PIGC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)6.38997420
2signal peptide processing (GO:0006465)6.03485090
3central nervous system myelination (GO:0022010)5.94606537
4axon ensheathment in central nervous system (GO:0032291)5.94606537
5cholesterol biosynthetic process (GO:0006695)4.40585158
6mannosylation (GO:0097502)4.39296279
7L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.30523794
8amyloid precursor protein catabolic process (GO:0042987)4.24796281
9cotranslational protein targeting to membrane (GO:0006613)4.17976771
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.16127460
11NADH dehydrogenase complex assembly (GO:0010257)4.16127460
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.16127460
13nucleotide transmembrane transport (GO:1901679)4.11711543
14regulation of mitotic spindle checkpoint (GO:1903504)4.10055929
15regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.10055929
16rRNA modification (GO:0000154)4.07253133
17protein targeting to ER (GO:0045047)4.06827959
18eye photoreceptor cell differentiation (GO:0001754)4.05605319
19photoreceptor cell differentiation (GO:0046530)4.05605319
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.04266407
21cullin deneddylation (GO:0010388)4.01669578
22protein neddylation (GO:0045116)3.98803586
23sterol biosynthetic process (GO:0016126)3.97514194
24protein localization to endoplasmic reticulum (GO:0070972)3.95464198
25establishment of protein localization to endoplasmic reticulum (GO:0072599)3.89236215
26cytochrome complex assembly (GO:0017004)3.88677367
27protein complex biogenesis (GO:0070271)3.84080175
28protein-cofactor linkage (GO:0018065)3.74054791
29chaperone-mediated protein transport (GO:0072321)3.72435223
30myelination (GO:0042552)3.71652637
31ribosomal small subunit assembly (GO:0000028)3.70192681
32axon ensheathment (GO:0008366)3.69105781
33ensheathment of neurons (GO:0007272)3.69105781
34positive regulation of cellular amine metabolic process (GO:0033240)3.67274212
35fucosylation (GO:0036065)3.62213595
36rRNA methylation (GO:0031167)3.56890030
37regulation of metalloenzyme activity (GO:0048552)3.53790695
38viral transcription (GO:0019083)3.51404067
39fucose metabolic process (GO:0006004)3.50657715
40amyloid precursor protein metabolic process (GO:0042982)3.50471670
41isoprenoid biosynthetic process (GO:0008299)3.47750103
42DNA double-strand break processing (GO:0000729)3.45639658
43regulation of cellular amino acid metabolic process (GO:0006521)3.43197617
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42262459
45* GPI anchor biosynthetic process (GO:0006506)3.40865179
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.40200265
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.40200265
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.38868991
49long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.36677817
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.36226962
51metallo-sulfur cluster assembly (GO:0031163)3.34742907
52iron-sulfur cluster assembly (GO:0016226)3.34742907
53mitochondrial respiratory chain complex assembly (GO:0033108)3.34547894
54mitochondrial RNA metabolic process (GO:0000959)3.33545899
55translational termination (GO:0006415)3.32774995
56kinetochore assembly (GO:0051382)3.31800252
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.31637898
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.31637898
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.31637898
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.31224343
61chromatin remodeling at centromere (GO:0031055)3.27262646
62mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26950984
63CENP-A containing nucleosome assembly (GO:0034080)3.26367916
64intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.22857745
65signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.22857745
66long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.21178465
67amino acid salvage (GO:0043102)3.20683965
68L-methionine salvage (GO:0071267)3.20683965
69L-methionine biosynthetic process (GO:0071265)3.20683965
70negative regulation of DNA-dependent DNA replication (GO:2000104)3.20091050
71DNA damage response, detection of DNA damage (GO:0042769)3.18879368
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.18232640
73water-soluble vitamin biosynthetic process (GO:0042364)3.17658831
74respiratory chain complex IV assembly (GO:0008535)3.17329511
75signal transduction involved in cell cycle checkpoint (GO:0072395)3.15638279
76peptidyl-histidine modification (GO:0018202)3.12367029
77signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12206574
78signal transduction involved in DNA damage checkpoint (GO:0072422)3.12206574
79base-excision repair, AP site formation (GO:0006285)3.09726664
80negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02209819
81negative regulation of ligase activity (GO:0051352)3.02209819
82DNA deamination (GO:0045006)2.99720575
83kinetochore organization (GO:0051383)2.99440957
84positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97734811
85* preassembly of GPI anchor in ER membrane (GO:0016254)2.97557783
86neural tube formation (GO:0001841)2.97531237
87protein targeting to mitochondrion (GO:0006626)2.96926665
88ribosomal small subunit biogenesis (GO:0042274)2.95499923
89viral protein processing (GO:0019082)2.95133240
90response to redox state (GO:0051775)2.95058495
91protein targeting to membrane (GO:0006612)2.94929396
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94505399
93oligodendrocyte differentiation (GO:0048709)2.93878723
94pseudouridine synthesis (GO:0001522)2.93863445
95anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93258397
96proteasome assembly (GO:0043248)2.92849761
97fatty-acyl-CoA metabolic process (GO:0035337)2.92489000
98inner mitochondrial membrane organization (GO:0007007)2.92161919
99DNA ligation (GO:0006266)2.91189479
100regulation of mitochondrial translation (GO:0070129)2.90847330
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89759021
102very long-chain fatty acid metabolic process (GO:0000038)2.88560162
103glycosylceramide metabolic process (GO:0006677)2.87999313
104positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.87302579
105viral life cycle (GO:0019058)2.85795159
106protein localization to mitochondrion (GO:0070585)2.84581476
107pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.82870773
108virion attachment to host cell (GO:0019062)2.82617032
109adhesion of symbiont to host cell (GO:0044650)2.82617032
110regulation of cilium movement (GO:0003352)2.82604740
111leukocyte migration involved in inflammatory response (GO:0002523)2.81965805
112fucose catabolic process (GO:0019317)2.81830309
113L-fucose metabolic process (GO:0042354)2.81830309
114L-fucose catabolic process (GO:0042355)2.81830309
115establishment of protein localization to mitochondrion (GO:0072655)2.81648921
116histone exchange (GO:0043486)2.81620548
117positive regulation of ligase activity (GO:0051351)2.81284575
118magnesium ion transport (GO:0015693)2.79994623
119deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.78833767
120tRNA processing (GO:0008033)2.78463450
121substantia nigra development (GO:0021762)2.78287413
122DNA catabolic process, exonucleolytic (GO:0000738)2.78226016
123mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77098886
124establishment of protein localization to mitochondrial membrane (GO:0090151)2.76617076
125membrane protein ectodomain proteolysis (GO:0006509)2.75380839
126platelet dense granule organization (GO:0060155)2.72945450
127DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.72250569
128lactate metabolic process (GO:0006089)2.71421555
129* GPI anchor metabolic process (GO:0006505)2.70807253
130tRNA metabolic process (GO:0006399)2.70665375
131sequestering of actin monomers (GO:0042989)2.69465138
132translational elongation (GO:0006414)2.68668755
133pyrimidine nucleotide catabolic process (GO:0006244)2.68146754
134GDP-mannose metabolic process (GO:0019673)2.67332651
135anterograde synaptic vesicle transport (GO:0048490)2.66956778
136ubiquinone biosynthetic process (GO:0006744)2.66474295
137respiratory electron transport chain (GO:0022904)2.64585941
138ER overload response (GO:0006983)2.64390722
139fatty-acyl-CoA biosynthetic process (GO:0046949)2.62753830
140energy coupled proton transport, down electrochemical gradient (GO:0015985)2.62573297
141ATP synthesis coupled proton transport (GO:0015986)2.62573297
142response to pheromone (GO:0019236)2.61155959
143organelle disassembly (GO:1903008)2.61135191
144negative regulation of chemokine production (GO:0032682)2.60513673
145negative regulation of neurotransmitter secretion (GO:0046929)2.60432700
146long-chain fatty acid biosynthetic process (GO:0042759)2.60207405
147creatine metabolic process (GO:0006600)2.59613421
148GMP metabolic process (GO:0046037)2.59544640
149establishment of integrated proviral latency (GO:0075713)2.59113115
150* C-terminal protein amino acid modification (GO:0018410)2.59096950
151transcription from mitochondrial promoter (GO:0006390)2.58843706
152DNA replication-independent nucleosome organization (GO:0034724)2.58505250
153DNA replication-independent nucleosome assembly (GO:0006336)2.58505250
154replication fork processing (GO:0031297)2.57617986
155recombinational repair (GO:0000725)2.57439603
156antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.57359223
157electron transport chain (GO:0022900)2.57209578
158regulation of autophagic vacuole assembly (GO:2000785)2.56606501
159DNA replication checkpoint (GO:0000076)2.56265460
160transcription elongation from RNA polymerase III promoter (GO:0006385)2.56103593
161termination of RNA polymerase III transcription (GO:0006386)2.56103593
162cranial nerve morphogenesis (GO:0021602)2.55901474
163myelin maintenance (GO:0043217)2.55673314
164membrane protein intracellular domain proteolysis (GO:0031293)2.55591769
165carbohydrate derivative transport (GO:1901264)2.53295882
166nucleoside diphosphate catabolic process (GO:0009134)2.52654391
167* C-terminal protein lipidation (GO:0006501)2.50495638
168sphingosine metabolic process (GO:0006670)2.46375571
169aldehyde catabolic process (GO:0046185)2.45586565
170nuclear envelope reassembly (GO:0031468)2.43761082
171mitotic nuclear envelope reassembly (GO:0007084)2.43761082
172cellular protein complex disassembly (GO:0043624)2.42811306
173positive regulation of interleukin-17 production (GO:0032740)2.42357713
174polyketide metabolic process (GO:0030638)2.42180698
175doxorubicin metabolic process (GO:0044598)2.42180698
176daunorubicin metabolic process (GO:0044597)2.42180698
177positive regulation of oligodendrocyte differentiation (GO:0048714)2.39827605
178ether lipid metabolic process (GO:0046485)2.38570057
179protein deneddylation (GO:0000338)2.37991660

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.35785050
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.25574820
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.58514971
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.44594579
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22954434
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.15801124
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.10399825
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.90622875
9PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.85251542
10ZNF274_21170338_ChIP-Seq_K562_Hela2.53966846
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47407220
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.44845220
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42924314
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42102588
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37541191
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27129753
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24920322
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20074267
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18670734
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.13326447
21* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.09635230
22ERG_20887958_ChIP-Seq_HPC-7_Mouse2.07966251
23PADI4_21655091_ChIP-ChIP_MCF-7_Human2.06860986
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.01148660
25* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.99108299
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.95772440
27* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79107072
28* ELK1_19687146_ChIP-ChIP_HELA_Human1.78014162
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.77584654
30HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75923292
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70828190
32E2F7_22180533_ChIP-Seq_HELA_Human1.70622247
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69455570
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.68332273
35MYC_18940864_ChIP-ChIP_HL60_Human1.65333202
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64395566
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62853744
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59641166
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56040253
40STAT1_20625510_ChIP-Seq_HELA_Human1.51822146
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51293038
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.51176834
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51100026
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50943398
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49936999
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.49336803
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.49211826
48TTF2_22483619_ChIP-Seq_HELA_Human1.48536496
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48041596
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47023206
51VDR_23849224_ChIP-Seq_CD4+_Human1.46865984
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43903355
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.43478196
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42725305
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42398103
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39389875
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38505026
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34152023
59KDM5A_27292631_Chip-Seq_BREAST_Human1.32588529
60* TP53_22573176_ChIP-Seq_HFKS_Human1.31815272
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31456954
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30975743
63DCP1A_22483619_ChIP-Seq_HELA_Human1.28590752
64XRN2_22483619_ChIP-Seq_HELA_Human1.28506771
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28271481
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27105363
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26509457
68SCL_19346495_ChIP-Seq_HPC-7_Human1.26467718
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26449442
70FUS_26573619_Chip-Seq_HEK293_Human1.22837908
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22517119
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22517119
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.18592092
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.17878142
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.17631762
76CIITA_25753668_ChIP-Seq_RAJI_Human1.17288528
77VDR_22108803_ChIP-Seq_LS180_Human1.16438963
78SOX2_20726797_ChIP-Seq_SW620_Human1.15834765
79FOXP3_21729870_ChIP-Seq_TREG_Human1.13853446
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12820570
81IGF1R_20145208_ChIP-Seq_DFB_Human1.12576739
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10978916
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10477273
84* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08240955
85IRF1_19129219_ChIP-ChIP_H3396_Human1.08079634
86SPI1_23547873_ChIP-Seq_NB4_Human1.07732760
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07540859
88TAF15_26573619_Chip-Seq_HEK293_Human1.07003937
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05355343
90EWS_26573619_Chip-Seq_HEK293_Human1.04306568
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03720364
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.03720364
93P300_19829295_ChIP-Seq_ESCs_Human1.03180673
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01958023
95* LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00923297
96HTT_18923047_ChIP-ChIP_STHdh_Human1.00112585
97AR_20517297_ChIP-Seq_VCAP_Human0.99471006
98ER_23166858_ChIP-Seq_MCF-7_Human0.99134550
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99082506
100E2F1_21310950_ChIP-Seq_MCF-7_Human0.98772211
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98526082
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97492296
103GBX2_23144817_ChIP-Seq_PC3_Human0.96369331
104* TFEB_21752829_ChIP-Seq_HELA_Human0.95501653
105* EZH2_27294783_Chip-Seq_NPCs_Mouse0.95348226
106* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95341342
107GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95230447
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95179248
109ERG_20517297_ChIP-Seq_VCAP_Human0.94827048
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94693099
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94301704
112POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93619398
113E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93095777
114TAL1_26923725_Chip-Seq_HPCs_Mouse0.93084898
115* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92727490
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92719222
117LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91371573
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89518949
119* NFE2_27457419_Chip-Seq_LIVER_Mouse0.88549865
120MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87929247
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87778456
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87763784
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87246789
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86994015
125STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86841385
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86417522
127* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85060757
128SALL4_22934838_ChIP-ChIP_CD34+_Human0.83995425
129CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83684710
130HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83536673
131* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82915281
132FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82637324
133CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82378425
134ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82007249
135CBP_20019798_ChIP-Seq_JUKART_Human0.81814848
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81814848
137HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81477652
138* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.81411512
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80995872
140NOTCH1_21737748_ChIP-Seq_TLL_Human0.80968836
141SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.79817410
142NANOG_19829295_ChIP-Seq_ESCs_Human0.79427664
143SOX2_19829295_ChIP-Seq_ESCs_Human0.79427664
144NANOG_20526341_ChIP-Seq_ESCs_Human0.79282625
145* SOX17_20123909_ChIP-Seq_XEN_Mouse0.79194424
146GATA3_26560356_Chip-Seq_TH2_Human0.76570660
147GABP_19822575_ChIP-Seq_HepG2_Human0.75935228
148RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.75669763
149* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75579574
150MYB_21317192_ChIP-Seq_ERMYB_Mouse0.74521957
151ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74296342
152EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.72907932
153VDR_24763502_ChIP-Seq_THP-1_Human0.72406334
154ETV2_25802403_ChIP-Seq_MESCs_Mouse0.72223558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.88603815
2MP0009379_abnormal_foot_pigmentation3.70999223
3MP0000920_abnormal_myelination3.63388938
4MP0008058_abnormal_DNA_repair3.40478089
5MP0003950_abnormal_plasma_membrane3.28917239
6MP0003787_abnormal_imprinting3.23600272
7MP0001905_abnormal_dopamine_level3.14872875
8MP0005645_abnormal_hypothalamus_physiol3.06091454
9MP0008438_abnormal_cutaneous_collagen2.79322081
10MP0008995_early_reproductive_senescence2.75174578
11MP0003183_abnormal_peptide_metabolism2.72461813
12MP0004147_increased_porphyrin_level2.70371986
13MP0003786_premature_aging2.60182033
14MP0002102_abnormal_ear_morphology2.52918431
15MP0005220_abnormal_exocrine_pancreas2.34709115
16MP0006292_abnormal_olfactory_placode2.31713869
17MP0000566_synostosis2.31243866
18MP0000465_gastrointestinal_hemorrhage2.28657161
19MP0006054_spinal_hemorrhage2.18409361
20MP0001529_abnormal_vocalization2.13867742
21MP0003195_calcinosis2.13571160
22MP0001986_abnormal_taste_sensitivity2.10108764
23MP0005408_hypopigmentation2.09701402
24MP0003724_increased_susceptibility_to2.09604636
25MP0002938_white_spotting2.07568039
26MP0008789_abnormal_olfactory_epithelium2.03199245
27MP0003656_abnormal_erythrocyte_physiolo2.02119708
28MP0005410_abnormal_fertilization1.99227748
29MP0003121_genomic_imprinting1.99092040
30MP0004381_abnormal_hair_follicle1.97004813
31MP0005084_abnormal_gallbladder_morpholo1.92831348
32MP0009333_abnormal_splenocyte_physiolog1.85809356
33MP0003122_maternal_imprinting1.83835855
34MP0010094_abnormal_chromosome_stability1.74267716
35MP0008057_abnormal_DNA_replication1.71509434
36MP0000613_abnormal_salivary_gland1.70750165
37MP0003806_abnormal_nucleotide_metabolis1.68275710
38MP0003693_abnormal_embryo_hatching1.67295221
39MP0000013_abnormal_adipose_tissue1.66406476
40MP0002933_joint_inflammation1.65754373
41MP0002638_abnormal_pupillary_reflex1.64201377
42MP0005379_endocrine/exocrine_gland_phen1.61783167
43MP0009384_cardiac_valve_regurgitation1.60759569
44MP0003186_abnormal_redox_activity1.58864469
45MP0005083_abnormal_biliary_tract1.58676346
46MP0005075_abnormal_melanosome_morpholog1.58005939
47MP0002837_dystrophic_cardiac_calcinosis1.56990010
48MP0010386_abnormal_urinary_bladder1.56658273
49MP0002277_abnormal_respiratory_mucosa1.55414354
50MP0008007_abnormal_cellular_replicative1.54059130
51MP0004134_abnormal_chest_morphology1.53649579
52MP0005499_abnormal_olfactory_system1.53260123
53MP0005394_taste/olfaction_phenotype1.53260123
54MP0001984_abnormal_olfaction1.49417255
55MP0005253_abnormal_eye_physiology1.49272909
56MP0003718_maternal_effect1.48844255
57MP0000462_abnormal_digestive_system1.47718075
58MP0000015_abnormal_ear_pigmentation1.46165354
59MP0005367_renal/urinary_system_phenotyp1.44037842
60MP0000516_abnormal_urinary_system1.44037842
61MP0002095_abnormal_skin_pigmentation1.43261848
62MP0002132_abnormal_respiratory_system1.40977589
63MP0005671_abnormal_response_to1.39920575
64MP0005451_abnormal_body_composition1.37382189
65MP0005409_darkened_coat_color1.36401390
66MP0004142_abnormal_muscle_tone1.36233135
67MP0006072_abnormal_retinal_apoptosis1.34505267
68MP0005503_abnormal_tendon_morphology1.33268180
69MP0004957_abnormal_blastocyst_morpholog1.31954896
70MP0006035_abnormal_mitochondrial_morpho1.31632669
71MP0000678_abnormal_parathyroid_gland1.27259250
72MP0002396_abnormal_hematopoietic_system1.27182216
73MP0005636_abnormal_mineral_homeostasis1.27149460
74MP0003959_abnormal_lean_body1.25046865
75MP0002295_abnormal_pulmonary_circulatio1.24316778
76MP0000372_irregular_coat_pigmentation1.20502320
77MP0001879_abnormal_lymphatic_vessel1.16875128
78MP0005174_abnormal_tail_pigmentation1.14932806
79MP0002736_abnormal_nociception_after1.14442223
80MP0009250_abnormal_appendicular_skeleto1.14046490
81MP0003011_delayed_dark_adaptation1.13206909
82MP0002822_catalepsy1.12877638
83MP0008260_abnormal_autophagy1.12505602
84MP0003077_abnormal_cell_cycle1.12059898
85MP0001485_abnormal_pinna_reflex1.11642864
86MP0003880_abnormal_central_pattern1.11516496
87MP0005058_abnormal_lysosome_morphology1.06441711
88MP0009697_abnormal_copulation1.04028123
89MP0009785_altered_susceptibility_to1.03621552
90MP0005275_abnormal_skin_tensile1.02059392
91MP0008872_abnormal_physiological_respon1.00062362
92MP0000427_abnormal_hair_cycle0.99524324
93MP0000681_abnormal_thyroid_gland0.99347113
94MP0005508_abnormal_skeleton_morphology0.99017602
95MP0003111_abnormal_nucleus_morphology0.98344057
96MP0005389_reproductive_system_phenotype0.97868892
97MP0002098_abnormal_vibrissa_morphology0.94820310
98MP0008932_abnormal_embryonic_tissue0.93486389
99MP0000049_abnormal_middle_ear0.93386007
100MP0002090_abnormal_vision0.93212748
101MP0002419_abnormal_innate_immunity0.93196685
102MP0003943_abnormal_hepatobiliary_system0.92527462
103MP0003634_abnormal_glial_cell0.92510677
104MP0006036_abnormal_mitochondrial_physio0.92361200
105MP0000647_abnormal_sebaceous_gland0.92095531
106MP0001542_abnormal_bone_strength0.91942501
107MP0001929_abnormal_gametogenesis0.91600062
108MP0001944_abnormal_pancreas_morphology0.91176040
109MP0001188_hyperpigmentation0.90575510
110MP0002177_abnormal_outer_ear0.89713568
111MP0005171_absent_coat_pigmentation0.89640079
112MP0004133_heterotaxia0.88567066
113MP0006276_abnormal_autonomic_nervous0.87304317
114MP0006082_CNS_inflammation0.87091708
115MP0002693_abnormal_pancreas_physiology0.87032122
116MP0000358_abnormal_cell_content/0.86705675
117MP0002148_abnormal_hypersensitivity_rea0.86650376
118MP0002160_abnormal_reproductive_system0.86361683
119MP0000003_abnormal_adipose_tissue0.85374645
120MP0002751_abnormal_autonomic_nervous0.84943117
121MP0005551_abnormal_eye_electrophysiolog0.84908510
122MP0005332_abnormal_amino_acid0.84368110
123MP0003868_abnormal_feces_composition0.83122295
124MP0008873_increased_physiological_sensi0.82871600
125MP0004272_abnormal_basement_membrane0.82825522
126MP0001873_stomach_inflammation0.81291761
127MP0000569_abnormal_digit_pigmentation0.81241793
128MP0005025_abnormal_response_to0.81028023
129MP0002254_reproductive_system_inflammat0.81013402
130MP0001666_abnormal_nutrient_absorption0.80374351
131MP0001243_abnormal_dermal_layer0.80116143
132MP0000685_abnormal_immune_system0.79951625
133MP0008875_abnormal_xenobiotic_pharmacok0.79662798
134MP0004742_abnormal_vestibular_system0.79619953
135MP0001293_anophthalmia0.79618031
136MP0002060_abnormal_skin_morphology0.79402881
137MP0004043_abnormal_pH_regulation0.79382829
138MP0001119_abnormal_female_reproductive0.79221453
139MP0000653_abnormal_sex_gland0.78949142
140MP0000639_abnormal_adrenal_gland0.78656578
141MP0005164_abnormal_response_to0.78230314
142MP0001324_abnormal_eye_pigmentation0.77183252
143MP0002249_abnormal_larynx_morphology0.76483296
144MP0002163_abnormal_gland_morphology0.76390974
145MP0001764_abnormal_homeostasis0.75835692
146MP0005381_digestive/alimentary_phenotyp0.75677885
147MP0001968_abnormal_touch/_nociception0.75596808
148MP0001919_abnormal_reproductive_system0.75321488
149MP0002210_abnormal_sex_determination0.75205636
150MP0001851_eye_inflammation0.74982817
151MP0002420_abnormal_adaptive_immunity0.74671375
152MP0005390_skeleton_phenotype0.74652337
153MP0003938_abnormal_ear_development0.74070844
154MP0001145_abnormal_male_reproductive0.73930976
155MP0005000_abnormal_immune_tolerance0.73538942
156MP0001533_abnormal_skeleton_physiology0.72812298
157MP0004270_analgesia0.71448412
158MP0003136_yellow_coat_color0.71339810
159MP0005266_abnormal_metabolism0.71241251
160MP0000163_abnormal_cartilage_morphology0.70748324
161MP0003567_abnormal_fetal_cardiomyocyte0.69627126
162MP0001819_abnormal_immune_cell0.69553473
163MP0005595_abnormal_vascular_smooth0.69336245
164MP0000371_diluted_coat_color0.68826374
165MP0003763_abnormal_thymus_physiology0.68364747
166MP0005646_abnormal_pituitary_gland0.68230458
167MP0005387_immune_system_phenotype0.66521589
168MP0001790_abnormal_immune_system0.66521589
169MP0001545_abnormal_hematopoietic_system0.65201551
170MP0005397_hematopoietic_system_phenotyp0.65201551
171MP0005085_abnormal_gallbladder_physiolo0.64640694
172MP0002653_abnormal_ependyma_morphology0.64624047
173MP0003221_abnormal_cardiomyocyte_apopto0.64360596

Predicted human phenotypes

RankGene SetZ-score
1Renal Fanconi syndrome (HP:0001994)4.00194329
2Mitochondrial inheritance (HP:0001427)3.86087939
3Hepatocellular necrosis (HP:0001404)3.71555228
4Parakeratosis (HP:0001036)3.66677028
5Acute necrotizing encephalopathy (HP:0006965)3.63798158
6Aplasia/Hypoplasia of the sacrum (HP:0008517)3.55505015
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.52680281
8Increased hepatocellular lipid droplets (HP:0006565)3.45193600
9Abnormal mitochondria in muscle tissue (HP:0008316)3.32285089
10Lipid accumulation in hepatocytes (HP:0006561)3.27964597
11Hepatic necrosis (HP:0002605)3.27464925
12Medial flaring of the eyebrow (HP:0010747)3.10985674
13Acute encephalopathy (HP:0006846)3.03058506
14Neoplasm of the adrenal cortex (HP:0100641)2.99565654
15Retinal dysplasia (HP:0007973)2.98680893
16Abnormality of cells of the erythroid lineage (HP:0012130)2.97483852
17Abnormal number of erythroid precursors (HP:0012131)2.95940320
18Abnormality of glycolysis (HP:0004366)2.92875765
19Increased serum pyruvate (HP:0003542)2.92875765
20Progressive macrocephaly (HP:0004481)2.90120829
21Increased intramyocellular lipid droplets (HP:0012240)2.89129121
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.88793895
23Abnormal protein N-linked glycosylation (HP:0012347)2.88793895
24Abnormal protein glycosylation (HP:0012346)2.88793895
25Abnormal glycosylation (HP:0012345)2.88793895
26Patchy hypopigmentation of hair (HP:0011365)2.85620472
27Exertional dyspnea (HP:0002875)2.81760778
28Abnormality of secondary sexual hair (HP:0009888)2.74805128
29Abnormality of the axillary hair (HP:0100134)2.74805128
30Increased CSF lactate (HP:0002490)2.74326742
31Abnormality of the labia minora (HP:0012880)2.72303366
32Cerebral edema (HP:0002181)2.71864232
33Increased serum lactate (HP:0002151)2.70311534
34Sensory axonal neuropathy (HP:0003390)2.65398217
35Type I transferrin isoform profile (HP:0003642)2.64894644
36Abnormality of renal resorption (HP:0011038)2.64551146
37Lactic acidosis (HP:0003128)2.64322575
38Hypothermia (HP:0002045)2.64142892
39Vacuolated lymphocytes (HP:0001922)2.58683820
40Methylmalonic acidemia (HP:0002912)2.57917512
41Neurofibrillary tangles (HP:0002185)2.57571797
42Increased muscle lipid content (HP:0009058)2.57102141
43Pancreatic cysts (HP:0001737)2.56572349
44Gait imbalance (HP:0002141)2.54918524
45Congenital primary aphakia (HP:0007707)2.54601625
46White forelock (HP:0002211)2.53310758
47Molar tooth sign on MRI (HP:0002419)2.52318304
48Abnormality of midbrain morphology (HP:0002418)2.52318304
49Elevated erythrocyte sedimentation rate (HP:0003565)2.50553826
50Congenital ichthyosiform erythroderma (HP:0007431)2.45720920
51Neoplasm of the adrenal gland (HP:0100631)2.45663416
52Hyperalaninemia (HP:0003348)2.43080725
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43080725
54Abnormality of alanine metabolism (HP:0010916)2.43080725
55Absent thumb (HP:0009777)2.41068814
56Nephrogenic diabetes insipidus (HP:0009806)2.39461786
57Leukodystrophy (HP:0002415)2.38098015
58Pancreatic fibrosis (HP:0100732)2.35678467
59Nephronophthisis (HP:0000090)2.34478522
60Abnormality of the anterior horn cell (HP:0006802)2.32320768
61Degeneration of anterior horn cells (HP:0002398)2.32320768
62Petechiae (HP:0000967)2.31816904
63Renal cortical cysts (HP:0000803)2.30090774
64Abnormality of methionine metabolism (HP:0010901)2.28859438
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.27145188
66Lethargy (HP:0001254)2.27092948
67Methylmalonic aciduria (HP:0012120)2.26785002
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24543243
69Chromsome breakage (HP:0040012)2.24441089
70Hepatosplenomegaly (HP:0001433)2.24345647
71Abnormal hemoglobin (HP:0011902)2.24172810
72Abnormality of aromatic amino acid family metabolism (HP:0004338)2.23574335
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22569222
74Abnormality of chromosome stability (HP:0003220)2.18375972
75Cerebral hypomyelination (HP:0006808)2.17966805
76True hermaphroditism (HP:0010459)2.17813518
77Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17799903
78Chronic otitis media (HP:0000389)2.16990439
793-Methylglutaconic aciduria (HP:0003535)2.15610159
80Atrophy/Degeneration involving motor neurons (HP:0007373)2.15237785
81Thrombocytosis (HP:0001894)2.12543739
82Reticulocytopenia (HP:0001896)2.10569540
83Degeneration of the lateral corticospinal tracts (HP:0002314)2.10076545
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.10076545
85Abnormality of dentin (HP:0010299)2.09976422
86Meckel diverticulum (HP:0002245)2.09096692
87Abnormality of the preputium (HP:0100587)2.08484856
88Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06605138
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.06037062
90Progressive neurologic deterioration (HP:0002344)2.05930625
91Respiratory failure (HP:0002878)2.05076691
92Myositis (HP:0100614)2.03998092
93Purpura (HP:0000979)2.03431075
94Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03339562
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03339562
96Hypochromic microcytic anemia (HP:0004840)2.02486891
97Hypoplasia of the pons (HP:0012110)2.02235357
98Abnormality of the ileum (HP:0001549)1.99614214
99Abnormality of the pons (HP:0007361)1.99590429
100Hyperphosphaturia (HP:0003109)1.98910812
101Nonimmune hydrops fetalis (HP:0001790)1.98113013
102Abnormality of macular pigmentation (HP:0008002)1.97468284
103Stridor (HP:0010307)1.97359523
104Spastic paraparesis (HP:0002313)1.97212901
105Premature skin wrinkling (HP:0100678)1.96996933
106Anomalous pulmonary venous return (HP:0010772)1.94455802
107Aplastic anemia (HP:0001915)1.91133580
108Optic disc pallor (HP:0000543)1.90705854
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90182853
110CNS demyelination (HP:0007305)1.89847251
111Abnormality of the pulmonary veins (HP:0011718)1.89148430
112Abnormality of the heme biosynthetic pathway (HP:0010472)1.88939174
113Abnormal hair whorl (HP:0010721)1.88904864
114Reduced antithrombin III activity (HP:0001976)1.88065546
115Hyperglycinemia (HP:0002154)1.87323307
116Poor suck (HP:0002033)1.87267604
117Abnormality of serum amino acid levels (HP:0003112)1.85811423
118Abolished electroretinogram (ERG) (HP:0000550)1.84289405
119Polyphagia (HP:0002591)1.83731371
120Glycosuria (HP:0003076)1.82809140
121Abnormality of urine glucose concentration (HP:0011016)1.82809140
122Barrel-shaped chest (HP:0001552)1.82789281
123Neutropenia (HP:0001875)1.82392885
124Vaginal atresia (HP:0000148)1.81875966
125Genital tract atresia (HP:0001827)1.81719788
126Cerebral hemorrhage (HP:0001342)1.81382845
127Erythema (HP:0010783)1.80302451
128Abnormality of the fovea (HP:0000493)1.79137279
129Abnormality of the fetal cardiovascular system (HP:0010948)1.78291376
130Abnormal umbilical cord blood vessels (HP:0011403)1.78291376
131Single umbilical artery (HP:0001195)1.78291376
132Broad face (HP:0000283)1.76863057
133Congenital sensorineural hearing impairment (HP:0008527)1.76801094
134Abnormality of vitamin B metabolism (HP:0004340)1.76676122
135X-linked dominant inheritance (HP:0001423)1.76546866
136Macrocytic anemia (HP:0001972)1.76430162
137Exercise intolerance (HP:0003546)1.75831537
138Infantile muscular hypotonia (HP:0008947)1.75508815
139Large for gestational age (HP:0001520)1.73801261
140Neuroendocrine neoplasm (HP:0100634)1.73767346
141Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73041556
142Tongue fasciculations (HP:0001308)1.72870980
143Hypoplastic pelvis (HP:0008839)1.71780972
144Abnormality of the renal medulla (HP:0100957)1.71537502
145Respiratory difficulties (HP:0002880)1.71229935
146Anencephaly (HP:0002323)1.71145945
147Poor coordination (HP:0002370)1.70691468
148Cutaneous melanoma (HP:0012056)1.69326987
149Adrenal hypoplasia (HP:0000835)1.66483230
150Sclerocornea (HP:0000647)1.66047428
151Type II lissencephaly (HP:0007260)1.65955733
152Abnormality of the vitamin B12 metabolism (HP:0004341)1.65695228
153Abnormalities of placenta or umbilical cord (HP:0001194)1.65520028
154Aplasia/Hypoplasia of the fovea (HP:0008060)1.65473976
155Pancreatic islet-cell hyperplasia (HP:0004510)1.65363310
156Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.64599452
157Loss of speech (HP:0002371)1.63563829
158Nemaline bodies (HP:0003798)1.62996416
159Opisthotonus (HP:0002179)1.62451903
160Beaking of vertebral bodies (HP:0004568)1.60920070
161Poor head control (HP:0002421)1.60898541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.88426436
2TRIM283.71904392
3STK393.40210500
4MAP4K23.31270734
5STK163.26609981
6TIE13.19724431
7EPHB12.96224573
8TNIK2.77478757
9MAPK152.47509439
10OXSR12.46631788
11MAPKAPK52.45248515
12CDK192.43633104
13PBK2.35632213
14VRK22.19114289
15PIK3CG2.18840767
16TEC2.17556691
17BCKDK2.08414325
18MST42.04855429
19MUSK2.00247279
20EIF2AK11.96075951
21BCR1.84858785
22PLK31.83269361
23ERBB31.77122236
24VRK11.74075173
25BMPR1B1.68748948
26KIT1.68032536
27CLK11.63089406
28EIF2AK31.60155121
29WNK31.59584641
30BUB11.55633326
31PIM21.51648552
32PLK41.49057144
33PLK21.42016743
34FLT31.40282929
35SIK31.39832054
36MAP3K41.39356643
37CSNK1G31.39220744
38MAP2K71.38226803
39NME21.38044414
40ARAF1.35763041
41MYLK1.33415079
42NLK1.33009782
43GRK61.32931170
44PRPF4B1.32529770
45WNK41.30579862
46LIMK11.29502055
47IRAK41.27497153
48TRPM71.26080701
49MAP3K121.24468035
50SRPK11.18134140
51KDR1.16107241
52IRAK11.16073787
53MARK31.15882347
54DYRK31.14389524
55NEK11.14043606
56EPHA31.13562843
57CDC71.12799146
58CSNK1A1L1.11648191
59PASK1.07093781
60PLK11.06346209
61DYRK21.06146095
62CSNK1G11.04820685
63TLK11.01519448
64PAK31.00509425
65TESK20.98694351
66NME10.95458981
67WEE10.94404292
68RPS6KA50.94076842
69TAOK30.93216467
70ITK0.92540461
71SCYL20.89866678
72ADRBK20.89538609
73GRK10.87136975
74ILK0.85702642
75PDK20.84031262
76HIPK20.83987822
77MET0.83547364
78PKN10.83211958
79GRK50.82275214
80FGFR20.81879453
81ATR0.78467471
82UHMK10.78270823
83BRAF0.77644270
84CSNK1G20.77389859
85TBK10.76055462
86TXK0.75890780
87NEK60.75467184
88MAP3K60.74638452
89BRSK20.74584041
90EIF2AK20.73357107
91CASK0.73354869
92PINK10.71203770
93CAMK2B0.70932739
94MAPK130.69964121
95MAP3K20.69458855
96MAP3K130.68034569
97PIM10.67410249
98TGFBR10.67285658
99TGFBR20.65078246
100PRKCE0.63660591
101BTK0.62848366
102RPS6KA40.62505897
103TSSK60.61873437
104CAMK2D0.61251901
105MINK10.60232128
106LYN0.60107735
107ROCK20.60083920
108BRSK10.59579411
109CAMKK20.59073203
110PRKCI0.58332679
111LCK0.56871987
112TTK0.55015765
113PTK2B0.54573689
114CSF1R0.54072855
115DAPK10.53134097
116GRK70.52250260
117ATM0.52133413
118CCNB10.51531533
119ZAP700.51244104
120FER0.49675924
121ERN10.49298438
122NUAK10.48709649
123CSNK2A10.48106325
124RPS6KB20.47709141
125CSNK2A20.46969402
126FES0.46842317
127KSR10.46504211
128MARK10.43759980
129IRAK20.42995887
130YES10.42673704
131MAP4K10.42457420
132MKNK10.42319453
133MARK20.42023307
134JAK30.40159533
135ADRBK10.39638520
136PRKCQ0.39444658
137PRKCG0.39192360
138MAPKAPK20.39165209
139STK40.38518279
140CHEK20.38455809
141STK30.38298707
142MKNK20.37570444
143CDK80.35777654
144FGR0.35176946
145CSNK1A10.34613682
146ZAK0.34404172
147CAMK2G0.34382175
148PAK20.33606651
149RAF10.33372722
150IKBKB0.32730053
151WNK10.32691911
152TESK10.32477019
153ACVR1B0.31899710
154INSRR0.31616426
155MAP2K40.31614172

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.73003107
2Fatty acid elongation_Homo sapiens_hsa000623.87305876
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.47726249
4Steroid biosynthesis_Homo sapiens_hsa001003.25753186
5Ribosome_Homo sapiens_hsa030103.17341381
6Oxidative phosphorylation_Homo sapiens_hsa001902.79048249
7Sulfur metabolism_Homo sapiens_hsa009202.58812427
8Mismatch repair_Homo sapiens_hsa034302.42608437
9SNARE interactions in vesicular transport_Homo sapiens_hsa041302.40404569
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39515662
11Parkinsons disease_Homo sapiens_hsa050122.35257545
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.17895402
13* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13398081
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10545043
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09465811
16Base excision repair_Homo sapiens_hsa034102.05280583
17Ether lipid metabolism_Homo sapiens_hsa005652.00981327
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00194071
19Fanconi anemia pathway_Homo sapiens_hsa034601.96182066
20Caffeine metabolism_Homo sapiens_hsa002321.94108833
21Proteasome_Homo sapiens_hsa030501.92265319
22Sphingolipid metabolism_Homo sapiens_hsa006001.82516525
23Folate biosynthesis_Homo sapiens_hsa007901.81382810
24Alzheimers disease_Homo sapiens_hsa050101.72305521
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72265771
26Other glycan degradation_Homo sapiens_hsa005111.71426771
27Collecting duct acid secretion_Homo sapiens_hsa049661.63237969
28Huntingtons disease_Homo sapiens_hsa050161.56224904
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55794635
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51964247
31One carbon pool by folate_Homo sapiens_hsa006701.48555606
32Histidine metabolism_Homo sapiens_hsa003401.43566397
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41910351
34N-Glycan biosynthesis_Homo sapiens_hsa005101.38892845
35RNA polymerase_Homo sapiens_hsa030201.37045856
36Glutathione metabolism_Homo sapiens_hsa004801.31178820
37RNA transport_Homo sapiens_hsa030131.29876618
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29433458
39Selenocompound metabolism_Homo sapiens_hsa004501.28965759
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26439420
41Vibrio cholerae infection_Homo sapiens_hsa051101.26424419
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23520250
43Basal transcription factors_Homo sapiens_hsa030221.12352101
44Linoleic acid metabolism_Homo sapiens_hsa005911.09381457
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05794033
46Peroxisome_Homo sapiens_hsa041461.04513192
47Sulfur relay system_Homo sapiens_hsa041221.01214630
48Malaria_Homo sapiens_hsa051441.00591742
49Arachidonic acid metabolism_Homo sapiens_hsa005900.99678652
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98513408
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97739633
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96342208
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94322982
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89823761
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.88935343
56Cell cycle_Homo sapiens_hsa041100.84713692
57Lysosome_Homo sapiens_hsa041420.78485658
58Pyrimidine metabolism_Homo sapiens_hsa002400.77061244
59Non-homologous end-joining_Homo sapiens_hsa034500.74496941
60Rheumatoid arthritis_Homo sapiens_hsa053230.74337192
61p53 signaling pathway_Homo sapiens_hsa041150.73472469
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.70948716
63* Metabolic pathways_Homo sapiens_hsa011000.70318265
64Antigen processing and presentation_Homo sapiens_hsa046120.68473515
65Butanoate metabolism_Homo sapiens_hsa006500.68099172
66Cardiac muscle contraction_Homo sapiens_hsa042600.65847047
67Regulation of autophagy_Homo sapiens_hsa041400.64881935
68Tryptophan metabolism_Homo sapiens_hsa003800.61962394
69Purine metabolism_Homo sapiens_hsa002300.60270468
70Nitrogen metabolism_Homo sapiens_hsa009100.59414011
71beta-Alanine metabolism_Homo sapiens_hsa004100.59267270
72Fatty acid metabolism_Homo sapiens_hsa012120.58961965
73RNA degradation_Homo sapiens_hsa030180.58874974
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57835691
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57344473
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56563222
77Phagosome_Homo sapiens_hsa041450.56556102
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55287215
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55004503
80Primary immunodeficiency_Homo sapiens_hsa053400.54567387
81Chemical carcinogenesis_Homo sapiens_hsa052040.54002624
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53370052
83Retinol metabolism_Homo sapiens_hsa008300.52975876
84Graft-versus-host disease_Homo sapiens_hsa053320.52851519
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51576783
86Shigellosis_Homo sapiens_hsa051310.50870297
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50343993
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50174460
89Carbon metabolism_Homo sapiens_hsa012000.47428210
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47408052
91Allograft rejection_Homo sapiens_hsa053300.46826443
92Arginine and proline metabolism_Homo sapiens_hsa003300.45325193
93Oocyte meiosis_Homo sapiens_hsa041140.41768295
94Fatty acid degradation_Homo sapiens_hsa000710.41700577
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41662811
96Type I diabetes mellitus_Homo sapiens_hsa049400.41622494
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40918538
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.40829804
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39805194
100Hematopoietic cell lineage_Homo sapiens_hsa046400.38044416
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33360670
102Fat digestion and absorption_Homo sapiens_hsa049750.32460016
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32266505
104Spliceosome_Homo sapiens_hsa030400.32049721
105Autoimmune thyroid disease_Homo sapiens_hsa053200.31015072
106Phototransduction_Homo sapiens_hsa047440.30949734
107DNA replication_Homo sapiens_hsa030300.30715203
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29345195
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29012013
110Tyrosine metabolism_Homo sapiens_hsa003500.28210615
111Homologous recombination_Homo sapiens_hsa034400.26810095
112Endocytosis_Homo sapiens_hsa041440.25834335
113Synaptic vesicle cycle_Homo sapiens_hsa047210.25742868
114Pyruvate metabolism_Homo sapiens_hsa006200.25356007
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24085216
116Vitamin digestion and absorption_Homo sapiens_hsa049770.24030982
117Propanoate metabolism_Homo sapiens_hsa006400.23821226
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.23747236
119Biosynthesis of amino acids_Homo sapiens_hsa012300.22356123
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.22051382
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21549456
122Systemic lupus erythematosus_Homo sapiens_hsa053220.21445479
123Starch and sucrose metabolism_Homo sapiens_hsa005000.20816650
124Platelet activation_Homo sapiens_hsa046110.18473502
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.18010251
126Ovarian steroidogenesis_Homo sapiens_hsa049130.17968163
127Vitamin B6 metabolism_Homo sapiens_hsa007500.16617831
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16361386
129Renin-angiotensin system_Homo sapiens_hsa046140.16218390
130Cocaine addiction_Homo sapiens_hsa050300.15460956
131Alcoholism_Homo sapiens_hsa050340.15380880
132Ras signaling pathway_Homo sapiens_hsa040140.15137361
133ABC transporters_Homo sapiens_hsa020100.14961695
134Nucleotide excision repair_Homo sapiens_hsa034200.14960376

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