PIN4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)8.61136836
2viral transcription (GO:0019083)7.50102059
3translational termination (GO:0006415)7.15482658
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.49262082
5ribosomal small subunit assembly (GO:0000028)6.46310274
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.26169813
7translational elongation (GO:0006414)6.22560317
8ATP synthesis coupled proton transport (GO:0015986)6.21333332
9energy coupled proton transport, down electrochemical gradient (GO:0015985)6.21333332
10cotranslational protein targeting to membrane (GO:0006613)6.15485187
11protein targeting to ER (GO:0045047)6.09258248
12chaperone-mediated protein transport (GO:0072321)6.08924820
13maturation of SSU-rRNA (GO:0030490)5.90259368
14establishment of protein localization to endoplasmic reticulum (GO:0072599)5.84328048
15establishment of protein localization to mitochondrial membrane (GO:0090151)5.83662987
16protein localization to endoplasmic reticulum (GO:0070972)5.70046625
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.64261873
18viral life cycle (GO:0019058)5.51970248
19cellular protein complex disassembly (GO:0043624)5.43383479
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.27707026
21respiratory electron transport chain (GO:0022904)5.19427961
22electron transport chain (GO:0022900)5.11082767
23protein complex biogenesis (GO:0070271)5.03839616
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.00927325
25mitochondrial respiratory chain complex I assembly (GO:0032981)5.00927325
26NADH dehydrogenase complex assembly (GO:0010257)5.00927325
27translational initiation (GO:0006413)4.96215344
28protein neddylation (GO:0045116)4.87422672
29mitochondrial respiratory chain complex assembly (GO:0033108)4.65074785
30protein complex disassembly (GO:0043241)4.63438780
31translation (GO:0006412)4.60904490
32ribosomal large subunit biogenesis (GO:0042273)4.54187550
33regulation of mitochondrial translation (GO:0070129)4.50196196
34pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.46593440
35macromolecular complex disassembly (GO:0032984)4.38025133
36ncRNA 3-end processing (GO:0043628)4.32321530
37deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.03488486
38cellular component biogenesis (GO:0044085)4.02630400
39protein targeting to membrane (GO:0006612)4.01813925
40proteasome assembly (GO:0043248)4.01420868
41ribonucleoprotein complex biogenesis (GO:0022613)3.94849083
42pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.77815913
43pyrimidine nucleotide catabolic process (GO:0006244)3.75323444
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.75120344
45termination of RNA polymerase III transcription (GO:0006386)3.75120344
46nuclear-transcribed mRNA catabolic process (GO:0000956)3.72894823
47protein targeting to mitochondrion (GO:0006626)3.72083374
48ATP biosynthetic process (GO:0006754)3.69166393
49purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.63296549
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.59883472
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.59883472
52purine nucleoside triphosphate biosynthetic process (GO:0009145)3.57848549
53mRNA catabolic process (GO:0006402)3.53004310
54rRNA processing (GO:0006364)3.52016551
55establishment of protein localization to mitochondrion (GO:0072655)3.46280475
56behavioral response to nicotine (GO:0035095)3.45532798
57GTP biosynthetic process (GO:0006183)3.44708712
58cytochrome complex assembly (GO:0017004)3.43032269
59DNA deamination (GO:0045006)3.41129872
60rRNA metabolic process (GO:0016072)3.36877621
61hydrogen ion transmembrane transport (GO:1902600)3.36606355
62pseudouridine synthesis (GO:0001522)3.34411870
63RNA catabolic process (GO:0006401)3.30427108
64DNA damage response, detection of DNA damage (GO:0042769)3.30383044
65protein localization to mitochondrion (GO:0070585)3.29921415
66peptidyl-histidine modification (GO:0018202)3.23525584
67RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.21323738
68ribonucleoside triphosphate biosynthetic process (GO:0009201)3.19489676
69respiratory chain complex IV assembly (GO:0008535)3.18348277
70inner mitochondrial membrane organization (GO:0007007)3.12385546
71protein-cofactor linkage (GO:0018065)3.03493139
72proton transport (GO:0015992)3.00923708
73protein targeting (GO:0006605)2.96111503
74mitochondrial transport (GO:0006839)2.93197376
75hydrogen transport (GO:0006818)2.91689816
76UTP biosynthetic process (GO:0006228)2.91441242
77nucleoside triphosphate biosynthetic process (GO:0009142)2.90798631
78water-soluble vitamin biosynthetic process (GO:0042364)2.88394070
79pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.88078311
80chromatin remodeling at centromere (GO:0031055)2.81028679
81intracellular protein transmembrane import (GO:0044743)2.78668425
82pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.78063073
83establishment of protein localization to membrane (GO:0090150)2.71485963
84UTP metabolic process (GO:0046051)2.66917676
85establishment of protein localization to organelle (GO:0072594)2.66729130
86deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.64884065
87guanosine-containing compound biosynthetic process (GO:1901070)2.64309738
88protein deneddylation (GO:0000338)2.61748346
89tRNA processing (GO:0008033)2.61108586
90ncRNA processing (GO:0034470)2.60379658
91spliceosomal snRNP assembly (GO:0000387)2.56506415
92spliceosomal complex assembly (GO:0000245)2.54499913
93histone exchange (GO:0043486)2.54366121
94neurofilament cytoskeleton organization (GO:0060052)2.53946302
95positive regulation of protein homooligomerization (GO:0032464)2.53587185
96CENP-A containing nucleosome assembly (GO:0034080)2.53369730
97regulation of cellular amino acid metabolic process (GO:0006521)2.51155075
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47860877
99CTP biosynthetic process (GO:0006241)2.47698076
100CTP metabolic process (GO:0046036)2.47698076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.44466796
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.96276413
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.56588390
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.50271435
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.38844436
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.31463350
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.23841615
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.19324695
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.02069973
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96899844
11EZH2_22144423_ChIP-Seq_EOC_Human2.71134476
12VDR_22108803_ChIP-Seq_LS180_Human2.54115791
13VDR_23849224_ChIP-Seq_CD4+_Human2.27351044
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25341387
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25060054
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15942057
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13768736
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.08747392
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06803385
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02994229
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99324042
22XRN2_22483619_ChIP-Seq_HELA_Human1.98480487
23GABP_19822575_ChIP-Seq_HepG2_Human1.93591231
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92622047
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.92068407
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86726084
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.81386036
28TTF2_22483619_ChIP-Seq_HELA_Human1.80380399
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.79796133
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74431215
31ELK1_19687146_ChIP-ChIP_HELA_Human1.74316703
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70018814
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69339061
34ZNF274_21170338_ChIP-Seq_K562_Hela1.65421437
35MYC_18940864_ChIP-ChIP_HL60_Human1.64217128
36FOXP3_21729870_ChIP-Seq_TREG_Human1.62554303
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.60702606
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60621056
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59532225
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59122184
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57922986
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55188521
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.50286048
44SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48326344
45FUS_26573619_Chip-Seq_HEK293_Human1.45604054
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43756310
47RNF2_27304074_Chip-Seq_NSC_Mouse1.43442332
48DCP1A_22483619_ChIP-Seq_HELA_Human1.41318531
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38379026
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.38116727
51IGF1R_20145208_ChIP-Seq_DFB_Human1.35438503
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.28620070
53SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27382138
54SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26685126
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26400358
56EWS_26573619_Chip-Seq_HEK293_Human1.22915394
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21670430
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21217502
59ZNF263_19887448_ChIP-Seq_K562_Human1.17570829
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16971151
61E2F7_22180533_ChIP-Seq_HELA_Human1.16248075
62CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14123223
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14053160
64SOX2_16153702_ChIP-ChIP_HESCs_Human1.09365394
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08888566
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07682014
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06753617
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05562627
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05520598
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04722592
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01695745
72FOXP1_21924763_ChIP-Seq_HESCs_Human1.01003150
73TP63_19390658_ChIP-ChIP_HaCaT_Human0.98549227
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98456862
75KDM5A_27292631_Chip-Seq_BREAST_Human0.96681194
76TP53_22573176_ChIP-Seq_HFKS_Human0.95649081
77EZH2_27294783_Chip-Seq_ESCs_Mouse0.95606200
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94075972
79ELK1_22589737_ChIP-Seq_MCF10A_Human0.93774319
80NCOR_22424771_ChIP-Seq_293T_Human0.93543890
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93341532
82JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93190506
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92479796
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91751177
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91643344
86TAF2_19829295_ChIP-Seq_ESCs_Human0.91130705
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89184878
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88998288
89P53_21459846_ChIP-Seq_SAOS-2_Human0.86364030
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86141926
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85772139
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84534129
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84383817
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83652499
95TET1_21451524_ChIP-Seq_MESCs_Mouse0.83454306
96IRF1_19129219_ChIP-ChIP_H3396_Human0.83095178
97ERG_20517297_ChIP-Seq_VCAP_Human0.82753111
98CIITA_25753668_ChIP-Seq_RAJI_Human0.81419454
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80751272
100NANOG_20526341_ChIP-Seq_ESCs_Human0.80121717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.25119873
2MP0003123_paternal_imprinting3.89882770
3MP0002163_abnormal_gland_morphology3.31572835
4MP0000372_irregular_coat_pigmentation2.75387791
5MP0006292_abnormal_olfactory_placode2.51085875
6MP0008789_abnormal_olfactory_epithelium2.41183482
7MP0003121_genomic_imprinting2.38607362
8MP0005084_abnormal_gallbladder_morpholo2.36876454
9MP0003806_abnormal_nucleotide_metabolis2.20038320
10MP0005394_taste/olfaction_phenotype2.16697954
11MP0005499_abnormal_olfactory_system2.16697954
12MP0006276_abnormal_autonomic_nervous2.09559139
13MP0003787_abnormal_imprinting2.08624453
14MP0002277_abnormal_respiratory_mucosa2.08481346
15MP0003880_abnormal_central_pattern2.05181014
16MP0003136_yellow_coat_color1.94787507
17MP0003646_muscle_fatigue1.87349234
18MP0001968_abnormal_touch/_nociception1.86026268
19MP0001529_abnormal_vocalization1.84500112
20MP0005423_abnormal_somatic_nervous1.76778583
21MP0000049_abnormal_middle_ear1.72450458
22MP0002736_abnormal_nociception_after1.67376725
23MP0004145_abnormal_muscle_electrophysio1.61960746
24MP0002095_abnormal_skin_pigmentation1.59005080
25MP0005379_endocrine/exocrine_gland_phen1.58525997
26MP0004142_abnormal_muscle_tone1.52760977
27MP0001188_hyperpigmentation1.52207833
28MP0002160_abnormal_reproductive_system1.51225806
29MP0003122_maternal_imprinting1.50033968
30MP0002638_abnormal_pupillary_reflex1.44911232
31MP0009046_muscle_twitch1.41998533
32MP0005646_abnormal_pituitary_gland1.41420561
33MP0002837_dystrophic_cardiac_calcinosis1.40605275
34MP0003938_abnormal_ear_development1.38925591
35MP0003937_abnormal_limbs/digits/tail_de1.37959463
36MP0002102_abnormal_ear_morphology1.31981492
37MP0005551_abnormal_eye_electrophysiolog1.31714343
38MP0002938_white_spotting1.31381186
39MP0001905_abnormal_dopamine_level1.29882870
40MP0009745_abnormal_behavioral_response1.28897219
41MP0001486_abnormal_startle_reflex1.27586404
42MP0003186_abnormal_redox_activity1.26202697
43MP0006072_abnormal_retinal_apoptosis1.25208652
44MP0003315_abnormal_perineum_morphology1.23643514
45MP0001485_abnormal_pinna_reflex1.21482757
46MP0002876_abnormal_thyroid_physiology1.20326227
47MP0006036_abnormal_mitochondrial_physio1.19658628
48MP0002272_abnormal_nervous_system1.17287270
49MP0003567_abnormal_fetal_cardiomyocyte1.15395065
50MP0008877_abnormal_DNA_methylation1.12668085
51MP0003786_premature_aging1.10291340
52MP0005367_renal/urinary_system_phenotyp1.09961322
53MP0000516_abnormal_urinary_system1.09961322
54MP0004885_abnormal_endolymph1.05964844
55MP0000778_abnormal_nervous_system1.05724525
56MP0008995_early_reproductive_senescence1.04919087
57MP0005389_reproductive_system_phenotype1.03769584
58MP0000955_abnormal_spinal_cord1.03764217
59MP0000678_abnormal_parathyroid_gland1.03621022
60MP0002928_abnormal_bile_duct1.03096585
61MP0001984_abnormal_olfaction1.01703153
62MP0008875_abnormal_xenobiotic_pharmacok1.01360664
63MP0009250_abnormal_appendicular_skeleto1.00883049
64MP0005187_abnormal_penis_morphology0.98664463
65MP0002733_abnormal_thermal_nociception0.96998778
66MP0001970_abnormal_pain_threshold0.96987789
67MP0002138_abnormal_hepatobiliary_system0.95581622
68MP0002184_abnormal_innervation0.95467896
69MP0008058_abnormal_DNA_repair0.95264036
70MP0000750_abnormal_muscle_regeneration0.95199972
71MP0003693_abnormal_embryo_hatching0.94847468
72MP0002249_abnormal_larynx_morphology0.92665131
73MP0000631_abnormal_neuroendocrine_gland0.92146149
74MP0004742_abnormal_vestibular_system0.91659121
75MP0005174_abnormal_tail_pigmentation0.90619125
76MP0002557_abnormal_social/conspecific_i0.90216364
77MP0005195_abnormal_posterior_eye0.90059543
78MP0001764_abnormal_homeostasis0.90005055
79MP0001270_distended_abdomen0.89625020
80MP0002090_abnormal_vision0.89243274
81MP0002752_abnormal_somatic_nervous0.89241550
82MP0000647_abnormal_sebaceous_gland0.88896493
83MP0003119_abnormal_digestive_system0.88162304
84MP0005645_abnormal_hypothalamus_physiol0.87548163
85MP0003635_abnormal_synaptic_transmissio0.86111213
86MP0004858_abnormal_nervous_system0.85660126
87MP0001502_abnormal_circadian_rhythm0.84605453
88MP0002210_abnormal_sex_determination0.83140585
89MP0000026_abnormal_inner_ear0.82585578
90MP0008872_abnormal_physiological_respon0.82409489
91MP0001293_anophthalmia0.79254644
92MP0002233_abnormal_nose_morphology0.79056161
93MP0005408_hypopigmentation0.75402763
94MP0000534_abnormal_ureter_morphology0.73579898
95MP0002572_abnormal_emotion/affect_behav0.73209448
96MP0002067_abnormal_sensory_capabilities0.72721718
97MP0003755_abnormal_palate_morphology0.70988170
98MP0002177_abnormal_outer_ear0.69974042
99MP0001963_abnormal_hearing_physiology0.66880893
100MP0002735_abnormal_chemical_nociception0.66593011

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.51792649
2Abnormal mitochondria in muscle tissue (HP:0008316)4.85981945
3Mitochondrial inheritance (HP:0001427)4.80309236
4Acute encephalopathy (HP:0006846)4.52078804
5Progressive macrocephaly (HP:0004481)4.41877590
6Increased CSF lactate (HP:0002490)4.34948533
7Renal Fanconi syndrome (HP:0001994)3.87568678
8Abnormality of cells of the erythroid lineage (HP:0012130)3.83221845
9Hepatocellular necrosis (HP:0001404)3.78552685
10Stenosis of the external auditory canal (HP:0000402)3.70803746
11Reticulocytopenia (HP:0001896)3.68752184
12Increased hepatocellular lipid droplets (HP:0006565)3.61547892
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.53129221
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.53129221
15Cerebral edema (HP:0002181)3.42094446
16Abnormal number of erythroid precursors (HP:0012131)3.42041991
17Congenital stationary night blindness (HP:0007642)3.39430662
18Symphalangism affecting the phalanges of the hand (HP:0009773)3.37890506
19Hepatic necrosis (HP:0002605)3.34252156
203-Methylglutaconic aciduria (HP:0003535)3.34061992
21Split foot (HP:0001839)3.31990388
22Macrocytic anemia (HP:0001972)3.30166269
23Oligodactyly (hands) (HP:0001180)3.12190089
24Lipid accumulation in hepatocytes (HP:0006561)3.06983778
25Increased intramyocellular lipid droplets (HP:0012240)2.92345154
26Myokymia (HP:0002411)2.89239579
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.88796654
28Concave nail (HP:0001598)2.85499804
29Pancreatic cysts (HP:0001737)2.65016885
30Exertional dyspnea (HP:0002875)2.55579804
31Increased serum lactate (HP:0002151)2.54735047
32Lactic acidosis (HP:0003128)2.52914425
33Abnormality of renal resorption (HP:0011038)2.52583511
34Pallor (HP:0000980)2.52129297
35Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.51559766
36Oligodactyly (HP:0012165)2.47963755
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47239696
38Abnormality of alanine metabolism (HP:0010916)2.47239696
39Hyperalaninemia (HP:0003348)2.47239696
40Optic disc pallor (HP:0000543)2.41738229
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37933641
42Generalized aminoaciduria (HP:0002909)2.37222025
43Pancreatic fibrosis (HP:0100732)2.36622716
44Hyperthyroidism (HP:0000836)2.36122907
45Molar tooth sign on MRI (HP:0002419)2.33629256
46Abnormality of midbrain morphology (HP:0002418)2.33629256
47Respiratory difficulties (HP:0002880)2.33487579
48Leukodystrophy (HP:0002415)2.33299004
49Abnormality of the phalanges of the 5th finger (HP:0004213)2.33144915
50Pendular nystagmus (HP:0012043)2.29162204
51Glycosuria (HP:0003076)2.28798781
52Abnormality of urine glucose concentration (HP:0011016)2.28798781
53Horseshoe kidney (HP:0000085)2.28560506
54Abnormality of the labia minora (HP:0012880)2.27139892
55Exercise intolerance (HP:0003546)2.26236072
56Septo-optic dysplasia (HP:0100842)2.23814247
57Increased muscle lipid content (HP:0009058)2.21534166
58Diastasis recti (HP:0001540)2.20346543
59Respiratory failure (HP:0002878)2.19358745
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13743034
61Abnormal rod and cone electroretinograms (HP:0008323)2.13451789
62Aplasia/Hypoplasia of the patella (HP:0006498)2.12700298
63X-linked dominant inheritance (HP:0001423)2.12455126
64Hyperphosphaturia (HP:0003109)2.04431254
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04243443
66Hydroureter (HP:0000072)1.98843892
67Rib fusion (HP:0000902)1.98424503
68Cerebral hypomyelination (HP:0006808)1.93909161
69Lethargy (HP:0001254)1.92858303
70Fibular aplasia (HP:0002990)1.91976771
71Patellar aplasia (HP:0006443)1.91430945
72Depressed nasal ridge (HP:0000457)1.91013781
73Abolished electroretinogram (ERG) (HP:0000550)1.89894957
74Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87775094
75Congenital, generalized hypertrichosis (HP:0004540)1.84938811
76Hyperglycinuria (HP:0003108)1.82308015
77Anophthalmia (HP:0000528)1.81506303
78Humeroradial synostosis (HP:0003041)1.81215905
79Synostosis involving the elbow (HP:0003938)1.81215905
80Abnormal urine phosphate concentration (HP:0012599)1.78204551
81Sclerocornea (HP:0000647)1.78042036
82True hermaphroditism (HP:0010459)1.74808069
83Cleft eyelid (HP:0000625)1.73017100
84Abnormality of macular pigmentation (HP:0008002)1.70846699
85Absent thumb (HP:0009777)1.70258749
86Partial duplication of thumb phalanx (HP:0009944)1.69964568
87Aplasia/hypoplasia of the uterus (HP:0008684)1.66772005
88Polydipsia (HP:0001959)1.64678632
89Abnormal drinking behavior (HP:0030082)1.64678632
90Nephronophthisis (HP:0000090)1.63317950
91Progressive microcephaly (HP:0000253)1.62211339
92Limb dystonia (HP:0002451)1.60748976
93Absent septum pellucidum (HP:0001331)1.60412575
94Hypoplasia of the radius (HP:0002984)1.60327550
95Optic nerve coloboma (HP:0000588)1.57507559
96Anencephaly (HP:0002323)1.56970761
97CNS demyelination (HP:0007305)1.56899104
98Status epilepticus (HP:0002133)1.56337979
99Abnormal number of incisors (HP:0011064)1.54740805
100Patent foramen ovale (HP:0001655)1.54058656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.05773897
2PDK22.72934086
3BCKDK2.36751716
4ZAK2.34917849
5WNK42.29378246
6STK162.27606813
7CASK2.20616352
8BUB12.13400850
9TLK12.11861936
10LIMK12.07516726
11PLK42.06173411
12ADRBK22.05379741
13MAP4K22.05198971
14CDK191.98009633
15CAMKK21.76618709
16GRK11.74009489
17EPHA21.69651655
18CDC71.67873556
19BCR1.67575110
20BMPR1B1.67207990
21MAP2K71.53933178
22TRIM281.52469096
23WNK31.50210206
24PIM21.44946258
25DYRK21.42567460
26NTRK21.39317557
27PINK11.38929461
28NME11.33036119
29ABL21.29321859
30ILK1.28436040
31CCNB11.27350711
32MARK11.19611908
33MAP3K41.18960099
34MINK11.10506813
35VRK21.09271387
36CAMK1D1.06467785
37PRKCG1.04839741
38MAPK131.04164768
39VRK11.00637210
40CHEK21.00068178
41GRK70.99482462
42INSRR0.97386484
43CAMK10.96723813
44AURKB0.94854370
45ARAF0.94132822
46CSNK2A20.92375094
47PRKD30.91172933
48OBSCN0.89531381
49TXK0.89312625
50SRPK10.87254355
51RPS6KA50.86118069
52DAPK10.84240621
53KDR0.81679878
54AURKA0.81621175
55FRK0.81092933
56CSNK1A10.80633185
57EPHA40.79584001
58PKN10.79228405
59ADRBK10.77737750
60DAPK30.74921531
61PLK10.74217077
62CSNK2A10.72143833
63LRRK20.71947575
64PAK30.71472575
65DYRK1B0.71087226
66NUAK10.70702136
67PRKACA0.69887367
68LATS20.68075705
69CSNK1E0.67364098
70MKNK20.67041113
71ATR0.66817547
72OXSR10.65545691
73PRKCE0.65000074
74BRAF0.63214057
75PIK3CA0.61527818
76DYRK1A0.58739084
77STK390.57381227
78PIM10.56383604
79PAK10.53578035
80NTRK30.53082272
81PHKG10.52787964
82PHKG20.52787964
83WEE10.51688206
84EIF2AK10.51506802
85CAMK2G0.46687678
86CDK11A0.46207380
87BRSK10.46185642
88PLK20.46025102
89CAMK2A0.44672077
90TEC0.42847023
91PIK3CG0.42771137
92TIE10.41487821
93PRKG10.41061656
94PRKCA0.40748867
95PRKCQ0.40339529
96CAMK1G0.40186367
97PRKCD0.40157416
98CSNK1G20.38857564
99CAMK40.38558073
100STK30.37868997

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.79364108
2Oxidative phosphorylation_Homo sapiens_hsa001905.24993006
3Parkinsons disease_Homo sapiens_hsa050124.57349447
4Huntingtons disease_Homo sapiens_hsa050163.33722503
5Proteasome_Homo sapiens_hsa030503.19772816
6RNA polymerase_Homo sapiens_hsa030203.15404285
7Alzheimers disease_Homo sapiens_hsa050103.14534230
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.77530632
9Cardiac muscle contraction_Homo sapiens_hsa042602.69952874
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.19238047
11Protein export_Homo sapiens_hsa030602.02416864
12Pyrimidine metabolism_Homo sapiens_hsa002401.98656741
13DNA replication_Homo sapiens_hsa030301.87878158
14Homologous recombination_Homo sapiens_hsa034401.85030520
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61732385
16Sulfur relay system_Homo sapiens_hsa041221.54471672
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50828175
18One carbon pool by folate_Homo sapiens_hsa006701.50431896
19Spliceosome_Homo sapiens_hsa030401.47785611
20Mismatch repair_Homo sapiens_hsa034301.38858428
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26690637
22RNA transport_Homo sapiens_hsa030131.15855859
23Fanconi anemia pathway_Homo sapiens_hsa034601.14133637
24Collecting duct acid secretion_Homo sapiens_hsa049661.09058090
25Purine metabolism_Homo sapiens_hsa002301.08184156
26Linoleic acid metabolism_Homo sapiens_hsa005911.08122292
27Asthma_Homo sapiens_hsa053101.04246223
28Phototransduction_Homo sapiens_hsa047441.03153057
29Nicotine addiction_Homo sapiens_hsa050331.02185900
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99059817
31Vitamin B6 metabolism_Homo sapiens_hsa007500.98507024
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95977632
33Folate biosynthesis_Homo sapiens_hsa007900.91774864
34Basal transcription factors_Homo sapiens_hsa030220.85829193
35RNA degradation_Homo sapiens_hsa030180.83281636
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83252813
37Nitrogen metabolism_Homo sapiens_hsa009100.83170678
38Base excision repair_Homo sapiens_hsa034100.81725597
39Metabolic pathways_Homo sapiens_hsa011000.79901983
40Nucleotide excision repair_Homo sapiens_hsa034200.77985277
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71906648
42Caffeine metabolism_Homo sapiens_hsa002320.64447613
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61851623
44Ether lipid metabolism_Homo sapiens_hsa005650.61491542
45Pyruvate metabolism_Homo sapiens_hsa006200.60045885
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.58000044
47Steroid biosynthesis_Homo sapiens_hsa001000.57960298
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.56994623
49Synaptic vesicle cycle_Homo sapiens_hsa047210.56304383
50Olfactory transduction_Homo sapiens_hsa047400.55933752
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55137872
52Arachidonic acid metabolism_Homo sapiens_hsa005900.54336923
53p53 signaling pathway_Homo sapiens_hsa041150.51071731
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.50563678
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50507496
56Glutathione metabolism_Homo sapiens_hsa004800.50465443
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50206571
58Morphine addiction_Homo sapiens_hsa050320.49925453
59Fat digestion and absorption_Homo sapiens_hsa049750.48225583
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46458852
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45484359
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45465698
63Regulation of autophagy_Homo sapiens_hsa041400.43760873
64Autoimmune thyroid disease_Homo sapiens_hsa053200.43686432
65Butanoate metabolism_Homo sapiens_hsa006500.42451749
66Systemic lupus erythematosus_Homo sapiens_hsa053220.42367061
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40001500
68Taste transduction_Homo sapiens_hsa047420.39665738
69GABAergic synapse_Homo sapiens_hsa047270.39318238
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.39259857
71Graft-versus-host disease_Homo sapiens_hsa053320.39005801
72Chemical carcinogenesis_Homo sapiens_hsa052040.38895105
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.35387643
74Arginine and proline metabolism_Homo sapiens_hsa003300.34359645
75Retinol metabolism_Homo sapiens_hsa008300.34296211
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34061688
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33838623
78Allograft rejection_Homo sapiens_hsa053300.33505950
79Rheumatoid arthritis_Homo sapiens_hsa053230.32944575
80Peroxisome_Homo sapiens_hsa041460.32742900
81Serotonergic synapse_Homo sapiens_hsa047260.31122813
82Sulfur metabolism_Homo sapiens_hsa009200.28529776
83Cell cycle_Homo sapiens_hsa041100.28356953
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26387077
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26043472
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.25638365
87Type I diabetes mellitus_Homo sapiens_hsa049400.24706166
88Alcoholism_Homo sapiens_hsa050340.22843466
89Hedgehog signaling pathway_Homo sapiens_hsa043400.22191855
90Primary immunodeficiency_Homo sapiens_hsa053400.21582963
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21190166
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.20317153
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.17702900
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17337654
95Epstein-Barr virus infection_Homo sapiens_hsa051690.16738954
96Melanoma_Homo sapiens_hsa052180.14913392
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.14302411
98Dopaminergic synapse_Homo sapiens_hsa047280.13170752
99Wnt signaling pathway_Homo sapiens_hsa043100.12787587
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12719737

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »