PI4KA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.81158736
2locomotory exploration behavior (GO:0035641)5.53685077
3synaptic vesicle maturation (GO:0016188)5.44451060
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.25247666
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.98087642
6vocalization behavior (GO:0071625)4.73905418
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.67310976
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.64952068
9synaptic vesicle exocytosis (GO:0016079)4.58052986
10glutamate secretion (GO:0014047)4.52177147
11regulation of glutamate receptor signaling pathway (GO:1900449)4.49981478
12cerebellar granule cell differentiation (GO:0021707)4.43139149
13regulation of synaptic vesicle exocytosis (GO:2000300)4.42868909
14cytoskeletal anchoring at plasma membrane (GO:0007016)4.28890150
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.21218757
16negative regulation of erythrocyte differentiation (GO:0045647)4.16134666
17amino acid import (GO:0043090)4.07316582
18exploration behavior (GO:0035640)4.01796500
19sodium ion export (GO:0071436)4.01052704
20regulation of synaptic vesicle transport (GO:1902803)4.00384651
21neurotransmitter secretion (GO:0007269)3.99017681
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.95734614
23cellular potassium ion homeostasis (GO:0030007)3.94139888
24regulation of neuronal synaptic plasticity (GO:0048168)3.93000445
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.89467494
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.84363596
27protein localization to synapse (GO:0035418)3.82633381
28regulation of synapse structural plasticity (GO:0051823)3.82603122
29gamma-aminobutyric acid transport (GO:0015812)3.82597231
30proline transport (GO:0015824)3.80997184
31layer formation in cerebral cortex (GO:0021819)3.74073618
32synaptic transmission, glutamatergic (GO:0035249)3.70497901
33neuronal action potential propagation (GO:0019227)3.68522135
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.62351660
35glutamate receptor signaling pathway (GO:0007215)3.60860434
36negative regulation of dendrite morphogenesis (GO:0050774)3.59842377
37cerebellar Purkinje cell differentiation (GO:0021702)3.59495793
38activation of protein kinase A activity (GO:0034199)3.58422207
39long-term memory (GO:0007616)3.56979533
40neurotransmitter-gated ion channel clustering (GO:0072578)3.56929368
41regulation of ARF protein signal transduction (GO:0032012)3.51807655
42positive regulation of Rap GTPase activity (GO:0032854)3.50372212
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.47057074
44neuron-neuron synaptic transmission (GO:0007270)3.44526658
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.42624779
46dendritic spine morphogenesis (GO:0060997)3.40980751
47positive regulation of membrane potential (GO:0045838)3.40186393
48neuron cell-cell adhesion (GO:0007158)3.35361270
49cell communication by electrical coupling (GO:0010644)3.31944715
50regulation of postsynaptic membrane potential (GO:0060078)3.30016622
51synaptic vesicle endocytosis (GO:0048488)3.29607623
52neuromuscular process controlling balance (GO:0050885)3.28103880
53positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.25144253
54regulation of synaptic plasticity (GO:0048167)3.21145095
55regulation of dendritic spine morphogenesis (GO:0061001)3.19085291
56neurotransmitter transport (GO:0006836)3.17865245
57regulation of synapse maturation (GO:0090128)3.14969902
58glycine transport (GO:0015816)3.14133225
59membrane depolarization during action potential (GO:0086010)3.13796734
60G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.11647281
61regulation of Rap GTPase activity (GO:0032317)3.10508758
62long-term synaptic potentiation (GO:0060291)3.10467398
63dendrite morphogenesis (GO:0048813)3.10338297
64vesicle transport along microtubule (GO:0047496)3.09291955
65regulation of ARF GTPase activity (GO:0032312)3.09034003
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.08340919
67positive regulation of synapse maturation (GO:0090129)3.08219117
68L-amino acid import (GO:0043092)3.06483814
69neuromuscular process controlling posture (GO:0050884)3.05344460
70signal complex assembly (GO:0007172)3.05177367
71regulation of neurotransmitter secretion (GO:0046928)3.03542357
72prepulse inhibition (GO:0060134)3.03146846
73regulation of synaptic transmission, glutamatergic (GO:0051966)3.01149087
74mannose metabolic process (GO:0006013)2.98526978
75regulation of early endosome to late endosome transport (GO:2000641)2.96170820
76potassium ion import (GO:0010107)2.93848612
77positive regulation of synaptic transmission, GABAergic (GO:0032230)2.92341375
78establishment of nucleus localization (GO:0040023)2.90476573
79nerve growth factor signaling pathway (GO:0038180)2.89829989
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.89764333
81regulation of neurotransmitter levels (GO:0001505)2.89210039
82chemosensory behavior (GO:0007635)2.89095314
83negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88881303
84regulation of clathrin-mediated endocytosis (GO:2000369)2.88696187
85membrane depolarization (GO:0051899)2.88104806
86membrane hyperpolarization (GO:0060081)2.87822855
87response to auditory stimulus (GO:0010996)2.86785022
88transmission of nerve impulse (GO:0019226)2.84445013
89positive regulation of neurotransmitter secretion (GO:0001956)2.83259468
90cellular sodium ion homeostasis (GO:0006883)2.82427612
91gamma-aminobutyric acid signaling pathway (GO:0007214)2.80223710
92neuron recognition (GO:0008038)2.79931034
93positive regulation of protein dephosphorylation (GO:0035307)2.78596483
94regulation of neurotransmitter transport (GO:0051588)2.77551416
95cell differentiation in hindbrain (GO:0021533)2.75444869
96regulation of NFAT protein import into nucleus (GO:0051532)2.74768395
97positive regulation of synaptic transmission (GO:0050806)2.72441389
98positive regulation of dendritic spine development (GO:0060999)2.70625768
99regulation of voltage-gated calcium channel activity (GO:1901385)2.70600826
100striatum development (GO:0021756)2.70460540
101auditory behavior (GO:0031223)2.70383952
102alanine transport (GO:0032328)2.69948517
103regulation of vesicle fusion (GO:0031338)2.69355453
104neuromuscular process (GO:0050905)2.68972782
105innervation (GO:0060384)2.68786906
106negative regulation of synaptic transmission, GABAergic (GO:0032229)2.68012501
107positive regulation of neurotransmitter transport (GO:0051590)2.67041251
108neuronal ion channel clustering (GO:0045161)2.66966463
109potassium ion homeostasis (GO:0055075)2.66916266
110axonal fasciculation (GO:0007413)2.66549286
111positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.66071997
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.65893049
113social behavior (GO:0035176)2.65145516
114intraspecies interaction between organisms (GO:0051703)2.65145516
115mating behavior (GO:0007617)2.64916090
116response to histamine (GO:0034776)2.63682830
117presynaptic membrane assembly (GO:0097105)2.63220251
118organelle transport along microtubule (GO:0072384)2.62906727
119regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.62858969
120regulation of dendritic spine development (GO:0060998)2.62802335
121peptidyl-threonine phosphorylation (GO:0018107)2.54877517
122positive regulation of dendritic spine morphogenesis (GO:0061003)2.53612835
123cerebellar Purkinje cell layer development (GO:0021680)2.52582287
124peptidyl-tyrosine autophosphorylation (GO:0038083)2.51099827
125cell migration in hindbrain (GO:0021535)2.51030223
126cellular response to monoamine stimulus (GO:0071868)2.48108760
127cellular response to catecholamine stimulus (GO:0071870)2.48108760
128regulation of beta-amyloid formation (GO:1902003)2.46777175
129dopamine receptor signaling pathway (GO:0007212)2.46745102
130vesicle docking involved in exocytosis (GO:0006904)2.46650695
131visual learning (GO:0008542)2.46024333
132regulation of histone H3-K27 methylation (GO:0061085)2.44980267
133regulation of exocytosis (GO:0017157)2.44530045
134protein localization to endosome (GO:0036010)2.39721207
135regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.39426454
136axon ensheathment in central nervous system (GO:0032291)2.39240504
137central nervous system myelination (GO:0022010)2.39240504
138positive regulation of fibroblast migration (GO:0010763)2.39180117
139regulation of synaptic transmission (GO:0050804)2.38986304
140dendritic spine organization (GO:0097061)2.36656688
141retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.36281474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.50993521
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.45840831
3GBX2_23144817_ChIP-Seq_PC3_Human2.97234713
4DROSHA_22980978_ChIP-Seq_HELA_Human2.81567113
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.68351116
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60147377
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58327475
8LXR_22292898_ChIP-Seq_THP-1_Human2.57179850
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42454563
10REST_21632747_ChIP-Seq_MESCs_Mouse2.40885034
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38987718
12KDM2B_26808549_Chip-Seq_DND41_Human2.35858270
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.33653918
14TCF7_22412390_ChIP-Seq_EML_Mouse2.28043921
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25337389
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25337389
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24664845
18MYC_22102868_ChIP-Seq_BL_Human2.23182358
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21413798
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19473533
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.19393897
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18280929
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17855158
24VDR_21846776_ChIP-Seq_THP-1_Human2.17369048
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09457737
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05862168
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97989103
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94399649
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.93935963
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86489676
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86308516
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.85846526
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.84772218
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82302520
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.79338042
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71861052
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69830108
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.69598702
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.67915086
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.67661313
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.62922814
42RACK7_27058665_Chip-Seq_MCF-7_Human1.58486602
43SMC4_20622854_ChIP-Seq_HELA_Human1.56603484
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.55405838
45AR_21572438_ChIP-Seq_LNCaP_Human1.54280745
46SMAD4_21799915_ChIP-Seq_A2780_Human1.53520543
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53427170
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52175952
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48675487
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46391564
51CREB1_26743006_Chip-Seq_LNCaP_Human1.45075413
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41255615
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41237988
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39490965
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39213202
56KDM2B_26808549_Chip-Seq_K562_Human1.39108033
57SPI1_23127762_ChIP-Seq_K562_Human1.38391113
58VDR_24763502_ChIP-Seq_THP-1_Human1.37778634
59GATA1_19941826_ChIP-Seq_K562_Human1.37325946
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37242253
61SCL_19346495_ChIP-Seq_HPC-7_Human1.36333356
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35813466
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35420485
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35208734
65AR_19668381_ChIP-Seq_PC3_Human1.33221157
66* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32776108
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.31442692
68P68_20966046_ChIP-Seq_HELA_Human1.30849752
69* TET1_21490601_ChIP-Seq_MESCs_Mouse1.30311723
70STAT3_23295773_ChIP-Seq_U87_Human1.28249226
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27811742
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26873692
73AHR_22903824_ChIP-Seq_MCF-7_Human1.26792990
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.26506755
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26306473
76P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25858541
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25621263
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24310119
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23325232
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22624347
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.22290342
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21806952
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21266853
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21198724
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.21097026
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20787758
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19667011
88MAF_26560356_Chip-Seq_TH1_Human1.17546631
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16835194
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16672801
91CTCF_27219007_Chip-Seq_Bcells_Human1.15621133
92TCF4_23295773_ChIP-Seq_U87_Human1.15030370
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12806077
94ZNF274_21170338_ChIP-Seq_K562_Hela1.12173131
95OCT4_19829295_ChIP-Seq_ESCs_Human1.12017192
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11654451
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11445895
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.11310325
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.10401639
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09785307
101* AR_25329375_ChIP-Seq_VCAP_Human1.08218787
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08194604
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07838033
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07787159
105DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07613787
106TET1_21451524_ChIP-Seq_MESCs_Mouse1.06951696
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06873156
108RXR_22108803_ChIP-Seq_LS180_Human1.05914118
109CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05373249
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05217255
111RUNX1_22412390_ChIP-Seq_EML_Mouse1.04920040
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04754593
113TP53_16413492_ChIP-PET_HCT116_Human1.04749747
114TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04175840
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03738215
116MAF_26560356_Chip-Seq_TH2_Human1.03203500
117GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.03020851
118EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02779548
119UTX_26944678_Chip-Seq_JUKART_Human1.02738413
120STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02650949
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02555187
122CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02089108
123* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01457113
124KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01333348
125RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01090525
126RUNX1_27514584_Chip-Seq_MCF-7_Human1.00947709
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99231992
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.98620587
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98534192
130* NCOR1_26117541_ChIP-Seq_K562_Human0.97930934
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.97852356
132FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96897029
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96854608
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.96712578
135P300_19829295_ChIP-Seq_ESCs_Human0.96450795
136RING1B_27294783_Chip-Seq_NPCs_Mouse0.96118577
137MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95327456
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.95236891
139PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93901796
140SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93863707
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93687497
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92209349
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91602520
144TAF15_26573619_Chip-Seq_HEK293_Human0.90440869
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89881879
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89396313
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88633263
148TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88266574
149POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88266574
150RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87966388
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.86308352
152EP300_21415370_ChIP-Seq_HL-1_Mouse0.84363842
153SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83953972
154KDM2B_26808549_Chip-Seq_JURKAT_Human0.83787478
155BCAT_22108803_ChIP-Seq_LS180_Human0.82980009
156BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82105525
157RUNX2_22187159_ChIP-Seq_PCA_Human0.81886534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.74448832
2MP0003635_abnormal_synaptic_transmissio4.07503624
3MP0003880_abnormal_central_pattern3.83810688
4MP0004270_analgesia3.51580565
5MP0009745_abnormal_behavioral_response3.28491434
6MP0002063_abnormal_learning/memory/cond3.26170299
7MP0002064_seizures3.11566440
8MP0009046_muscle_twitch3.08161702
9MP0005423_abnormal_somatic_nervous2.88755853
10MP0002822_catalepsy2.88050200
11MP0009780_abnormal_chondrocyte_physiolo2.66326658
12MP0002572_abnormal_emotion/affect_behav2.64975037
13MP0001968_abnormal_touch/_nociception2.57873513
14MP0002272_abnormal_nervous_system2.41111569
15MP0002909_abnormal_adrenal_gland2.38571468
16MP0001486_abnormal_startle_reflex2.37427093
17MP0001501_abnormal_sleep_pattern2.36452886
18MP0000569_abnormal_digit_pigmentation2.35021458
19MP0002734_abnormal_mechanical_nocicepti2.26158368
20MP0003705_abnormal_hypodermis_morpholog2.18815789
21MP0008569_lethality_at_weaning2.12056567
22MP0004858_abnormal_nervous_system2.10669129
23MP0001348_abnormal_lacrimal_gland1.98805782
24MP0002736_abnormal_nociception_after1.93647156
25MP0003787_abnormal_imprinting1.89829149
26MP0001440_abnormal_grooming_behavior1.89516378
27MP0002067_abnormal_sensory_capabilities1.87831280
28MP0008961_abnormal_basal_metabolism1.87084623
29MP0005058_abnormal_lysosome_morphology1.81156679
30MP0005646_abnormal_pituitary_gland1.78649814
31MP0004811_abnormal_neuron_physiology1.76487041
32MP0002735_abnormal_chemical_nociception1.76038248
33MP0003329_amyloid_beta_deposits1.70652203
34MP0002733_abnormal_thermal_nociception1.67654602
35MP0005386_behavior/neurological_phenoty1.66242939
36MP0004924_abnormal_behavior1.66242939
37MP0001970_abnormal_pain_threshold1.63702620
38MP0002557_abnormal_social/conspecific_i1.62316471
39MP0003123_paternal_imprinting1.58617124
40MP0004885_abnormal_endolymph1.52530641
41MP0003633_abnormal_nervous_system1.52426936
42MP0002184_abnormal_innervation1.46438664
43MP0008260_abnormal_autophagy1.45613580
44MP0003879_abnormal_hair_cell1.44745820
45MP0003283_abnormal_digestive_organ1.43989213
46MP0005451_abnormal_body_composition1.43332777
47MP0000778_abnormal_nervous_system1.39812007
48MP0000955_abnormal_spinal_cord1.37954418
49MP0009278_abnormal_bone_marrow1.37746147
50MP0002066_abnormal_motor_capabilities/c1.33294978
51MP0005645_abnormal_hypothalamus_physiol1.30854478
52MP0001984_abnormal_olfaction1.29784307
53MP0003690_abnormal_glial_cell1.27691993
54MP0002882_abnormal_neuron_morphology1.27120551
55MP0005076_abnormal_cell_differentiation1.24051341
56MP0001502_abnormal_circadian_rhythm1.22353791
57MP0004043_abnormal_pH_regulation1.22276776
58MP0003631_nervous_system_phenotype1.20828580
59MP0000751_myopathy1.17791855
60MP0010234_abnormal_vibrissa_follicle1.17419600
61MP0004510_myositis1.16881207
62MP0003172_abnormal_lysosome_physiology1.15023514
63MP0003045_fibrosis1.13686932
64MP0003091_abnormal_cell_migration1.08265162
65MP0001177_atelectasis1.04450147
66MP0003436_decreased_susceptibility_to1.02473056
67MP0002152_abnormal_brain_morphology1.02092878
68MP0003122_maternal_imprinting1.01562960
69MP0003075_altered_response_to1.00169380
70MP0000013_abnormal_adipose_tissue1.00169156
71MP0005535_abnormal_body_temperature0.98590631
72MP0002069_abnormal_eating/drinking_beha0.98371010
73MP0002229_neurodegeneration0.98136722
74MP0004947_skin_inflammation0.96116488
75MP0008874_decreased_physiological_sensi0.92899150
76MP0004085_abnormal_heartbeat0.91439463
77MP0000604_amyloidosis0.88573202
78MP0001849_ear_inflammation0.88469143
79MP0005551_abnormal_eye_electrophysiolog0.88312513
80MP0003634_abnormal_glial_cell0.86605684
81MP0004185_abnormal_adipocyte_glucose0.86145029
82MP0010386_abnormal_urinary_bladder0.85812432
83MP0004142_abnormal_muscle_tone0.84521935
84MP0003632_abnormal_nervous_system0.83662619
85MP0004130_abnormal_muscle_cell0.83546955
86MP0008872_abnormal_physiological_respon0.82746064
87MP0006276_abnormal_autonomic_nervous0.81552138
88MP0003763_abnormal_thymus_physiology0.81262315
89MP0005167_abnormal_blood-brain_barrier0.81202760
90MP0003183_abnormal_peptide_metabolism0.80873084
91MP0002009_preneoplasia0.80501413
92MP0004145_abnormal_muscle_electrophysio0.80439991
93MP0004233_abnormal_muscle_weight0.80365175
94MP0002090_abnormal_vision0.80061803
95MP0003191_abnormal_cellular_cholesterol0.79098064
96MP0005666_abnormal_adipose_tissue0.76094589
97MP0000681_abnormal_thyroid_gland0.75415869
98MP0003303_peritoneal_inflammation0.75395436
99MP0002249_abnormal_larynx_morphology0.75084470
100MP0002837_dystrophic_cardiac_calcinosis0.74914727
101MP0001765_abnormal_ion_homeostasis0.72802645
102MP0005621_abnormal_cell_physiology0.69477198
103MP0004484_altered_response_of0.68642275
104MP0005166_decreased_susceptibility_to0.67872444
105MP0003300_gastrointestinal_ulcer0.67848465
106MP0000678_abnormal_parathyroid_gland0.66917515
107MP0000920_abnormal_myelination0.66711693
108MP0004215_abnormal_myocardial_fiber0.65268438
109MP0001299_abnormal_eye_distance/0.64975255
110MP0001851_eye_inflammation0.64687508
111MP0005623_abnormal_meninges_morphology0.63489145
112MP0000003_abnormal_adipose_tissue0.63188922
113MP0004742_abnormal_vestibular_system0.62755396
114MP0009840_abnormal_foam_cell0.62726605
115MP0001529_abnormal_vocalization0.62160068
116MP0005310_abnormal_salivary_gland0.59640617
117MP0000747_muscle_weakness0.58756834
118MP0005409_darkened_coat_color0.58518812
119MP0002089_abnormal_postnatal_growth/wei0.57987776
120MP0003566_abnormal_cell_adhesion0.57456304
121MP0002998_abnormal_bone_remodeling0.57447504
122MP0002396_abnormal_hematopoietic_system0.57440669
123MP0005397_hematopoietic_system_phenotyp0.57280733
124MP0001545_abnormal_hematopoietic_system0.57280733
125MP0003137_abnormal_impulse_conducting0.56599655
126MP0005464_abnormal_platelet_physiology0.55883440
127MP0000631_abnormal_neuroendocrine_gland0.55528630
128MP0005375_adipose_tissue_phenotype0.55413628
129MP0002877_abnormal_melanocyte_morpholog0.54874651
130MP0001943_abnormal_respiration0.53816760
131MP0010769_abnormal_survival0.53798789
132MP0001963_abnormal_hearing_physiology0.51519894
133MP0001905_abnormal_dopamine_level0.51134681
134MP0010770_preweaning_lethality0.49793929

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.36847514
2Myokymia (HP:0002411)5.56162469
3Focal seizures (HP:0007359)5.16329322
4Visual hallucinations (HP:0002367)4.47488590
5Action tremor (HP:0002345)4.02685804
6Epileptic encephalopathy (HP:0200134)4.00338006
7Febrile seizures (HP:0002373)3.83933883
8Progressive cerebellar ataxia (HP:0002073)3.61684130
9Atonic seizures (HP:0010819)3.58956402
10Absence seizures (HP:0002121)3.37888397
11Impaired vibration sensation in the lower limbs (HP:0002166)3.30665732
12Supranuclear gaze palsy (HP:0000605)3.28702076
13Generalized tonic-clonic seizures (HP:0002069)3.23617368
14Postural instability (HP:0002172)3.21085204
15Dysmetric saccades (HP:0000641)3.20396933
16Dialeptic seizures (HP:0011146)3.18134164
17Gaze-evoked nystagmus (HP:0000640)3.16997235
18Abnormality of the lower motor neuron (HP:0002366)3.13415080
19Urinary bladder sphincter dysfunction (HP:0002839)3.12136627
20Dysdiadochokinesis (HP:0002075)3.11639635
21Ankle clonus (HP:0011448)3.08764826
22Poor eye contact (HP:0000817)3.08481893
23Depression (HP:0000716)3.06531249
24Abnormal social behavior (HP:0012433)3.03501978
25Impaired social interactions (HP:0000735)3.03501978
26Impaired smooth pursuit (HP:0007772)3.01491433
27Genetic anticipation (HP:0003743)2.90491199
28Broad-based gait (HP:0002136)2.84816383
29Papilledema (HP:0001085)2.82621487
30Truncal ataxia (HP:0002078)2.82499442
31Dysmetria (HP:0001310)2.77796980
32Hemiplegia (HP:0002301)2.76232677
33Abnormality of ocular smooth pursuit (HP:0000617)2.71989779
34Peripheral hypomyelination (HP:0007182)2.71360721
35Urinary urgency (HP:0000012)2.69058906
36Abnormal eating behavior (HP:0100738)2.67151224
37Cerebral aneurysm (HP:0004944)2.58907124
38Slow saccadic eye movements (HP:0000514)2.54593292
39Macroorchidism (HP:0000053)2.51838865
40Intention tremor (HP:0002080)2.51130139
41Tetraplegia (HP:0002445)2.50468833
42Bowel incontinence (HP:0002607)2.45371698
43Bradykinesia (HP:0002067)2.40976101
44Anxiety (HP:0000739)2.40767605
45Resting tremor (HP:0002322)2.39062121
46Excessive salivation (HP:0003781)2.38283205
47Drooling (HP:0002307)2.38283205
48Hyperventilation (HP:0002883)2.36467496
49Amblyopia (HP:0000646)2.36045300
50Insidious onset (HP:0003587)2.35836404
51Termporal pattern (HP:0011008)2.35836404
52Spastic gait (HP:0002064)2.33054429
53Ventricular fibrillation (HP:0001663)2.32707196
54Truncus arteriosus (HP:0001660)2.32181677
55Abnormality of the fingertips (HP:0001211)2.29806938
56Scanning speech (HP:0002168)2.29757346
57Bundle branch block (HP:0011710)2.29618404
58Stereotypic behavior (HP:0000733)2.26479881
59Abnormal large intestine physiology (HP:0012700)2.26005460
60Status epilepticus (HP:0002133)2.25963277
61Hemiparesis (HP:0001269)2.25517938
62Apathy (HP:0000741)2.25283482
63Diplopia (HP:0000651)2.24407635
64Abnormality of binocular vision (HP:0011514)2.24407635
65Pointed chin (HP:0000307)2.23531611
66Impaired vibratory sensation (HP:0002495)2.23508737
67Hyperthyroidism (HP:0000836)2.21000597
68Torticollis (HP:0000473)2.19439745
69Insomnia (HP:0100785)2.18941345
70Neuronal loss in central nervous system (HP:0002529)2.18824404
71Hand muscle atrophy (HP:0009130)2.16178511
72Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.14826976
73Annular pancreas (HP:0001734)2.14780945
74Lower limb muscle weakness (HP:0007340)2.09451139
75Epileptiform EEG discharges (HP:0011182)2.04342463
76Increased circulating renin level (HP:0000848)2.02534241
77Cerebral inclusion bodies (HP:0100314)2.01722363
78Diminished motivation (HP:0000745)2.01075693
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00502041
80Lower limb amyotrophy (HP:0007210)1.99374005
81Akinesia (HP:0002304)1.98552061
82EEG with generalized epileptiform discharges (HP:0011198)1.98393815
83Absent speech (HP:0001344)1.98113164
84Mutism (HP:0002300)1.97343201
85Blue irides (HP:0000635)1.96705642
86Lower limb asymmetry (HP:0100559)1.96090719
87Ankyloglossia (HP:0010296)1.95330486
88Abnormality of saccadic eye movements (HP:0000570)1.94199613
89Hyperacusis (HP:0010780)1.93918756
90Focal dystonia (HP:0004373)1.91618847
91Broad face (HP:0000283)1.90267554
92Hypsarrhythmia (HP:0002521)1.90175392
93Ocular albinism (HP:0001107)1.89868311
94Spinal canal stenosis (HP:0003416)1.89567283
95Agitation (HP:0000713)1.87308156
96Decreased motor nerve conduction velocity (HP:0003431)1.84356382
97Gait ataxia (HP:0002066)1.83781921
98Progressive inability to walk (HP:0002505)1.83627653
99Onion bulb formation (HP:0003383)1.83374722
100Hypercortisolism (HP:0001578)1.83369657
101Megalencephaly (HP:0001355)1.83008373
102Neoplasm of the heart (HP:0100544)1.82492411
103Distal sensory impairment (HP:0002936)1.82066360
104Cholecystitis (HP:0001082)1.81732484
105Abnormal gallbladder physiology (HP:0012438)1.81732484
106Abnormality of the periventricular white matter (HP:0002518)1.81038185
107Abnormality of the corticospinal tract (HP:0002492)1.79874629
108Distal upper limb amyotrophy (HP:0007149)1.79625471
109Upper limb amyotrophy (HP:0009129)1.79625471
110Clonus (HP:0002169)1.78296303
111Hammertoe (HP:0001765)1.78178917
112Neurofibrillary tangles (HP:0002185)1.77715978
113Elfin facies (HP:0004428)1.77310515
114Distal lower limb amyotrophy (HP:0008944)1.76608375
115Cellulitis (HP:0100658)1.74775163
116Dysostosis multiplex (HP:0000943)1.72821112
117Rapidly progressive (HP:0003678)1.72487764
118Deep palmar crease (HP:0006191)1.71330453
119Aplasia involving bones of the upper limbs (HP:0009823)1.70813994
120Aplasia of the phalanges of the hand (HP:0009802)1.70813994
121Aplasia involving bones of the extremities (HP:0009825)1.70813994
122Abnormal EKG (HP:0003115)1.70066588
123Rigidity (HP:0002063)1.69882095
124Obstructive sleep apnea (HP:0002870)1.69718845
125Personality changes (HP:0000751)1.68333254
126Craniofacial dystonia (HP:0012179)1.68249619
127Incomplete penetrance (HP:0003829)1.68085276
128Prolonged QT interval (HP:0001657)1.67652317
129Amyotrophic lateral sclerosis (HP:0007354)1.67536847
130Sleep apnea (HP:0010535)1.67205800
131Abnormality of oral frenula (HP:0000190)1.65694697
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.65275535
133Eczematoid dermatitis (HP:0000976)1.64640294
134Disproportionate tall stature (HP:0001519)1.64005244
135Cerebral hypomyelination (HP:0006808)1.62055334
136Germ cell neoplasia (HP:0100728)1.61964705
137Foot dorsiflexor weakness (HP:0009027)1.60262174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.56635146
2EPHA43.68568685
3MAP3K93.54984930
4PRKD32.70006964
5MAP3K42.62408391
6DAPK22.47549064
7PAK62.23880196
8MINK12.20381627
9KSR22.15719034
10CDK122.13637286
11CAMKK12.13218849
12RIPK42.01480879
13MARK11.93525360
14NTRK21.87123319
15EEF2K1.81912818
16STK381.76865879
17MAP2K71.68775780
18NTRK11.64681306
19MAP2K41.62492744
20SGK31.51925786
21SIK21.50421181
22MAP3K131.49846714
23PRKCH1.44835681
24KSR11.44557068
25CAMK1G1.43760820
26TYRO31.40392828
27MAP3K21.40335374
28CDK51.39543794
29SGK21.38918307
30DAPK11.33201491
31SMG11.30318851
32ERN11.29817186
33SGK2231.29767939
34SGK4941.29767939
35SIK11.28617777
36RIPK11.20198662
37FES1.18995830
38TNIK1.15707231
39BMPR21.10218456
40WNK11.08896047
41FGFR41.06988150
42TRIB31.06383647
43RET1.05912566
44TAOK11.04601683
45MAPK121.03481968
46PRPF4B1.02671562
47UHMK11.02226848
48MAP3K121.00376776
49STK110.98786097
50ALK0.98539377
51LMTK20.97785024
52CAMKK20.96522064
53PRKCG0.96368280
54PDK10.91879913
55CDC42BPA0.89261582
56PNCK0.87868382
57MAP3K70.87641079
58SGK10.87224591
59CDK190.86600514
60PINK10.86560734
61NEK60.86092733
62CAMK10.85814031
63MAPK130.83548891
64MARK20.83388954
65PDGFRA0.82693114
66CAMK1D0.82433963
67PTK2B0.77738551
68PDPK10.77013227
69GRK50.76617783
70MAP2K30.75648714
71SCYL20.75392805
72PLK20.75343452
73MAP3K10.73923664
74ICK0.73192465
75PHKG20.72852354
76PHKG10.72852354
77MAP4K10.72667754
78OXSR10.72147983
79BRAF0.71168051
80TNK20.69963615
81WNK40.68568591
82MTOR0.68139680
83JAK20.67767334
84DMPK0.65610842
85CAMK2A0.65254535
86MAP3K110.64377656
87PAK30.61579429
88RPS6KA30.60357167
89CDK150.58640779
90DYRK1A0.58554412
91RAF10.58469974
92CDK180.57622058
93CAMK40.57475753
94TYK20.57346310
95ZAP700.56794771
96WNK30.56237321
97IRAK20.55906425
98FGFR20.55843926
99RPS6KA20.53991308
100PRKD20.52486625
101MAPK110.52212678
102HIPK20.52177464
103BMX0.49782005
104CDK11A0.47466388
105CDK140.46944905
106MAPK100.46938555
107FYN0.46711291
108PDGFRB0.46536962
109CAMK2B0.44366530
110TAOK20.44129302
111MAP3K100.43537467
112PKN20.43526690
113FGFR30.43483953
114INSRR0.43224624
115CASK0.42829505
116SYK0.42784133
117PDK30.42752264
118PDK40.42752264
119PRKCZ0.42402826
120MAP3K60.42192598
121ARAF0.41667643
122LATS20.41549245
123CCNB10.41412923
124CSNK1G20.40678781
125IRAK30.40337475
126HCK0.39591424
127JAK10.38940356
128TTN0.37771977
129PTK60.36583940

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.87152189
2Synaptic vesicle cycle_Homo sapiens_hsa047212.82571556
3Olfactory transduction_Homo sapiens_hsa047402.44307013
4Circadian entrainment_Homo sapiens_hsa047132.40890778
5Long-term potentiation_Homo sapiens_hsa047202.40672205
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27787651
7GABAergic synapse_Homo sapiens_hsa047272.24307435
8Glutamatergic synapse_Homo sapiens_hsa047242.22011594
9Morphine addiction_Homo sapiens_hsa050322.17601761
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15860335
11Amphetamine addiction_Homo sapiens_hsa050312.11363086
12Insulin secretion_Homo sapiens_hsa049112.04778458
13Salivary secretion_Homo sapiens_hsa049701.99083124
14Dopaminergic synapse_Homo sapiens_hsa047281.84250738
15Gastric acid secretion_Homo sapiens_hsa049711.84208349
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82577087
17Cholinergic synapse_Homo sapiens_hsa047251.71152753
18Type II diabetes mellitus_Homo sapiens_hsa049301.63021273
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.61616334
20Renin secretion_Homo sapiens_hsa049241.60132044
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58770448
22Oxytocin signaling pathway_Homo sapiens_hsa049211.49947505
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47801857
24Cocaine addiction_Homo sapiens_hsa050301.47470585
25Taste transduction_Homo sapiens_hsa047421.45898394
26Long-term depression_Homo sapiens_hsa047301.41528626
27Calcium signaling pathway_Homo sapiens_hsa040201.39777847
28GnRH signaling pathway_Homo sapiens_hsa049121.37320284
29B cell receptor signaling pathway_Homo sapiens_hsa046621.33678773
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32838630
31Acute myeloid leukemia_Homo sapiens_hsa052211.32441026
32Nitrogen metabolism_Homo sapiens_hsa009101.32369349
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31620801
34* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29911662
35Chronic myeloid leukemia_Homo sapiens_hsa052201.28093362
36cAMP signaling pathway_Homo sapiens_hsa040241.26046945
37Dorso-ventral axis formation_Homo sapiens_hsa043201.21641718
38Glioma_Homo sapiens_hsa052141.21139500
39Gap junction_Homo sapiens_hsa045401.18897602
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18541506
41Serotonergic synapse_Homo sapiens_hsa047261.17297769
42Estrogen signaling pathway_Homo sapiens_hsa049151.16460862
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12767020
44Prion diseases_Homo sapiens_hsa050201.11339931
45Collecting duct acid secretion_Homo sapiens_hsa049661.08377652
46Other glycan degradation_Homo sapiens_hsa005111.06886281
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03117777
48ErbB signaling pathway_Homo sapiens_hsa040121.02997574
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02120860
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00549643
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.92181141
52Pancreatic secretion_Homo sapiens_hsa049720.90107424
53Osteoclast differentiation_Homo sapiens_hsa043800.88697681
54Thyroid hormone synthesis_Homo sapiens_hsa049180.88457453
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.87969801
56Pancreatic cancer_Homo sapiens_hsa052120.87453224
57Melanogenesis_Homo sapiens_hsa049160.86384384
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86363387
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85113572
60mTOR signaling pathway_Homo sapiens_hsa041500.84817823
61Dilated cardiomyopathy_Homo sapiens_hsa054140.83776083
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82070604
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.80233985
64T cell receptor signaling pathway_Homo sapiens_hsa046600.78816498
65Axon guidance_Homo sapiens_hsa043600.78495226
66Glucagon signaling pathway_Homo sapiens_hsa049220.75876901
67Choline metabolism in cancer_Homo sapiens_hsa052310.75835580
68MAPK signaling pathway_Homo sapiens_hsa040100.75760512
69HIF-1 signaling pathway_Homo sapiens_hsa040660.72946217
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69417178
71VEGF signaling pathway_Homo sapiens_hsa043700.68413950
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68348751
73Phototransduction_Homo sapiens_hsa047440.67022546
74* Inositol phosphate metabolism_Homo sapiens_hsa005620.66694662
75Bile secretion_Homo sapiens_hsa049760.66522916
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64727406
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63492625
78Notch signaling pathway_Homo sapiens_hsa043300.63262008
79Vibrio cholerae infection_Homo sapiens_hsa051100.62589938
80Endometrial cancer_Homo sapiens_hsa052130.62476609
81Rap1 signaling pathway_Homo sapiens_hsa040150.61909868
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61851751
83Oocyte meiosis_Homo sapiens_hsa041140.61785308
84Non-small cell lung cancer_Homo sapiens_hsa052230.61393172
85Thyroid cancer_Homo sapiens_hsa052160.60575673
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60545077
87Circadian rhythm_Homo sapiens_hsa047100.60308799
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60217299
89Vitamin B6 metabolism_Homo sapiens_hsa007500.59177391
90Type I diabetes mellitus_Homo sapiens_hsa049400.58871412
91Colorectal cancer_Homo sapiens_hsa052100.58161449
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58071026
93Endocytosis_Homo sapiens_hsa041440.57848408
94Insulin signaling pathway_Homo sapiens_hsa049100.56493362
95Tuberculosis_Homo sapiens_hsa051520.54257107
96Hepatitis B_Homo sapiens_hsa051610.53122506
97Ras signaling pathway_Homo sapiens_hsa040140.52343562
98Chemokine signaling pathway_Homo sapiens_hsa040620.51324539
99Amoebiasis_Homo sapiens_hsa051460.50920085
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.50473735
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.49514810
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49055194
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48950424
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47617430
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.46811556
106Leishmaniasis_Homo sapiens_hsa051400.46572525
107Renal cell carcinoma_Homo sapiens_hsa052110.46566183
108Insulin resistance_Homo sapiens_hsa049310.46250924
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46203026
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44445253
111Cardiac muscle contraction_Homo sapiens_hsa042600.43078527
112Fatty acid biosynthesis_Homo sapiens_hsa000610.43010535
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42822135
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.41536150
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40884855
116Prolactin signaling pathway_Homo sapiens_hsa049170.40753253
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40370847
118Platelet activation_Homo sapiens_hsa046110.37540096
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36767821
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.36255101
121Wnt signaling pathway_Homo sapiens_hsa043100.34371076
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33231453
123Ovarian steroidogenesis_Homo sapiens_hsa049130.32520731
124AMPK signaling pathway_Homo sapiens_hsa041520.32115206

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