PINLYP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)7.99063147
2peptide cross-linking (GO:0018149)7.40066843
3regulation of water loss via skin (GO:0033561)7.29209500
4virion attachment to host cell (GO:0019062)7.28509244
5adhesion of symbiont to host cell (GO:0044650)7.28509244
6citrulline biosynthetic process (GO:0019240)7.15436128
7hair follicle morphogenesis (GO:0031069)6.71469622
8keratinocyte differentiation (GO:0030216)6.54221968
9intermediate filament cytoskeleton organization (GO:0045104)6.06803733
10epidermis development (GO:0008544)5.93430598
11adhesion of symbiont to host (GO:0044406)5.92501641
12intermediate filament-based process (GO:0045103)5.91835035
13bundle of His cell to Purkinje myocyte communication (GO:0086069)5.54916573
14epidermal cell differentiation (GO:0009913)5.13256227
15positive regulation of hair cycle (GO:0042635)5.11588399
16positive regulation of hair follicle development (GO:0051798)5.11588399
17keratinocyte development (GO:0003334)5.11051541
18skin morphogenesis (GO:0043589)5.01081947
19cell wall macromolecule metabolic process (GO:0044036)4.97589492
20cell wall macromolecule catabolic process (GO:0016998)4.97589492
21multicellular organismal water homeostasis (GO:0050891)4.85516367
22negative regulation of keratinocyte proliferation (GO:0010839)4.60946096
23behavioral response to nicotine (GO:0035095)4.54565593
24hemidesmosome assembly (GO:0031581)4.51463108
25hair cycle process (GO:0022405)4.37748709
26molting cycle process (GO:0022404)4.37748709
27citrulline metabolic process (GO:0000052)4.37506206
28phosphatidylinositol acyl-chain remodeling (GO:0036149)4.33861588
29water homeostasis (GO:0030104)4.22479240
30regulation of keratinocyte differentiation (GO:0045616)4.19356157
31regulation of hair follicle development (GO:0051797)4.14764867
32peptidyl-arginine modification (GO:0018195)4.14052174
33positive regulation of epidermis development (GO:0045684)4.13194536
34response to pheromone (GO:0019236)4.00237839
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.98886395
36platelet dense granule organization (GO:0060155)3.93535262
37tryptophan catabolic process (GO:0006569)3.89198005
38indole-containing compound catabolic process (GO:0042436)3.89198005
39indolalkylamine catabolic process (GO:0046218)3.89198005
40phosphatidylserine acyl-chain remodeling (GO:0036150)3.79920979
41DNA deamination (GO:0045006)3.75053345
42sphingosine metabolic process (GO:0006670)3.71823429
43indolalkylamine metabolic process (GO:0006586)3.71802381
44interferon-gamma secretion (GO:0072643)3.71349181
45regulation of cardioblast differentiation (GO:0051890)3.70722954
46fucose catabolic process (GO:0019317)3.62408357
47L-fucose metabolic process (GO:0042354)3.62408357
48L-fucose catabolic process (GO:0042355)3.62408357
49protein complex biogenesis (GO:0070271)3.61029632
50regulation of epidermis development (GO:0045682)3.58953264
51epithelial cilium movement (GO:0003351)3.58248952
52intestinal epithelial cell development (GO:0060576)3.53718564
53kynurenine metabolic process (GO:0070189)3.51910431
54respiratory chain complex IV assembly (GO:0008535)3.48967788
55water-soluble vitamin biosynthetic process (GO:0042364)3.45573023
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.44071518
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.44071518
58NADH dehydrogenase complex assembly (GO:0010257)3.44071518
59ectoderm development (GO:0007398)3.41967939
60positive regulation of epidermal cell differentiation (GO:0045606)3.40245902
61regulation of epidermal cell differentiation (GO:0045604)3.36903796
62phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.35272237
63regulation of hair cycle (GO:0042634)3.33395076
64tryptophan metabolic process (GO:0006568)3.33375000
65diol metabolic process (GO:0034311)3.32283026
66epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32275129
67mitochondrial respiratory chain complex assembly (GO:0033108)3.31271254
68axoneme assembly (GO:0035082)3.28383401
69sphingoid metabolic process (GO:0046519)3.26050894
70cytochrome complex assembly (GO:0017004)3.25579227
71detection of light stimulus involved in visual perception (GO:0050908)3.23371922
72detection of light stimulus involved in sensory perception (GO:0050962)3.23371922
73protein-cofactor linkage (GO:0018065)3.21187926
74negative regulation of telomere maintenance (GO:0032205)3.18143356
75regulation of transforming growth factor beta2 production (GO:0032909)3.16927267
76phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.15637431
77neural tube formation (GO:0001841)3.10442341
78DNA double-strand break processing (GO:0000729)3.10205710
79cellular ketone body metabolic process (GO:0046950)3.09989070
80cilium movement (GO:0003341)3.09062074
81cornea development in camera-type eye (GO:0061303)3.06337273
82negative regulation of mast cell activation (GO:0033004)3.05597528
83ketone body metabolic process (GO:1902224)3.05021521
84regulation of nuclear cell cycle DNA replication (GO:0033262)3.04505559
85ribosome assembly (GO:0042255)3.01994267
86positive regulation of prostaglandin secretion (GO:0032308)3.00719706
87regulation of cilium movement (GO:0003352)3.00572869
88molting cycle (GO:0042303)25.8866842
89hair cycle (GO:0042633)25.8866842
90keratinocyte proliferation (GO:0043616)2.97669133
91phosphatidylcholine acyl-chain remodeling (GO:0036151)2.97349941
92lung-associated mesenchyme development (GO:0060484)2.94124861
93intraciliary transport (GO:0042073)2.93940379
94protein K11-linked deubiquitination (GO:0035871)2.93912425
95mitotic metaphase plate congression (GO:0007080)2.92866260
96amine catabolic process (GO:0009310)2.92743897
97cellular biogenic amine catabolic process (GO:0042402)2.92743897
98anterograde synaptic vesicle transport (GO:0048490)2.91537372
99nonmotile primary cilium assembly (GO:0035058)2.91111416
100preassembly of GPI anchor in ER membrane (GO:0016254)2.91089459
101negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88307215
102establishment of protein localization to mitochondrial membrane (GO:0090151)2.88206103
103regulation of keratinocyte proliferation (GO:0010837)2.86488449
104cilium morphogenesis (GO:0060271)2.85614794
105indole-containing compound metabolic process (GO:0042430)2.82634683
106mannosylation (GO:0097502)2.82611234
107mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.82502218
108ventricular cardiac muscle cell action potential (GO:0086005)2.82433575
109regulation of hexokinase activity (GO:1903299)2.82136785
110regulation of glucokinase activity (GO:0033131)2.82136785
111protein neddylation (GO:0045116)2.81587410
112cilium organization (GO:0044782)2.79922725
113hair follicle development (GO:0001942)2.78962174
114ribosomal large subunit biogenesis (GO:0042273)2.78590383
115viral transcription (GO:0019083)2.77523396
116rhodopsin mediated signaling pathway (GO:0016056)2.77162357
117phosphatidylserine metabolic process (GO:0006658)2.75357394
118epithelium development (GO:0060429)2.74112810
119cilium assembly (GO:0042384)2.73642710
120positive regulation of meiotic cell cycle (GO:0051446)2.72769953
121tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71941407
122RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71941407
123translational termination (GO:0006415)2.71184071
124negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.69917360
125adenosine metabolic process (GO:0046085)2.68899100
126regulation of rhodopsin mediated signaling pathway (GO:0022400)2.68767719
127sulfation (GO:0051923)2.67312226
128protein polyglutamylation (GO:0018095)2.67247306
129cilium or flagellum-dependent cell motility (GO:0001539)2.66294151
130lymph vessel development (GO:0001945)2.65863645
131G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65316941
132maturation of SSU-rRNA (GO:0030490)2.64553139
133reflex (GO:0060004)2.63749089
134inositol phosphate catabolic process (GO:0071545)2.63504917
135negative regulation of transcription regulatory region DNA binding (GO:2000678)2.63261858
136atrioventricular valve morphogenesis (GO:0003181)2.62679959
137proline transport (GO:0015824)2.61315311
138L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60213941
139behavioral response to ethanol (GO:0048149)2.59296651
140DNA methylation involved in gamete generation (GO:0043046)2.59006388
141replication fork processing (GO:0031297)2.57270886
142recombinational repair (GO:0000725)2.56272017
143double-strand break repair via homologous recombination (GO:0000724)2.55616945
144ribosomal small subunit biogenesis (GO:0042274)2.55233299
145translational initiation (GO:0006413)2.54186055
146tooth mineralization (GO:0034505)2.53958334
147photoreceptor cell development (GO:0042461)2.53013711
148protein localization to cilium (GO:0061512)2.52206919
149adaptation of signaling pathway (GO:0023058)2.52144031
150dopamine transport (GO:0015872)2.51559621
151male meiosis I (GO:0007141)2.51437728
152gamma-aminobutyric acid transport (GO:0015812)2.49213710
153regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.49125774
154alanine transport (GO:0032328)2.47412276
155negative regulation of epidermal cell differentiation (GO:0045605)2.47119678
156alditol phosphate metabolic process (GO:0052646)2.46085897
157neuronal action potential (GO:0019228)2.45692302
158photoreceptor cell maintenance (GO:0045494)2.45606674
159GPI anchor metabolic process (GO:0006505)2.45446543
160protein K6-linked ubiquitination (GO:0085020)2.45364682
161negative regulation of epidermis development (GO:0045683)2.44753589
162nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.44357560
163negative regulation of DNA-dependent DNA replication (GO:2000104)2.43433159
164signal peptide processing (GO:0006465)2.41436114
165aromatic amino acid family catabolic process (GO:0009074)2.41311868
166positive regulation of fatty acid transport (GO:2000193)2.40109663
167spinal cord motor neuron differentiation (GO:0021522)2.39391078
168regulation of telomere maintenance (GO:0032204)2.39256731
169positive regulation of keratinocyte differentiation (GO:0045618)2.37959292
170proteasome assembly (GO:0043248)2.37520420
171mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.37119398
172pseudouridine synthesis (GO:0001522)2.36713273
173peptidyl-histidine modification (GO:0018202)2.35748550
174negative regulation of cell fate specification (GO:0009996)2.33560366
175benzene-containing compound metabolic process (GO:0042537)2.33407228
176exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.33048103
177regulation of ruffle assembly (GO:1900027)2.32695675
178positive regulation of Cdc42 GTPase activity (GO:0043089)2.28112719
179piRNA metabolic process (GO:0034587)2.25969170
180translational elongation (GO:0006414)2.24921128
181fatty acid elongation (GO:0030497)2.23599105
182metaphase plate congression (GO:0051310)2.23381971
183eyelid development in camera-type eye (GO:0061029)2.19559866
184formation of translation preinitiation complex (GO:0001731)2.18515046
185oocyte development (GO:0048599)2.15511645
186long-chain fatty acid biosynthetic process (GO:0042759)2.14859159
187nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.12022340
188regulation of Cdc42 GTPase activity (GO:0043088)2.09725260
189skin development (GO:0043588)2.09468355
190cellular protein complex disassembly (GO:0043624)2.08433147
191anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.07592727
192phosphatidylglycerol metabolic process (GO:0046471)2.07150899
193viral life cycle (GO:0019058)2.06359571
194SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.05135581
195negative regulation of protein localization to plasma membrane (GO:1903077)2.04639312
196ribonucleoprotein complex biogenesis (GO:0022613)2.04340486
197desmosome organization (GO:0002934)11.6801666
198keratinization (GO:0031424)11.5941264
199intermediate filament organization (GO:0045109)10.6277168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.83272459
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.96067491
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.04732131
4ZNF274_21170338_ChIP-Seq_K562_Hela3.86351775
5P63_26484246_Chip-Seq_KERATINOCYTES_Human3.44142431
6VDR_22108803_ChIP-Seq_LS180_Human3.27619426
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.97900877
8GBX2_23144817_ChIP-Seq_PC3_Human2.85416979
9IGF1R_20145208_ChIP-Seq_DFB_Human2.62172981
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.60524565
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56906801
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39280315
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31022568
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30910244
15EZH2_22144423_ChIP-Seq_EOC_Human2.30797983
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.16845287
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16159947
18EWS_26573619_Chip-Seq_HEK293_Human2.15848067
19FUS_26573619_Chip-Seq_HEK293_Human2.15147848
20ZNF263_19887448_ChIP-Seq_K562_Human2.11687436
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09537718
22BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.09516026
23P300_19829295_ChIP-Seq_ESCs_Human2.06679921
24TP63_17297297_ChIP-ChIP_HaCaT_Human14.5416354
25CTCF_20526341_ChIP-Seq_ESCs_Human1.99300521
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.99077034
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98067902
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96107915
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96001378
30ER_23166858_ChIP-Seq_MCF-7_Human1.91917189
31TAF15_26573619_Chip-Seq_HEK293_Human1.88664922
32SOX9_24532713_ChIP-Seq_HFSC_Mouse1.86816008
33KAP1_22055183_ChIP-Seq_ESCs_Mouse1.84786937
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.76574392
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73475526
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73312832
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.72344735
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.72344735
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.71731802
40ATF3_27146783_Chip-Seq_COLON_Human1.70067541
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67502790
42NANOG_20526341_ChIP-Seq_ESCs_Human1.65440940
43BCAT_22108803_ChIP-Seq_LS180_Human1.63307472
44NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.61638660
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.61585320
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58770496
47E2F1_20622854_ChIP-Seq_HELA_Human1.58759389
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.57943963
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.57851299
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57429178
51CBP_20019798_ChIP-Seq_JUKART_Human1.55652244
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55652244
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54546358
54P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.52621350
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.51564312
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51423592
57SMAD4_21799915_ChIP-Seq_A2780_Human1.49525808
58CSB_26484114_Chip-Seq_FIBROBLAST_Human1.49240186
59TP63_22573176_ChIP-Seq_HFKS_Human1.48691994
60ELK1_19687146_ChIP-ChIP_HELA_Human1.48436416
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48348111
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48109060
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.46900883
64TAF2_19829295_ChIP-Seq_ESCs_Human1.46877497
65TP53_22573176_ChIP-Seq_HFKS_Human1.46348596
66AR_25329375_ChIP-Seq_VCAP_Human1.45504783
67MYC_18940864_ChIP-ChIP_HL60_Human1.44916476
68STAT3_23295773_ChIP-Seq_U87_Human1.44815986
69BCOR_27268052_Chip-Seq_Bcells_Human1.44277317
70GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.43291052
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.41951597
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40030460
73SOX2_19829295_ChIP-Seq_ESCs_Human1.39928990
74NANOG_19829295_ChIP-Seq_ESCs_Human1.39928990
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38725415
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.38626160
77RACK7_27058665_Chip-Seq_MCF-7_Human1.38188794
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37788394
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37108076
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37108076
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.36732273
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35239790
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35145106
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35006291
85AR_21909140_ChIP-Seq_LNCAP_Human1.33197716
86TCF4_23295773_ChIP-Seq_U87_Human1.32930124
87TCF4_22108803_ChIP-Seq_LS180_Human1.32677726
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.31542198
89ERG_20517297_ChIP-Seq_VCAP_Human1.31000905
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29386397
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29206695
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27721154
93P53_21459846_ChIP-Seq_SAOS-2_Human1.26792165
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26326415
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25772949
96GATA3_24758297_ChIP-Seq_MCF-7_Human1.25577990
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25368715
98IRF1_19129219_ChIP-ChIP_H3396_Human1.25187037
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24623430
100GATA6_21074721_ChIP-Seq_CACO-2_Human1.23135951
101BCL6_27268052_Chip-Seq_Bcells_Human1.23104168
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22684418
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22614008
104FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20760525
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20610950
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20237932
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.18627554
108P53_22387025_ChIP-Seq_ESCs_Mouse1.18210189
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.18152818
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18121989
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18073573
112UBF1/2_26484160_Chip-Seq_HMECs_Human1.18011436
113VDR_23849224_ChIP-Seq_CD4+_Human1.17979539
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17741409
115REST_21632747_ChIP-Seq_MESCs_Mouse1.17045701
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16907632
117NCOR_22424771_ChIP-Seq_293T_Human1.16735361
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16371322
119PHF8_20622854_ChIP-Seq_HELA_Human1.16312959
120GATA4_25053715_ChIP-Seq_YYC3_Human1.15850443
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15680030
122RUNX2_22187159_ChIP-Seq_PCA_Human1.14913701
123AR_20517297_ChIP-Seq_VCAP_Human1.14689413
124BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13764972
125GATA3_21878914_ChIP-Seq_MCF-7_Human1.13713429
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.13305849
127P68_20966046_ChIP-Seq_HELA_Human1.11806467
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.11165393
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.10881971
130GATA3_21867929_ChIP-Seq_TH1_Mouse1.10751061
131CTCF_27219007_Chip-Seq_Bcells_Human1.10178996
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09948516
133RNF2_27304074_Chip-Seq_NSC_Mouse1.09879148
134PRDM14_20953172_ChIP-Seq_ESCs_Human1.09207833
135CEBPB_22108803_ChIP-Seq_LS180_Human1.08961444
136SMAD4_21741376_ChIP-Seq_EPCs_Human1.08357892
137ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08198905
138FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07413136
139HTT_18923047_ChIP-ChIP_STHdh_Human1.07388948
140ELK1_22589737_ChIP-Seq_MCF10A_Human1.06669108
141MYC_18555785_ChIP-Seq_MESCs_Mouse1.06146063
142MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.06106015
143E2F1_18555785_Chip-Seq_ESCs_Mouse1.05733604
144ETV1_20927104_ChIP-Seq_GIST48_Human1.05242264
145CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03742316
146SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02533143
147HOXB7_26014856_ChIP-Seq_BT474_Human1.02405889
148ETS1_20019798_ChIP-Seq_JURKAT_Human1.02378851
149SMC4_20622854_ChIP-Seq_HELA_Human1.02374453
150RAC3_21632823_ChIP-Seq_H3396_Human1.01602505
151CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01523231
152RUNX1_27514584_Chip-Seq_MCF-7_Human1.00683536
153EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00403229
154PHF8_20622853_ChIP-Seq_HELA_Human1.00389342
155SRF_21415370_ChIP-Seq_HL-1_Mouse0.99358206
156CDX2_22108803_ChIP-Seq_LS180_Human0.99146979
157SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98845239
158RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98783314
159FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95377426
160KLF5_25053715_ChIP-Seq_YYC3_Human0.94482416
161E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93732606
162ELF1_20517297_ChIP-Seq_JURKAT_Human0.93033324
163RBPJ_21746931_ChIP-Seq_IB4_Human0.92558824
164FOXH1_21741376_ChIP-Seq_ESCs_Human0.91869451
165KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87611165
166GATA6_25053715_ChIP-Seq_YYC3_Human0.87204304
167CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86858119
168TP53_20018659_ChIP-ChIP_R1E_Mouse0.86344566
169SA1_27219007_Chip-Seq_ERYTHROID_Human0.86144758
170GABP_17652178_ChIP-ChIP_JURKAT_Human0.86132409
171JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.85544585
172JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85265818
173STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83098563
174NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82938597
175TP63_23658742_ChIP-Seq_EP156T_Human0.81819533
176SOX2_21211035_ChIP-Seq_LN229_Human0.81583233
177SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79690849
178NANOG_18555785_ChIP-Seq_MESCs_Mouse0.79454983
179JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75970588
180LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.75547034
181SOX2_20726797_ChIP-Seq_SW620_Human0.75080811
182RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74242401
183SA1_27219007_Chip-Seq_Bcells_Human0.72913828
184AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72545663
185RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71221240
186SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.71102434
187EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.70489078
188MYC_19829295_ChIP-Seq_ESCs_Human0.70095388
189NANOG_18692474_ChIP-Seq_MEFs_Mouse0.69865809
190FOXA1_27270436_Chip-Seq_PROSTATE_Human0.69561887
191FOXA1_25329375_ChIP-Seq_VCAP_Human0.69561887
192JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.68344004
193HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.66076849
194SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.65297480
195STAT6_21828071_ChIP-Seq_BEAS2B_Human0.63834777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology6.95991505
2MP0002796_impaired_skin_barrier6.31977283
3MP0002098_abnormal_vibrissa_morphology5.86493101
4MP0010234_abnormal_vibrissa_follicle5.21112266
5MP0000647_abnormal_sebaceous_gland4.99337515
6MP0005275_abnormal_skin_tensile4.95494958
7MP0000383_abnormal_hair_follicle4.16083182
8MP0005501_abnormal_skin_physiology3.94569152
9MP0010678_abnormal_skin_adnexa3.80098475
10MP0000377_abnormal_hair_follicle3.61443208
11MP0000427_abnormal_hair_cycle3.21170245
12MP0003195_calcinosis3.16528386
13MP0004381_abnormal_hair_follicle3.07898352
14MP0000569_abnormal_digit_pigmentation3.03030921
15MP0002254_reproductive_system_inflammat2.99807981
16MP0003705_abnormal_hypodermis_morpholog2.98331185
17MP0001216_abnormal_epidermal_layer2.96265940
18MP0002102_abnormal_ear_morphology2.93092576
19MP0003136_yellow_coat_color2.77460644
20MP0003941_abnormal_skin_development2.77046764
21MP0008877_abnormal_DNA_methylation2.57042233
22MP0000372_irregular_coat_pigmentation2.44143943
23MP0003453_abnormal_keratinocyte_physiol2.41631639
24MP0005451_abnormal_body_composition2.41054137
25MP0005551_abnormal_eye_electrophysiolog2.36007982
26MP0006292_abnormal_olfactory_placode2.35789189
27MP0002060_abnormal_skin_morphology2.34211177
28MP0010771_integument_phenotype2.32810619
29MP0001968_abnormal_touch/_nociception2.30793171
30MP0009046_muscle_twitch2.26350786
31MP0004947_skin_inflammation2.15224690
32MP0002837_dystrophic_cardiac_calcinosis2.11471642
33MP0005645_abnormal_hypothalamus_physiol2.06647100
34MP0000367_abnormal_coat/_hair2.05705259
35MP0006072_abnormal_retinal_apoptosis1.99376290
36MP0002938_white_spotting1.98449679
37MP0002736_abnormal_nociception_after1.95116243
38MP0003880_abnormal_central_pattern1.93241916
39MP0005174_abnormal_tail_pigmentation1.91782806
40MP0000467_abnormal_esophagus_morphology1.89096540
41MP0002638_abnormal_pupillary_reflex1.87406983
42MP0005253_abnormal_eye_physiology1.85516276
43MP0004142_abnormal_muscle_tone1.85435718
44MP0005646_abnormal_pituitary_gland1.79473878
45MP0005084_abnormal_gallbladder_morpholo1.75008256
46MP0004043_abnormal_pH_regulation1.73488910
47MP0002234_abnormal_pharynx_morphology1.70477604
48MP0003787_abnormal_imprinting1.69930009
49MP0008872_abnormal_physiological_respon1.69522985
50MP0002876_abnormal_thyroid_physiology1.68115021
51MP0004133_heterotaxia1.67739153
52MP0003646_muscle_fatigue1.64480265
53MP0006276_abnormal_autonomic_nervous1.63746936
54MP0009745_abnormal_behavioral_response1.62891465
55MP0003718_maternal_effect1.61016084
56MP0002653_abnormal_ependyma_morphology1.57219378
57MP0000762_abnormal_tongue_morphology1.56618492
58MP0001243_abnormal_dermal_layer1.55497656
59MP0003566_abnormal_cell_adhesion1.52088029
60MP0001501_abnormal_sleep_pattern1.46077574
61MP0009931_abnormal_skin_appearance1.45991326
62MP0008875_abnormal_xenobiotic_pharmacok1.42639084
63MP0002272_abnormal_nervous_system1.40097444
64MP0003693_abnormal_embryo_hatching1.39594007
65MP0008058_abnormal_DNA_repair1.39396627
66MP0001986_abnormal_taste_sensitivity1.39155424
67MP0002735_abnormal_chemical_nociception1.38933677
68MP0001485_abnormal_pinna_reflex1.38618922
69MP0002909_abnormal_adrenal_gland1.36431827
70MP0003315_abnormal_perineum_morphology1.35826207
71MP0002163_abnormal_gland_morphology1.35482854
72MP0001346_abnormal_lacrimal_gland1.33565753
73MP0000631_abnormal_neuroendocrine_gland1.32990953
74MP0001529_abnormal_vocalization1.28355533
75MP0001905_abnormal_dopamine_level1.24023849
76MP0009053_abnormal_anal_canal1.23346248
77MP0001486_abnormal_startle_reflex1.20738075
78MP0001970_abnormal_pain_threshold1.19946265
79MP0000566_synostosis1.18362118
80MP0001191_abnormal_skin_condition1.17369412
81MP0005379_endocrine/exocrine_gland_phen1.16741997
82MP0004147_increased_porphyrin_level1.15453110
83MP0002572_abnormal_emotion/affect_behav1.15070752
84MP0005389_reproductive_system_phenotype1.14535785
85MP0002277_abnormal_respiratory_mucosa1.14114746
86MP0002557_abnormal_social/conspecific_i1.14043353
87MP0001984_abnormal_olfaction1.13431976
88MP0002064_seizures1.12686548
89MP0000015_abnormal_ear_pigmentation1.12151811
90MP0001764_abnormal_homeostasis1.12096445
91MP0010386_abnormal_urinary_bladder1.11999634
92MP0002928_abnormal_bile_duct1.11141053
93MP0002733_abnormal_thermal_nociception1.08094744
94MP0002090_abnormal_vision1.06869944
95MP0002067_abnormal_sensory_capabilities1.06797624
96MP0005171_absent_coat_pigmentation1.05022968
97MP0001919_abnormal_reproductive_system1.03707916
98MP0004742_abnormal_vestibular_system1.02156656
99MP0005195_abnormal_posterior_eye1.00993435
100MP0008789_abnormal_olfactory_epithelium0.97663772
101MP0004957_abnormal_blastocyst_morpholog0.96818549
102MP0004924_abnormal_behavior0.96390703
103MP0005386_behavior/neurological_phenoty0.96390703
104MP0000026_abnormal_inner_ear0.95203485
105MP0001324_abnormal_eye_pigmentation0.94197792
106MP0001661_extended_life_span0.93476185
107MP0003283_abnormal_digestive_organ0.93023159
108MP0000627_abnormal_mammary_gland0.92874031
109MP0002160_abnormal_reproductive_system0.91384214
110MP0004185_abnormal_adipocyte_glucose0.89129764
111MP0004264_abnormal_extraembryonic_tissu0.88618910
112MP0001963_abnormal_hearing_physiology0.86136613
113MP0005410_abnormal_fertilization0.85631728
114MP0003698_abnormal_male_reproductive0.85598209
115MP0002229_neurodegeneration0.84947177
116MP0000230_abnormal_systemic_arterial0.84077373
117MP0003252_abnormal_bile_duct0.83746062
118MP0000371_diluted_coat_color0.83534729
119MP0002210_abnormal_sex_determination0.82290419
120MP0002752_abnormal_somatic_nervous0.82271504
121MP0002822_catalepsy0.82130458
122MP0005332_abnormal_amino_acid0.81672510
123MP0001929_abnormal_gametogenesis0.81467883
124MP0002751_abnormal_autonomic_nervous0.81346687
125MP0008995_early_reproductive_senescence0.80718987
126MP0002734_abnormal_mechanical_nocicepti0.77562368
127MP0003111_abnormal_nucleus_morphology0.77483094
128MP0002693_abnormal_pancreas_physiology0.75528632
129MP0003121_genomic_imprinting0.75197118
130MP0004019_abnormal_vitamin_homeostasis0.72666066
131MP0001851_eye_inflammation0.72274352
132MP0005423_abnormal_somatic_nervous0.71925061
133MP0000653_abnormal_sex_gland0.71733041
134MP0002184_abnormal_innervation0.71324305
135MP0010352_gastrointestinal_tract_polyps0.70578191
136MP0002249_abnormal_larynx_morphology0.69936525
137MP0005083_abnormal_biliary_tract0.69888238
138MP0003755_abnormal_palate_morphology0.69876099
139MP0000465_gastrointestinal_hemorrhage0.69568366
140MP0002095_abnormal_skin_pigmentation0.67605356
141MP0005023_abnormal_wound_healing0.62063154
142MP0009840_abnormal_foam_cell0.61999392
143MP0001849_ear_inflammation0.61744628
144MP0002877_abnormal_melanocyte_morpholog0.60886390
145MP0005395_other_phenotype0.60291226
146MP0005367_renal/urinary_system_phenotyp0.59164520
147MP0000516_abnormal_urinary_system0.59164520
148MP0001340_abnormal_eyelid_morphology0.58870779
149MP0010030_abnormal_orbit_morphology0.57173039
150MP0002111_abnormal_tail_morphology0.57113022
151MP0003011_delayed_dark_adaptation0.54535116
152MP0008932_abnormal_embryonic_tissue0.53308274
153MP0005075_abnormal_melanosome_morpholog0.51048391
154MP0004885_abnormal_endolymph0.50492947
155MP0008260_abnormal_autophagy0.50314079
156MP0002177_abnormal_outer_ear0.48673524
157MP0002282_abnormal_trachea_morphology0.48306733
158MP0003329_amyloid_beta_deposits0.46546451
159MP0001542_abnormal_bone_strength0.45196119
160MP0001784_abnormal_fluid_regulation0.44945505
161MP0010094_abnormal_chromosome_stability0.43275948
162MP0003699_abnormal_female_reproductive0.42550594
163MP0003077_abnormal_cell_cycle0.41769329
164MP0003763_abnormal_thymus_physiology0.41444724
165MP0006054_spinal_hemorrhage0.36117261
166MP0003191_abnormal_cellular_cholesterol0.35431889
167MP0005409_darkened_coat_color0.35384793
168MP0001730_embryonic_growth_arrest0.34555405
169MP0005076_abnormal_cell_differentiation0.33358026
170MP0005508_abnormal_skeleton_morphology0.32858273
171MP0003786_premature_aging0.32824910
172MP0001119_abnormal_female_reproductive0.32751333
173MP0003936_abnormal_reproductive_system0.31786802
174MP0001756_abnormal_urination0.30123736
175MP0000432_abnormal_head_morphology0.29027074
176MP0003950_abnormal_plasma_membrane0.27371888
177MP0003937_abnormal_limbs/digits/tail_de0.26466590
178MP0002233_abnormal_nose_morphology0.26142114
179MP0000678_abnormal_parathyroid_gland0.25835364
180MP0000613_abnormal_salivary_gland0.25624073
181MP0003938_abnormal_ear_development0.25536607
182MP0009333_abnormal_splenocyte_physiolog0.25494126
183MP0009379_abnormal_foot_pigmentation0.25185299
184MP0000350_abnormal_cell_proliferation0.24976498
185MP0003935_abnormal_craniofacial_develop0.24743724
186MP0002697_abnormal_eye_size0.24620260
187MP0008007_abnormal_cellular_replicative0.24255026
188MP0000750_abnormal_muscle_regeneration0.22256726
189MP0005408_hypopigmentation0.21774939
190MP0002970_abnormal_white_adipose0.21404685
191MP0002009_preneoplasia0.21265654
192MP0003567_abnormal_fetal_cardiomyocyte0.20623960

Predicted human phenotypes

RankGene SetZ-score
1Woolly hair (HP:0002224)9.60636135
2Brittle hair (HP:0002299)8.53199925
3Pili torti (HP:0003777)8.04045940
4Abnormality of hair growth rate (HP:0011363)7.70331156
5Slow-growing hair (HP:0002217)7.70331156
6Abnormality of nail color (HP:0100643)7.13302428
7Nail dystrophy (HP:0008404)6.36755988
8Increased IgE level (HP:0003212)5.55676081
9Palmoplantar hyperkeratosis (HP:0000972)5.36618230
10Fragile nails (HP:0001808)5.32289475
11Palmar hyperkeratosis (HP:0010765)5.10849090
12Plantar hyperkeratosis (HP:0007556)4.93627261
13Abnormal hair laboratory examination (HP:0003328)4.89336773
14Onycholysis (HP:0001806)4.77524903
15Right ventricular cardiomyopathy (HP:0011663)4.60372407
16Alopecia of scalp (HP:0002293)4.56845980
17Erythema (HP:0010783)4.49234830
18Erythroderma (HP:0001019)4.38059739
19Sparse eyelashes (HP:0000653)4.29905603
20Thick nail (HP:0001805)4.24451299
21Pancreatic fibrosis (HP:0100732)4.22237425
22Congenital ichthyosiform erythroderma (HP:0007431)4.21658117
23True hermaphroditism (HP:0010459)4.15651799
24Pancreatic cysts (HP:0001737)4.12679595
25Oral leukoplakia (HP:0002745)4.04647106
26Abnormality of midbrain morphology (HP:0002418)4.00346903
27Molar tooth sign on MRI (HP:0002419)4.00346903
28Fine hair (HP:0002213)3.97508653
29Parakeratosis (HP:0001036)3.89934746
30Follicular hyperkeratosis (HP:0007502)3.89812579
31Natal tooth (HP:0000695)3.88595714
32Congenital stationary night blindness (HP:0007642)3.87501921
33Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.41820726
34Nephronophthisis (HP:0000090)3.37361066
35Congenital, generalized hypertrichosis (HP:0004540)3.35780459
36Abnormal blistering of the skin (HP:0008066)3.21213432
37Lip pit (HP:0100267)3.07445315
38Acute necrotizing encephalopathy (HP:0006965)3.01570493
39Medial flaring of the eyebrow (HP:0010747)2.97317382
40Abnormal drinking behavior (HP:0030082)2.97216991
41Polydipsia (HP:0001959)2.97216991
42Abolished electroretinogram (ERG) (HP:0000550)2.95963876
43Abnormality of the renal medulla (HP:0100957)2.91137321
44Milia (HP:0001056)2.83438574
45Advanced eruption of teeth (HP:0006288)2.82503272
46Chronic hepatic failure (HP:0100626)2.77860956
47Mitochondrial inheritance (HP:0001427)2.77304830
48Attenuation of retinal blood vessels (HP:0007843)2.77008704
49Ventricular fibrillation (HP:0001663)2.73421140
50Acute encephalopathy (HP:0006846)2.70670920
51Progressive macrocephaly (HP:0004481)2.69893590
52Hypothermia (HP:0002045)2.68259876
53Abnormal rod and cone electroretinograms (HP:0008323)2.66467252
54Hyperventilation (HP:0002883)2.64340916
55Curly hair (HP:0002212)2.62381625
563-Methylglutaconic aciduria (HP:0003535)2.58049220
57Sparse scalp hair (HP:0002209)2.56768342
58Tubular atrophy (HP:0000092)2.55807887
59Type II lissencephaly (HP:0007260)2.55068404
60Dry hair (HP:0011359)2.54662819
61Abnormality of the renal cortex (HP:0011035)2.53828370
62Increased CSF lactate (HP:0002490)2.53452453
63Abnormal mitochondria in muscle tissue (HP:0008316)2.51061148
64Cystic liver disease (HP:0006706)2.49574996
65Amelogenesis imperfecta (HP:0000705)2.47063588
66Polyuria (HP:0000103)2.46056479
67Palmoplantar keratoderma (HP:0000982)2.45454161
68Hypohidrosis (HP:0000966)2.40590527
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.39111248
70Absent/shortened dynein arms (HP:0200106)2.39111248
71Intestinal atresia (HP:0011100)2.37197830
72Hypomagnesemia (HP:0002917)2.35652143
73Ridged nail (HP:0001807)2.34313775
74Sclerocornea (HP:0000647)2.33955924
75Large for gestational age (HP:0001520)2.33295771
76Abnormality of the pons (HP:0007361)2.31409066
77Concave nail (HP:0001598)2.30923974
78Abnormality of secondary sexual hair (HP:0009888)2.29732141
79Abnormality of the axillary hair (HP:0100134)2.29732141
80Premature ovarian failure (HP:0008209)2.28315070
81Anencephaly (HP:0002323)2.26426358
82Hepatocellular necrosis (HP:0001404)2.26320597
83Corneal erosion (HP:0200020)2.26201338
84Gait imbalance (HP:0002141)2.25590593
85Lipid accumulation in hepatocytes (HP:0006561)2.24606002
86Aplasia/Hypoplasia of the tongue (HP:0010295)2.24104186
87Congenital primary aphakia (HP:0007707)2.22143977
88Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21121349
89Ventricular tachycardia (HP:0004756)2.18530257
90Aplasia/Hypoplasia of the fovea (HP:0008060)2.18265030
91Hypoplasia of the fovea (HP:0007750)2.18265030
92Inability to walk (HP:0002540)2.17887126
93Hypoplasia of the pons (HP:0012110)2.17854015
94Congenital hepatic fibrosis (HP:0002612)2.17264950
95Methylmalonic acidemia (HP:0002912)2.16511920
96Male pseudohermaphroditism (HP:0000037)2.16134196
97Abnormal respiratory epithelium morphology (HP:0012253)2.16008862
98Abnormal respiratory motile cilium morphology (HP:0005938)2.16008862
99Gaze-evoked nystagmus (HP:0000640)2.14319043
100Methylmalonic aciduria (HP:0012120)2.13977509
101Blepharitis (HP:0000498)2.12503068
102Abnormal ciliary motility (HP:0012262)2.11899038
103Hepatic necrosis (HP:0002605)2.11473860
104Neck muscle weakness (HP:0000467)2.11356453
105Conjunctival hamartoma (HP:0100780)2.08705596
106Pendular nystagmus (HP:0012043)2.08660720
107Increased hepatocellular lipid droplets (HP:0006565)2.07601310
108Decreased central vision (HP:0007663)2.06508025
109Febrile seizures (HP:0002373)2.05992433
110Progressive inability to walk (HP:0002505)2.04844461
111Bony spicule pigmentary retinopathy (HP:0007737)2.03800868
112Nephrogenic diabetes insipidus (HP:0009806)2.02662112
113Thyroid-stimulating hormone excess (HP:0002925)2.01829354
114Genital tract atresia (HP:0001827)2.01221504
115Amniotic constriction ring (HP:0009775)2.00885339
116Abnormality of placental membranes (HP:0011409)2.00885339
117Ectropion (HP:0000656)2.00479389
118Hypotrichosis (HP:0001006)12.0274515
119Pruritus (HP:0000989)1.99864659
120Hemiparesis (HP:0001269)1.99812095
121Furrowed tongue (HP:0000221)1.99142237
122Broad-based gait (HP:0002136)1.98592715
123Lissencephaly (HP:0001339)1.98551141
124Optic disc pallor (HP:0000543)1.98427434
125Postaxial foot polydactyly (HP:0001830)1.95045082
126Abnormality of the labia minora (HP:0012880)1.93281092
127Abnormality of macular pigmentation (HP:0008002)1.90354974
128Abnormality of the aortic arch (HP:0012303)1.89902599
129Abnormal respiratory motile cilium physiology (HP:0012261)1.89756772
130Optic nerve hypoplasia (HP:0000609)1.89743969
131Abnormality of the fovea (HP:0000493)1.88931957
132Ketoacidosis (HP:0001993)1.87957497
133Abnormal urine output (HP:0012590)1.87593163
134Aplasia cutis congenita (HP:0001057)1.86206492
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.85966784
136Vaginal atresia (HP:0000148)1.84845811
137Aplasia/Hypoplasia of the uvula (HP:0010293)1.84502184
138Anonychia (HP:0001798)1.84144096
139Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83794547
140Gastrointestinal atresia (HP:0002589)1.83520410
141Cerebral edema (HP:0002181)1.80527965
142Hyperglycinuria (HP:0003108)1.79534406
143Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79459503
144Abnormal biliary tract physiology (HP:0012439)1.78408207
145Bile duct proliferation (HP:0001408)1.78408207
146Tetany (HP:0001281)1.77756250
147Premature rupture of membranes (HP:0001788)1.77722703
148Increased serum lactate (HP:0002151)1.77365485
149Dialeptic seizures (HP:0011146)1.76907188
150Fatigable weakness (HP:0003473)1.76849360
151Abnormality of the neuromuscular junction (HP:0003398)1.76849360
152Acanthosis nigricans (HP:0000956)1.76764608
153Rough bone trabeculation (HP:0100670)1.76486486
154Trismus (HP:0000211)1.75600190
155Double outlet right ventricle (HP:0001719)1.75422023
156Congenital malformation of the right heart (HP:0011723)1.75422023
157Absent eyelashes (HP:0000561)1.75283794
158Postaxial hand polydactyly (HP:0001162)1.75272038
159Abnormality of the distal phalanges of the toes (HP:0010182)1.75262105
160Breast hypoplasia (HP:0003187)1.74897570
161Unilateral renal agenesis (HP:0000122)1.74541829
162Increased corneal curvature (HP:0100692)1.74102914
163Keratoconus (HP:0000563)1.74102914
164Occipital encephalocele (HP:0002085)1.73792291
165Astigmatism (HP:0000483)1.73525153
166Decreased circulating renin level (HP:0003351)1.72553558
167Cerebellar dysplasia (HP:0007033)1.72200605
168Renal Fanconi syndrome (HP:0001994)1.72018808
169Corneal dystrophy (HP:0001131)1.71577843
170Male infertility (HP:0003251)1.70905136
171Abnormality of the frontal sinuses (HP:0002687)1.68201920
172Aplasia/hypoplasia of the uterus (HP:0008684)1.67497546
173Popliteal pterygium (HP:0009756)1.65463317
174Distal lower limb muscle weakness (HP:0009053)1.62880578
175Abnormality of dental color (HP:0011073)1.62048940
176Abnormality of molar morphology (HP:0011070)1.57301699
177Abnormality of molar (HP:0011077)1.57301699
178Abnormalities of placenta or umbilical cord (HP:0001194)1.55583829
179Abnormality of the dental root (HP:0006486)1.55392954
180Taurodontia (HP:0000679)1.55392954
181Abnormality of permanent molar morphology (HP:0011071)1.55392954
182Secondary amenorrhea (HP:0000869)1.55336972
183Cerebral hypomyelination (HP:0006808)1.54099495
184Intention tremor (HP:0002080)1.53782721
185Gangrene (HP:0100758)1.52647426
186Areflexia of lower limbs (HP:0002522)1.52531820
187Hypergammaglobulinemia (HP:0010702)1.50664874
188Abnormality of the dental pulp (HP:0006479)1.48270208
189Abnormality of the fingernails (HP:0001231)1.44978973
190Laryngomalacia (HP:0001601)1.44924385
191Carious teeth (HP:0000670)1.43961486
192Difficulty walking (HP:0002355)1.43294235
193Ureteral duplication (HP:0000073)1.41954744
194Pterygium (HP:0001059)1.41573923
195Delusions (HP:0000746)1.41003036
196Hypoplasia of the uterus (HP:0000013)1.39921407
197Abnormal trabecular bone morphology (HP:0100671)1.39630174
198Neonatal death (HP:0003811)1.39202745
199Hypoplastic labia majora (HP:0000059)1.38870826

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.26603632
2FRK5.23910809
3MAPKAPK33.67895970
4MAP3K33.26811722
5BUB13.16617707
6ADRBK23.06644151
7LATS12.98124946
8MAP3K62.93670796
9WNK32.87523192
10MAP4K22.54933381
11FER2.47742724
12EPHB22.40739746
13TAOK12.35308353
14TTK2.34672129
15RPS6KB22.26092311
16LATS22.12212905
17WEE12.06178721
18ERN12.05877873
19STK38L1.97095904
20TAOK31.94751733
21MST1R1.94604362
22TNIK1.92948572
23PLK41.92237028
24PIM21.89035908
25TLK11.87887428
26STK241.86888904
27MKNK21.85375197
28PNCK1.82795602
29CASK1.77402727
30MST41.75155585
31WNK41.71544132
32MAPK131.65065291
33EEF2K1.63818250
34SRPK11.61612328
35NME11.61156300
36MAP3K21.60554213
37INSRR1.59864724
38NME21.59480033
39CAMKK21.57228165
40TRIM281.46232769
41VRK11.45636890
42NTRK31.45203301
43VRK21.44609249
44STK391.43590555
45OXSR11.41669778
46BRAF1.36630358
47MAP3K91.35045662
48TSSK61.34838871
49PRKCI1.34148354
50TAF11.32536560
51MAP3K111.29743707
52NEK21.27232115
53PAK31.22462399
54RPS6KA41.22003475
55MAP3K41.21211516
56AKT31.16684037
57CAMK1D1.15866718
58MAPK151.15528980
59PLK21.13066773
60ARAF1.12029861
61CAMK1G1.10742898
62LRRK21.10734704
63PRKCG1.09848365
64STK31.09786362
65IRAK31.08769587
66AURKB1.08476864
67MAP3K81.07759300
68STK101.02580295
69MKNK10.99993657
70EIF2AK10.97901930
71MELK0.97783176
72ADRBK10.96904805
73PLK10.96807560
74PRKCE0.93507187
75BLK0.92986226
76BCKDK0.91943842
77PINK10.90084240
78BCR0.88665621
79PIK3CG0.88656142
80FGFR40.88238132
81ZAK0.87107485
82STK380.86160182
83EPHA40.85708662
84TXK0.85359429
85NLK0.85203900
86MAP2K70.84659090
87TGFBR10.84335431
88MAP3K50.83622724
89AURKA0.83589316
90ERBB30.83373234
91DYRK30.81989625
92DYRK20.81840640
93DAPK20.80436972
94CSNK1G20.79274141
95TEC0.78959437
96CSNK1G30.77885541
97NUAK10.76365008
98BRSK20.74453783
99ACVR1B0.73292202
100PTK2B0.72061897
101MARK10.71590431
102ERBB40.71280078
103MAPKAPK20.69904938
104TRPM70.67857417
105CHEK20.67104848
106ABL20.66953910
107CAMK10.66404121
108PDK20.66155489
109PHKG10.66057234
110PHKG20.66057234
111PLK30.65636982
112FGFR20.65081351
113EPHA30.64615425
114IKBKB0.62218969
115NEK10.61471874
116MAP2K60.61351487
117MARK30.59584771
118TIE10.59497184
119PKN10.59097009
120PDK40.58964785
121PDK30.58964785
122EIF2AK30.58864412
123MOS0.56653520
124GRK10.54306106
125CDK30.53935978
126CSNK1A1L0.53857594
127CSNK1E0.53732124
128DYRK1B0.51363633
129CCNB10.50759010
130MAP3K10.50604445
131CDC70.50459498
132PRKCQ0.49619703
133TTN0.49048079
134KSR20.47824066
135CDK60.46830725
136TNK20.46348031
137TYK20.46154728
138CAMK2A0.45815130
139PRKACA0.44695932
140TESK10.44249388
141EIF2AK20.43359264
142PAK10.43254269
143MAPKAPK50.41664744
144KIT0.41205781
145ILK0.41041487
146STK160.40310592
147RPS6KA50.38353407
148MUSK0.38326076
149IRAK10.38093431
150NTRK20.37616134
151RAF10.37167615
152TRIB30.36393380
153DYRK1A0.36367082
154RPS6KA10.36363307
155FLT30.35440631
156CSNK1D0.34624952
157PRKCA0.34279121
158ERBB20.33126195
159STK110.32791538
160GRK50.32749416
161ALK0.32681149
162BRSK10.32296715
163MAP2K30.32152863
164ABL10.31116261
165MAP2K10.28135977
166CSNK1A10.27050049
167FGFR30.25750751
168PAK40.25477206
169MAP2K20.25274784
170BMPR1B0.25270330
171CSNK1G10.23288871

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005914.71851027
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.51990219
3Proteasome_Homo sapiens_hsa030504.26787729
4Ribosome_Homo sapiens_hsa030103.82710051
5Vitamin B6 metabolism_Homo sapiens_hsa007503.31611915
6RNA polymerase_Homo sapiens_hsa030203.26663771
7Oxidative phosphorylation_Homo sapiens_hsa001902.86059846
8Arachidonic acid metabolism_Homo sapiens_hsa005902.84183299
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68517114
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54570241
11Ether lipid metabolism_Homo sapiens_hsa005652.45725968
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45032668
13Protein export_Homo sapiens_hsa030602.33300985
14Butanoate metabolism_Homo sapiens_hsa006502.30180087
15p53 signaling pathway_Homo sapiens_hsa041152.24622025
16Parkinsons disease_Homo sapiens_hsa050122.18126068
17Glycerophospholipid metabolism_Homo sapiens_hsa005642.11540366
18RNA transport_Homo sapiens_hsa030132.06401249
19Selenocompound metabolism_Homo sapiens_hsa004502.05177856
20Maturity onset diabetes of the young_Homo sapiens_hsa049502.04433237
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.03005573
22Sphingolipid metabolism_Homo sapiens_hsa006001.99859960
23Fanconi anemia pathway_Homo sapiens_hsa034601.93757431
24Fatty acid elongation_Homo sapiens_hsa000621.80863748
25Propanoate metabolism_Homo sapiens_hsa006401.80565530
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78581896
27Nitrogen metabolism_Homo sapiens_hsa009101.78572779
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76957889
29Tryptophan metabolism_Homo sapiens_hsa003801.76371284
30Caffeine metabolism_Homo sapiens_hsa002321.75189561
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70382922
32Phenylalanine metabolism_Homo sapiens_hsa003601.68322349
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.68298187
34Huntingtons disease_Homo sapiens_hsa050161.63132268
35Fat digestion and absorption_Homo sapiens_hsa049751.61372052
36Cell cycle_Homo sapiens_hsa041101.58601816
37Nicotine addiction_Homo sapiens_hsa050331.57833311
38Regulation of autophagy_Homo sapiens_hsa041401.54591051
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.47643262
40Basal cell carcinoma_Homo sapiens_hsa052171.44485313
41Histidine metabolism_Homo sapiens_hsa003401.42924687
42Alzheimers disease_Homo sapiens_hsa050101.38443629
43Basal transcription factors_Homo sapiens_hsa030221.34401776
44Pyrimidine metabolism_Homo sapiens_hsa002401.31468390
45Hippo signaling pathway_Homo sapiens_hsa043901.27728188
46One carbon pool by folate_Homo sapiens_hsa006701.27141431
47Peroxisome_Homo sapiens_hsa041461.21162332
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17869776
49Olfactory transduction_Homo sapiens_hsa047401.15685984
50Morphine addiction_Homo sapiens_hsa050321.14732770
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13112238
52Taste transduction_Homo sapiens_hsa047421.11690666
53Cardiac muscle contraction_Homo sapiens_hsa042601.11596130
54Hedgehog signaling pathway_Homo sapiens_hsa043401.09233703
55Folate biosynthesis_Homo sapiens_hsa007901.08198075
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08059735
57Spliceosome_Homo sapiens_hsa030401.06243498
58TGF-beta signaling pathway_Homo sapiens_hsa043501.05941300
59Oocyte meiosis_Homo sapiens_hsa041141.05828043
60Mineral absorption_Homo sapiens_hsa049781.05033605
61VEGF signaling pathway_Homo sapiens_hsa043701.02945257
62Tight junction_Homo sapiens_hsa045301.01619814
63Retinol metabolism_Homo sapiens_hsa008301.00269077
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98489268
65Vitamin digestion and absorption_Homo sapiens_hsa049770.95280527
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95262000
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94280048
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93420007
69Pentose phosphate pathway_Homo sapiens_hsa000300.92970537
70Epstein-Barr virus infection_Homo sapiens_hsa051690.91749026
71beta-Alanine metabolism_Homo sapiens_hsa004100.91428662
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.90167071
73Steroid biosynthesis_Homo sapiens_hsa001000.89031528
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87872621
75Mismatch repair_Homo sapiens_hsa034300.87701712
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87682370
77Insulin secretion_Homo sapiens_hsa049110.87507380
78Serotonergic synapse_Homo sapiens_hsa047260.83816446
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83062625
80GABAergic synapse_Homo sapiens_hsa047270.80448004
81Non-homologous end-joining_Homo sapiens_hsa034500.80142327
82MicroRNAs in cancer_Homo sapiens_hsa052060.79378198
83Tyrosine metabolism_Homo sapiens_hsa003500.77812101
84Metabolic pathways_Homo sapiens_hsa011000.76730164
85Thyroid cancer_Homo sapiens_hsa052160.76419905
86ABC transporters_Homo sapiens_hsa020100.75855983
87Adherens junction_Homo sapiens_hsa045200.74142812
88Bladder cancer_Homo sapiens_hsa052190.73465369
89Circadian entrainment_Homo sapiens_hsa047130.72410263
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70858801
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70010691
92Glutathione metabolism_Homo sapiens_hsa004800.69618547
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69059359
94Sulfur metabolism_Homo sapiens_hsa009200.68970779
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68629999
96Glutamatergic synapse_Homo sapiens_hsa047240.67605766
97Salivary secretion_Homo sapiens_hsa049700.65070492
98Ovarian steroidogenesis_Homo sapiens_hsa049130.64921520
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.63978306
100GnRH signaling pathway_Homo sapiens_hsa049120.63817751
101Antigen processing and presentation_Homo sapiens_hsa046120.62740629
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62175962
103RNA degradation_Homo sapiens_hsa030180.59208994
104Proteoglycans in cancer_Homo sapiens_hsa052050.59075894
105ECM-receptor interaction_Homo sapiens_hsa045120.57818215
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57513391
107Primary immunodeficiency_Homo sapiens_hsa053400.57368595
108Purine metabolism_Homo sapiens_hsa002300.55986020
109Chemical carcinogenesis_Homo sapiens_hsa052040.54774210
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.54553636
111Renal cell carcinoma_Homo sapiens_hsa052110.53532672
112Melanogenesis_Homo sapiens_hsa049160.53495879
113DNA replication_Homo sapiens_hsa030300.53314385
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53109452
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52868250
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.52551630
117Phototransduction_Homo sapiens_hsa047440.51956563
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49274023
119Ras signaling pathway_Homo sapiens_hsa040140.48709121
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48239965
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47785410
122Fatty acid metabolism_Homo sapiens_hsa012120.47702300
123Circadian rhythm_Homo sapiens_hsa047100.47624665
124Sulfur relay system_Homo sapiens_hsa041220.47362375
125Dorso-ventral axis formation_Homo sapiens_hsa043200.46042687
126Calcium signaling pathway_Homo sapiens_hsa040200.45580725
127Homologous recombination_Homo sapiens_hsa034400.45456714
128Base excision repair_Homo sapiens_hsa034100.44999005
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43066288
130Axon guidance_Homo sapiens_hsa043600.41446467
131HTLV-I infection_Homo sapiens_hsa051660.40559603
132Nucleotide excision repair_Homo sapiens_hsa034200.39035315
133Fatty acid degradation_Homo sapiens_hsa000710.38753379
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38224836
135Rheumatoid arthritis_Homo sapiens_hsa053230.36940759
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36939225
137FoxO signaling pathway_Homo sapiens_hsa040680.36609286
138Dopaminergic synapse_Homo sapiens_hsa047280.36416129
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34590244
140Type I diabetes mellitus_Homo sapiens_hsa049400.33609517
141Staphylococcus aureus infection_Homo sapiens_hsa051500.33316932
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.33117555
143Wnt signaling pathway_Homo sapiens_hsa043100.32806937
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31560258
145Acute myeloid leukemia_Homo sapiens_hsa052210.31257355
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.30631217
147Glycerolipid metabolism_Homo sapiens_hsa005610.30207715
148Asthma_Homo sapiens_hsa053100.29203129
149Apoptosis_Homo sapiens_hsa042100.27740746
150Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27109535
151Small cell lung cancer_Homo sapiens_hsa052220.26653043
152Endocytosis_Homo sapiens_hsa041440.25931010
153Lysosome_Homo sapiens_hsa041420.25472452
154Drug metabolism - other enzymes_Homo sapiens_hsa009830.24346249
155Collecting duct acid secretion_Homo sapiens_hsa049660.21813225
156Melanoma_Homo sapiens_hsa052180.21489201
157Leukocyte transendothelial migration_Homo sapiens_hsa046700.21323216
158Notch signaling pathway_Homo sapiens_hsa043300.20589253
159Pathways in cancer_Homo sapiens_hsa052000.20212585
160Endometrial cancer_Homo sapiens_hsa052130.19799125

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