PIEZO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)6.93977559
2peripheral nervous system neuron development (GO:0048935)6.15105437
3negative regulation of dendrite morphogenesis (GO:0050774)5.97792469
4plasma membrane repair (GO:0001778)5.10593121
5negative regulation of protein activation cascade (GO:2000258)5.10010393
6neuronal action potential (GO:0019228)4.82299089
7negative regulation of complement activation (GO:0045916)4.74409949
8regulation of protein activation cascade (GO:2000257)4.70039620
9cell migration in hindbrain (GO:0021535)4.68566770
10negative regulation of fibrinolysis (GO:0051918)4.61684618
11regulation of complement activation (GO:0030449)4.59089221
12detection of temperature stimulus (GO:0016048)4.49361144
13retina vasculature morphogenesis in camera-type eye (GO:0061299)4.40356126
14behavioral response to pain (GO:0048266)4.29952538
15midgut development (GO:0007494)4.28059372
16retinal ganglion cell axon guidance (GO:0031290)4.27944945
17basement membrane organization (GO:0071711)4.21584779
18regulation of fibrinolysis (GO:0051917)4.10940442
19regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.05115100
20detection of temperature stimulus involved in sensory perception (GO:0050961)4.02990819
21detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.02990819
22negative regulation of calcium ion transport into cytosol (GO:0010523)4.01031096
23enteric nervous system development (GO:0048484)4.00117637
24negative regulation of dendrite development (GO:2000171)3.82823451
25sequestering of extracellular ligand from receptor (GO:0035581)3.81332729
26negative regulation of homotypic cell-cell adhesion (GO:0034111)3.76166331
27negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.76015949
28neuronal action potential propagation (GO:0019227)3.70639032
29artery development (GO:0060840)3.62863895
30glomerular basement membrane development (GO:0032836)3.60889238
31bundle of His cell to Purkinje myocyte communication (GO:0086069)3.57172970
32membrane depolarization during action potential (GO:0086010)3.57121823
33negative regulation of humoral immune response (GO:0002921)3.52690877
34nuclear pore complex assembly (GO:0051292)3.50844274
35glomerular visceral epithelial cell development (GO:0072015)3.50698864
36positive regulation of muscle hypertrophy (GO:0014742)3.46718149
37positive regulation of cardiac muscle hypertrophy (GO:0010613)3.46718149
38regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.46084284
39embryonic retina morphogenesis in camera-type eye (GO:0060059)3.39970799
40membrane budding (GO:0006900)3.38942045
41neuron fate specification (GO:0048665)3.33425292
42glomerulus development (GO:0032835)3.29063925
43organ induction (GO:0001759)3.27892236
44response to pain (GO:0048265)3.26660487
45intermediate filament cytoskeleton organization (GO:0045104)3.26513890
46intermediate filament-based process (GO:0045103)3.25038139
47lymphangiogenesis (GO:0001946)3.22935654
48innervation (GO:0060384)3.22803205
49positive regulation of developmental pigmentation (GO:0048087)3.17736200
50regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.16434586
51blood coagulation, intrinsic pathway (GO:0007597)3.15344868
52regulation of platelet aggregation (GO:0090330)3.14421068
53negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.14305459
54response to water (GO:0009415)3.13450880
55branching involved in prostate gland morphogenesis (GO:0060442)3.12150018
56endothelium development (GO:0003158)3.12027991
57intermediate filament organization (GO:0045109)3.11913411
58peptidyl-tyrosine autophosphorylation (GO:0038083)3.11468049
59cell communication involved in cardiac conduction (GO:0086065)3.11191277
60protein carboxylation (GO:0018214)3.10163704
61peptidyl-glutamic acid carboxylation (GO:0017187)3.10163704
62regulation of hippo signaling (GO:0035330)3.08451555
63protein targeting to plasma membrane (GO:0072661)3.08256589
64negative regulation of norepinephrine secretion (GO:0010700)3.07481563
65calcium-mediated signaling using intracellular calcium source (GO:0035584)3.07433514
66glomerular epithelial cell development (GO:0072310)3.07235676
67pericardium development (GO:0060039)3.03587662
68urinary tract smooth muscle contraction (GO:0014848)3.02108158
69neuron projection extension involved in neuron projection guidance (GO:1902284)3.02080925
70axon extension involved in axon guidance (GO:0048846)3.02080925
71establishment of apical/basal cell polarity (GO:0035089)3.01678920
72axon cargo transport (GO:0008088)3.00697431
73proline transport (GO:0015824)3.00561553
74lipid translocation (GO:0034204)2.99368047
75phospholipid translocation (GO:0045332)2.99368047
76regulation of pigment cell differentiation (GO:0050932)2.98678918
77cellular response to ethanol (GO:0071361)2.97683218
78embryonic foregut morphogenesis (GO:0048617)2.97238916
79urea metabolic process (GO:0019627)2.97030174
80negative regulation of osteoblast proliferation (GO:0033689)2.96876641
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96839188
82regulation of plasminogen activation (GO:0010755)2.95063680
83positive regulation of axon extension (GO:0045773)2.94917113
84renal filtration (GO:0097205)2.94161886
85urea cycle (GO:0000050)2.91719707
86high-density lipoprotein particle remodeling (GO:0034375)2.90534623
87endothelial cell morphogenesis (GO:0001886)2.90476771
88negative regulation of chondrocyte differentiation (GO:0032331)2.90347367
89mesenchymal-epithelial cell signaling (GO:0060638)2.89773435
90vascular endothelial growth factor signaling pathway (GO:0038084)2.87647984
91regulation of axon extension involved in axon guidance (GO:0048841)2.87108812
92paraxial mesoderm development (GO:0048339)2.86177750
93lung vasculature development (GO:0060426)2.85622891
94membrane repolarization (GO:0086009)2.85269508
95prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.85102646
96regulation of non-canonical Wnt signaling pathway (GO:2000050)2.83673070
97regulation of establishment of cell polarity (GO:2000114)2.83579399
98neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.82915262
99nuclear pore organization (GO:0006999)2.81228293
100positive regulation of hormone biosynthetic process (GO:0046886)2.80816563
101L-phenylalanine catabolic process (GO:0006559)2.80492065
102erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.80492065
103glomerular filtration (GO:0003094)2.79691527
104axon development (GO:0061564)2.79421546
105regulation of amyloid precursor protein catabolic process (GO:1902991)2.79380316
106positive regulation of glomerulus development (GO:0090193)2.79123914
107negative regulation of sodium ion transport (GO:0010766)2.78528208
108negative regulation of axon extension involved in axon guidance (GO:0048843)2.78498233
109chondrocyte proliferation (GO:0035988)2.78110848
110negative regulation of cation channel activity (GO:2001258)2.75360713
111very-low-density lipoprotein particle assembly (GO:0034379)2.74657155
112reverse cholesterol transport (GO:0043691)2.73181406
113sprouting angiogenesis (GO:0002040)2.72298503
114cerebellar Purkinje cell differentiation (GO:0021702)2.69962779
115action potential (GO:0001508)2.69946030
116endocardial cushion development (GO:0003197)2.69484475
117regulation of establishment or maintenance of cell polarity (GO:0032878)2.69275568
118axon extension (GO:0048675)2.68623889
119cytoskeletal anchoring at plasma membrane (GO:0007016)2.67829224
120peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.66814445
121mesenchymal cell differentiation (GO:0048762)2.66764830
122sodium ion transmembrane transport (GO:0035725)2.66269959
123respiratory tube development (GO:0030323)2.65836869
124metanephric mesenchyme development (GO:0072075)2.64623471
125hemidesmosome assembly (GO:0031581)2.63271181
126protein-lipid complex remodeling (GO:0034368)2.63225715
127macromolecular complex remodeling (GO:0034367)2.63225715
128plasma lipoprotein particle remodeling (GO:0034369)2.63225715
129complement activation, alternative pathway (GO:0006957)2.62975989
130potassium ion export (GO:0071435)2.62037746
131notochord development (GO:0030903)2.61481880
132negative regulation of platelet activation (GO:0010544)2.60530179
133regulation of apoptotic cell clearance (GO:2000425)2.59707615
134negative regulation of leukocyte chemotaxis (GO:0002689)2.58444096
135negative regulation of microtubule polymerization (GO:0031115)2.56888538
136regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.54366324
137insulin-like growth factor receptor signaling pathway (GO:0048009)2.54182108
138regulation of axon guidance (GO:1902667)2.54122184
139fibrinolysis (GO:0042730)2.53504492
140cholesterol efflux (GO:0033344)2.53466797
141regulation of steroid hormone biosynthetic process (GO:0090030)2.53345629
142positive regulation of cell size (GO:0045793)2.53219123
143cell adhesion mediated by integrin (GO:0033627)2.52896319
144hepatocyte differentiation (GO:0070365)2.51703125
145L-phenylalanine metabolic process (GO:0006558)2.51481560
146erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.51481560
147focal adhesion assembly (GO:0048041)2.51339458
148cell-substrate adherens junction assembly (GO:0007045)2.51339458
149regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.50064938
150hippo signaling (GO:0035329)2.49488519
151axon ensheathment in central nervous system (GO:0032291)2.49239007
152central nervous system myelination (GO:0022010)2.49239007
153regulation of cell communication by electrical coupling (GO:0010649)2.49177538
154regulation of humoral immune response (GO:0002920)2.48946771
155phasic smooth muscle contraction (GO:0014821)2.48911958
156negative regulation of DNA repair (GO:0045738)2.46708036
157positive regulation of potassium ion transmembrane transport (GO:1901381)2.46343870
158kidney mesenchyme development (GO:0072074)2.46070068
159purinergic nucleotide receptor signaling pathway (GO:0035590)2.45761380
160phospholipid scrambling (GO:0017121)2.45684155
161dicarboxylic acid biosynthetic process (GO:0043650)2.45667985
162vesicle transport along microtubule (GO:0047496)2.44865043
163axon regeneration (GO:0031103)2.44855314
164establishment of epithelial cell polarity (GO:0090162)2.44748781
165genitalia morphogenesis (GO:0035112)2.44518177
166positive regulation of axonogenesis (GO:0050772)2.44433567
167plasma lipoprotein particle assembly (GO:0034377)2.44246693
168intestinal cholesterol absorption (GO:0030299)2.44156202
169interkinetic nuclear migration (GO:0022027)2.43404928
170positive regulation of catenin import into nucleus (GO:0035413)2.42319105
171regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.41994326
172collagen fibril organization (GO:0030199)2.41724923
173lymph vessel development (GO:0001945)2.41415694
174adherens junction assembly (GO:0034333)2.41355086
175mesenchymal cell differentiation involved in renal system development (GO:2001012)2.41336611
176mesenchymal cell differentiation involved in kidney development (GO:0072161)2.41336611
177regulation of osteoblast proliferation (GO:0033688)2.41218631
178positive regulation of smooth muscle cell migration (GO:0014911)2.41025820
179establishment of monopolar cell polarity (GO:0061162)2.40878064
180establishment or maintenance of monopolar cell polarity (GO:0061339)2.40878064
181glutamate secretion (GO:0014047)2.40320898
182anterior/posterior axis specification, embryo (GO:0008595)2.39584121
183tyrosine metabolic process (GO:0006570)2.39122597
184substrate adhesion-dependent cell spreading (GO:0034446)2.39038709
185cell proliferation involved in metanephros development (GO:0072203)2.38877884
186negative regulation of lipase activity (GO:0060192)2.38864707
187positive regulation of potassium ion transport (GO:0043268)2.38187503
188regulation of cardiac muscle hypertrophy (GO:0010611)2.37569213
189synaptic vesicle maturation (GO:0016188)2.36703467
190cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.35714257
191regulation of cell maturation (GO:1903429)2.34002155
192regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.33513332
193organelle transport along microtubule (GO:0072384)2.32747852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human2.57902221
2EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53505185
3RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53505185
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52002386
5CDX2_19796622_ChIP-Seq_MESCs_Mouse2.49491902
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44169127
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39847165
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.33962473
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.33903016
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.30501449
11GBX2_23144817_ChIP-Seq_PC3_Human2.20809096
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.20532455
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19431673
14FOXA2_19822575_ChIP-Seq_HepG2_Human2.18299995
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15575988
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14748115
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14683160
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08690093
19TAF15_26573619_Chip-Seq_HEK293_Human2.05000766
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.04318890
21AHR_22903824_ChIP-Seq_MCF-7_Human2.02333517
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02318073
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99590989
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.99000012
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.98161023
26TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.94551640
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93765426
28CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.91266351
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89503412
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87117384
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84081739
32TP53_16413492_ChIP-PET_HCT116_Human1.82492899
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80486669
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78302984
35GATA1_22025678_ChIP-Seq_K562_Human1.78131992
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.76625998
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.74820042
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.74698255
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.73618069
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.72689588
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70804354
42CJUN_26792858_Chip-Seq_BT549_Human1.68496347
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68180655
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.67400890
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67010768
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.64722744
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.62436739
48ZNF263_19887448_ChIP-Seq_K562_Human1.61877794
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60961759
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59613880
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58459655
52E2F7_22180533_ChIP-Seq_HELA_Human1.58323732
53SMAD4_21799915_ChIP-Seq_A2780_Human1.57734854
54FUS_26573619_Chip-Seq_HEK293_Human1.55954267
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.55575810
56BRD4_25478319_ChIP-Seq_HGPS_Human1.54931072
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.54858164
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53700768
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51514974
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51148841
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45722602
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.45609544
63TP53_18474530_ChIP-ChIP_U2OS_Human1.43213791
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42949414
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42909010
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41381088
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40631721
68TBX3_20139965_ChIP-Seq_ESCs_Mouse1.40526203
69ISL1_27105846_Chip-Seq_CPCs_Mouse1.40398586
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40323083
71TBX3_20139965_ChIP-Seq_MESCs_Mouse1.39627162
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.39619096
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.37804301
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35463476
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.34109059
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.32859311
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32612251
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31149964
79FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29794366
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29320068
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28765261
82TCF4_18268006_ChIP-ChIP_LS174T_Human1.27877313
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27112625
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27088856
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26991196
86P300_19829295_ChIP-Seq_ESCs_Human1.26404812
87TCF4_23295773_ChIP-Seq_U87_Human1.26198475
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25764277
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25161546
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24930187
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.24758312
92HNF4A_19822575_ChIP-Seq_HepG2_Human1.24585475
93SOX9_26525672_Chip-Seq_HEART_Mouse1.22451374
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21992583
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21992583
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.21512069
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19396222
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19333847
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18874056
100AR_21572438_ChIP-Seq_LNCaP_Human1.18440710
101PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.17596623
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16731501
103SOX2_20726797_ChIP-Seq_SW620_Human1.16315290
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.16230162
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15002101
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.14430014
107SALL1_21062744_ChIP-ChIP_HESCs_Human1.14192657
108FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14039902
109EWS_26573619_Chip-Seq_HEK293_Human1.13486348
110KDM2B_26808549_Chip-Seq_K562_Human1.13115024
111CLOCK_20551151_ChIP-Seq_293T_Human1.12928671
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12584571
113KDM2B_26808549_Chip-Seq_REH_Human1.12221944
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11416196
115WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11162292
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10720777
117AR_21909140_ChIP-Seq_LNCAP_Human1.10193168
118ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09504500
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.09262380
120BCAT_22108803_ChIP-Seq_LS180_Human1.09049910
121CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08453252
122RUNX2_22187159_ChIP-Seq_PCA_Human1.08361664
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07621776
124EZH2_22144423_ChIP-Seq_EOC_Human1.07287251
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06128198
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05804283
127CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04530809
128STAT3_23295773_ChIP-Seq_U87_Human1.04104770
129YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04039084
130SMAD4_21741376_ChIP-Seq_HESCs_Human1.03451828
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02745314
132SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02745314
133AR_25329375_ChIP-Seq_VCAP_Human1.00381942
134EGR1_19032775_ChIP-ChIP_M12_Human0.99799537
135PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99446005
136RING1B_27294783_Chip-Seq_NPCs_Mouse0.99091188
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98723085
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97293185
139DROSHA_22980978_ChIP-Seq_HELA_Human0.96104584
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94774384
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.94743582
142SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94112166
143RING1B_27294783_Chip-Seq_ESCs_Mouse0.93405453
144PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93380784
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.93101687
146STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91161189
147ZNF274_21170338_ChIP-Seq_K562_Hela0.90848575
148TP63_23658742_ChIP-Seq_EP156T_Human0.89608418
149SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87448470
150LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86548028
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.86274269
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84936125
153P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83746059
154TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83420090
155AR_19668381_ChIP-Seq_PC3_Human0.82402133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception5.84418763
2MP0001968_abnormal_touch/_nociception4.57092801
3MP0002736_abnormal_nociception_after4.38544712
4MP0004858_abnormal_nervous_system4.09031883
5MP0001986_abnormal_taste_sensitivity3.23621318
6MP0002734_abnormal_mechanical_nocicepti3.12645591
7MP0002733_abnormal_thermal_nociception3.00489790
8MP0004270_analgesia2.97464045
9MP0005503_abnormal_tendon_morphology2.81924143
10MP0008438_abnormal_cutaneous_collagen2.81472936
11MP0006276_abnormal_autonomic_nervous2.69551690
12MP0004272_abnormal_basement_membrane2.58605831
13MP0006054_spinal_hemorrhage2.52901530
14MP0001970_abnormal_pain_threshold2.50703496
15MP0000013_abnormal_adipose_tissue2.37973303
16MP0003950_abnormal_plasma_membrane2.28572273
17MP0001299_abnormal_eye_distance/2.24956473
18MP0001270_distended_abdomen2.20487682
19MP0003183_abnormal_peptide_metabolism2.13965970
20MP0003941_abnormal_skin_development2.11500651
21MP0005275_abnormal_skin_tensile2.09327465
22MP0003868_abnormal_feces_composition2.05514046
23MP0005257_abnormal_intraocular_pressure1.96272003
24MP0000534_abnormal_ureter_morphology1.95936687
25MP0005408_hypopigmentation1.94564126
26MP0001915_intracranial_hemorrhage1.92032978
27MP0005167_abnormal_blood-brain_barrier1.91138166
28MP0002751_abnormal_autonomic_nervous1.87731440
29MP0008057_abnormal_DNA_replication1.84537775
30MP0002139_abnormal_hepatobiliary_system1.82652275
31MP0009697_abnormal_copulation1.80589768
32MP0002184_abnormal_innervation1.78878967
33MP0000537_abnormal_urethra_morphology1.77859396
34MP0003279_aneurysm1.77599555
35MP0003045_fibrosis1.73688191
36MP0001348_abnormal_lacrimal_gland1.73457551
37MP0009780_abnormal_chondrocyte_physiolo1.73138783
38MP0010368_abnormal_lymphatic_system1.71498250
39MP0005623_abnormal_meninges_morphology1.71179976
40MP0001958_emphysema1.51548803
41MP0003942_abnormal_urinary_system1.50094212
42MP0009250_abnormal_appendicular_skeleto1.48139195
43MP0000003_abnormal_adipose_tissue1.47898265
44MP0002138_abnormal_hepatobiliary_system1.45066434
45MP0003705_abnormal_hypodermis_morpholog1.43956780
46MP0000751_myopathy1.43802825
47MP0002163_abnormal_gland_morphology1.43114697
48MP0000749_muscle_degeneration1.33028417
49MP0010030_abnormal_orbit_morphology1.32216275
50MP0003115_abnormal_respiratory_system1.32214382
51MP0005085_abnormal_gallbladder_physiolo1.31540620
52MP0002697_abnormal_eye_size1.30424503
53MP0001879_abnormal_lymphatic_vessel1.29865374
54MP0001666_abnormal_nutrient_absorption1.27721832
55MP0000955_abnormal_spinal_cord1.27371380
56MP0001661_extended_life_span1.24327367
57MP0003252_abnormal_bile_duct1.24319130
58MP0003385_abnormal_body_wall1.23577454
59MP0002067_abnormal_sensory_capabilities1.22924182
60MP0000538_abnormal_urinary_bladder1.19230476
61MP0004134_abnormal_chest_morphology1.17734994
62MP0004147_increased_porphyrin_level1.17516347
63MP0001177_atelectasis1.17312832
64MP0004883_abnormal_blood_vessel1.13786459
65MP0002128_abnormal_blood_circulation1.12025677
66MP0003195_calcinosis1.09917471
67MP0004145_abnormal_muscle_electrophysio1.09892184
68MP0009379_abnormal_foot_pigmentation1.09785205
69MP0000613_abnormal_salivary_gland1.09284820
70MP0002089_abnormal_postnatal_growth/wei1.08749410
71MP0002108_abnormal_muscle_morphology1.08278376
72MP0003566_abnormal_cell_adhesion1.07853031
73MP0002896_abnormal_bone_mineralization1.06894660
74MP0005508_abnormal_skeleton_morphology1.04281182
75MP0002938_white_spotting1.04237332
76MP0003935_abnormal_craniofacial_develop1.00627477
77MP0003091_abnormal_cell_migration1.00212195
78MP0001346_abnormal_lacrimal_gland1.00171394
79MP0002233_abnormal_nose_morphology0.99904945
80MP0002272_abnormal_nervous_system0.99701392
81MP0000747_muscle_weakness0.99021418
82MP0000778_abnormal_nervous_system0.97963100
83MP0001614_abnormal_blood_vessel0.97951946
84MP0005187_abnormal_penis_morphology0.97930521
85MP0000428_abnormal_craniofacial_morphol0.97547968
86MP0004859_abnormal_synaptic_plasticity0.97486330
87MP0004811_abnormal_neuron_physiology0.97209295
88MP0000767_abnormal_smooth_muscle0.97148649
89MP0003300_gastrointestinal_ulcer0.96967900
90MP0003315_abnormal_perineum_morphology0.96951796
91MP0003943_abnormal_hepatobiliary_system0.96747865
92MP0005076_abnormal_cell_differentiation0.96632738
93MP0005409_darkened_coat_color0.96630350
94MP0002925_abnormal_cardiovascular_devel0.96589937
95MP0008260_abnormal_autophagy0.96333992
96MP0005395_other_phenotype0.95974161
97MP0002086_abnormal_extraembryonic_tissu0.95485362
98MP0005083_abnormal_biliary_tract0.95375970
99MP0005171_absent_coat_pigmentation0.94620752
100MP0003890_abnormal_embryonic-extraembry0.93919747
101MP0003984_embryonic_growth_retardation0.93495921
102MP0002088_abnormal_embryonic_growth/wei0.93260352
103MP0005365_abnormal_bile_salt0.93057448
104MP0000516_abnormal_urinary_system0.91635895
105MP0005367_renal/urinary_system_phenotyp0.91635895
106MP0000383_abnormal_hair_follicle0.90571911
107MP0000762_abnormal_tongue_morphology0.89845173
108MP0002084_abnormal_developmental_patter0.89475654
109MP0000733_abnormal_muscle_development0.87561282
110MP0003656_abnormal_erythrocyte_physiolo0.86372585
111MP0010234_abnormal_vibrissa_follicle0.85696960
112MP0000371_diluted_coat_color0.85687817
113MP0000566_synostosis0.83851868
114MP0002160_abnormal_reproductive_system0.83815563
115MP0009384_cardiac_valve_regurgitation0.83277030
116MP0009053_abnormal_anal_canal0.82917101
117MP0002109_abnormal_limb_morphology0.82829239
118MP0002168_other_aberrant_phenotype0.81357723
119MP0001672_abnormal_embryogenesis/_devel0.80801835
120MP0005380_embryogenesis_phenotype0.80801835
121MP0010307_abnormal_tumor_latency0.80747654
122MP0000163_abnormal_cartilage_morphology0.79828025
123MP0005220_abnormal_exocrine_pancreas0.79694464
124MP0002282_abnormal_trachea_morphology0.78529048
125MP0002115_abnormal_skeleton_extremities0.78424116
126MP0009703_decreased_birth_body0.78406261
127MP0002295_abnormal_pulmonary_circulatio0.78272472
128MP0000372_irregular_coat_pigmentation0.78096325
129MP0002092_abnormal_eye_morphology0.78004776
130MP0010352_gastrointestinal_tract_polyps0.77618913
131MP0003283_abnormal_digestive_organ0.76841528
132MP0000920_abnormal_myelination0.76263790
133MP0009672_abnormal_birth_weight0.75021461
134MP0002882_abnormal_neuron_morphology0.74876300
135MP0000427_abnormal_hair_cycle0.74430494
136MP0006138_congestive_heart_failure0.74286787
137MP0001286_abnormal_eye_development0.74270488
138MP0003632_abnormal_nervous_system0.72796760
139MP0003119_abnormal_digestive_system0.70770246
140MP0010771_integument_phenotype0.70701907
141MP0000462_abnormal_digestive_system0.70429309
142MP0003122_maternal_imprinting0.70160237
143MP0005595_abnormal_vascular_smooth0.69077897
144MP0003634_abnormal_glial_cell0.68596235
145MP0003937_abnormal_limbs/digits/tail_de0.68110611
146MP0002972_abnormal_cardiac_muscle0.67371943
147MP0000432_abnormal_head_morphology0.65898228
148MP0004036_abnormal_muscle_relaxation0.65011586
149MP0010386_abnormal_urinary_bladder0.64898028
150MP0001175_abnormal_lung_morphology0.64839566
151MP0002752_abnormal_somatic_nervous0.64410297
152MP0005379_endocrine/exocrine_gland_phen0.64370304
153MP0005360_urolithiasis0.63866179
154MP0004085_abnormal_heartbeat0.63671568
155MP0002932_abnormal_joint_morphology0.62538087
156MP0004084_abnormal_cardiac_muscle0.62386515
157MP0004484_altered_response_of0.58652226
158MP0000681_abnormal_thyroid_gland0.57763972
159MP0003635_abnormal_synaptic_transmissio0.57716196
160MP0005197_abnormal_uvea_morphology0.56963117
161MP0005023_abnormal_wound_healing0.55948874
162MP0000759_abnormal_skeletal_muscle0.55691813

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)7.99164981
2Segmental peripheral demyelination/remyelination (HP:0003481)5.03106194
3Action tremor (HP:0002345)4.63917974
4Termporal pattern (HP:0011008)4.60693761
5Insidious onset (HP:0003587)4.60693761
6Decreased number of large peripheral myelinated nerve fibers (HP:0003387)4.39384937
7Deep venous thrombosis (HP:0002625)4.09351592
8Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.92277024
9Peripheral hypomyelination (HP:0007182)3.72285958
10Abnormal hemoglobin (HP:0011902)3.64874474
11Pheochromocytoma (HP:0002666)3.64283621
12Steppage gait (HP:0003376)3.62131804
13Cerebral aneurysm (HP:0004944)3.55064346
14Neonatal short-limb short stature (HP:0008921)3.51562862
15Hammertoe (HP:0001765)3.47311299
16Metaphyseal dysplasia (HP:0100255)3.47275056
17Decreased motor nerve conduction velocity (HP:0003431)3.44327564
18Myokymia (HP:0002411)3.41598880
19Arterial tortuosity (HP:0005116)3.39402073
20Foot dorsiflexor weakness (HP:0009027)3.38099554
21Soft skin (HP:0000977)3.32727123
22Neuroendocrine neoplasm (HP:0100634)3.22103927
23Impaired pain sensation (HP:0007328)3.20628614
24Abnormality of pain sensation (HP:0010832)3.20628614
25Vascular tortuosity (HP:0004948)3.15857108
26Scanning speech (HP:0002168)3.13443235
27Hypobetalipoproteinemia (HP:0003563)3.12181045
28Abnormality of the foot musculature (HP:0001436)2.95884453
29Onion bulb formation (HP:0003383)2.93207835
30Hyporeflexia of lower limbs (HP:0002600)2.90308796
31Popliteal pterygium (HP:0009756)2.90174010
32Mitral valve prolapse (HP:0001634)2.74379255
33Mild short stature (HP:0003502)2.70179161
34Protrusio acetabuli (HP:0003179)2.65689218
35Myotonia (HP:0002486)2.65682171
36Prolonged partial thromboplastin time (HP:0003645)2.64499021
37Alacrima (HP:0000522)2.61390208
38Abnormality of dentin (HP:0010299)2.59491936
39Facial shape deformation (HP:0011334)2.56206926
40Potter facies (HP:0002009)2.56206926
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.53549452
42Vertebral arch anomaly (HP:0008438)2.53421758
43Abnormality of the common coagulation pathway (HP:0010990)2.53401864
44Short chin (HP:0000331)2.53029926
45Premature rupture of membranes (HP:0001788)2.52953573
46Midline defect of the nose (HP:0004122)2.51263321
47* Wide anterior fontanel (HP:0000260)2.47466042
48Febrile seizures (HP:0002373)2.47372683
49Complement deficiency (HP:0004431)2.45937752
50Decreased lacrimation (HP:0000633)2.40399107
51Broad metatarsal (HP:0001783)2.39949159
52Aortic aneurysm (HP:0004942)2.36668808
53Atonic seizures (HP:0010819)2.35353689
54Impaired proprioception (HP:0010831)2.33193749
55Abnormal delivery (HP:0001787)2.33175631
56Dysautonomia (HP:0002459)2.31566786
57Bowel diverticulosis (HP:0005222)2.30511783
58Distal sensory impairment (HP:0002936)2.28793191
59Mitral stenosis (HP:0001718)2.27298124
60Asymmetry of the thorax (HP:0001555)2.23509319
61Thyroid carcinoma (HP:0002890)2.22567291
62Flat acetabular roof (HP:0003180)2.20205503
63Vitreoretinal degeneration (HP:0000655)2.19978721
64Renovascular hypertension (HP:0100817)2.17687395
65Neoplasm of the peripheral nervous system (HP:0100007)2.16838738
66Aplasia involving bones of the extremities (HP:0009825)2.16813489
67Aplasia involving bones of the upper limbs (HP:0009823)2.16813489
68Aplasia of the phalanges of the hand (HP:0009802)2.16813489
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.16726643
70Osteolytic defects of the hand bones (HP:0009699)2.16726643
71Abnormality of incisor morphology (HP:0011063)2.16105409
72Atrophic scars (HP:0001075)2.16026194
73Hypoplasia of the iris (HP:0007676)2.15881026
74Distal lower limb muscle weakness (HP:0009053)2.15799643
75Neonatal respiratory distress (HP:0002643)2.15417931
76Postural tremor (HP:0002174)2.14940875
77Abnormality of the lumbar spine (HP:0100712)2.14756786
78Hypoventilation (HP:0002791)2.12349590
79Hypercortisolism (HP:0001578)2.12269338
80Bradycardia (HP:0001662)2.09288382
81Blue sclerae (HP:0000592)2.07651243
82Abnormality of the nasal septum (HP:0000419)2.07017896
83Cholecystitis (HP:0001082)2.05817637
84Abnormal gallbladder physiology (HP:0012438)2.05817637
85Peritonitis (HP:0002586)2.05096337
86Ulnar bowing (HP:0003031)2.04350047
87Ovoid vertebral bodies (HP:0003300)2.03493975
88Abnormality of the acetabulum (HP:0003170)2.01184339
89Morphological abnormality of the middle ear (HP:0008609)2.00839619
90Hypolipoproteinemia (HP:0010981)2.00818487
91Broad palm (HP:0001169)2.00581728
92Progressive cerebellar ataxia (HP:0002073)2.00242435
93Hypothermia (HP:0002045)2.00060217
94Aqueductal stenosis (HP:0002410)1.98021014
95Hypoplastic scapulae (HP:0000882)1.97662741
96Aplasia/Hypoplasia of the scapulae (HP:0006713)1.97662741
97Overgrowth (HP:0001548)1.96077325
98Upper limb muscle weakness (HP:0003484)1.95121650
99Failure to thrive in infancy (HP:0001531)1.94728950
100Hypoplastic ischia (HP:0003175)1.93030867
101Increased connective tissue (HP:0009025)1.91372626
102Bronchomalacia (HP:0002780)1.91135039
103Bladder diverticulum (HP:0000015)1.89933853
104Wormian bones (HP:0002645)1.89256214
105Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.89147884
106Esophageal varix (HP:0002040)1.88897488
107Abnormality of the vocal cords (HP:0008777)1.88003227
108Wrist flexion contracture (HP:0001239)1.87678709
109Bicornuate uterus (HP:0000813)1.87676364
110Renal duplication (HP:0000075)1.87425639
111* Thoracolumbar scoliosis (HP:0002944)1.87354115
112Abnormality of the intrinsic pathway (HP:0010989)1.85945261
113Dysmetric saccades (HP:0000641)1.85462069
114Lymphangioma (HP:0100764)1.85138650
115Aortic dissection (HP:0002647)1.84330835
116Abnormality of complement system (HP:0005339)1.83841743
117Focal seizures (HP:0007359)1.82217427
118Bilateral microphthalmos (HP:0007633)1.81506986
119Increased CSF protein (HP:0002922)1.80541852
120Abnormality of the ischium (HP:0003174)1.79410871
121Short 4th metacarpal (HP:0010044)1.78561086
122Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78561086
123Joint hemorrhage (HP:0005261)1.78527659
124* Cutaneous syndactyly (HP:0012725)1.78363337
125Abnormality of the peritoneum (HP:0002585)1.78222234
126Absent eyebrow (HP:0002223)1.77970015
127Abnormality of magnesium homeostasis (HP:0004921)1.77488129
128Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.77438612
129Abnormality of femoral epiphyses (HP:0006499)1.77438612
130Subacute progressive viral hepatitis (HP:0006572)1.76884629
131Natal tooth (HP:0000695)1.76552378
132Mesomelia (HP:0003027)1.76176965
133* Cutaneous finger syndactyly (HP:0010554)1.75729538
134Hypomagnesemia (HP:0002917)1.75359144
135Pterygium (HP:0001059)1.75129351
136* Camptodactyly of toe (HP:0001836)1.75027903
137Long toe (HP:0010511)1.73678700
138Abnormality of the calcaneus (HP:0008364)1.73508594
139Capillary hemangiomas (HP:0005306)1.73368163
140Nonimmune hydrops fetalis (HP:0001790)1.72953743
141Limited elbow extension (HP:0001377)1.71368674
142Synostosis of carpal bones (HP:0005048)1.70492099
143Hyperextensible skin (HP:0000974)1.70366588
144Delayed closure of the anterior fontanelle (HP:0001476)1.69842424
145Skull defect (HP:0001362)1.69537500
146Abnormality of the epiphysis of the femoral head (HP:0010574)1.68065170
147Fragile skin (HP:0001030)1.67252006
148Dilatation of the ascending aorta (HP:0005111)1.66901030
149Shallow orbits (HP:0000586)1.66415430
150Broad ribs (HP:0000885)1.66191474
151* Limited hip movement (HP:0008800)1.65207864
152Abnormality of the lacrimal duct (HP:0011481)1.65197969
153Abnormality of the costochondral junction (HP:0000919)1.65083341
154Calcaneovalgus deformity (HP:0001848)1.64984586
155Hemangiomatosis (HP:0007461)1.64964659
156J-shaped sella turcica (HP:0002680)1.64222945
157Spinal rigidity (HP:0003306)1.64148145
158Narrow palate (HP:0000189)1.64124500
159Aneurysm (HP:0002617)1.63932179
160Beaking of vertebral bodies (HP:0004568)1.63779934
161Thin ribs (HP:0000883)1.63503692
162Short hallux (HP:0010109)1.63119123
163Advanced eruption of teeth (HP:0006288)1.62896922
164Blue irides (HP:0000635)1.62703206
165Narrow nasal bridge (HP:0000446)1.62383787
166Portal hypertension (HP:0001409)1.62334323
167Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.62199823
168Diastasis recti (HP:0001540)1.62111564
169Menorrhagia (HP:0000132)1.61789779
170Areflexia of lower limbs (HP:0002522)1.61728498
171Exotropia (HP:0000577)1.61404313
172Supranuclear gaze palsy (HP:0000605)1.61165174
173Aplasia/Hypoplasia of the hallux (HP:0008362)1.60398967
174Cervical subluxation (HP:0003308)1.59811990
175Venous insufficiency (HP:0005293)1.59607877
176Anteriorly placed anus (HP:0001545)1.59391953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.38632899
2STK393.88021822
3LATS23.68599250
4LIMK13.03544451
5MAP3K23.00514180
6NTRK12.70169651
7FRK2.67233910
8RET2.45174795
9CDK122.44861258
10KSR22.34822949
11MINK12.32446622
12NTRK32.31418059
13FER2.26649581
14PTK2B2.20191861
15EPHA32.14051754
16EEF2K2.13189899
17MAPKAPK32.12010014
18PDK21.96617686
19MAP3K91.95592790
20AKT31.91964183
21EPHB21.91312201
22MELK1.76666310
23GRK51.75613164
24WNK11.69816953
25PHKG21.66784880
26PHKG11.66784880
27BRD41.57631895
28MKNK11.54603854
29WNK41.53179111
30TNIK1.52942745
31MKNK21.50086344
32TGFBR21.45464050
33BMPR1B1.44697540
34NEK91.40947061
35SCYL21.39490555
36ICK1.35867905
37LATS11.33182613
38INSRR1.30950765
39BRSK21.30149389
40TYRO31.28524903
41CAMK1G1.27292918
42TESK11.25388039
43FGFR11.22081189
44RPS6KA21.20962138
45TGFBR11.20450041
46DDR21.19972176
47OXSR11.16090563
48MAP2K11.14010164
49ACVR1B1.13879966
50PIK3CG1.13301232
51MAPKAPK51.12236967
52PDGFRA1.11467774
53CASK1.08483549
54FGFR31.07287325
55TIE11.05891594
56PTK21.04753131
57STK31.03895212
58MST1R1.02972773
59PBK0.96928688
60CDC70.95726682
61EPHB10.95487875
62MTOR0.94333294
63MAPK110.93739564
64MAP2K20.93200336
65PKN20.90936887
66MAP3K10.89791550
67PAK20.88415213
68BCR0.87769570
69LRRK20.84929855
70FGFR20.84736378
71ROCK10.84639753
72PRKG20.83865884
73ERBB40.82853784
74SGK20.79850387
75EIF2AK30.79594981
76SGK2230.78186980
77SGK4940.78186980
78PAK60.77245564
79TTN0.76417493
80CDK80.76220437
81MAP3K40.74712253
82MST40.74009846
83MATK0.73841618
84ROCK20.73064876
85MAP2K40.71073107
86ADRBK10.70788526
87FLT30.69627859
88NME10.69154344
89TTK0.69088226
90ARAF0.68522715
91PRKAA20.68408036
92MARK30.67946063
93MAPK130.66754910
94SGK30.66264884
95KDR0.65653227
96PAK30.64777688
97JAK10.64637921
98PIK3CA0.63225175
99PNCK0.62343286
100TNK20.62017057
101MAPK100.58882959
102CAMKK20.58795455
103RPS6KB20.57602227
104MAP3K120.57198767
105PRKCE0.56106751
106PLK30.53915412
107CAMK1D0.53811884
108CDK50.53391071
109ATM0.52986910
110CDK140.51589723
111NEK10.50607740
112CSNK1D0.50568386
113NEK20.48464352
114STK38L0.47598627
115PRKDC0.46323406
116PDPK10.46033214
117CDK60.45933455
118MAPK40.45717657
119CDK30.45008849
120TRPM70.44828081
121PLK20.44717947
122SGK10.44618887
123MAP2K70.44158382
124CDC42BPA0.43880437
125TESK20.43868240
126CSNK1A1L0.43866079
127PRKCH0.42748661
128RPS6KB10.42163758
129SIK30.42130389
130TLK10.41417486
131CAMK2D0.41114370
132MYLK0.41011205
133TAF10.41008630
134CHEK10.40649011
135MAP4K20.40177235
136PRKD10.40075490
137SRC0.38885862
138CAMKK10.37117985
139PDK10.36680655
140NLK0.35141137
141MET0.34811421
142PDGFRB0.34429088
143DAPK20.34316047
144SIK10.34181245
145INSR0.33690791
146PIM20.32741429
147MAPK10.32478255
148FGFR40.31422362
149ERN10.29314860
150RIPK10.27782232
151IGF1R0.26470958
152MAP3K70.25942725
153PINK10.24801090
154PTK60.24511983
155PRKACB0.24388330

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.16188435
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.33437345
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.64295044
4Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.47159618
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.46722168
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.15806169
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.15637156
8ECM-receptor interaction_Homo sapiens_hsa045122.06297060
9ABC transporters_Homo sapiens_hsa020101.99202569
10Dorso-ventral axis formation_Homo sapiens_hsa043201.96500024
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.94093442
12Synaptic vesicle cycle_Homo sapiens_hsa047211.93536898
13Lysine degradation_Homo sapiens_hsa003101.88384006
14Taste transduction_Homo sapiens_hsa047421.81736127
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.80731837
16Thyroid cancer_Homo sapiens_hsa052161.80129883
17Arginine biosynthesis_Homo sapiens_hsa002201.64487209
18Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.64336427
19Protein digestion and absorption_Homo sapiens_hsa049741.55779987
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53106697
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52842961
22Renin-angiotensin system_Homo sapiens_hsa046141.52116070
23Melanoma_Homo sapiens_hsa052181.51354093
24Hedgehog signaling pathway_Homo sapiens_hsa043401.50990867
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47539131
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.44738908
27Bile secretion_Homo sapiens_hsa049761.44640498
28Focal adhesion_Homo sapiens_hsa045101.39528421
29Endometrial cancer_Homo sapiens_hsa052131.38105861
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37404795
31Retinol metabolism_Homo sapiens_hsa008301.37354970
32Axon guidance_Homo sapiens_hsa043601.36754859
33Adherens junction_Homo sapiens_hsa045201.34046760
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33295631
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.27233475
36Glioma_Homo sapiens_hsa052141.27192581
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23163196
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20400430
39N-Glycan biosynthesis_Homo sapiens_hsa005101.18137673
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17380311
41Gap junction_Homo sapiens_hsa045401.16207652
42Amoebiasis_Homo sapiens_hsa051461.16192916
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.15603736
44Salmonella infection_Homo sapiens_hsa051321.13107146
45Histidine metabolism_Homo sapiens_hsa003401.12785468
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11990432
47Hippo signaling pathway_Homo sapiens_hsa043901.11072720
48Salivary secretion_Homo sapiens_hsa049701.10047091
49Chemical carcinogenesis_Homo sapiens_hsa052041.09600560
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.08865847
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08785431
52Rap1 signaling pathway_Homo sapiens_hsa040151.07995520
53Butanoate metabolism_Homo sapiens_hsa006501.07862472
54Non-homologous end-joining_Homo sapiens_hsa034501.07466726
55Fatty acid degradation_Homo sapiens_hsa000711.06658403
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06629105
57MicroRNAs in cancer_Homo sapiens_hsa052061.06360948
58TGF-beta signaling pathway_Homo sapiens_hsa043501.05656475
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05650896
60Insulin signaling pathway_Homo sapiens_hsa049101.04186864
61Insulin secretion_Homo sapiens_hsa049111.03777822
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03352391
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03309842
64PI3K-Akt signaling pathway_Homo sapiens_hsa041511.03032444
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02145489
66Vibrio cholerae infection_Homo sapiens_hsa051101.01965518
67Type II diabetes mellitus_Homo sapiens_hsa049300.99273456
68Proteoglycans in cancer_Homo sapiens_hsa052050.98308793
69ErbB signaling pathway_Homo sapiens_hsa040120.96303352
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96130973
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96099242
72Endocytosis_Homo sapiens_hsa041440.95765822
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95658585
74Prostate cancer_Homo sapiens_hsa052150.95167006
75Thyroid hormone synthesis_Homo sapiens_hsa049180.94752917
76Tight junction_Homo sapiens_hsa045300.93877247
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92829593
78Selenocompound metabolism_Homo sapiens_hsa004500.92400728
79Melanogenesis_Homo sapiens_hsa049160.92044127
80Bladder cancer_Homo sapiens_hsa052190.91841207
81Vitamin B6 metabolism_Homo sapiens_hsa007500.91093642
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89074261
83Olfactory transduction_Homo sapiens_hsa047400.88530452
84Cholinergic synapse_Homo sapiens_hsa047250.87172554
85Basal cell carcinoma_Homo sapiens_hsa052170.86166334
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85917074
87Dilated cardiomyopathy_Homo sapiens_hsa054140.85121278
88Prolactin signaling pathway_Homo sapiens_hsa049170.84965120
89Starch and sucrose metabolism_Homo sapiens_hsa005000.84858692
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84682139
91Phagosome_Homo sapiens_hsa041450.83608670
92Estrogen signaling pathway_Homo sapiens_hsa049150.78691460
93Mineral absorption_Homo sapiens_hsa049780.78060073
94Pathways in cancer_Homo sapiens_hsa052000.78028562
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.77955949
96Dopaminergic synapse_Homo sapiens_hsa047280.77118091
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76612739
98Ras signaling pathway_Homo sapiens_hsa040140.76586674
99VEGF signaling pathway_Homo sapiens_hsa043700.76008524
100Platelet activation_Homo sapiens_hsa046110.75585980
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75234204
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75040368
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74621429
104Tyrosine metabolism_Homo sapiens_hsa003500.74200658
105GnRH signaling pathway_Homo sapiens_hsa049120.73882979
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73537515
107Fatty acid biosynthesis_Homo sapiens_hsa000610.73423952
108Chronic myeloid leukemia_Homo sapiens_hsa052200.68135148
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67987981
110mTOR signaling pathway_Homo sapiens_hsa041500.66917773
111Choline metabolism in cancer_Homo sapiens_hsa052310.66731120
112beta-Alanine metabolism_Homo sapiens_hsa004100.66339348
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63765068
114One carbon pool by folate_Homo sapiens_hsa006700.63633892
115Vitamin digestion and absorption_Homo sapiens_hsa049770.63553049
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62701610
117Biosynthesis of amino acids_Homo sapiens_hsa012300.62675361
118MAPK signaling pathway_Homo sapiens_hsa040100.61754841
119Propanoate metabolism_Homo sapiens_hsa006400.61658954
120Tryptophan metabolism_Homo sapiens_hsa003800.61554678
121Gastric acid secretion_Homo sapiens_hsa049710.61144396
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.61130103
123HIF-1 signaling pathway_Homo sapiens_hsa040660.60669096
124Colorectal cancer_Homo sapiens_hsa052100.60400846
125Nitrogen metabolism_Homo sapiens_hsa009100.60384764
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60258749
127Renin secretion_Homo sapiens_hsa049240.60049443
128Pancreatic secretion_Homo sapiens_hsa049720.59676710
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.59586101
130Fatty acid metabolism_Homo sapiens_hsa012120.58645366
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57857115
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57725265
133Collecting duct acid secretion_Homo sapiens_hsa049660.57136975
134Cardiac muscle contraction_Homo sapiens_hsa042600.56425744
135Pancreatic cancer_Homo sapiens_hsa052120.55959236
136Wnt signaling pathway_Homo sapiens_hsa043100.55448749
137Long-term potentiation_Homo sapiens_hsa047200.55105193
138Glutamatergic synapse_Homo sapiens_hsa047240.55012145
139Fat digestion and absorption_Homo sapiens_hsa049750.54981279
140Steroid biosynthesis_Homo sapiens_hsa001000.54712040
141Oxytocin signaling pathway_Homo sapiens_hsa049210.54491578
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.54294721
143Toxoplasmosis_Homo sapiens_hsa051450.53804179
144Glucagon signaling pathway_Homo sapiens_hsa049220.53313991
145Prion diseases_Homo sapiens_hsa050200.52958784
146Circadian entrainment_Homo sapiens_hsa047130.52843940
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51292848
148Inositol phosphate metabolism_Homo sapiens_hsa005620.50954893
149Phenylalanine metabolism_Homo sapiens_hsa003600.50318537
150cAMP signaling pathway_Homo sapiens_hsa040240.49499072
151PPAR signaling pathway_Homo sapiens_hsa033200.49425074
152Small cell lung cancer_Homo sapiens_hsa052220.48023844
153Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47531281
154Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45986608

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