PIGCP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to lipoprotein particle (GO:0055094)6.79507251
2pyrimidine nucleobase catabolic process (GO:0006208)5.32718922
3positive regulation of cell size (GO:0045793)4.62627245
4negative regulation of neurotransmitter transport (GO:0051589)4.51482064
5nucleobase catabolic process (GO:0046113)4.45381153
6regulation of synaptic vesicle exocytosis (GO:2000300)3.93589970
7microtubule nucleation (GO:0007020)3.89962739
8synaptic vesicle docking involved in exocytosis (GO:0016081)3.77944451
9regulation of short-term neuronal synaptic plasticity (GO:0048172)3.74611197
10positive regulation of oligodendrocyte differentiation (GO:0048714)3.74385170
11axonal fasciculation (GO:0007413)3.72508776
12positive regulation of catecholamine secretion (GO:0033605)3.72503280
13regulation of synaptic vesicle transport (GO:1902803)3.64550506
14nerve growth factor signaling pathway (GO:0038180)3.62779293
15regulation of plasminogen activation (GO:0010755)3.52421146
16glutamate secretion (GO:0014047)3.48628268
17cellular protein complex localization (GO:0034629)3.46510752
18protein localization to synapse (GO:0035418)3.42872109
19presynaptic membrane assembly (GO:0097105)3.40934654
20cell wall macromolecule metabolic process (GO:0044036)3.33394598
21presynaptic membrane organization (GO:0097090)3.32050563
22synaptic vesicle maturation (GO:0016188)3.31934941
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.25399077
24layer formation in cerebral cortex (GO:0021819)3.25329486
25neuron recognition (GO:0008038)3.24530027
26negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.21898622
27positive regulation of dendritic spine morphogenesis (GO:0061003)3.20175417
28postsynaptic membrane organization (GO:0001941)3.07328289
29behavioral defense response (GO:0002209)3.01850590
30behavioral fear response (GO:0001662)3.01850590
31skeletal muscle organ development (GO:0060538)3.00594597
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.00284104
33negative regulation of neurotransmitter secretion (GO:0046929)2.99993364
34cartilage morphogenesis (GO:0060536)2.99376761
35negative regulation of keratinocyte proliferation (GO:0010839)2.97143711
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.96437640
37synaptic vesicle exocytosis (GO:0016079)2.96412413
38positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.88810087
39establishment of mitochondrion localization (GO:0051654)2.87099733
40neurotransmitter-gated ion channel clustering (GO:0072578)2.81653326
41cell wall macromolecule catabolic process (GO:0016998)2.80072726
42innervation (GO:0060384)2.79527525
43cellular response to hepatocyte growth factor stimulus (GO:0035729)2.79070310
44response to hepatocyte growth factor (GO:0035728)2.79070310
45epithelial cell differentiation involved in kidney development (GO:0035850)2.78106762
46negative regulation of cell size (GO:0045792)2.76011778
47regulation of glutamate receptor signaling pathway (GO:1900449)2.75784462
48negative regulation of axon guidance (GO:1902668)2.75730417
49organelle transport along microtubule (GO:0072384)2.74845947
50dendritic spine morphogenesis (GO:0060997)2.73328195
51homocysteine metabolic process (GO:0050667)2.72340056
52neurotransmitter secretion (GO:0007269)2.71777050
53regulation of axon guidance (GO:1902667)2.71526523
54histone H3-K4 methylation (GO:0051568)2.71395155
55peptidyl-cysteine modification (GO:0018198)2.69986691
56protein targeting to vacuole (GO:0006623)2.68519437
57protein targeting to lysosome (GO:0006622)2.68519437
58establishment of protein localization to vacuole (GO:0072666)2.68519437
59positive regulation of endothelial cell differentiation (GO:0045603)2.67482096
60diaphragm development (GO:0060539)2.62789811
61positive regulation of dendritic spine development (GO:0060999)2.62189501
62regulation of oligodendrocyte differentiation (GO:0048713)2.62147081
63glial cell proliferation (GO:0014009)2.60240748
64long-term synaptic potentiation (GO:0060291)2.59760162
65central nervous system projection neuron axonogenesis (GO:0021952)2.59209260
66endoplasmic reticulum organization (GO:0007029)2.58283094
67desmosome organization (GO:0002934)2.55856046
68retrograde transport, vesicle recycling within Golgi (GO:0000301)2.55604135
69regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.54880528
70gamma-aminobutyric acid signaling pathway (GO:0007214)2.52466765
71response to parathyroid hormone (GO:0071107)2.52189565
72neuron projection extension involved in neuron projection guidance (GO:1902284)2.51876771
73axon extension involved in axon guidance (GO:0048846)2.51876771
74positive regulation of macroautophagy (GO:0016239)2.50835985
75vocalization behavior (GO:0071625)2.49078388
76gamma-aminobutyric acid transport (GO:0015812)2.48813514
77regulation of neuronal synaptic plasticity (GO:0048168)2.48364842
78phosphorelay signal transduction system (GO:0000160)2.47511150
79regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.47051347
80cellular response to vitamin D (GO:0071305)2.46122855
81negative regulation of calcium ion transport into cytosol (GO:0010523)2.45126765
82negative regulation of vascular permeability (GO:0043116)2.44885405
83regulation of glycogen (starch) synthase activity (GO:2000465)2.44648599
84protein import into peroxisome matrix (GO:0016558)2.44604758
85negative regulation of microtubule polymerization (GO:0031115)2.44572286
86fear response (GO:0042596)2.44398279
87central nervous system neuron axonogenesis (GO:0021955)2.44390726
88cellular response to nerve growth factor stimulus (GO:1990090)2.42768626
89response to nerve growth factor (GO:1990089)2.42768626
90regulation of synapse assembly (GO:0051963)2.41110322
91establishment of synaptic vesicle localization (GO:0097480)2.39539706
92synaptic vesicle transport (GO:0048489)2.39539706
93regulation of feeding behavior (GO:0060259)2.39025791
94neuron cell-cell adhesion (GO:0007158)2.39002716
95positive regulation of dendrite morphogenesis (GO:0050775)2.38132147
96positive regulation of fibroblast migration (GO:0010763)2.37885023
97establishment of protein localization to Golgi (GO:0072600)2.35623999
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.35546131
99spermatid nucleus differentiation (GO:0007289)2.35408635
100vesicle docking involved in exocytosis (GO:0006904)2.35295832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.73853713
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.66459038
3IGF1R_20145208_ChIP-Seq_DFB_Human3.34760664
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.14779415
5SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.61019109
6GBX2_23144817_ChIP-Seq_PC3_Human2.58259921
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.57182886
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37959963
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32668357
10TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse2.32541641
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.29360086
12FUS_26573619_Chip-Seq_HEK293_Human2.26886411
13REST_21632747_ChIP-Seq_MESCs_Mouse2.24974385
14AR_21572438_ChIP-Seq_LNCaP_Human2.21636438
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.17470416
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.16927416
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03675201
18TP53_16413492_ChIP-PET_HCT116_Human1.95639969
19TAF15_26573619_Chip-Seq_HEK293_Human1.94990159
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93378610
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86057505
22NR3C1_21868756_ChIP-Seq_MCF10A_Human1.85587640
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85148238
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81886262
25STAT3_23295773_ChIP-Seq_U87_Human1.80519293
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.79955430
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.71224720
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68678548
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68042954
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66878454
31SMAD4_21799915_ChIP-Seq_A2780_Human1.66607726
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.66599812
33ZNF274_21170338_ChIP-Seq_K562_Hela1.61503342
34AHR_22903824_ChIP-Seq_MCF-7_Human1.61107887
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57844083
36P300_19829295_ChIP-Seq_ESCs_Human1.57256613
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54300522
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53754690
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52217135
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49197718
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48127644
42TCF4_23295773_ChIP-Seq_U87_Human1.46983060
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45363290
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.44080851
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.42944327
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39034948
47RNF2_27304074_Chip-Seq_NSC_Mouse1.35188642
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34887017
49TP53_18474530_ChIP-ChIP_U2OS_Human1.33038699
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.30250351
51SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29414909
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28417736
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27078176
54YAP1_20516196_ChIP-Seq_MESCs_Mouse1.24428293
55SOX9_26525672_Chip-Seq_HEART_Mouse1.22604015
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22455737
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22103768
58TET1_21490601_ChIP-Seq_MESCs_Mouse1.20666549
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19532786
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19200556
61CBP_20019798_ChIP-Seq_JUKART_Human1.19200556
62MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19172519
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.18867432
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18309002
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17984883
66AR_19668381_ChIP-Seq_PC3_Human1.14109119
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13451148
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12885815
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11906637
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.10903885
71JUN_21703547_ChIP-Seq_K562_Human1.10612049
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09120149
73AR_25329375_ChIP-Seq_VCAP_Human1.08811119
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08010751
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08010751
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07934912
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.06901263
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.06821443
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06433101
80SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05562135
81KDM2B_26808549_Chip-Seq_REH_Human1.05492285
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.04786683
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.04568282
84SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04177591
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04095302
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03806139
87TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03424724
88DROSHA_22980978_ChIP-Seq_HELA_Human1.01839908
89RUNX2_22187159_ChIP-Seq_PCA_Human1.01741029
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01547461
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01388891
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.01316490
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00645337
94FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00244737
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99847193
96CMYC_18555785_Chip-Seq_ESCs_Mouse0.99323237
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97984177
98BRD4_25478319_ChIP-Seq_HGPS_Human0.97358134
99ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97055761
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96566193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol4.29330689
2MP0004859_abnormal_synaptic_plasticity3.68848779
3MP0003787_abnormal_imprinting3.21284384
4MP0003880_abnormal_central_pattern2.90274233
5MP0004270_analgesia2.88341304
6MP0003195_calcinosis2.86578520
7MP0005646_abnormal_pituitary_gland2.70823460
8MP0002234_abnormal_pharynx_morphology2.48858085
9MP0003635_abnormal_synaptic_transmissio2.39688555
10MP0000778_abnormal_nervous_system2.26872823
11MP0000013_abnormal_adipose_tissue2.20324074
12MP0004043_abnormal_pH_regulation2.04867283
13MP0002063_abnormal_learning/memory/cond2.03661766
14MP0008877_abnormal_DNA_methylation2.03192072
15MP0003123_paternal_imprinting1.99259968
16MP0001501_abnormal_sleep_pattern1.96697989
17MP0004811_abnormal_neuron_physiology1.90860887
18MP0009046_muscle_twitch1.90667398
19MP0000516_abnormal_urinary_system1.90184288
20MP0005367_renal/urinary_system_phenotyp1.90184288
21MP0005423_abnormal_somatic_nervous1.77834335
22MP0002734_abnormal_mechanical_nocicepti1.76696515
23MP0001188_hyperpigmentation1.75829535
24MP0002184_abnormal_innervation1.74906712
25MP0002572_abnormal_emotion/affect_behav1.73055767
26MP0004233_abnormal_muscle_weight1.71587284
27MP0000569_abnormal_digit_pigmentation1.69998978
28MP0004858_abnormal_nervous_system1.68368109
29MP0002272_abnormal_nervous_system1.67382919
30MP0002396_abnormal_hematopoietic_system1.66565362
31MP0009745_abnormal_behavioral_response1.66249403
32MP0002064_seizures1.62229042
33MP0000631_abnormal_neuroendocrine_gland1.61914586
34MP0005167_abnormal_blood-brain_barrier1.59847447
35MP0000955_abnormal_spinal_cord1.58611081
36MP0006276_abnormal_autonomic_nervous1.56231142
37MP0001661_extended_life_span1.53703031
38MP0003705_abnormal_hypodermis_morpholog1.53664948
39MP0003890_abnormal_embryonic-extraembry1.53362215
40MP0005623_abnormal_meninges_morphology1.45053060
41MP0003045_fibrosis1.39140800
42MP0003122_maternal_imprinting1.38052766
43MP0008438_abnormal_cutaneous_collagen1.35732675
44MP0004147_increased_porphyrin_level1.35025932
45MP0000566_synostosis1.32741573
46MP0003121_genomic_imprinting1.31400791
47MP0001968_abnormal_touch/_nociception1.31368128
48MP0004885_abnormal_endolymph1.30499246
49MP0010368_abnormal_lymphatic_system1.30008698
50MP0005076_abnormal_cell_differentiation1.29841517
51MP0002736_abnormal_nociception_after1.28584102
52MP0001440_abnormal_grooming_behavior1.26986163
53MP0003183_abnormal_peptide_metabolism1.25115987
54MP0001486_abnormal_startle_reflex1.24144953
55MP0002882_abnormal_neuron_morphology1.23155950
56MP0001984_abnormal_olfaction1.23044203
57MP0005451_abnormal_body_composition1.18515191
58MP0005409_darkened_coat_color1.18040113
59MP0001970_abnormal_pain_threshold1.17107605
60MP0002735_abnormal_chemical_nociception1.13339104
61MP0005187_abnormal_penis_morphology1.11854324
62MP0002067_abnormal_sensory_capabilities1.08364254
63MP0003633_abnormal_nervous_system1.06403205
64MP0002152_abnormal_brain_morphology1.05874309
65MP0002751_abnormal_autonomic_nervous1.05070241
66MP0001270_distended_abdomen1.04477470
67MP0005275_abnormal_skin_tensile1.03756596
68MP0003879_abnormal_hair_cell1.01299209
69MP0002069_abnormal_eating/drinking_beha0.93221610
70MP0002295_abnormal_pulmonary_circulatio0.92901634
71MP0002752_abnormal_somatic_nervous0.92496841
72MP0003631_nervous_system_phenotype0.90801489
73MP0010352_gastrointestinal_tract_polyps0.90341886
74MP0002557_abnormal_social/conspecific_i0.87774156
75MP0005551_abnormal_eye_electrophysiolog0.87335329
76MP0001919_abnormal_reproductive_system0.87078263
77MP0002066_abnormal_motor_capabilities/c0.86580361
78MP0003172_abnormal_lysosome_physiology0.85643705
79MP0003385_abnormal_body_wall0.83382389
80MP0003937_abnormal_limbs/digits/tail_de0.83054515
81MP0003861_abnormal_nervous_system0.81150372
82MP0000003_abnormal_adipose_tissue0.80931521
83MP0000534_abnormal_ureter_morphology0.80833298
84MP0008569_lethality_at_weaning0.78343529
85MP0002733_abnormal_thermal_nociception0.77353416
86MP0003935_abnormal_craniofacial_develop0.77330039
87MP0003646_muscle_fatigue0.75505316
88MP0000647_abnormal_sebaceous_gland0.75223186
89MP0002009_preneoplasia0.74819384
90MP0002896_abnormal_bone_mineralization0.71786472
91MP0002081_perinatal_lethality0.69615971
92MP0001286_abnormal_eye_development0.69325505
93MP0001502_abnormal_circadian_rhythm0.69086251
94MP0002168_other_aberrant_phenotype0.68694700
95MP0001915_intracranial_hemorrhage0.67894518
96MP0008995_early_reproductive_senescence0.67095607
97MP0002928_abnormal_bile_duct0.66340054
98MP0010234_abnormal_vibrissa_follicle0.65898776
99MP0002229_neurodegeneration0.65241355
100MP0004130_abnormal_muscle_cell0.65031852

Predicted human phenotypes

RankGene SetZ-score
1Sparse lateral eyebrow (HP:0005338)3.56297533
2Action tremor (HP:0002345)3.36638646
3Fatigue (HP:0012378)3.35862555
4Focal seizures (HP:0007359)3.16813275
5Focal motor seizures (HP:0011153)3.14215728
6Epileptic encephalopathy (HP:0200134)3.12005425
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.91868236
8Abnormality of alanine metabolism (HP:0010916)2.91868236
9Hyperalaninemia (HP:0003348)2.91868236
10Febrile seizures (HP:0002373)2.90492370
11Cortical dysplasia (HP:0002539)2.85016558
12Atonic seizures (HP:0010819)2.83022792
13Urinary urgency (HP:0000012)2.81607407
14Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.77502992
15Neoplasm of the adrenal cortex (HP:0100641)2.72963059
16Hepatoblastoma (HP:0002884)2.61703773
17Heterochromia iridis (HP:0001100)2.58323989
18Drooling (HP:0002307)2.52752053
19Asymmetry of the thorax (HP:0001555)2.51473096
20Abnormality of the fingertips (HP:0001211)2.46453026
21Medulloblastoma (HP:0002885)2.41937281
22Papilledema (HP:0001085)2.39753055
23Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.37377238
24Constricted visual fields (HP:0001133)2.28136909
25Excessive salivation (HP:0003781)2.27197046
26Spastic gait (HP:0002064)2.24028140
27Increased density of long bones (HP:0006392)2.23921974
28Absent eyebrow (HP:0002223)2.18324368
29Autoamputation (HP:0001218)2.17550013
30Ureteral obstruction (HP:0006000)2.16981684
31Anal stenosis (HP:0002025)2.16964607
32Ectopic kidney (HP:0000086)2.16859720
33Ureteral stenosis (HP:0000071)2.15816532
34Intention tremor (HP:0002080)2.15694515
35Ankle clonus (HP:0011448)2.13933478
36Abnormality of the astrocytes (HP:0100707)2.12781033
37Astrocytoma (HP:0009592)2.12781033
38Generalized myoclonic seizures (HP:0002123)2.12671790
39Overgrowth (HP:0001548)2.06152555
40Truncal ataxia (HP:0002078)2.06000782
41Long palpebral fissure (HP:0000637)2.05577388
42Transitional cell carcinoma of the bladder (HP:0006740)2.03532932
43Concave nail (HP:0001598)2.02282814
44Bladder carcinoma (HP:0002862)2.01334864
45Bladder neoplasm (HP:0009725)2.01334864
46Agitation (HP:0000713)1.99015846
47Insidious onset (HP:0003587)1.97792540
48Termporal pattern (HP:0011008)1.97792540
49Amblyopia (HP:0000646)1.97702063
50Hemiparesis (HP:0001269)1.96811355
51Complete atrioventricular canal defect (HP:0001674)1.96382903
52Glioma (HP:0009733)1.96256472
53Broad ribs (HP:0000885)1.95416062
54Mild short stature (HP:0003502)1.95184919
55Cubitus valgus (HP:0002967)1.94326931
56Dialeptic seizures (HP:0011146)1.93899473
57Generalized tonic-clonic seizures (HP:0002069)1.93861409
58Abnormality of the periventricular white matter (HP:0002518)1.93834892
59Abnormality of the lower motor neuron (HP:0002366)1.91041562
60Tubulointerstitial nephritis (HP:0001970)1.89221482
61Absent speech (HP:0001344)1.87249485
62Pheochromocytoma (HP:0002666)1.85844489
63Absence seizures (HP:0002121)1.84035188
64Impaired vibration sensation in the lower limbs (HP:0002166)1.82996021
65Wide intermamillary distance (HP:0006610)1.81898829
66Short 5th finger (HP:0009237)1.81657533
67Keratoconus (HP:0000563)1.80939581
68Increased corneal curvature (HP:0100692)1.80939581
69Status epilepticus (HP:0002133)1.79440222
70Lower limb hyperreflexia (HP:0002395)1.79181142
71Ectropion (HP:0000656)1.78356721
72Hypoplastic nipples (HP:0002557)1.78062672
73Reduced subcutaneous adipose tissue (HP:0003758)1.77242294
74Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.75449134
75Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.75287959
76Anhidrosis (HP:0000970)1.74811651
77Epileptiform EEG discharges (HP:0011182)1.74456443
78Increased circulating renin level (HP:0000848)1.74353334
79Depression (HP:0000716)1.73673097
80Visceral angiomatosis (HP:0100761)1.73419441
81Neoplasm of the heart (HP:0100544)1.72553243
82EEG with generalized epileptiform discharges (HP:0011198)1.71652312
83Ependymoma (HP:0002888)1.71080061
84Hammertoe (HP:0001765)1.67925939
85Progressive cerebellar ataxia (HP:0002073)1.66353512
86Lower limb muscle weakness (HP:0007340)1.65863891
87Malignant neoplasm of the central nervous system (HP:0100836)1.64741332
88Hypsarrhythmia (HP:0002521)1.63214721
89Orthostatic hypotension (HP:0001278)1.62973238
90Myokymia (HP:0002411)1.62781345
91Clonus (HP:0002169)1.62559588
92Depressed nasal tip (HP:0000437)1.62365944
93Delayed CNS myelination (HP:0002188)1.60940473
94Atrioventricular canal defect (HP:0006695)1.60681018
95Short chin (HP:0000331)1.60302066
96Unsteady gait (HP:0002317)1.60134345
97Failure to thrive in infancy (HP:0001531)1.59436626
98Delusions (HP:0000746)1.58913732
99Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.58345937
100Hemangiomatosis (HP:0007461)1.57451466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.43643736
2MARK13.21283802
3NTRK23.04114818
4CCNB12.84946900
5MAP3K42.83809323
6EPHA32.65911586
7MAP2K72.55874832
8STK242.48631362
9BCKDK2.13330664
10EPHA42.08253696
11TESK21.95798397
12NTRK31.94467289
13PLK21.92539674
14JAK31.71392010
15FRK1.64957222
16CAMK1G1.64564003
17TAOK31.60395438
18MAPK131.55957515
19WNK11.55866795
20SRPK11.54588852
21SGK21.50356875
22ERBB31.48084440
23MINK11.46592282
24SGK4941.46585997
25SGK2231.46585997
26DAPK21.40951633
27CAMKK21.39756011
28MAP3K21.39737205
29CAMK1D1.38489558
30MAP3K31.37035564
31ZAK1.31225229
32PAK61.30880702
33NTRK11.29467018
34SGK31.28836988
35WNK41.28460739
36CSNK1A1L1.12354247
37PAK31.11681607
38AKT31.11651840
39CAMK11.10795602
40CAMK41.10176730
41BCR1.09313777
42TRIM281.09288023
43PINK11.08860869
44CDK91.06267612
45CLK11.02885293
46MAP4K21.02868807
47FLT31.01143839
48EIF2AK30.97499674
49DYRK30.97488218
50UHMK10.96447448
51CSNK1G30.93519893
52SCYL20.92087368
53DYRK20.91589039
54BRD40.81725947
55CSNK1G20.80807996
56STK390.78162583
57FGR0.77878403
58SIK20.77669331
59MAP3K60.77641806
60PRKCG0.77212771
61CDK50.76737566
62PRKD30.76655098
63DAPK10.71086498
64CAMKK10.71065470
65MAP2K40.70440214
66SGK10.67834799
67EEF2K0.67547800
68PDGFRA0.59123101
69CSNK1G10.57937263
70RPS6KA20.53042385
71EIF2AK10.52188439
72PRKCE0.50105538
73MTOR0.49832043
74JAK10.49791297
75CAMK2B0.49324833
76RPS6KA40.49019131
77DYRK1B0.43970216
78ILK0.42330215
79PRKAA10.41996434
80CDK60.41881086
81MAP3K50.41829863
82FER0.41439432
83YES10.39128852
84PRKCQ0.38335290
85PKN20.38099082
86NEK10.37347467
87CDK190.35488763
88MAPK100.35483923
89CAMK2A0.34209212
90CHEK20.33374094
91PHKG20.32758463
92PHKG10.32758463
93PNCK0.32254171
94NEK60.32084233
95PRKCH0.31961741
96CDK140.31727405
97RPS6KC10.31382966
98RPS6KL10.31382966
99WNK30.31220714
100RAF10.29856394

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.54636369
2GABAergic synapse_Homo sapiens_hsa047272.91735050
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54677578
4Dopaminergic synapse_Homo sapiens_hsa047282.54668972
5Synaptic vesicle cycle_Homo sapiens_hsa047212.47755048
6Circadian entrainment_Homo sapiens_hsa047132.47497045
7Morphine addiction_Homo sapiens_hsa050322.45658779
8Glutamatergic synapse_Homo sapiens_hsa047242.16029320
9Arginine biosynthesis_Homo sapiens_hsa002201.79657680
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73619387
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.70214474
12Long-term depression_Homo sapiens_hsa047301.64808519
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64249041
14Axon guidance_Homo sapiens_hsa043601.54287514
15Long-term potentiation_Homo sapiens_hsa047201.53436867
16Cholinergic synapse_Homo sapiens_hsa047251.46118997
17Regulation of autophagy_Homo sapiens_hsa041401.40190770
18Amphetamine addiction_Homo sapiens_hsa050311.39198383
19Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.36299165
20AMPK signaling pathway_Homo sapiens_hsa041521.35445439
21Collecting duct acid secretion_Homo sapiens_hsa049661.24807345
22Alcoholism_Homo sapiens_hsa050341.23210091
23Lysine degradation_Homo sapiens_hsa003101.22897504
24Glioma_Homo sapiens_hsa052141.11850076
25mTOR signaling pathway_Homo sapiens_hsa041501.04957681
26Serotonergic synapse_Homo sapiens_hsa047261.03401238
27Gap junction_Homo sapiens_hsa045401.02680231
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.02027451
29Cocaine addiction_Homo sapiens_hsa050300.99476066
30Salivary secretion_Homo sapiens_hsa049700.99251255
31Ras signaling pathway_Homo sapiens_hsa040140.99171069
32mRNA surveillance pathway_Homo sapiens_hsa030150.98015032
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97695829
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96543700
35Vibrio cholerae infection_Homo sapiens_hsa051100.94855335
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92527677
37Insulin secretion_Homo sapiens_hsa049110.91787689
38Non-homologous end-joining_Homo sapiens_hsa034500.91362653
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90756532
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88117130
41Sphingolipid signaling pathway_Homo sapiens_hsa040710.87921927
42Renal cell carcinoma_Homo sapiens_hsa052110.87176623
43Oxytocin signaling pathway_Homo sapiens_hsa049210.86972909
44Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85585637
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84500298
46Adherens junction_Homo sapiens_hsa045200.82593556
47ErbB signaling pathway_Homo sapiens_hsa040120.82323841
48Choline metabolism in cancer_Homo sapiens_hsa052310.82277007
49Selenocompound metabolism_Homo sapiens_hsa004500.81773355
50Taste transduction_Homo sapiens_hsa047420.81377241
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80240553
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78969939
53Colorectal cancer_Homo sapiens_hsa052100.78741200
54Endocytosis_Homo sapiens_hsa041440.78303619
55Propanoate metabolism_Homo sapiens_hsa006400.78046126
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76717627
57GnRH signaling pathway_Homo sapiens_hsa049120.76298423
58Type II diabetes mellitus_Homo sapiens_hsa049300.73058129
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.72532866
60Estrogen signaling pathway_Homo sapiens_hsa049150.71689535
61Endometrial cancer_Homo sapiens_hsa052130.71609943
62Phototransduction_Homo sapiens_hsa047440.70580752
63Insulin signaling pathway_Homo sapiens_hsa049100.68490928
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68318696
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68217187
66Prolactin signaling pathway_Homo sapiens_hsa049170.67866206
67Hippo signaling pathway_Homo sapiens_hsa043900.67157463
68Melanogenesis_Homo sapiens_hsa049160.67069671
69PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66038021
70Inositol phosphate metabolism_Homo sapiens_hsa005620.65579531
71Circadian rhythm_Homo sapiens_hsa047100.64440609
72cAMP signaling pathway_Homo sapiens_hsa040240.64168697
73Focal adhesion_Homo sapiens_hsa045100.61393482
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60429115
75Oocyte meiosis_Homo sapiens_hsa041140.59900120
76Phagosome_Homo sapiens_hsa041450.57481594
77Steroid biosynthesis_Homo sapiens_hsa001000.56926423
78One carbon pool by folate_Homo sapiens_hsa006700.56862397
79Olfactory transduction_Homo sapiens_hsa047400.56515217
80Rap1 signaling pathway_Homo sapiens_hsa040150.56395751
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54756554
82Non-small cell lung cancer_Homo sapiens_hsa052230.54240637
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53932482
84Calcium signaling pathway_Homo sapiens_hsa040200.53308078
85Gastric acid secretion_Homo sapiens_hsa049710.51175550
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51058709
87Renin secretion_Homo sapiens_hsa049240.50610883
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50261894
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50037787
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49900280
91Sulfur metabolism_Homo sapiens_hsa009200.46991952
92Thyroid cancer_Homo sapiens_hsa052160.46233541
93Dorso-ventral axis formation_Homo sapiens_hsa043200.45901742
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43032781
95MicroRNAs in cancer_Homo sapiens_hsa052060.42612942
96Pancreatic cancer_Homo sapiens_hsa052120.42509131
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.41215405
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40196997
99Vitamin B6 metabolism_Homo sapiens_hsa007500.38966539
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37321653

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