_BL_Human2.08918021
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.05256726
16* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04195840
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99817706
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94032141
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.89759571
20IRF8_21731497_ChIP-ChIP_J774_Mouse1.89604594
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.84239905
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80633031
23KDM2B_26808549_Chip-Seq_DND41_Human1.80153230
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74319168
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72605367
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72586642
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69996451
28ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68657931
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63442384
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.63047643
31TCF7_22412390_ChIP-Seq_EML_Mouse1.61619183
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.60787302
33* ELK3_25401928_ChIP-Seq_HUVEC_Human1.58889129
34CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56913884
35KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56255590
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.55785623
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55229975
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54574338
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54497588
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53168242
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52939513
42TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52036516
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50601834
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50247168
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48981088
46XRN2_22483619_ChIP-Seq_HELA_Human1.48980108
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45245670
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43854787
49MAF_26560356_Chip-Seq_TH1_Human1.43427741
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.42798162
51BRD4_25478319_ChIP-Seq_HGPS_Human1.41687898
52* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40922748
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40852029
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38261235
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37584089
56* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37578244
57* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37578244
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36974674
59* ATF3_27146783_Chip-Seq_COLON_Human1.36669789
60* CHD1_26751641_Chip-Seq_LNCaP_Human1.36615554
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36478024
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34403702
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33575335
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32921753
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.32503616
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.32030969
67KDM2B_26808549_Chip-Seq_K562_Human1.30702974
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29812269
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29439002
70TP53_22127205_ChIP-Seq_IMR90_Human1.29118745
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28261561
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.27090450
73* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26714322
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26232809
75* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26097137
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25045214
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24244603
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23660059
79LXR_22292898_ChIP-Seq_THP-1_Human1.23455094
80NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23222186
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22105844
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.20631178
83* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19241698
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19049618
85* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19016965
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.18745048
87MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18318365
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16621944
89ELK1_22589737_ChIP-Seq_MCF10A_Human1.16481903
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16324064
91NANOG_21062744_ChIP-ChIP_HESCs_Human1.15181468
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14869238
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14608556
94UTX_26944678_Chip-Seq_JUKART_Human1.14121482
95* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13826652
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12805615
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11730624
98MYB_26560356_Chip-Seq_TH2_Human1.10845338
99SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09928780
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09920008
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09829684
102* KDM5A_27292631_Chip-Seq_BREAST_Human1.09189429
103RARB_27405468_Chip-Seq_BRAIN_Mouse1.08640380
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08407521
105* ELK1_19687146_ChIP-ChIP_HELA_Human1.08340413
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07615980
107NCOR1_26117541_ChIP-Seq_K562_Human1.06776132
108WT1_19549856_ChIP-ChIP_CCG9911_Human1.06362551
109ESR1_21235772_ChIP-Seq_MCF-7_Human1.06314437
110P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05448333
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05164835
112* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05129940
113* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04984396
114RUNX1_27514584_Chip-Seq_MCF-7_Human1.04462095
115MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03541929
116E2F1_21310950_ChIP-Seq_MCF-7_Human1.03212819
117* TFEB_21752829_ChIP-Seq_HELA_Human1.02949839
118DCP1A_22483619_ChIP-Seq_HELA_Human1.02000542
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01900136
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01900136
121KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01900136
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98830919
123SPI1_23127762_ChIP-Seq_K562_Human0.96981895
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96936394
125FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95698284
126* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95481841
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95385808
128THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95125353
129E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95064979
130RACK7_27058665_Chip-Seq_MCF-7_Human0.94711719
131CREB1_26743006_Chip-Seq_LNCaP_Human0.94133735
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94068978
133* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94064095
134FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93840189
135* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92730202
136MYB_26560356_Chip-Seq_TH1_Human0.92316782
137EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91878574
138CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91159390
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90406954
140PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90131992
141EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86529735
142VDR_21846776_ChIP-Seq_THP-1_Human0.85676900
143ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84890443
144TP53_18474530_ChIP-ChIP_U2OS_Human0.84830814
145BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83687893
146* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82811024
147GATA2_21666600_ChIP-Seq_HMVEC_Human0.82431286
148VDR_24763502_ChIP-Seq_THP-1_Human0.82243426
149ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81154551
150CJUN_26792858_Chip-Seq_BT549_Human0.80570896

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog2.96724338
2MP0003303_peritoneal_inflammation2.67282743
3MP0004233_abnormal_muscle_weight2.53146176
4MP0008438_abnormal_cutaneous_collagen2.35842240
5MP0005623_abnormal_meninges_morphology2.23457224
6MP0010234_abnormal_vibrissa_follicle2.14652524
7MP0003123_paternal_imprinting2.10140605
8MP0010352_gastrointestinal_tract_polyps2.08438954
9MP0005257_abnormal_intraocular_pressure2.04712521
10MP0004510_myositis2.03819553
11MP0003091_abnormal_cell_migration1.98503372
12MP0005451_abnormal_body_composition1.98056949
13MP0005076_abnormal_cell_differentiation1.93280005
14MP0004859_abnormal_synaptic_plasticity1.88467895
15MP0008007_abnormal_cellular_replicative1.77539481
16MP0000537_abnormal_urethra_morphology1.76678777
17MP0008057_abnormal_DNA_replication1.75099599
18MP0004808_abnormal_hematopoietic_stem1.70941401
19MP0010030_abnormal_orbit_morphology1.70645937
20MP0009053_abnormal_anal_canal1.70305887
21MP0003693_abnormal_embryo_hatching1.70210444
22MP0002060_abnormal_skin_morphology1.69656606
23MP0001849_ear_inflammation1.66677710
24MP0001730_embryonic_growth_arrest1.66229343
25MP0000858_altered_metastatic_potential1.63923010
26MP0002796_impaired_skin_barrier1.62927903
27MP0003705_abnormal_hypodermis_morpholog1.61752902
28MP0010094_abnormal_chromosome_stability1.61624484
29MP0009333_abnormal_splenocyte_physiolog1.61301268
30MP0003941_abnormal_skin_development1.59714510
31MP0004858_abnormal_nervous_system1.59584340
32MP0002009_preneoplasia1.58663951
33MP0003279_aneurysm1.57752042
34MP0008932_abnormal_embryonic_tissue1.53944524
35MP0000579_abnormal_nail_morphology1.53156415
36MP0005275_abnormal_skin_tensile1.52276878
37MP0003448_altered_tumor_morphology1.50650013
38MP0003566_abnormal_cell_adhesion1.48197093
39MP0010307_abnormal_tumor_latency1.47195565
40MP0005409_darkened_coat_color1.46652045
41MP0004264_abnormal_extraembryonic_tissu1.45435111
42MP0003453_abnormal_keratinocyte_physiol1.44215651
43MP0000733_abnormal_muscle_development1.43313778
44MP0005501_abnormal_skin_physiology1.42157891
45MP0000762_abnormal_tongue_morphology1.38135979
46MP0003787_abnormal_imprinting1.37259585
47MP0003436_decreased_susceptibility_to1.34648926
48MP0002697_abnormal_eye_size1.27894828
49MP0002148_abnormal_hypersensitivity_rea1.23495125
50MP0001346_abnormal_lacrimal_gland1.23380923
51MP0000350_abnormal_cell_proliferation1.21480636
52MP0002080_prenatal_lethality1.20744144
53MP0003942_abnormal_urinary_system1.20390919
54MP0000534_abnormal_ureter_morphology1.17638667
55MP0003950_abnormal_plasma_membrane1.16216278
56MP0005000_abnormal_immune_tolerance1.16070039
57MP0006082_CNS_inflammation1.15998075
58MP0003828_pulmonary_edema1.15163678
59MP0001216_abnormal_epidermal_layer1.14923777
60MP0003385_abnormal_body_wall1.12807884
61MP0009672_abnormal_birth_weight1.12470995
62MP0005503_abnormal_tendon_morphology1.10621620
63MP0004272_abnormal_basement_membrane1.06886242
64MP0002405_respiratory_system_inflammati1.06034406
65MP0000428_abnormal_craniofacial_morphol1.05887001
66MP0009384_cardiac_valve_regurgitation1.05614479
67MP0005248_abnormal_Harderian_gland1.05073707
68MP0003077_abnormal_cell_cycle1.05033961
69MP0002092_abnormal_eye_morphology1.04198424
70MP0000467_abnormal_esophagus_morphology1.01946943
71MP0005375_adipose_tissue_phenotype1.01762796
72MP0002398_abnormal_bone_marrow0.99685670
73MP0002098_abnormal_vibrissa_morphology0.99680970
74MP0002396_abnormal_hematopoietic_system0.99389428
75MP0000750_abnormal_muscle_regeneration0.98988891
76MP0004957_abnormal_blastocyst_morpholog0.98877654
77MP0003111_abnormal_nucleus_morphology0.98794710
78MP0000759_abnormal_skeletal_muscle0.97888706
79MP0005621_abnormal_cell_physiology0.97217846
80MP0003121_genomic_imprinting0.96819002
81MP0000767_abnormal_smooth_muscle0.94462971
82MP0002006_tumorigenesis0.94428025
83MP0005310_abnormal_salivary_gland0.94202707
84MP0000377_abnormal_hair_follicle0.93596478
85MP0000703_abnormal_thymus_morphology0.93470177
86MP0002163_abnormal_gland_morphology0.93270435
87MP0000685_abnormal_immune_system0.93178020
88MP0001661_extended_life_span0.93092285
89MP0003221_abnormal_cardiomyocyte_apopto0.92251324
90MP0004197_abnormal_fetal_growth/weight/0.91668996
91MP0003045_fibrosis0.90524482
92MP0005023_abnormal_wound_healing0.89986842
93MP0003935_abnormal_craniofacial_develop0.89821566
94MP0003122_maternal_imprinting0.89642318
95MP0001299_abnormal_eye_distance/0.89611767
96MP0010630_abnormal_cardiac_muscle0.88396996
97MP0001188_hyperpigmentation0.88095144
98MP0005508_abnormal_skeleton_morphology0.88091533
99MP0002086_abnormal_extraembryonic_tissu0.87825023
100MP0002089_abnormal_postnatal_growth/wei0.87568887
101MP0008260_abnormal_autophagy0.87347471
102MP0005390_skeleton_phenotype0.86575717
103MP0002452_abnormal_antigen_presenting0.86459047
104MP0002896_abnormal_bone_mineralization0.85863259
105MP0001819_abnormal_immune_cell0.85034811
106MP0001533_abnormal_skeleton_physiology0.83256918
107MP0002420_abnormal_adaptive_immunity0.82773118
108MP0002723_abnormal_immune_serum0.82729075
109MP0004947_skin_inflammation0.82710849
110MP0003763_abnormal_thymus_physiology0.82017909
111MP0005197_abnormal_uvea_morphology0.81574138
112MP0004782_abnormal_surfactant_physiolog0.81327116
113MP0005397_hematopoietic_system_phenotyp0.80754516
114MP0001545_abnormal_hematopoietic_system0.80754516
115MP0005666_abnormal_adipose_tissue0.80229531
116MP0005380_embryogenesis_phenotype0.80195670
117MP0001672_abnormal_embryogenesis/_devel0.80195670
118MP0010678_abnormal_skin_adnexa0.79887217
119MP0003937_abnormal_limbs/digits/tail_de0.79676976
120MP0005387_immune_system_phenotype0.79521561
121MP0001790_abnormal_immune_system0.79521561
122MP0001340_abnormal_eyelid_morphology0.79505369
123MP0002925_abnormal_cardiovascular_devel0.79418438
124MP0001958_emphysema0.79408317
125MP0004087_abnormal_muscle_fiber0.79354845
126MP0005671_abnormal_response_to0.79172289
127MP0003879_abnormal_hair_cell0.77923560
128MP0002269_muscular_atrophy0.77585568
129MP0001348_abnormal_lacrimal_gland0.76663131
130MP0001697_abnormal_embryo_size0.76035464
131MP0003984_embryonic_growth_retardation0.75671044
132MP0002998_abnormal_bone_remodeling0.75605322
133MP0002088_abnormal_embryonic_growth/wei0.75029692
134MP0002084_abnormal_developmental_patter0.74990769
135MP0003755_abnormal_palate_morphology0.74658207
136MP0000627_abnormal_mammary_gland0.73468818
137MP0009278_abnormal_bone_marrow0.73056635
138MP0009785_altered_susceptibility_to0.72923842
139MP0002177_abnormal_outer_ear0.72863854
140MP0001915_intracranial_hemorrhage0.72025559
141MP0005384_cellular_phenotype0.68426972
142MP0000716_abnormal_immune_system0.68125799
143MP0000490_abnormal_crypts_of0.67928243
144MP0002933_joint_inflammation0.67441790
145MP0001800_abnormal_humoral_immune0.66686974
146MP0003300_gastrointestinal_ulcer0.66613543
147MP0004185_abnormal_adipocyte_glucose0.65915157
148MP0000432_abnormal_head_morphology0.65531587
149MP0002085_abnormal_embryonic_tissue0.64175020
150MP0010386_abnormal_urinary_bladder0.64068809
151MP0003115_abnormal_respiratory_system0.63302654
152MP0002722_abnormal_immune_system0.62719216
153MP0000003_abnormal_adipose_tissue0.62451167
154MP0002419_abnormal_innate_immunity0.61571253

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.62126219
2Protrusio acetabuli (HP:0003179)3.24027672
3Asymmetry of the thorax (HP:0001555)3.20340574
4Premature rupture of membranes (HP:0001788)3.06625516
5Cerebral aneurysm (HP:0004944)2.88349525
6Abnormality of the distal phalanx of the thumb (HP:0009617)2.72287082
7Ulnar bowing (HP:0003031)2.64431057
8Stomatitis (HP:0010280)2.62869758
9Dilatation of the ascending aorta (HP:0005111)2.60242927
10Sparse lateral eyebrow (HP:0005338)2.58103842
11Flat acetabular roof (HP:0003180)2.57901947
12Prostate neoplasm (HP:0100787)2.45007563
13Distal lower limb amyotrophy (HP:0008944)2.44574302
14Shallow orbits (HP:0000586)2.42099175
15Syringomyelia (HP:0003396)2.38422015
16Spinal cord lesions (HP:0100561)2.38422015
17Absent frontal sinuses (HP:0002688)2.36646739
18Abnormality of the phalanges of the hallux (HP:0010057)2.34701300
19Peritonitis (HP:0002586)2.33977031
20Abnormality of the distal phalanges of the toes (HP:0010182)2.29849688
21Increased density of long bones (HP:0006392)2.26931658
22Insomnia (HP:0100785)2.23327755
23Deviation of the thumb (HP:0009603)2.22632910
24Aortic dissection (HP:0002647)2.22231182
25Porencephaly (HP:0002132)2.20774266
26Bladder diverticulum (HP:0000015)2.20742536
27Abnormality of the nasal septum (HP:0000419)2.16644745
28Deep philtrum (HP:0002002)2.15749229
29Achilles tendon contracture (HP:0001771)2.15657835
30Genu recurvatum (HP:0002816)2.15624790
31Selective tooth agenesis (HP:0001592)2.14717170
32Spinal rigidity (HP:0003306)2.14101616
33Atrophic scars (HP:0001075)2.13836357
34Ankle contracture (HP:0006466)2.12952457
35Advanced eruption of teeth (HP:0006288)2.11668274
36Vertebral compression fractures (HP:0002953)2.09339081
37Renal duplication (HP:0000075)2.08174726
38Vertebral arch anomaly (HP:0008438)2.06444077
39Disproportionate tall stature (HP:0001519)2.05667341
40Subacute progressive viral hepatitis (HP:0006572)2.05355063
41Lower limb amyotrophy (HP:0007210)2.04648546
42Wrist flexion contracture (HP:0001239)2.03329136
43Vascular tortuosity (HP:0004948)2.01749572
44Proximal placement of thumb (HP:0009623)2.00662404
45Aortic aneurysm (HP:0004942)1.98451257
46Cervical subluxation (HP:0003308)1.97678050
47Abnormality of the calcaneus (HP:0008364)1.97378090
48Pelvic girdle muscle weakness (HP:0003749)1.97188797
49Long palpebral fissure (HP:0000637)1.95266363
50Osteolytic defects of the hand bones (HP:0009699)1.94774187
51Osteolytic defects of the phalanges of the hand (HP:0009771)1.94774187
52Termporal pattern (HP:0011008)1.93229821
53Insidious onset (HP:0003587)1.93229821
54Overriding aorta (HP:0002623)1.92344872
55Dysmetric saccades (HP:0000641)1.90394870
56Mitral regurgitation (HP:0001653)1.89399153
57Back pain (HP:0003418)1.89009492
58Elbow flexion contracture (HP:0002987)1.88711552
59Increased nuchal translucency (HP:0010880)1.88068004
60Persistence of primary teeth (HP:0006335)1.87842735
61Long eyelashes (HP:0000527)1.86772418
62Abnormality of the Achilles tendon (HP:0005109)1.85322418
63Micronodular cirrhosis (HP:0001413)1.84278526
64Abnormality of dentin (HP:0010299)1.84264828
65Ankyloglossia (HP:0010296)1.84167270
66Overlapping toe (HP:0001845)1.83921727
67Patellar dislocation (HP:0002999)1.83603804
68Arterial tortuosity (HP:0005116)1.82199494
69Elfin facies (HP:0004428)1.80868353
70Gastrointestinal infarctions (HP:0005244)1.79916711
71Mediastinal lymphadenopathy (HP:0100721)1.79635506
72Difficulty climbing stairs (HP:0003551)1.79405355
73Distal upper limb amyotrophy (HP:0007149)1.79019280
74Upper limb amyotrophy (HP:0009129)1.79019280
75Heterotopia (HP:0002282)1.78941552
76Pulmonary infiltrates (HP:0002113)1.78584589
77Right ventricular cardiomyopathy (HP:0011663)1.78355929
78High anterior hairline (HP:0009890)1.75652394
79Mitral valve prolapse (HP:0001634)1.75436894
80Renovascular hypertension (HP:0100817)1.75391499
81Decreased subcutaneous fat (HP:0001002)1.75232809
82Broad face (HP:0000283)1.74805209
83Abnormality of nail color (HP:0100643)1.74085099
84Abnormality of the acetabulum (HP:0003170)1.72557749
85Relative macrocephaly (HP:0004482)1.72362890
86Blue sclerae (HP:0000592)1.72046437
87Abnormality of the musculature of the pelvis (HP:0001469)1.71079253
88Abnormality of the hip-girdle musculature (HP:0001445)1.71079253
89Mildly elevated creatine phosphokinase (HP:0008180)1.70289844
90Eczematoid dermatitis (HP:0000976)1.69785128
91Shoulder girdle muscle weakness (HP:0003547)1.69708891
92Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69549853
93Biconcave vertebral bodies (HP:0004586)1.69540568
94Wormian bones (HP:0002645)1.69502671
95Centrally nucleated skeletal muscle fibers (HP:0003687)1.68736150
96Arnold-Chiari malformation (HP:0002308)1.68727185
97Distal lower limb muscle weakness (HP:0009053)1.67890046
98Entropion (HP:0000621)1.66783017
99Abnormal ossification of hand bones (HP:0005921)1.66746768
100Abnormality of oral frenula (HP:0000190)1.65986832
101Cubitus valgus (HP:0002967)1.64050154
102Progressive muscle weakness (HP:0003323)1.63239683
103Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.62000621
104Focal motor seizures (HP:0011153)1.61727354
105Abnormality of the radial head (HP:0003995)1.60620240
106Fused cervical vertebrae (HP:0002949)1.60583764
107Pointed chin (HP:0000307)1.60502704
108Poikiloderma (HP:0001029)1.60416985
109Elevated erythrocyte sedimentation rate (HP:0003565)1.60091623
110Pterygium (HP:0001059)1.59013917
111Abnormality of the umbilical cord (HP:0010881)1.58971480
112Flat cornea (HP:0007720)1.58621257
113Limited elbow extension (HP:0001377)1.58507239
114Type 1 muscle fiber predominance (HP:0003803)1.58506504
115Long toe (HP:0010511)1.57581306
116Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57377342
117Chromsome breakage (HP:0040012)1.55271572
118Deviation of the hallux (HP:0010051)1.53942460
119Radial bowing (HP:0002986)1.53235036
120Joint laxity (HP:0001388)1.53124772
121Delayed cranial suture closure (HP:0000270)1.52794795
122Renal cell carcinoma (HP:0005584)1.52633796
123Hallux valgus (HP:0001822)1.52526775
124Autoimmune thrombocytopenia (HP:0001973)1.51319176
125Viral hepatitis (HP:0006562)1.50937165
126Somatic mutation (HP:0001428)1.50470102
127Bladder neoplasm (HP:0009725)1.50293260
128Bladder carcinoma (HP:0002862)1.50293260
129Submucous cleft hard palate (HP:0000176)1.49979038
130Leiomyosarcoma (HP:0100243)1.49102844
131Uterine leiomyosarcoma (HP:0002891)1.49102844
132Soft skin (HP:0000977)1.49019132
133Abnormality of the peritoneum (HP:0002585)1.48423504
134Thoracolumbar scoliosis (HP:0002944)1.47902469
135Increased connective tissue (HP:0009025)1.47870265
136Bicuspid aortic valve (HP:0001647)1.47426963
137Subaortic stenosis (HP:0001682)1.45872672
138Abnormality of the left ventricular outflow tract (HP:0011103)1.45872672
139Aneurysm (HP:0002617)1.45755532
140Myositis (HP:0100614)1.45396392
141Leukocytosis (HP:0001974)1.44189497
142Arterial thrombosis (HP:0004420)1.44176873
143Fragile skin (HP:0001030)1.44105988
144Spinal cord compression (HP:0002176)1.43798405
145Obstructive lung disease (HP:0006536)1.43721117
146Chronic obstructive pulmonary disease (HP:0006510)1.43721117
147Increased IgM level (HP:0003496)1.41755178
148Natal tooth (HP:0000695)1.41748088
149Facial hemangioma (HP:0000329)1.40682241
150Deep palmar crease (HP:0006191)1.39893270
151Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.39179968
152Apathy (HP:0000741)1.37221755
153Capillary hemangiomas (HP:0005306)1.36562139
154Atonic seizures (HP:0010819)1.36373654
155Transitional cell carcinoma of the bladder (HP:0006740)1.36187232
156Complete atrioventricular canal defect (HP:0001674)1.36141232
157Milia (HP:0001056)1.35915282
158Abnormality of the aortic arch (HP:0012303)1.35557734
159Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.34749216
160Chest pain (HP:0100749)1.34632532
161Recurrent viral infections (HP:0004429)1.34425399
162Retrobulbar optic neuritis (HP:0100654)1.34245927
163Optic neuritis (HP:0100653)1.34245927
164Spinal muscular atrophy (HP:0007269)1.33192617
165Short nail (HP:0001799)1.33168624
166Slender long bone (HP:0003100)1.33140209
167Acrocyanosis (HP:0001063)1.33068060
168Dislocated radial head (HP:0003083)1.32668021
169Myopathic facies (HP:0002058)1.32378933
170Trismus (HP:0000211)1.32158131
171Recurrent fungal infections (HP:0002841)1.31976017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.33228900
2SMG13.27041015
3ICK3.04750195
4RPS6KA42.44830390
5CDK122.32270512
6TRIB32.31869663
7NME22.19975291
8SIK12.19337022
9EPHA22.15705066
10KSR22.10137352
11BMX2.05902928
12PDGFRA1.97971437
13BRD41.95990479
14MAP3K141.92695887
15DDR21.86610083
16MKNK21.85925528
17MST1R1.80187211
18TTN1.77465494
19MET1.66442493
20RIPK11.61129434
21TAOK21.61034400
22FGFR41.59211055
23NTRK31.59024202
24MTOR1.52082448
25ALK1.51303835
26NTRK11.48521542
27PLK21.47025001
28EPHA41.46323321
29MAP3K111.45853108
30MAP3K121.45350927
31MST41.43204269
32MAP2K31.37240122
33PKN21.35917401
34TAOK11.35431017
35PTK2B1.34501833
36MAP3K101.34418182
37RPS6KB21.33653500
38JAK31.33618962
39CHUK1.26255667
40DMPK1.24366427
41ERN11.24037112
42PRPF4B1.18594177
43IKBKB1.18316441
44PIM21.17166091
45MAP3K31.15362830
46MOS1.13202442
47CAMK1D1.12381326
48CDK71.10090992
49ERBB41.09656649
50LATS21.08293385
51STK31.08047496
52AKT31.07918951
53MAP3K131.06248628
54PRKD21.05077131
55PDGFRB1.04477874
56RAF11.02788594
57CAMK1G1.01971493
58IRAK31.01152659
59TBK11.00917524
60SIK20.99654990
61MARK30.97915943
62MAP3K50.97321393
63TTK0.93524653
64TRPM70.92479394
65FER0.91499919
66CLK10.91171956
67SRPK10.89661982
68KSR10.87924391
69CAMKK10.87913058
70PTK20.87252767
71NEK90.87181257
72PASK0.86525561
73MAP3K80.84904842
74TXK0.84831063
75CDC70.83448967
76PAK60.82905263
77SIK30.81812153
78MAP3K20.81412952
79EPHB10.80786331
80MAP3K10.79761454
81MELK0.77488467
82CHEK20.77272810
83STK100.76865502
84PAK40.76811237
85CDK60.74537121
86STK240.74162239
87NME10.73864394
88FLT30.72917941
89PRKD30.72716455
90TSSK60.72546525
91HCK0.72151541
92NEK20.71117020
93NEK10.70980653
94CHEK10.70323705
95PIM10.70135291
96CDK80.68853991
97TYRO30.68392989
98MKNK10.68034499
99CSK0.68009343
100STK40.67091204
101STK380.66691610
102ARAF0.66655206
103RPS6KA20.65662726
104MAP2K10.65108958
105BRAF0.64431664
106ABL20.63829061
107FES0.63141990
108BMPR20.63074969
109MAPK110.60374858
110LATS10.59893147
111AKT20.59782722
112CDC42BPA0.59644656
113EEF2K0.59610731
114NLK0.59538678
115SGK20.59045693
116PAK20.58505752
117MARK20.58076476
118PBK0.57941186
119PLK30.57678507
120EIF2AK10.57546639
121PAK30.56498472
122AURKB0.54868663
123ZAP700.53565549
124IKBKE0.51932888
125BUB10.51830641
126SGK30.51044921
127MAP2K20.50425209
128LRRK20.50030229
129CDK40.49720621
130BRSK20.48668240
131RPS6KL10.47104865
132RPS6KC10.47104865
133MAP3K60.46195105
134PTK60.45956084
135SCYL20.44352404
136TESK10.43320627
137FGR0.42369090
138MAP3K90.41622840
139CDK90.41363219
140BRSK10.41264773
141CDK20.41079477
142SGK10.40688566
143DAPK30.39683132
144INSR0.38926633
145PRKCH0.38717260
146CDK10.38407738
147ABL10.38166018
148ATR0.38165191
149LCK0.37812160
150STK38L0.36379225
151TAF10.35942913
152AURKA0.34969871
153RET0.34105832

Predicted pathways (KEGG)

RankGene SetZ-score
1Central carbon metabolism in cancer_Homo sapiens_hsa052301.87079535
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77441792
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.63051571
4DNA replication_Homo sapiens_hsa030301.46479373
5Notch signaling pathway_Homo sapiens_hsa043301.46213343
6Lysine degradation_Homo sapiens_hsa003101.45437430
7Chronic myeloid leukemia_Homo sapiens_hsa052201.30839486
8mRNA surveillance pathway_Homo sapiens_hsa030151.30625031
9Leishmaniasis_Homo sapiens_hsa051401.29987893
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26727159
11Glioma_Homo sapiens_hsa052141.23320461
12Biosynthesis of amino acids_Homo sapiens_hsa012301.22330286
13TNF signaling pathway_Homo sapiens_hsa046681.17739704
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16347207
15Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16300537
16Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16287006
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15872850
18Insulin signaling pathway_Homo sapiens_hsa049101.14195373
19Osteoclast differentiation_Homo sapiens_hsa043801.13247265
20Graft-versus-host disease_Homo sapiens_hsa053321.12891179
21Long-term potentiation_Homo sapiens_hsa047201.12608636
22RNA transport_Homo sapiens_hsa030131.12594422
23Shigellosis_Homo sapiens_hsa051311.12329046
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.08245303
25Bladder cancer_Homo sapiens_hsa052191.05479953
26MicroRNAs in cancer_Homo sapiens_hsa052061.03699422
27Type I diabetes mellitus_Homo sapiens_hsa049401.03578633
28Hepatitis B_Homo sapiens_hsa051611.02104116
29Pentose phosphate pathway_Homo sapiens_hsa000301.01948616
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01620235
31Focal adhesion_Homo sapiens_hsa045101.00729003
32Small cell lung cancer_Homo sapiens_hsa052221.00226856
33Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99765129
34AMPK signaling pathway_Homo sapiens_hsa041520.99598109
35Proteoglycans in cancer_Homo sapiens_hsa052050.97937022
36Adherens junction_Homo sapiens_hsa045200.97934325
37Neurotrophin signaling pathway_Homo sapiens_hsa047220.97033839
38T cell receptor signaling pathway_Homo sapiens_hsa046600.96135633
39Spliceosome_Homo sapiens_hsa030400.95995734
40Rheumatoid arthritis_Homo sapiens_hsa053230.94505460
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94488234
42Salmonella infection_Homo sapiens_hsa051320.94472928
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94418566
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94226514
45Prolactin signaling pathway_Homo sapiens_hsa049170.94191326
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93902175
47Amoebiasis_Homo sapiens_hsa051460.93517655
48p53 signaling pathway_Homo sapiens_hsa041150.93315345
49Acute myeloid leukemia_Homo sapiens_hsa052210.92448053
50Allograft rejection_Homo sapiens_hsa053300.92357753
51VEGF signaling pathway_Homo sapiens_hsa043700.92155714
52Non-small cell lung cancer_Homo sapiens_hsa052230.92143406
53Prion diseases_Homo sapiens_hsa050200.91999334
54Prostate cancer_Homo sapiens_hsa052150.91974609
55Renal cell carcinoma_Homo sapiens_hsa052110.91684905
56GnRH signaling pathway_Homo sapiens_hsa049120.90989894
57Measles_Homo sapiens_hsa051620.90985389
58N-Glycan biosynthesis_Homo sapiens_hsa005100.90149938
59Tuberculosis_Homo sapiens_hsa051520.89610788
60HTLV-I infection_Homo sapiens_hsa051660.88286713
61Pancreatic cancer_Homo sapiens_hsa052120.88274698
62Thyroid cancer_Homo sapiens_hsa052160.87805632
63Pathways in cancer_Homo sapiens_hsa052000.87431128
64mTOR signaling pathway_Homo sapiens_hsa041500.86641108
65Endometrial cancer_Homo sapiens_hsa052130.86352093
66Toxoplasmosis_Homo sapiens_hsa051450.85829575
67ErbB signaling pathway_Homo sapiens_hsa040120.85374531
68Hepatitis C_Homo sapiens_hsa051600.85179118
69HIF-1 signaling pathway_Homo sapiens_hsa040660.85052452
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84883443
71Oxytocin signaling pathway_Homo sapiens_hsa049210.84417872
72Influenza A_Homo sapiens_hsa051640.83039871
73B cell receptor signaling pathway_Homo sapiens_hsa046620.82398594
74Malaria_Homo sapiens_hsa051440.82208260
75Estrogen signaling pathway_Homo sapiens_hsa049150.82035742
76Basal cell carcinoma_Homo sapiens_hsa052170.81916748
77Colorectal cancer_Homo sapiens_hsa052100.81915979
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.81630173
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.81385540
80ECM-receptor interaction_Homo sapiens_hsa045120.81004774
81Chemokine signaling pathway_Homo sapiens_hsa040620.80975524
82Other glycan degradation_Homo sapiens_hsa005110.80677215
83Apoptosis_Homo sapiens_hsa042100.80302512
84Amphetamine addiction_Homo sapiens_hsa050310.80167734
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80156873
86MAPK signaling pathway_Homo sapiens_hsa040100.80077776
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79584621
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78978449
89Platelet activation_Homo sapiens_hsa046110.78692539
90* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77661920
91Melanoma_Homo sapiens_hsa052180.77355774
92Cell cycle_Homo sapiens_hsa041100.77304481
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77224266
94Legionellosis_Homo sapiens_hsa051340.76382645
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76202178
96Hematopoietic cell lineage_Homo sapiens_hsa046400.76111479
97Nucleotide excision repair_Homo sapiens_hsa034200.75950982
98* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75651649
99Dilated cardiomyopathy_Homo sapiens_hsa054140.75618057
100One carbon pool by folate_Homo sapiens_hsa006700.74702253
101TGF-beta signaling pathway_Homo sapiens_hsa043500.74612663
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.74012928
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73711863
104Herpes simplex infection_Homo sapiens_hsa051680.73054825
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72627365
106Cholinergic synapse_Homo sapiens_hsa047250.72514490
107Insulin resistance_Homo sapiens_hsa049310.72045436
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71942268
109Epstein-Barr virus infection_Homo sapiens_hsa051690.71742591
110FoxO signaling pathway_Homo sapiens_hsa040680.71659090
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71570028
112Olfactory transduction_Homo sapiens_hsa047400.71506166
113Viral carcinogenesis_Homo sapiens_hsa052030.71132570
114Long-term depression_Homo sapiens_hsa047300.70905179
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69824147
116Synaptic vesicle cycle_Homo sapiens_hsa047210.69814884
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69343396
118Hippo signaling pathway_Homo sapiens_hsa043900.68229162
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68029560
120Circadian entrainment_Homo sapiens_hsa047130.67517785
121Tight junction_Homo sapiens_hsa045300.67441947
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67339869
123Cocaine addiction_Homo sapiens_hsa050300.67160679
124Non-homologous end-joining_Homo sapiens_hsa034500.66999855
125Melanogenesis_Homo sapiens_hsa049160.66679411
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66523704
127Viral myocarditis_Homo sapiens_hsa054160.65753829
128* Inositol phosphate metabolism_Homo sapiens_hsa005620.65645598
129Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65278773
130Dopaminergic synapse_Homo sapiens_hsa047280.65079737
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64321090
132Wnt signaling pathway_Homo sapiens_hsa043100.64254804
133Antigen processing and presentation_Homo sapiens_hsa046120.63209806
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63185672
135Rap1 signaling pathway_Homo sapiens_hsa040150.62944801
136Nicotine addiction_Homo sapiens_hsa050330.62778888
137Dorso-ventral axis formation_Homo sapiens_hsa043200.62749462
138* Choline metabolism in cancer_Homo sapiens_hsa052310.62320438
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.60578512
140Hedgehog signaling pathway_Homo sapiens_hsa043400.60469991
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59628450
142Glucagon signaling pathway_Homo sapiens_hsa049220.58781982
143Axon guidance_Homo sapiens_hsa043600.58644501
144Base excision repair_Homo sapiens_hsa034100.57559805
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.57087325
146* Phospholipase D signaling pathway_Homo sapiens_hsa040720.54364182
147Vibrio cholerae infection_Homo sapiens_hsa051100.53966205

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