PIK3CB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)5.11194276
2positive regulation by symbiont of host defense response (GO:0052509)4.69150013
3modulation by symbiont of host defense response (GO:0052031)4.69150013
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.69150013
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.69150013
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.69150013
7modulation by symbiont of host immune response (GO:0052553)4.69150013
8iron ion import (GO:0097286)4.30566371
9regulation of cholesterol storage (GO:0010885)3.80498499
10negative regulation of erythrocyte differentiation (GO:0045647)3.77213021
11cellular response to thyroid hormone stimulus (GO:0097067)3.69124454
12response to peptidoglycan (GO:0032494)3.59429254
13macrophage activation involved in immune response (GO:0002281)3.56174524
14positive regulation of cellular amide metabolic process (GO:0034250)3.51271497
15cell adhesion mediated by integrin (GO:0033627)3.40369941
16hepatocyte apoptotic process (GO:0097284)3.37936033
17protein localization to endosome (GO:0036010)3.37252660
18negative regulation of lipid storage (GO:0010888)3.31132485
19definitive hemopoiesis (GO:0060216)3.30520279
20positive regulation of gamma-delta T cell activation (GO:0046645)3.28444956
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.25767085
22positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.25608991
23regulation of integrin activation (GO:0033623)3.22902009
24response to thyroid hormone (GO:0097066)3.21748609
25regulation of interferon-beta biosynthetic process (GO:0045357)3.20856746
26NLS-bearing protein import into nucleus (GO:0006607)3.19627209
27cellular extravasation (GO:0045123)3.19505615
28apoptotic cell clearance (GO:0043277)3.19256216
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.19186351
30response to host immune response (GO:0052572)3.19186351
31neutrophil activation involved in immune response (GO:0002283)3.19170819
32natural killer cell mediated cytotoxicity (GO:0042267)3.17482846
33natural killer cell mediated immunity (GO:0002228)3.17482846
34regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.17189981
35positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.09564409
36positive regulation of p38MAPK cascade (GO:1900745)3.05735548
37thrombin receptor signaling pathway (GO:0070493)3.04459906
38pore complex assembly (GO:0046931)3.02078896
39glycosphingolipid catabolic process (GO:0046479)3.00686761
40positive regulation of interferon-alpha production (GO:0032727)3.00386027
41plasma lipoprotein particle clearance (GO:0034381)2.97318057
42hydrogen peroxide biosynthetic process (GO:0050665)2.96545100
43regulation of platelet aggregation (GO:0090330)2.96127395
44oligosaccharide catabolic process (GO:0009313)2.94326543
45macroautophagy (GO:0016236)2.92813785
46negative regulation of protein localization to plasma membrane (GO:1903077)2.92787129
47wound healing, spreading of epidermal cells (GO:0035313)2.92680325
48phospholipid homeostasis (GO:0055091)2.91342470
49response to muramyl dipeptide (GO:0032495)2.91030922
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.84879972
51response to host (GO:0075136)2.84879972
52response to host defenses (GO:0052200)2.84879972
53regulation of interferon-alpha production (GO:0032647)2.84685699
54negative regulation of dendrite morphogenesis (GO:0050774)2.81779487
55negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.79728491
56negative regulation of cell killing (GO:0031342)2.79728491
57Rap protein signal transduction (GO:0032486)2.79059373
58I-kappaB phosphorylation (GO:0007252)2.76691475
59regulation of membrane protein ectodomain proteolysis (GO:0051043)2.76600647
60negative regulation of interleukin-12 production (GO:0032695)2.75289035
61regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.74952101
62glycolipid catabolic process (GO:0019377)2.71321846
63positive regulation of lipid storage (GO:0010884)2.66974607
64positive regulation of interferon-beta production (GO:0032728)2.65233523
65regulation of platelet activation (GO:0010543)2.64761209
66regulation of sequestering of triglyceride (GO:0010889)2.64053644
67respiratory burst (GO:0045730)2.63552082
68alpha-linolenic acid metabolic process (GO:0036109)2.63195633
69regulation of macrophage chemotaxis (GO:0010758)2.62579023
70positive regulation of leukocyte degranulation (GO:0043302)2.62488417
71megakaryocyte development (GO:0035855)2.62283511
72regulation of protein polyubiquitination (GO:1902914)2.61393988
73positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.61240492
74negative regulation of interleukin-17 production (GO:0032700)2.60642484
75lipoprotein transport (GO:0042953)2.58973983
76negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.57807369
77growth hormone receptor signaling pathway (GO:0060396)2.57649977
78detection of molecule of bacterial origin (GO:0032490)2.57086151
79regulation of podosome assembly (GO:0071801)2.56946268
80positive regulation of receptor recycling (GO:0001921)2.56885427
81hypotonic response (GO:0006971)2.56494222
82cellular response to arsenic-containing substance (GO:0071243)2.56310963
83granulocyte activation (GO:0036230)2.55291262
84regulation of mast cell degranulation (GO:0043304)2.54676892
85pinocytosis (GO:0006907)2.53293576
86regulation of gamma-delta T cell activation (GO:0046643)2.53196068
87interferon-gamma secretion (GO:0072643)2.53111358
88regulation of T-helper 2 cell differentiation (GO:0045628)2.52781375
89cellular response to ethanol (GO:0071361)2.52529814
90regulation of leukocyte degranulation (GO:0043300)2.52135742
91hemidesmosome assembly (GO:0031581)2.49526640
92myeloid cell activation involved in immune response (GO:0002275)2.48218753
93positive regulation of regulated secretory pathway (GO:1903307)2.47653234
94reactive oxygen species biosynthetic process (GO:1903409)2.47586566
95JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.47573861
96lipopolysaccharide-mediated signaling pathway (GO:0031663)2.47238973
97immunoglobulin mediated immune response (GO:0016064)2.47150283
98regulation of regulated secretory pathway (GO:1903305)2.47123360
99cell-substrate junction assembly (GO:0007044)2.46900921
100nuclear pore complex assembly (GO:0051292)2.46783630
101regulation of cholesterol homeostasis (GO:2000188)2.45773759
102regulation of mononuclear cell migration (GO:0071675)2.44301579
103regulation of early endosome to late endosome transport (GO:2000641)2.43037743
104embryonic process involved in female pregnancy (GO:0060136)2.42163213
105regulation of translational termination (GO:0006449)2.41848320
106clathrin coat assembly (GO:0048268)2.40415493
107import into cell (GO:0098657)2.40194038
108regulation of lipid storage (GO:0010883)2.39696624
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.39644972
110regulation of myeloid leukocyte mediated immunity (GO:0002886)2.38609251
111mannose metabolic process (GO:0006013)2.38171101
112nerve growth factor signaling pathway (GO:0038180)2.37440593
113neutrophil mediated immunity (GO:0002446)2.36839123
114regulation of mast cell activation involved in immune response (GO:0033006)2.36455200
115positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.34964651
116positive regulation of toll-like receptor signaling pathway (GO:0034123)2.34784392
117negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.34038476
118positive regulation of sterol transport (GO:0032373)2.33538197
119positive regulation of cholesterol transport (GO:0032376)2.33538197
120positive regulation of heat generation (GO:0031652)2.33020775
121microglial cell activation (GO:0001774)2.32136451
122negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.31825132
123L-alpha-amino acid transmembrane transport (GO:1902475)2.31670113
124positive regulation of bone resorption (GO:0045780)2.31307540
125positive regulation of bone remodeling (GO:0046852)2.31307540
126regulation of gamma-delta T cell differentiation (GO:0045586)2.30925894
127regulation of nucleobase-containing compound transport (GO:0032239)2.30782245
128stress fiber assembly (GO:0043149)2.30731748
129peptide catabolic process (GO:0043171)2.30586107
130negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.30347957
131detection of other organism (GO:0098543)2.30075398
132neutrophil activation (GO:0042119)2.29899555
133urea cycle (GO:0000050)2.29694375
134urea metabolic process (GO:0019627)2.29694375
135positive regulation of mast cell activation (GO:0033005)2.29146918
136positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.28936298
137cytokine secretion (GO:0050663)2.27869455
138cortical actin cytoskeleton organization (GO:0030866)2.27512198
139macrophage activation (GO:0042116)2.27500649
140sphingosine metabolic process (GO:0006670)2.27355038
141germinal center formation (GO:0002467)2.27021879
142establishment of endothelial barrier (GO:0061028)2.26179470
143dicarboxylic acid biosynthetic process (GO:0043650)2.25436120
144modification by symbiont of host morphology or physiology (GO:0044003)2.25052690
145positive regulation of SMAD protein import into nucleus (GO:0060391)2.24802753
146positive regulation of Cdc42 GTPase activity (GO:0043089)2.23820960
147adenosine receptor signaling pathway (GO:0001973)2.23194437
148positive regulation of lipid catabolic process (GO:0050996)2.23154992
149leukocyte mediated cytotoxicity (GO:0001909)2.22996473
150regulation of interferon-beta production (GO:0032648)2.22625163
151positive regulation of phagocytosis (GO:0050766)2.22426124
152osteoclast differentiation (GO:0030316)2.21001960
153nuclear pore organization (GO:0006999)2.20662991
154* platelet aggregation (GO:0070527)2.20367587
155ceramide catabolic process (GO:0046514)2.20352630
156negative regulation of toll-like receptor signaling pathway (GO:0034122)2.20276863
157regulation of hippo signaling (GO:0035330)2.19786117
158myeloid cell development (GO:0061515)2.19029140
159regulation of RNA export from nucleus (GO:0046831)2.16241699
160regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.15934537
161leukocyte degranulation (GO:0043299)2.15022359
162negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.14993080
163vesicle coating (GO:0006901)2.13908813
164early endosome to late endosome transport (GO:0045022)2.13373499
165linoleic acid metabolic process (GO:0043651)2.11398353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.17074285
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.83463691
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.76671777
4GATA1_22025678_ChIP-Seq_K562_Human3.41713091
5* SCL_19346495_ChIP-Seq_HPC-7_Human3.21463784
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.21421217
7* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.09945107
8* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71975464
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69686878
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.64808894
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.60353624
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.57471744
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55208312
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53389797
15E2F7_22180533_ChIP-Seq_HELA_Human2.46045918
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.29872598
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.25714310
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.24846055
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.19333902
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.15702873
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.11717839
22ESR1_20079471_ChIP-ChIP_T-47D_Human2.11531479
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06393134
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03264502
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00642297
26ZNF263_19887448_ChIP-Seq_K562_Human1.98495136
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.94173611
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88838467
29CLOCK_20551151_ChIP-Seq_293T_Human1.87905349
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.86324379
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.80588509
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78706932
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.75097188
34* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.73441697
35* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70377452
36GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.70275489
37PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.68755546
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.62867553
39* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59880221
40* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57651282
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57317539
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54173671
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54079124
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52303956
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51522095
46SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51522095
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51353029
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50923017
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49493178
50ATF3_27146783_Chip-Seq_COLON_Human1.49279894
51* GATA1_19941827_ChIP-Seq_MEL_Mouse1.49061588
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46565227
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.46050460
54SPI1_23547873_ChIP-Seq_NB4_Human1.45211328
55TCF7_22412390_ChIP-Seq_EML_Mouse1.44832793
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44281428
57* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.43677073
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43517849
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42577644
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42240364
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42210807
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.41690035
63* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41070376
64FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.40055591
65* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37195034
66KDM2B_26808549_Chip-Seq_DND41_Human1.36666544
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36395165
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36218063
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35787475
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33648412
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33093120
72* SPI1_23127762_ChIP-Seq_K562_Human1.31087462
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.31002436
74* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30166402
75GATA6_25053715_ChIP-Seq_YYC3_Human1.26371978
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26178017
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26178017
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26178017
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25726793
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25068491
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24646704
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24538897
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24233860
84RACK7_27058665_Chip-Seq_MCF-7_Human1.23298360
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.20816805
86GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20641768
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19817533
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19545406
89GATA1_19941826_ChIP-Seq_K562_Human1.18821173
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15884555
91* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.15043192
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14851295
93MYB_26560356_Chip-Seq_TH2_Human1.13723660
94PU_27001747_Chip-Seq_BMDM_Mouse1.13210368
95AR_21909140_ChIP-Seq_LNCAP_Human1.12727068
96VDR_24787735_ChIP-Seq_THP-1_Human1.11897327
97VDR_21846776_ChIP-Seq_THP-1_Human1.11434802
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.10829092
99MYC_22102868_ChIP-Seq_BL_Human1.09207450
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07899839
101LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07622054
102MAF_26560356_Chip-Seq_TH1_Human1.06108336
103RUNX_20019798_ChIP-Seq_JUKART_Human1.06080472
104* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06057930
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05337546
106STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05291247
107SOX2_20726797_ChIP-Seq_SW620_Human1.05269843
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03604090
109CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03511816
110RUNX1_22412390_ChIP-Seq_EML_Mouse1.03256631
111ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02813893
112FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01589266
113SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01433994
114TFEB_21752829_ChIP-Seq_HELA_Human1.01351593
115GATA2_19941826_ChIP-Seq_K562_Human1.01233034
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01181096
117NCOR1_26117541_ChIP-Seq_K562_Human1.00192853
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00163317
119* FOXA2_19822575_ChIP-Seq_HepG2_Human0.99694832
120ETS1_22383799_ChIP-Seq_G1ME_Mouse0.98263385
121* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97991502
122GATA4_25053715_ChIP-Seq_YYC3_Human0.97005505
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96985160
124KDM2B_26808549_Chip-Seq_K562_Human0.96167711
125CHD1_26751641_Chip-Seq_LNCaP_Human0.95415654
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94856116
127TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94463521
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94017121
129* VDR_24763502_ChIP-Seq_THP-1_Human0.93584817
130MYB_26560356_Chip-Seq_TH1_Human0.92839469
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92575863
132* RUNX1_27514584_Chip-Seq_MCF-7_Human0.91962092
133KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89641685
134UBF1/2_26484160_Chip-Seq_HMECs_Human0.89296535
135CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89014824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.70232130
2MP0003705_abnormal_hypodermis_morpholog3.59898373
3MP0000569_abnormal_digit_pigmentation2.91336296
4MP0005076_abnormal_cell_differentiation2.89105011
5MP0005058_abnormal_lysosome_morphology2.74506658
6MP0003566_abnormal_cell_adhesion2.72537195
7MP0010352_gastrointestinal_tract_polyps2.71448352
8MP0005451_abnormal_body_composition2.67168908
9MP0010234_abnormal_vibrissa_follicle2.59743538
10MP0003191_abnormal_cellular_cholesterol2.57863620
11MP0003436_decreased_susceptibility_to2.46886293
12MP0009840_abnormal_foam_cell2.28936650
13MP0003172_abnormal_lysosome_physiology2.28151454
14MP0008057_abnormal_DNA_replication2.22604099
15MP0004510_myositis2.20041131
16MP0003300_gastrointestinal_ulcer2.18295739
17MP0009278_abnormal_bone_marrow2.16289604
18MP0004185_abnormal_adipocyte_glucose2.13742433
19MP0008004_abnormal_stomach_pH2.10028981
20MP0010307_abnormal_tumor_latency2.09845008
21MP0005360_urolithiasis2.05129579
22MP0004947_skin_inflammation1.99448771
23MP0003453_abnormal_keratinocyte_physiol1.99330949
24MP0003724_increased_susceptibility_to1.97527857
25MP0002796_impaired_skin_barrier1.92072034
26MP0002254_reproductive_system_inflammat1.83060134
27MP0003183_abnormal_peptide_metabolism1.79967612
28MP0002419_abnormal_innate_immunity1.78619919
29MP0005409_darkened_coat_color1.75096646
30MP0002877_abnormal_melanocyte_morpholog1.69427449
31MP0006082_CNS_inflammation1.68967179
32MP0004808_abnormal_hematopoietic_stem1.67508854
33MP0001545_abnormal_hematopoietic_system1.61536201
34MP0005397_hematopoietic_system_phenotyp1.61536201
35MP0003828_pulmonary_edema1.60489864
36MP0002148_abnormal_hypersensitivity_rea1.60371962
37MP0003091_abnormal_cell_migration1.56243426
38* MP0003448_altered_tumor_morphology1.55478272
39MP0000604_amyloidosis1.52769253
40MP0008260_abnormal_autophagy1.49221121
41MP0002139_abnormal_hepatobiliary_system1.48566553
42MP0010329_abnormal_lipoprotein_level1.46070633
43MP0000015_abnormal_ear_pigmentation1.45431656
44MP0003656_abnormal_erythrocyte_physiolo1.45128354
45* MP0005464_abnormal_platelet_physiology1.44900229
46MP0003075_altered_response_to1.44808522
47MP0005023_abnormal_wound_healing1.38550381
48MP0001835_abnormal_antigen_presentation1.38359935
49MP0005167_abnormal_blood-brain_barrier1.37555529
50MP0002009_preneoplasia1.33880826
51MP0000609_abnormal_liver_physiology1.31497121
52MP0004130_abnormal_muscle_cell1.29096742
53MP0005666_abnormal_adipose_tissue1.28425250
54MP0002396_abnormal_hematopoietic_system1.26843710
55MP0004147_increased_porphyrin_level1.25826591
56MP0000858_altered_metastatic_potential1.25384072
57MP0001533_abnormal_skeleton_physiology1.24141764
58MP0001851_eye_inflammation1.21419860
59MP0002006_tumorigenesis1.21105454
60MP0002138_abnormal_hepatobiliary_system1.20893518
61MP0005025_abnormal_response_to1.18473171
62MP0005365_abnormal_bile_salt1.17562742
63MP0003950_abnormal_plasma_membrane1.16946055
64MP0005085_abnormal_gallbladder_physiolo1.16791801
65MP0001853_heart_inflammation1.16712366
66MP0002166_altered_tumor_susceptibility1.16358031
67MP0008875_abnormal_xenobiotic_pharmacok1.14564393
68MP0001216_abnormal_epidermal_layer1.14415514
69MP0010155_abnormal_intestine_physiology1.14399836
70MP0000465_gastrointestinal_hemorrhage1.13767262
71MP0004233_abnormal_muscle_weight1.12860349
72MP0003806_abnormal_nucleotide_metabolis1.12216863
73MP0003690_abnormal_glial_cell1.10327538
74MP0000343_altered_response_to1.10315741
75MP0004264_abnormal_extraembryonic_tissu1.10171430
76MP0005408_hypopigmentation1.09131251
77MP0009764_decreased_sensitivity_to1.09041191
78MP0005257_abnormal_intraocular_pressure1.08201241
79MP0002452_abnormal_antigen_presenting1.07805051
80MP0009785_altered_susceptibility_to1.06611845
81MP0005501_abnormal_skin_physiology1.06033288
82MP0005000_abnormal_immune_tolerance1.05634899
83MP0004484_altered_response_of1.02766410
84MP0005083_abnormal_biliary_tract1.01029943
85MP0002398_abnormal_bone_marrow1.00330146
86MP0001881_abnormal_mammary_gland1.00321475
87MP0000383_abnormal_hair_follicle1.00071911
88MP0001845_abnormal_inflammatory_respons0.98961889
89MP0002405_respiratory_system_inflammati0.96002053
90MP0002086_abnormal_extraembryonic_tissu0.95468451
91MP0000627_abnormal_mammary_gland0.94531711
92MP0000371_diluted_coat_color0.93774487
93MP0003252_abnormal_bile_duct0.93587429
94MP0005310_abnormal_salivary_gland0.93023446
95MP0008469_abnormal_protein_level0.92276933
96MP0009697_abnormal_copulation0.92119535
97MP0005670_abnormal_white_adipose0.90541731
98MP0005166_decreased_susceptibility_to0.89018277
99MP0001915_intracranial_hemorrhage0.88930387
100MP0004381_abnormal_hair_follicle0.88888809
101MP0002723_abnormal_immune_serum0.87428521
102MP0001790_abnormal_immune_system0.87354354
103MP0005387_immune_system_phenotype0.87354354
104MP0005319_abnormal_enzyme/_coenzyme0.87147942
105MP0003221_abnormal_cardiomyocyte_apopto0.87041513
106MP0000685_abnormal_immune_system0.85771210
107MP0005375_adipose_tissue_phenotype0.85239187
108* MP0005621_abnormal_cell_physiology0.85105320
109MP0002060_abnormal_skin_morphology0.84381702
110MP0002420_abnormal_adaptive_immunity0.83825105
111MP0005164_abnormal_response_to0.83242539
112MP0009763_increased_sensitivity_to0.82010329
113MP0004858_abnormal_nervous_system0.81695288
114MP0005165_increased_susceptibility_to0.81259095
115MP0005174_abnormal_tail_pigmentation0.80673255
116MP0009115_abnormal_fat_cell0.80663764
117* MP0002118_abnormal_lipid_homeostasis0.80282175
118MP0001849_ear_inflammation0.79961075
119MP0001800_abnormal_humoral_immune0.79092165
120MP0000920_abnormal_myelination0.79063761
121MP0010678_abnormal_skin_adnexa0.79061419
122MP0005647_abnormal_sex_gland0.78618693
123MP0000598_abnormal_liver_morphology0.77451908
124MP0002332_abnormal_exercise_endurance0.76669995
125MP0001191_abnormal_skin_condition0.76146243
126MP0001819_abnormal_immune_cell0.76019028
127MP0002971_abnormal_brown_adipose0.75923733
128MP0002998_abnormal_bone_remodeling0.74147016
129MP0002429_abnormal_blood_cell0.74139297
130MP0002088_abnormal_embryonic_growth/wei0.73928472
131MP0004019_abnormal_vitamin_homeostasis0.73912685
132MP0000689_abnormal_spleen_morphology0.73806536
133* MP0005384_cellular_phenotype0.73488987
134MP0000716_abnormal_immune_system0.73233533
135MP0004883_abnormal_blood_vessel0.72741079
136MP0003984_embryonic_growth_retardation0.72452752

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)4.53576282
2Eczematoid dermatitis (HP:0000976)4.49295529
3Prolonged bleeding time (HP:0003010)4.46823645
4Recurrent abscess formation (HP:0002722)4.27450080
5Recurrent bacterial skin infections (HP:0005406)4.13834065
6Petechiae (HP:0000967)3.79732565
7Myocardial infarction (HP:0001658)3.71073094
8Increased cerebral lipofuscin (HP:0011813)3.70022536
9Menorrhagia (HP:0000132)3.57152787
10Gingival bleeding (HP:0000225)3.40594015
11Abnormality of macrophages (HP:0004311)3.33824779
12Epistaxis (HP:0000421)3.29993447
13Axonal loss (HP:0003447)3.08232345
14Global brain atrophy (HP:0002283)3.03779793
15Purpura (HP:0000979)2.99690880
16Papillary thyroid carcinoma (HP:0002895)2.90429900
17Increased neuronal autofluorescent lipopigment (HP:0002074)2.85143661
18Autoimmune thrombocytopenia (HP:0001973)2.78961286
19Abnormal platelet function (HP:0011869)2.74655437
20Impaired platelet aggregation (HP:0003540)2.74655437
21Gingivitis (HP:0000230)2.72997893
22Thick nail (HP:0001805)2.70444246
23Acanthocytosis (HP:0001927)2.69309649
24Acute myeloid leukemia (HP:0004808)2.69129703
25Osteolytic defects of the hand bones (HP:0009699)2.68630323
26Osteolytic defects of the phalanges of the hand (HP:0009771)2.68630323
27Hematochezia (HP:0002573)2.66643539
28Disinhibition (HP:0000734)2.65945147
29Termporal pattern (HP:0011008)2.60334819
30Insidious onset (HP:0003587)2.60334819
31Dysmetric saccades (HP:0000641)2.59882219
32Systemic lupus erythematosus (HP:0002725)2.58566739
33Upper motor neuron abnormality (HP:0002127)2.51194325
34Curly hair (HP:0002212)2.49107215
35Mediastinal lymphadenopathy (HP:0100721)2.46902521
36Esophageal varix (HP:0002040)2.46368432
37Autoimmune hemolytic anemia (HP:0001890)2.46131769
38Vacuolated lymphocytes (HP:0001922)2.45527631
39Macroorchidism (HP:0000053)2.45153763
40Mucopolysacchariduria (HP:0008155)2.43723972
41Urinary glycosaminoglycan excretion (HP:0003541)2.43723972
42Spontaneous hematomas (HP:0007420)2.42639928
43Frequent falls (HP:0002359)2.41210620
44Poikilocytosis (HP:0004447)2.39612606
45Slow saccadic eye movements (HP:0000514)2.39510832
46Prostate neoplasm (HP:0100787)2.39433073
47Dysostosis multiplex (HP:0000943)2.38965648
48Xanthomatosis (HP:0000991)2.38710030
49Pustule (HP:0200039)2.35417390
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34851492
51Abnormality of polysaccharide metabolism (HP:0011012)2.34851492
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34851492
53Hand muscle atrophy (HP:0009130)2.32831860
54Ankyloglossia (HP:0010296)2.32262336
55Cerebral aneurysm (HP:0004944)2.31033588
56Tetraparesis (HP:0002273)2.28956482
57Abnormality of the common coagulation pathway (HP:0010990)2.28105659
58Amyloidosis (HP:0011034)2.27497188
59Abnormal large intestine physiology (HP:0012700)2.27365176
60Upper limb amyotrophy (HP:0009129)2.27345929
61Distal upper limb amyotrophy (HP:0007149)2.27345929
62Abnormality of proline metabolism (HP:0010907)2.27205683
63Hydroxyprolinuria (HP:0003080)2.27205683
64Abnormality of the Achilles tendon (HP:0005109)2.27171308
65Cerebral inclusion bodies (HP:0100314)2.25960342
66Increased mean platelet volume (HP:0011877)2.24783752
67Achilles tendon contracture (HP:0001771)2.23697067
68Deep venous thrombosis (HP:0002625)2.22640772
69Abnormality of glycolipid metabolism (HP:0010969)2.20027184
70Abnormality of liposaccharide metabolism (HP:0010968)2.20027184
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.20027184
72Bowel incontinence (HP:0002607)2.15655597
73Recurrent skin infections (HP:0001581)2.15299799
74Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.14698865
75Complement deficiency (HP:0004431)2.13813474
76Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08428063
77Cortical dysplasia (HP:0002539)2.06929614
78Nephritis (HP:0000123)2.05574860
79Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.04682834
80Urticaria (HP:0001025)2.04668848
81Recurrent fungal infections (HP:0002841)2.04495289
82Neurofibrillary tangles (HP:0002185)2.03823530
83Thyroid carcinoma (HP:0002890)2.02928484
84Epidermoid cyst (HP:0200040)2.02543707
85Abnormal platelet volume (HP:0011876)2.01798503
86Interstitial pulmonary disease (HP:0006530)2.01747126
87Abnormality of complement system (HP:0005339)2.01623169
88Increased CSF protein (HP:0002922)2.01412846
89Transitional cell carcinoma of the bladder (HP:0006740)2.01032238
90Conjunctival telangiectasia (HP:0000524)2.01013709
91Periodontitis (HP:0000704)2.01008813
92Peripheral demyelination (HP:0011096)2.00238178
93Subacute progressive viral hepatitis (HP:0006572)1.99290463
94Leiomyosarcoma (HP:0100243)1.97709758
95Uterine leiomyosarcoma (HP:0002891)1.97709758
96Obstructive lung disease (HP:0006536)1.97506133
97Chronic obstructive pulmonary disease (HP:0006510)1.97506133
98Bladder carcinoma (HP:0002862)1.96465073
99Bladder neoplasm (HP:0009725)1.96465073
100Right ventricular cardiomyopathy (HP:0011663)1.95892091
101Pathologic fracture (HP:0002756)1.95536504
102Stomatitis (HP:0010280)1.95018802
103Spastic tetraparesis (HP:0001285)1.94723636
104Abnormality of saccadic eye movements (HP:0000570)1.92576370
105Abnormality of glutamine family amino acid metabolism (HP:0010902)1.92145121
106Hemorrhage of the eye (HP:0011885)1.90615178
107Orchitis (HP:0100796)1.90476750
108Neuronal loss in central nervous system (HP:0002529)1.88938160
109Abnormality of the fingertips (HP:0001211)1.88016174
110Increased connective tissue (HP:0009025)1.87001686
111Spastic diplegia (HP:0001264)1.85231845
112Reticulocytosis (HP:0001923)1.85162982
113Glomerulonephritis (HP:0000099)1.84781454
114Alopecia of scalp (HP:0002293)1.81331301
115Abnormality of iron homeostasis (HP:0011031)1.80017516
116Deep philtrum (HP:0002002)1.79518519
117Abnormality of monocarboxylic acid metabolism (HP:0010996)1.78752473
118Increased serum ferritin (HP:0003281)1.78554211
119Biliary tract neoplasm (HP:0100574)1.77989729
120Bone pain (HP:0002653)1.77947688
121Ocular albinism (HP:0001107)1.77803317
122Urethral obstruction (HP:0000796)1.76533151
123Agnosia (HP:0010524)1.75958972
124Hypercholesterolemia (HP:0003124)1.75343312
125Hyperthyroidism (HP:0000836)1.75012691
126Amaurosis fugax (HP:0100576)1.74028014
127Decreased motor nerve conduction velocity (HP:0003431)1.73867549
128Autoamputation (HP:0001218)1.73516041
129Myositis (HP:0100614)1.72469712
130Cerebral hemorrhage (HP:0001342)1.72454200
131Bilateral sensorineural hearing impairment (HP:0008619)1.72278252
132Postural tremor (HP:0002174)1.70931524
133Sensorimotor neuropathy (HP:0007141)1.70132547
134Fatigue (HP:0012378)1.70010885
135Abnormal gallbladder physiology (HP:0012438)1.70007442
136Cholecystitis (HP:0001082)1.70007442
137Acanthosis nigricans (HP:0000956)1.69970329
138Abnormality of oral frenula (HP:0000190)1.69508009
139Polycythemia (HP:0001901)1.69181436
140Abnormality of transition element cation homeostasis (HP:0011030)1.69091633
141Coarse hair (HP:0002208)1.68829073
142Flat acetabular roof (HP:0003180)1.68826746
143Ulnar bowing (HP:0003031)1.67973945
144Viral hepatitis (HP:0006562)1.66202401
145Joint hemorrhage (HP:0005261)1.65696114
146Hypoalphalipoproteinemia (HP:0003233)1.64707341
147Malignant gastrointestinal tract tumors (HP:0006749)1.64341653
148Gastrointestinal carcinoma (HP:0002672)1.64341653
149Oligodontia (HP:0000677)1.63898680
150Dyschromatopsia (HP:0007641)1.63889938
151Turricephaly (HP:0000262)1.63469230
152Loss of speech (HP:0002371)1.63187209
153Hyporeflexia of lower limbs (HP:0002600)1.63115073
154Abnormality of the lumbar spine (HP:0100712)1.62070210
155Scanning speech (HP:0002168)1.62030542
156Spinal muscular atrophy (HP:0007269)1.62025943
157Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.61940505
158Ventricular fibrillation (HP:0001663)1.61384913
159Osteomyelitis (HP:0002754)1.60435771
160Resting tremor (HP:0002322)1.58581529
161Bundle branch block (HP:0011710)1.57694047
162Personality changes (HP:0000751)1.56477695
163Skin nodule (HP:0200036)1.56169750
164Arterial thrombosis (HP:0004420)1.55964146
165Paralysis (HP:0003470)1.55879121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.44548377
2RIPK43.07766473
3BMPR23.04949543
4MST42.96665412
5CAMK1D2.82542954
6TRIB32.53826438
7EIF2AK12.41673805
8MAP3K92.32334849
9EPHA22.22444730
10KSR22.02085100
11MAP3K142.01181298
12TTN1.92757582
13LATS11.88433377
14ERN11.86927007
15SCYL21.86833526
16CAMK1G1.85102937
17PKN21.84569249
18PRPF4B1.77394706
19LATS21.77319742
20STK101.76734401
21TBK11.65136104
22CDK61.63409939
23MAP3K11.61444286
24TYK21.61070581
25ALK1.58615259
26AKT31.56158226
27BMX1.55828264
28RIPK11.52602978
29STK31.51717552
30PTK61.49402204
31IRAK31.41428480
32MAP3K21.39286500
33MAP2K31.38098822
34CSK1.34974628
35FGR1.34168094
36MAP3K31.33686452
37IRAK21.32639559
38EEF2K1.28478791
39RPS6KA41.28128241
40ACVR1B1.26907698
41YES11.25972604
42SIK31.18421153
43MAP3K131.18012004
44SIK11.16716562
45JAK11.16437166
46BRSK21.15903067
47ZAP701.15573233
48PBK1.15090903
49EPHB11.13864837
50IRAK11.09204139
51ICK1.08629330
52PTK21.06949468
53TAOK11.03497010
54MTOR1.02920159
55NEK91.02547787
56STK381.01769442
57NEK11.00708197
58ABL20.99855576
59JAK20.97121197
60TAOK30.96553671
61DAPK20.96241837
62NEK60.96059735
63LRRK20.95878677
64MAP3K120.95232222
65PAK40.94493475
66MAP3K80.92643840
67PDK20.90780628
68TGFBR20.90415444
69IKBKB0.90150376
70EIF2AK30.90060707
71TEC0.89961207
72FRK0.89546690
73RAF10.88714898
74MAP3K50.88454373
75TAOK20.87709197
76EGFR0.86076104
77CAMKK10.84726214
78HCK0.83671797
79TRPM70.81376034
80CSF1R0.79813451
81MARK30.79433449
82RPS6KB20.79369101
83CHUK0.79276556
84MST1R0.79032845
85BTK0.76839165
86PNCK0.75758443
87ERBB40.75558009
88PIM10.75184142
89MAP3K60.73824751
90NEK20.73578696
91WNK10.70121811
92SYK0.70011271
93PDGFRB0.69739918
94CDK40.69169435
95SGK20.68958558
96FER0.68749935
97MATK0.68608188
98PDPK10.67667047
99KSR10.67597755
100NTRK10.65066954
101NTRK30.64447410
102PAK60.62107649
103ABL10.61838297
104BLK0.60627651
105RET0.60098861
106PDGFRA0.60082337
107IRAK40.60030606
108DMPK0.59882208
109JAK30.57743475
110PRKG20.57367984
111STK240.55966490
112GSK3A0.55691338
113MET0.55413924
114KIT0.53746905
115PRKAA20.52651001
116IKBKE0.52503979
117PIK3CG0.51888160
118MELK0.50077216
119SGK30.48177439
120STK40.47978434
121PDK10.47673244
122MAP2K10.47154220
123MAP3K110.47052867
124FGFR30.46797446
125SIK20.46432405
126STK110.44072739
127FES0.43808870
128PTK2B0.43365259
129MAPKAPK30.43316882
130WEE10.41711171
131MAP2K40.41090345
132FGFR40.40219473
133GRK60.39696518
134SGK10.37206985
135MAPK100.36993932
136SMG10.36697650

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.81542290
2Nitrogen metabolism_Homo sapiens_hsa009102.53578111
3Leishmaniasis_Homo sapiens_hsa051402.27289211
4Arginine biosynthesis_Homo sapiens_hsa002201.90968169
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.85986000
6* Osteoclast differentiation_Homo sapiens_hsa043801.82361714
7Lysosome_Homo sapiens_hsa041421.78758412
8Caffeine metabolism_Homo sapiens_hsa002321.66655179
9Tuberculosis_Homo sapiens_hsa051521.66488901
10Complement and coagulation cascades_Homo sapiens_hsa046101.58835858
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53898985
12Pertussis_Homo sapiens_hsa051331.50617672
13Long-term potentiation_Homo sapiens_hsa047201.46794011
14Dorso-ventral axis formation_Homo sapiens_hsa043201.44770759
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44150965
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.41617846
17* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.41388120
18* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37285687
19* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36776903
20Sphingolipid metabolism_Homo sapiens_hsa006001.36255964
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.31606109
22Vitamin B6 metabolism_Homo sapiens_hsa007501.29792096
23Thyroid cancer_Homo sapiens_hsa052161.29505856
24* Amoebiasis_Homo sapiens_hsa051461.25602452
25* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24894258
26PPAR signaling pathway_Homo sapiens_hsa033201.24320990
27Legionellosis_Homo sapiens_hsa051341.23342188
28Shigellosis_Homo sapiens_hsa051311.23034665
29* Toxoplasmosis_Homo sapiens_hsa051451.22718854
30Phagosome_Homo sapiens_hsa041451.21611904
31* Inositol phosphate metabolism_Homo sapiens_hsa005621.17349661
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.15966060
33* mTOR signaling pathway_Homo sapiens_hsa041501.15777723
34* ErbB signaling pathway_Homo sapiens_hsa040121.15750950
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15094990
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.14702872
37* Leukocyte transendothelial migration_Homo sapiens_hsa046701.14204860
38* TNF signaling pathway_Homo sapiens_hsa046681.13415159
39Fatty acid biosynthesis_Homo sapiens_hsa000611.11371700
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11329183
41* Apoptosis_Homo sapiens_hsa042101.11079968
42Adherens junction_Homo sapiens_hsa045201.10774219
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10763281
44* Chronic myeloid leukemia_Homo sapiens_hsa052201.08536528
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06742789
46* Endometrial cancer_Homo sapiens_hsa052131.05898041
47* Small cell lung cancer_Homo sapiens_hsa052221.04777736
48* Proteoglycans in cancer_Homo sapiens_hsa052051.00131119
49GnRH signaling pathway_Homo sapiens_hsa049121.00011369
50Salmonella infection_Homo sapiens_hsa051320.98889545
51Bladder cancer_Homo sapiens_hsa052190.97442766
52Malaria_Homo sapiens_hsa051440.96943146
53MicroRNAs in cancer_Homo sapiens_hsa052060.95729174
54* Choline metabolism in cancer_Homo sapiens_hsa052310.94538201
55* B cell receptor signaling pathway_Homo sapiens_hsa046620.93110316
56* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91918252
57* Influenza A_Homo sapiens_hsa051640.91093948
58* Insulin resistance_Homo sapiens_hsa049310.89384829
59* Neurotrophin signaling pathway_Homo sapiens_hsa047220.85720081
60Lysine degradation_Homo sapiens_hsa003100.85083131
61* Pancreatic cancer_Homo sapiens_hsa052120.83675530
62* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83596611
63* Jak-STAT signaling pathway_Homo sapiens_hsa046300.83049984
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82450316
65* Hepatitis B_Homo sapiens_hsa051610.80927063
66Rheumatoid arthritis_Homo sapiens_hsa053230.80747239
67* Phospholipase D signaling pathway_Homo sapiens_hsa040720.80451884
68* T cell receptor signaling pathway_Homo sapiens_hsa046600.79634666
69Renin-angiotensin system_Homo sapiens_hsa046140.79099740
70* Acute myeloid leukemia_Homo sapiens_hsa052210.79037374
71* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79033841
72* Measles_Homo sapiens_hsa051620.77840149
73* VEGF signaling pathway_Homo sapiens_hsa043700.77420223
74* Renal cell carcinoma_Homo sapiens_hsa052110.76962257
75Pancreatic secretion_Homo sapiens_hsa049720.76895381
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76687566
77* Hepatitis C_Homo sapiens_hsa051600.76476659
78* Glioma_Homo sapiens_hsa052140.74028002
79* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73883478
80Hematopoietic cell lineage_Homo sapiens_hsa046400.71955563
81* Chemokine signaling pathway_Homo sapiens_hsa040620.70202592
82* Type II diabetes mellitus_Homo sapiens_hsa049300.70064689
83Endocytosis_Homo sapiens_hsa041440.69899874
84Antigen processing and presentation_Homo sapiens_hsa046120.69735292
85Long-term depression_Homo sapiens_hsa047300.67948577
86* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67054658
87Bile secretion_Homo sapiens_hsa049760.66755094
88African trypanosomiasis_Homo sapiens_hsa051430.66330744
89* Focal adhesion_Homo sapiens_hsa045100.66286434
90* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65751321
91Fructose and mannose metabolism_Homo sapiens_hsa000510.64868033
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64858751
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64443711
94Glycerolipid metabolism_Homo sapiens_hsa005610.63971886
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61901378
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60403631
97* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59662660
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59224353
99* Insulin signaling pathway_Homo sapiens_hsa049100.58392333
100Thyroid hormone synthesis_Homo sapiens_hsa049180.57908213
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57712741
102* Non-small cell lung cancer_Homo sapiens_hsa052230.56920384
103* HIF-1 signaling pathway_Homo sapiens_hsa040660.56421689
104* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55966258
105* FoxO signaling pathway_Homo sapiens_hsa040680.55545705
106Prion diseases_Homo sapiens_hsa050200.55154625
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54662976
108* Central carbon metabolism in cancer_Homo sapiens_hsa052300.53572372
109Circadian rhythm_Homo sapiens_hsa047100.53254118
110p53 signaling pathway_Homo sapiens_hsa041150.52697330
111Pentose phosphate pathway_Homo sapiens_hsa000300.52602778
112Gap junction_Homo sapiens_hsa045400.52394162
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51721162
114* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51635824
115* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51123906
116* AMPK signaling pathway_Homo sapiens_hsa041520.51079105
117* Platelet activation_Homo sapiens_hsa046110.49828271
118Starch and sucrose metabolism_Homo sapiens_hsa005000.48907760
119Viral myocarditis_Homo sapiens_hsa054160.48857733
120Collecting duct acid secretion_Homo sapiens_hsa049660.48645704
121* Prolactin signaling pathway_Homo sapiens_hsa049170.47887448
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47463952
123beta-Alanine metabolism_Homo sapiens_hsa004100.47042238
124Mineral absorption_Homo sapiens_hsa049780.46847690
125Graft-versus-host disease_Homo sapiens_hsa053320.46097193
126* Estrogen signaling pathway_Homo sapiens_hsa049150.45660396
127* Sphingolipid signaling pathway_Homo sapiens_hsa040710.44724512
128* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44664170
129* Prostate cancer_Homo sapiens_hsa052150.44106939
130* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42966152
131Other glycan degradation_Homo sapiens_hsa005110.42811694
132Herpes simplex infection_Homo sapiens_hsa051680.42728712

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