PIGR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfate transmembrane transport (GO:1902358)6.85066938
2positive regulation of respiratory burst (GO:0060267)6.71230755
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.35569536
4L-phenylalanine catabolic process (GO:0006559)6.35569536
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.28697901
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.14987881
7L-phenylalanine metabolic process (GO:0006558)6.14987881
8aromatic amino acid family catabolic process (GO:0009074)5.74270562
9sulfate transport (GO:0008272)5.60514961
10axonemal dynein complex assembly (GO:0070286)5.56518724
11oligosaccharide biosynthetic process (GO:0009312)5.53483399
12glomerular filtration (GO:0003094)5.40969326
13sulfur amino acid catabolic process (GO:0000098)5.39829127
14sperm capacitation (GO:0048240)5.37526530
15urea cycle (GO:0000050)5.35797203
16urea metabolic process (GO:0019627)5.35797203
17complement activation, alternative pathway (GO:0006957)5.24750604
18intestinal cholesterol absorption (GO:0030299)5.23628841
19high-density lipoprotein particle remodeling (GO:0034375)5.21831225
20tryptophan catabolic process (GO:0006569)5.21319736
21indole-containing compound catabolic process (GO:0042436)5.21319736
22indolalkylamine catabolic process (GO:0046218)5.21319736
23calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.17056977
24kynurenine metabolic process (GO:0070189)5.10524253
25cysteine metabolic process (GO:0006534)5.09800461
26regulation of triglyceride catabolic process (GO:0010896)5.03807175
27bundle of His cell to Purkinje myocyte communication (GO:0086069)5.01834897
28alpha-linolenic acid metabolic process (GO:0036109)5.00261669
29bile acid biosynthetic process (GO:0006699)4.99426849
30regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.95035265
31renal filtration (GO:0097205)4.93394476
32regulation of cholesterol esterification (GO:0010872)4.91587094
33tryptophan metabolic process (GO:0006568)4.89525260
34nitrogen cycle metabolic process (GO:0071941)4.88628389
35homocysteine metabolic process (GO:0050667)4.86024549
36glyoxylate metabolic process (GO:0046487)4.85556472
37O-glycan processing (GO:0016266)4.80585619
38negative regulation of sterol transport (GO:0032372)4.78989275
39negative regulation of cholesterol transport (GO:0032375)4.78989275
40regulation of protein activation cascade (GO:2000257)4.77967596
41intestinal absorption (GO:0050892)4.75660509
42phospholipid efflux (GO:0033700)4.73960353
43cilium or flagellum-dependent cell motility (GO:0001539)4.72652055
44bile acid and bile salt transport (GO:0015721)4.71627995
45reverse cholesterol transport (GO:0043691)4.67364851
46bile acid metabolic process (GO:0008206)4.61954896
47drug catabolic process (GO:0042737)4.60471760
48regulation of guanylate cyclase activity (GO:0031282)4.58414264
49angiotensin maturation (GO:0002003)4.56233512
50negative regulation of fibrinolysis (GO:0051918)4.53508748
51regulation of complement activation (GO:0030449)4.52979683
52plasma lipoprotein particle remodeling (GO:0034369)4.52375937
53protein-lipid complex remodeling (GO:0034368)4.52375937
54macromolecular complex remodeling (GO:0034367)4.52375937
55cellular glucuronidation (GO:0052695)4.51677862
56serine family amino acid catabolic process (GO:0009071)4.50837750
57maintenance of gastrointestinal epithelium (GO:0030277)4.49124212
58flavonoid metabolic process (GO:0009812)4.49070153
59regulation of respiratory burst (GO:0060263)4.47893181
60peptidyl-glutamic acid carboxylation (GO:0017187)4.45847457
61protein carboxylation (GO:0018214)4.45847457
62regulation of cellular extravasation (GO:0002691)4.40939276
63fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.39848561
64cellular ketone body metabolic process (GO:0046950)4.39768041
65acylglycerol homeostasis (GO:0055090)4.39645119
66triglyceride homeostasis (GO:0070328)4.39645119
67bicarbonate transport (GO:0015701)4.36221290
68regulation of fibrinolysis (GO:0051917)4.32963255
69antibacterial humoral response (GO:0019731)4.31143608
70regulation of bile acid biosynthetic process (GO:0070857)4.31057536
71cholesterol efflux (GO:0033344)4.27711240
72plasma lipoprotein particle assembly (GO:0034377)4.21374174
73lysine metabolic process (GO:0006553)4.17218236
74lysine catabolic process (GO:0006554)4.17218236
75aromatic amino acid family metabolic process (GO:0009072)4.15969293
76amino-acid betaine metabolic process (GO:0006577)4.14899508
77primary alcohol catabolic process (GO:0034310)4.14724564
78antimicrobial humoral response (GO:0019730)4.09262654
79regulation of cholesterol homeostasis (GO:2000188)4.07019815
80ethanol oxidation (GO:0006069)4.06282083
81positive regulation of lipoprotein lipase activity (GO:0051006)4.04156336
82positive regulation of triglyceride lipase activity (GO:0061365)4.04156336
83positive regulation of pseudopodium assembly (GO:0031274)4.02006511
84alpha-amino acid catabolic process (GO:1901606)4.01284472
85plasma lipoprotein particle clearance (GO:0034381)4.00279903
86glucuronate metabolic process (GO:0019585)4.00152109
87uronic acid metabolic process (GO:0006063)4.00152109
88cellular modified amino acid catabolic process (GO:0042219)4.00140409
89vitamin transmembrane transport (GO:0035461)3.98509700
90glutamate metabolic process (GO:0006536)3.97595634
91cholesterol homeostasis (GO:0042632)3.96031077
92pyrimidine-containing compound transmembrane transport (GO:0072531)3.92293928
93very-low-density lipoprotein particle assembly (GO:0034379)3.92142970
94sterol homeostasis (GO:0055092)3.90756270
95tyrosine metabolic process (GO:0006570)3.90482967
96short-chain fatty acid metabolic process (GO:0046459)3.88627160
97protein-lipid complex assembly (GO:0065005)3.82909854
98intestinal epithelial cell development (GO:0060576)3.79202254
99ketone body metabolic process (GO:1902224)3.79129647
100cellular amino acid catabolic process (GO:0009063)3.77467127
101regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.77311780
102endocrine process (GO:0050886)3.77311780
103regulation of systemic arterial blood pressure by hormone (GO:0001990)3.77311780
104phospholipid homeostasis (GO:0055091)3.76924547
105lipoprotein metabolic process (GO:0042157)3.75330477
1063-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.74951872
107purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.74951872
108drug transmembrane transport (GO:0006855)3.74705096
109sulfur compound transport (GO:0072348)3.71585244
110exogenous drug catabolic process (GO:0042738)3.69991971
111pyrimidine nucleoside catabolic process (GO:0046135)3.67204695
112positive regulation of lipid catabolic process (GO:0050996)3.66361082
113desmosome organization (GO:0002934)3.66239021
114indolalkylamine metabolic process (GO:0006586)3.65860342
115regulation of vitamin metabolic process (GO:0030656)3.65607957
116sodium ion homeostasis (GO:0055078)3.65380290
117cilium movement (GO:0003341)3.65349091
118benzene-containing compound metabolic process (GO:0042537)3.65145465
119arginine metabolic process (GO:0006525)3.64016089
120epoxygenase P450 pathway (GO:0019373)3.61515470
121regulation of pseudopodium assembly (GO:0031272)3.58935845
122UDP-N-acetylglucosamine metabolic process (GO:0006047)3.58914220
123coenzyme catabolic process (GO:0009109)3.58076582
124serine family amino acid metabolic process (GO:0009069)3.56714377
125drug metabolic process (GO:0017144)3.56702757
126ethanol metabolic process (GO:0006067)3.55234571
127renal system process involved in regulation of blood volume (GO:0001977)3.55143230
128plasma lipoprotein particle organization (GO:0071827)3.54041213
129imidazole-containing compound metabolic process (GO:0052803)3.53689176
130motile cilium assembly (GO:0044458)3.53554608
131glycine metabolic process (GO:0006544)3.52808304
132low-density lipoprotein particle remodeling (GO:0034374)3.52359170
133cellular biogenic amine catabolic process (GO:0042402)3.51015652
134amine catabolic process (GO:0009310)3.51015652
135receptor guanylyl cyclase signaling pathway (GO:0007168)3.48828492
136excretion (GO:0007588)3.47096606
137serine family amino acid biosynthetic process (GO:0009070)3.46493685
138negative regulation of lipase activity (GO:0060192)3.43279859
139complement activation, classical pathway (GO:0006958)3.42907856
140response to nitrosative stress (GO:0051409)3.39972700
141organic acid catabolic process (GO:0016054)3.37500601
142carboxylic acid catabolic process (GO:0046395)3.37500601
143positive regulation of guanylate cyclase activity (GO:0031284)3.36532798
144protein-lipid complex subunit organization (GO:0071825)3.36051154
145positive regulation of fatty acid beta-oxidation (GO:0032000)3.35126409
146antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.33225643
147aldehyde catabolic process (GO:0046185)3.32540624
148diterpenoid biosynthetic process (GO:0016102)3.26978386
149antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.25215952
150phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.24577156
151regulation of systemic arterial blood pressure (GO:0003073)3.24526748
152epithelial structure maintenance (GO:0010669)3.23456794
153digestive system process (GO:0022600)3.19247485
154epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14000504
155NADH metabolic process (GO:0006734)3.11393052
156sphingomyelin metabolic process (GO:0006684)3.08462483
157negative regulation of myotube differentiation (GO:0010832)3.05211536
158regulation of intracellular pH (GO:0051453)3.00764735
159protein O-linked glycosylation (GO:0006493)3.00461485
160primary alcohol metabolic process (GO:0034308)2.99342197
161multicellular organismal water homeostasis (GO:0050891)2.97300053
162antigen processing and presentation of endogenous antigen (GO:0019883)2.95469384
163regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.94038811
164drug transport (GO:0015893)2.90183641
165eosinophil chemotaxis (GO:0048245)2.86570634
166lipid translocation (GO:0034204)2.86374716
167phospholipid translocation (GO:0045332)2.86374716
168hormone catabolic process (GO:0042447)2.85547015
169positive regulation of glycoprotein biosynthetic process (GO:0010560)2.83513509
170regulation of cGMP biosynthetic process (GO:0030826)2.82392582
171nucleoside diphosphate biosynthetic process (GO:0009133)2.81391277
172actin filament depolymerization (GO:0030042)2.81338493
173epithelial cilium movement (GO:0003351)2.79388547
174cGMP-mediated signaling (GO:0019934)2.78603608
175digestion (GO:0007586)2.77810981
176monovalent inorganic cation homeostasis (GO:0055067)2.76212653
177antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.74110037
178complement activation (GO:0006956)2.73953748
179regulation of cellular pH (GO:0030641)2.70593707
180regulation of transforming growth factor beta1 production (GO:0032908)2.70016200
181ventricular cardiac muscle cell action potential (GO:0086005)2.69583531
182nucleotide-sugar biosynthetic process (GO:0009226)2.68923002
183transepithelial transport (GO:0070633)2.68675253
184glycosylceramide metabolic process (GO:0006677)2.64733966
185lipoprotein transport (GO:0042953)2.64674767
186positive regulation of glycoprotein metabolic process (GO:1903020)2.64075047

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.44620896
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.54930944
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.05886118
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.92564877
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.78995370
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.37625259
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.22206411
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.63928122
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.99935194
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.64546819
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.49904795
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.24619446
13* CDX2_20551321_ChIP-Seq_CACO-2_Human2.18993405
14SOX2_27498859_Chip-Seq_STOMACH_Mouse2.06245251
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.05396215
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4412874
17* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.82550131
18DROSHA_22980978_ChIP-Seq_HELA_Human1.79597224
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77056144
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.75448191
21* GATA4_25053715_ChIP-Seq_YYC3_Human1.67053055
22FOXA2_19822575_ChIP-Seq_HepG2_Human1.65338014
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65254566
24HNF4A_19822575_ChIP-Seq_HepG2_Human1.52561900
25CLOCK_20551151_ChIP-Seq_293T_Human1.51777051
26KLF5_25053715_ChIP-Seq_YYC3_Human1.50218610
27* TCF4_18268006_ChIP-ChIP_LS174T_Human1.46302121
28ZNF263_19887448_ChIP-Seq_K562_Human1.34862785
29SOX2_20726797_ChIP-Seq_SW620_Human1.31324587
30HTT_18923047_ChIP-ChIP_STHdh_Human1.30294163
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29143923
32FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27578094
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24890244
34GATA6_25053715_ChIP-Seq_YYC3_Human1.23562165
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.21614877
36AHR_22903824_ChIP-Seq_MCF-7_Human1.15987520
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15432602
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15377805
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11065832
40GATA1_22025678_ChIP-Seq_K562_Human1.11024867
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10403573
42* TP63_23658742_ChIP-Seq_EP156T_Human1.08114445
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07510149
44NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05101009
45SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04430072
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03707720
47RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01899726
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.00931710
49* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00285108
50STAT1_20625510_ChIP-Seq_HELA_Human1.00165030
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98306419
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98121886
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97801270
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97776662
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97015162
56PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94432582
57CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94378716
58BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94215271
59ESR1_20079471_ChIP-ChIP_T-47D_Human0.94144168
60ESR1_21235772_ChIP-Seq_MCF-7_Human0.92930483
61SMAD_19615063_ChIP-ChIP_OVARY_Human0.90268950
62ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87959950
63ARNT_22903824_ChIP-Seq_MCF-7_Human0.87091615
64GATA2_21666600_ChIP-Seq_HMVEC_Human0.85644543
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84764672
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84262231
67RXR_22108803_ChIP-Seq_LS180_Human0.83799566
68TRIM28_21343339_ChIP-Seq_HEK293_Human0.83067196
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82780264
70CJUN_26792858_Chip-Seq_BT549_Human0.82000846
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.81262311
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81004248
73* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80246281
74* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80217737
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79589609
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79111635
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78830519
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78826608
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78791427
80SMAD3_21741376_ChIP-Seq_HESCs_Human0.77985726
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77771019
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.76873242
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76536377
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76442389
85IRF8_27001747_Chip-Seq_BMDM_Mouse0.75714887
86RARA_24833708_ChIP-Seq_LIVER_Mouse0.75597449
87AR_21909140_ChIP-Seq_LNCAP_Human0.75413426
88TP63_22573176_ChIP-Seq_HFKS_Human0.74509447
89KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74442833
90TBX20_22328084_ChIP-Seq_HEART_Mouse0.74292574
91TBX20_22080862_ChIP-Seq_HEART_Mouse0.74292574
92EGR1_19032775_ChIP-ChIP_M12_Human0.73554873
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.73526358
94FOXA1_25552417_ChIP-Seq_VCAP_Human0.72838505
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.72232693
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.71893327
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71851100
98RACK7_27058665_Chip-Seq_MCF-7_Human0.71836233
99GATA2_19941826_ChIP-Seq_K562_Human0.71481070
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70450741
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69254007
102NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69254007
103BCAT_22108803_ChIP-Seq_LS180_Human0.68823454
104RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68320486
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67095082
106GATA3_24758297_ChIP-Seq_MCF-7_Human0.66924316
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.66692345
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.64679104
109LXR_22292898_ChIP-Seq_THP-1_Human0.64534237
110CREB1_26743006_Chip-Seq_LNCaP_Human0.62792005
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.61516865
112FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.61115068
113CEBPB_22108803_ChIP-Seq_LS180_Human0.60179045
114ATF3_27146783_Chip-Seq_COLON_Human0.59114859
115MYC_19915707_ChIP-ChIP_AK7_Human0.58798605
116AR_20517297_ChIP-Seq_VCAP_Human0.58256424
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.57973916
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56970538
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.56922418
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.56621739
121RUNX1_27514584_Chip-Seq_MCF-7_Human0.56530333
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.56466791
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.56226812
124RARB_24833708_ChIP-Seq_LIVER_Mouse0.56145994
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.55826419
126CDX2_22108803_ChIP-Seq_LS180_Human0.55021288
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.54286741
128SRY_22984422_ChIP-ChIP_TESTIS_Rat0.52627055
129GATA1_19941826_ChIP-Seq_K562_Human0.52310033
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51856973
131STAT1_17558387_ChIP-Seq_HELA_Human0.50970246
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.50223061
133* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.50096402
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.49266570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.02968482
2MP0002139_abnormal_hepatobiliary_system7.49269410
3MP0005085_abnormal_gallbladder_physiolo6.14368880
4MP0005365_abnormal_bile_salt5.33279505
5MP0008875_abnormal_xenobiotic_pharmacok4.85338525
6MP0003252_abnormal_bile_duct4.51761132
7MP0003806_abnormal_nucleotide_metabolis3.74011180
8MP0001666_abnormal_nutrient_absorption3.56341638
9MP0010329_abnormal_lipoprotein_level3.33296442
10MP0009840_abnormal_foam_cell3.25316276
11MP0010352_gastrointestinal_tract_polyps2.69546755
12* MP0001664_abnormal_digestion2.55006591
13MP0005083_abnormal_biliary_tract2.51874832
14MP0005332_abnormal_amino_acid2.47343502
15MP0003183_abnormal_peptide_metabolism2.30547796
16MP0004019_abnormal_vitamin_homeostasis2.26248990
17MP0000490_abnormal_crypts_of2.16569586
18MP0003195_calcinosis2.10248427
19MP0010234_abnormal_vibrissa_follicle2.00610544
20MP0000465_gastrointestinal_hemorrhage1.95719782
21MP0000609_abnormal_liver_physiology1.95486353
22MP0003191_abnormal_cellular_cholesterol1.86817140
23MP0002118_abnormal_lipid_homeostasis1.86257026
24MP0004264_abnormal_extraembryonic_tissu1.83042393
25MP0003300_gastrointestinal_ulcer1.82021786
26MP0002138_abnormal_hepatobiliary_system1.79774473
27MP0005670_abnormal_white_adipose1.74883253
28MP0003868_abnormal_feces_composition1.70187225
29MP0005319_abnormal_enzyme/_coenzyme1.67644051
30MP0005409_darkened_coat_color1.66032805
31MP0003724_increased_susceptibility_to1.60500263
32MP0003705_abnormal_hypodermis_morpholog1.59951263
33MP0002132_abnormal_respiratory_system1.57087146
34MP0002277_abnormal_respiratory_mucosa1.54886167
35MP0002166_altered_tumor_susceptibility1.41951744
36MP0000678_abnormal_parathyroid_gland1.41112779
37MP0009643_abnormal_urine_homeostasis1.38486714
38MP0003303_peritoneal_inflammation1.34903573
39MP0005584_abnormal_enzyme/coenzyme_acti1.33611117
40MP0005451_abnormal_body_composition1.33264446
41MP0009697_abnormal_copulation1.30650698
42MP0009780_abnormal_chondrocyte_physiolo1.28006775
43MP0000566_synostosis1.27148429
44MP0010678_abnormal_skin_adnexa1.23717238
45MP0002254_reproductive_system_inflammat1.23696890
46MP0005165_increased_susceptibility_to1.17944835
47MP0005310_abnormal_salivary_gland1.16186072
48* MP0001764_abnormal_homeostasis1.14376840
49MP0008004_abnormal_stomach_pH1.12960625
50MP0004858_abnormal_nervous_system1.10082436
51MP0005636_abnormal_mineral_homeostasis1.06491387
52MP0003866_abnormal_defecation1.06037199
53MP0000462_abnormal_digestive_system1.01909546
54MP0001188_hyperpigmentation0.99909634
55MP0002822_catalepsy0.99561547
56MP0002006_tumorigenesis0.99104186
57MP0010155_abnormal_intestine_physiology0.98662313
58MP0000598_abnormal_liver_morphology0.98624001
59MP0005647_abnormal_sex_gland0.96966111
60MP0002896_abnormal_bone_mineralization0.96661044
61MP0000604_amyloidosis0.94860798
62MP0009764_decreased_sensitivity_to0.94100629
63MP0000230_abnormal_systemic_arterial0.91133970
64MP0002796_impaired_skin_barrier0.90373507
65MP0009785_altered_susceptibility_to0.89583575
66MP0003656_abnormal_erythrocyte_physiolo0.88194104
67MP0003718_maternal_effect0.86140208
68MP0001663_abnormal_digestive_system0.85429934
69MP0003186_abnormal_redox_activity0.84779267
70MP0003011_delayed_dark_adaptation0.82432383
71MP0005084_abnormal_gallbladder_morpholo0.82339501
72MP0008469_abnormal_protein_level0.81727246
73MP0009642_abnormal_blood_homeostasis0.81025569
74MP0005381_digestive/alimentary_phenotyp0.80991402
75* MP0005025_abnormal_response_to0.78882497
76MP0009765_abnormal_xenobiotic_induced0.78662851
77MP0006082_CNS_inflammation0.78090886
78MP0002876_abnormal_thyroid_physiology0.77796898
79MP0000470_abnormal_stomach_morphology0.77296114
80MP0009763_increased_sensitivity_to0.77210073
81MP0003045_fibrosis0.76603153
82MP0001881_abnormal_mammary_gland0.74257574
83MP0001485_abnormal_pinna_reflex0.73775139
84MP0005023_abnormal_wound_healing0.72811857
85MP0009053_abnormal_anal_canal0.72126465
86MP0002928_abnormal_bile_duct0.71278148
87MP0001849_ear_inflammation0.69942098
88MP0004043_abnormal_pH_regulation0.69313056
89* MP0005376_homeostasis/metabolism_phenot0.68689376
90MP0006036_abnormal_mitochondrial_physio0.67166849
91MP0001501_abnormal_sleep_pattern0.66886935
92MP0005408_hypopigmentation0.66623439
93MP0005448_abnormal_energy_balance0.66085016
94MP0001533_abnormal_skeleton_physiology0.65904362
95MP0000681_abnormal_thyroid_gland0.64880343
96MP0005166_decreased_susceptibility_to0.64116833
97MP0005266_abnormal_metabolism0.64094601
98MP0000249_abnormal_blood_vessel0.63848284
99* MP0000477_abnormal_intestine_morphology0.63687535
100MP0010386_abnormal_urinary_bladder0.63604418
101MP0001756_abnormal_urination0.63550630
102MP0004484_altered_response_of0.63352091
103MP0002078_abnormal_glucose_homeostasis0.63195351
104MP0008872_abnormal_physiological_respon0.62504887
105MP0000538_abnormal_urinary_bladder0.62409203
106MP0005220_abnormal_exocrine_pancreas0.61041268
107MP0003453_abnormal_keratinocyte_physiol0.60410157
108MP0003879_abnormal_hair_cell0.59196559
109MP0003436_decreased_susceptibility_to0.59151597
110MP0005501_abnormal_skin_physiology0.58776159
111MP0005395_other_phenotype0.58748959
112* MP0001790_abnormal_immune_system0.58552217
113* MP0005387_immune_system_phenotype0.58552217
114MP0002136_abnormal_kidney_physiology0.58223856
115MP0002098_abnormal_vibrissa_morphology0.58158816
116MP0000627_abnormal_mammary_gland0.57622047
117MP0001873_stomach_inflammation0.57514745
118MP0001765_abnormal_ion_homeostasis0.57132999
119MP0002998_abnormal_bone_remodeling0.54474642
120MP0002009_preneoplasia0.52700472
121MP0002971_abnormal_brown_adipose0.52675360
122MP0004782_abnormal_surfactant_physiolog0.51675689
123MP0005334_abnormal_fat_pad0.51620195
124MP0000537_abnormal_urethra_morphology0.48859796
125MP0004947_skin_inflammation0.47795532
126MP0005167_abnormal_blood-brain_barrier0.47475925
127MP0010368_abnormal_lymphatic_system0.46171580
128MP0003329_amyloid_beta_deposits0.45658089
129MP0000467_abnormal_esophagus_morphology0.45215810
130MP0009384_cardiac_valve_regurgitation0.45120839
131MP0008873_increased_physiological_sensi0.44809746
132MP0004883_abnormal_blood_vessel0.41963932
133MP0009379_abnormal_foot_pigmentation0.41758689
134MP0001243_abnormal_dermal_layer0.41547412
135MP0005464_abnormal_platelet_physiology0.41390937
136MP0003638_abnormal_response/metabolism_0.41379400
137MP0004147_increased_porphyrin_level0.41303437
138MP0003075_altered_response_to0.40787947
139MP0006035_abnormal_mitochondrial_morpho0.40689677
140MP0002060_abnormal_skin_morphology0.40219837
141MP0005666_abnormal_adipose_tissue0.39456814
142MP0004130_abnormal_muscle_cell0.38896000
143MP0001845_abnormal_inflammatory_respons0.38597441

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)9.89311272
2Intrahepatic cholestasis (HP:0001406)6.86434237
3Hypobetalipoproteinemia (HP:0003563)6.70914191
4Deep venous thrombosis (HP:0002625)6.34989121
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.30798677
6Decreased circulating renin level (HP:0003351)6.24546215
7Abnormality of aromatic amino acid family metabolism (HP:0004338)6.20642137
8Abnormality of renin-angiotensin system (HP:0000847)6.00399980
9Flat acetabular roof (HP:0003180)5.96118955
10Xanthomatosis (HP:0000991)5.81125615
11Metabolic alkalosis (HP:0200114)5.54107241
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.45882775
13Prolonged partial thromboplastin time (HP:0003645)5.41556163
14Abnormality of glutamine family amino acid metabolism (HP:0010902)5.36250401
15Abnormality of chloride homeostasis (HP:0011422)5.34309134
16Hyperaldosteronism (HP:0000859)4.98950211
17Chronic bronchitis (HP:0004469)4.96281169
18Hypolipoproteinemia (HP:0010981)4.68862317
19Rhinitis (HP:0012384)4.61990087
20Abnormal respiratory motile cilium physiology (HP:0012261)4.57944018
21Fat malabsorption (HP:0002630)4.51543269
22Abnormal respiratory epithelium morphology (HP:0012253)4.50314200
23Abnormal respiratory motile cilium morphology (HP:0005938)4.50314200
24Hyperglycinuria (HP:0003108)4.47620489
25Conjugated hyperbilirubinemia (HP:0002908)4.43150990
26Complement deficiency (HP:0004431)4.42037004
27Hyperammonemia (HP:0001987)4.41708360
28Hyperlipoproteinemia (HP:0010980)4.38957333
29Abnormal ciliary motility (HP:0012262)4.38543664
30Dynein arm defect of respiratory motile cilia (HP:0012255)4.32530478
31Absent/shortened dynein arms (HP:0200106)4.32530478
32Epidermoid cyst (HP:0200040)4.25591523
33Abnormality of serine family amino acid metabolism (HP:0010894)4.19623632
34Abnormality of glycine metabolism (HP:0010895)4.19623632
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.14732262
36Bronchiectasis (HP:0002110)4.05818755
37Abnormality of sulfur amino acid metabolism (HP:0004339)4.05790770
38Hyperglycinemia (HP:0002154)3.98484824
39Abnormality of aspartate family amino acid metabolism (HP:0010899)3.88127339
40Neonatal short-limb short stature (HP:0008921)3.87922289
41Joint hemorrhage (HP:0005261)3.87745829
42Abnormality of the nasal mucosa (HP:0000433)3.85756182
43Hyponatremia (HP:0002902)3.84378280
44Hypoglycemic coma (HP:0001325)3.80209639
45Abnormality of the common coagulation pathway (HP:0010990)3.74404355
46Ketosis (HP:0001946)3.72550772
47Flattened epiphyses (HP:0003071)3.68099621
48Nasal polyposis (HP:0100582)3.62129065
49Hypoalphalipoproteinemia (HP:0003233)3.57119118
50Acanthocytosis (HP:0001927)3.54541604
51Hydroxyprolinuria (HP:0003080)3.45971863
52Abnormality of proline metabolism (HP:0010907)3.45971863
53Hypercholesterolemia (HP:0003124)3.44995656
54Abnormality of methionine metabolism (HP:0010901)3.39453011
55Flat capital femoral epiphysis (HP:0003370)3.39208688
56Spinal cord compression (HP:0002176)3.38474696
57Malnutrition (HP:0004395)3.32750405
58Ileus (HP:0002595)3.31661681
59Hyperkalemia (HP:0002153)3.27619811
60Abnormality of pyrimidine metabolism (HP:0004353)3.24023008
61Abnormality of complement system (HP:0005339)3.23524296
62Abnormality of the distal phalanx of the thumb (HP:0009617)3.21671800
63Abnormality of fatty-acid metabolism (HP:0004359)3.12481598
64Abnormality of the intrinsic pathway (HP:0010989)3.12473190
65Hyperbilirubinemia (HP:0002904)3.11739833
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.10527380
67Abnormality of nucleobase metabolism (HP:0010932)3.05094839
68Bronchitis (HP:0012387)3.01577628
69Hypokalemia (HP:0002900)3.00621277
70Visceral angiomatosis (HP:0100761)3.00024974
71Dicarboxylic aciduria (HP:0003215)2.95713141
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.95713141
73Abnormality of purine metabolism (HP:0004352)2.95630755
74Steatorrhea (HP:0002570)2.94024887
75Abnormality of sodium homeostasis (HP:0010931)2.93894610
76Metabolic acidosis (HP:0001942)2.90413278
77Abnormality of potassium homeostasis (HP:0011042)2.86751388
78Myocardial infarction (HP:0001658)2.79191038
79Ketoacidosis (HP:0001993)2.78832503
80Vascular calcification (HP:0004934)2.77768880
81Abnormal vertebral ossification (HP:0100569)2.74588628
82Abnormal biliary tract morphology (HP:0012440)2.73652358
83Hemangiomatosis (HP:0007461)2.70313136
84Adrenal overactivity (HP:0002717)2.66346125
85Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.64947149
86Vertebral hypoplasia (HP:0008417)2.64947149
87Spontaneous abortion (HP:0005268)2.64499395
88Breech presentation (HP:0001623)2.58952294
89Hepatocellular carcinoma (HP:0001402)2.57376728
90Skin nodule (HP:0200036)2.55860302
91Poikilocytosis (HP:0004447)2.53967679
92Lethargy (HP:0001254)2.53448504
93Delayed CNS myelination (HP:0002188)2.47767074
94Right ventricular cardiomyopathy (HP:0011663)2.46660654
95Cardiovascular calcification (HP:0011915)2.46453742
96Abnormality of serum amino acid levels (HP:0003112)2.45875274
97Chronic diarrhea (HP:0002028)2.45313928
98Abnormality of small intestinal villus morphology (HP:0011472)2.43864151
99Villous atrophy (HP:0011473)2.43864151
100Vertebral clefting (HP:0008428)2.40370076
101Esophageal varix (HP:0002040)2.40281237
102Recurrent sinusitis (HP:0011108)2.40190633
103Hypoglycemic seizures (HP:0002173)2.39230507
104Gout (HP:0001997)2.37631089
105Pancreatitis (HP:0001733)2.35790329
106Dehydration (HP:0001944)2.32440526
107Male infertility (HP:0003251)2.31647386
108Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.29771612
109Systemic lupus erythematosus (HP:0002725)2.27152297
110Large earlobe (HP:0009748)2.25557941
111Alkalosis (HP:0001948)2.25290476
112Late onset (HP:0003584)2.21596292
113Spastic diplegia (HP:0001264)2.21293701
114Rectal prolapse (HP:0002035)2.21063480
115Neonatal onset (HP:0003623)2.19293309
116Abnormal gallbladder morphology (HP:0012437)2.19220908
117Abnormality of urine glucose concentration (HP:0011016)2.18733837
118Glycosuria (HP:0003076)2.18733837
119Abnormal cartilage morphology (HP:0002763)2.18120210
120Renal salt wasting (HP:0000127)2.16689588
121Abnormality of vitamin metabolism (HP:0100508)2.16438932
122Hypochromic microcytic anemia (HP:0004840)2.15988893
123Cholelithiasis (HP:0001081)2.15475994
124Renal tubular acidosis (HP:0001947)2.13182287
125Sensorimotor neuropathy (HP:0007141)2.13151011
126Chronic otitis media (HP:0000389)2.12883910
127Abnormal tarsal ossification (HP:0008369)2.12706529
128Irritability (HP:0000737)2.12498561
129Chronic sinusitis (HP:0011109)2.12488899
130Glomerulonephritis (HP:0000099)2.12445771
131Cholecystitis (HP:0001082)2.11457765
132Abnormal gallbladder physiology (HP:0012438)2.11457765
133Hypotension (HP:0002615)2.10138081
134Symphalangism affecting the phalanges of the hand (HP:0009773)2.07404329
135Abnormality of the vitamin B12 metabolism (HP:0004341)2.05145398
136Syncope (HP:0001279)2.04362651
137Cerebral edema (HP:0002181)2.02472582
138Generalized aminoaciduria (HP:0002909)2.02454387
139Amyloidosis (HP:0011034)2.02167964
140Congenital sensorineural hearing impairment (HP:0008527)2.01621228
141Vomiting (HP:0002013)2.01325504
142Abdominal distention (HP:0003270)1.99499362
143Aplasia/hypoplasia of the femur (HP:0005613)1.98854247
144Symptomatic seizures (HP:0011145)1.98240202
145Eczematoid dermatitis (HP:0000976)1.97725256
146Irregular epiphyses (HP:0010582)1.97101741
147Abnormality of carpal bone ossification (HP:0006257)1.96849202
148Rickets (HP:0002748)1.93909117
149Hemorrhage of the eye (HP:0011885)1.93590707
150Ventricular fibrillation (HP:0001663)1.93548586
151Hoarse voice (HP:0001609)1.92627054
152Hip contracture (HP:0003273)1.91586531
153Nephritis (HP:0000123)1.90799683
154Proximal tubulopathy (HP:0000114)1.90614190
155Pili torti (HP:0003777)1.90544635
156Abnormality of vitamin B metabolism (HP:0004340)1.90265006
157Hyperinsulinemic hypoglycemia (HP:0000825)1.90050109
158Infertility (HP:0000789)1.89496370
159Gingival bleeding (HP:0000225)1.89202969
160Menorrhagia (HP:0000132)1.86490172
161Recurrent otitis media (HP:0000403)1.85542823
162Abnormality of the gallbladder (HP:0005264)1.84390993
163Hip dysplasia (HP:0001385)1.83532254
164Hyperparathyroidism (HP:0000843)1.83104653
165Abnormality of transition element cation homeostasis (HP:0011030)1.82706327
166Reticulocytosis (HP:0001923)1.82705856
167Severe short stature (HP:0003510)1.80321266
168Pigmentary retinal degeneration (HP:0001146)1.79578909
169Protuberant abdomen (HP:0001538)1.78935864
170Increased mean platelet volume (HP:0011877)1.78543256
171Nephrolithiasis (HP:0000787)1.77815720
172Abnormal enzyme/coenzyme activity (HP:0012379)1.75949570
173Short middle phalanx of finger (HP:0005819)1.71606131
174Biliary tract neoplasm (HP:0100574)1.70596702
175Abnormal foot bone ossification (HP:0010675)1.69162294
176Recurrent bronchitis (HP:0002837)1.67718944
177Palpitations (HP:0001962)1.66216369
178Interstitial pulmonary disease (HP:0006530)1.65582779
179Widely patent fontanelles and sutures (HP:0004492)1.65499542
180Focal segmental glomerulosclerosis (HP:0000097)1.65038264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.95602530
2NUAK14.73190207
3BCKDK3.74258037
4FRK3.69701957
5MST43.67346851
6MST1R3.57231021
7STK38L3.39174907
8PIK3CA3.29395157
9ERN13.10108917
10MAP3K73.00158212
11LMTK22.95337576
12SIK12.62280439
13FGFR42.60962210
14TAOK32.39662049
15MAP2K22.22284820
16DMPK2.18000223
17STK242.10084648
18PKN22.04817439
19EPHB21.89896431
20PTK61.82876088
21ERBB41.65662024
22INSRR1.61053521
23PDK21.43568667
24GRK61.42590571
25LATS11.41483304
26PRKG21.38481777
27TRIB31.35993039
28EPHA21.34635461
29RIPK11.31734970
30RAF11.31213755
31ERBB21.28667099
32PIK3CG1.27018488
33MAP3K121.26212363
34FGFR31.23236750
35TEC1.22413224
36MET1.20607949
37MAPK111.16275309
38TYK21.16275115
39MAP3K101.14839845
40NLK1.12959464
41STK391.06118170
42MAPKAPK30.98149126
43MAP3K20.97911172
44STK380.95853995
45PRKAA20.95239855
46MAP2K10.94897220
47TBK10.94895833
48MAP2K40.91632748
49PDPK10.90628440
50MAP2K60.87139853
51MYLK0.86038946
52AKT30.84140702
53EEF2K0.82772013
54CSK0.81319551
55FLT30.77785479
56TAOK10.77755707
57DDR20.74948590
58EPHB10.74192096
59CDC42BPA0.74017034
60SMG10.73114508
61NME10.67536584
62OXSR10.67395450
63KDR0.67075387
64PDK10.66826221
65FER0.66039757
66BCR0.65597121
67ABL20.65114630
68IRAK10.64349329
69PTK20.62903960
70DAPK20.61488970
71JAK20.60798404
72PRKCQ0.60039849
73RIPK40.59052638
74BMPR20.58994999
75WNK40.57649843
76CDK60.55498112
77PRKAA10.50849226
78MAP3K30.50650922
79CDK40.48556891
80PRKCZ0.48384709
81GRK10.46973335
82ILK0.46328590
83NEK90.45991881
84ZAP700.45324034
85JAK10.45147776
86PRKACG0.44994465
87FGFR20.44724389
88PAK40.43751074
89RET0.43689206
90CAMK2G0.41050001
91CAMK2D0.40526225
92PBK0.40045165
93SRC0.39994955
94MATK0.39709904
95MAPK40.39673346
96GSK3A0.39531320
97MAPKAPK20.38633717
98DYRK1B0.38489007
99TRPM70.38437976
100MAP3K110.38146650
101IKBKE0.38028342
102CASK0.36850965
103YES10.34538048
104FYN0.34165972
105PRKCI0.33530018
106PRPF4B0.33237434
107RPS6KA20.33158939
108TESK20.32804931
109MAPK150.32034477
110BMX0.31738210
111PRKCD0.31509628
112IRAK30.30977960
113PKN10.30578066
114MAP3K10.29402461
115MAP3K140.28580073
116PRKCA0.28127128
117ERBB30.27999636
118ROCK10.27763929
119STK30.27664462
120KSR20.27107592
121TNIK0.25720187
122IGF1R0.25632413
123NEK60.25500739
124PRKG10.25004682
125CAMK1D0.24878575
126TESK10.23281406
127PDGFRB0.22407418
128CSNK1A10.22360015
129PRKACB0.22348138
130ICK0.21919501
131LRRK20.21018384
132PAK30.20809488
133EPHA30.20771880
134MAP2K30.20374701
135PDK40.19827922
136PDK30.19827922
137MELK0.18718963
138MAPK70.18429038
139BRSK20.16608798
140SGK10.14567941

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.76920486
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.54581657
3Nitrogen metabolism_Homo sapiens_hsa009103.52875718
4Arginine biosynthesis_Homo sapiens_hsa002202.82033724
5Tryptophan metabolism_Homo sapiens_hsa003802.62070574
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.59600683
7Fatty acid degradation_Homo sapiens_hsa000712.57374341
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.35976658
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.35723209
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.28931915
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27223583
12Complement and coagulation cascades_Homo sapiens_hsa046102.25547244
13Caffeine metabolism_Homo sapiens_hsa002322.22882838
14Butanoate metabolism_Homo sapiens_hsa006502.22429241
15Fat digestion and absorption_Homo sapiens_hsa049752.16098381
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14442198
17Sulfur metabolism_Homo sapiens_hsa009202.13189921
18Histidine metabolism_Homo sapiens_hsa003402.07433779
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06861703
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88580220
21Chemical carcinogenesis_Homo sapiens_hsa052041.86742824
22Peroxisome_Homo sapiens_hsa041461.82472251
23PPAR signaling pathway_Homo sapiens_hsa033201.80905493
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.80063622
25Bile secretion_Homo sapiens_hsa049761.79257710
26Propanoate metabolism_Homo sapiens_hsa006401.78213815
27Fatty acid metabolism_Homo sapiens_hsa012121.72554237
28Retinol metabolism_Homo sapiens_hsa008301.71965443
29Starch and sucrose metabolism_Homo sapiens_hsa005001.65118962
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.63995618
31Pyruvate metabolism_Homo sapiens_hsa006201.63621642
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61736489
33beta-Alanine metabolism_Homo sapiens_hsa004101.61103498
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57444460
35Staphylococcus aureus infection_Homo sapiens_hsa051501.51831763
36Tyrosine metabolism_Homo sapiens_hsa003501.45127790
37Folate biosynthesis_Homo sapiens_hsa007901.43233433
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40660686
39Vitamin digestion and absorption_Homo sapiens_hsa049771.36686189
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.36599281
41Selenocompound metabolism_Homo sapiens_hsa004501.35339830
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33865268
43Phenylalanine metabolism_Homo sapiens_hsa003601.29723572
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28769912
45Carbon metabolism_Homo sapiens_hsa012001.27420554
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24718176
47ABC transporters_Homo sapiens_hsa020101.21139232
48Steroid biosynthesis_Homo sapiens_hsa001001.15670361
49Fatty acid elongation_Homo sapiens_hsa000621.14439450
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14413300
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.10057059
52Arginine and proline metabolism_Homo sapiens_hsa003301.08231124
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02869630
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.01537826
55Biosynthesis of amino acids_Homo sapiens_hsa012301.00375471
56Asthma_Homo sapiens_hsa053100.99712804
57Galactose metabolism_Homo sapiens_hsa000520.90452068
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.89654077
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86592982
60Glycerolipid metabolism_Homo sapiens_hsa005610.85705347
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85659336
62Glutathione metabolism_Homo sapiens_hsa004800.84899833
63Allograft rejection_Homo sapiens_hsa053300.84615376
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83046682
65Sulfur relay system_Homo sapiens_hsa041220.79116286
66Autoimmune thyroid disease_Homo sapiens_hsa053200.79103843
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78652284
68Sphingolipid metabolism_Homo sapiens_hsa006000.75492942
69Graft-versus-host disease_Homo sapiens_hsa053320.75328232
70* Intestinal immune network for IgA production_Homo sapiens_hsa046720.73822876
71Mineral absorption_Homo sapiens_hsa049780.72043037
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68929096
73Renin-angiotensin system_Homo sapiens_hsa046140.67677836
74Lysine degradation_Homo sapiens_hsa003100.67396499
75Fructose and mannose metabolism_Homo sapiens_hsa000510.63768962
76Pentose phosphate pathway_Homo sapiens_hsa000300.62690082
77Type I diabetes mellitus_Homo sapiens_hsa049400.60123256
78Renin secretion_Homo sapiens_hsa049240.56963135
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56888960
80Fatty acid biosynthesis_Homo sapiens_hsa000610.55883209
81Other glycan degradation_Homo sapiens_hsa005110.52932709
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49503382
83Metabolic pathways_Homo sapiens_hsa011000.49120953
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46546689
85Vitamin B6 metabolism_Homo sapiens_hsa007500.42701885
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40776167
87Pertussis_Homo sapiens_hsa051330.40520917
88Linoleic acid metabolism_Homo sapiens_hsa005910.38734962
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37443802
90Antigen processing and presentation_Homo sapiens_hsa046120.35565878
91Salivary secretion_Homo sapiens_hsa049700.30017258
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30013507
93Vibrio cholerae infection_Homo sapiens_hsa051100.28859021
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.27725495
95One carbon pool by folate_Homo sapiens_hsa006700.27589925
96Leishmaniasis_Homo sapiens_hsa051400.26788484
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24474274
98Insulin resistance_Homo sapiens_hsa049310.21727621
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21157654
100Protein digestion and absorption_Homo sapiens_hsa049740.21070450
101Viral myocarditis_Homo sapiens_hsa054160.18315823
102Amoebiasis_Homo sapiens_hsa051460.16698983
103Gastric acid secretion_Homo sapiens_hsa049710.15472052
104Choline metabolism in cancer_Homo sapiens_hsa052310.15106430
105Toxoplasmosis_Homo sapiens_hsa051450.14145771
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.13603767
107Hematopoietic cell lineage_Homo sapiens_hsa046400.13237191
108Salmonella infection_Homo sapiens_hsa051320.11842183
109Influenza A_Homo sapiens_hsa051640.11149780
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.08680886
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08212924
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06470583
113Thyroid hormone synthesis_Homo sapiens_hsa049180.06001034
114Prion diseases_Homo sapiens_hsa050200.05086752
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.03357193
116AMPK signaling pathway_Homo sapiens_hsa041520.02980994
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1594325
118Pancreatic secretion_Homo sapiens_hsa04972-0.1514251
119Ether lipid metabolism_Homo sapiens_hsa00565-0.1508670
120Bladder cancer_Homo sapiens_hsa05219-0.1409408
121Insulin signaling pathway_Homo sapiens_hsa04910-0.1298144
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0995767
123Hepatitis C_Homo sapiens_hsa05160-0.0912364
124Tight junction_Homo sapiens_hsa04530-0.0849346
125Adherens junction_Homo sapiens_hsa04520-0.0368293
126Glucagon signaling pathway_Homo sapiens_hsa04922-0.0324769
127Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0149600
128African trypanosomiasis_Homo sapiens_hsa05143-0.0085496
129Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0082691

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