PHYHIPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.80524503
2central nervous system myelination (GO:0022010)6.80524503
3neuron cell-cell adhesion (GO:0007158)4.84262515
4synaptic vesicle docking involved in exocytosis (GO:0016081)4.52850771
5mechanosensory behavior (GO:0007638)4.34224227
6myelination (GO:0042552)4.31457729
7axon ensheathment (GO:0008366)4.27492275
8ensheathment of neurons (GO:0007272)4.27492275
9L-amino acid import (GO:0043092)4.27302560
10locomotory exploration behavior (GO:0035641)4.22315882
11synaptic vesicle maturation (GO:0016188)4.19980914
12neuronal action potential propagation (GO:0019227)4.18816220
13synaptic vesicle exocytosis (GO:0016079)4.14164575
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.12245150
15regulation of synaptic vesicle exocytosis (GO:2000300)4.06898920
16sodium ion export (GO:0071436)4.05209319
17pyrimidine nucleobase catabolic process (GO:0006208)4.03876211
18presynaptic membrane assembly (GO:0097105)4.01864592
19regulation of synapse structural plasticity (GO:0051823)3.98589436
20presynaptic membrane organization (GO:0097090)3.98376296
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.91877752
22amino acid import (GO:0043090)3.88382667
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.87338158
24glutamate secretion (GO:0014047)3.82807116
25negative regulation of neurotransmitter transport (GO:0051589)3.80607206
26fatty acid elongation (GO:0030497)3.78358564
27negative regulation of neurotransmitter secretion (GO:0046929)3.74542750
28long-chain fatty acid biosynthetic process (GO:0042759)3.73484486
29transmission of nerve impulse (GO:0019226)3.66643842
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.65589814
31gamma-aminobutyric acid transport (GO:0015812)3.64571822
32protein localization to synapse (GO:0035418)3.64571539
33acidic amino acid transport (GO:0015800)3.61332737
34vocalization behavior (GO:0071625)3.60713999
35potassium ion import (GO:0010107)3.49498549
36positive regulation of synapse maturation (GO:0090129)3.48875762
37neuron recognition (GO:0008038)3.48324728
38regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.48238130
39regulation of synaptic vesicle transport (GO:1902803)3.47171905
40adult walking behavior (GO:0007628)3.43625301
41nucleobase catabolic process (GO:0046113)3.39138706
42establishment of mitochondrion localization (GO:0051654)3.37901743
43glutamate receptor signaling pathway (GO:0007215)3.36563281
44negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35400101
45synaptic transmission, glutamatergic (GO:0035249)3.32442591
46cellular sodium ion homeostasis (GO:0006883)3.31459078
47potassium ion homeostasis (GO:0055075)3.31138901
48oligodendrocyte differentiation (GO:0048709)3.29461519
49neuronal ion channel clustering (GO:0045161)3.26152807
50cerebellar granule cell differentiation (GO:0021707)3.23283737
51positive regulation of dendritic spine morphogenesis (GO:0061003)3.22186618
52neuron-neuron synaptic transmission (GO:0007270)3.20967462
53exploration behavior (GO:0035640)3.20913848
54L-glutamate transport (GO:0015813)3.20509464
55regulation of neuronal synaptic plasticity (GO:0048168)3.17576721
56dendritic spine morphogenesis (GO:0060997)3.16633461
57positive regulation of synapse assembly (GO:0051965)3.14786067
58apical protein localization (GO:0045176)3.13133501
59neurotransmitter secretion (GO:0007269)3.11691236
60gamma-aminobutyric acid signaling pathway (GO:0007214)3.10667566
61cellular potassium ion homeostasis (GO:0030007)3.09530120
62dendrite morphogenesis (GO:0048813)3.09412706
63synaptic vesicle endocytosis (GO:0048488)3.08763527
64layer formation in cerebral cortex (GO:0021819)3.08589143
65positive regulation of dendritic spine development (GO:0060999)3.08581848
66cerebral cortex radially oriented cell migration (GO:0021799)3.08321651
67cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08312113
68regulation of glutamate receptor signaling pathway (GO:1900449)3.08274982
69axonal fasciculation (GO:0007413)3.04137949
70photoreceptor cell differentiation (GO:0046530)3.03520544
71eye photoreceptor cell differentiation (GO:0001754)3.03520544
72regulation of respiratory system process (GO:0044065)3.02822539
73neurotransmitter-gated ion channel clustering (GO:0072578)3.02720928
74regulation of neurotransmitter transport (GO:0051588)3.00159998
75negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.98140666
76asymmetric protein localization (GO:0008105)2.96859530
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96053434
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93637268
79regulation of long-term neuronal synaptic plasticity (GO:0048169)2.92583607
80neurotransmitter uptake (GO:0001504)2.92094738
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.90401911
82substantia nigra development (GO:0021762)2.90325893
83cell migration in hindbrain (GO:0021535)2.90057623
84neuromuscular synaptic transmission (GO:0007274)2.89733915
85membrane depolarization during action potential (GO:0086010)2.89438833
86regulation of dendritic spine morphogenesis (GO:0061001)2.88974952
87neurotransmitter transport (GO:0006836)2.87479784
88regulation of synapse maturation (GO:0090128)2.86985103
89positive regulation of membrane potential (GO:0045838)2.86940938
90synapse organization (GO:0050808)2.86439557
91long-term memory (GO:0007616)2.85859736
92cochlea development (GO:0090102)2.85844128
93negative regulation of axonogenesis (GO:0050771)2.85312711
94glycine transport (GO:0015816)2.82698351
95membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.82319982
96myelin maintenance (GO:0043217)2.81183430
97long-term synaptic potentiation (GO:0060291)2.80733173
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80517747
99central nervous system projection neuron axonogenesis (GO:0021952)2.77283669
100regulation of excitatory postsynaptic membrane potential (GO:0060079)2.76945490
101startle response (GO:0001964)2.76874041
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.75323491
103regulation of voltage-gated calcium channel activity (GO:1901385)2.75284300
104mating behavior (GO:0007617)2.74880122
105membrane depolarization (GO:0051899)2.74879748
106synaptic vesicle transport (GO:0048489)2.74026517
107establishment of synaptic vesicle localization (GO:0097480)2.74026517
108membrane hyperpolarization (GO:0060081)2.73881215
109negative regulation of protein localization to cell surface (GO:2000009)2.73734208
110glycerophospholipid catabolic process (GO:0046475)2.72158899
111regulation of neurotransmitter secretion (GO:0046928)2.71434509
112response to auditory stimulus (GO:0010996)2.71381534
113regulation of vesicle fusion (GO:0031338)2.70906190
114response to methylmercury (GO:0051597)2.68900604
115regulation of synaptic transmission, glutamatergic (GO:0051966)2.68805560
116postsynaptic membrane organization (GO:0001941)2.68708679
117auditory behavior (GO:0031223)2.68651340
118synapse assembly (GO:0007416)2.68344945
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.68249035
120neuromuscular process controlling posture (GO:0050884)2.67488728
121regulation of postsynaptic membrane potential (GO:0060078)2.64994215
122regulation of dendritic spine development (GO:0060998)2.64726640
123regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.63781876
124regulation of synaptic plasticity (GO:0048167)2.62166735
125regulation of neurotransmitter levels (GO:0001505)2.61874880
126neuron remodeling (GO:0016322)2.61730609
127adult locomotory behavior (GO:0008344)2.60228522
128regulation of collateral sprouting (GO:0048670)2.59379449
129C4-dicarboxylate transport (GO:0015740)2.57562041

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.76273518
2GBX2_23144817_ChIP-Seq_PC3_Human3.66509295
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90501938
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84609324
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78004346
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46721915
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46721915
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.37976653
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37864547
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35913201
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34717277
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33077331
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31601128
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30993181
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.21457763
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.19374244
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18271958
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.17304939
19TAF15_26573619_Chip-Seq_HEK293_Human2.12259897
20DROSHA_22980978_ChIP-Seq_HELA_Human2.05988794
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.04744760
22AR_21572438_ChIP-Seq_LNCaP_Human2.02596284
23* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.94455096
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87347124
25* RARB_27405468_Chip-Seq_BRAIN_Mouse1.86960550
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77110676
27* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76933930
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74869490
29* REST_18959480_ChIP-ChIP_MESCs_Mouse1.73372772
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71792326
31* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65143703
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.63127235
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62180195
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60073754
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59242278
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52782122
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50604267
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49155547
39SMAD4_21799915_ChIP-Seq_A2780_Human1.48088607
40P300_19829295_ChIP-Seq_ESCs_Human1.47499489
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46260775
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.45548335
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42900790
44VDR_22108803_ChIP-Seq_LS180_Human1.41545106
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41239362
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39773818
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38889251
48* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37991689
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.33861686
50* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33230150
51CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32929001
52RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31409482
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31316262
54ER_23166858_ChIP-Seq_MCF-7_Human1.30725719
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30056115
56ZNF274_21170338_ChIP-Seq_K562_Hela1.27581894
57* STAT3_23295773_ChIP-Seq_U87_Human1.22724087
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.22565291
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22503080
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21258828
61* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21193396
62FUS_26573619_Chip-Seq_HEK293_Human1.20701468
63* RNF2_27304074_Chip-Seq_NSC_Mouse1.19733948
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.15882734
65* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13583738
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12842261
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.12316983
68AR_25329375_ChIP-Seq_VCAP_Human1.11739009
69TCF4_23295773_ChIP-Seq_U87_Human1.10496427
70* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08396056
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07860207
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07491589
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05756103
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05129946
75* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04858658
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04621444
77IGF1R_20145208_ChIP-Seq_DFB_Human1.04314937
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.04164646
79CBP_20019798_ChIP-Seq_JUKART_Human1.04083966
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04083966
81JUN_21703547_ChIP-Seq_K562_Human1.04048583
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.03934556
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03494106
84* KDM2B_26808549_Chip-Seq_REH_Human1.03287969
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02236904
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.01682490
87GATA1_26923725_Chip-Seq_HPCs_Mouse1.00635288
88RUNX2_22187159_ChIP-Seq_PCA_Human1.00470697
89* SOX9_26525672_Chip-Seq_HEART_Mouse1.00239562
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.00081322
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99486193
92P53_22387025_ChIP-Seq_ESCs_Mouse0.98695502
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98656812
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98642679
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97493313
96* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97316990
97* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97001895
98AHR_22903824_ChIP-Seq_MCF-7_Human0.96136145
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95845123
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.94193214
101AR_19668381_ChIP-Seq_PC3_Human0.94169520
102CMYC_18555785_Chip-Seq_ESCs_Mouse0.92680400
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.91371939
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90828450
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90828450
106YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90118526
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88044517
108SMAD4_21741376_ChIP-Seq_EPCs_Human0.86893817
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85697886
110TAL1_26923725_Chip-Seq_HPCs_Mouse0.85361956
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85085050
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84729407
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.84460766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.71788024
2MP0004859_abnormal_synaptic_plasticity4.55999210
3MP0004270_analgesia3.81875390
4MP0003635_abnormal_synaptic_transmissio3.34559228
5MP0002064_seizures3.02525608
6MP0009046_muscle_twitch2.96518046
7MP0000920_abnormal_myelination2.95785956
8MP0001486_abnormal_startle_reflex2.92605705
9MP0005423_abnormal_somatic_nervous2.87542739
10MP0009745_abnormal_behavioral_response2.84234402
11MP0002272_abnormal_nervous_system2.76071390
12MP0002063_abnormal_learning/memory/cond2.59857602
13MP0003329_amyloid_beta_deposits2.59643165
14MP0002734_abnormal_mechanical_nocicepti2.46148443
15MP0002572_abnormal_emotion/affect_behav2.41465716
16MP0004885_abnormal_endolymph2.38344399
17MP0000778_abnormal_nervous_system2.22740295
18MP0001968_abnormal_touch/_nociception2.19943196
19MP0001529_abnormal_vocalization2.16067054
20MP0001440_abnormal_grooming_behavior2.15244785
21MP0003690_abnormal_glial_cell2.12269445
22MP0004142_abnormal_muscle_tone1.95553497
23MP0001905_abnormal_dopamine_level1.92586443
24MP0004742_abnormal_vestibular_system1.90030099
25MP0002735_abnormal_chemical_nociception1.86724511
26MP0002067_abnormal_sensory_capabilities1.85886486
27MP0002733_abnormal_thermal_nociception1.81103764
28MP0003634_abnormal_glial_cell1.78952385
29MP0005410_abnormal_fertilization1.77371229
30MP0001970_abnormal_pain_threshold1.77066962
31MP0008569_lethality_at_weaning1.76218985
32MP0002736_abnormal_nociception_after1.73162251
33MP0000955_abnormal_spinal_cord1.71935872
34MP0001485_abnormal_pinna_reflex1.67102730
35MP0005386_behavior/neurological_phenoty1.66221846
36MP0004924_abnormal_behavior1.66221846
37MP0001501_abnormal_sleep_pattern1.63362334
38MP0000566_synostosis1.60759886
39MP0002882_abnormal_neuron_morphology1.58463439
40MP0002822_catalepsy1.58039616
41MP0005646_abnormal_pituitary_gland1.54373101
42MP0002557_abnormal_social/conspecific_i1.53938800
43MP0002229_neurodegeneration1.53840955
44MP0005171_absent_coat_pigmentation1.52601543
45MP0005551_abnormal_eye_electrophysiolog1.51988190
46MP0002184_abnormal_innervation1.49507423
47MP0006276_abnormal_autonomic_nervous1.49326423
48MP0001984_abnormal_olfaction1.47636945
49MP0002066_abnormal_motor_capabilities/c1.46393706
50MP0003632_abnormal_nervous_system1.41185228
51MP0003633_abnormal_nervous_system1.36089133
52MP0003631_nervous_system_phenotype1.35345159
53MP0001502_abnormal_circadian_rhythm1.34717712
54MP0003136_yellow_coat_color1.33588173
55MP0005645_abnormal_hypothalamus_physiol1.26285594
56MP0001963_abnormal_hearing_physiology1.26225159
57MP0003121_genomic_imprinting1.25614274
58MP0004811_abnormal_neuron_physiology1.25585547
59MP0009780_abnormal_chondrocyte_physiolo1.24765150
60MP0003950_abnormal_plasma_membrane1.21729023
61MP0005409_darkened_coat_color1.18269801
62MP0000604_amyloidosis1.17542789
63MP0004858_abnormal_nervous_system1.17096593
64MP0004043_abnormal_pH_regulation1.16727675
65MP0005499_abnormal_olfactory_system1.16660361
66MP0005394_taste/olfaction_phenotype1.16660361
67MP0000569_abnormal_digit_pigmentation1.16572456
68MP0002752_abnormal_somatic_nervous1.13968240
69MP0002152_abnormal_brain_morphology1.13416282
70MP0004145_abnormal_muscle_electrophysio1.04913060
71MP0001299_abnormal_eye_distance/1.01257006
72MP0000462_abnormal_digestive_system0.94407363
73MP0005623_abnormal_meninges_morphology0.89920420
74MP0003787_abnormal_imprinting0.87817781
75MP0000631_abnormal_neuroendocrine_gland0.86549966
76MP0006292_abnormal_olfactory_placode0.85968602
77MP0002090_abnormal_vision0.85267713
78MP0006072_abnormal_retinal_apoptosis0.82898505
79MP0003122_maternal_imprinting0.81662456
80MP0002909_abnormal_adrenal_gland0.81598382
81MP0008877_abnormal_DNA_methylation0.81246039
82MP0005167_abnormal_blood-brain_barrier0.80986591
83MP0001177_atelectasis0.79866976
84MP0005187_abnormal_penis_morphology0.79813047
85MP0000026_abnormal_inner_ear0.79370212
86MP0005253_abnormal_eye_physiology0.79156476
87MP0005248_abnormal_Harderian_gland0.78647586
88MP0008789_abnormal_olfactory_epithelium0.77707197
89MP0003879_abnormal_hair_cell0.76762217
90MP0002069_abnormal_eating/drinking_beha0.75901936
91MP0001188_hyperpigmentation0.75345473
92MP0003137_abnormal_impulse_conducting0.74869994
93MP0005195_abnormal_posterior_eye0.74742720
94MP0000751_myopathy0.71303833
95MP0002751_abnormal_autonomic_nervous0.71037847
96MP0001986_abnormal_taste_sensitivity0.67105102
97MP0004085_abnormal_heartbeat0.66378689
98MP0003698_abnormal_male_reproductive0.66113998
99MP0000013_abnormal_adipose_tissue0.65925345
100MP0002638_abnormal_pupillary_reflex0.64271454
101MP0002234_abnormal_pharynx_morphology0.64137257
102MP0004134_abnormal_chest_morphology0.63757974
103MP0010386_abnormal_urinary_bladder0.63747428
104MP0004147_increased_porphyrin_level0.63644688
105MP0003861_abnormal_nervous_system0.62914308
106MP0003123_paternal_imprinting0.62782702
107MP0000747_muscle_weakness0.62491451
108MP0004133_heterotaxia0.62474058
109MP0002102_abnormal_ear_morphology0.62208880
110MP0001943_abnormal_respiration0.59011030
111MP0001664_abnormal_digestion0.58799011
112MP0000639_abnormal_adrenal_gland0.58338257
113MP0010770_preweaning_lethality0.57419235
114MP0002082_postnatal_lethality0.57419235
115MP0003938_abnormal_ear_development0.55846755
116MP0002653_abnormal_ependyma_morphology0.54166678
117MP0008874_decreased_physiological_sensi0.53856347
118MP0003172_abnormal_lysosome_physiology0.53671183
119MP0008872_abnormal_physiological_respon0.51496086
120MP0001348_abnormal_lacrimal_gland0.50486824

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.41361456
2Myokymia (HP:0002411)5.21870784
3Focal motor seizures (HP:0011153)5.05355223
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.43902071
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.43902071
6Supranuclear gaze palsy (HP:0000605)4.20684959
7Cerebral inclusion bodies (HP:0100314)4.14388118
8Epileptic encephalopathy (HP:0200134)3.84765457
9Abnormality of the corticospinal tract (HP:0002492)3.83222380
10Focal seizures (HP:0007359)3.77689445
11Ankle clonus (HP:0011448)3.55404688
12Peripheral hypomyelination (HP:0007182)3.54972922
13Dysmetria (HP:0001310)3.48392557
14Atonic seizures (HP:0010819)3.45508276
15Spastic gait (HP:0002064)3.44847252
16Hemiplegia (HP:0002301)3.36077408
17Intention tremor (HP:0002080)3.23665979
18Progressive cerebellar ataxia (HP:0002073)3.17289317
19Megalencephaly (HP:0001355)3.14405772
20Sensory axonal neuropathy (HP:0003390)3.06497379
21Action tremor (HP:0002345)3.06447117
22Scanning speech (HP:0002168)2.91014341
23Visual hallucinations (HP:0002367)2.88167276
24Termporal pattern (HP:0011008)2.84831832
25Insidious onset (HP:0003587)2.84831832
26Pheochromocytoma (HP:0002666)2.80189157
27Dysdiadochokinesis (HP:0002075)2.79665526
28Hyperventilation (HP:0002883)2.77966138
29Dialeptic seizures (HP:0011146)2.74079720
30Aplasia involving bones of the upper limbs (HP:0009823)2.70869451
31Aplasia of the phalanges of the hand (HP:0009802)2.70869451
32Aplasia involving bones of the extremities (HP:0009825)2.70869451
33Status epilepticus (HP:0002133)2.68929020
34Hypsarrhythmia (HP:0002521)2.67955687
35Broad-based gait (HP:0002136)2.64642183
36Retinal dysplasia (HP:0007973)2.64013592
37Clumsiness (HP:0002312)2.62520502
38Absence seizures (HP:0002121)2.61935528
39Hemiparesis (HP:0001269)2.61271218
40Amyotrophic lateral sclerosis (HP:0007354)2.60647876
41Generalized tonic-clonic seizures (HP:0002069)2.56400312
42Gaze-evoked nystagmus (HP:0000640)2.55356132
43Thickened helices (HP:0000391)2.54086459
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.53253426
45Absent/shortened dynein arms (HP:0200106)2.53253426
46Akinesia (HP:0002304)2.51203619
47Onion bulb formation (HP:0003383)2.48338661
48Febrile seizures (HP:0002373)2.47759895
49Progressive inability to walk (HP:0002505)2.43685642
50Lower limb muscle weakness (HP:0007340)2.42995105
51Hepatoblastoma (HP:0002884)2.42981400
52Cerebral hypomyelination (HP:0006808)2.42869129
53Abnormal eating behavior (HP:0100738)2.41694539
54Neuroendocrine neoplasm (HP:0100634)2.41645953
55Truncal ataxia (HP:0002078)2.39216321
56Abnormality of binocular vision (HP:0011514)2.37716042
57Diplopia (HP:0000651)2.37716042
58Urinary urgency (HP:0000012)2.37198002
59Alacrima (HP:0000522)2.31867347
60Postural instability (HP:0002172)2.31301217
61Mutism (HP:0002300)2.24528947
62Increased circulating renin level (HP:0000848)2.24112371
63Anxiety (HP:0000739)2.23552828
64Torticollis (HP:0000473)2.20457916
65Slow saccadic eye movements (HP:0000514)2.20288014
66Urinary bladder sphincter dysfunction (HP:0002839)2.19777036
67Abnormality of the lower motor neuron (HP:0002366)2.19649229
68Limb dystonia (HP:0002451)2.17818715
69Gait imbalance (HP:0002141)2.16623971
70Abnormal auditory evoked potentials (HP:0006958)2.16257441
71Depression (HP:0000716)2.16044869
72Absent speech (HP:0001344)2.12950361
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12788334
74Impaired vibration sensation in the lower limbs (HP:0002166)2.12173566
75Clonus (HP:0002169)2.11212264
76Split foot (HP:0001839)2.10195504
77Impaired social interactions (HP:0000735)2.09170223
78Abnormal social behavior (HP:0012433)2.09170223
79Generalized myoclonic seizures (HP:0002123)2.07413964
80Spastic tetraplegia (HP:0002510)2.04567606
81Oligodactyly (hands) (HP:0001180)2.02987999
82Polyphagia (HP:0002591)2.02257317
83Nephrogenic diabetes insipidus (HP:0009806)2.01612907
84Parakeratosis (HP:0001036)2.01023989
85Hypoplasia of the corpus callosum (HP:0002079)2.00998190
86Vaginal atresia (HP:0000148)1.99899596
87Leukodystrophy (HP:0002415)1.98045003
88Excessive salivation (HP:0003781)1.97164535
89Drooling (HP:0002307)1.97164535
90Genital tract atresia (HP:0001827)1.96185377
91Specific learning disability (HP:0001328)1.95689768
92Sleep apnea (HP:0010535)1.94948953
93Anteriorly placed anus (HP:0001545)1.93943573
94Abnormality of the labia minora (HP:0012880)1.93380545
95Neuronal loss in central nervous system (HP:0002529)1.88835585
96Metabolic alkalosis (HP:0200114)1.87997881
97Inability to walk (HP:0002540)1.85835604
98Abnormal respiratory motile cilium physiology (HP:0012261)1.85818535
99Medial flaring of the eyebrow (HP:0010747)1.85748593
100Morphological abnormality of the pyramidal tract (HP:0002062)1.84698496
101Bowel incontinence (HP:0002607)1.83849128
102Abnormal ciliary motility (HP:0012262)1.83338435
103Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.83272716
104Epidermoid cyst (HP:0200040)1.82715602
105Poor speech (HP:0002465)1.82688802
106Abnormality of saccadic eye movements (HP:0000570)1.82353344
107Epileptiform EEG discharges (HP:0011182)1.82139782
108Absent septum pellucidum (HP:0001331)1.82121272
109Blue irides (HP:0000635)1.81240609
110EEG with generalized epileptiform discharges (HP:0011198)1.80389363
111Amblyopia (HP:0000646)1.80192736
112Humeroradial synostosis (HP:0003041)1.80079305
113Synostosis involving the elbow (HP:0003938)1.80079305
114Decreased lacrimation (HP:0000633)1.79826420
115Impaired vibratory sensation (HP:0002495)1.79822990
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79392634
117Congenital primary aphakia (HP:0007707)1.77129732
118Poor eye contact (HP:0000817)1.76492050
119Focal dystonia (HP:0004373)1.76059588
120Muscular hypotonia of the trunk (HP:0008936)1.76005235
121Heterochromia iridis (HP:0001100)1.75800409
122Bradykinesia (HP:0002067)1.75619499
123Poor suck (HP:0002033)1.72839706
124Esotropia (HP:0000565)1.72532470
125True hermaphroditism (HP:0010459)1.70134134
126Abnormality of salivation (HP:0100755)1.69188143
127Lissencephaly (HP:0001339)1.68282675
128Oligodactyly (HP:0012165)1.67852562
129Genetic anticipation (HP:0003743)1.67782189
130Spastic tetraparesis (HP:0001285)1.67118333
131Delusions (HP:0000746)1.66201271
132Ulnar claw (HP:0001178)1.64963769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.81170977
2OXSR13.25222144
3EPHA43.11150858
4NTRK32.73115867
5MARK12.60991760
6CASK2.56119674
7CDK192.53117425
8TNIK2.40689341
9MAP3K92.15668707
10PNCK2.05410836
11PAK62.00972269
12NTRK11.99721684
13MAP3K41.91145216
14WNK41.86674611
15PRPF4B1.83740542
16NTRK21.80565813
17TYRO31.80507131
18BCR1.79584831
19MINK11.74875634
20PKN11.70881304
21UHMK11.70645782
22MAP2K71.65488661
23WNK11.57966802
24LIMK11.55965314
25PHKG21.47395424
26PHKG11.47395424
27EPHB11.39396609
28CDK51.38762754
29KSR21.38499516
30PRKD31.34647349
31SIK21.33320827
32MAP4K21.30139790
33MAPK131.29964336
34SGK4941.29509391
35SGK2231.29509391
36FES1.29136217
37SGK21.28765414
38CAMK2B1.28430929
39FGFR21.25746560
40NEK61.22290135
41ICK1.14590329
42ARAF1.10445912
43CSNK1G21.08959144
44ROCK21.08734558
45FGR1.05894140
46CAMK2A1.05717857
47CDK141.03182714
48MAPKAPK50.99383242
49DAPK20.98984816
50CSNK1G30.98363793
51CAMK2D0.97531193
52PAK30.96658472
53CDK150.96324734
54CDK180.96084282
55LMTK20.96026120
56EPHA30.94718223
57ERBB30.93983925
58FRK0.93703880
59MARK20.93374151
60MAP2K40.92425870
61PRKCG0.90708451
62CSNK1A1L0.89915756
63MET0.89346820
64KSR10.88726117
65CAMK2G0.86812958
66PLK20.86038034
67PINK10.85792224
68CDK11A0.84861976
69GRK50.80623557
70MAP3K20.79409465
71MUSK0.76946089
72MAP3K130.75497358
73TRIM280.74783023
74PRKCE0.73931265
75IRAK20.70774123
76WNK30.69719425
77STK110.68082417
78DYRK20.67780005
79DYRK1A0.67725488
80PDPK10.67579746
81CSNK1G10.67246915
82SGK30.66437384
83CAMK40.64028950
84BMPR1B0.62590163
85PTK2B0.62588968
86PRKCH0.62454763
87CAMKK10.59067019
88ERBB20.57724980
89FYN0.56189198
90PBK0.55627611
91PIK3CA0.55215161
92CAMK1G0.53891832
93PRKCQ0.52960401
94RIPK40.52915543
95BMPR20.52255299
96AKT30.52038038
97PDK10.51676469
98CCNB10.50755501
99MAP3K120.50395552
100RPS6KA30.48923244
101CSNK1D0.47453320
102SGK10.46603522
103ERBB40.45616030
104CDK30.45056776
105INSRR0.44132107
106CAMK10.43438348
107DYRK1B0.42812140
108PRKG10.41988502
109MAPK150.40806794
110CAMKK20.40251680
111RET0.39596566
112NME10.38615073
113CLK10.38569190
114MAPK100.37824918
115CSNK1E0.36428037
116TSSK60.36029774
117IRAK10.35223760
118ROCK10.35022372
119PRKCZ0.35011313
120DAPK10.34911207
121TNK20.34750390
122CSNK1A10.34730276
123PRKACA0.34269143
124STK380.29462481
125LATS20.29383258
126PRKACB0.29304341

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.01854138
2Synaptic vesicle cycle_Homo sapiens_hsa047212.80179742
3GABAergic synapse_Homo sapiens_hsa047272.63066688
4Glutamatergic synapse_Homo sapiens_hsa047242.44317108
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32385850
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.31041732
7Morphine addiction_Homo sapiens_hsa050322.23089370
8Circadian entrainment_Homo sapiens_hsa047132.13074018
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94142695
10Olfactory transduction_Homo sapiens_hsa047401.90371970
11Long-term potentiation_Homo sapiens_hsa047201.85906737
12Salivary secretion_Homo sapiens_hsa049701.83669051
13Steroid biosynthesis_Homo sapiens_hsa001001.83571453
14Collecting duct acid secretion_Homo sapiens_hsa049661.83026298
15Serotonergic synapse_Homo sapiens_hsa047261.79427163
16Amphetamine addiction_Homo sapiens_hsa050311.78995289
17Dopaminergic synapse_Homo sapiens_hsa047281.75105782
18Nitrogen metabolism_Homo sapiens_hsa009101.74845574
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67462461
20Axon guidance_Homo sapiens_hsa043601.66275740
21Long-term depression_Homo sapiens_hsa047301.66119819
22Cholinergic synapse_Homo sapiens_hsa047251.61954076
23Fatty acid elongation_Homo sapiens_hsa000621.61278328
24Insulin secretion_Homo sapiens_hsa049111.60319728
25Gastric acid secretion_Homo sapiens_hsa049711.60040800
26Ether lipid metabolism_Homo sapiens_hsa005651.57489123
27Cocaine addiction_Homo sapiens_hsa050301.52376940
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51642534
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49626167
30Taste transduction_Homo sapiens_hsa047421.46800871
31Renin secretion_Homo sapiens_hsa049241.32853888
32Oxidative phosphorylation_Homo sapiens_hsa001901.31319367
33Vibrio cholerae infection_Homo sapiens_hsa051101.30723891
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23654305
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16869015
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16848995
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16297898
38Cardiac muscle contraction_Homo sapiens_hsa042601.16075467
39Calcium signaling pathway_Homo sapiens_hsa040201.12523048
40Gap junction_Homo sapiens_hsa045401.12449940
41Oxytocin signaling pathway_Homo sapiens_hsa049211.12348663
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10298227
43Phototransduction_Homo sapiens_hsa047441.09762045
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08123525
45Dorso-ventral axis formation_Homo sapiens_hsa043201.03865432
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03449762
47Circadian rhythm_Homo sapiens_hsa047101.02788071
48cAMP signaling pathway_Homo sapiens_hsa040241.01268887
49Alzheimers disease_Homo sapiens_hsa050101.00446847
50ErbB signaling pathway_Homo sapiens_hsa040120.99739120
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99353783
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99028186
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98541626
54Butanoate metabolism_Homo sapiens_hsa006500.94852871
55Sphingolipid metabolism_Homo sapiens_hsa006000.94351198
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.92980213
57GnRH signaling pathway_Homo sapiens_hsa049120.91340539
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.90757956
59Fatty acid biosynthesis_Homo sapiens_hsa000610.89674213
60Pancreatic secretion_Homo sapiens_hsa049720.87716030
61Renal cell carcinoma_Homo sapiens_hsa052110.87486796
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85369778
63Parkinsons disease_Homo sapiens_hsa050120.85111148
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.84365957
65Fatty acid metabolism_Homo sapiens_hsa012120.82427233
66Histidine metabolism_Homo sapiens_hsa003400.82195863
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81953873
68Sulfur metabolism_Homo sapiens_hsa009200.80098910
69Melanogenesis_Homo sapiens_hsa049160.78301932
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75504066
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75054597
72Choline metabolism in cancer_Homo sapiens_hsa052310.72526609
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71366068
74Estrogen signaling pathway_Homo sapiens_hsa049150.71365422
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69733488
76beta-Alanine metabolism_Homo sapiens_hsa004100.69178074
77Ras signaling pathway_Homo sapiens_hsa040140.68273217
78Arginine and proline metabolism_Homo sapiens_hsa003300.68087666
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68068127
80Endocytosis_Homo sapiens_hsa041440.67151740
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66563186
82Vitamin B6 metabolism_Homo sapiens_hsa007500.64713487
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.60884248
84Thyroid hormone synthesis_Homo sapiens_hsa049180.58869816
85Propanoate metabolism_Homo sapiens_hsa006400.57425895
86Ovarian steroidogenesis_Homo sapiens_hsa049130.56938650
87Arginine biosynthesis_Homo sapiens_hsa002200.56438617
88Type II diabetes mellitus_Homo sapiens_hsa049300.56094135
89PPAR signaling pathway_Homo sapiens_hsa033200.55094338
90Regulation of autophagy_Homo sapiens_hsa041400.54022454
91MAPK signaling pathway_Homo sapiens_hsa040100.52106895
92Rheumatoid arthritis_Homo sapiens_hsa053230.51571777
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51376502
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51150726
95Tight junction_Homo sapiens_hsa045300.50306374
96Prion diseases_Homo sapiens_hsa050200.49731876
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.49684521
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49307229
99Glioma_Homo sapiens_hsa052140.47803510
100Mineral absorption_Homo sapiens_hsa049780.47182086
101Huntingtons disease_Homo sapiens_hsa050160.46742013
102Oocyte meiosis_Homo sapiens_hsa041140.46511110
103Peroxisome_Homo sapiens_hsa041460.44784419
104Alcoholism_Homo sapiens_hsa050340.44446251
105ABC transporters_Homo sapiens_hsa020100.43290702
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42771249
107Hedgehog signaling pathway_Homo sapiens_hsa043400.42430336
108Wnt signaling pathway_Homo sapiens_hsa043100.40429940
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.38385498
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38360013
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38264022
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37594169
113Dilated cardiomyopathy_Homo sapiens_hsa054140.37361049
114Linoleic acid metabolism_Homo sapiens_hsa005910.36586905
115Inositol phosphate metabolism_Homo sapiens_hsa005620.36433577
116Glucagon signaling pathway_Homo sapiens_hsa049220.36178593
117Bile secretion_Homo sapiens_hsa049760.36161778
118Hippo signaling pathway_Homo sapiens_hsa043900.35755080
119Rap1 signaling pathway_Homo sapiens_hsa040150.35706739
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35254022
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34668276
122AMPK signaling pathway_Homo sapiens_hsa041520.33477566
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.30778817
124Protein export_Homo sapiens_hsa030600.30135759
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30121622

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