PICK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.97365504
2polyketide metabolic process (GO:0030638)5.66862918
3doxorubicin metabolic process (GO:0044598)5.66862918
4daunorubicin metabolic process (GO:0044597)5.66862918
5glutamate secretion (GO:0014047)4.57912645
6positive regulation of synapse maturation (GO:0090129)4.53211264
7synaptic vesicle exocytosis (GO:0016079)4.44442913
8regulation of ARF GTPase activity (GO:0032312)4.24880503
9sperm capacitation (GO:0048240)4.15291918
10cell-cell junction maintenance (GO:0045217)4.14575590
11cytoskeletal anchoring at plasma membrane (GO:0007016)4.00435819
12negative regulation of cell size (GO:0045792)3.92241060
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.81178749
14regulation of synapse maturation (GO:0090128)3.76377059
15sperm motility (GO:0030317)3.69510057
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.67865769
17sodium ion export (GO:0071436)3.65176776
18acrosome reaction (GO:0007340)3.61617300
19regulation of ARF protein signal transduction (GO:0032012)3.59469559
20dendritic spine morphogenesis (GO:0060997)3.57086585
21aminoglycoside antibiotic metabolic process (GO:0030647)3.53913505
22locomotory exploration behavior (GO:0035641)3.52087426
23vocalization behavior (GO:0071625)3.51157689
24cell junction maintenance (GO:0034331)3.40157657
25establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.33089344
26mitochondrion transport along microtubule (GO:0047497)3.33089344
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.30087812
28sulfate transmembrane transport (GO:1902358)3.28841207
29fusion of sperm to egg plasma membrane (GO:0007342)3.28076928
30regulation of short-term neuronal synaptic plasticity (GO:0048172)3.26651973
31regulation of synaptic vesicle transport (GO:1902803)3.25567620
32negative regulation of inclusion body assembly (GO:0090084)3.25063726
33glycine transport (GO:0015816)3.24956335
34G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.23947156
35regulation of somitogenesis (GO:0014807)3.19868602
36synaptic transmission, glutamatergic (GO:0035249)3.19492044
37neuron cell-cell adhesion (GO:0007158)3.16595712
38regulation of glutamate receptor signaling pathway (GO:1900449)3.14404275
39central nervous system projection neuron axonogenesis (GO:0021952)3.12805047
40postsynaptic membrane organization (GO:0001941)3.07766678
41neurotransmitter secretion (GO:0007269)3.06928554
42presynaptic membrane assembly (GO:0097105)3.06708092
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06439754
44transmission of nerve impulse (GO:0019226)3.06231178
45intracellular estrogen receptor signaling pathway (GO:0030520)3.06160524
46calcium ion-dependent exocytosis (GO:0017156)3.03362565
47phosphatidylethanolamine biosynthetic process (GO:0006646)3.02199872
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02144865
49positive regulation of action potential (GO:0045760)3.00706726
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98342880
51head development (GO:0060322)2.97461311
52layer formation in cerebral cortex (GO:0021819)2.96056624
53peptidyl-tyrosine autophosphorylation (GO:0038083)2.95534580
54auditory receptor cell stereocilium organization (GO:0060088)2.94950578
55microtubule severing (GO:0051013)2.93611805
56cell migration in hindbrain (GO:0021535)2.92962818
57glutamate receptor signaling pathway (GO:0007215)2.92359273
58cranial nerve morphogenesis (GO:0021602)2.92287544
59neuron remodeling (GO:0016322)2.90954030
60protein retention in ER lumen (GO:0006621)2.90200720
61positive regulation of Rab GTPase activity (GO:0032851)2.88888271
62regulation of Rab GTPase activity (GO:0032313)2.88888271
63presynaptic membrane organization (GO:0097090)2.86899694
64negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86845066
65exploration behavior (GO:0035640)2.85700370
66cerebral cortex radially oriented cell migration (GO:0021799)2.85524090
67sexual reproduction (GO:0019953)2.83612802
68response to acidic pH (GO:0010447)2.81009883
69histone H3-K4 trimethylation (GO:0080182)2.80407229
70adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.80062837
71dopamine receptor signaling pathway (GO:0007212)2.78664827
72neuromuscular process controlling balance (GO:0050885)2.78049315
73negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.77792026
74regulation of neuronal synaptic plasticity (GO:0048168)2.76393160
75lateral sprouting from an epithelium (GO:0060601)2.75490218
76positive regulation of synaptic transmission, GABAergic (GO:0032230)2.75224318
77neuronal action potential propagation (GO:0019227)2.74448976
78synaptic vesicle docking involved in exocytosis (GO:0016081)2.73780300
79neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.73420161
80axon ensheathment in central nervous system (GO:0032291)2.73103995
81central nervous system myelination (GO:0022010)2.73103995
82respiratory system process (GO:0003016)2.72669357
83regulation of inclusion body assembly (GO:0090083)2.71357958
84negative regulation of erythrocyte differentiation (GO:0045647)2.68490309
85activation of protein kinase A activity (GO:0034199)2.68317462
86regulation of female receptivity (GO:0045924)2.68297971
87semaphorin-plexin signaling pathway (GO:0071526)2.67582032
88sulfate transport (GO:0008272)2.65863221
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65289452
90neuron-neuron synaptic transmission (GO:0007270)2.64850966
91phosphatidylethanolamine metabolic process (GO:0046337)2.64719034
92* dendritic spine organization (GO:0097061)2.62475891
93mannose metabolic process (GO:0006013)2.61942800
94opioid receptor signaling pathway (GO:0038003)2.61798278
95calcium ion import (GO:0070509)2.61243827
96detection of calcium ion (GO:0005513)2.61078109
97regulation of pigment cell differentiation (GO:0050932)2.59788288
98receptor recycling (GO:0001881)2.59515117
99actin filament capping (GO:0051693)2.58409225
100cellular anion homeostasis (GO:0030002)2.57935379
101* cellular component maintenance (GO:0043954)2.56300823
102histone H3 deacetylation (GO:0070932)2.55804591
103exocrine pancreas development (GO:0031017)2.55709080
104G-protein coupled receptor internalization (GO:0002031)2.54880497
105membrane hyperpolarization (GO:0060081)2.54796146
106regulation of synaptic vesicle exocytosis (GO:2000300)2.54730690
107protein localization to synapse (GO:0035418)2.54614943
108positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.53803147
109central nervous system neuron axonogenesis (GO:0021955)2.52740486
110positive regulation of icosanoid secretion (GO:0032305)2.52735212
111righting reflex (GO:0060013)2.52433734
112inner ear receptor stereocilium organization (GO:0060122)2.51491259
113female mating behavior (GO:0060180)2.51210957
114regulation of excitatory postsynaptic membrane potential (GO:0060079)2.51207786
115positive regulation of membrane potential (GO:0045838)2.51168695
116histone H4 deacetylation (GO:0070933)2.50044682
117apical protein localization (GO:0045176)2.49772433
118establishment of apical/basal cell polarity (GO:0035089)2.48872132
119synaptic vesicle endocytosis (GO:0048488)2.48743721
120myelin maintenance (GO:0043217)2.48680368
121regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.48430323
122protein kinase C signaling (GO:0070528)2.47796713
123negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.47669587
124negative regulation of microtubule polymerization (GO:0031115)2.47315704
125protein localization to endosome (GO:0036010)2.47134381
126positive regulation of neurological system process (GO:0031646)2.47042883
127regulation of T-helper 2 cell differentiation (GO:0045628)2.46249891
128membrane depolarization during action potential (GO:0086010)2.46054101
129regulation of postsynaptic membrane potential (GO:0060078)2.45814700
130cell volume homeostasis (GO:0006884)2.45724606
131multicellular organismal signaling (GO:0035637)2.45633424
132urinary tract smooth muscle contraction (GO:0014848)2.44980881
133* neuronal ion channel clustering (GO:0045161)2.44227244
134cerebellar granule cell differentiation (GO:0021707)2.43471263
135negative regulation of heart rate (GO:0010459)2.43413686
136auditory behavior (GO:0031223)2.42007013
137positive regulation of neurotransmitter secretion (GO:0001956)2.41433185
138plasma membrane fusion (GO:0045026)2.40353119
139* regulation of synaptic plasticity (GO:0048167)2.40323208
140face development (GO:0060324)2.40036491
141maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.39575461
142nucleosome disassembly (GO:0006337)2.39227955
143protein-DNA complex disassembly (GO:0032986)2.39227955
144positive regulation of CREB transcription factor activity (GO:0032793)2.38379859
145neuromuscular process controlling posture (GO:0050884)2.38348745
146regulation of neurotransmitter levels (GO:0001505)2.38273171
147negative regulation of neurotransmitter transport (GO:0051589)2.37975222
148startle response (GO:0001964)2.37227234
149amino acid import (GO:0043090)2.37128085
150mesenchymal cell differentiation (GO:0048762)2.35797438
151regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.35565664
152establishment of planar polarity (GO:0001736)2.34177206
153establishment of tissue polarity (GO:0007164)2.34177206
154gamma-aminobutyric acid signaling pathway (GO:0007214)2.33672621
155activation of Rac GTPase activity (GO:0032863)2.33158690
156dicarboxylic acid transport (GO:0006835)2.32854290
157response to auditory stimulus (GO:0010996)2.32590079
158positive regulation of prostaglandin secretion (GO:0032308)2.32029463
159dendrite morphogenesis (GO:0048813)2.31880127
160cellular response to pH (GO:0071467)2.31873934
161neurotransmitter-gated ion channel clustering (GO:0072578)2.31710588
162reflex (GO:0060004)2.31560286
163mitochondrion localization (GO:0051646)2.30412739
164synaptic vesicle maturation (GO:0016188)2.29824745
165ear development (GO:0043583)2.29804708
166bicarbonate transport (GO:0015701)2.29670936
167post-embryonic morphogenesis (GO:0009886)2.29339137
168L-amino acid import (GO:0043092)2.29256117
169establishment of mitochondrion localization (GO:0051654)2.28773738
170cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.28753764
171regulation of long-term neuronal synaptic plasticity (GO:0048169)2.28717052
172insulin-like growth factor receptor signaling pathway (GO:0048009)2.28491052
173regulation of transcription involved in cell fate commitment (GO:0060850)2.28411020
174phosphorelay signal transduction system (GO:0000160)2.28335504
175membrane tubulation (GO:0097320)2.28306864
176membrane depolarization (GO:0051899)2.27879457
177neurotransmitter transport (GO:0006836)2.27413757
178cerebral cortex neuron differentiation (GO:0021895)2.27083724
179regulation of cholesterol biosynthetic process (GO:0045540)2.26929284
180cellular potassium ion homeostasis (GO:0030007)2.26914750
181creatine metabolic process (GO:0006600)2.26814917
182retina layer formation (GO:0010842)2.26755118
183drinking behavior (GO:0042756)2.26697854
184cerebellar Purkinje cell differentiation (GO:0021702)2.26295937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.40000904
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.03798815
3GBX2_23144817_ChIP-Seq_PC3_Human3.63365108
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.46309142
5* LXR_22292898_ChIP-Seq_THP-1_Human3.18520555
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.74772622
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62858918
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.41407234
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.36467821
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35461177
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.34990313
12P68_20966046_ChIP-Seq_HELA_Human2.33740429
13DROSHA_22980978_ChIP-Seq_HELA_Human2.29473596
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.28024544
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.24459512
16SMC4_20622854_ChIP-Seq_HELA_Human2.23880834
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23791826
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22530241
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.20816685
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20323960
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20323960
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15603800
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15387273
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12783720
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.12334779
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03250253
27REST_21632747_ChIP-Seq_MESCs_Mouse2.03250129
28KDM2B_26808549_Chip-Seq_K562_Human2.02886818
29ELF1_20517297_ChIP-Seq_JURKAT_Human2.02881061
30EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.01771333
31VDR_21846776_ChIP-Seq_THP-1_Human2.00561467
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.97614850
33RACK7_27058665_Chip-Seq_MCF-7_Human1.96969531
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96050815
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.95974423
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.94955619
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94525962
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.92602347
39* KDM2B_26808549_Chip-Seq_DND41_Human1.91109901
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87476633
41SA1_27219007_Chip-Seq_ERYTHROID_Human1.85347018
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85203680
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.83945124
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83137755
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82124210
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.78407980
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77072587
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77071646
49* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75393149
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.75359551
51BCOR_27268052_Chip-Seq_Bcells_Human1.74022785
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73803487
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72196001
54TCF7_22412390_ChIP-Seq_EML_Mouse1.71408682
55BCL6_27268052_Chip-Seq_Bcells_Human1.70559604
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.67886785
57CREB1_26743006_Chip-Seq_LNCaP_Human1.67619986
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.66810995
59CTCF_27219007_Chip-Seq_ERYTHROID_Human1.64002139
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58777565
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58620093
62TET1_21490601_ChIP-Seq_MESCs_Mouse1.53527630
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.53143100
64TP63_22573176_ChIP-Seq_HFKS_Human1.52439036
65* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52221360
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51742181
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.49814067
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49111586
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.49025398
70PHF8_20622854_ChIP-Seq_HELA_Human1.47197955
71MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.46494429
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.44847558
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42841196
74SA1_27219007_Chip-Seq_Bcells_Human1.42268327
75E2F1_20622854_ChIP-Seq_HELA_Human1.40772049
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40128708
77RNF2_27304074_Chip-Seq_NSC_Mouse1.39295701
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38983839
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38613914
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36847545
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36425849
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36425849
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35612253
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.35387667
85AR_21572438_ChIP-Seq_LNCaP_Human1.35374932
86OCT4_19829295_ChIP-Seq_ESCs_Human1.33714014
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.32294385
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32208046
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.31669240
90RARB_27405468_Chip-Seq_BRAIN_Mouse1.30933289
91CTCF_20526341_ChIP-Seq_ESCs_Human1.30543828
92MYC_22102868_ChIP-Seq_BL_Human1.29873529
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29743461
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28088285
95TAF15_26573619_Chip-Seq_HEK293_Human1.27463427
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27192005
97REST_18959480_ChIP-ChIP_MESCs_Mouse1.26877059
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26610434
99SMAD4_21799915_ChIP-Seq_A2780_Human1.26517822
100STAT3_23295773_ChIP-Seq_U87_Human1.26420153
101* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24256568
102YY1_22570637_ChIP-Seq_MALME-3M_Human1.23972969
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23879099
104CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23030996
105P300_19829295_ChIP-Seq_ESCs_Human1.22934418
106TP53_22127205_ChIP-Seq_IMR90_Human1.22905182
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22300571
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22245102
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21733169
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.21100015
111BP1_19119308_ChIP-ChIP_Hs578T_Human1.20511733
112FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20202909
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.20089321
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19893854
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19873378
116TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.19270959
117PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18621214
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18173521
119P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17816834
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17797093
121RING1B_27294783_Chip-Seq_NPCs_Mouse1.16542026
122JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.15908010
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15335840
124ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15295706
125YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14494445
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.13942453
127TCF4_23295773_ChIP-Seq_U87_Human1.12537537
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.12450160
129KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11431282
130KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11431282
131KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11431282
132NFE2_27457419_Chip-Seq_LIVER_Mouse1.11068392
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09801198
134ZNF263_19887448_ChIP-Seq_K562_Human1.08766301
135AHR_22903824_ChIP-Seq_MCF-7_Human1.08005460
136ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07913987
137* RARA_24833708_ChIP-Seq_LIVER_Mouse1.07512104
138E2F1_18555785_Chip-Seq_ESCs_Mouse1.07288179
139EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07031595
140KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06054650
141FOXP1_21924763_ChIP-Seq_HESCs_Human1.06041099
142GATA1_19941827_ChIP-Seq_MEL_Mouse1.05736361
143* AR_19668381_ChIP-Seq_PC3_Human1.05586859
144* RARB_24833708_ChIP-Seq_LIVER_Mouse1.05572222
145VDR_22108803_ChIP-Seq_LS180_Human1.05017425
146WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04894102
147POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04886201
148PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04383073
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04131677
150MAF_26560356_Chip-Seq_TH2_Human1.03604858
151ETS1_21867929_ChIP-Seq_TH2_Mouse1.03400413
152CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02442039
153ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01889736
154* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01395159
155* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01246613
156CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01183655
157TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00939219
158P53_22387025_ChIP-Seq_ESCs_Mouse1.00911380
159P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00895086
160AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00834112
161SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99985590
162MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99751788
163SOX2_21211035_ChIP-Seq_LN229_Gbm0.99282125
164* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99243072
165EZH2_27294783_Chip-Seq_NPCs_Mouse0.98467596
166CTCF_27219007_Chip-Seq_Bcells_Human0.98210059
167CMYC_18555785_Chip-Seq_ESCs_Mouse0.97919448
168AR_25329375_ChIP-Seq_VCAP_Human0.97899003
169WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97872700
170RUNX2_22187159_ChIP-Seq_PCA_Human0.97522631
171RAC3_21632823_ChIP-Seq_H3396_Human0.96818729
172ERA_21632823_ChIP-Seq_H3396_Human0.96561138
173RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96285093
174CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95837206
175SMAD4_21741376_ChIP-Seq_HESCs_Human0.95304310
176CTCF_21964334_Chip-Seq_Bcells_Human0.95076976
177TP53_18474530_ChIP-ChIP_U2OS_Human0.94704811
178TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94570088
179TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94499747
180SMAD3_21741376_ChIP-Seq_HESCs_Human0.94166676
181OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93824094
182IGF1R_20145208_ChIP-Seq_DFB_Human0.93747411
183P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92866438
184PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92718789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.95854301
2MP0000566_synostosis3.59847439
3MP0005410_abnormal_fertilization3.18982827
4MP0005645_abnormal_hypothalamus_physiol2.87729148
5MP0003878_abnormal_ear_physiology2.79571444
6MP0005377_hearing/vestibular/ear_phenot2.79571444
7MP0003329_amyloid_beta_deposits2.68559412
8* MP0004859_abnormal_synaptic_plasticity2.62592537
9MP0001486_abnormal_startle_reflex2.61414997
10MP0005058_abnormal_lysosome_morphology2.53014442
11MP0003172_abnormal_lysosome_physiology2.52681462
12MP0006292_abnormal_olfactory_placode2.34711200
13MP0008260_abnormal_autophagy2.33439813
14MP0005670_abnormal_white_adipose2.26509154
15MP0004742_abnormal_vestibular_system2.25152993
16MP0001188_hyperpigmentation2.25034486
17MP0003880_abnormal_central_pattern2.16774470
18MP0009278_abnormal_bone_marrow2.12426372
19* MP0003635_abnormal_synaptic_transmissio2.10426344
20MP0001485_abnormal_pinna_reflex2.07382323
21MP0004270_analgesia2.07333876
22MP0004885_abnormal_endolymph2.03426369
23MP0003879_abnormal_hair_cell2.02059162
24MP0001348_abnormal_lacrimal_gland2.01178750
25MP0005423_abnormal_somatic_nervous2.00845708
26MP0003787_abnormal_imprinting1.99432567
27MP0000678_abnormal_parathyroid_gland1.96602441
28MP0009745_abnormal_behavioral_response1.95535777
29MP0009840_abnormal_foam_cell1.93766113
30MP0010234_abnormal_vibrissa_follicle1.91435716
31MP0009046_muscle_twitch1.85876135
32MP0005646_abnormal_pituitary_gland1.84625695
33MP0002272_abnormal_nervous_system1.83367520
34MP0001849_ear_inflammation1.81031154
35MP0005409_darkened_coat_color1.76073564
36MP0001986_abnormal_taste_sensitivity1.74609353
37MP0004145_abnormal_muscle_electrophysio1.72271100
38MP0002735_abnormal_chemical_nociception1.71191046
39MP0003941_abnormal_skin_development1.70095446
40MP0002572_abnormal_emotion/affect_behav1.68355110
41MP0002063_abnormal_learning/memory/cond1.67936577
42MP0002249_abnormal_larynx_morphology1.67075224
43MP0002734_abnormal_mechanical_nocicepti1.62546524
44MP0002277_abnormal_respiratory_mucosa1.60157049
45MP0002557_abnormal_social/conspecific_i1.60051305
46MP0000604_amyloidosis1.58655298
47MP0002064_seizures1.55103864
48MP0002184_abnormal_innervation1.53793357
49MP0001440_abnormal_grooming_behavior1.53104281
50MP0003283_abnormal_digestive_organ1.52942711
51MP0001502_abnormal_circadian_rhythm1.51465860
52MP0000569_abnormal_digit_pigmentation1.49922661
53MP0001346_abnormal_lacrimal_gland1.49814542
54MP0000778_abnormal_nervous_system1.47058240
55MP0000003_abnormal_adipose_tissue1.46972088
56MP0004043_abnormal_pH_regulation1.41123439
57MP0002067_abnormal_sensory_capabilities1.40536038
58MP0001968_abnormal_touch/_nociception1.39487152
59MP0001963_abnormal_hearing_physiology1.36918231
60MP0005171_absent_coat_pigmentation1.36231562
61MP0008004_abnormal_stomach_pH1.36024746
62MP0003191_abnormal_cellular_cholesterol1.35007719
63MP0003123_paternal_imprinting1.33622490
64MP0000026_abnormal_inner_ear1.32211017
65MP0000631_abnormal_neuroendocrine_gland1.29157521
66MP0003705_abnormal_hypodermis_morpholog1.28600573
67MP0002102_abnormal_ear_morphology1.27838776
68* MP0003698_abnormal_male_reproductive1.25632335
69MP0003690_abnormal_glial_cell1.25065258
70MP0004133_heterotaxia1.24873895
71MP0005379_endocrine/exocrine_gland_phen1.24622785
72MP0004233_abnormal_muscle_weight1.23522338
73MP0006072_abnormal_retinal_apoptosis1.22773238
74MP0001970_abnormal_pain_threshold1.22631953
75MP0001664_abnormal_digestion1.21147849
76MP0000955_abnormal_spinal_cord1.20514032
77MP0002638_abnormal_pupillary_reflex1.20028696
78MP0003868_abnormal_feces_composition1.19206681
79MP0000579_abnormal_nail_morphology1.16194239
80MP0005375_adipose_tissue_phenotype1.14623063
81MP0006276_abnormal_autonomic_nervous1.13959212
82MP0003136_yellow_coat_color1.13309445
83MP0003634_abnormal_glial_cell1.12209778
84MP0000462_abnormal_digestive_system1.11599108
85MP0005666_abnormal_adipose_tissue1.10777490
86MP0000049_abnormal_middle_ear1.09660029
87MP0000681_abnormal_thyroid_gland1.09497179
88MP0002733_abnormal_thermal_nociception1.09078400
89MP0008874_decreased_physiological_sensi1.08158775
90MP0002882_abnormal_neuron_morphology1.05936775
91MP0003122_maternal_imprinting1.04852356
92MP0002938_white_spotting1.04765196
93MP0002752_abnormal_somatic_nervous1.02468994
94MP0008569_lethality_at_weaning1.02371132
95MP0000762_abnormal_tongue_morphology1.01967565
96MP0001501_abnormal_sleep_pattern1.01505225
97MP0000747_muscle_weakness1.00262139
98MP0004142_abnormal_muscle_tone0.99889033
99MP0003075_altered_response_to0.99790862
100MP0000383_abnormal_hair_follicle0.99240608
101MP0003646_muscle_fatigue0.98171965
102MP0005551_abnormal_eye_electrophysiolog0.98149615
103MP0001765_abnormal_ion_homeostasis0.97165124
104MP0000920_abnormal_myelination0.96389571
105MP0002822_catalepsy0.95745973
106MP0002089_abnormal_postnatal_growth/wei0.95543401
107MP0002066_abnormal_motor_capabilities/c0.95010424
108MP0002736_abnormal_nociception_after0.94733988
109MP0000751_myopathy0.94705448
110MP0002229_neurodegeneration0.94275923
111MP0002693_abnormal_pancreas_physiology0.93951576
112MP0001984_abnormal_olfaction0.93552599
113MP0005220_abnormal_exocrine_pancreas0.92017711
114MP0009697_abnormal_copulation0.89778185
115MP0009780_abnormal_chondrocyte_physiolo0.88655159
116MP0004924_abnormal_behavior0.88056815
117MP0005386_behavior/neurological_phenoty0.88056815
118MP0005535_abnormal_body_temperature0.86627165
119MP0004947_skin_inflammation0.86010420
120MP0002653_abnormal_ependyma_morphology0.85574628
121MP0000537_abnormal_urethra_morphology0.84939683
122MP0002796_impaired_skin_barrier0.84898162
123MP0000613_abnormal_salivary_gland0.84522632
124MP0005174_abnormal_tail_pigmentation0.83553511
125MP0004085_abnormal_heartbeat0.83077134
126MP0003631_nervous_system_phenotype0.82050717
127MP0004811_abnormal_neuron_physiology0.81901741
128MP0005167_abnormal_blood-brain_barrier0.81731734
129MP0003633_abnormal_nervous_system0.80908587
130MP0005310_abnormal_salivary_gland0.80562324
131MP0004858_abnormal_nervous_system0.80043689
132MP0000470_abnormal_stomach_morphology0.80030297
133MP0002909_abnormal_adrenal_gland0.80015529
134MP0001293_anophthalmia0.79929147
135MP0004381_abnormal_hair_follicle0.79581676
136MP0000467_abnormal_esophagus_morphology0.79479332
137MP0003183_abnormal_peptide_metabolism0.78205189
138* MP0002161_abnormal_fertility/fecundity0.77161968
139MP0001905_abnormal_dopamine_level0.76915433
140MP0005253_abnormal_eye_physiology0.76294428
141MP0002233_abnormal_nose_morphology0.75749170
142MP0002751_abnormal_autonomic_nervous0.74669173
143MP0004782_abnormal_surfactant_physiolog0.74465995
144MP0000013_abnormal_adipose_tissue0.73418971
145MP0001270_distended_abdomen0.72073864
146MP0002098_abnormal_vibrissa_morphology0.68941268
147MP0004510_myositis0.67828162
148MP0003453_abnormal_keratinocyte_physiol0.67548571

Predicted human phenotypes

RankGene SetZ-score
1Unilateral renal agenesis (HP:0000122)4.11102496
2Dynein arm defect of respiratory motile cilia (HP:0012255)3.75706497
3Absent/shortened dynein arms (HP:0200106)3.75706497
4Hyperphosphatemia (HP:0002905)3.60047267
5Supranuclear gaze palsy (HP:0000605)3.58076741
6Distal upper limb amyotrophy (HP:0007149)3.47481969
7Upper limb amyotrophy (HP:0009129)3.47481969
8Obstructive sleep apnea (HP:0002870)3.44834327
9Absent eyebrow (HP:0002223)3.36965594
10Stridor (HP:0010307)3.31827417
11Focal motor seizures (HP:0011153)3.27427996
12Asymmetric septal hypertrophy (HP:0001670)3.24101831
13Febrile seizures (HP:0002373)3.19726001
14Hand muscle atrophy (HP:0009130)3.15867841
15Hyperacusis (HP:0010780)3.11698231
16Neurofibrillary tangles (HP:0002185)3.11017623
17Congenital sensorineural hearing impairment (HP:0008527)2.99314117
18Parakeratosis (HP:0001036)2.96255282
19Cerebral inclusion bodies (HP:0100314)2.92584710
20Abnormality of calcium-phosphate metabolism (HP:0100530)2.92140868
21Metabolic alkalosis (HP:0200114)2.85824598
22Septo-optic dysplasia (HP:0100842)2.83329597
23Osteomalacia (HP:0002749)2.77367034
24Neuronal loss in central nervous system (HP:0002529)2.73833267
25Postural instability (HP:0002172)2.71558772
26Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.68134050
27Spastic gait (HP:0002064)2.60574116
28Hyperthyroidism (HP:0000836)2.58014934
29Cheilitis (HP:0100825)2.52973993
30White forelock (HP:0002211)2.50552629
31Abnormality of the aortic arch (HP:0012303)2.49800267
32Cerebral hypomyelination (HP:0006808)2.49516240
33Peripheral hypomyelination (HP:0007182)2.47401293
34Visual hallucinations (HP:0002367)2.46422924
35Chronic hepatic failure (HP:0100626)2.44318063
36Prolonged QT interval (HP:0001657)2.44029075
37Lip pit (HP:0100267)2.43624104
38Popliteal pterygium (HP:0009756)2.42839604
39Epileptic encephalopathy (HP:0200134)2.42017551
40Difficulty climbing stairs (HP:0003551)2.40647557
41Resting tremor (HP:0002322)2.38025784
42Absent eyelashes (HP:0000561)2.37600582
43Amelogenesis imperfecta (HP:0000705)2.33351682
44Patchy hypopigmentation of hair (HP:0011365)2.31996220
45Depression (HP:0000716)2.31672810
46Dysmetria (HP:0001310)2.31124123
47Tubulointerstitial nephritis (HP:0001970)2.29256766
48Hyperaldosteronism (HP:0000859)2.29202294
49Bronchomalacia (HP:0002780)2.28890370
50Abnormal ciliary motility (HP:0012262)2.28294407
51Optic nerve hypoplasia (HP:0000609)2.26919165
52Cutaneous finger syndactyly (HP:0010554)2.26806725
53Aplasia cutis congenita (HP:0001057)2.26441532
54Hyperactive renin-angiotensin system (HP:0000841)2.24766121
55Abnormality of polysaccharide metabolism (HP:0011012)2.24348321
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24348321
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24348321
58Decreased central vision (HP:0007663)2.22207863
59Rapidly progressive (HP:0003678)2.21750027
60Distal lower limb amyotrophy (HP:0008944)2.21287140
61Bowel incontinence (HP:0002607)2.19427774
62Gaze-evoked nystagmus (HP:0000640)2.19133309
63Atelectasis (HP:0100750)2.18501541
64Abnormal respiratory epithelium morphology (HP:0012253)2.18117985
65Abnormal respiratory motile cilium morphology (HP:0005938)2.18117985
66Hypoplastic ischia (HP:0003175)2.17797388
67Abnormality of renin-angiotensin system (HP:0000847)2.17124219
68Truncus arteriosus (HP:0001660)2.16331662
69Amblyopia (HP:0000646)2.15300700
70Absent speech (HP:0001344)2.14855765
71Pancreatic fibrosis (HP:0100732)2.14711111
72Intention tremor (HP:0002080)2.14311863
73Exercise-induced myalgia (HP:0003738)2.14284881
74Hyperkalemia (HP:0002153)2.13959235
75Broad face (HP:0000283)2.13436671
76Achilles tendon contracture (HP:0001771)2.12142981
77Abnormality of the periventricular white matter (HP:0002518)2.10786044
78Mucopolysacchariduria (HP:0008155)2.09770959
79Urinary glycosaminoglycan excretion (HP:0003541)2.09770959
80Absent septum pellucidum (HP:0001331)2.09394267
81Centrally nucleated skeletal muscle fibers (HP:0003687)2.08499044
82J-shaped sella turcica (HP:0002680)2.08186495
83Myopathic facies (HP:0002058)2.07563629
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.07297027
85Axonal loss (HP:0003447)2.05827731
86Flattened epiphyses (HP:0003071)2.04671367
87Myokymia (HP:0002411)2.04397959
88Broad-based gait (HP:0002136)2.04126686
89Delusions (HP:0000746)2.03773969
90Abnormal EKG (HP:0003115)2.03723529
91Cerebral aneurysm (HP:0004944)2.03678873
92Syncope (HP:0001279)2.03574385
93Insomnia (HP:0100785)2.02906051
94Alacrima (HP:0000522)2.02471789
95Renal dysplasia (HP:0000110)2.02429798
96Urinary urgency (HP:0000012)2.02347080
97Decreased circulating renin level (HP:0003351)2.01995120
98Focal seizures (HP:0007359)2.01411609
99Distal lower limb muscle weakness (HP:0009053)2.01405730
100Hyperventilation (HP:0002883)2.01375206
101Abnormality of the renal medulla (HP:0100957)2.01195641
102Dysostosis multiplex (HP:0000943)1.98933326
103Microvesicular hepatic steatosis (HP:0001414)1.98735178
104Abnormal large intestine physiology (HP:0012700)1.96814284
105Ankle clonus (HP:0011448)1.96758953
106Abnormality of dental color (HP:0011073)1.96718103
107Abnormality of the ischium (HP:0003174)1.96710487
108Abnormality of potassium homeostasis (HP:0011042)1.95769347
109Precocious puberty (HP:0000826)1.95498703
110Cutaneous syndactyly (HP:0012725)1.94706335
111Growth hormone excess (HP:0000845)1.93589421
112Nuclear cataract (HP:0100018)1.92792147
113Overriding aorta (HP:0002623)1.92319220
114Abnormal respiratory motile cilium physiology (HP:0012261)1.91473164
115Truncal ataxia (HP:0002078)1.91397305
116Lower limb amyotrophy (HP:0007210)1.91344026
117Apathy (HP:0000741)1.91262159
118Severe visual impairment (HP:0001141)1.89859845
119Nephronophthisis (HP:0000090)1.89349937
120Rigidity (HP:0002063)1.89202240
121Abnormality of the Achilles tendon (HP:0005109)1.89066789
122Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87625065
123Interstitial pulmonary disease (HP:0006530)1.86850509
124Anomalous pulmonary venous return (HP:0010772)1.86744287
125Alopecia of scalp (HP:0002293)1.86578538
126Decreased lacrimation (HP:0000633)1.86418039
127Abnormality of the renal collecting system (HP:0004742)1.86143041
128Elfin facies (HP:0004428)1.86049377
129Clonus (HP:0002169)1.86031081
130Personality changes (HP:0000751)1.85693603
131Protruding tongue (HP:0010808)1.84889865
132Atrial fibrillation (HP:0005110)1.84730891
133Akinesia (HP:0002304)1.83931584
134Diminished motivation (HP:0000745)1.82996051
135Myelomeningocele (HP:0002475)1.82903481
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82320259
137Annular pancreas (HP:0001734)1.82271556
138Flat acetabular roof (HP:0003180)1.81872184
139Pointed chin (HP:0000307)1.81660684
140Large eyes (HP:0001090)1.81374346
141Nonprogressive disorder (HP:0003680)1.81249308
142Thin bony cortex (HP:0002753)1.81202975
143Hypokalemia (HP:0002900)1.80334017
144Urinary bladder sphincter dysfunction (HP:0002839)1.80122238
145Bradykinesia (HP:0002067)1.80006939
146Abnormality of the renal cortex (HP:0011035)1.79381324
147Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79100657
148Neonatal onset (HP:0003623)1.78993864
149Urinary incontinence (HP:0000020)1.78159936
150Action tremor (HP:0002345)1.77842731
151Renal agenesis (HP:0000104)1.76490542
152Turricephaly (HP:0000262)1.76356984
153Abnormality of the thoracic spine (HP:0100711)1.76123872
154Blue irides (HP:0000635)1.75914693
155Upper limb muscle weakness (HP:0003484)1.74710719
156Slow saccadic eye movements (HP:0000514)1.74472270
157Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74366323
158Bulbar palsy (HP:0001283)1.73973050
159Ventricular tachycardia (HP:0004756)1.73889896
160Gastroesophageal reflux (HP:0002020)1.73102380
161Onion bulb formation (HP:0003383)1.72585511
162Lower limb muscle weakness (HP:0007340)1.71437885
163Dementia (HP:0000726)1.71300995
164Thoracic kyphosis (HP:0002942)1.71161735
165Oligodontia (HP:0000677)1.70986948
166Increased cerebral lipofuscin (HP:0011813)1.70837103
167EMG: neuropathic changes (HP:0003445)1.70668435
168Renovascular hypertension (HP:0100817)1.70088842
169Male infertility (HP:0003251)1.69813925
170Cervical subluxation (HP:0003308)1.69810775
171Tetany (HP:0001281)1.68766311
172Loss of speech (HP:0002371)1.68757206
173Muscle hypertrophy of the lower extremities (HP:0008968)1.68692816
174Acanthosis nigricans (HP:0000956)1.68660751
175Abnormality of the septum pellucidum (HP:0007375)1.68222746
176Bell-shaped thorax (HP:0001591)1.67475077
177Germ cell neoplasia (HP:0100728)1.67445660
178Duplicated collecting system (HP:0000081)1.67391185
179Recurrent corneal erosions (HP:0000495)1.65721516
180Primary atrial arrhythmia (HP:0001692)1.65525553
181Generalized tonic-clonic seizures (HP:0002069)1.64025645
182Tented upper lip vermilion (HP:0010804)1.63447461
183Renal cortical cysts (HP:0000803)1.63174366
184Mixed hearing impairment (HP:0000410)1.62630215
185Limited hip movement (HP:0008800)1.61901760
186Polycystic kidney dysplasia (HP:0000113)1.61671197
187Chromosomal breakage induced by crosslinking agents (HP:0003221)1.61399770
188Maternal diabetes (HP:0009800)1.61126804
189Intestinal atresia (HP:0011100)1.61012605
190Ectopic anus (HP:0004397)1.59277456
191Symptomatic seizures (HP:0011145)1.58748629
192Hypocalcemia (HP:0002901)1.57317455
193Flat cornea (HP:0007720)1.57246069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.71555602
2TRIB34.16884859
3SIK23.68831081
4TNIK3.12410479
5INSRR2.98500170
6TESK12.95221492
7NTRK32.91146748
8MAP3K112.87024355
9EPHA42.76480398
10SIK12.56656058
11EPHA22.44667151
12MAPK152.33167548
13MAP3K132.25540826
14MAP2K72.12067310
15EEF2K2.03952030
16ERN12.03384471
17MARK12.02532674
18CASK1.99072599
19RIPK11.93213668
20BRD41.90285829
21SMG11.78535879
22MAPK131.78267180
23MST1R1.76990694
24NTRK21.68263208
25MARK21.66553645
26PRPF4B1.62423958
27CAMKK11.60006694
28PHKG21.57926621
29PHKG11.57926621
30ARAF1.50092696
31TESK21.49775475
32ADRBK21.48081847
33GRK71.43366804
34RPS6KA21.37047853
35NEK61.35585537
36WNK11.35579001
37MAP3K11.32618174
38MAP2K21.31885742
39PKN21.26964598
40EPHB11.26680444
41DMPK1.26410907
42PINK11.26312959
43PDPK11.24506513
44UHMK11.20033559
45CDC42BPA1.16277760
46ICK1.14934730
47CDK191.13031844
48STK381.11382785
49STK391.10445432
50PKN11.10091523
51MARK31.08288226
52CAMK11.07877663
53DYRK1B1.07249111
54RIPK41.06394508
55NME21.03387432
56MAP3K71.00992302
57DAPK21.00176525
58AKT30.98273738
59CAMK1G0.97371763
60NUAK10.96933904
61MKNK20.95491189
62MAP3K40.93992522
63PDK10.93824535
64MTOR0.92986467
65KSR20.91021158
66FGFR40.90782577
67TAOK10.88533082
68WNK40.88231185
69OBSCN0.87307095
70TNK20.86069074
71ZAK0.85514395
72OXSR10.84588865
73YES10.83710365
74IRAK30.83401116
75TYRO30.82277161
76CSNK1A1L0.80552523
77PRKD30.80188925
78RPS6KL10.80161536
79RPS6KC10.80161536
80HIPK20.80127958
81CDK30.80058148
82SGK2230.80047657
83SGK4940.80047657
84LMTK20.77988577
85MAP3K90.75409358
86MAP4K10.71384739
87WNK30.71135063
88MET0.70956098
89MINK10.70259102
90CDK50.70034346
91STK38L0.69875188
92SGK20.69442368
93PRKG20.69027396
94MUSK0.67771376
95DYRK1A0.67458321
96CAMK40.67162520
97MAP3K60.67126155
98LATS10.66465624
99PRKG10.66378093
100TBK10.64444653
101PAK60.64194695
102PRKCH0.62832219
103SGK10.62702180
104RPS6KA60.62487498
105CDK80.60015533
106DDR20.59948626
107MAP2K60.59472563
108TTN0.58951020
109PTK60.58295927
110MAP2K30.58067675
111PIK3CA0.57828507
112RPS6KA10.57318715
113PRKCG0.57056877
114DAPK10.55764409
115PRKAA20.54328358
116ALK0.53654025
117BCKDK0.53504137
118PIM20.53172363
119BRAF0.53150489
120PNCK0.52752306
121CSNK1G20.52440656
122MAPK80.51264937
123TGFBR20.50198167
124CAMK2D0.49854686
125MAPK100.49377361
126PAK30.48544045
127CAMK2A0.47371683
128PRKD20.47063355
129MAP3K30.46509141
130GRK60.46310673
131PRKAA10.46190571
132ERBB20.46095513
133PRKCE0.46063002
134LATS20.46047752
135SRPK10.45716623
136NTRK10.45299900
137ERBB30.45083334
138RET0.44776407
139IRAK20.44644008
140CAMK1D0.44055717
141CDK120.43479344
142PTK20.42447836
143CAMK2B0.42404859
144MAPK120.41825505
145PASK0.41752644
146PRKCZ0.41019342
147CSNK1D0.40729396
148CAMK2G0.39821429
149GRK10.39521177
150MAP2K40.39491550
151MATK0.38817701
152NME10.38666737
153DYRK20.38522895
154CDK11A0.37202151
155SGK30.37053395
156GSK3B0.34828929

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.35388514
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.60290032
3Insulin secretion_Homo sapiens_hsa049112.51963631
4Taste transduction_Homo sapiens_hsa047422.48788032
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25916937
6Glutamatergic synapse_Homo sapiens_hsa047242.23579696
7Circadian entrainment_Homo sapiens_hsa047132.21729269
8Morphine addiction_Homo sapiens_hsa050322.21136814
9Pancreatic secretion_Homo sapiens_hsa049722.06454932
10GABAergic synapse_Homo sapiens_hsa047272.06332725
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.98948572
12Calcium signaling pathway_Homo sapiens_hsa040201.95325308
13Other glycan degradation_Homo sapiens_hsa005111.91617768
14Type II diabetes mellitus_Homo sapiens_hsa049301.84351212
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79849060
16Olfactory transduction_Homo sapiens_hsa047401.79664529
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.77481126
18Serotonergic synapse_Homo sapiens_hsa047261.74602214
19Amphetamine addiction_Homo sapiens_hsa050311.74154830
20Cocaine addiction_Homo sapiens_hsa050301.70927200
21Phenylalanine metabolism_Homo sapiens_hsa003601.70251971
22Axon guidance_Homo sapiens_hsa043601.69238548
23Salivary secretion_Homo sapiens_hsa049701.63350055
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62880991
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.62818886
26Synaptic vesicle cycle_Homo sapiens_hsa047211.60006820
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.57045352
28Cholinergic synapse_Homo sapiens_hsa047251.55375110
29Arginine biosynthesis_Homo sapiens_hsa002201.54006777
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.50783683
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50327050
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50132618
33Gastric acid secretion_Homo sapiens_hsa049711.49473075
34Long-term potentiation_Homo sapiens_hsa047201.46578427
35Renin secretion_Homo sapiens_hsa049241.44335203
36Circadian rhythm_Homo sapiens_hsa047101.42736946
37VEGF signaling pathway_Homo sapiens_hsa043701.35040419
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33483584
39cAMP signaling pathway_Homo sapiens_hsa040241.33076383
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32930826
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31895767
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29804106
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29264994
44Dopaminergic synapse_Homo sapiens_hsa047281.25431855
45Oxytocin signaling pathway_Homo sapiens_hsa049211.22558853
46Sulfur relay system_Homo sapiens_hsa041221.20907543
47Phototransduction_Homo sapiens_hsa047441.19789178
48Vitamin B6 metabolism_Homo sapiens_hsa007501.19621885
49Long-term depression_Homo sapiens_hsa047301.14399370
50Dilated cardiomyopathy_Homo sapiens_hsa054141.12832447
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12034621
52AMPK signaling pathway_Homo sapiens_hsa041521.09381500
53Endocytosis_Homo sapiens_hsa041441.08547226
54Acute myeloid leukemia_Homo sapiens_hsa052211.06840769
55Insulin signaling pathway_Homo sapiens_hsa049101.06596581
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05616679
57Wnt signaling pathway_Homo sapiens_hsa043101.05550150
58Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03485182
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03051212
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01064048
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00100841
62Sphingolipid metabolism_Homo sapiens_hsa006000.99126112
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98137257
64Protein digestion and absorption_Homo sapiens_hsa049740.98058822
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.97799847
66Lysosome_Homo sapiens_hsa041420.96790256
67ErbB signaling pathway_Homo sapiens_hsa040120.96084147
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95160516
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94161509
70mTOR signaling pathway_Homo sapiens_hsa041500.93567130
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93248721
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90166947
73Ether lipid metabolism_Homo sapiens_hsa005650.89928458
74Bile secretion_Homo sapiens_hsa049760.88040416
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87375359
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.86409018
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85712133
78Mineral absorption_Homo sapiens_hsa049780.85217721
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.85179107
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83312769
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81684989
82Fatty acid metabolism_Homo sapiens_hsa012120.80603069
83Cardiac muscle contraction_Homo sapiens_hsa042600.79711796
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78747732
85Dorso-ventral axis formation_Homo sapiens_hsa043200.78354767
86Notch signaling pathway_Homo sapiens_hsa043300.77571060
87Glioma_Homo sapiens_hsa052140.74968749
88Ovarian steroidogenesis_Homo sapiens_hsa049130.74918309
89Glucagon signaling pathway_Homo sapiens_hsa049220.73722093
90Ras signaling pathway_Homo sapiens_hsa040140.73474285
91Lysine degradation_Homo sapiens_hsa003100.73149888
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72861370
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72755856
94Histidine metabolism_Homo sapiens_hsa003400.71990328
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71259437
96Melanogenesis_Homo sapiens_hsa049160.70755711
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70360704
98Vibrio cholerae infection_Homo sapiens_hsa051100.70137812
99Prion diseases_Homo sapiens_hsa050200.68974681
100Biosynthesis of amino acids_Homo sapiens_hsa012300.68049373
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.67076236
102Basal cell carcinoma_Homo sapiens_hsa052170.66145802
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.66108690
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65129949
105Insulin resistance_Homo sapiens_hsa049310.63956153
106Hedgehog signaling pathway_Homo sapiens_hsa043400.63752143
107Fatty acid biosynthesis_Homo sapiens_hsa000610.63574897
108Pentose phosphate pathway_Homo sapiens_hsa000300.62910250
109MAPK signaling pathway_Homo sapiens_hsa040100.62304192
110GnRH signaling pathway_Homo sapiens_hsa049120.62231278
111Gap junction_Homo sapiens_hsa045400.61630068
112Non-small cell lung cancer_Homo sapiens_hsa052230.60499034
113PPAR signaling pathway_Homo sapiens_hsa033200.59587743
114Melanoma_Homo sapiens_hsa052180.57593417
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56777210
116Estrogen signaling pathway_Homo sapiens_hsa049150.56307618
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56122569
118Tight junction_Homo sapiens_hsa045300.55148750
119Inositol phosphate metabolism_Homo sapiens_hsa005620.52894228
120Carbon metabolism_Homo sapiens_hsa012000.52533201
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51265309
122Rap1 signaling pathway_Homo sapiens_hsa040150.51172932
123Choline metabolism in cancer_Homo sapiens_hsa052310.50673443
124ABC transporters_Homo sapiens_hsa020100.50036896
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49624055
126Arginine and proline metabolism_Homo sapiens_hsa003300.48599130
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46917576
128Fanconi anemia pathway_Homo sapiens_hsa034600.45901530
129Linoleic acid metabolism_Homo sapiens_hsa005910.45443234
130Endometrial cancer_Homo sapiens_hsa052130.44379547
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.41937238
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39817969
133Protein export_Homo sapiens_hsa030600.39562954
134Prolactin signaling pathway_Homo sapiens_hsa049170.38931335
135Thyroid hormone synthesis_Homo sapiens_hsa049180.36162881
136Renal cell carcinoma_Homo sapiens_hsa052110.34105551
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.33835137
138Vitamin digestion and absorption_Homo sapiens_hsa049770.33651714
139Fat digestion and absorption_Homo sapiens_hsa049750.32737508
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30051845
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29975268
142Fructose and mannose metabolism_Homo sapiens_hsa000510.29304026
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27993825

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