PIN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.45148784
2ATP synthesis coupled proton transport (GO:0015986)8.06688032
3energy coupled proton transport, down electrochemical gradient (GO:0015985)8.06688032
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.20526442
5ribosomal small subunit biogenesis (GO:0042274)6.72939452
6respiratory electron transport chain (GO:0022904)6.29747631
7electron transport chain (GO:0022900)6.13268306
8viral transcription (GO:0019083)5.76355972
9protein neddylation (GO:0045116)5.73377052
10axon ensheathment in central nervous system (GO:0032291)5.72410921
11central nervous system myelination (GO:0022010)5.72410921
12translational termination (GO:0006415)5.59837335
13chaperone-mediated protein transport (GO:0072321)5.32021638
14cotranslational protein targeting to membrane (GO:0006613)5.28443358
15protein targeting to ER (GO:0045047)5.18315886
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.18165799
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.95939743
18protein localization to endoplasmic reticulum (GO:0070972)4.95147424
19ribosomal small subunit assembly (GO:0000028)4.83171759
20proteasome assembly (GO:0043248)4.71242501
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.68800567
22NADH dehydrogenase complex assembly (GO:0010257)4.68800567
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.68800567
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.65421215
25protein complex biogenesis (GO:0070271)4.59124101
26translational elongation (GO:0006414)4.50266116
27cellular protein complex disassembly (GO:0043624)4.45334553
28viral life cycle (GO:0019058)4.42200380
29ribosomal large subunit biogenesis (GO:0042273)4.34681071
30GTP biosynthetic process (GO:0006183)4.33831007
31transcription elongation from RNA polymerase III promoter (GO:0006385)4.31098078
32termination of RNA polymerase III transcription (GO:0006386)4.31098078
33maturation of SSU-rRNA (GO:0030490)4.21080621
34mitochondrial respiratory chain complex assembly (GO:0033108)4.16423408
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.01744237
36translational initiation (GO:0006413)3.98339866
37fatty acid elongation (GO:0030497)3.96836662
38purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.95618832
39translation (GO:0006412)3.94813754
40hydrogen ion transmembrane transport (GO:1902600)3.90106609
41purine nucleoside triphosphate biosynthetic process (GO:0009145)3.87277564
42ATP biosynthetic process (GO:0006754)3.84701067
43establishment of integrated proviral latency (GO:0075713)3.81922641
44regulation of mitochondrial translation (GO:0070129)3.75084260
45UTP biosynthetic process (GO:0006228)3.64424634
46cullin deneddylation (GO:0010388)3.63896152
47protein targeting to mitochondrion (GO:0006626)3.62956090
48protein complex disassembly (GO:0043241)3.61862251
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.60915900
50GPI anchor biosynthetic process (GO:0006506)3.60893121
51DNA damage response, detection of DNA damage (GO:0042769)3.55711466
52long-chain fatty acid biosynthetic process (GO:0042759)3.54504447
53establishment of protein localization to mitochondrion (GO:0072655)3.54346229
54proton transport (GO:0015992)3.53991272
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53214588
56RNA capping (GO:0036260)3.51354608
577-methylguanosine RNA capping (GO:0009452)3.51354608
58establishment of viral latency (GO:0019043)3.50539152
597-methylguanosine mRNA capping (GO:0006370)3.50281508
60spliceosomal snRNP assembly (GO:0000387)3.48537660
61protein targeting to membrane (GO:0006612)3.47484709
62macromolecular complex disassembly (GO:0032984)3.45240613
63protein deneddylation (GO:0000338)3.44520369
64ribonucleoside triphosphate biosynthetic process (GO:0009201)3.44467895
65hydrogen transport (GO:0006818)3.44216140
66chromatin remodeling at centromere (GO:0031055)3.42954099
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.40241739
68RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.40241739
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.39810713
70pseudouridine synthesis (GO:0001522)3.38017663
71preassembly of GPI anchor in ER membrane (GO:0016254)3.37922830
72regulation of cellular amino acid metabolic process (GO:0006521)3.37717625
73respiratory chain complex IV assembly (GO:0008535)3.36335639
74sequestering of actin monomers (GO:0042989)3.36068434
75water-soluble vitamin biosynthetic process (GO:0042364)3.35092896
76cellular component biogenesis (GO:0044085)3.31257356
77CENP-A containing nucleosome assembly (GO:0034080)3.30368421
78protein localization to mitochondrion (GO:0070585)3.28003721
79rRNA modification (GO:0000154)3.27838350
80protein-cofactor linkage (GO:0018065)3.27722828
81guanosine-containing compound biosynthetic process (GO:1901070)3.24342887
82ribonucleoprotein complex biogenesis (GO:0022613)3.20514053
83DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.20345989
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.19917694
85negative regulation of ligase activity (GO:0051352)3.19917694
86peptidyl-histidine modification (GO:0018202)3.19855462
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.18908639
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18443938
89intracellular protein transmembrane import (GO:0044743)3.17506177
90GPI anchor metabolic process (GO:0006505)3.15989161
91nuclear-transcribed mRNA catabolic process (GO:0000956)3.15322472
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14189862
93pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.13946946
94UTP metabolic process (GO:0046051)3.13715766
95* rRNA processing (GO:0006364)3.13320000
96inner mitochondrial membrane organization (GO:0007007)3.12957769
97intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12076823
98signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12076823
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09505480
100L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.09026831
101signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08690455
102signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08690455
103signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08690455
104mannosylation (GO:0097502)3.08000249
105* rRNA metabolic process (GO:0016072)3.01836945
106signal transduction involved in DNA damage checkpoint (GO:0072422)3.00830401
107signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00830401
108antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.00199114
109mRNA catabolic process (GO:0006402)2.98171962
110signal transduction involved in cell cycle checkpoint (GO:0072395)2.97250338
111transcription elongation from RNA polymerase I promoter (GO:0006362)2.96260145
112nucleoside triphosphate biosynthetic process (GO:0009142)2.94962119
113CTP biosynthetic process (GO:0006241)2.92035461
114CTP metabolic process (GO:0046036)2.92035461
115positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91323077
116cytochrome complex assembly (GO:0017004)2.90320471
117mitochondrial transport (GO:0006839)2.90193899
118purine nucleoside monophosphate biosynthetic process (GO:0009127)2.89636897
119purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.89636897
120substantia nigra development (GO:0021762)2.89124085
121regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88206164
122isoprenoid biosynthetic process (GO:0008299)2.87211806
123oxidative phosphorylation (GO:0006119)2.84829269
124regulation of cellular amine metabolic process (GO:0033238)2.83665265
125cholesterol biosynthetic process (GO:0006695)2.83534515
126spliceosomal complex assembly (GO:0000245)2.81684930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.68221664
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.73171977
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.47112610
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.20938888
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.81133007
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75445943
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.50958360
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.42971857
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42598825
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.18706579
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.16678554
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.14298762
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81353680
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.72379707
15VDR_22108803_ChIP-Seq_LS180_Human2.43718258
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.40686642
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.37443203
18ELK1_19687146_ChIP-ChIP_HELA_Human2.20338985
19VDR_23849224_ChIP-Seq_CD4+_Human2.15100819
20IRF1_19129219_ChIP-ChIP_H3396_Human2.14249613
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08910060
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04589464
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.00245931
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97335991
25DCP1A_22483619_ChIP-Seq_HELA_Human1.97220083
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92443868
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84217199
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80830092
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79113556
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76692872
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75842982
32ELK1_22589737_ChIP-Seq_MCF10A_Human1.74800769
33TAF15_26573619_Chip-Seq_HEK293_Human1.72815781
34ZNF274_21170338_ChIP-Seq_K562_Hela1.72072989
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67710759
36FUS_26573619_Chip-Seq_HEK293_Human1.67693156
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.64453635
38TTF2_22483619_ChIP-Seq_HELA_Human1.64415582
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64164123
40E2F7_22180533_ChIP-Seq_HELA_Human1.63618098
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62307444
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.57562924
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53472824
44XRN2_22483619_ChIP-Seq_HELA_Human1.49427224
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49252961
46* FOXP3_21729870_ChIP-Seq_TREG_Human1.47877115
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44250048
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43132384
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34168289
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33788070
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32020155
52MYC_18940864_ChIP-ChIP_HL60_Human1.31790434
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26289572
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22566550
55* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20756387
56ER_23166858_ChIP-Seq_MCF-7_Human1.20061510
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17669468
58EZH2_22144423_ChIP-Seq_EOC_Human1.12283613
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11803520
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.10173000
61SOX17_20123909_ChIP-Seq_XEN_Mouse1.08187269
62IGF1R_20145208_ChIP-Seq_DFB_Human1.07185405
63* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05024120
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04488502
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04348174
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.04005426
67EWS_26573619_Chip-Seq_HEK293_Human1.02738741
68GABP_19822575_ChIP-Seq_HepG2_Human1.02518820
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01762672
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01545780
71GBX2_23144817_ChIP-Seq_PC3_Human1.00781249
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00443245
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99909782
74KDM5A_27292631_Chip-Seq_BREAST_Human0.99527369
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99149532
76CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98876861
77TP53_22573176_ChIP-Seq_HFKS_Human0.98686472
78MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97852594
79E2F1_21310950_ChIP-Seq_MCF-7_Human0.97560425
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97171356
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96935156
82CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96279500
83NANOG_16153702_ChIP-ChIP_HESCs_Human0.96145256
84FLI1_27457419_Chip-Seq_LIVER_Mouse0.95354924
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95216595
86P300_19829295_ChIP-Seq_ESCs_Human0.92718034
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92670481
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92437592
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91590906
90CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91292407
91* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91057184
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90306731
93E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90189008
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87850500
95NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85748782
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85546280
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85489465
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85063370
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85016127
100HTT_18923047_ChIP-ChIP_STHdh_Human0.84724344
101EZH2_27304074_Chip-Seq_ESCs_Mouse0.84369272
102* SOX2_16153702_ChIP-ChIP_HESCs_Human0.83159319
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82864071
104ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82210870
105RNF2_27304074_Chip-Seq_NSC_Mouse0.81800646
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.79198861
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.78051342
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.77607261
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77366869
110CTCF_18555785_ChIP-Seq_MESCs_Mouse0.77363038
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77058881
112AR_20517297_ChIP-Seq_VCAP_Human0.76197653
113TAL1_26923725_Chip-Seq_HPCs_Mouse0.75865817
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74741266
115FOXA1_25329375_ChIP-Seq_VCAP_Human0.73682098
116FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73682098
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72971133
118SUZ12_18555785_Chip-Seq_ESCs_Mouse0.72607875
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72562763
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.71880990
121PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.69899548
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.69405915
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.68796941
124ELF5_23300383_ChIP-Seq_T47D_Human0.68645152
125STAT1_20625510_ChIP-Seq_HELA_Human0.68574645
126JARID2_20064375_ChIP-Seq_MESCs_Mouse0.68024211
127P300_18555785_Chip-Seq_ESCs_Mouse0.67951501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.67747663
2MP0001529_abnormal_vocalization4.51259150
3MP0003880_abnormal_central_pattern4.41017209
4MP0003136_yellow_coat_color3.49868121
5MP0001905_abnormal_dopamine_level3.37698859
6MP0000920_abnormal_myelination2.63675990
7MP0006276_abnormal_autonomic_nervous2.32037918
8MP0004142_abnormal_muscle_tone2.24665959
9MP0005409_darkened_coat_color2.22577177
10MP0002638_abnormal_pupillary_reflex2.18269625
11MP0005171_absent_coat_pigmentation2.14659700
12MP0005423_abnormal_somatic_nervous2.14191722
13MP0003693_abnormal_embryo_hatching2.14145050
14MP0003950_abnormal_plasma_membrane2.12147542
15MP0000372_irregular_coat_pigmentation2.00392231
16MP0002163_abnormal_gland_morphology1.89747983
17MP0004742_abnormal_vestibular_system1.87186884
18MP0010094_abnormal_chromosome_stability1.84736275
19MP0002272_abnormal_nervous_system1.83395995
20MP0002938_white_spotting1.82589972
21MP0005084_abnormal_gallbladder_morpholo1.81551219
22MP0003186_abnormal_redox_activity1.78383262
23MP0001986_abnormal_taste_sensitivity1.74114939
24MP0003718_maternal_effect1.72948051
25MP0001293_anophthalmia1.70222406
26MP0002277_abnormal_respiratory_mucosa1.65664159
27MP0001440_abnormal_grooming_behavior1.65517996
28MP0003123_paternal_imprinting1.64994491
29MP0001485_abnormal_pinna_reflex1.64911482
30MP0005646_abnormal_pituitary_gland1.63528649
31MP0002736_abnormal_nociception_after1.61336688
32MP0004381_abnormal_hair_follicle1.61234530
33MP0006292_abnormal_olfactory_placode1.60128154
34MP0010030_abnormal_orbit_morphology1.59415885
35MP0003121_genomic_imprinting1.58865408
36MP0003011_delayed_dark_adaptation1.58744166
37MP0002064_seizures1.58694841
38MP0001486_abnormal_startle_reflex1.57592064
39MP0000049_abnormal_middle_ear1.57080148
40MP0002160_abnormal_reproductive_system1.57038170
41MP0005379_endocrine/exocrine_gland_phen1.53293761
42MP0006036_abnormal_mitochondrial_physio1.52322344
43MP0002234_abnormal_pharynx_morphology1.48453212
44MP0001968_abnormal_touch/_nociception1.48185760
45MP0005645_abnormal_hypothalamus_physiol1.45419778
46MP0003806_abnormal_nucleotide_metabolis1.43839783
47MP0001727_abnormal_embryo_implantation1.43804116
48MP0005408_hypopigmentation1.42803779
49MP0009745_abnormal_behavioral_response1.40108777
50MP0000631_abnormal_neuroendocrine_gland1.39021143
51MP0006035_abnormal_mitochondrial_morpho1.38884969
52MP0004147_increased_porphyrin_level1.38876399
53MP0002102_abnormal_ear_morphology1.37211075
54MP0003077_abnormal_cell_cycle1.37090748
55MP0002734_abnormal_mechanical_nocicepti1.35779444
56MP0003111_abnormal_nucleus_morphology1.34643378
57MP0004270_analgesia1.33966585
58MP0000566_synostosis1.32600052
59MP0008877_abnormal_DNA_methylation1.31792142
60MP0005499_abnormal_olfactory_system1.29776926
61MP0005394_taste/olfaction_phenotype1.29776926
62MP0001188_hyperpigmentation1.28955245
63MP0002148_abnormal_hypersensitivity_rea1.24845747
64MP0009046_muscle_twitch1.24637871
65MP0001970_abnormal_pain_threshold1.23781664
66MP0002572_abnormal_emotion/affect_behav1.23463946
67MP0008995_early_reproductive_senescence1.21803630
68MP0003567_abnormal_fetal_cardiomyocyte1.21753173
69MP0001764_abnormal_homeostasis1.18757828
70MP0005389_reproductive_system_phenotype1.18685875
71MP0000778_abnormal_nervous_system1.17853699
72MP0001963_abnormal_hearing_physiology1.17366309
73MP0008260_abnormal_autophagy1.16883022
74MP0005410_abnormal_fertilization1.16134267
75MP0003787_abnormal_imprinting1.16070576
76MP0003937_abnormal_limbs/digits/tail_de1.15068953
77MP0005551_abnormal_eye_electrophysiolog1.14802951
78MP0010386_abnormal_urinary_bladder1.14284785
79MP0008872_abnormal_physiological_respon1.13430100
80MP0005187_abnormal_penis_morphology1.12688669
81MP0003938_abnormal_ear_development1.11265608
82MP0002822_catalepsy1.10479018
83MP0008007_abnormal_cellular_replicative1.10209594
84MP0006082_CNS_inflammation1.09993417
85MP0002735_abnormal_chemical_nociception1.09185284
86MP0000026_abnormal_inner_ear1.07609710
87MP0003122_maternal_imprinting1.06656451
88MP0002229_neurodegeneration1.05518090
89MP0008932_abnormal_embryonic_tissue1.05035201
90MP0002210_abnormal_sex_determination1.04343576
91MP0002132_abnormal_respiratory_system1.03901841
92MP0004043_abnormal_pH_regulation1.01753884
93MP0008057_abnormal_DNA_replication0.99759930
94MP0006072_abnormal_retinal_apoptosis0.99450296
95MP0009697_abnormal_copulation0.99393505
96MP0002067_abnormal_sensory_capabilities0.98525315
97MP0003119_abnormal_digestive_system0.98217661
98MP0002752_abnormal_somatic_nervous0.97788363
99MP0002233_abnormal_nose_morphology0.95108360
100MP0003690_abnormal_glial_cell0.94652363
101MP0002295_abnormal_pulmonary_circulatio0.93961503
102MP0000516_abnormal_urinary_system0.93208539
103MP0005367_renal/urinary_system_phenotyp0.93208539
104MP0003786_premature_aging0.92437212
105MP0001346_abnormal_lacrimal_gland0.92223825
106MP0001919_abnormal_reproductive_system0.92109855
107MP0001286_abnormal_eye_development0.91474389
108MP0003890_abnormal_embryonic-extraembry0.91128427
109MP0005386_behavior/neurological_phenoty0.91058584
110MP0004924_abnormal_behavior0.91058584
111MP0003634_abnormal_glial_cell0.89256486
112MP0003635_abnormal_synaptic_transmissio0.88694474
113MP0002095_abnormal_skin_pigmentation0.85763814
114MP0003329_amyloid_beta_deposits0.85242777
115MP0002733_abnormal_thermal_nociception0.83976318
116MP0002090_abnormal_vision0.83789117
117MP0000653_abnormal_sex_gland0.83143162
118MP0008789_abnormal_olfactory_epithelium0.83054086
119MP0004145_abnormal_muscle_electrophysio0.82569490
120MP0000647_abnormal_sebaceous_gland0.82418571
121MP0003724_increased_susceptibility_to0.81460091
122MP0005195_abnormal_posterior_eye0.81280556
123MP0005391_vision/eye_phenotype0.81011533
124MP0002751_abnormal_autonomic_nervous0.80923706
125MP0001145_abnormal_male_reproductive0.80847335
126MP0005253_abnormal_eye_physiology0.80735622
127MP0003315_abnormal_perineum_morphology0.78832995
128MP0004957_abnormal_blastocyst_morpholog0.78496106
129MP0003137_abnormal_impulse_conducting0.77916827
130MP0008875_abnormal_xenobiotic_pharmacok0.76860001
131MP0001324_abnormal_eye_pigmentation0.76691537
132MP0002066_abnormal_motor_capabilities/c0.76106177
133MP0002184_abnormal_innervation0.74919060
134MP0001929_abnormal_gametogenesis0.74561425
135MP0005451_abnormal_body_composition0.74004340
136MP0002882_abnormal_neuron_morphology0.73861658
137MP0004133_heterotaxia0.73853916
138MP0002876_abnormal_thyroid_physiology0.73814795
139MP0002697_abnormal_eye_size0.73586797
140MP0001542_abnormal_bone_strength0.73469984
141MP0002837_dystrophic_cardiac_calcinosis0.72511664
142MP0001501_abnormal_sleep_pattern0.71490004
143MP0002063_abnormal_learning/memory/cond0.71432279
144MP0003195_calcinosis0.70661267
145MP0000762_abnormal_tongue_morphology0.69119991
146MP0008058_abnormal_DNA_repair0.69000113
147MP0002332_abnormal_exercise_endurance0.66142641
148MP0001984_abnormal_olfaction0.65568113
149MP0005164_abnormal_response_to0.65337130

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.92660939
2Abnormal mitochondria in muscle tissue (HP:0008316)6.05752560
3Mitochondrial inheritance (HP:0001427)5.87165607
4Progressive macrocephaly (HP:0004481)5.79243508
5Acute encephalopathy (HP:0006846)5.57695105
6Increased hepatocellular lipid droplets (HP:0006565)5.28972219
7Increased CSF lactate (HP:0002490)4.86770901
8Abnormality of cells of the erythroid lineage (HP:0012130)4.86124480
9Renal Fanconi syndrome (HP:0001994)4.73990624
10Lipid accumulation in hepatocytes (HP:0006561)4.62873796
11Hepatocellular necrosis (HP:0001404)4.54125523
123-Methylglutaconic aciduria (HP:0003535)4.32517819
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.28784841
14Parakeratosis (HP:0001036)4.28057247
15Abnormal number of erythroid precursors (HP:0012131)4.14905716
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.10597981
17Increased serum pyruvate (HP:0003542)4.00083211
18Abnormality of glycolysis (HP:0004366)4.00083211
19Leukodystrophy (HP:0002415)3.99394729
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.94430702
21Hepatic necrosis (HP:0002605)3.73633058
22Cerebral edema (HP:0002181)3.64889753
23Reticulocytopenia (HP:0001896)3.59865596
24Exertional dyspnea (HP:0002875)3.59507983
25Optic disc pallor (HP:0000543)3.57871821
26Increased intramyocellular lipid droplets (HP:0012240)3.43103171
27Exercise intolerance (HP:0003546)3.39814519
28Macrocytic anemia (HP:0001972)3.37783977
29Respiratory failure (HP:0002878)3.37687957
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.06090813
31Decreased activity of mitochondrial respiratory chain (HP:0008972)3.06090813
32Abnormality of renal resorption (HP:0011038)3.03803943
33Increased serum lactate (HP:0002151)3.03555841
34Congenital ichthyosiform erythroderma (HP:0007431)3.00670768
35Respiratory difficulties (HP:0002880)2.89375365
36Lactic acidosis (HP:0003128)2.87557362
37Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.82285522
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.82285522
39Pallor (HP:0000980)2.80196399
40Increased muscle lipid content (HP:0009058)2.72421923
41Molar tooth sign on MRI (HP:0002419)2.72074493
42Abnormality of midbrain morphology (HP:0002418)2.72074493
43Sensory axonal neuropathy (HP:0003390)2.70174730
44Pancreatic fibrosis (HP:0100732)2.69689320
45Cerebral hypomyelination (HP:0006808)2.66201537
46Pancreatic cysts (HP:0001737)2.58668179
47X-linked dominant inheritance (HP:0001423)2.53141419
48Amniotic constriction ring (HP:0009775)2.49513866
49Abnormality of placental membranes (HP:0011409)2.49513866
50True hermaphroditism (HP:0010459)2.46915297
51Abnormality of the anterior horn cell (HP:0006802)2.36842351
52Degeneration of anterior horn cells (HP:0002398)2.36842351
53Aplastic anemia (HP:0001915)2.34481824
54Stenosis of the external auditory canal (HP:0000402)2.33987148
55Methylmalonic aciduria (HP:0012120)2.28969435
56Colon cancer (HP:0003003)2.26268117
57Sclerocornea (HP:0000647)2.20941455
58CNS demyelination (HP:0007305)2.13916225
59Hyperglycinemia (HP:0002154)2.11491982
60Hypothermia (HP:0002045)2.08576768
61Retinal dysplasia (HP:0007973)2.07218686
62Glycosuria (HP:0003076)2.04297791
63Abnormality of urine glucose concentration (HP:0011016)2.04297791
64Microvesicular hepatic steatosis (HP:0001414)2.04106996
65Anencephaly (HP:0002323)2.01992954
66Hyperphosphaturia (HP:0003109)1.97804280
67Aplasia/hypoplasia of the uterus (HP:0008684)1.96864849
68Hyperalaninemia (HP:0003348)1.95806625
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95806625
70Abnormality of alanine metabolism (HP:0010916)1.95806625
71Type I transferrin isoform profile (HP:0003642)1.94122906
72Generalized aminoaciduria (HP:0002909)1.92880024
73Medial flaring of the eyebrow (HP:0010747)1.91735904
74Emotional lability (HP:0000712)1.88605123
75Abnormality of the labia minora (HP:0012880)1.88358140
76Nephronophthisis (HP:0000090)1.86550197
77Abnormality of secondary sexual hair (HP:0009888)1.85268295
78Abnormality of the axillary hair (HP:0100134)1.85268295
79Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81787471
80Abnormal pupillary function (HP:0007686)1.79332525
81Triphalangeal thumb (HP:0001199)1.75934448
82Duplicated collecting system (HP:0000081)1.75512910
83Blindness (HP:0000618)1.75447103
84Adrenal hypoplasia (HP:0000835)1.75324375
85Microretrognathia (HP:0000308)1.74681154
86Abnormal hemoglobin (HP:0011902)1.74321618
87Renal tubular dysfunction (HP:0000124)1.73376795
88Abnormal urine phosphate concentration (HP:0012599)1.72874342
89Congenital, generalized hypertrichosis (HP:0004540)1.71840400
90Absent thumb (HP:0009777)1.71700697
91Pendular nystagmus (HP:0012043)1.71405731
92Abnormality of the septum pellucidum (HP:0007375)1.70134772
93Pancytopenia (HP:0001876)1.69937620
94Type 2 muscle fiber atrophy (HP:0003554)1.69765965
95Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69640171
96Abnormal protein N-linked glycosylation (HP:0012347)1.69640171
97Abnormal protein glycosylation (HP:0012346)1.69640171
98Abnormal glycosylation (HP:0012345)1.69640171
99Neurofibrillary tangles (HP:0002185)1.69465412
100CNS hypomyelination (HP:0003429)1.68977557
101Hepatosplenomegaly (HP:0001433)1.67954679
102Lethargy (HP:0001254)1.67580942
103Oral leukoplakia (HP:0002745)1.67425956
104Patchy hypopigmentation of hair (HP:0011365)1.67396374
105Cerebral hemorrhage (HP:0001342)1.66559713
106Male pseudohermaphroditism (HP:0000037)1.65727273
107Cleft eyelid (HP:0000625)1.65613255
108Abnormality of serum amino acid levels (HP:0003112)1.64367236
109Abnormal ciliary motility (HP:0012262)1.64164269
110Abnormal number of incisors (HP:0011064)1.62975544
111Poor suck (HP:0002033)1.62231457
112Gait imbalance (HP:0002141)1.61827406
113Autoamputation (HP:0001218)1.61776117
114Absent septum pellucidum (HP:0001331)1.61742393
115Abnormal respiratory epithelium morphology (HP:0012253)1.61648019
116Abnormal respiratory motile cilium morphology (HP:0005938)1.61648019
117Delusions (HP:0000746)1.61195787
118Occipital encephalocele (HP:0002085)1.61187652
119Anophthalmia (HP:0000528)1.60644852
120Hypoplasia of the uterus (HP:0000013)1.60596873
121Septo-optic dysplasia (HP:0100842)1.60256393
122Limb dystonia (HP:0002451)1.59183816
123Meckel diverticulum (HP:0002245)1.58595086
124Abnormality of methionine metabolism (HP:0010901)1.58591812
125Congenital primary aphakia (HP:0007707)1.57485831
126Breast hypoplasia (HP:0003187)1.57413029
127Abnormality of the corticospinal tract (HP:0002492)1.57316066
128Delayed CNS myelination (HP:0002188)1.56726051
129Spastic paraparesis (HP:0002313)1.55585826
130Peripheral hypomyelination (HP:0007182)1.54562553
131Myokymia (HP:0002411)1.54059443
132Dynein arm defect of respiratory motile cilia (HP:0012255)1.53007743
133Absent/shortened dynein arms (HP:0200106)1.53007743
134Vaginal atresia (HP:0000148)1.51985159
135Methylmalonic acidemia (HP:0002912)1.51912186
136Abnormality of the renal collecting system (HP:0004742)1.51243561
137Partial duplication of thumb phalanx (HP:0009944)1.51030725
138Septate vagina (HP:0001153)1.50020143
139Erythroderma (HP:0001019)1.49046506
140Nephrogenic diabetes insipidus (HP:0009806)1.47405454
141Abnormal autonomic nervous system physiology (HP:0012332)1.47349613

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.64316183
2STK393.50283983
3PBK3.34127574
4MST43.16134558
5STK162.82319436
6NME22.71710736
7OXSR12.54292267
8CDC72.46083530
9BUB12.36546133
10PNCK2.28458773
11NME12.16973569
12MAP4K22.15676924
13CASK2.13642293
14VRK12.02824118
15CDK192.00986959
16TNIK1.95785253
17NUAK11.92135835
18MAP3K121.88913577
19GRK71.87652505
20BCKDK1.85090925
21MAPKAPK51.84008486
22BCR1.73476912
23WNK41.72760816
24TLK11.71230619
25LIMK11.59921044
26MUSK1.55303914
27NEK11.54247659
28TRIM281.53858313
29TESK21.53699438
30PDK21.52031406
31WEE11.51099550
32DYRK21.50085868
33EIF2AK11.48300843
34TAF11.44656723
35ADRBK21.42952661
36SRPK11.40287086
37BMPR21.40202168
38EIF2AK31.35317167
39PKN11.32103496
40ARAF1.28317945
41MKNK11.28274525
42GRK51.25415053
43BMPR1B1.25340142
44UHMK11.23764114
45CAMK2B1.16722916
46CSNK1G31.13893338
47TTK1.07373722
48FGR1.07250779
49PIM21.06460441
50IRAK21.06221635
51PLK41.05454621
52CAMK2D1.01692267
53MAP3K40.98720128
54ABL20.97478732
55INSRR0.94758532
56MYLK0.91006316
57AURKB0.90178239
58MAPK130.88917806
59MAP2K70.87745542
60IRAK40.87447107
61CHEK20.84842427
62RIPK40.83673633
63FRK0.82906857
64RPS6KA50.82211353
65PRKCG0.78181239
66AURKA0.77194445
67CAMK2A0.77072230
68YES10.76757780
69ILK0.75891767
70PLK20.75882132
71PINK10.75869945
72EIF2AK20.74260950
73MARK10.72772452
74BLK0.72214488
75CAMK2G0.69697956
76MET0.67879516
77CSNK1G10.67791041
78BRSK20.66642389
79ROCK20.66485997
80CDK80.66366227
81ATR0.66107841
82DAPK10.64543428
83BRSK10.62654306
84CSNK1A1L0.61817328
85ADRBK10.61772848
86MKNK20.59868304
87NEK60.58859908
88MINK10.58189812
89PHKG20.57929638
90PHKG10.57929638
91MOS0.57886002
92PRKCE0.56116579
93CDK140.54705381
94PLK30.54674482
95* CSNK2A20.54264866
96* CSNK2A10.53014091
97PAK10.52401498
98ERBB30.52303549
99TESK10.51976909
100CSNK1G20.51925731
101RPS6KA40.51448991
102PASK0.50593233
103CDK30.50154083
104EPHB20.49764366
105IRAK10.49415824
106CSNK1A10.49319772
107TSSK60.49247235
108EPHB10.49146049
109TIE10.49127522
110WNK10.49084124
111GRK10.47534178
112MAPK150.45948414
113ZAK0.45180122
114CDK150.44357277
115CDK180.43961430
116OBSCN0.43552286
117CDK11A0.43427428
118STK40.42454631
119ATM0.42215952
120PRKACA0.41976860
121CSNK1E0.41782830
122WNK30.40844246
123DYRK30.40545687
124CLK10.39897595
125DAPK30.39561074
126KDR0.39327767
127LRRK20.38510684
128PAK30.38303626
129EPHA40.37904634
130ERBB40.37053737
131PLK10.36916323
132CCNB10.36675477
133PRKCI0.36535414
134BRD40.36181906
135PIK3CA0.36005315
136MST1R0.34851520
137LYN0.34833866
138IKBKB0.34489724
139IRAK30.31478988
140PRKG10.31419791
141PRKCD0.31202767
142PRKCQ0.31130792

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.54271850
2Ribosome_Homo sapiens_hsa030104.97402903
3Parkinsons disease_Homo sapiens_hsa050124.61093832
4Proteasome_Homo sapiens_hsa030503.97508921
5Alzheimers disease_Homo sapiens_hsa050103.48701980
6Protein export_Homo sapiens_hsa030603.43563991
7Huntingtons disease_Homo sapiens_hsa050163.32800692
8RNA polymerase_Homo sapiens_hsa030203.23424164
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.90145106
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.86394205
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07785893
12Cardiac muscle contraction_Homo sapiens_hsa042601.98700922
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89962590
14Fatty acid elongation_Homo sapiens_hsa000621.83269995
15Steroid biosynthesis_Homo sapiens_hsa001001.77518862
16Collecting duct acid secretion_Homo sapiens_hsa049661.69074108
17Pyrimidine metabolism_Homo sapiens_hsa002401.56470823
18Spliceosome_Homo sapiens_hsa030401.50102909
19One carbon pool by folate_Homo sapiens_hsa006701.44528933
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38480303
21Ether lipid metabolism_Homo sapiens_hsa005651.36502689
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33222866
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31759924
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22071855
25Basal transcription factors_Homo sapiens_hsa030221.21053458
26Sulfur metabolism_Homo sapiens_hsa009201.19949574
27Homologous recombination_Homo sapiens_hsa034401.17046616
28Vibrio cholerae infection_Homo sapiens_hsa051101.15893224
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11661753
30Rheumatoid arthritis_Homo sapiens_hsa053231.07046084
31Nucleotide excision repair_Homo sapiens_hsa034201.06431211
32DNA replication_Homo sapiens_hsa030301.05986039
33Mismatch repair_Homo sapiens_hsa034301.05689719
34Propanoate metabolism_Homo sapiens_hsa006401.04026066
35Purine metabolism_Homo sapiens_hsa002301.00546120
36Glutathione metabolism_Homo sapiens_hsa004800.98381130
37Linoleic acid metabolism_Homo sapiens_hsa005910.94888706
38Arachidonic acid metabolism_Homo sapiens_hsa005900.93992515
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93349197
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92763259
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90425447
42Folate biosynthesis_Homo sapiens_hsa007900.85515471
43Histidine metabolism_Homo sapiens_hsa003400.84504047
44Metabolic pathways_Homo sapiens_hsa011000.78114951
45Sphingolipid metabolism_Homo sapiens_hsa006000.77625659
46Non-homologous end-joining_Homo sapiens_hsa034500.77008571
47Vitamin B6 metabolism_Homo sapiens_hsa007500.76907915
48Serotonergic synapse_Homo sapiens_hsa047260.76603514
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.75312099
50Phototransduction_Homo sapiens_hsa047440.70459246
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69798998
52Phagosome_Homo sapiens_hsa041450.68828463
53Graft-versus-host disease_Homo sapiens_hsa053320.68772257
54RNA degradation_Homo sapiens_hsa030180.68144083
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66239013
56Nicotine addiction_Homo sapiens_hsa050330.65850048
57RNA transport_Homo sapiens_hsa030130.64910170
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64597306
59Tryptophan metabolism_Homo sapiens_hsa003800.64128802
60Cell cycle_Homo sapiens_hsa041100.63855092
61Autoimmune thyroid disease_Homo sapiens_hsa053200.63700240
62Allograft rejection_Homo sapiens_hsa053300.62976260
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62271306
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59585211
65Fanconi anemia pathway_Homo sapiens_hsa034600.59081826
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58551585
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56555628
68Asthma_Homo sapiens_hsa053100.56240248
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.53667533
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51821375
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.51226891
72Sulfur relay system_Homo sapiens_hsa041220.51023579
73Tyrosine metabolism_Homo sapiens_hsa003500.50689288
74Base excision repair_Homo sapiens_hsa034100.50273361
75Selenocompound metabolism_Homo sapiens_hsa004500.47659264
76Arginine and proline metabolism_Homo sapiens_hsa003300.47482138
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47473977
78Nitrogen metabolism_Homo sapiens_hsa009100.47058077
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45427647
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43071454
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41730005
82Epstein-Barr virus infection_Homo sapiens_hsa051690.41478650
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41229037
84Carbon metabolism_Homo sapiens_hsa012000.40079914
85beta-Alanine metabolism_Homo sapiens_hsa004100.39987910
86Phenylalanine metabolism_Homo sapiens_hsa003600.39629337
87Chemical carcinogenesis_Homo sapiens_hsa052040.38401906
88Regulation of autophagy_Homo sapiens_hsa041400.37815522
89Systemic lupus erythematosus_Homo sapiens_hsa053220.35233559
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34299461
91Basal cell carcinoma_Homo sapiens_hsa052170.33580445
92p53 signaling pathway_Homo sapiens_hsa041150.32773549
93Fatty acid degradation_Homo sapiens_hsa000710.32304382
94GABAergic synapse_Homo sapiens_hsa047270.31918674
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31486728
96Hedgehog signaling pathway_Homo sapiens_hsa043400.31185033
97Caffeine metabolism_Homo sapiens_hsa002320.30857030
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28678449
99Oocyte meiosis_Homo sapiens_hsa041140.28646807
100Biosynthesis of amino acids_Homo sapiens_hsa012300.28253313
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27744905
102Fatty acid metabolism_Homo sapiens_hsa012120.27609918
103Vitamin digestion and absorption_Homo sapiens_hsa049770.26422337
104Olfactory transduction_Homo sapiens_hsa047400.25880170
105Mineral absorption_Homo sapiens_hsa049780.25592063
106Fat digestion and absorption_Homo sapiens_hsa049750.25573033
107Synaptic vesicle cycle_Homo sapiens_hsa047210.25389459
108Morphine addiction_Homo sapiens_hsa050320.24780482
109Alcoholism_Homo sapiens_hsa050340.23949392
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23388183
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23277721
112Glutamatergic synapse_Homo sapiens_hsa047240.22694726
113Taste transduction_Homo sapiens_hsa047420.22139810
114mRNA surveillance pathway_Homo sapiens_hsa030150.21067890
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20659745
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20633540
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19883341
118Pyruvate metabolism_Homo sapiens_hsa006200.18975930
119Butanoate metabolism_Homo sapiens_hsa006500.18544711
120Type I diabetes mellitus_Homo sapiens_hsa049400.18181667
121African trypanosomiasis_Homo sapiens_hsa051430.17864431
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16337964
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.15111350
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.14436715
125Malaria_Homo sapiens_hsa051440.12914662
126Long-term depression_Homo sapiens_hsa047300.11133400
127Hematopoietic cell lineage_Homo sapiens_hsa046400.10843336
128Pertussis_Homo sapiens_hsa051330.09775516
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.09308718
130Axon guidance_Homo sapiens_hsa043600.09098817
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06023398
132Retinol metabolism_Homo sapiens_hsa008300.05980272
133Peroxisome_Homo sapiens_hsa041460.02606741
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.02515761

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