PIM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.41557360
2positive regulation of gamma-delta T cell activation (GO:0046645)5.33840029
3antigen processing and presentation of endogenous antigen (GO:0019883)5.18987679
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.14653798
5regulation of B cell receptor signaling pathway (GO:0050855)5.03637035
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.93348936
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.89595832
8negative T cell selection (GO:0043383)4.83721851
9negative thymic T cell selection (GO:0045060)4.76021556
10positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.68173558
11folic acid-containing compound biosynthetic process (GO:0009396)4.62737493
12positive regulation of histone H3-K4 methylation (GO:0051571)4.55756777
13T cell migration (GO:0072678)4.49044831
14pre-miRNA processing (GO:0031054)4.31770077
15establishment of integrated proviral latency (GO:0075713)4.29089146
16maturation of SSU-rRNA (GO:0030490)4.25133740
17tolerance induction (GO:0002507)4.24429251
18viral transcription (GO:0019083)4.21167629
19regulation of gamma-delta T cell activation (GO:0046643)4.16795801
20DNA unwinding involved in DNA replication (GO:0006268)4.16421865
21regulation of gamma-delta T cell differentiation (GO:0045586)4.12867379
22translational termination (GO:0006415)4.12822196
23formation of translation preinitiation complex (GO:0001731)4.07732932
24positive thymic T cell selection (GO:0045059)4.05604387
25regulation of posttranscriptional gene silencing (GO:0060147)4.03794205
26regulation of gene silencing by miRNA (GO:0060964)4.03794205
27regulation of gene silencing by RNA (GO:0060966)4.03794205
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.97619832
29ribosomal small subunit assembly (GO:0000028)3.96216164
30thymic T cell selection (GO:0045061)3.95968817
31cotranslational protein targeting to membrane (GO:0006613)3.88334604
32protein targeting to ER (GO:0045047)3.86890230
33peptidyl-arginine omega-N-methylation (GO:0035247)3.86266080
34translational elongation (GO:0006414)3.86191338
35DNA deamination (GO:0045006)3.85521544
36ribosomal large subunit biogenesis (GO:0042273)3.82977608
37regulation of alpha-beta T cell proliferation (GO:0046640)3.81874534
38cytidine deamination (GO:0009972)3.77332330
39cytidine metabolic process (GO:0046087)3.77332330
40cytidine catabolic process (GO:0006216)3.77332330
41B cell receptor signaling pathway (GO:0050853)3.73690114
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.68003166
43protein complex localization (GO:0031503)3.67256390
44positive T cell selection (GO:0043368)3.66462413
45translational initiation (GO:0006413)3.64253846
46protein localization to endoplasmic reticulum (GO:0070972)3.63874420
47ribosome biogenesis (GO:0042254)3.63176322
48regulation of interleukin-2 biosynthetic process (GO:0045076)3.62483545
49cellular response to type I interferon (GO:0071357)3.62296314
50type I interferon signaling pathway (GO:0060337)3.62296314
51positive regulation of alpha-beta T cell proliferation (GO:0046641)3.62254276
52ribonucleoprotein complex biogenesis (GO:0022613)3.62001347
53regulation of T cell mediated cytotoxicity (GO:0001914)3.61726460
54ribosomal small subunit biogenesis (GO:0042274)3.61393047
55immunoglobulin mediated immune response (GO:0016064)3.59137649
56response to type I interferon (GO:0034340)3.58806150
57positive regulation of B cell differentiation (GO:0045579)3.56162218
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55840862
59T cell selection (GO:0045058)3.54536444
60positive regulation of T cell mediated cytotoxicity (GO:0001916)3.53833427
61regulation of regulatory T cell differentiation (GO:0045589)3.53651106
62nucleobase biosynthetic process (GO:0046112)3.52429024
63NIK/NF-kappaB signaling (GO:0038061)3.52218910
64establishment of viral latency (GO:0019043)3.51149089
65histone arginine methylation (GO:0034969)3.50280722
66regulation of B cell differentiation (GO:0045577)3.50231479
67negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.50220289
68pseudouridine synthesis (GO:0001522)3.49893487
69CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.49755789
70pyrimidine ribonucleoside catabolic process (GO:0046133)3.49054355
71IMP biosynthetic process (GO:0006188)3.48017005
72regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.45319035
73regulation of natural killer cell mediated immunity (GO:0002715)3.45319035
74B cell mediated immunity (GO:0019724)3.38696717
75pteridine-containing compound biosynthetic process (GO:0042559)3.36951832
76viral life cycle (GO:0019058)3.36891712
77B cell homeostasis (GO:0001782)3.36561464
78regulation of leukocyte mediated cytotoxicity (GO:0001910)3.33410555
79negative regulation of T cell mediated immunity (GO:0002710)3.32058692
80spliceosomal snRNP assembly (GO:0000387)3.28873247
81negative regulation of histone methylation (GO:0031061)3.28671230
82cellular protein complex disassembly (GO:0043624)3.28317642
83positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.28265996
84Golgi transport vesicle coating (GO:0048200)3.27000092
85COPI coating of Golgi vesicle (GO:0048205)3.27000092
86DNA strand elongation involved in DNA replication (GO:0006271)3.22469440
87regulation of cell killing (GO:0031341)3.21376043
88peptidyl-arginine methylation (GO:0018216)3.20801648
89peptidyl-arginine N-methylation (GO:0035246)3.20801648
90negative regulation of lymphocyte mediated immunity (GO:0002707)3.20543450
91antigen receptor-mediated signaling pathway (GO:0050851)3.19215819
92positive regulation of cell killing (GO:0031343)3.19039994
93regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.18272246
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.18227456
95positive regulation of interleukin-2 production (GO:0032743)3.17096377
96T cell costimulation (GO:0031295)3.15282716
97protein complex disassembly (GO:0043241)3.15268818
98regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.15060501
99ribosome assembly (GO:0042255)3.14719530
100rRNA processing (GO:0006364)3.13928327
101histone H2A acetylation (GO:0043968)3.13371360
102DNA replication initiation (GO:0006270)3.12784677
103positive regulation of defense response to virus by host (GO:0002230)3.12421831
104gonadal mesoderm development (GO:0007506)3.11760618
105lymphocyte costimulation (GO:0031294)3.10929223
106signal transduction involved in regulation of gene expression (GO:0023019)3.09490746
107mast cell activation (GO:0045576)3.08961059
108interferon-gamma-mediated signaling pathway (GO:0060333)3.07670968
109spliceosomal complex assembly (GO:0000245)3.07040491
110DNA strand elongation (GO:0022616)3.06640106
111regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.05967573
112lymphocyte homeostasis (GO:0002260)3.05649305
113negative regulation of B cell proliferation (GO:0030889)3.05538305
114detection of bacterium (GO:0016045)3.05415312
115leukocyte aggregation (GO:0070486)3.04616668
116rRNA metabolic process (GO:0016072)3.04488971
117negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03797529
118regulation of histone H3-K4 methylation (GO:0051569)3.02451831
119response to muramyl dipeptide (GO:0032495)3.01832667
120negative regulation of leukocyte mediated immunity (GO:0002704)3.01703226
121dendritic cell chemotaxis (GO:0002407)3.01614377
122defense response to protozoan (GO:0042832)3.01350649
123macromolecular complex disassembly (GO:0032984)3.01346403
124T cell receptor signaling pathway (GO:0050852)3.01340767
125negative regulation of RNA splicing (GO:0033119)3.00664426
126positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.99969723
127L-alpha-amino acid transmembrane transport (GO:1902475)2.99303753
128translation (GO:0006412)2.98545422
129positive regulation of granulocyte differentiation (GO:0030854)2.98240036
130regulation of isotype switching to IgG isotypes (GO:0048302)2.97547928
131purine nucleobase biosynthetic process (GO:0009113)2.95720877
132myeloid dendritic cell activation (GO:0001773)2.93890703
133nuclear-transcribed mRNA catabolic process (GO:0000956)2.93702699
134regulation of translational fidelity (GO:0006450)2.93698172
135regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93036047
136IMP metabolic process (GO:0046040)2.92377185
137positive regulation of T cell mediated immunity (GO:0002711)2.91396943
138viral mRNA export from host cell nucleus (GO:0046784)2.90549515
139regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.89587303
140regulation of protein heterodimerization activity (GO:0043497)2.88642916
141positive regulation of natural killer cell mediated immunity (GO:0002717)2.88444738
142myeloid dendritic cell differentiation (GO:0043011)2.87983361
143negative regulation of viral genome replication (GO:0045071)2.87638046
144negative regulation of innate immune response (GO:0045824)2.87539577
145regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.87182406
146lymphocyte migration (GO:0072676)2.86699735
147regulation of T cell tolerance induction (GO:0002664)2.85101266
148regulation of antigen processing and presentation (GO:0002577)2.84748366
149antigen processing and presentation via MHC class Ib (GO:0002475)2.84721841
150detection of other organism (GO:0098543)2.84511166
151RNA splicing, via transesterification reactions (GO:0000375)2.83957231
152mRNA splicing, via spliceosome (GO:0000398)2.83229741
153RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.83229741
154Peyers patch development (GO:0048541)2.83091889
155mucosal-associated lymphoid tissue development (GO:0048537)2.83091889
156regulation of T cell mediated immunity (GO:0002709)2.82796754
157CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.82118719
158T-helper cell differentiation (GO:0042093)2.82118719
159T cell homeostasis (GO:0043029)2.81206851
160response to interferon-beta (GO:0035456)2.81131796
161positive regulation of antigen processing and presentation (GO:0002579)2.80334054
162DNA strand renaturation (GO:0000733)2.79483355
163germinal center formation (GO:0002467)2.79405419
164mRNA catabolic process (GO:0006402)2.78884811
165RNA catabolic process (GO:0006401)2.78268401
166ribonucleoprotein complex assembly (GO:0022618)2.75919057
167mitotic nuclear envelope disassembly (GO:0007077)2.73354626
168termination of RNA polymerase II transcription (GO:0006369)2.73198758
169interferon-gamma production (GO:0032609)2.72761378
170telomere maintenance via semi-conservative replication (GO:0032201)2.71853331
171cellular component biogenesis (GO:0044085)2.70698338
172ncRNA catabolic process (GO:0034661)2.70555910
173exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67445001
174DNA duplex unwinding (GO:0032508)2.67008599
175nodal signaling pathway (GO:0038092)2.66891359
176ribonucleoprotein complex subunit organization (GO:0071826)2.66358708
177negative regulation of cell killing (GO:0031342)2.65412964
178negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.65412964
179DNA geometric change (GO:0032392)2.65014648
180transcription elongation from RNA polymerase III promoter (GO:0006385)2.63664914
181termination of RNA polymerase III transcription (GO:0006386)2.63664914
182negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.63366094
183negative regulation of gene silencing (GO:0060969)2.62468678
184cellular response to interleukin-15 (GO:0071350)2.61960459
185regulation of histone H3-K9 methylation (GO:0051570)2.61725603
186tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.61495842
187RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.61495842
188tRNA aminoacylation for protein translation (GO:0006418)2.59579575
189nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57898480
190response to interleukin-15 (GO:0070672)2.56909192
191membrane disassembly (GO:0030397)2.56873533
192nuclear envelope disassembly (GO:0051081)2.56873533
193negative regulation of mRNA processing (GO:0050686)2.56455203
194rRNA modification (GO:0000154)2.55586618
195positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.55567597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.27057236
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.98257140
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.48971062
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.07968872
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.04017458
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.94829054
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.56221306
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24180650
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.21956163
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.15840905
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.05392816
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02101165
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.97520503
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91780408
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87577798
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86583616
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.78244146
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.73070662
19MYC_22102868_ChIP-Seq_BL_Human2.69811201
20XRN2_22483619_ChIP-Seq_HELA_Human2.69279602
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.68145039
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.67162994
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67047688
24RUNX_20019798_ChIP-Seq_JUKART_Human2.59019489
25* MYB_26560356_Chip-Seq_TH1_Human2.47502653
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.39709119
27VDR_23849224_ChIP-Seq_CD4+_Human2.36579454
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33475856
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28347317
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26101499
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.22351830
32FOXP3_21729870_ChIP-Seq_TREG_Human2.19301899
33CIITA_25753668_ChIP-Seq_RAJI_Human2.18883575
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16672205
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10754667
36GABP_19822575_ChIP-Seq_HepG2_Human2.09828202
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06609648
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01601171
39E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01297634
40* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98740066
41TTF2_22483619_ChIP-Seq_HELA_Human1.97213641
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.91261721
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90329276
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86082989
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84348412
46* GATA3_27048872_Chip-Seq_THYMUS_Human1.81628016
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79930565
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.78975308
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.78935120
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77639883
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77286086
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76842805
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75685952
54SCL_19346495_ChIP-Seq_HPC-7_Human1.75193829
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.72392058
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71474239
57DCP1A_22483619_ChIP-Seq_HELA_Human1.71045496
58* IRF8_27001747_Chip-Seq_BMDM_Mouse1.67366093
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.66648549
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65810933
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65186117
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63242672
63VDR_24763502_ChIP-Seq_THP-1_Human1.58980167
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.58602881
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.58469487
66NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57376043
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57298849
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57253775
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57109116
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55846166
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52268821
72ELK1_19687146_ChIP-ChIP_HELA_Human1.50761463
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50567248
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50540444
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50031095
76KDM5A_27292631_Chip-Seq_BREAST_Human1.49452612
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47495930
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.43868256
79GATA3_26560356_Chip-Seq_TH2_Human1.43174677
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42599871
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.41387557
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41120484
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35654085
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.35316092
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34663143
86VDR_21846776_ChIP-Seq_THP-1_Human1.33830482
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33264692
88TFEB_21752829_ChIP-Seq_HELA_Human1.33232572
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32697670
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30801342
91* TCF7_22412390_ChIP-Seq_EML_Mouse1.30669114
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27130570
93* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26077641
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25805944
95* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25312648
96HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24541278
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24420704
98GATA1_22025678_ChIP-Seq_K562_Human1.23781071
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22476712
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21727274
101SRF_21415370_ChIP-Seq_HL-1_Mouse1.20029259
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18867259
103KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16315498
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15173060
105CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14823971
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14775966
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14315118
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12471669
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12453166
110SPI1_23127762_ChIP-Seq_K562_Human1.12370663
111MYC_18940864_ChIP-ChIP_HL60_Human1.12249068
112LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11812471
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11764881
114PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09480368
115KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08478396
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07726304
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07689618
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07423652
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07318808
120NCOR1_26117541_ChIP-Seq_K562_Human1.06826750
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05474346
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03941240
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01652414
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01262961
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01254639
126BCL6_27268052_Chip-Seq_Bcells_Human0.99832907
127IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99026544
128UTX_26944678_Chip-Seq_JUKART_Human0.98964091
129RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98662224
130CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97931956
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96437400
132MAF_26560356_Chip-Seq_TH2_Human0.96133426
133FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96049516
134KDM2B_26808549_Chip-Seq_DND41_Human0.95751232
135CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94729346
136SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93609597
137FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93330700
138PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93176235
139BCOR_27268052_Chip-Seq_Bcells_Human0.93055425
140SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92667851
141FOXP1_21924763_ChIP-Seq_HESCs_Human0.92471358
142* MYB_26560356_Chip-Seq_TH2_Human0.92131965
143CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91952797
144SPI1_23547873_ChIP-Seq_NB4_Human0.91123840
145MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89366194
146PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88603718
147* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88542313
148CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87561540
149* MAF_26560356_Chip-Seq_TH1_Human0.87170522
150STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85596007
151ELK1_22589737_ChIP-Seq_MCF10A_Human0.85186936
152TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84402591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.25386340
2MP0008877_abnormal_DNA_methylation3.95953024
3MP0004957_abnormal_blastocyst_morpholog3.59618033
4MP0003436_decreased_susceptibility_to3.45526358
5MP0003890_abnormal_embryonic-extraembry3.27397761
6MP0003077_abnormal_cell_cycle2.91039221
7MP0003123_paternal_imprinting2.87455768
8MP0009785_altered_susceptibility_to2.71325729
9MP0010094_abnormal_chromosome_stability2.69888002
10MP0003724_increased_susceptibility_to2.68846697
11MP0005025_abnormal_response_to2.64938697
12MP0006292_abnormal_olfactory_placode2.64688495
13MP0002148_abnormal_hypersensitivity_rea2.60407063
14MP0004133_heterotaxia2.54514331
15MP0003303_peritoneal_inflammation2.52643965
16MP0003763_abnormal_thymus_physiology2.51449181
17MP0003111_abnormal_nucleus_morphology2.50652784
18MP0000013_abnormal_adipose_tissue2.29949685
19MP0005671_abnormal_response_to2.21886272
20MP0008058_abnormal_DNA_repair2.17998853
21MP0001730_embryonic_growth_arrest2.15365850
22MP0010155_abnormal_intestine_physiology2.13964221
23MP0002419_abnormal_innate_immunity2.12897724
24MP0002166_altered_tumor_susceptibility2.08316194
25MP0003183_abnormal_peptide_metabolism2.03592918
26MP0001873_stomach_inflammation2.03005295
27MP0008932_abnormal_embryonic_tissue2.00622757
28MP0006072_abnormal_retinal_apoptosis1.98471726
29MP0000678_abnormal_parathyroid_gland1.93670360
30MP0005645_abnormal_hypothalamus_physiol1.87651690
31MP0008057_abnormal_DNA_replication1.87495922
32MP0004947_skin_inflammation1.82655678
33MP0002693_abnormal_pancreas_physiology1.80961976
34MP0003119_abnormal_digestive_system1.80511017
35MP0000703_abnormal_thymus_morphology1.79896060
36MP0001845_abnormal_inflammatory_respons1.77637064
37MP0003121_genomic_imprinting1.74732466
38MP0003122_maternal_imprinting1.70496008
39MP0010352_gastrointestinal_tract_polyps1.68679525
40MP0001944_abnormal_pancreas_morphology1.67672640
41MP0008007_abnormal_cellular_replicative1.67461963
42MP0000465_gastrointestinal_hemorrhage1.64751339
43MP0002909_abnormal_adrenal_gland1.63247164
44MP0002006_tumorigenesis1.62299334
45* MP0002398_abnormal_bone_marrow1.60045974
46MP0000350_abnormal_cell_proliferation1.59278600
47MP0006082_CNS_inflammation1.58355990
48MP0002254_reproductive_system_inflammat1.55010422
49MP0001697_abnormal_embryo_size1.53349704
50MP0005464_abnormal_platelet_physiology1.52642500
51MP0009333_abnormal_splenocyte_physiolog1.48546406
52MP0003300_gastrointestinal_ulcer1.48179830
53MP0001533_abnormal_skeleton_physiology1.44743195
54MP0001853_heart_inflammation1.44600877
55MP0001800_abnormal_humoral_immune1.44139376
56MP0002722_abnormal_immune_system1.43097549
57MP0002084_abnormal_developmental_patter1.42486459
58MP0002138_abnormal_hepatobiliary_system1.39309348
59MP0000685_abnormal_immune_system1.38559173
60MP0000689_abnormal_spleen_morphology1.35413063
61MP0000313_abnormal_cell_death1.34777551
62MP0003283_abnormal_digestive_organ1.33787540
63MP0003866_abnormal_defecation1.31015158
64MP0002080_prenatal_lethality1.28090603
65MP0002163_abnormal_gland_morphology1.27264998
66MP0001672_abnormal_embryogenesis/_devel1.26996440
67MP0005380_embryogenesis_phenotype1.26996440
68MP0001529_abnormal_vocalization1.26818165
69MP0000003_abnormal_adipose_tissue1.26490482
70MP0002751_abnormal_autonomic_nervous1.25763391
71MP0002234_abnormal_pharynx_morphology1.25669848
72* MP0000716_abnormal_immune_system1.22290466
73MP0002085_abnormal_embryonic_tissue1.20904331
74MP0008469_abnormal_protein_level1.20547252
75MP0009672_abnormal_birth_weight1.20450396
76MP0002933_joint_inflammation1.17042992
77* MP0002723_abnormal_immune_serum1.16327205
78MP0002009_preneoplasia1.14141662
79MP0005387_immune_system_phenotype1.13822519
80MP0001790_abnormal_immune_system1.13822519
81* MP0002420_abnormal_adaptive_immunity1.13032413
82* MP0002429_abnormal_blood_cell1.12863043
83MP0002019_abnormal_tumor_incidence1.12634015
84MP0001986_abnormal_taste_sensitivity1.12503753
85MP0002638_abnormal_pupillary_reflex1.12472009
86MP0003787_abnormal_imprinting1.12383565
87* MP0001819_abnormal_immune_cell1.10749426
88MP0002653_abnormal_ependyma_morphology1.10293059
89MP0003984_embryonic_growth_retardation1.08974002
90MP0002088_abnormal_embryonic_growth/wei1.06056654
91MP0002396_abnormal_hematopoietic_system1.06054082
92MP0010307_abnormal_tumor_latency1.04341002
93MP0005000_abnormal_immune_tolerance1.03986506
94MP0005220_abnormal_exocrine_pancreas1.03918659
95MP0005379_endocrine/exocrine_gland_phen1.03889816
96MP0008961_abnormal_basal_metabolism1.03631515
97MP0009278_abnormal_bone_marrow1.03115428
98MP0009764_decreased_sensitivity_to1.00655457
99MP0004264_abnormal_extraembryonic_tissu0.99059271
100MP0004808_abnormal_hematopoietic_stem0.95802118
101MP0001835_abnormal_antigen_presentation0.95513366
102MP0005075_abnormal_melanosome_morpholog0.94665044
103MP0002452_abnormal_antigen_presenting0.94613324
104MP0000358_abnormal_cell_content/0.92826361
105MP0000490_abnormal_crypts_of0.91720820
106MP0005499_abnormal_olfactory_system0.90562850
107MP0005394_taste/olfaction_phenotype0.90562850
108MP0002405_respiratory_system_inflammati0.89041594
109MP0002086_abnormal_extraembryonic_tissu0.87630576
110MP0001348_abnormal_lacrimal_gland0.85134698
111MP0009763_increased_sensitivity_to0.84780727
112MP0002160_abnormal_reproductive_system0.84108515
113MP0004381_abnormal_hair_follicle0.83721716
114MP0002277_abnormal_respiratory_mucosa0.82996114
115MP0004197_abnormal_fetal_growth/weight/0.82856616
116MP0001919_abnormal_reproductive_system0.81005887
117MP0005451_abnormal_body_composition0.80669467
118MP0004233_abnormal_muscle_weight0.80302775
119MP0003656_abnormal_erythrocyte_physiolo0.79582452
120MP0009765_abnormal_xenobiotic_induced0.79238497
121MP0001293_anophthalmia0.79167591
122MP0008789_abnormal_olfactory_epithelium0.78275412
123MP0002998_abnormal_bone_remodeling0.76032790
124MP0004270_analgesia0.75349635
125MP0003786_premature_aging0.74686415
126MP0001851_eye_inflammation0.72949538
127MP0005310_abnormal_salivary_gland0.72678250
128MP0000858_altered_metastatic_potential0.72605894
129MP0008995_early_reproductive_senescence0.72274107
130MP0009703_decreased_birth_body0.71776861
131MP0001663_abnormal_digestive_system0.71713992
132MP0003448_altered_tumor_morphology0.71386732
133MP0005076_abnormal_cell_differentiation0.66620860
134MP0002132_abnormal_respiratory_system0.65472834
135MP0001545_abnormal_hematopoietic_system0.65461028
136MP0005397_hematopoietic_system_phenotyp0.65461028
137MP0005384_cellular_phenotype0.63976320
138MP0008260_abnormal_autophagy0.63574227
139MP0010234_abnormal_vibrissa_follicle0.63137532
140MP0002078_abnormal_glucose_homeostasis0.60995015
141MP0005389_reproductive_system_phenotype0.60977480
142MP0003959_abnormal_lean_body0.60528627
143MP0002938_white_spotting0.59638241
144MP0003172_abnormal_lysosome_physiology0.56940384
145MP0006035_abnormal_mitochondrial_morpho0.53646825
146MP0003045_fibrosis0.53577683
147MP0000609_abnormal_liver_physiology0.52092512
148MP0003806_abnormal_nucleotide_metabolis0.51810570
149MP0000372_irregular_coat_pigmentation0.51396534
150MP0005390_skeleton_phenotype0.48582296
151MP0002136_abnormal_kidney_physiology0.46300051
152MP0003795_abnormal_bone_structure0.46045464
153MP0008873_increased_physiological_sensi0.45142847

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.54666237
2Meningitis (HP:0001287)4.30597859
3Gastrointestinal stroma tumor (HP:0100723)4.28149180
4Eczematoid dermatitis (HP:0000976)4.26989887
5Agammaglobulinemia (HP:0004432)4.25476258
6Abnormality of T cell number (HP:0011839)4.15864642
7Vasculitis (HP:0002633)4.05758504
8Colon cancer (HP:0003003)3.97391037
9Panhypogammaglobulinemia (HP:0003139)3.95346554
10Recurrent fungal infections (HP:0002841)3.89085073
11Myositis (HP:0100614)3.88840769
12Increased IgM level (HP:0003496)3.85130312
13Recurrent viral infections (HP:0004429)3.83592793
14Stomatitis (HP:0010280)3.82242370
15Retrobulbar optic neuritis (HP:0100654)3.82035752
16Optic neuritis (HP:0100653)3.82035752
17Mediastinal lymphadenopathy (HP:0100721)3.76952625
18Recurrent cutaneous fungal infections (HP:0011370)3.74174215
19Chronic mucocutaneous candidiasis (HP:0002728)3.74174215
20IgA deficiency (HP:0002720)3.68453172
21Autoimmune hemolytic anemia (HP:0001890)3.62253085
22Elevated erythrocyte sedimentation rate (HP:0003565)3.58592791
23Encephalitis (HP:0002383)3.56876986
24Birth length less than 3rd percentile (HP:0003561)3.52853473
25Orchitis (HP:0100796)3.51380267
26Recurrent sinusitis (HP:0011108)3.43295404
27Recurrent bacterial skin infections (HP:0005406)3.39635025
28Chronic bronchitis (HP:0004469)3.38515662
29Abnormality of T cells (HP:0002843)3.33583005
30Pulmonary infiltrates (HP:0002113)3.32786630
31Chronic diarrhea (HP:0002028)3.30162445
32Reticulocytopenia (HP:0001896)3.28741021
33Abnormality of macrophages (HP:0004311)3.26421917
34Obstructive lung disease (HP:0006536)3.25249531
35Chronic obstructive pulmonary disease (HP:0006510)3.25249531
36Late onset (HP:0003584)3.24903392
37Recurrent abscess formation (HP:0002722)3.24803853
38Combined immunodeficiency (HP:0005387)3.20187992
39Pustule (HP:0200039)3.17845492
40Abnormality of eosinophils (HP:0001879)3.10718718
41Abnormality of cells of the erythroid lineage (HP:0012130)3.08296603
42Cellular immunodeficiency (HP:0005374)3.07483350
43Granulocytopenia (HP:0001913)3.03894333
44IgM deficiency (HP:0002850)3.03148085
45Gastrointestinal infarctions (HP:0005244)2.98834941
46Leukocytosis (HP:0001974)2.94630477
47Ependymoma (HP:0002888)2.94515131
48Recurrent skin infections (HP:0001581)2.93250691
49Abnormality of the prostate (HP:0008775)2.93214929
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.91809252
51Bronchitis (HP:0012387)2.90948166
52Urticaria (HP:0001025)2.86909485
53Inflammation of the large intestine (HP:0002037)2.84211129
54Prominent metopic ridge (HP:0005487)2.81689958
55Increased IgE level (HP:0003212)2.80018670
56Abnormality of endocrine pancreas physiology (HP:0012093)2.79049103
57Abnormality of the pancreatic islet cells (HP:0006476)2.79049103
58Eosinophilia (HP:0001880)2.78943126
59Colitis (HP:0002583)2.76764708
60Keratoconjunctivitis sicca (HP:0001097)2.74643034
61Asplenia (HP:0001746)2.74457641
62Premature loss of primary teeth (HP:0006323)2.72370720
63Abnormal number of erythroid precursors (HP:0012131)2.70647241
64Basal cell carcinoma (HP:0002671)2.67505113
65Premature graying of hair (HP:0002216)2.67310275
66Hyperinsulinemic hypoglycemia (HP:0000825)2.64783489
67Keratoconjunctivitis (HP:0001096)2.64278866
68Abnormality of the anterior horn cell (HP:0006802)2.64011827
69Degeneration of anterior horn cells (HP:0002398)2.64011827
70Orthostatic hypotension (HP:0001278)2.63266530
71Verrucae (HP:0200043)2.62310378
72Papilloma (HP:0012740)2.62310378
7311 pairs of ribs (HP:0000878)2.61155164
74Recurrent bronchitis (HP:0002837)2.59236503
75Carpal bone hypoplasia (HP:0001498)2.57285212
76Intestinal atresia (HP:0011100)2.56252254
77Hemoptysis (HP:0002105)2.54741403
78Overlapping toe (HP:0001845)2.47810378
79Supernumerary spleens (HP:0009799)2.47660243
80Aplasia/Hypoplasia of the spleen (HP:0010451)2.47534338
81Cellulitis (HP:0100658)2.46666598
82Missing ribs (HP:0000921)2.45364347
83Macrocytic anemia (HP:0001972)2.45308420
84Medulloblastoma (HP:0002885)2.43499455
85Chest pain (HP:0100749)2.42816276
86Stomach cancer (HP:0012126)2.42719462
87Skin rash (HP:0000988)2.42160603
88Abnormality of the metopic suture (HP:0005556)2.37751474
89Absent thumb (HP:0009777)2.37747051
90Aplastic anemia (HP:0001915)2.37477247
91Osteomyelitis (HP:0002754)2.37391806
92Autoimmune thrombocytopenia (HP:0001973)2.37094629
93Pallor (HP:0000980)2.29182689
94Lymphoma (HP:0002665)2.28928821
95Emphysema (HP:0002097)2.28291499
96Hypergammaglobulinemia (HP:0010702)2.28101062
97Optic nerve coloboma (HP:0000588)2.28099672
98Restrictive lung disease (HP:0002091)2.27394442
99Abnormality of the pleura (HP:0002103)2.24876534
100Oral leukoplakia (HP:0002745)2.24395508
101Atrophy/Degeneration involving motor neurons (HP:0007373)2.24164520
102Prostate neoplasm (HP:0100787)2.22452143
103Cerebral hypomyelination (HP:0006808)2.20565519
104Dysautonomia (HP:0002459)2.19542254
105Hypochromic anemia (HP:0001931)2.19120368
106Hypertensive crisis (HP:0100735)2.17666931
107Bronchiectasis (HP:0002110)2.16852965
108Arterial thrombosis (HP:0004420)2.16468320
109Acute hepatic failure (HP:0006554)2.16287494
110Gangrene (HP:0100758)2.15826456
111Anorexia (HP:0002039)2.15712184
112Agnosia (HP:0010524)2.15098069
113Abnormality of cells of the lymphoid lineage (HP:0012140)2.14026877
114Lymphopenia (HP:0001888)2.12339753
115Abnormal number of incisors (HP:0011064)2.10267289
116Neoplasm of the pancreas (HP:0002894)2.08981503
117Recurrent lower respiratory tract infections (HP:0002783)2.08158810
118Pulmonary fibrosis (HP:0002206)2.08015046
119Joint swelling (HP:0001386)2.07741735
120Neutropenia (HP:0001875)2.07605969
121Abnormality of abdominal situs (HP:0011620)2.07108636
122Abdominal situs inversus (HP:0003363)2.07108636
123Abnormality of calcium-phosphate metabolism (HP:0100530)2.06626132
124Thyroiditis (HP:0100646)2.05470847
125Recurrent pneumonia (HP:0006532)2.05296996
126Deep palmar crease (HP:0006191)2.03970100
127Pulmonary embolism (HP:0002204)2.03730126
128Abnormality of T cell physiology (HP:0011840)2.03668496
129Sepsis (HP:0100806)2.03064544
130Abnormality of male internal genitalia (HP:0000022)2.01570216
131Pancreatic islet-cell hyperplasia (HP:0004510)1.99287367
132Microvesicular hepatic steatosis (HP:0001414)1.99259118
133Rough bone trabeculation (HP:0100670)1.99144796
134Leukopenia (HP:0001882)1.98743206
135Hypoglycemic seizures (HP:0002173)1.97267163
136Spontaneous hematomas (HP:0007420)1.96759903
137Cleft eyelid (HP:0000625)1.95890130
138Abnormal delayed hypersensitivity skin test (HP:0002963)1.94015865
139Protruding tongue (HP:0010808)1.93962139
140Selective tooth agenesis (HP:0001592)1.93908409
141B lymphocytopenia (HP:0010976)1.91316488
142Abnormality of B cell number (HP:0010975)1.91316488
143Chronic sinusitis (HP:0011109)1.91008571
144Petechiae (HP:0000967)1.90196061
145Hypoplasia of the thymus (HP:0000778)1.89368232
146Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86680497
147Recurrent gram-negative bacterial infections (HP:0005420)1.86194627
148IgG deficiency (HP:0004315)1.85969069
149Trismus (HP:0000211)1.85682762
150Recurrent otitis media (HP:0000403)1.85293518
151Long palpebral fissure (HP:0000637)1.85288017
152Microretrognathia (HP:0000308)1.83947743
153Unsteady gait (HP:0002317)1.83896133
154Long eyelashes (HP:0000527)1.83465546
155Amaurosis fugax (HP:0100576)1.82774501
156Chronic otitis media (HP:0000389)1.82120583
157Rib fusion (HP:0000902)1.79465420
158Gastrointestinal inflammation (HP:0004386)1.78417130
159Anal stenosis (HP:0002025)1.76221066
160Emotional lability (HP:0000712)1.76007674
161Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74927643
162Limb hypertonia (HP:0002509)1.74421888
163Severe combined immunodeficiency (HP:0004430)1.72502829
164Symptomatic seizures (HP:0011145)1.72412432
165Rhabdomyosarcoma (HP:0002859)1.72204204
166Menstrual irregularities (HP:0000858)1.71455758
167Patellar aplasia (HP:0006443)1.70097746
168Abnormality of the labia minora (HP:0012880)1.68638299
169Progressive muscle weakness (HP:0003323)1.68569338
170Acute lymphatic leukemia (HP:0006721)1.68423420
171Nasal polyposis (HP:0100582)1.68344720
172Intestinal fistula (HP:0100819)1.67057264
173Neoplasm of the oral cavity (HP:0100649)1.65952725
174Impaired smooth pursuit (HP:0007772)1.65782503
175Horseshoe kidney (HP:0000085)1.65679529
176Pelvic girdle muscle weakness (HP:0003749)1.65494998
177Thrombocytosis (HP:0001894)1.65118459
178Myelodysplasia (HP:0002863)1.65108325
179Poikiloderma (HP:0001029)1.63449405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK34.45096164
2BUB13.67715993
3PASK3.26632570
4MAP4K13.26511027
5TAOK33.24856825
6CDC73.19765826
7RIPK43.15123729
8MAPK152.94870142
9TSSK62.89181810
10MAP3K142.72907122
11IKBKE2.64382325
12PRPF4B2.64349925
13EIF2AK12.37106244
14GRK62.20934051
15FES2.16186452
16IRAK42.14781220
17TBK12.10301602
18TESK21.97416004
19WEE11.97158397
20SCYL21.91345374
21IKBKB1.86698193
22HIPK21.86288643
23EIF2AK31.81419136
24TXK1.76478632
25MAP3K91.73864487
26STK161.72495906
27JAK11.67213804
28MAP3K101.59303108
29ALK1.56859625
30DAPK11.53560493
31PNCK1.51329449
32FGFR41.50447302
33NLK1.48728680
34ITK1.43127728
35CSK1.39892297
36UHMK11.36334783
37MAP3K111.34074459
38BTK1.32356167
39SMG11.32086113
40BRD41.31565645
41SRPK11.31485773
42FLT31.30313627
43MST41.28295492
44CDK121.26160651
45HCK1.24334852
46EEF2K1.23250661
47NEK21.21886086
48KIT1.21249466
49MAP2K21.20816418
50MATK1.20155347
51CDK71.20057582
52MARK31.18198516
53JAK31.17344603
54BMPR21.15087349
55DYRK31.15029727
56KSR21.13705434
57STK101.12406953
58ADRBK21.11889369
59ZAP701.11597669
60MAP3K131.08886212
61RPS6KA41.07164270
62BCKDK1.06413251
63ATR1.04764052
64VRK11.02908204
65CSF1R1.02858831
66PRKCQ1.00990474
67PLK10.99201326
68PAK40.96789610
69CHEK10.96727023
70JAK20.96448981
71CDK40.91737544
72NME10.91274327
73PLK30.90430285
74MAP3K80.89790251
75MAP3K20.89165115
76TGFBR10.88101211
77ZAK0.81794216
78PLK40.81423702
79BRAF0.79629646
80TEC0.79119566
81SYK0.77637052
82VRK20.77386127
83CDK190.77303744
84AURKB0.77111172
85KDR0.76626581
86ARAF0.74095061
87FGFR30.73659697
88CDK20.73338303
89AURKA0.72472160
90CSNK2A20.70837805
91TAOK20.68980916
92RAF10.68631466
93MAPK110.68433850
94CHUK0.66311134
95EPHB10.65527785
96BRSK10.65250191
97MAPK70.62594318
98EPHA30.62003695
99FGFR10.61588797
100CHEK20.60383299
101MKNK10.58779596
102MAP3K120.58411795
103PIM10.58346414
104NME20.57909177
105ATM0.57394515
106RPS6KB20.56875588
107LCK0.56064259
108NUAK10.56026349
109PRKCI0.54136832
110MAP3K10.53365697
111FGR0.53049895
112LRRK20.50546884
113TYK20.50463422
114IRAK10.50115115
115IRAK30.47963285
116CSNK1E0.47863184
117RPS6KA50.47318052
118STK40.46434919
119PDK10.46393215
120ERN10.46207117
121ACVR1B0.45307471
122MAPK120.44458443
123TLK10.44147201
124MAPKAPK20.43925326
125LYN0.42175078
126PRKD20.42170622
127CLK10.42159864
128CSNK2A10.41300505
129BRSK20.40454095
130PTK20.40306471
131EIF2AK20.39209324
132SIK30.39119514
133SIK20.37692863
134NTRK30.37023854
135MAP2K30.36251650
136MAP2K60.35829596
137CDK10.35480304
138TAF10.35427854
139TNK20.35068484
140WNK40.34055885
141BLK0.33994875
142PRKDC0.33640297
143MTOR0.33599378
144CDK80.32990443
145MAPK30.30234357
146FYN0.28365405
147PRKCD0.26420698
148PRKCH0.24465749
149MAPK40.21249501
150RPS6KA10.20393174

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.68888094
2Spliceosome_Homo sapiens_hsa030403.38274517
3DNA replication_Homo sapiens_hsa030303.34861471
4Mismatch repair_Homo sapiens_hsa034303.34622608
5RNA polymerase_Homo sapiens_hsa030203.25593943
6Proteasome_Homo sapiens_hsa030503.12542551
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07256918
8RNA transport_Homo sapiens_hsa030132.75858223
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.65444160
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.65396333
11Protein export_Homo sapiens_hsa030602.57807966
12Base excision repair_Homo sapiens_hsa034102.21543286
13Leishmaniasis_Homo sapiens_hsa051402.17043747
14RNA degradation_Homo sapiens_hsa030182.09972172
15Viral myocarditis_Homo sapiens_hsa054162.09531389
16Type I diabetes mellitus_Homo sapiens_hsa049402.05471219
17Pyrimidine metabolism_Homo sapiens_hsa002402.03789480
18Nucleotide excision repair_Homo sapiens_hsa034201.90161453
19Homologous recombination_Homo sapiens_hsa034401.80925357
20mRNA surveillance pathway_Homo sapiens_hsa030151.78758649
21One carbon pool by folate_Homo sapiens_hsa006701.77779171
22Primary immunodeficiency_Homo sapiens_hsa053401.73686014
23Osteoclast differentiation_Homo sapiens_hsa043801.62119986
24Staphylococcus aureus infection_Homo sapiens_hsa051501.58210609
25Antigen processing and presentation_Homo sapiens_hsa046121.57304226
26Cell cycle_Homo sapiens_hsa041101.54448995
27Influenza A_Homo sapiens_hsa051641.48824328
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46177522
29Rheumatoid arthritis_Homo sapiens_hsa053231.40518461
30Non-homologous end-joining_Homo sapiens_hsa034501.34595838
31Basal transcription factors_Homo sapiens_hsa030221.32786914
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26678827
33Epstein-Barr virus infection_Homo sapiens_hsa051691.26237727
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16811691
35Systemic lupus erythematosus_Homo sapiens_hsa053221.16338131
36Allograft rejection_Homo sapiens_hsa053301.12384365
37Tuberculosis_Homo sapiens_hsa051521.12202759
38Toxoplasmosis_Homo sapiens_hsa051451.10112286
39T cell receptor signaling pathway_Homo sapiens_hsa046601.09159826
40Chemokine signaling pathway_Homo sapiens_hsa040621.08671019
41TNF signaling pathway_Homo sapiens_hsa046681.07437874
42Purine metabolism_Homo sapiens_hsa002301.06351067
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.01291859
44Oocyte meiosis_Homo sapiens_hsa041140.96446234
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95267899
46Fanconi anemia pathway_Homo sapiens_hsa034600.93811160
47Thyroid cancer_Homo sapiens_hsa052160.93406527
48Insulin secretion_Homo sapiens_hsa049110.91558213
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90578149
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87735422
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85760594
52Graft-versus-host disease_Homo sapiens_hsa053320.85654539
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84706597
54Folate biosynthesis_Homo sapiens_hsa007900.84216474
55Herpes simplex infection_Homo sapiens_hsa051680.82520918
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82254553
57Hepatitis C_Homo sapiens_hsa051600.80581078
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79833796
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77743312
60Malaria_Homo sapiens_hsa051440.76847134
61Asthma_Homo sapiens_hsa053100.76371303
62p53 signaling pathway_Homo sapiens_hsa041150.74490342
63Viral carcinogenesis_Homo sapiens_hsa052030.71257596
64Vibrio cholerae infection_Homo sapiens_hsa051100.68881641
65HTLV-I infection_Homo sapiens_hsa051660.68657180
66Glucagon signaling pathway_Homo sapiens_hsa049220.68458928
67Long-term potentiation_Homo sapiens_hsa047200.66978726
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65792300
69Measles_Homo sapiens_hsa051620.65157902
70Non-small cell lung cancer_Homo sapiens_hsa052230.64988298
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.61504989
72Biosynthesis of amino acids_Homo sapiens_hsa012300.59800726
73Legionellosis_Homo sapiens_hsa051340.59138381
74Autoimmune thyroid disease_Homo sapiens_hsa053200.57110362
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56880418
76Amphetamine addiction_Homo sapiens_hsa050310.56781515
77B cell receptor signaling pathway_Homo sapiens_hsa046620.56557983
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.55666357
79Selenocompound metabolism_Homo sapiens_hsa004500.55643214
80N-Glycan biosynthesis_Homo sapiens_hsa005100.54796205
81African trypanosomiasis_Homo sapiens_hsa051430.54058776
82Colorectal cancer_Homo sapiens_hsa052100.53717056
83Huntingtons disease_Homo sapiens_hsa050160.52447967
84Shigellosis_Homo sapiens_hsa051310.50547374
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48564167
86Sulfur relay system_Homo sapiens_hsa041220.45245556
87Type II diabetes mellitus_Homo sapiens_hsa049300.43780280
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43587050
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.42619107
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.41845373
91Cocaine addiction_Homo sapiens_hsa050300.41329329
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.40298139
93HIF-1 signaling pathway_Homo sapiens_hsa040660.40235878
94Apoptosis_Homo sapiens_hsa042100.39476995
95mTOR signaling pathway_Homo sapiens_hsa041500.38331155
96Parkinsons disease_Homo sapiens_hsa050120.38326489
97Dopaminergic synapse_Homo sapiens_hsa047280.37358177
98Hepatitis B_Homo sapiens_hsa051610.37020497
99Chronic myeloid leukemia_Homo sapiens_hsa052200.36559312
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36519381
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35827176
102Wnt signaling pathway_Homo sapiens_hsa043100.34947845
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.34402850
104Alcoholism_Homo sapiens_hsa050340.34335825
105Pertussis_Homo sapiens_hsa051330.33505779
106Pancreatic cancer_Homo sapiens_hsa052120.33315639
107Fructose and mannose metabolism_Homo sapiens_hsa000510.33292606
108* Acute myeloid leukemia_Homo sapiens_hsa052210.33121397
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31508437
110Circadian rhythm_Homo sapiens_hsa047100.31274033
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.29997827
112Prion diseases_Homo sapiens_hsa050200.29773127
113Prolactin signaling pathway_Homo sapiens_hsa049170.29404789
114Notch signaling pathway_Homo sapiens_hsa043300.28867142
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28841729
116Estrogen signaling pathway_Homo sapiens_hsa049150.28603813
117Synaptic vesicle cycle_Homo sapiens_hsa047210.28316521
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26443122
119Galactose metabolism_Homo sapiens_hsa000520.25705559
120Oxidative phosphorylation_Homo sapiens_hsa001900.24154601
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23111149
122Hematopoietic cell lineage_Homo sapiens_hsa046400.22314587
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21926524
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.21542749
125Phagosome_Homo sapiens_hsa041450.21231736
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20123022
127VEGF signaling pathway_Homo sapiens_hsa043700.16785201
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16696054
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16424621
130Melanogenesis_Homo sapiens_hsa049160.15952976
131Platelet activation_Homo sapiens_hsa046110.15828401
132Other glycan degradation_Homo sapiens_hsa005110.15345351
133Salmonella infection_Homo sapiens_hsa051320.13357869
134Prostate cancer_Homo sapiens_hsa052150.12973612
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11490465
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.10051934
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.09801669
138MAPK signaling pathway_Homo sapiens_hsa040100.09232019
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.08816974
140FoxO signaling pathway_Homo sapiens_hsa040680.08083179

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