PID1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.07003538
2positive regulation by symbiont of host defense response (GO:0052509)4.88657380
3modulation by symbiont of host defense response (GO:0052031)4.88657380
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.88657380
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.88657380
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.88657380
7modulation by symbiont of host immune response (GO:0052553)4.88657380
8complement activation, alternative pathway (GO:0006957)4.56333270
9L-phenylalanine catabolic process (GO:0006559)4.53022665
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.53022665
11aromatic amino acid family catabolic process (GO:0009074)4.43075251
12plasma lipoprotein particle clearance (GO:0034381)4.37041797
13peptidyl-glutamic acid carboxylation (GO:0017187)4.36284316
14protein carboxylation (GO:0018214)4.36284316
15tryptophan catabolic process (GO:0006569)4.29142328
16indole-containing compound catabolic process (GO:0042436)4.29142328
17indolalkylamine catabolic process (GO:0046218)4.29142328
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.19931841
19L-phenylalanine metabolic process (GO:0006558)4.19931841
20bile acid biosynthetic process (GO:0006699)4.19154885
21urea cycle (GO:0000050)4.14653924
22urea metabolic process (GO:0019627)4.14653924
23regulation of protein activation cascade (GO:2000257)4.08383902
24positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.08192734
25tryptophan metabolic process (GO:0006568)4.07309895
26kynurenine metabolic process (GO:0070189)4.00580268
27high-density lipoprotein particle remodeling (GO:0034375)3.97939675
28reverse cholesterol transport (GO:0043691)3.96827364
29phospholipid efflux (GO:0033700)3.93172332
30regulation of complement activation (GO:0030449)3.84633436
31alpha-linolenic acid metabolic process (GO:0036109)3.84245387
32regulation of mononuclear cell migration (GO:0071675)3.80667777
33regulation of fibrinolysis (GO:0051917)3.77921003
34negative regulation of fibrinolysis (GO:0051918)3.75892335
35nitrogen cycle metabolic process (GO:0071941)3.73891862
36plasma lipoprotein particle remodeling (GO:0034369)3.69805047
37protein-lipid complex remodeling (GO:0034368)3.69805047
38macromolecular complex remodeling (GO:0034367)3.69805047
39positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.68526847
40cholesterol efflux (GO:0033344)3.65346985
41cysteine metabolic process (GO:0006534)3.61367923
42regulation of cholesterol esterification (GO:0010872)3.60435703
43positive regulation of cellular amide metabolic process (GO:0034250)3.59461362
44regulation of cholesterol storage (GO:0010885)3.57454432
45phospholipid homeostasis (GO:0055091)3.56547650
46pyrimidine nucleobase catabolic process (GO:0006208)3.55030582
47regulation of macrophage chemotaxis (GO:0010758)3.54334198
48bile acid metabolic process (GO:0008206)3.52562006
49regulation of triglyceride catabolic process (GO:0010896)3.51995790
50macrophage activation involved in immune response (GO:0002281)3.46643306
51glyoxylate metabolic process (GO:0046487)3.45221159
52regulation of interferon-beta biosynthetic process (GO:0045357)3.43469804
53negative regulation of interleukin-12 production (GO:0032695)3.42799953
54aldehyde catabolic process (GO:0046185)3.42352178
55fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.40152465
56response to peptidoglycan (GO:0032494)3.35948285
57cellular response to ethanol (GO:0071361)3.35580091
58hydrogen peroxide biosynthetic process (GO:0050665)3.35467001
59positive regulation of interferon-alpha production (GO:0032727)3.32180935
60barbed-end actin filament capping (GO:0051016)3.31637209
61sulfur amino acid catabolic process (GO:0000098)3.28962905
62homocysteine metabolic process (GO:0050667)3.28332971
63low-density lipoprotein particle remodeling (GO:0034374)3.26277782
64response to host immune response (GO:0052572)3.25533854
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25533854
66fibrinolysis (GO:0042730)3.24200659
67cellular response to zinc ion (GO:0071294)3.22945938
68low-density lipoprotein particle clearance (GO:0034383)3.20839517
69positive regulation of lipid catabolic process (GO:0050996)3.20709032
70plasma lipoprotein particle assembly (GO:0034377)3.18224008
71negative regulation of cholesterol transport (GO:0032375)3.17080208
72negative regulation of sterol transport (GO:0032372)3.17080208
73regulation of interferon-alpha production (GO:0032647)3.13329424
74tyrosine metabolic process (GO:0006570)3.12178513
75positive regulation of coagulation (GO:0050820)3.11321353
76triglyceride homeostasis (GO:0070328)3.11124145
77acylglycerol homeostasis (GO:0055090)3.11124145
78microglial cell activation (GO:0001774)3.10813165
79cellular glucuronidation (GO:0052695)3.10787059
80detection of molecule of bacterial origin (GO:0032490)3.06063762
81cellular response to cadmium ion (GO:0071276)3.05968945
82plasma lipoprotein particle organization (GO:0071827)3.04798622
83positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.04774526
84aromatic amino acid family metabolic process (GO:0009072)3.04180634
85indolalkylamine metabolic process (GO:0006586)3.02763166
86protein localization to endosome (GO:0036010)3.01331587
87uronic acid metabolic process (GO:0006063)3.00722219
88glucuronate metabolic process (GO:0019585)3.00722219
89cellular biogenic amine catabolic process (GO:0042402)2.98062311
90amine catabolic process (GO:0009310)2.98062311
91complement activation (GO:0006956)2.97370077
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.97297845
93protein activation cascade (GO:0072376)2.96169280
94positive regulation of hemostasis (GO:1900048)2.95508232
95positive regulation of blood coagulation (GO:0030194)2.95508232
96cofactor catabolic process (GO:0051187)2.93468398
97virion attachment to host cell (GO:0019062)2.92996886
98adhesion of symbiont to host cell (GO:0044650)2.92996886
99lipoprotein metabolic process (GO:0042157)2.91779128
100dicarboxylic acid biosynthetic process (GO:0043650)2.91387748
101acute-phase response (GO:0006953)2.91000493
102neutrophil activation involved in immune response (GO:0002283)2.90845166
103protein-lipid complex subunit organization (GO:0071825)2.87750581
104protein-lipid complex assembly (GO:0065005)2.87371785
105complement activation, classical pathway (GO:0006958)2.85872134
106response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.85459182
107response to host (GO:0075136)2.85459182
108response to host defenses (GO:0052200)2.85459182
109chondroitin sulfate catabolic process (GO:0030207)2.85291184
110reactive oxygen species biosynthetic process (GO:1903409)2.84972168
111serine family amino acid catabolic process (GO:0009071)2.83766006
112regulation of membrane protein ectodomain proteolysis (GO:0051043)2.79382818
113nucleobase catabolic process (GO:0046113)2.77604053
114positive regulation of heat generation (GO:0031652)2.75658899
115regulation of fever generation (GO:0031620)2.73261563
116amino acid import (GO:0043090)2.71275226
117lipopolysaccharide-mediated signaling pathway (GO:0031663)2.69131881
118regulation of vitamin D biosynthetic process (GO:0060556)2.68800026
119cellular response to thyroid hormone stimulus (GO:0097067)2.66432156
120omega-hydroxylase P450 pathway (GO:0097267)2.64945298
121L-amino acid import (GO:0043092)2.63559786
122epoxygenase P450 pathway (GO:0019373)2.59641058
123positive regulation of chemokine biosynthetic process (GO:0045080)2.57182033
124glycosphingolipid catabolic process (GO:0046479)2.56368340
125regulation of heat generation (GO:0031650)2.55772810
126dermatan sulfate biosynthetic process (GO:0030208)2.53923786
127positive regulation of lipoprotein lipase activity (GO:0051006)2.53837992
128positive regulation of triglyceride lipase activity (GO:0061365)2.53837992
129fat-soluble vitamin biosynthetic process (GO:0042362)2.50572114
130dermatan sulfate metabolic process (GO:0030205)2.46073332
131glial cell migration (GO:0008347)2.45956570
132adhesion of symbiont to host (GO:0044406)2.45713049
133positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.44667585
134postsynaptic membrane organization (GO:0001941)2.42199520
135response to manganese ion (GO:0010042)2.35003234
136positive regulation of cholesterol efflux (GO:0010875)2.34838853
137regulation of vitamin metabolic process (GO:0030656)2.34799861
138monocyte chemotaxis (GO:0002548)2.32084175
139positive regulation of extracellular matrix organization (GO:1903055)2.27772936
140negative regulation of leukocyte chemotaxis (GO:0002689)2.26978561
141oligosaccharide catabolic process (GO:0009313)2.26711360
142glycolipid catabolic process (GO:0019377)2.26501399
143regulation of cytokine secretion involved in immune response (GO:0002739)2.22429472
144regulation of T-helper 2 cell differentiation (GO:0045628)2.22085737
145cellular extravasation (GO:0045123)2.21147008
146regulation of chemokine biosynthetic process (GO:0045073)2.20842012
147negative regulation of cell killing (GO:0031342)2.20562185
148negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.20562185
149positive regulation of cholesterol transport (GO:0032376)2.18659112
150positive regulation of sterol transport (GO:0032373)2.18659112
151regulation of vascular endothelial growth factor production (GO:0010574)2.17076668
152regulation of podosome assembly (GO:0071801)2.16641065
153regulation of synapse structural plasticity (GO:0051823)2.16573523
154negative regulation of hemostasis (GO:1900047)2.16177336
155negative regulation of blood coagulation (GO:0030195)2.16177336
156eosinophil chemotaxis (GO:0048245)2.14894532
157gamma-aminobutyric acid transport (GO:0015812)2.14379921
158regulation of monocyte chemotaxis (GO:0090025)2.13143432
159ceramide catabolic process (GO:0046514)2.11176894
160neuron cell-cell adhesion (GO:0007158)2.10196192
161apoptotic cell clearance (GO:0043277)2.09782120
162negative regulation of coagulation (GO:0050819)2.09267249
163macrophage activation (GO:0042116)2.08593571
164macroautophagy (GO:0016236)2.08315029
165membrane lipid catabolic process (GO:0046466)2.06037423
166exogenous drug catabolic process (GO:0042738)2.05714289
167response to magnesium ion (GO:0032026)2.05422555
168drug catabolic process (GO:0042737)2.04963164
169negative regulation of platelet activation (GO:0010544)2.04587881
170chondroitin sulfate biosynthetic process (GO:0030206)2.04395016
171regulation of heterotypic cell-cell adhesion (GO:0034114)2.04081089
172response to nerve growth factor (GO:1990089)2.04004929
173cellular response to nerve growth factor stimulus (GO:1990090)2.04004929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.81850604
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.92265561
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.32033629
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.26902641
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.06606067
6* LXR_22158963_ChIP-Seq_LIVER_Mouse4.00980341
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.90683373
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.39865218
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.35352532
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.92556717
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.80527669
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76424637
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.61609438
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.58858252
15EZH2_22144423_ChIP-Seq_EOC_Human2.46285017
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.44660003
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23820404
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.10688854
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86902143
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86742212
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77526224
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60664884
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59401976
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58741131
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55998982
26GATA1_22025678_ChIP-Seq_K562_Human1.53206662
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50094872
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49970068
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48433946
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48433946
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.44207747
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44117930
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43297634
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43297634
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37730312
36* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37055568
37VDR_24787735_ChIP-Seq_THP-1_Human1.36478067
38TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.35254175
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34893487
40DROSHA_22980978_ChIP-Seq_HELA_Human1.34690566
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32303344
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30501404
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30381918
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30224476
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25925873
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23132279
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22644144
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22477434
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21082283
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20510060
51* FOXA2_19822575_ChIP-Seq_HepG2_Human1.20180704
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20051382
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18111958
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.16712649
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16106191
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15690878
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.15321074
58CLOCK_20551151_ChIP-Seq_293T_Human1.14744335
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12068863
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10092035
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08969352
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08816351
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.08784632
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08327764
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06779560
66REST_21632747_ChIP-Seq_MESCs_Mouse1.06136001
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05392315
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02893070
69* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98917315
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98088065
71* PU_27001747_Chip-Seq_BMDM_Mouse0.97692251
72SMAD_19615063_ChIP-ChIP_OVARY_Human0.97471824
73ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96886134
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96832451
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96743979
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96086804
77* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95983471
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95791679
79LXR_22292898_ChIP-Seq_THP-1_Human0.95758385
80KDM2B_26808549_Chip-Seq_K562_Human0.94761133
81RNF2_27304074_Chip-Seq_ESCs_Mouse0.94381065
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93282954
83GBX2_23144817_ChIP-Seq_PC3_Human0.91523609
84NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91007588
85KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90666192
86PIAS1_25552417_ChIP-Seq_VCAP_Human0.90069389
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89759845
88REST_18959480_ChIP-ChIP_MESCs_Mouse0.89208569
89TP53_16413492_ChIP-PET_HCT116_Human0.88290903
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87038986
91EZH2_27304074_Chip-Seq_ESCs_Mouse0.84965494
92SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84662536
93SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84081598
94* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84077658
95ESR1_21235772_ChIP-Seq_MCF-7_Human0.83597858
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83373988
97CDX2_20551321_ChIP-Seq_CACO-2_Human0.83155892
98SOX2_20726797_ChIP-Seq_SW620_Human0.83079870
99ERG_21242973_ChIP-ChIP_JURKAT_Human0.82702294
100* HNF4A_19822575_ChIP-Seq_HepG2_Human0.82631066
101* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82535250
102GATA1_19941827_ChIP-Seq_MEL_Mouse0.82435287
103HTT_18923047_ChIP-ChIP_STHdh_Human0.82180536
104RUNX_20019798_ChIP-Seq_JUKART_Human0.81603929
105SCL_19346495_ChIP-Seq_HPC-7_Human0.81156772
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81071284
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81017829
108* CJUN_26792858_Chip-Seq_BT549_Human0.80697356
109VDR_24763502_ChIP-Seq_THP-1_Human0.80497036
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80164427
111EP300_21415370_ChIP-Seq_HL-1_Mouse0.80100214
112RXR_22108803_ChIP-Seq_LS180_Human0.79973800
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79751614
114BCAT_22108803_ChIP-Seq_LS180_Human0.79672949
115TP53_18474530_ChIP-ChIP_U2OS_Human0.78528371
116* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78474508
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.78099392
118WT1_19549856_ChIP-ChIP_CCG9911_Human0.77730279
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76402260
120SPI1_23127762_ChIP-Seq_K562_Human0.76348843
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75906522
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75465642
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72425612
124ZFP57_27257070_Chip-Seq_ESCs_Mouse0.70102246
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.68867527
126* GATA2_19941826_ChIP-Seq_K562_Human0.68282546
127EGR1_19032775_ChIP-ChIP_M12_Human0.67631034
128NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.67305099
129RARG_19884340_ChIP-ChIP_MEFs_Mouse0.67071807
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65716726
131* ESR2_21235772_ChIP-Seq_MCF-7_Human0.65141861
132ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.64648619
133AHR_22903824_ChIP-Seq_MCF-7_Human0.64553067
134* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.64291105
135P300_19829295_ChIP-Seq_ESCs_Human0.63383915
136CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63325788
137JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63315983
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.62853341
139SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.61795122
140SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.61139684
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.59437653
142* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.58552014
143AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.58507575
144* PU1_27457419_Chip-Seq_LIVER_Mouse0.58145153

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.73908791
2MP0005360_urolithiasis5.06188422
3MP0005365_abnormal_bile_salt4.31836979
4MP0005085_abnormal_gallbladder_physiolo4.01092714
5MP0008875_abnormal_xenobiotic_pharmacok3.33333424
6MP0009840_abnormal_foam_cell2.96626432
7MP0005083_abnormal_biliary_tract2.73152739
8MP0000569_abnormal_digit_pigmentation2.72719630
9MP0010329_abnormal_lipoprotein_level2.66646146
10MP0003191_abnormal_cellular_cholesterol2.64298004
11MP0003252_abnormal_bile_duct2.64126909
12MP0003436_decreased_susceptibility_to2.61511714
13MP0000604_amyloidosis2.58403308
14MP0003195_calcinosis2.52896037
15MP0005058_abnormal_lysosome_morphology2.51902116
16MP0001835_abnormal_antigen_presentation2.27780005
17MP0003724_increased_susceptibility_to2.05907524
18MP0002419_abnormal_innate_immunity2.01285105
19MP0006082_CNS_inflammation2.00883861
20MP0010368_abnormal_lymphatic_system1.99969010
21MP0003303_peritoneal_inflammation1.98606981
22MP0009764_decreased_sensitivity_to1.95312524
23MP0002138_abnormal_hepatobiliary_system1.88011726
24MP0003806_abnormal_nucleotide_metabolis1.87723034
25MP0003279_aneurysm1.87678927
26MP0003172_abnormal_lysosome_physiology1.86811969
27MP0003690_abnormal_glial_cell1.83738865
28MP0000920_abnormal_myelination1.81182011
29MP0005332_abnormal_amino_acid1.78776415
30MP0002254_reproductive_system_inflammat1.77679047
31MP0001958_emphysema1.76028096
32MP0009785_altered_susceptibility_to1.72655596
33MP0000609_abnormal_liver_physiology1.69802242
34MP0005464_abnormal_platelet_physiology1.60369060
35MP0008469_abnormal_protein_level1.58530999
36MP0005025_abnormal_response_to1.56469826
37MP0008004_abnormal_stomach_pH1.54197211
38MP0003075_altered_response_to1.54195874
39MP0004859_abnormal_synaptic_plasticity1.53421554
40MP0004019_abnormal_vitamin_homeostasis1.51322231
41MP0005319_abnormal_enzyme/_coenzyme1.50519139
42MP0002118_abnormal_lipid_homeostasis1.49496187
43MP0001542_abnormal_bone_strength1.45403234
44MP0001666_abnormal_nutrient_absorption1.45053106
45MP0001533_abnormal_skeleton_physiology1.43289610
46MP0006054_spinal_hemorrhage1.40910764
47MP0002148_abnormal_hypersensitivity_rea1.40475342
48MP0005387_immune_system_phenotype1.38378825
49MP0001790_abnormal_immune_system1.38378825
50MP0004510_myositis1.37307511
51MP0005595_abnormal_vascular_smooth1.37071412
52MP0005000_abnormal_immune_tolerance1.36574873
53MP0003656_abnormal_erythrocyte_physiolo1.32864686
54MP0009763_increased_sensitivity_to1.30663057
55MP0004270_analgesia1.29631869
56MP0003634_abnormal_glial_cell1.22828967
57MP0003705_abnormal_hypodermis_morpholog1.21208790
58MP0005584_abnormal_enzyme/coenzyme_acti1.19753697
59MP0003186_abnormal_redox_activity1.19175311
60MP0000685_abnormal_immune_system1.18384496
61MP0005275_abnormal_skin_tensile1.18220696
62MP0008874_decreased_physiological_sensi1.16566028
63MP0002452_abnormal_antigen_presenting1.15542451
64MP0005166_decreased_susceptibility_to1.14738766
65MP0003828_pulmonary_edema1.14089775
66MP0003091_abnormal_cell_migration1.13088471
67MP0009697_abnormal_copulation1.13049827
68MP0001845_abnormal_inflammatory_respons1.11766086
69MP0003633_abnormal_nervous_system1.10961373
70MP0002723_abnormal_immune_serum1.10770589
71MP0001800_abnormal_humoral_immune1.10712917
72MP0002998_abnormal_bone_remodeling1.10416973
73MP0005167_abnormal_blood-brain_barrier1.09221262
74MP0005408_hypopigmentation1.08912745
75MP0003300_gastrointestinal_ulcer1.07295562
76MP0004947_skin_inflammation1.06293077
77MP0001501_abnormal_sleep_pattern1.05101654
78MP0005023_abnormal_wound_healing1.04845116
79MP0001853_heart_inflammation1.04369593
80MP0005164_abnormal_response_to1.04254493
81MP0002064_seizures1.03503838
82MP0003635_abnormal_synaptic_transmissio1.02608911
83MP0000343_altered_response_to1.02439558
84MP0001764_abnormal_homeostasis0.99971660
85MP0003868_abnormal_feces_composition0.99104597
86MP0003879_abnormal_hair_cell0.98202739
87MP0003453_abnormal_keratinocyte_physiol0.97661426
88MP0003329_amyloid_beta_deposits0.97656918
89MP0002063_abnormal_learning/memory/cond0.95972335
90MP0000598_abnormal_liver_morphology0.94487618
91MP0003011_delayed_dark_adaptation0.92147892
92MP0008438_abnormal_cutaneous_collagen0.90596926
93MP0002876_abnormal_thyroid_physiology0.88463147
94MP0002896_abnormal_bone_mineralization0.86930773
95MP0005423_abnormal_somatic_nervous0.84569571
96MP0009765_abnormal_xenobiotic_induced0.82528681
97MP0004130_abnormal_muscle_cell0.82194630
98MP0003183_abnormal_peptide_metabolism0.81005642
99MP0001545_abnormal_hematopoietic_system0.80895415
100MP0005397_hematopoietic_system_phenotyp0.80895415
101MP0005451_abnormal_body_composition0.80565892
102MP0004883_abnormal_blood_vessel0.79844684
103MP0000249_abnormal_blood_vessel0.79643111
104MP0009643_abnormal_urine_homeostasis0.79243921
105MP0003448_altered_tumor_morphology0.78109472
106MP0005535_abnormal_body_temperature0.77183493
107MP0002090_abnormal_vision0.77033522
108MP0003631_nervous_system_phenotype0.75908018
109MP0009745_abnormal_behavioral_response0.75014902
110MP0009642_abnormal_blood_homeostasis0.74906820
111MP0001970_abnormal_pain_threshold0.73593377
112MP0002933_joint_inflammation0.73560757
113MP0001819_abnormal_immune_cell0.73324436
114MP0002133_abnormal_respiratory_system0.72983369
115MP0005388_respiratory_system_phenotype0.72983369
116MP0002733_abnormal_thermal_nociception0.72766245
117MP0000858_altered_metastatic_potential0.72653675
118MP0010155_abnormal_intestine_physiology0.72559299
119MP0005647_abnormal_sex_gland0.72510536
120MP0005257_abnormal_intraocular_pressure0.72351940
121MP0002420_abnormal_adaptive_immunity0.70182469
122MP0001440_abnormal_grooming_behavior0.70080872
123MP0002734_abnormal_mechanical_nocicepti0.70000349
124MP0003795_abnormal_bone_structure0.69969606
125MP0001879_abnormal_lymphatic_vessel0.69892583
126MP0002928_abnormal_bile_duct0.66383509
127MP0005197_abnormal_uvea_morphology0.65644931
128MP0000371_diluted_coat_color0.65472712
129MP0000767_abnormal_smooth_muscle0.65434562
130MP0001851_eye_inflammation0.64438129
131MP0002006_tumorigenesis0.64292722
132MP0002295_abnormal_pulmonary_circulatio0.62127903
133MP0009278_abnormal_bone_marrow0.61414669
134MP0005376_homeostasis/metabolism_phenot0.61061759
135MP0005390_skeleton_phenotype0.60523054
136MP0004858_abnormal_nervous_system0.60418080
137MP0002332_abnormal_exercise_endurance0.60120739
138MP0002166_altered_tumor_susceptibility0.59585089
139MP0008260_abnormal_autophagy0.59355938

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)5.72590650
2Complement deficiency (HP:0004431)5.46955819
3Deep venous thrombosis (HP:0002625)5.28878228
4Abnormality of glycolipid metabolism (HP:0010969)5.22928789
5Abnormality of liposaccharide metabolism (HP:0010968)5.22928789
6Abnormality of glycosphingolipid metabolism (HP:0004343)5.22928789
7Systemic lupus erythematosus (HP:0002725)5.14471381
8Recurrent bacterial skin infections (HP:0005406)5.05417150
9Prolonged partial thromboplastin time (HP:0003645)4.95514142
10Intrahepatic cholestasis (HP:0001406)4.90000379
11Xanthomatosis (HP:0000991)4.86699376
12Joint hemorrhage (HP:0005261)4.83664926
13Recurrent abscess formation (HP:0002722)4.74807357
14Mutism (HP:0002300)4.61771721
15Abnormality of aromatic amino acid family metabolism (HP:0004338)4.36643956
16Abnormality of complement system (HP:0005339)4.36595026
17Abnormality of monocarboxylic acid metabolism (HP:0010996)4.33978654
18Myocardial infarction (HP:0001658)4.23589742
19Glomerulonephritis (HP:0000099)4.14437001
20Eczematoid dermatitis (HP:0000976)3.97727003
21Hyperlipoproteinemia (HP:0010980)3.96492973
22Epidermoid cyst (HP:0200040)3.73869214
23Hypercholesterolemia (HP:0003124)3.60718411
24Abnormality of the common coagulation pathway (HP:0010990)3.58380370
25Hypobetalipoproteinemia (HP:0003563)3.54308203
26Prostate neoplasm (HP:0100787)3.45637304
27Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.42287461
28Hypoalphalipoproteinemia (HP:0003233)3.25153517
29Vacuolated lymphocytes (HP:0001922)3.21458428
30Loss of speech (HP:0002371)3.15323320
31Amyloidosis (HP:0011034)3.13502978
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.12584245
33Hypolipoproteinemia (HP:0010981)3.12174009
34Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.11141110
35Abnormality of macrophages (HP:0004311)3.08633797
36Fat malabsorption (HP:0002630)3.05412878
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.02666102
38Recurrent skin infections (HP:0001581)3.02102691
39Axonal loss (HP:0003447)3.00781001
40Supranuclear gaze palsy (HP:0000605)2.86834504
41Abnormality of the frontal sinuses (HP:0002687)2.85436990
42Apathy (HP:0000741)2.84712778
43Skin nodule (HP:0200036)2.80996537
44Disinhibition (HP:0000734)2.79767019
45Nephritis (HP:0000123)2.78810061
46Gingival bleeding (HP:0000225)2.78033833
47Diminished motivation (HP:0000745)2.76312994
48Gingivitis (HP:0000230)2.74313473
49Esophageal varix (HP:0002040)2.73351959
50Abnormality of sulfur amino acid metabolism (HP:0004339)2.72148018
51Neuronal loss in central nervous system (HP:0002529)2.62279126
52Increased cerebral lipofuscin (HP:0011813)2.61496677
53Neurofibrillary tangles (HP:0002185)2.60082046
54Conjugated hyperbilirubinemia (HP:0002908)2.59835762
55Steatorrhea (HP:0002570)2.59618519
56Spontaneous abortion (HP:0005268)2.59372451
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.59025567
58Mitral stenosis (HP:0001718)2.50241056
59Abnormality of pyrimidine metabolism (HP:0004353)2.48384886
60Abnormality of methionine metabolism (HP:0010901)2.48042914
61Hyperammonemia (HP:0001987)2.46309809
62Ketosis (HP:0001946)2.44826738
63Spontaneous hematomas (HP:0007420)2.44432413
64Abnormality of the intrinsic pathway (HP:0010989)2.43744652
65Mediastinal lymphadenopathy (HP:0100721)2.43515512
66Upper motor neuron abnormality (HP:0002127)2.41254850
67Retinal atrophy (HP:0001105)2.40564905
68Vertebral compression fractures (HP:0002953)2.40052828
69Autoimmune thrombocytopenia (HP:0001973)2.33874813
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.32945089
71Myositis (HP:0100614)2.27458914
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.27230717
73Hematochezia (HP:0002573)2.27080003
74Urticaria (HP:0001025)2.26095526
75Purpura (HP:0000979)2.25395548
76Tetraparesis (HP:0002273)2.21888660
77Optic neuritis (HP:0100653)2.21656782
78Retrobulbar optic neuritis (HP:0100654)2.21656782
79Menorrhagia (HP:0000132)2.21157989
80Dysostosis multiplex (HP:0000943)2.19454237
81Periodontitis (HP:0000704)2.15360886
82Hyperglycinemia (HP:0002154)2.15135455
83Polyphagia (HP:0002591)2.13896700
84Thick nail (HP:0001805)2.12739014
85Protrusio acetabuli (HP:0003179)2.11028281
86Increased serum ferritin (HP:0003281)2.10538230
87Absent frontal sinuses (HP:0002688)2.09882287
88Mucopolysacchariduria (HP:0008155)2.08231626
89Urinary glycosaminoglycan excretion (HP:0003541)2.08231626
90Abnormality of polysaccharide metabolism (HP:0011012)2.07533795
91Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07533795
92Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07533795
93Pathologic fracture (HP:0002756)2.07042424
94Thrombophlebitis (HP:0004418)2.06683238
95Inappropriate behavior (HP:0000719)2.04272818
96Abnormality of nucleobase metabolism (HP:0010932)2.04267664
97Malnutrition (HP:0004395)2.03993612
98Lower limb hyperreflexia (HP:0002395)2.03784879
99Sensorimotor neuropathy (HP:0007141)2.02841657
100Cerebral inclusion bodies (HP:0100314)2.02534081
101Abnormality of proline metabolism (HP:0010907)2.02517608
102Hydroxyprolinuria (HP:0003080)2.02517608
103Hyperglycinuria (HP:0003108)1.96909430
104Peritonitis (HP:0002586)1.96323967
105Abnormality of the prostate (HP:0008775)1.96257482
106Asymmetric septal hypertrophy (HP:0001670)1.94954079
107Dementia (HP:0000726)1.94712878
108Polycythemia (HP:0001901)1.92319719
109Stomatitis (HP:0010280)1.91974534
110Abnormality of iron homeostasis (HP:0011031)1.91805084
111Hepatocellular carcinoma (HP:0001402)1.91611939
112Peripheral demyelination (HP:0011096)1.90746326
113Agnosia (HP:0010524)1.89657437
114Hypoglycemic coma (HP:0001325)1.89002578
115Peripheral hypomyelination (HP:0007182)1.87984947
116Abnormality of the vasculature of the conjunctiva (HP:0008054)1.87813642
117Hypochromic microcytic anemia (HP:0004840)1.87726808
118Orchitis (HP:0100796)1.87631731
119Nuclear cataract (HP:0100018)1.86861362
120Metaphyseal dysplasia (HP:0100255)1.86761651
121Pulmonary embolism (HP:0002204)1.86513759
122Multiple lipomas (HP:0001012)1.86162734
123Conjunctival telangiectasia (HP:0000524)1.85082375
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82816315
125Abnormality of glycine metabolism (HP:0010895)1.82276057
126Abnormality of serine family amino acid metabolism (HP:0010894)1.82276057
127Abnormality of purine metabolism (HP:0004352)1.82209054
128Hemorrhage of the eye (HP:0011885)1.81473938
129Abnormal eating behavior (HP:0100738)1.76561074
130Prolonged neonatal jaundice (HP:0006579)1.75119865
131Cervical subluxation (HP:0003308)1.72959011
132Spondylolisthesis (HP:0003302)1.71689110
133Hyperventilation (HP:0002883)1.71628966
134Rapidly progressive (HP:0003678)1.70879376
135Action tremor (HP:0002345)1.69800326
136Thin bony cortex (HP:0002753)1.69717665
137Abnormality of the periventricular white matter (HP:0002518)1.69472007
138Memory impairment (HP:0002354)1.67339268
139Interstitial pulmonary disease (HP:0006530)1.66130819
140Torticollis (HP:0000473)1.64869134
141Cerebral aneurysm (HP:0004944)1.64691927
142Hemoptysis (HP:0002105)1.64477332
143Premature rupture of membranes (HP:0001788)1.64342540
144Joint stiffness (HP:0001387)1.63487256
145Bone pain (HP:0002653)1.62742021
146Broad metatarsal (HP:0001783)1.61902809
147Ankle clonus (HP:0011448)1.60340902
148Aortic aneurysm (HP:0004942)1.60019202
149Metaphyseal irregularity (HP:0003025)1.58553062
150Absent speech (HP:0001344)1.58111615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.49977878
2TAOK33.34986470
3MAP3K143.32866038
4DDR23.32075885
5IRAK33.03825217
6TYK22.93478427
7ERN12.80330403
8TBK12.78603684
9MARK12.67892861
10KIT2.23252408
11SIK12.20044741
12CAMK1D2.19559476
13IRAK42.13633916
14IKBKE2.03008862
15ERBB41.96250729
16JAK31.94410205
17MAP3K131.93266025
18JAK11.93259774
19FGR1.82178198
20PRPF4B1.82165811
21CAMK1G1.78177619
22BLK1.78134553
23FGFR41.72060523
24SIK21.71129698
25PBK1.65053231
26CASK1.64258196
27INSRR1.62728780
28DAPK21.50921761
29TAOK11.50492791
30CDC42BPA1.48332940
31NEK91.47162258
32BCKDK1.46480514
33IKBKB1.46340759
34ARAF1.40012995
35TYRO31.38827987
36CSK1.38613797
37TAOK21.38025269
38JAK21.36823523
39ABL21.33942438
40TESK11.33832566
41TGFBR21.31274065
42MAP2K71.28962925
43CSF1R1.23925899
44PAK61.21206318
45NTRK21.16909640
46PDGFRB1.14476481
47MAP3K111.14134851
48MAP3K41.11898739
49FES1.11169026
50LIMK11.10959127
51MAP3K21.10378438
52MAP3K31.08623917
53BMPR21.05130274
54RIPK11.03413974
55PIM21.02917753
56NTRK31.02659537
57HCK1.01098998
58CHUK0.98794670
59MAP2K40.94683531
60PIK3CG0.93174544
61ADRBK20.92754683
62GRK70.92698971
63KSR20.90419481
64LATS20.88800472
65EGFR0.88458505
66MAP3K60.88068199
67KSR10.87264970
68CAMKK20.86767087
69MST1R0.84612365
70CAMK2G0.82553369
71LYN0.82405121
72PRKD20.79875936
73MARK20.77277469
74MAPK130.76667523
75CAMKK10.75847101
76MAPK70.75401633
77CAMK2B0.73555711
78MAP3K90.72951806
79NTRK10.71982074
80SYK0.71767914
81MAP3K10.71652261
82MAPK110.70433102
83ERBB20.69941404
84PRKCZ0.68576730
85ABL10.68439329
86IGF1R0.66400865
87SGK2230.66095976
88SGK4940.66095976
89LCK0.65889817
90MARK30.64528512
91CDK50.64266174
92CDK60.63740159
93PRKCD0.63470169
94PKN10.62458964
95PTK60.61534822
96STK380.61161923
97MAPK40.60684328
98MATK0.60073338
99PDPK10.59843178
100GRK50.59459492
101PRKAA20.58516009
102BMX0.58248249
103RAF10.56583530
104CSNK1G20.55972618
105MAP3K50.53587424
106ERBB30.52230714
107TXK0.52066006
108LATS10.51021336
109ZAP700.50811794
110CAMK2A0.50589130
111CAMK40.50561431
112FGFR30.50081082
113MAPK120.50014648
114EIF2AK20.49813179
115YES10.49542432
116TNK20.48679861
117FYN0.48407252
118IRAK20.47907975
119PRKCG0.47368847
120FRK0.45474113
121SGK30.45195924
122PDGFRA0.44700781
123ACVR1B0.44628332
124DMPK0.42813546
125EPHB20.42297724
126PRKACG0.41852227
127NME20.41817813
128MYLK0.41751810
129EPHA40.41445728
130GSK3A0.40673905
131MAP2K30.40616202
132RPS6KA40.39846377
133SGK10.39407966
134DYRK1B0.39238750
135EPHB10.38928213
136PDK10.38428782
137EPHA30.37682741
138SIK30.37668536
139PRKCQ0.37379014
140MAP4K10.37007779
141TTN0.36684061
142MOS0.36567647
143RPS6KA20.36550921
144PLK20.36417410
145TEC0.36128056
146SGK20.35863561

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.39254640
2Staphylococcus aureus infection_Homo sapiens_hsa051503.96262128
3Complement and coagulation cascades_Homo sapiens_hsa046103.43229165
4Nitrogen metabolism_Homo sapiens_hsa009103.26678423
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.83823608
6Arginine biosynthesis_Homo sapiens_hsa002202.64276648
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.48186810
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25930110
9Tryptophan metabolism_Homo sapiens_hsa003802.10687551
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.92787255
11Caffeine metabolism_Homo sapiens_hsa002321.81144566
12Fatty acid degradation_Homo sapiens_hsa000711.80373084
13Peroxisome_Homo sapiens_hsa041461.76201363
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73037875
15PPAR signaling pathway_Homo sapiens_hsa033201.72485458
16Histidine metabolism_Homo sapiens_hsa003401.66571830
17Chemical carcinogenesis_Homo sapiens_hsa052041.58969557
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.58118161
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53629512
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52549825
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52125533
22Mineral absorption_Homo sapiens_hsa049781.48339071
23Bile secretion_Homo sapiens_hsa049761.42753654
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42252375
25Leishmaniasis_Homo sapiens_hsa051401.40232824
26Steroid biosynthesis_Homo sapiens_hsa001001.38434461
27beta-Alanine metabolism_Homo sapiens_hsa004101.37202521
28Butanoate metabolism_Homo sapiens_hsa006501.33516965
29Retinol metabolism_Homo sapiens_hsa008301.32502067
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.26239352
31Fatty acid metabolism_Homo sapiens_hsa012121.26049491
32Phenylalanine metabolism_Homo sapiens_hsa003601.24295152
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24010239
34Synaptic vesicle cycle_Homo sapiens_hsa047211.22030047
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20242945
36ABC transporters_Homo sapiens_hsa020101.16825283
37Pertussis_Homo sapiens_hsa051331.15722224
38Starch and sucrose metabolism_Homo sapiens_hsa005001.10032945
39Collecting duct acid secretion_Homo sapiens_hsa049661.07573852
40Lysosome_Homo sapiens_hsa041421.06516553
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03590074
42Malaria_Homo sapiens_hsa051441.00516659
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00477414
44Prion diseases_Homo sapiens_hsa050200.99738377
45Osteoclast differentiation_Homo sapiens_hsa043800.99202214
46Tyrosine metabolism_Homo sapiens_hsa003500.98910065
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.97718184
48Tuberculosis_Homo sapiens_hsa051520.95225197
49Phagosome_Homo sapiens_hsa041450.94468447
50Propanoate metabolism_Homo sapiens_hsa006400.93556977
51Vitamin digestion and absorption_Homo sapiens_hsa049770.88909131
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88467808
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86152978
54Selenocompound metabolism_Homo sapiens_hsa004500.85150919
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85128489
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84237512
57Graft-versus-host disease_Homo sapiens_hsa053320.82795693
58Vibrio cholerae infection_Homo sapiens_hsa051100.82692250
59Legionellosis_Homo sapiens_hsa051340.78611033
60Shigellosis_Homo sapiens_hsa051310.78366087
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.76412448
62GABAergic synapse_Homo sapiens_hsa047270.73285101
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72358895
64African trypanosomiasis_Homo sapiens_hsa051430.71986549
65TNF signaling pathway_Homo sapiens_hsa046680.71411143
66Rheumatoid arthritis_Homo sapiens_hsa053230.71307712
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66606245
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66315013
69Fat digestion and absorption_Homo sapiens_hsa049750.66180664
70Cocaine addiction_Homo sapiens_hsa050300.64949637
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64769448
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63599802
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.63508635
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62854536
75Bladder cancer_Homo sapiens_hsa052190.62797124
76Influenza A_Homo sapiens_hsa051640.60442540
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.59306595
78Sulfur metabolism_Homo sapiens_hsa009200.58167892
79Sphingolipid metabolism_Homo sapiens_hsa006000.58009626
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.57316404
81Dorso-ventral axis formation_Homo sapiens_hsa043200.57000982
82Lysine degradation_Homo sapiens_hsa003100.56107527
83Prolactin signaling pathway_Homo sapiens_hsa049170.55961837
84Fatty acid elongation_Homo sapiens_hsa000620.54950641
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.54835003
86GnRH signaling pathway_Homo sapiens_hsa049120.53780680
87Nicotine addiction_Homo sapiens_hsa050330.53112465
88Fatty acid biosynthesis_Homo sapiens_hsa000610.51840515
89Glutamatergic synapse_Homo sapiens_hsa047240.51205414
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51006444
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50828696
92Other glycan degradation_Homo sapiens_hsa005110.50124145
93Hepatitis C_Homo sapiens_hsa051600.49937700
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49719974
95Endocytosis_Homo sapiens_hsa041440.49400850
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49366670
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48461220
98Folate biosynthesis_Homo sapiens_hsa007900.47873193
99Gap junction_Homo sapiens_hsa045400.47306254
100Morphine addiction_Homo sapiens_hsa050320.47253507
101Salmonella infection_Homo sapiens_hsa051320.46674440
102VEGF signaling pathway_Homo sapiens_hsa043700.46124351
103Insulin resistance_Homo sapiens_hsa049310.45613876
104Measles_Homo sapiens_hsa051620.45230098
105Arginine and proline metabolism_Homo sapiens_hsa003300.44673489
106Hematopoietic cell lineage_Homo sapiens_hsa046400.44657023
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43902859
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43174315
109Amoebiasis_Homo sapiens_hsa051460.43171797
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.43126528
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42185153
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40932549
113Long-term depression_Homo sapiens_hsa047300.40776778
114Renal cell carcinoma_Homo sapiens_hsa052110.40408940
115Estrogen signaling pathway_Homo sapiens_hsa049150.40248753
116Type II diabetes mellitus_Homo sapiens_hsa049300.39522730
117Renin secretion_Homo sapiens_hsa049240.38784739
118Arachidonic acid metabolism_Homo sapiens_hsa005900.38756174
119Sulfur relay system_Homo sapiens_hsa041220.38152507
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38024640
121Chemokine signaling pathway_Homo sapiens_hsa040620.37842948
122Toxoplasmosis_Homo sapiens_hsa051450.37469977
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36978126
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.36608235
125B cell receptor signaling pathway_Homo sapiens_hsa046620.33271130
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.32598437
127Glycerolipid metabolism_Homo sapiens_hsa005610.31658236
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31653393
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29953240
130Asthma_Homo sapiens_hsa053100.28689297
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28421071
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26565612
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25699316
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22293038
135Pyruvate metabolism_Homo sapiens_hsa006200.22112572
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20770996
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20449398
138Carbon metabolism_Homo sapiens_hsa012000.19274504
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19027516

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