PIGL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI). Study of a similar rat enzyme suggests that this protein localizes to the endoplasmic reticulum. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleoside diphosphate catabolic process (GO:0009134)6.00481400
2L-fucose catabolic process (GO:0042355)5.52048257
3fucose catabolic process (GO:0019317)5.52048257
4L-fucose metabolic process (GO:0042354)5.52048257
5DNA deamination (GO:0045006)5.44552198
6rRNA modification (GO:0000154)5.32504203
7maturation of SSU-rRNA (GO:0030490)5.27218006
8ribosomal small subunit biogenesis (GO:0042274)5.17967351
9prenylation (GO:0097354)4.86619568
10protein prenylation (GO:0018342)4.86619568
11behavioral response to nicotine (GO:0035095)4.86095344
12protein-cofactor linkage (GO:0018065)4.64420115
13rRNA methylation (GO:0031167)4.57083094
14viral transcription (GO:0019083)4.54731507
15telomere maintenance via semi-conservative replication (GO:0032201)4.47369750
16regulation of nuclear cell cycle DNA replication (GO:0033262)4.44874861
17translational termination (GO:0006415)4.44018121
18transcription elongation from RNA polymerase III promoter (GO:0006385)4.37118523
19termination of RNA polymerase III transcription (GO:0006386)4.37118523
20kinetochore assembly (GO:0051382)4.31280383
21ribosomal large subunit biogenesis (GO:0042273)4.23063731
22ribonucleoprotein complex biogenesis (GO:0022613)4.16043483
23spliceosomal snRNP assembly (GO:0000387)4.13430324
24termination of RNA polymerase I transcription (GO:0006363)4.12908465
25proteasome assembly (GO:0043248)4.09961606
26ribosomal small subunit assembly (GO:0000028)4.06374438
277-methylguanosine mRNA capping (GO:0006370)4.06191472
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.05885737
29RNA capping (GO:0036260)3.98719901
307-methylguanosine RNA capping (GO:0009452)3.98719901
31DNA strand elongation involved in DNA replication (GO:0006271)3.98201361
32telomere maintenance via recombination (GO:0000722)3.96753537
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.96315321
34NADH dehydrogenase complex assembly (GO:0010257)3.96315321
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.96315321
36transcription-coupled nucleotide-excision repair (GO:0006283)3.91878248
37transcription from RNA polymerase I promoter (GO:0006360)3.88870717
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.87360557
39rRNA processing (GO:0006364)3.83222913
40kinetochore organization (GO:0051383)3.83200938
41transcription elongation from RNA polymerase I promoter (GO:0006362)3.82220573
42cotranslational protein targeting to membrane (GO:0006613)3.82002664
43spliceosomal complex assembly (GO:0000245)3.81471923
44pseudouridine synthesis (GO:0001522)3.81245949
45CENP-A containing nucleosome assembly (GO:0034080)3.80544872
46ribosome biogenesis (GO:0042254)3.80443399
47protein complex biogenesis (GO:0070271)3.79806144
48DNA strand elongation (GO:0022616)3.78836163
49protein targeting to ER (GO:0045047)3.77538564
50translational elongation (GO:0006414)3.74050325
51epithelial cilium movement (GO:0003351)3.73561950
52chromatin remodeling at centromere (GO:0031055)3.72261904
53telomere maintenance via telomere lengthening (GO:0010833)3.69028875
54rRNA metabolic process (GO:0016072)3.68712086
55regulation of helicase activity (GO:0051095)3.68443095
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.64980073
57water-soluble vitamin biosynthetic process (GO:0042364)3.64787349
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.64429438
59translational initiation (GO:0006413)3.64089344
60DNA replication initiation (GO:0006270)3.63605469
61mitotic recombination (GO:0006312)3.61140821
62DNA replication checkpoint (GO:0000076)3.60577301
63translation (GO:0006412)3.59941672
64DNA damage response, detection of DNA damage (GO:0042769)3.58832350
65maturation of 5.8S rRNA (GO:0000460)3.58127529
66nucleotide-excision repair, DNA gap filling (GO:0006297)3.57793874
67mitochondrial respiratory chain complex assembly (GO:0033108)3.57689697
68establishment of protein localization to endoplasmic reticulum (GO:0072599)3.55330433
69metallo-sulfur cluster assembly (GO:0031163)3.53871113
70iron-sulfur cluster assembly (GO:0016226)3.53871113
71protein localization to endoplasmic reticulum (GO:0070972)3.53869601
72cellular protein complex disassembly (GO:0043624)3.53283145
73nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.52661461
74formation of translation preinitiation complex (GO:0001731)3.51664069
75transcription initiation from RNA polymerase I promoter (GO:0006361)3.48262236
76detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.47128232
77establishment of integrated proviral latency (GO:0075713)3.47051960
78viral life cycle (GO:0019058)3.42205363
79cellular component biogenesis (GO:0044085)3.40486312
80peptidyl-histidine modification (GO:0018202)3.39007805
81establishment of protein localization to mitochondrial membrane (GO:0090151)3.37843377
82DNA-templated transcription, termination (GO:0006353)3.34539113
83mitotic metaphase plate congression (GO:0007080)3.30036228
84tRNA modification (GO:0006400)3.28233337
85histone H4-K5 acetylation (GO:0043981)3.27062164
86histone H4-K8 acetylation (GO:0043982)3.27062164
87ribosome assembly (GO:0042255)3.26908036
88oxidative demethylation (GO:0070989)3.26493166
89DNA-dependent DNA replication (GO:0006261)3.20550933
90response to pheromone (GO:0019236)3.16924085
91negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16101051
92regulation of double-strand break repair via homologous recombination (GO:0010569)3.10433554
93viral mRNA export from host cell nucleus (GO:0046784)3.09698322
94cellular response to electrical stimulus (GO:0071257)3.07429352
95negative regulation of androgen receptor signaling pathway (GO:0060766)3.07248820
96regulation of mitochondrial translation (GO:0070129)3.06203704
97nucleobase biosynthetic process (GO:0046112)3.05382274
98protein complex disassembly (GO:0043241)3.03593157
99anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03234946
100cellular ketone body metabolic process (GO:0046950)3.03084050
101piRNA metabolic process (GO:0034587)3.03033424
102energy coupled proton transport, down electrochemical gradient (GO:0015985)3.02111548
103ATP synthesis coupled proton transport (GO:0015986)3.02111548
104fucosylation (GO:0036065)3.02052337
105axoneme assembly (GO:0035082)3.01796733
106positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01037050
107cilium movement (GO:0003341)3.00982618
108regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00751273
109DNA demethylation (GO:0080111)3.00403827
110DNA replication-independent nucleosome organization (GO:0034724)2.99451788
111DNA replication-independent nucleosome assembly (GO:0006336)2.99451788
112respiratory chain complex IV assembly (GO:0008535)2.98289188
113tongue development (GO:0043586)2.95013564
114purine nucleobase biosynthetic process (GO:0009113)2.94932705
115nonmotile primary cilium assembly (GO:0035058)2.94759581
116histone mRNA metabolic process (GO:0008334)2.94713562
117positive regulation of viral transcription (GO:0050434)2.94671537
118histone exchange (GO:0043486)2.94429262
119maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93201962
120tRNA processing (GO:0008033)2.93005327
121nucleotide-excision repair (GO:0006289)2.92633838
122single strand break repair (GO:0000012)2.92423606
123ncRNA processing (GO:0034470)2.92239596
124protein import into peroxisome matrix (GO:0016558)2.91855559
125neural tube formation (GO:0001841)2.91237341
126indolalkylamine metabolic process (GO:0006586)2.91127383
127macromolecular complex disassembly (GO:0032984)2.90901541
128ribonucleoside diphosphate metabolic process (GO:0009185)2.90553049
129replication fork processing (GO:0031297)2.90037301
130termination of RNA polymerase II transcription (GO:0006369)2.89833062
131nuclear-transcribed mRNA catabolic process (GO:0000956)2.89750344
132indole-containing compound catabolic process (GO:0042436)2.89638804
133indolalkylamine catabolic process (GO:0046218)2.89638804
134tryptophan catabolic process (GO:0006569)2.89638804
135cilium morphogenesis (GO:0060271)2.87787889
136mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86197664
137mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.85531347
138cytochrome complex assembly (GO:0017004)2.83883153
139recombinational repair (GO:0000725)2.81151896
140regulation of cilium movement (GO:0003352)2.80808495
141detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.80778381
142double-strand break repair via homologous recombination (GO:0000724)2.79953628
143negative regulation of telomere maintenance (GO:0032205)2.77725478
144seminiferous tubule development (GO:0072520)2.77358505
145sulfation (GO:0051923)2.76788015
146cilium or flagellum-dependent cell motility (GO:0001539)2.74533432
147base-excision repair, AP site formation (GO:0006285)2.71701905
148protein polyglutamylation (GO:0018095)2.70620923
149cornea development in camera-type eye (GO:0061303)2.70283408
150rRNA catabolic process (GO:0016075)2.69560054
151ketone body metabolic process (GO:1902224)2.68323147
152regulation of gene silencing by RNA (GO:0060966)2.66092080
153regulation of posttranscriptional gene silencing (GO:0060147)2.66092080
154regulation of gene silencing by miRNA (GO:0060964)2.66092080
155DNA methylation involved in gamete generation (GO:0043046)2.65850444
156platelet dense granule organization (GO:0060155)2.65601288
157intracellular protein transmembrane import (GO:0044743)2.63062571
158* preassembly of GPI anchor in ER membrane (GO:0016254)2.62602109
159negative regulation of translation, ncRNA-mediated (GO:0040033)2.61383391
160regulation of translation, ncRNA-mediated (GO:0045974)2.61383391
161negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61383391
162mannosylation (GO:0097502)2.59573079
163autophagic vacuole fusion (GO:0000046)2.57789211
164ubiquinone biosynthetic process (GO:0006744)2.57513890
165RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57050113
166tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57050113
167RNA modification (GO:0009451)2.56858990
168histone H3-K9 methylation (GO:0051567)2.55741865
169cilium organization (GO:0044782)2.55430257
170reciprocal DNA recombination (GO:0035825)2.54686692
171reciprocal meiotic recombination (GO:0007131)2.54686692
172L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54329352
173kynurenine metabolic process (GO:0070189)2.54058573
174mitochondrial RNA metabolic process (GO:0000959)2.53089996
175sperm motility (GO:0030317)2.51933093
176somatic hypermutation of immunoglobulin genes (GO:0016446)2.51528763
177somatic diversification of immune receptors via somatic mutation (GO:0002566)2.51528763
178organ growth (GO:0035265)2.49002144
179negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48979212
180tryptophan metabolic process (GO:0006568)2.48970325
181cilium assembly (GO:0042384)2.48807387
182DNA integration (GO:0015074)2.46542909
183somite development (GO:0061053)2.46519982
184cullin deneddylation (GO:0010388)2.45826232
185ubiquinone metabolic process (GO:0006743)2.44327035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.17198684
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.52965425
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.37787414
4VDR_22108803_ChIP-Seq_LS180_Human4.11217725
5ZNF274_21170338_ChIP-Seq_K562_Hela3.99515451
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.73177060
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.67537566
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.46120965
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.27025600
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.26586666
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21900977
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.08413832
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.04888832
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98466634
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92843006
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.87118250
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.86705276
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.85755383
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.80325422
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77100901
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74242645
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63941162
23IGF1R_20145208_ChIP-Seq_DFB_Human2.59224994
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.57000559
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48615545
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.35281754
27VDR_23849224_ChIP-Seq_CD4+_Human2.34462343
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.33880176
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.33880176
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.33880176
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27792807
32NANOG_18555785_ChIP-Seq_MESCs_Mouse2.26403182
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25653763
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.25304964
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.21111687
36* XRN2_22483619_ChIP-Seq_HELA_Human2.17556614
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16227915
38EWS_26573619_Chip-Seq_HEK293_Human2.13962935
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11766325
40FUS_26573619_Chip-Seq_HEK293_Human2.11766054
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10641983
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08365672
43TAF15_26573619_Chip-Seq_HEK293_Human2.04890655
44ELK1_19687146_ChIP-ChIP_HELA_Human2.02715549
45FOXM1_23109430_ChIP-Seq_U2OS_Human2.01743527
46ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00980378
47GBX2_23144817_ChIP-Seq_PC3_Human2.00906739
48* FOXP3_21729870_ChIP-Seq_TREG_Human2.00673059
49* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.99329943
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.98372628
51EZH2_22144423_ChIP-Seq_EOC_Human1.96268961
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96099245
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93973100
54TTF2_22483619_ChIP-Seq_HELA_Human1.89279220
55DCP1A_22483619_ChIP-Seq_HELA_Human1.88767013
56* SRF_21415370_ChIP-Seq_HL-1_Mouse1.88603439
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85125761
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82307319
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79703889
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76513336
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71421397
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69106439
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.66957646
64P300_19829295_ChIP-Seq_ESCs_Human1.66481465
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66385560
66TP53_22573176_ChIP-Seq_HFKS_Human1.65400738
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63950548
68ER_23166858_ChIP-Seq_MCF-7_Human1.58835019
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58344613
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58217779
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57532358
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.57526155
73GABP_19822575_ChIP-Seq_HepG2_Human1.56232852
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56065861
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.54432053
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53709423
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.52154789
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.50448027
79AR_21572438_ChIP-Seq_LNCaP_Human1.47605876
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46031437
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.45615163
82NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.42700160
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38258701
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.37117746
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36236723
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35726121
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35726121
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34618465
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34385997
90ELK1_22589737_ChIP-Seq_MCF10A_Human1.34119732
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33587106
92BCAT_22108803_ChIP-Seq_LS180_Human1.32017500
93E2F1_21310950_ChIP-Seq_MCF-7_Human1.31000808
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29873710
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26099654
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.26099654
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24227039
98IRF1_19129219_ChIP-ChIP_H3396_Human1.23900192
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23703583
100CBP_20019798_ChIP-Seq_JUKART_Human1.23703583
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23246151
102* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22971902
103GATA3_21878914_ChIP-Seq_MCF-7_Human1.22452353
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20336981
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19133822
106KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18094334
107RNF2_27304074_Chip-Seq_NSC_Mouse1.17826494
108STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17613314
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17495552
110NCOR_22424771_ChIP-Seq_293T_Human1.16484335
111PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16019332
112TP63_19390658_ChIP-ChIP_HaCaT_Human1.15941926
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.14430589
114SOX2_19829295_ChIP-Seq_ESCs_Human1.13886251
115NANOG_19829295_ChIP-Seq_ESCs_Human1.13886251
116AR_21909140_ChIP-Seq_LNCAP_Human1.13520847
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13384481
118HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13349319
119AR_20517297_ChIP-Seq_VCAP_Human1.10948154
120SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09540280
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08985862
122SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08413731
123FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07226716
124TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06759887
125CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06056233
126SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04129775
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.03827285
128AR_25329375_ChIP-Seq_VCAP_Human1.02986189
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02938899
130ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02768907
131TCF4_22108803_ChIP-Seq_LS180_Human1.02348818
132NANOG_21062744_ChIP-ChIP_HESCs_Human1.02340980
133GATA1_22025678_ChIP-Seq_K562_Human1.01696668
134OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01553268
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01028451
136STAT3_23295773_ChIP-Seq_U87_Human1.00519860
137BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00309403
138FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99183744
139CIITA_25753668_ChIP-Seq_RAJI_Human0.98073573
140EZH2_27294783_Chip-Seq_NPCs_Mouse0.97851976
141TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97760831
142* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97250247
143CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96089416
144* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95972354
145HOXB7_26014856_ChIP-Seq_BT474_Human0.95682561
146ERA_21632823_ChIP-Seq_H3396_Human0.95354015
147KDM5A_27292631_Chip-Seq_BREAST_Human0.95174337
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94793334
149NANOG_18692474_ChIP-Seq_MEFs_Mouse0.94778907
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.94075471
151POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93901902
152NANOG_20526341_ChIP-Seq_ESCs_Human0.93653273
153* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93385618
154TCF4_23295773_ChIP-Seq_U87_Human0.92487421
155EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92376725
156RUNX2_22187159_ChIP-Seq_PCA_Human0.92138289
157* NANOG_16153702_ChIP-ChIP_HESCs_Human0.91081165
158MYC_18940864_ChIP-ChIP_HL60_Human0.90965330
159KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89939192
160REST_21632747_ChIP-Seq_MESCs_Mouse0.89913948
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88631755
162OCT4_20526341_ChIP-Seq_ESCs_Human0.88425399
163* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87584520
164SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87422119
165POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.86559439
166ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86096147
167* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85688684
168CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83934451
169SOX17_20123909_ChIP-Seq_XEN_Mouse0.81453017
170* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81287563
171SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80414615
172SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.78432280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.18155372
2MP0005423_abnormal_somatic_nervous5.22658786
3MP0008057_abnormal_DNA_replication4.60760412
4MP0000566_synostosis4.23666071
5MP0003693_abnormal_embryo_hatching3.85567086
6MP0009379_abnormal_foot_pigmentation3.72884392
7MP0004145_abnormal_muscle_electrophysio3.67907659
8MP0003111_abnormal_nucleus_morphology3.53151930
9MP0008058_abnormal_DNA_repair3.16013374
10MP0003136_yellow_coat_color3.14645531
11MP0010094_abnormal_chromosome_stability3.05577976
12MP0004957_abnormal_blastocyst_morpholog2.90904752
13MP0003077_abnormal_cell_cycle2.74592539
14MP0006292_abnormal_olfactory_placode2.71370190
15MP0004133_heterotaxia2.44315878
16MP0008932_abnormal_embryonic_tissue2.24596023
17MP0002234_abnormal_pharynx_morphology2.14684332
18MP0005551_abnormal_eye_electrophysiolog2.14681272
19MP0003786_premature_aging2.14380964
20MP0003941_abnormal_skin_development2.11741015
21MP0008007_abnormal_cellular_replicative2.08662000
22MP0003718_maternal_effect2.05961811
23MP0005171_absent_coat_pigmentation1.97669217
24MP0001188_hyperpigmentation1.96904833
25MP0008875_abnormal_xenobiotic_pharmacok1.87492133
26MP0004381_abnormal_hair_follicle1.74086894
27MP0001984_abnormal_olfaction1.72791433
28MP0003195_calcinosis1.70534500
29MP0003806_abnormal_nucleotide_metabolis1.69729264
30MP0003045_fibrosis1.67094617
31MP0005646_abnormal_pituitary_gland1.66964950
32MP0008877_abnormal_DNA_methylation1.64582310
33MP0002132_abnormal_respiratory_system1.63415231
34MP0008872_abnormal_physiological_respon1.62515465
35MP0009046_muscle_twitch1.60676134
36MP0006276_abnormal_autonomic_nervous1.56535539
37MP0002876_abnormal_thyroid_physiology1.55136936
38MP0003646_muscle_fatigue1.55003554
39MP0002163_abnormal_gland_morphology1.50996814
40MP0004147_increased_porphyrin_level1.49368105
41MP0003011_delayed_dark_adaptation1.45746836
42MP0001968_abnormal_touch/_nociception1.43850554
43MP0000383_abnormal_hair_follicle1.43753870
44MP0005645_abnormal_hypothalamus_physiol1.40524836
45MP0003787_abnormal_imprinting1.39868035
46MP0003123_paternal_imprinting1.39129360
47MP0000631_abnormal_neuroendocrine_gland1.36060619
48MP0002837_dystrophic_cardiac_calcinosis1.35822217
49MP0009745_abnormal_behavioral_response1.33810752
50MP0002736_abnormal_nociception_after1.33617557
51MP0005410_abnormal_fertilization1.27972016
52MP0002210_abnormal_sex_determination1.27280520
53MP0003937_abnormal_limbs/digits/tail_de1.27070839
54MP0001764_abnormal_homeostasis1.26959714
55MP0002272_abnormal_nervous_system1.25287263
56MP0000372_irregular_coat_pigmentation1.22857958
57MP0000569_abnormal_digit_pigmentation1.22251091
58MP0003283_abnormal_digestive_organ1.21203131
59MP0002277_abnormal_respiratory_mucosa1.19432799
60MP0004043_abnormal_pH_regulation1.18586569
61MP0008961_abnormal_basal_metabolism1.18287337
62MP0003890_abnormal_embryonic-extraembry1.18206384
63MP0001501_abnormal_sleep_pattern1.16687633
64MP0000762_abnormal_tongue_morphology1.16507835
65MP0005395_other_phenotype1.16482568
66MP0000350_abnormal_cell_proliferation1.11897985
67MP0005389_reproductive_system_phenotype1.10328811
68MP0003186_abnormal_redox_activity1.09993331
69MP0001529_abnormal_vocalization1.09421602
70MP0002928_abnormal_bile_duct1.09286848
71MP0003880_abnormal_central_pattern1.08070678
72MP0008995_early_reproductive_senescence1.07771168
73MP0002160_abnormal_reproductive_system1.07748664
74MP0005075_abnormal_melanosome_morpholog1.06107231
75MP0010386_abnormal_urinary_bladder1.05995192
76MP0002735_abnormal_chemical_nociception1.05480267
77MP0000427_abnormal_hair_cycle1.04790787
78MP0001919_abnormal_reproductive_system1.02981517
79MP0005195_abnormal_posterior_eye1.01021982
80MP0001145_abnormal_male_reproductive1.00888877
81MP0010030_abnormal_orbit_morphology1.00841469
82MP0003122_maternal_imprinting0.98537308
83MP0001502_abnormal_circadian_rhythm0.98324633
84MP0005379_endocrine/exocrine_gland_phen0.97065613
85MP0001486_abnormal_startle_reflex0.95796737
86MP0005174_abnormal_tail_pigmentation0.95346588
87MP0001730_embryonic_growth_arrest0.95041353
88MP0005408_hypopigmentation0.94405309
89MP0002752_abnormal_somatic_nervous0.94380696
90MP0002751_abnormal_autonomic_nervous0.94264974
91MP0000026_abnormal_inner_ear0.93641422
92MP0005253_abnormal_eye_physiology0.92963954
93MP0003119_abnormal_digestive_system0.92938419
94MP0005084_abnormal_gallbladder_morpholo0.92835437
95MP0004742_abnormal_vestibular_system0.92686305
96MP0002557_abnormal_social/conspecific_i0.91890014
97MP0002822_catalepsy0.91056982
98MP0005409_darkened_coat_color0.89934079
99MP0002184_abnormal_innervation0.89629214
100MP0000313_abnormal_cell_death0.89568637
101MP0000653_abnormal_sex_gland0.89309432
102MP0004885_abnormal_endolymph0.88993406
103MP0002938_white_spotting0.88819049
104MP0002085_abnormal_embryonic_tissue0.88257546
105MP0001905_abnormal_dopamine_level0.87344608
106MP0001929_abnormal_gametogenesis0.86690477
107MP0001664_abnormal_digestion0.86347060
108MP0002572_abnormal_emotion/affect_behav0.85915109
109MP0003315_abnormal_perineum_morphology0.84609101
110MP0006072_abnormal_retinal_apoptosis0.82724591
111MP0001286_abnormal_eye_development0.80582265
112MP0001324_abnormal_eye_pigmentation0.80246855
113MP0005332_abnormal_amino_acid0.79124945
114MP0002067_abnormal_sensory_capabilities0.78406405
115MP0001186_pigmentation_phenotype0.77820307
116MP0008789_abnormal_olfactory_epithelium0.77429774
117MP0006035_abnormal_mitochondrial_morpho0.75911406
118MP0001293_anophthalmia0.75512865
119MP0001963_abnormal_hearing_physiology0.74891309
120MP0001663_abnormal_digestive_system0.74798328
121MP0004142_abnormal_muscle_tone0.74440819
122MP0003950_abnormal_plasma_membrane0.73532486
123MP0001672_abnormal_embryogenesis/_devel0.73221656
124MP0005380_embryogenesis_phenotype0.73221656
125MP0001485_abnormal_pinna_reflex0.73166698
126MP0002095_abnormal_skin_pigmentation0.72951201
127MP0003121_genomic_imprinting0.71447808
128MP0001697_abnormal_embryo_size0.69323072
129MP0001119_abnormal_female_reproductive0.68360820
130MP0002638_abnormal_pupillary_reflex0.68070786
131MP0002080_prenatal_lethality0.67664650
132MP0002102_abnormal_ear_morphology0.67527515
133MP0003755_abnormal_palate_morphology0.66273058
134MP0000015_abnormal_ear_pigmentation0.65409938
135MP0005266_abnormal_metabolism0.62292504
136MP0000049_abnormal_middle_ear0.61560003
137MP0000490_abnormal_crypts_of0.61516952
138MP0002019_abnormal_tumor_incidence0.61145199
139MP0002653_abnormal_ependyma_morphology0.60965094
140MP0003938_abnormal_ear_development0.60472635
141MP0005391_vision/eye_phenotype0.59317409
142MP0002168_other_aberrant_phenotype0.57820772
143MP0003698_abnormal_male_reproductive0.56374142
144MP0002084_abnormal_developmental_patter0.56096884
145MP0002111_abnormal_tail_morphology0.56067208
146MP0006036_abnormal_mitochondrial_physio0.55875329
147MP0004197_abnormal_fetal_growth/weight/0.55784158
148MP0003984_embryonic_growth_retardation0.53209483
149MP0002086_abnormal_extraembryonic_tissu0.52425138
150MP0002075_abnormal_coat/hair_pigmentati0.52396918
151MP0005499_abnormal_olfactory_system0.51057551
152MP0005394_taste/olfaction_phenotype0.51057551
153MP0009697_abnormal_copulation0.51037747
154MP0002088_abnormal_embryonic_growth/wei0.49938650
155MP0003936_abnormal_reproductive_system0.48708829

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)5.59986864
2Muscle abnormality related to mitochondrial dysfunction (HP:0003800)5.10041297
3Reticulocytopenia (HP:0001896)4.67452947
4Congenital stationary night blindness (HP:0007642)4.49905922
5Pancreatic cysts (HP:0001737)4.38082586
6Birth length less than 3rd percentile (HP:0003561)4.32118583
7Abnormality of midbrain morphology (HP:0002418)4.13469524
8Molar tooth sign on MRI (HP:0002419)4.13469524
9Decreased activity of mitochondrial respiratory chain (HP:0008972)4.07140737
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.07140737
11Pancreatic fibrosis (HP:0100732)3.92906178
12True hermaphroditism (HP:0010459)3.76960060
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.72858366
14Abnormality of cells of the erythroid lineage (HP:0012130)3.62332616
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.54031559
16Chromsome breakage (HP:0040012)3.51926487
17Progressive external ophthalmoplegia (HP:0000590)3.43505802
18Macrocytic anemia (HP:0001972)3.41106562
19Absent radius (HP:0003974)3.36595030
20Medial flaring of the eyebrow (HP:0010747)3.34921906
21Abnormal number of erythroid precursors (HP:0012131)3.34381263
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.33099331
23Nephronophthisis (HP:0000090)3.26835297
24Absent forearm bone (HP:0003953)3.21911988
25Aplasia involving forearm bones (HP:0009822)3.21911988
26Increased intramyocellular lipid droplets (HP:0012240)3.20487624
27Carpal bone hypoplasia (HP:0001498)3.00489424
28Rough bone trabeculation (HP:0100670)2.99096468
29Pallor (HP:0000980)2.97804321
30Patellar aplasia (HP:0006443)2.91818294
31Cystic liver disease (HP:0006706)2.87193454
32Cerebral hypomyelination (HP:0006808)2.85353909
33Acute necrotizing encephalopathy (HP:0006965)2.80040804
34Chronic hepatic failure (HP:0100626)2.79395068
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.75348934
36Congenital primary aphakia (HP:0007707)2.75316217
37Gait imbalance (HP:0002141)2.72249397
38Methylmalonic acidemia (HP:0002912)2.71951067
39Aplasia/Hypoplasia of the patella (HP:0006498)2.70616699
40Abnormality of the renal medulla (HP:0100957)2.68739327
41Absent thumb (HP:0009777)2.66708823
42Abnormality of the labia minora (HP:0012880)2.66437234
43Premature graying of hair (HP:0002216)2.63677878
44Oral leukoplakia (HP:0002745)2.63334035
45Abnormality of the ileum (HP:0001549)2.62253891
46Aplasia/Hypoplasia involving the musculature (HP:0001460)2.61737769
47Meckel diverticulum (HP:0002245)2.61385129
483-Methylglutaconic aciduria (HP:0003535)2.61325379
49Pendular nystagmus (HP:0012043)2.58836815
50Type II lissencephaly (HP:0007260)2.58141163
51Abnormality of alanine metabolism (HP:0010916)2.57773020
52Hyperalaninemia (HP:0003348)2.57773020
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.57773020
54Abnormality of the preputium (HP:0100587)2.57382174
55Increased serum lactate (HP:0002151)2.54408512
56Aplastic anemia (HP:0001915)2.54405646
57Supernumerary spleens (HP:0009799)2.53160710
58Nephrogenic diabetes insipidus (HP:0009806)2.52789734
59Renal Fanconi syndrome (HP:0001994)2.52241543
60Exercise intolerance (HP:0003546)2.51759681
61Aplasia of the musculature (HP:0100854)2.48238343
62Increased hepatocellular lipid droplets (HP:0006565)2.46972305
63* Duplicated collecting system (HP:0000081)2.45839185
64Attenuation of retinal blood vessels (HP:0007843)2.45510092
65Methylmalonic aciduria (HP:0012120)2.44741898
66Increased muscle lipid content (HP:0009058)2.42800056
67Exertional dyspnea (HP:0002875)2.40460610
68Abnormality of the renal cortex (HP:0011035)2.38617170
69Mitochondrial inheritance (HP:0001427)2.38168523
70Abnormal rod and cone electroretinograms (HP:0008323)2.36678014
71Triphalangeal thumb (HP:0001199)2.34498008
72Abnormal trabecular bone morphology (HP:0100671)2.34402329
73Abnormality of chromosome stability (HP:0003220)2.33523279
74Abnormal biliary tract physiology (HP:0012439)2.33399760
75Bile duct proliferation (HP:0001408)2.33399760
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.33009965
77Absent/shortened dynein arms (HP:0200106)2.33009965
78Hypoplasia of the pons (HP:0012110)2.32243357
79Abnormal mitochondria in muscle tissue (HP:0008316)2.29838437
80* Abnormality of the renal collecting system (HP:0004742)2.29454171
81Aplasia/Hypoplasia of the uvula (HP:0010293)2.29382899
82Abnormality of the pons (HP:0007361)2.28933806
83Colon cancer (HP:0003003)2.28346893
84Conical tooth (HP:0000698)2.27358580
85Sclerocornea (HP:0000647)2.25801677
86Concave nail (HP:0001598)2.25557156
87Genetic anticipation (HP:0003743)2.25421561
88Abolished electroretinogram (ERG) (HP:0000550)2.24743895
89Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23822537
90Increased IgM level (HP:0003496)2.23355671
9111 pairs of ribs (HP:0000878)2.23300635
92Horseshoe kidney (HP:0000085)2.21602153
93Progressive cerebellar ataxia (HP:0002073)2.21334088
94Hyperglycinemia (HP:0002154)2.19943533
95Anencephaly (HP:0002323)2.19484731
96Rectal fistula (HP:0100590)2.17289003
97Rectovaginal fistula (HP:0000143)2.17289003
98Progressive muscle weakness (HP:0003323)2.15063708
99Genital tract atresia (HP:0001827)2.14204173
100Sparse eyelashes (HP:0000653)2.12656340
101Bone marrow hypocellularity (HP:0005528)2.12213882
102Vaginal atresia (HP:0000148)2.12163171
103Aplasia/Hypoplasia of the earlobes (HP:0009906)2.10729231
104Acute encephalopathy (HP:0006846)2.10176250
105Increased CSF lactate (HP:0002490)2.10053987
106Poor coordination (HP:0002370)2.09405394
107Male pseudohermaphroditism (HP:0000037)2.09203862
108Renal cortical cysts (HP:0000803)2.07967114
109Optic disc pallor (HP:0000543)2.07667656
110Aplasia/Hypoplasia of the tongue (HP:0010295)2.06643360
111Progressive macrocephaly (HP:0004481)2.06638373
112Severe muscular hypotonia (HP:0006829)2.06621535
113Cerebellar dysplasia (HP:0007033)2.05490804
114Abnormality of abdominal situs (HP:0011620)2.05452570
115Abdominal situs inversus (HP:0003363)2.05452570
116Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.05145616
117Abnormality of placental membranes (HP:0011409)2.02928476
118Amniotic constriction ring (HP:0009775)2.02928476
119Hepatic necrosis (HP:0002605)2.02607601
120Hypothermia (HP:0002045)2.02342358
121Absent hand (HP:0004050)2.02113421
122Abnormal respiratory epithelium morphology (HP:0012253)2.01925953
123Abnormal respiratory motile cilium morphology (HP:0005938)2.01925953
124Hypoplasia of the radius (HP:0002984)2.01075650
125Abnormality of secondary sexual hair (HP:0009888)2.01066099
126Abnormality of the axillary hair (HP:0100134)2.01066099
127Congenital hepatic fibrosis (HP:0002612)2.00847322
128Selective tooth agenesis (HP:0001592)2.00688740
129Hyperventilation (HP:0002883)1.98677670
130Abnormal hemoglobin (HP:0011902)1.98007109
131Brushfield spots (HP:0001088)1.97874063
132External ophthalmoplegia (HP:0000544)1.97202112
133Lactic acidosis (HP:0003128)1.96377058
134Hepatocellular necrosis (HP:0001404)1.96189638
135Septo-optic dysplasia (HP:0100842)1.96173427
136Adrenal hypoplasia (HP:0000835)1.95880573
137Postaxial foot polydactyly (HP:0001830)1.95659309
138Type 2 muscle fiber atrophy (HP:0003554)1.95343325
139Polydipsia (HP:0001959)1.94746089
140Abnormal drinking behavior (HP:0030082)1.94746089
141Rib fusion (HP:0000902)1.94471695
142Pancytopenia (HP:0001876)1.94469148
143Granulocytopenia (HP:0001913)1.94402140
144Myelodysplasia (HP:0002863)1.93296875
145Supernumerary bones of the axial skeleton (HP:0009144)1.92754826
146Occipital encephalocele (HP:0002085)1.92752218
147Breast aplasia (HP:0100783)1.92614775
148Lipid accumulation in hepatocytes (HP:0006561)1.92285925
149Aplasia/Hypoplasia of the breasts (HP:0010311)1.91879969
150Impulsivity (HP:0100710)1.91546923
151Gaze-evoked nystagmus (HP:0000640)1.91379721
152Tubular atrophy (HP:0000092)1.90813221
153Cerebral edema (HP:0002181)1.88717980
154Aplasia/Hypoplasia of the tibia (HP:0005772)1.88679533
155Cleft eyelid (HP:0000625)1.88336019
156Abnormal number of incisors (HP:0011064)1.87279979
157Congenital, generalized hypertrichosis (HP:0004540)1.87079049
158Duplication of thumb phalanx (HP:0009942)1.87031762
159Muscle fiber atrophy (HP:0100295)1.86929998
160Microvesicular hepatic steatosis (HP:0001414)1.86636938
161Furrowed tongue (HP:0000221)1.85464245
162Type I transferrin isoform profile (HP:0003642)1.85010884
163Homocystinuria (HP:0002156)1.83809685
164Abnormality of homocysteine metabolism (HP:0010919)1.83809685
165Preaxial hand polydactyly (HP:0001177)1.80029484
166Lissencephaly (HP:0001339)1.78766356
167Constricted visual fields (HP:0001133)1.77574346
168Inability to walk (HP:0002540)1.77146676
169Hyperglycinuria (HP:0003108)1.76363379
170Ketosis (HP:0001946)1.76205371
171Postaxial hand polydactyly (HP:0001162)1.74269583
172Dandy-Walker malformation (HP:0001305)1.73068981
173Abnormal ciliary motility (HP:0012262)1.71627739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.30120498
2FRK3.99450884
3IRAK33.98433488
4CDC42BPA3.56044586
5STK163.47818405
6MAP4K23.32350980
7WEE12.96855452
8PLK42.92233808
9ZAK2.76968389
10SRPK12.68210683
11BCKDK2.65663386
12EIF2AK12.39508792
13VRK12.35371340
14TAOK32.21644468
15NME22.19917901
16EPHA22.17521549
17IRAK42.16312590
18WNK42.15389125
19NUAK12.14323003
20EIF2AK32.03057214
21WNK32.02899304
22AKT31.96124236
23TTK1.94533697
24DYRK31.76961498
25MAPK131.65625540
26IRAK21.63188326
27PLK11.60957868
28CDC71.58882516
29INSRR1.56163666
30MAP3K41.50759230
31MKNK21.48256355
32TLK11.46991615
33MARK11.41731368
34ATR1.39225326
35MKNK11.39010812
36CDK71.34049048
37TESK21.33029006
38PLK31.31485557
39MST41.29590049
40RPS6KB21.28874792
41PBK1.24502526
42EIF2AK21.23529137
43IRAK11.22434443
44YES11.21835226
45ROCK21.21621307
46PIM21.21302766
47NME11.17544094
48CHEK21.15583890
49VRK21.14156309
50NEK61.12386968
51OXSR11.10525988
52DYRK21.10055311
53TAOK11.08174330
54PIK3CA1.07662370
55AURKA1.05111621
56MAP2K71.04401781
57PAK41.01720189
58TGFBR10.96029517
59BRSK20.94107975
60TSSK60.93599982
61CASK0.93245216
62PRKCI0.90682288
63STK390.90241685
64AURKB0.89924836
65ACVR1B0.84007140
66ABL20.83373049
67BRD40.81748693
68CHEK10.81513018
69BRAF0.81288201
70DAPK20.80919101
71STK38L0.80592396
72DYRK1A0.80117133
73ADRBK10.79855933
74CLK10.73607817
75CSNK2A10.72980372
76KIT0.72588043
77IKBKB0.71882790
78TNIK0.70085723
79CSNK2A20.67111076
80ADRBK20.66037768
81PRKCG0.65939407
82TRIM280.65864710
83PAK30.65456647
84TAF10.64939097
85MAP2K30.64173848
86TEC0.64113916
87PINK10.62842505
88CAMKK20.62458940
89MAP3K80.61659851
90ATM0.61656672
91BMPR20.60376526
92PRKD20.59123154
93MAPK150.58052952
94PRKCQ0.57484278
95CSNK1A1L0.55441249
96CDK190.55147194
97PIM10.54267538
98NEK10.53991376
99ROCK10.53414773
100PNCK0.53247284
101CDK20.52837694
102MAPKAPK50.52520782
103MAP3K110.52172180
104CSNK1G30.51456155
105CCNB10.50769016
106FLT30.50170987
107TAOK20.49088992
108ERBB30.48782497
109PASK0.48705166
110FGFR20.48016676
111PAK10.47071183
112PRKCE0.46693861
113TXK0.46604633
114MAP2K40.46454331
115MAP3K120.46177008
116NLK0.45954454
117CDK10.45802285
118CSNK1A10.45292777
119CSNK1G10.44643855
120BRSK10.44635634
121EPHA40.43359293
122RPS6KA50.43180150
123CDK80.42655453
124PHKG10.42104746
125PHKG20.42104746
126CHUK0.39822392
127CSNK1G20.39668362
128PRKCD0.39473669
129MARK30.39164377
130GRK70.38992837
131STK110.38292301
132MAP2K60.37180838
133NEK20.36580277
134GRK50.36210256
135ITK0.35304184
136MAP3K50.35075965
137STK40.34711270
138BCR0.34538375
139MAPKAPK30.33278203
140TIE10.33072977
141DAPK10.32919700
142PRKACA0.32829869
143JAK30.32654014
144TNK20.31742622
145BMPR1B0.31518371
146GRK10.29945116
147OBSCN0.28941483
148LYN0.28788669
149LATS20.28179738
150CAMK2B0.27653289
151CDK30.27204219
152MATK0.26897339
153ARAF0.26842627
154PRKG10.26620278
155PDK20.26288678
156SIK30.24711267
157CSNK1E0.24420540
158MAPK70.21483919
159CDK40.17314886

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.98388054
2RNA polymerase_Homo sapiens_hsa030204.29427909
3DNA replication_Homo sapiens_hsa030304.21481436
4Mismatch repair_Homo sapiens_hsa034304.08208390
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53556757
6Proteasome_Homo sapiens_hsa030503.47139931
7Fanconi anemia pathway_Homo sapiens_hsa034603.22073625
8Spliceosome_Homo sapiens_hsa030403.14459321
9Pyrimidine metabolism_Homo sapiens_hsa002403.01488481
10Nucleotide excision repair_Homo sapiens_hsa034202.83965618
11Homologous recombination_Homo sapiens_hsa034402.82204205
12Base excision repair_Homo sapiens_hsa034102.64631938
13RNA transport_Homo sapiens_hsa030132.46366742
14Oxidative phosphorylation_Homo sapiens_hsa001902.30042239
15One carbon pool by folate_Homo sapiens_hsa006702.05797812
16Butanoate metabolism_Homo sapiens_hsa006502.03744497
17Basal transcription factors_Homo sapiens_hsa030222.01019618
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00435450
19Parkinsons disease_Homo sapiens_hsa050121.92774823
20Huntingtons disease_Homo sapiens_hsa050161.81597163
21Nitrogen metabolism_Homo sapiens_hsa009101.81334281
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80560411
23Purine metabolism_Homo sapiens_hsa002301.78883946
24RNA degradation_Homo sapiens_hsa030181.77760011
25Selenocompound metabolism_Homo sapiens_hsa004501.74375398
26Cell cycle_Homo sapiens_hsa041101.73611208
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.67623649
28Protein export_Homo sapiens_hsa030601.64866543
29Propanoate metabolism_Homo sapiens_hsa006401.63408041
30Non-homologous end-joining_Homo sapiens_hsa034501.61594052
31Phototransduction_Homo sapiens_hsa047441.60530051
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59879556
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50768091
34Taste transduction_Homo sapiens_hsa047421.49193919
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45547173
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38899712
37Peroxisome_Homo sapiens_hsa041461.30398173
38Caffeine metabolism_Homo sapiens_hsa002321.30348043
39Tryptophan metabolism_Homo sapiens_hsa003801.28171512
40Epstein-Barr virus infection_Homo sapiens_hsa051691.21971040
41Alzheimers disease_Homo sapiens_hsa050101.20912167
42p53 signaling pathway_Homo sapiens_hsa041151.20281172
43mRNA surveillance pathway_Homo sapiens_hsa030151.19646064
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19530488
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12417597
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11378995
47Olfactory transduction_Homo sapiens_hsa047401.08953728
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06569629
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01651445
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.98498442
51* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92824926
52Glutathione metabolism_Homo sapiens_hsa004800.87307762
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.85462318
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85439975
55ABC transporters_Homo sapiens_hsa020100.81853738
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79544532
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79261497
58Arachidonic acid metabolism_Homo sapiens_hsa005900.77823775
59Folate biosynthesis_Homo sapiens_hsa007900.77707549
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75361471
61Fat digestion and absorption_Homo sapiens_hsa049750.72426815
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69344001
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68816126
64Glycerolipid metabolism_Homo sapiens_hsa005610.68724164
65Vitamin digestion and absorption_Homo sapiens_hsa049770.67990684
66Serotonergic synapse_Homo sapiens_hsa047260.67746808
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.66058932
68beta-Alanine metabolism_Homo sapiens_hsa004100.64958101
69Arginine and proline metabolism_Homo sapiens_hsa003300.63808070
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61947956
71Morphine addiction_Homo sapiens_hsa050320.59676934
72GABAergic synapse_Homo sapiens_hsa047270.54007099
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.53494419
74Systemic lupus erythematosus_Homo sapiens_hsa053220.52034497
75Vitamin B6 metabolism_Homo sapiens_hsa007500.51840978
76* Metabolic pathways_Homo sapiens_hsa011000.50759651
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49111116
78Lysine degradation_Homo sapiens_hsa003100.46257049
79Cardiac muscle contraction_Homo sapiens_hsa042600.45203642
80Circadian entrainment_Homo sapiens_hsa047130.44260258
81Herpes simplex infection_Homo sapiens_hsa051680.41218776
82Calcium signaling pathway_Homo sapiens_hsa040200.40353644
83Histidine metabolism_Homo sapiens_hsa003400.39257557
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.38889370
85Ether lipid metabolism_Homo sapiens_hsa005650.38494619
86Oocyte meiosis_Homo sapiens_hsa041140.38430579
87Notch signaling pathway_Homo sapiens_hsa043300.37237654
88Linoleic acid metabolism_Homo sapiens_hsa005910.36992760
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36582822
90Fatty acid degradation_Homo sapiens_hsa000710.36562827
91Primary immunodeficiency_Homo sapiens_hsa053400.36022197
92Sulfur metabolism_Homo sapiens_hsa009200.35530841
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.34916486
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34589325
95Insulin secretion_Homo sapiens_hsa049110.33714308
96Circadian rhythm_Homo sapiens_hsa047100.33541186
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.33520520
98Salivary secretion_Homo sapiens_hsa049700.32287193
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31541258
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31044915
101Ovarian steroidogenesis_Homo sapiens_hsa049130.30934748
102Autoimmune thyroid disease_Homo sapiens_hsa053200.30206542
103Fatty acid elongation_Homo sapiens_hsa000620.29613565
104Viral carcinogenesis_Homo sapiens_hsa052030.29247929
105Renin-angiotensin system_Homo sapiens_hsa046140.28541018
106Regulation of autophagy_Homo sapiens_hsa041400.25759266
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25508730
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25157097
109Other glycan degradation_Homo sapiens_hsa005110.23714644
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23448965
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21310965
112Graft-versus-host disease_Homo sapiens_hsa053320.19632415
113HTLV-I infection_Homo sapiens_hsa051660.19269138
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18392356
115Biosynthesis of amino acids_Homo sapiens_hsa012300.16638518
116Allograft rejection_Homo sapiens_hsa053300.16152860
117Pentose phosphate pathway_Homo sapiens_hsa000300.15474867
118Fructose and mannose metabolism_Homo sapiens_hsa000510.15299609
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14903334
120Basal cell carcinoma_Homo sapiens_hsa052170.14124168
121Sulfur relay system_Homo sapiens_hsa041220.14060806
122Steroid biosynthesis_Homo sapiens_hsa001000.12944394
123Sphingolipid metabolism_Homo sapiens_hsa006000.12583061
124Shigellosis_Homo sapiens_hsa051310.12242552
125Collecting duct acid secretion_Homo sapiens_hsa049660.12182884
126Tyrosine metabolism_Homo sapiens_hsa003500.12046301
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11582162
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11013611
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.11003839
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.10513935
131Hematopoietic cell lineage_Homo sapiens_hsa046400.08775795
132Chemical carcinogenesis_Homo sapiens_hsa052040.08761437
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08120828
134Apoptosis_Homo sapiens_hsa042100.07678281
135Hedgehog signaling pathway_Homo sapiens_hsa043400.06931970
136Wnt signaling pathway_Homo sapiens_hsa043100.06740525
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.06354037
138NOD-like receptor signaling pathway_Homo sapiens_hsa046210.05396314
139Nicotine addiction_Homo sapiens_hsa050330.05151248
140Retinol metabolism_Homo sapiens_hsa008300.04872134
141TGF-beta signaling pathway_Homo sapiens_hsa043500.04864705
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.02315853

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