PI4KB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of histone H3-K27 methylation (GO:0061085)8.32583702
2interferon-gamma production (GO:0032609)6.79784941
3presynaptic membrane assembly (GO:0097105)6.52800305
4regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)6.20214350
5postsynaptic membrane organization (GO:0001941)6.12561778
6mature B cell differentiation (GO:0002335)5.71712009
7Golgi to endosome transport (GO:0006895)5.60569905
8positive regulation of gamma-delta T cell activation (GO:0046645)5.28743637
9Golgi transport vesicle coating (GO:0048200)4.97222295
10COPI coating of Golgi vesicle (GO:0048205)4.97222295
11presynaptic membrane organization (GO:0097090)4.95817363
12regulation of metalloenzyme activity (GO:0048552)4.90402010
13mannose metabolic process (GO:0006013)4.78500555
14protein heterotetramerization (GO:0051290)4.63757610
15generation of neurons (GO:0048699)4.38659934
16regulation of stem cell maintenance (GO:2000036)4.32400491
17positive regulation of natural killer cell mediated immunity (GO:0002717)4.07953891
18positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.07953891
19neurotransmitter-gated ion channel clustering (GO:0072578)4.00343411
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.99173390
21regulation of natural killer cell mediated immunity (GO:0002715)3.97989232
22regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.97989232
23omega-hydroxylase P450 pathway (GO:0097267)3.94527147
24cellular response to exogenous dsRNA (GO:0071360)3.78953236
25negative T cell selection (GO:0043383)3.69888175
26protein localization to endosome (GO:0036010)3.68523527
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.66432271
28regulation of gamma-delta T cell activation (GO:0046643)3.63109419
29viral transcription (GO:0019083)3.61240633
30regulation of B cell receptor signaling pathway (GO:0050855)3.60798067
31negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.58388013
32negative regulation of T-helper cell differentiation (GO:0045623)3.58388013
33regulation of gamma-delta T cell differentiation (GO:0045586)3.58041093
34positive thymic T cell selection (GO:0045059)3.57084002
35response to folic acid (GO:0051593)3.56286235
36positive T cell selection (GO:0043368)3.49629563
37barbed-end actin filament capping (GO:0051016)3.47124817
38negative thymic T cell selection (GO:0045060)3.44643299
39positive regulation of response to tumor cell (GO:0002836)3.44178926
40positive regulation of immune response to tumor cell (GO:0002839)3.44178926
41regulation of immune response to tumor cell (GO:0002837)3.44178926
42regulation of response to tumor cell (GO:0002834)3.44178926
43negative regulation of cell size (GO:0045792)3.41871739
44positive regulation of systemic arterial blood pressure (GO:0003084)3.39159426
45negative regulation of cell killing (GO:0031342)3.30709443
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.30709443
47translational termination (GO:0006415)3.25173242
48regulation of T-helper 1 cell differentiation (GO:0045625)3.24548745
49regulation of T-helper 2 cell differentiation (GO:0045628)3.23958585
50positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.23208570
51negative regulation of phagocytosis (GO:0050765)3.22483604
52thymic T cell selection (GO:0045061)3.20652585
53regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.19587369
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.16907156
553-UTR-mediated mRNA stabilization (GO:0070935)3.16689159
56positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.15920665
57positive regulation of osteoclast differentiation (GO:0045672)3.14683155
58negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.12011899
59positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08636641
60SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.07426740
61regulation of ruffle assembly (GO:1900027)3.06854793
62stress fiber assembly (GO:0043149)3.06046220
63negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.04880772
64T cell selection (GO:0045058)3.04006590
65regulation of leukocyte mediated cytotoxicity (GO:0001910)3.02918653
66negative regulation of type 2 immune response (GO:0002829)3.02337220
67mature B cell differentiation involved in immune response (GO:0002313)3.01390046
68protein targeting to ER (GO:0045047)3.01389918
69melanin metabolic process (GO:0006582)2.96731675
70cotranslational protein targeting to membrane (GO:0006613)2.96213481
71mast cell activation (GO:0045576)2.95677174
72response to laminar fluid shear stress (GO:0034616)2.94021631
73NIK/NF-kappaB signaling (GO:0038061)2.94010187
74positive regulation of Cdc42 GTPase activity (GO:0043089)2.93886409
75anterior/posterior axis specification, embryo (GO:0008595)2.91565993
76negative regulation of alpha-beta T cell differentiation (GO:0046639)2.91547594
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.90336086
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.90336086
79cellular defense response (GO:0006968)2.88816276
80positive regulation of neurotransmitter secretion (GO:0001956)2.88705440
81adherens junction assembly (GO:0034333)2.88554451
82positive regulation of cell killing (GO:0031343)2.87535009
83pinocytosis (GO:0006907)2.86855440
84intracellular estrogen receptor signaling pathway (GO:0030520)2.86073730
85protein localization to endoplasmic reticulum (GO:0070972)2.85824195
86focal adhesion assembly (GO:0048041)2.85378177
87cell-substrate adherens junction assembly (GO:0007045)2.85378177
88amyloid precursor protein catabolic process (GO:0042987)2.84654382
89spliceosomal tri-snRNP complex assembly (GO:0000244)2.84630320
90activation of Rac GTPase activity (GO:0032863)2.84107062
91establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83456050
92ribosomal small subunit biogenesis (GO:0042274)2.82387619
93regulation of type I interferon-mediated signaling pathway (GO:0060338)2.81992106
94protein retention in ER lumen (GO:0006621)2.81923175
95positive regulation of cellular amide metabolic process (GO:0034250)2.81152415
96cellular extravasation (GO:0045123)2.80995614
97dendritic cell chemotaxis (GO:0002407)2.80387470
98adult heart development (GO:0007512)2.80116481
99negative regulation of erythrocyte differentiation (GO:0045647)2.80019002
100maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.77082898
101facial nerve structural organization (GO:0021612)2.77002189
102modulation by symbiont of host cellular process (GO:0044068)2.76973802
103positive regulation of humoral immune response (GO:0002922)2.75232841
104Arp2/3 complex-mediated actin nucleation (GO:0034314)2.72158872
105negative regulation of metanephros development (GO:0072217)2.72111222
106response to peptidoglycan (GO:0032494)2.72083559
107myeloid dendritic cell activation (GO:0001773)2.72007576
108cellular modified amino acid catabolic process (GO:0042219)2.71816369
109regulation of cell killing (GO:0031341)2.71436452
110activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.69447901
111epithelial cell differentiation involved in prostate gland development (GO:0060742)2.68709620
112antigen processing and presentation of endogenous antigen (GO:0019883)2.68428425
113hepatocyte apoptotic process (GO:0097284)2.66876595
114modulation by symbiont of host defense response (GO:0052031)2.66709179
115modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.66709179
116modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.66709179
117positive regulation by organism of defense response of other organism involved in symbiotic interact2.66709179
118modulation by symbiont of host immune response (GO:0052553)2.66709179
119positive regulation by symbiont of host defense response (GO:0052509)2.66709179
120negative regulation of inclusion body assembly (GO:0090084)2.65837699
121positive regulation of defense response to virus by host (GO:0002230)2.63940686
122pentose-phosphate shunt (GO:0006098)2.63685854
123regulation of defense response to virus by virus (GO:0050690)2.61500661
124radial glial cell differentiation (GO:0060019)2.61160733
125modulation by virus of host process (GO:0019054)2.60966764
126ribosomal small subunit assembly (GO:0000028)2.60767637
127membrane assembly (GO:0071709)2.60583286
128vesicle targeting (GO:0006903)2.59873873
129positive regulation of blood vessel endothelial cell migration (GO:0043536)2.56365145
130regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.56322519
131positive regulation of receptor recycling (GO:0001921)2.55623897
132detection of other organism (GO:0098543)2.55556119
133positive regulation of nuclease activity (GO:0032075)2.54496474
134serine family amino acid catabolic process (GO:0009071)2.54113136
135retrograde transport, endosome to Golgi (GO:0042147)2.54004807
136definitive hemopoiesis (GO:0060216)2.53680241
137positive regulation of B cell differentiation (GO:0045579)2.53628069
138response to muramyl dipeptide (GO:0032495)2.52967624
139positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.52905328
140detection of bacterium (GO:0016045)2.52668065
141regulation of B cell differentiation (GO:0045577)2.52083944
142negative regulation of viral release from host cell (GO:1902187)2.50933370
143embryonic process involved in female pregnancy (GO:0060136)2.48148002
144regulation of early endosome to late endosome transport (GO:2000641)2.48113000
145regulation of leukocyte degranulation (GO:0043300)2.46271915
146negative regulation of necroptotic process (GO:0060546)2.44312838
147regulation of ARF protein signal transduction (GO:0032012)2.43987757
148vesicle coating (GO:0006901)2.43176924
149regulation of extracellular matrix disassembly (GO:0010715)2.42395501
150skin morphogenesis (GO:0043589)2.42301953
151regulation of necrotic cell death (GO:0010939)2.42162065
152cell-substrate junction assembly (GO:0007044)2.41647923
153cellular response to virus (GO:0098586)2.41597635
154endoplasmic reticulum unfolded protein response (GO:0030968)2.38306839
155regulation of NFAT protein import into nucleus (GO:0051532)2.38068303
156positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.37270269
157negative regulation of necrotic cell death (GO:0060547)2.36655593
158cytoskeletal anchoring at plasma membrane (GO:0007016)2.36304862
159amyloid precursor protein metabolic process (GO:0042982)2.35010352
160activation of JUN kinase activity (GO:0007257)2.34942672
161regulation of necroptotic process (GO:0060544)2.34942656
162regulation of glucose import in response to insulin stimulus (GO:2001273)2.34915447
163endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.34722263
164basement membrane organization (GO:0071711)2.34492332
165maternal placenta development (GO:0001893)2.33535669
166lipopolysaccharide-mediated signaling pathway (GO:0031663)2.33009573
167positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.32587535
168positive regulation of protein dephosphorylation (GO:0035307)2.29972828
169negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.29751401
170regulation of nuclease activity (GO:0032069)2.27607468
171regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.27317887
172negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.27125148
173macrophage activation involved in immune response (GO:0002281)2.26269301
174leukocyte aggregation (GO:0070486)2.26115446
175histone H3-K36 demethylation (GO:0070544)2.25646382
176response to host (GO:0075136)2.25254207
177response to host defenses (GO:0052200)2.25254207
178response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.25254207
179regulation of macrophage cytokine production (GO:0010935)2.24788044
180regulation of interferon-beta biosynthetic process (GO:0045357)2.24582094
181germinal center formation (GO:0002467)2.24227109
182ER-nucleus signaling pathway (GO:0006984)2.21859383
183modulation by virus of host morphology or physiology (GO:0019048)2.21439803
184negative regulation of skeletal muscle tissue development (GO:0048642)2.20144237
185response to type I interferon (GO:0034340)2.19577756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.03762639
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.73906244
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.38382345
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.62405425
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.36870191
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.32177764
7FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.08704434
8* MAF_26560356_Chip-Seq_TH1_Human2.97090162
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.87799626
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.84594677
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.82713592
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80407007
13RUNX_20019798_ChIP-Seq_JUKART_Human2.80188095
14MYB_26560356_Chip-Seq_TH2_Human2.74582157
15MYC_22102868_ChIP-Seq_BL_Human2.72601771
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.57370147
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.52948765
18SCL_19346495_ChIP-Seq_HPC-7_Human2.52190440
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.50786240
20LXR_22292898_ChIP-Seq_THP-1_Human2.48555325
21IRF1_19129219_ChIP-ChIP_H3396_Human2.47713289
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41719068
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.37933652
24MYB_26560356_Chip-Seq_TH1_Human2.33262999
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.29752087
26* UTX_26944678_Chip-Seq_JUKART_Human2.28486487
27VDR_24763502_ChIP-Seq_THP-1_Human2.28361716
28* RACK7_27058665_Chip-Seq_MCF-7_Human2.22986492
29TP63_17297297_ChIP-ChIP_HaCaT_Human2.19180957
30GATA1_22025678_ChIP-Seq_K562_Human2.19033039
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18504386
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01294127
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00699675
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93133757
35VDR_21846776_ChIP-Seq_THP-1_Human1.92558053
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.90426961
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89550796
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89123885
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89103608
40PU_27001747_Chip-Seq_BMDM_Mouse1.88875570
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.88637108
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.87433321
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.87284226
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.87187541
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85033374
46SPI1_23547873_ChIP-Seq_NB4_Human1.83135349
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81002440
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79304297
49TCF7_22412390_ChIP-Seq_EML_Mouse1.76850019
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75621499
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74983675
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.71325825
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69922274
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.69574133
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.68889843
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67755248
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.66370405
58CLOCK_20551151_ChIP-Seq_293T_Human1.60783795
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.57959085
60VDR_24787735_ChIP-Seq_THP-1_Human1.55771571
61KDM2B_26808549_Chip-Seq_K562_Human1.55177060
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50682187
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50452396
64* MAF_26560356_Chip-Seq_TH2_Human1.49496394
65* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49083340
66* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48343417
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48130355
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47881009
69ZNF263_19887448_ChIP-Seq_K562_Human1.46848162
70* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46503075
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46077181
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45730766
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44822324
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44456023
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44332834
76PKCTHETA_26484144_Chip-Seq_BREAST_Human1.43905578
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42568517
78* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42075051
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39828805
80GATA3_27048872_Chip-Seq_THYMUS_Human1.39415784
81SPI1_23127762_ChIP-Seq_K562_Human1.38643819
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.37910896
83* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36388137
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.36019286
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35109729
86* SA1_27219007_Chip-Seq_ERYTHROID_Human1.35030269
87CDX2_20551321_ChIP-Seq_CACO-2_Human1.33944481
88SMC4_20622854_ChIP-Seq_HELA_Human1.33552112
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33225799
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32906190
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32568434
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32430754
93P68_20966046_ChIP-Seq_HELA_Human1.32234744
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31408492
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.31307971
96GATA2_21666600_ChIP-Seq_HMVEC_Human1.31160939
97* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30689966
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30474761
99KDM2B_26808549_Chip-Seq_DND41_Human1.27889181
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27712795
101KDM2B_26808549_Chip-Seq_JURKAT_Human1.26475793
102EGR1_19032775_ChIP-ChIP_M12_Human1.24876935
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24205452
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21984771
105LXR_22158963_ChIP-Seq_LIVER_Mouse1.21855509
106GATA2_19941826_ChIP-Seq_K562_Human1.21431709
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.21024607
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20482808
109PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20139919
110MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19530112
111RUNX1_27514584_Chip-Seq_MCF-7_Human1.18862262
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18394149
113ESR1_21235772_ChIP-Seq_MCF-7_Human1.18377773
114* CREB1_26743006_Chip-Seq_LNCaP_Human1.18236669
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18213004
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18121300
117SMAD_19615063_ChIP-ChIP_OVARY_Human1.17210004
118* GATA1_19941827_ChIP-Seq_MEL_Mouse1.17125350
119HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16755364
120TFEB_21752829_ChIP-Seq_HELA_Human1.14620500
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14362852
122ELF1_20517297_ChIP-Seq_JURKAT_Human1.13396296
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13135342
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12381497
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10571617
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10142288
127* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09599332
128* ATF3_27146783_Chip-Seq_COLON_Human1.08914864
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08843392
130* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08352615
131* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07596320
132LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07366218
133TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07262303
134ELK3_25401928_ChIP-Seq_HUVEC_Human1.07218160
135GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06381464
136BCOR_27268052_Chip-Seq_Bcells_Human1.06113386
137* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04481441
138CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04200859
139KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03973072
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03707970
141NCOR1_26117541_ChIP-Seq_K562_Human1.03668049
142CIITA_25753668_ChIP-Seq_RAJI_Human1.01994931
143* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01718606
144SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01523047
145BP1_19119308_ChIP-ChIP_Hs578T_Human1.01458734
146NFE2_27457419_Chip-Seq_LIVER_Mouse1.01017070
147GATA1_19941826_ChIP-Seq_K562_Human1.00502501
148TP53_22127205_ChIP-Seq_IMR90_Human0.99913994
149PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99769808
150CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99346407
151HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96934082
152* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95576347
153GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92901293
154CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92335506
155PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91777225
156PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90862422
157CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88283931
158ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88150867
159CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83226707

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.03718882
2MP0002009_preneoplasia3.48477763
3MP0003705_abnormal_hypodermis_morpholog3.33020515
4MP0005451_abnormal_body_composition3.16993168
5MP0004381_abnormal_hair_follicle2.86430188
6MP0002166_altered_tumor_susceptibility2.85284125
7MP0009840_abnormal_foam_cell2.81000896
8MP0003880_abnormal_central_pattern2.80737614
9MP0006292_abnormal_olfactory_placode2.80539141
10MP0003763_abnormal_thymus_physiology2.75267327
11MP0002139_abnormal_hepatobiliary_system2.74950605
12MP0001835_abnormal_antigen_presentation2.60057109
13MP0005174_abnormal_tail_pigmentation2.59389079
14MP0005671_abnormal_response_to2.55939023
15MP0005409_darkened_coat_color2.43602575
16MP0003172_abnormal_lysosome_physiology2.42458187
17MP0000685_abnormal_immune_system2.37212189
18MP0003436_decreased_susceptibility_to2.27453679
19MP0005387_immune_system_phenotype2.26134393
20MP0001790_abnormal_immune_system2.26134393
21MP0003136_yellow_coat_color2.25534519
22MP0001800_abnormal_humoral_immune2.24196451
23MP0008438_abnormal_cutaneous_collagen2.23446127
24MP0003868_abnormal_feces_composition2.23014537
25MP0000015_abnormal_ear_pigmentation2.21803565
26MP0002006_tumorigenesis2.21625668
27MP0009278_abnormal_bone_marrow2.20097758
28MP0005076_abnormal_cell_differentiation2.18376298
29MP0009785_altered_susceptibility_to2.14170608
30MP0005000_abnormal_immune_tolerance2.11310051
31MP0002452_abnormal_antigen_presenting1.99735898
32MP0005025_abnormal_response_to1.97960216
33MP0003566_abnormal_cell_adhesion1.96526216
34MP0002420_abnormal_adaptive_immunity1.96176235
35MP0002723_abnormal_immune_serum1.95626725
36MP0001819_abnormal_immune_cell1.94555188
37MP0003724_increased_susceptibility_to1.93550432
38MP0003091_abnormal_cell_migration1.91125639
39MP0001188_hyperpigmentation1.82561592
40MP0002419_abnormal_innate_immunity1.75630658
41MP0005075_abnormal_melanosome_morpholog1.74983988
42MP0004947_skin_inflammation1.73966206
43MP0000465_gastrointestinal_hemorrhage1.73844251
44MP0003303_peritoneal_inflammation1.69452210
45MP0003866_abnormal_defecation1.68773738
46MP0005464_abnormal_platelet_physiology1.67633625
47MP0002148_abnormal_hypersensitivity_rea1.66900316
48MP0003453_abnormal_keratinocyte_physiol1.66144928
49MP0000681_abnormal_thyroid_gland1.65396754
50MP0000858_altered_metastatic_potential1.63114276
51MP0002398_abnormal_bone_marrow1.62979035
52MP0001958_emphysema1.62422314
53MP0004233_abnormal_muscle_weight1.61806825
54MP0001849_ear_inflammation1.61750582
55MP0003656_abnormal_erythrocyte_physiolo1.60974131
56MP0003329_amyloid_beta_deposits1.55521719
57MP0000716_abnormal_immune_system1.53773938
58MP0004185_abnormal_adipocyte_glucose1.51772725
59MP0000372_irregular_coat_pigmentation1.51387322
60MP0002095_abnormal_skin_pigmentation1.43757264
61MP0008007_abnormal_cellular_replicative1.42286105
62MP0002138_abnormal_hepatobiliary_system1.41687234
63MP0003300_gastrointestinal_ulcer1.41156960
64MP0004858_abnormal_nervous_system1.39647374
65MP0005670_abnormal_white_adipose1.39277134
66MP0010155_abnormal_intestine_physiology1.31257640
67MP0009333_abnormal_splenocyte_physiolog1.30709437
68MP0001845_abnormal_inflammatory_respons1.28945814
69MP0004808_abnormal_hematopoietic_stem1.27922646
70MP0010234_abnormal_vibrissa_follicle1.27152759
71MP0000689_abnormal_spleen_morphology1.26519149
72MP0002876_abnormal_thyroid_physiology1.26090098
73MP0000751_myopathy1.24677125
74MP0002429_abnormal_blood_cell1.24583205
75MP0000490_abnormal_crypts_of1.23473048
76MP0006082_CNS_inflammation1.23171219
77MP0003828_pulmonary_edema1.22005029
78MP0000733_abnormal_muscle_development1.20983446
79MP0001545_abnormal_hematopoietic_system1.20568911
80MP0002722_abnormal_immune_system1.19351257
81MP0008469_abnormal_protein_level1.19257000
82MP0003279_aneurysm1.18694268
83MP0003690_abnormal_glial_cell1.17935108
84MP0004510_myositis1.17312069
85MP0005058_abnormal_lysosome_morphology1.17239138
86MP0005621_abnormal_cell_physiology1.15875616
87MP0000703_abnormal_thymus_morphology1.14439619
88MP0002796_impaired_skin_barrier1.14058888
89MP0000604_amyloidosis1.13437255
90MP0003448_altered_tumor_morphology1.12336509
91MP0005666_abnormal_adipose_tissue1.12145515
92MP0002177_abnormal_outer_ear1.09569792
93MP0009764_decreased_sensitivity_to1.07081954
94MP0005375_adipose_tissue_phenotype1.06643677
95MP0005084_abnormal_gallbladder_morpholo1.06106427
96MP0002998_abnormal_bone_remodeling1.05424640
97MP0002060_abnormal_skin_morphology1.04311467
98MP0000003_abnormal_adipose_tissue1.04279440
99MP0008260_abnormal_autophagy1.03175606
100MP0005023_abnormal_wound_healing1.01753373
101MP0000767_abnormal_smooth_muscle1.01113324
102MP0003075_altered_response_to1.00149954
103MP0000678_abnormal_parathyroid_gland0.99913055
104MP0003943_abnormal_hepatobiliary_system0.99741509
105MP0003221_abnormal_cardiomyocyte_apopto0.97931448
106MP0000371_diluted_coat_color0.97508202
107MP0005257_abnormal_intraocular_pressure0.95297968
108MP0002405_respiratory_system_inflammati0.95177726
109MP0004264_abnormal_extraembryonic_tissu0.92450868
110MP0001853_heart_inflammation0.92357151
111MP0005501_abnormal_skin_physiology0.91814080
112MP0003183_abnormal_peptide_metabolism0.91569683
113MP0001944_abnormal_pancreas_morphology0.90895836
114MP0000759_abnormal_skeletal_muscle0.90840145
115MP0003252_abnormal_bile_duct0.90748075
116MP0008874_decreased_physiological_sensi0.90644574
117MP0002877_abnormal_melanocyte_morpholog0.90298836
118MP0003011_delayed_dark_adaptation0.89012540
119MP0001533_abnormal_skeleton_physiology0.88343311
120MP0002396_abnormal_hematopoietic_system0.87504413
121MP0001851_eye_inflammation0.85818087
122MP0000747_muscle_weakness0.85644310
123MP0005360_urolithiasis0.84464819
124MP0005408_hypopigmentation0.83321603
125MP0002693_abnormal_pancreas_physiology0.82843600
126MP0009931_abnormal_skin_appearance0.82830103
127MP0005390_skeleton_phenotype0.82741870
128MP0003191_abnormal_cellular_cholesterol0.81831768
129MP0008961_abnormal_basal_metabolism0.79755395
130MP0001765_abnormal_ion_homeostasis0.79077695
131MP0005636_abnormal_mineral_homeostasis0.78097671
132MP0002638_abnormal_pupillary_reflex0.77071503
133MP0000343_altered_response_to0.76943631
134MP0002928_abnormal_bile_duct0.76567082
135MP0002933_joint_inflammation0.76317141
136MP0003634_abnormal_glial_cell0.76037361
137MP0003795_abnormal_bone_structure0.75969881
138MP0001873_stomach_inflammation0.75306134
139MP0005166_decreased_susceptibility_to0.74788020
140MP0000609_abnormal_liver_physiology0.74313767
141MP0002075_abnormal_coat/hair_pigmentati0.73110191
142MP0009763_increased_sensitivity_to0.70723573
143MP0006054_spinal_hemorrhage0.68683304
144MP0005365_abnormal_bile_salt0.68011755
145MP0010329_abnormal_lipoprotein_level0.66615897
146MP0001186_pigmentation_phenotype0.66040913
147MP0001348_abnormal_lacrimal_gland0.65437019
148MP0005085_abnormal_gallbladder_physiolo0.64988914
149MP0005248_abnormal_Harderian_gland0.64595612
150MP0005397_hematopoietic_system_phenotyp0.64426459

Predicted human phenotypes

RankGene SetZ-score
1Pseudobulbar signs (HP:0002200)5.23240911
2Decreased circulating renin level (HP:0003351)4.64857644
3Hyperactive renin-angiotensin system (HP:0000841)4.49165478
4Abnormal hemoglobin (HP:0011902)4.28197600
5Reduced antithrombin III activity (HP:0001976)3.97899947
6Abnormality of renin-angiotensin system (HP:0000847)3.92946512
7Glomerulonephritis (HP:0000099)3.88151897
8Hyponatremia (HP:0002902)3.78742448
9Amelogenesis imperfecta (HP:0000705)3.49062795
10Stomatitis (HP:0010280)3.47859407
11Meningitis (HP:0001287)3.47512482
12Vertebral compression fractures (HP:0002953)3.45793315
13Elevated erythrocyte sedimentation rate (HP:0003565)3.38809127
14Cone-rod dystrophy (HP:0000548)3.36815064
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.33937153
16Vacuolated lymphocytes (HP:0001922)3.26451638
17Type I transferrin isoform profile (HP:0003642)3.21939763
18Metabolic alkalosis (HP:0200114)3.19987790
19Agammaglobulinemia (HP:0004432)3.12107496
20Abnormality of chloride homeostasis (HP:0011422)3.05083140
21Abnormality of dental color (HP:0011073)3.00406891
22Nonprogressive disorder (HP:0003680)3.00044424
23Chronic mucocutaneous candidiasis (HP:0002728)2.99616986
24Recurrent cutaneous fungal infections (HP:0011370)2.99616986
25Intellectual disability, progressive (HP:0006887)2.98290340
26Abnormality of sodium homeostasis (HP:0010931)2.93167770
27Joint hemorrhage (HP:0005261)2.91457474
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.91373589
29Spontaneous hematomas (HP:0007420)2.90286265
30Dysostosis multiplex (HP:0000943)2.84600267
31Hyperacusis (HP:0010780)2.84242739
32Obstructive sleep apnea (HP:0002870)2.83724703
33Broad face (HP:0000283)2.76743283
34Thyroid-stimulating hormone excess (HP:0002925)2.76434921
35Microcytic anemia (HP:0001935)2.73780041
36Distal lower limb muscle weakness (HP:0009053)2.73763437
37Protrusio acetabuli (HP:0003179)2.73065594
38Increased connective tissue (HP:0009025)2.68670771
39Alkalosis (HP:0001948)2.66540935
40Premature rupture of membranes (HP:0001788)2.65938141
41Mediastinal lymphadenopathy (HP:0100721)2.65473259
42Recurrent fungal infections (HP:0002841)2.63795761
43Distal lower limb amyotrophy (HP:0008944)2.62662932
44Hyperglycinemia (HP:0002154)2.62594737
45Abnormality of T cell number (HP:0011839)2.60605841
46Cervical subluxation (HP:0003308)2.58001137
47Gastrointestinal infarctions (HP:0005244)2.55191377
48T lymphocytopenia (HP:0005403)2.53151988
49Eczematoid dermatitis (HP:0000976)2.51631136
50Obstructive lung disease (HP:0006536)2.51507371
51Chronic obstructive pulmonary disease (HP:0006510)2.51507371
52Lower limb hyperreflexia (HP:0002395)2.48717702
53Recurrent abscess formation (HP:0002722)2.47710407
54Thoracic kyphosis (HP:0002942)2.45755283
55Upper limb amyotrophy (HP:0009129)2.45290659
56Distal upper limb amyotrophy (HP:0007149)2.45290659
57Loss of speech (HP:0002371)2.45155888
58Cerebral aneurysm (HP:0004944)2.42483516
59Epistaxis (HP:0000421)2.41467909
60Prolonged partial thromboplastin time (HP:0003645)2.40997555
61Hypothermia (HP:0002045)2.40171977
62Abnormality of liposaccharide metabolism (HP:0010968)2.39692801
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.39692801
64Abnormality of glycolipid metabolism (HP:0010969)2.39692801
65Abnormality of T cells (HP:0002843)2.36617868
66Centrally nucleated skeletal muscle fibers (HP:0003687)2.35597458
67Gingival bleeding (HP:0000225)2.34684006
68Abnormality of macrophages (HP:0004311)2.33594889
69Myositis (HP:0100614)2.33536216
70Neuronal loss in central nervous system (HP:0002529)2.33090631
71Nephritis (HP:0000123)2.32905522
72Hemoptysis (HP:0002105)2.32576075
73Recurrent skin infections (HP:0001581)2.31547354
74Recurrent viral infections (HP:0004429)2.31439269
75Macrocytic anemia (HP:0001972)2.25688404
76Late onset (HP:0003584)2.24833516
77Mucopolysacchariduria (HP:0008155)2.24406967
78Urinary glycosaminoglycan excretion (HP:0003541)2.24406967
79J-shaped sella turcica (HP:0002680)2.24313051
80Panhypogammaglobulinemia (HP:0003139)2.23674376
81Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22897938
82Abnormality of polysaccharide metabolism (HP:0011012)2.22897938
83Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22897938
84Autoimmune thrombocytopenia (HP:0001973)2.22666058
85Recurrent bacterial skin infections (HP:0005406)2.21862975
86Vasculitis (HP:0002633)2.21151799
87Abnormality of T cell physiology (HP:0011840)2.19989855
88Increased variability in muscle fiber diameter (HP:0003557)2.19412172
89Thin bony cortex (HP:0002753)2.18955952
90Achilles tendon contracture (HP:0001771)2.17137279
91Abnormality of monocarboxylic acid metabolism (HP:0010996)2.16973932
92IgG deficiency (HP:0004315)2.15344963
93Increased IgM level (HP:0003496)2.13917406
94Recurrent gram-negative bacterial infections (HP:0005420)2.13818177
95Colitis (HP:0002583)2.13723499
96Hyperglycinuria (HP:0003108)2.13699390
97Neonatal onset (HP:0003623)2.13591709
98Spinal cord lesions (HP:0100561)2.13237004
99Syringomyelia (HP:0003396)2.13237004
100Inflammation of the large intestine (HP:0002037)2.13152295
101Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12492338
102Abnormal protein N-linked glycosylation (HP:0012347)2.12492338
103Abnormal protein glycosylation (HP:0012346)2.12492338
104Abnormal glycosylation (HP:0012345)2.12492338
105Hyperaldosteronism (HP:0000859)2.12242615
106IgM deficiency (HP:0002850)2.11134872
107Excessive salivation (HP:0003781)2.11003320
108Drooling (HP:0002307)2.11003320
109Encephalitis (HP:0002383)2.09747638
110Testicular atrophy (HP:0000029)2.08571827
111Dilatation of the ascending aorta (HP:0005111)2.07727029
112Abnormal gallbladder physiology (HP:0012438)2.07627683
113Cholecystitis (HP:0001082)2.07627683
114Cellulitis (HP:0100658)2.05898515
115Abnormality of skeletal muscle fiber size (HP:0012084)2.05709401
116Cerebral inclusion bodies (HP:0100314)2.05666458
117Fatigue (HP:0012378)2.02819836
118Hand muscle atrophy (HP:0009130)2.02040305
119Gastrointestinal stroma tumor (HP:0100723)2.01711029
120Abnormality of the distal phalanges of the toes (HP:0010182)2.01433347
121Spinal rigidity (HP:0003306)2.01398519
122Supranuclear gaze palsy (HP:0000605)2.01326576
123Abnormality of the prostate (HP:0008775)2.01138254
124Prolonged bleeding time (HP:0003010)2.00215106
125Thrombocytosis (HP:0001894)1.99621006
126Flat acetabular roof (HP:0003180)1.99305358
127Increased cerebral lipofuscin (HP:0011813)1.99233047
128Cheilitis (HP:0100825)1.99047380
129Uterine leiomyosarcoma (HP:0002891)1.97315990
130Leiomyosarcoma (HP:0100243)1.97315990
131Gastrointestinal inflammation (HP:0004386)1.97090206
132Adrenal overactivity (HP:0002717)1.94389808
133Hyperparathyroidism (HP:0000843)1.92785408
134Stridor (HP:0010307)1.92591110
135Increased IgE level (HP:0003212)1.92530708
136Abdominal distention (HP:0003270)1.92438223
137Interstitial pulmonary disease (HP:0006530)1.92395616
138Eosinophilia (HP:0001880)1.91457773
139Skin rash (HP:0000988)1.91057229
140Chest pain (HP:0100749)1.91026592
141Complement deficiency (HP:0004431)1.90818981
142Basal ganglia calcification (HP:0002135)1.90818507
143Growth hormone excess (HP:0000845)1.90382153
144Reticulocytopenia (HP:0001896)1.90340042
145Biconcave vertebral bodies (HP:0004586)1.89739176
146Neurofibrillary tangles (HP:0002185)1.89498511
147Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.89392026
148Axonal loss (HP:0003447)1.88934281
149Hypercortisolism (HP:0001578)1.88678980
150Hypertensive crisis (HP:0100735)1.88161736
151Aneurysm (HP:0002617)1.88059207
152Polydipsia (HP:0001959)1.87946759
153Abnormal drinking behavior (HP:0030082)1.87946759
154Ulnar bowing (HP:0003031)1.87067682
155Slow saccadic eye movements (HP:0000514)1.86614894
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.85856913
157Osteolytic defects of the hand bones (HP:0009699)1.85856913
158Hemorrhage of the eye (HP:0011885)1.85501561
159Abnormality of the Achilles tendon (HP:0005109)1.85406231
160Mitral regurgitation (HP:0001653)1.81689900
161Seborrheic dermatitis (HP:0001051)1.81044277
162Segmental peripheral demyelination/remyelination (HP:0003481)1.80507453
163Insomnia (HP:0100785)1.80283367
164Emphysema (HP:0002097)1.79472807
165Exercise-induced myalgia (HP:0003738)1.78089412
166Sparse lateral eyebrow (HP:0005338)1.77424246
167Reticulocytosis (HP:0001923)1.76438028
168Foot dorsiflexor weakness (HP:0009027)1.75465907
169Abnormality of the thoracic spine (HP:0100711)1.73919797
170Lower limb amyotrophy (HP:0007210)1.72481416
171Gingivitis (HP:0000230)1.72268889
172Asymmetric septal hypertrophy (HP:0001670)1.72177672
173Mildly elevated creatine phosphokinase (HP:0008180)1.71084136
174Long toe (HP:0010511)1.70254868
175Spondylolisthesis (HP:0003302)1.69907291
176Peripheral hypomyelination (HP:0007182)1.69069638
177Distal sensory impairment (HP:0002936)1.66197488
178Hammertoe (HP:0001765)1.64842880
179Blue sclerae (HP:0000592)1.64170536
180Ragged-red muscle fibers (HP:0003200)1.63971726
181Wormian bones (HP:0002645)1.63925800
182Long palpebral fissure (HP:0000637)1.63154803
183Gastrointestinal dysmotility (HP:0002579)1.62282051
184Bone pain (HP:0002653)1.62159340
185Short nail (HP:0001799)1.61972105
186Generalized amyotrophy (HP:0003700)1.61012738
187Disproportionate tall stature (HP:0001519)1.60784313
188Amyloidosis (HP:0011034)1.59957148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NLK3.74226824
2TLK13.48962138
3CLK13.41109467
4TSSK63.38358887
5IRAK33.05736303
6IRAK42.94865803
7TXK2.73351956
8CASK2.63599328
9MAP4K12.61792944
10TNIK2.46904865
11SMG12.46876416
12NME22.32618974
13HIPK22.29103944
14ICK2.20189173
15TGFBR22.16720401
16GRK62.13731244
17MAPK152.07249362
18EIF2AK31.98404754
19CDK121.90580291
20RIPK11.90172822
21STK111.87780510
22MAP3K141.82817417
23TAOK31.81366108
24SIK31.71375152
25IKBKE1.70650011
26EEF2K1.69432548
27TAOK21.68742226
28TAOK11.67625578
29TESK11.65532268
30TEC1.65481263
31MAP3K31.63292938
32IRAK11.61376574
33BTK1.58901639
34JAK31.53658671
35IRAK21.52124233
36PKN21.51084823
37ZAP701.48739996
38YES11.42859324
39TBK11.42089791
40KSR21.39910331
41CSK1.38971910
42TTN1.36048297
43MKNK21.32227954
44PIM11.29035718
45MST41.28977049
46PDGFRA1.27920695
47NEK91.26098217
48EPHA21.25670357
49SCYL21.24299347
50IKBKB1.23670986
51EIF2AK11.23335788
52MARK21.22078040
53EPHA31.20970314
54KIT1.19614486
55UHMK11.17436098
56MUSK1.16916719
57MAP3K111.16867613
58MAP3K61.10848961
59DYRK1B1.09198535
60PAK41.09187348
61FGR1.07594472
62FGFR31.07034334
63JAK11.05877938
64FES1.04154148
65FGFR41.02331858
66MTOR0.97059306
67PDPK10.94240373
68TYK20.91989440
69TNK20.91734947
70LMTK20.91113467
71ITK0.90749392
72JAK20.90502643
73HCK0.89675585
74PIM20.89016796
75LCK0.87710456
76CDC42BPA0.84774155
77SYK0.84693679
78FLT30.84609902
79MAP3K100.84504094
80RET0.82098003
81ARAF0.81110994
82SRPK10.80938121
83STK100.80574494
84INSRR0.80400712
85SGK20.80059323
86TRIB30.79613026
87SIK20.77442477
88BLK0.77352624
89RPS6KA20.76285204
90EIF2AK20.74944575
91PIK3CG0.74082139
92LYN0.73973654
93MAP2K20.73538668
94MST1R0.69849443
95LRRK20.67390442
96PRKD30.66663466
97PTK20.64918322
98PDK10.62246635
99EPHB10.61589855
100DDR20.61527310
101GRK70.59892669
102CDK60.58877751
103BMX0.58778982
104RPS6KL10.58523976
105RPS6KC10.58523976
106NTRK10.56797711
107MAPK120.56568745
108RIPK40.55854862
109RAF10.55317805
110SGK30.55069336
111* PRKD20.54773542
112RPS6KA60.53482485
113CSF1R0.52694663
114TESK20.50890060
115MAPKAPK20.50506474
116PRKG20.50254948
117CHUK0.49621743
118ERN10.49361185
119PRPF4B0.47912956
120CAMKK20.47793988
121NEK60.47792446
122MAPKAPK30.47735849
123MAP3K70.47014314
124ABL10.46527193
125CAMKK10.44431374
126CSNK1G10.43462963
127VRK10.43162124
128SIK10.42557994
129MAP3K80.41983652
130PAK60.41286337
131MAPK70.41121396
132CDK90.39507149
133BCKDK0.38163593
134* PRKD10.37344792
135RPS6KB20.37288554
136MAP2K10.37161826
137MAP3K20.37161033
138MAPK110.36808508
139PDGFRB0.36753551
140MAP3K50.36160171
141MAP3K10.35007491
142MAP2K30.34716295
143PRKCH0.34577609
144MAP3K130.32826932
145FRK0.30556875
146BMPR20.29633671
147PTK60.28525314
148CDK40.28292413
149MAPK40.27874950
150RPS6KA40.27758583
151MKNK10.26439563
152CAMK40.24632303
153CAMK2B0.23839963

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052163.01573147
2Primary immunodeficiency_Homo sapiens_hsa053402.98917405
3Antigen processing and presentation_Homo sapiens_hsa046122.90410343
4Measles_Homo sapiens_hsa051622.55234068
5Graft-versus-host disease_Homo sapiens_hsa053322.46453378
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.43614333
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.43579480
8Acute myeloid leukemia_Homo sapiens_hsa052212.37895979
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.25885411
10Other glycan degradation_Homo sapiens_hsa005112.20072287
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.15562908
12Ribosome_Homo sapiens_hsa030101.98610093
13B cell receptor signaling pathway_Homo sapiens_hsa046621.83695003
14Non-small cell lung cancer_Homo sapiens_hsa052231.78243834
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.76802665
16Leishmaniasis_Homo sapiens_hsa051401.72773392
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66756700
18Staphylococcus aureus infection_Homo sapiens_hsa051501.65870957
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61100208
20Protein export_Homo sapiens_hsa030601.57215648
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56979723
22Osteoclast differentiation_Homo sapiens_hsa043801.53347495
23T cell receptor signaling pathway_Homo sapiens_hsa046601.53165575
24Pancreatic cancer_Homo sapiens_hsa052121.52206387
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.49438930
26VEGF signaling pathway_Homo sapiens_hsa043701.48756456
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46844630
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38773964
29Notch signaling pathway_Homo sapiens_hsa043301.38426736
30Bladder cancer_Homo sapiens_hsa052191.31331511
31Hematopoietic cell lineage_Homo sapiens_hsa046401.30688705
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30652564
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.29660710
34Endometrial cancer_Homo sapiens_hsa052131.29600654
35One carbon pool by folate_Homo sapiens_hsa006701.28257710
36mTOR signaling pathway_Homo sapiens_hsa041501.26947958
37Pentose phosphate pathway_Homo sapiens_hsa000301.26769236
38Fructose and mannose metabolism_Homo sapiens_hsa000511.23023514
39Prostate cancer_Homo sapiens_hsa052151.23016024
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22576562
41Sulfur relay system_Homo sapiens_hsa041221.20524186
42Shigellosis_Homo sapiens_hsa051311.19744837
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19349482
44Renal cell carcinoma_Homo sapiens_hsa052111.19059596
45Herpes simplex infection_Homo sapiens_hsa051681.18609838
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.17947831
47Complement and coagulation cascades_Homo sapiens_hsa046101.16776703
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14109094
49Influenza A_Homo sapiens_hsa051641.12755131
50Glioma_Homo sapiens_hsa052141.12014345
51Colorectal cancer_Homo sapiens_hsa052101.08857111
52Allograft rejection_Homo sapiens_hsa053301.08690875
53ErbB signaling pathway_Homo sapiens_hsa040121.08357070
54Insulin signaling pathway_Homo sapiens_hsa049101.08218224
55Endocytosis_Homo sapiens_hsa041441.07630248
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07577156
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06816294
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06743265
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06529124
60Toxoplasmosis_Homo sapiens_hsa051451.06130524
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05535578
62Leukocyte transendothelial migration_Homo sapiens_hsa046701.05409676
63Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03702171
64Adipocytokine signaling pathway_Homo sapiens_hsa049201.00610028
65Pertussis_Homo sapiens_hsa051330.99769589
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.99177584
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99118135
68Vibrio cholerae infection_Homo sapiens_hsa051100.98257725
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.97628038
70Ether lipid metabolism_Homo sapiens_hsa005650.95785266
71Lysosome_Homo sapiens_hsa041420.94227732
72GnRH signaling pathway_Homo sapiens_hsa049120.91492763
73* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90803803
74Chemokine signaling pathway_Homo sapiens_hsa040620.89467952
75Estrogen signaling pathway_Homo sapiens_hsa049150.89133543
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.89060599
77Legionellosis_Homo sapiens_hsa051340.88299391
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87605473
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85936200
80AMPK signaling pathway_Homo sapiens_hsa041520.85691159
81Tuberculosis_Homo sapiens_hsa051520.84456693
82* Inositol phosphate metabolism_Homo sapiens_hsa005620.84096791
83Hepatitis B_Homo sapiens_hsa051610.83897457
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83399533
85Focal adhesion_Homo sapiens_hsa045100.83101869
86Insulin resistance_Homo sapiens_hsa049310.82808955
87Amoebiasis_Homo sapiens_hsa051460.82520204
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80611276
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79762413
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.79373253
91Malaria_Homo sapiens_hsa051440.77906941
92Viral carcinogenesis_Homo sapiens_hsa052030.77345888
93HTLV-I infection_Homo sapiens_hsa051660.76875082
94Proteoglycans in cancer_Homo sapiens_hsa052050.76683600
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75802158
96Apoptosis_Homo sapiens_hsa042100.74642649
97Small cell lung cancer_Homo sapiens_hsa052220.74371725
98Phagosome_Homo sapiens_hsa041450.71967814
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71904663
100ABC transporters_Homo sapiens_hsa020100.71679351
101Chronic myeloid leukemia_Homo sapiens_hsa052200.71223749
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70861362
103DNA replication_Homo sapiens_hsa030300.70728957
104Platelet activation_Homo sapiens_hsa046110.70555866
105Adherens junction_Homo sapiens_hsa045200.70527531
106Epstein-Barr virus infection_Homo sapiens_hsa051690.70021299
107Hepatitis C_Homo sapiens_hsa051600.67330921
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67320597
109Galactose metabolism_Homo sapiens_hsa000520.66995543
110HIF-1 signaling pathway_Homo sapiens_hsa040660.66638966
111TNF signaling pathway_Homo sapiens_hsa046680.66496691
112Vitamin digestion and absorption_Homo sapiens_hsa049770.66231967
113Prion diseases_Homo sapiens_hsa050200.63997350
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63858490
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61953675
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59956598
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58248522
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57736954
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56775129
120Folate biosynthesis_Homo sapiens_hsa007900.56439703
121Arginine biosynthesis_Homo sapiens_hsa002200.56106855
122N-Glycan biosynthesis_Homo sapiens_hsa005100.55575106
123Biosynthesis of amino acids_Homo sapiens_hsa012300.54608454
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54199481
125MicroRNAs in cancer_Homo sapiens_hsa052060.53381720
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53262779
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52697419
128Nitrogen metabolism_Homo sapiens_hsa009100.50552922
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48781697
130Autoimmune thyroid disease_Homo sapiens_hsa053200.47582469
131Retinol metabolism_Homo sapiens_hsa008300.46409665
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.45261135
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45210860
134Spliceosome_Homo sapiens_hsa030400.44179049
135Basal cell carcinoma_Homo sapiens_hsa052170.43050506
136Prolactin signaling pathway_Homo sapiens_hsa049170.42810422
137Systemic lupus erythematosus_Homo sapiens_hsa053220.41291353
138Type I diabetes mellitus_Homo sapiens_hsa049400.40792657
139Lysine degradation_Homo sapiens_hsa003100.40641707
140Starch and sucrose metabolism_Homo sapiens_hsa005000.38133723
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.38033358
142Caffeine metabolism_Homo sapiens_hsa002320.37765314
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37151781
144Sphingolipid metabolism_Homo sapiens_hsa006000.36199127
145FoxO signaling pathway_Homo sapiens_hsa040680.35813054
146Viral myocarditis_Homo sapiens_hsa054160.33662402
147Salmonella infection_Homo sapiens_hsa051320.32604833
148Choline metabolism in cancer_Homo sapiens_hsa052310.31212959
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.30184795
150Tryptophan metabolism_Homo sapiens_hsa003800.30074673

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