PHYHIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.70141394
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.50867627
3locomotory exploration behavior (GO:0035641)6.46984482
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.29471597
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.62646300
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.59902797
7vocalization behavior (GO:0071625)5.50929285
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.49655985
9synaptic vesicle exocytosis (GO:0016079)5.48425602
10glutamate secretion (GO:0014047)5.38238823
11regulation of glutamate receptor signaling pathway (GO:1900449)5.21880699
12regulation of synaptic vesicle exocytosis (GO:2000300)5.18075207
13regulation of neuronal synaptic plasticity (GO:0048168)5.03024400
14neuronal action potential propagation (GO:0019227)5.00832150
15regulation of synapse structural plasticity (GO:0051823)4.98650115
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.98181729
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.92746951
18exploration behavior (GO:0035640)4.71494531
19neurotransmitter secretion (GO:0007269)4.70806245
20regulation of synaptic vesicle transport (GO:1902803)4.65401610
21amino acid import (GO:0043090)4.54074121
22synaptic transmission, glutamatergic (GO:0035249)4.50721697
23neurotransmitter-gated ion channel clustering (GO:0072578)4.47714207
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.45958479
25protein localization to synapse (GO:0035418)4.43640588
26long-term memory (GO:0007616)4.41287556
27glutamate receptor signaling pathway (GO:0007215)4.33247984
28potassium ion homeostasis (GO:0055075)4.28587095
29cellular potassium ion homeostasis (GO:0030007)4.24361042
30regulation of excitatory postsynaptic membrane potential (GO:0060079)4.19086393
31dendritic spine morphogenesis (GO:0060997)4.19072988
32positive regulation of membrane potential (GO:0045838)4.18341778
33neuron-neuron synaptic transmission (GO:0007270)4.18254126
34gamma-aminobutyric acid transport (GO:0015812)4.12404726
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.12282369
36sodium ion export (GO:0071436)4.10818831
37regulation of synapse maturation (GO:0090128)4.07279526
38axon ensheathment in central nervous system (GO:0032291)4.06961136
39central nervous system myelination (GO:0022010)4.06961136
40neuromuscular process controlling balance (GO:0050885)4.01456462
41regulation of synaptic plasticity (GO:0048167)3.98235719
42regulation of dendritic spine morphogenesis (GO:0061001)3.97850629
43layer formation in cerebral cortex (GO:0021819)3.94746462
44negative regulation of dendrite morphogenesis (GO:0050774)3.94452307
45positive regulation of synapse maturation (GO:0090129)3.93628113
46regulation of postsynaptic membrane potential (GO:0060078)3.88025819
47postsynaptic membrane organization (GO:0001941)3.87252796
48prepulse inhibition (GO:0060134)3.78438379
49positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.75659487
50auditory behavior (GO:0031223)3.73488770
51neuromuscular process controlling posture (GO:0050884)3.72510964
52long-term synaptic potentiation (GO:0060291)3.71912976
53activation of protein kinase A activity (GO:0034199)3.66591025
54cerebellar Purkinje cell differentiation (GO:0021702)3.65915106
55neurotransmitter transport (GO:0006836)3.64857853
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.56345946
57regulation of neurotransmitter secretion (GO:0046928)3.55746814
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.55684281
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.54905731
60proline transport (GO:0015824)3.51652402
61cytoskeletal anchoring at plasma membrane (GO:0007016)3.51542063
62positive regulation of neurotransmitter transport (GO:0051590)3.50962839
63neuron cell-cell adhesion (GO:0007158)3.49580239
64regulation of neurotransmitter levels (GO:0001505)3.49392758
65positive regulation of neurotransmitter secretion (GO:0001956)3.48350116
66cerebellar granule cell differentiation (GO:0021707)3.47873818
67neurotransmitter uptake (GO:0001504)3.45631778
68transmission of nerve impulse (GO:0019226)3.44655091
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.43134713
70acidic amino acid transport (GO:0015800)3.40660474
71vesicle docking involved in exocytosis (GO:0006904)3.40239666
72G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.40008580
73cell communication by electrical coupling (GO:0010644)3.39950118
74glycine transport (GO:0015816)3.38664880
75regulation of neurotransmitter transport (GO:0051588)3.36344737
76response to auditory stimulus (GO:0010996)3.36008548
77regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.34547085
78membrane depolarization (GO:0051899)3.33101362
79synaptic vesicle endocytosis (GO:0048488)3.31644017
80G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30285735
81dendritic spine organization (GO:0097061)3.29565775
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.29077929
83establishment of synaptic vesicle localization (GO:0097480)3.28291936
84synaptic vesicle transport (GO:0048489)3.28291936
85neuronal ion channel clustering (GO:0045161)3.27977614
86regulation of ARF protein signal transduction (GO:0032012)3.26053779
87regulation of vesicle fusion (GO:0031338)3.25568091
88regulation of voltage-gated calcium channel activity (GO:1901385)3.24367583
89negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.23876637
90cell differentiation in hindbrain (GO:0021533)3.23710315
91gamma-aminobutyric acid signaling pathway (GO:0007214)3.23112393
92membrane depolarization during action potential (GO:0086010)3.23072303
93neuromuscular synaptic transmission (GO:0007274)3.22315271
94membrane hyperpolarization (GO:0060081)3.21813453
95regulation of dendritic spine development (GO:0060998)3.21370592
96L-amino acid import (GO:0043092)3.20426830
97positive regulation of synaptic transmission (GO:0050806)3.19491361
98neuromuscular process (GO:0050905)3.17981874
99behavioral fear response (GO:0001662)3.17370240
100behavioral defense response (GO:0002209)3.17370240
101positive regulation of dendritic spine development (GO:0060999)3.16743075
102regulation of exocytosis (GO:0017157)3.16426565
103regulation of synaptic transmission (GO:0050804)3.15291409
104chemosensory behavior (GO:0007635)3.14237426
105long term synaptic depression (GO:0060292)3.13492040
106negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13276316
107vesicle docking (GO:0048278)3.13250785
108learning (GO:0007612)3.11157935
109positive regulation of dendritic spine morphogenesis (GO:0061003)3.09193983
110cell communication involved in cardiac conduction (GO:0086065)3.08333367
111regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.07896710
112positive regulation of dendrite development (GO:1900006)3.07405152
113signal release (GO:0023061)3.07207015
114potassium ion import (GO:0010107)3.06439440
115cellular sodium ion homeostasis (GO:0006883)3.02649164
116visual learning (GO:0008542)3.01736609
117synaptic transmission (GO:0007268)3.00560182
118behavioral response to cocaine (GO:0048148)2.99744332
119dendrite morphogenesis (GO:0048813)2.98977190
120mechanosensory behavior (GO:0007638)2.98337179
121fear response (GO:0042596)2.97802581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.88466195
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.30768400
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.21285105
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17352349
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05874563
6DROSHA_22980978_ChIP-Seq_HELA_Human2.92383012
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.89933616
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.89933616
9REST_21632747_ChIP-Seq_MESCs_Mouse2.87343880
10GBX2_23144817_ChIP-Seq_PC3_Human2.81445414
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77570944
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.75782456
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.66332766
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63825932
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63691918
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.56438373
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52533001
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50308140
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.44977344
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.44072950
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.40163122
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39586947
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.38756325
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.27908343
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.18105709
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96676822
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.90236722
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77708642
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77349061
30AR_21572438_ChIP-Seq_LNCaP_Human1.66288158
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.64776961
32RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.49560742
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48269356
34KDM2B_26808549_Chip-Seq_K562_Human1.43177744
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43060631
36SMAD4_21799915_ChIP-Seq_A2780_Human1.38310652
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.37649591
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36895373
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35640743
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32106806
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31701855
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31600818
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30580599
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30188984
45WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28130060
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26409354
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25354713
48AR_19668381_ChIP-Seq_PC3_Human1.24074268
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22310592
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.21097610
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.19027590
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16641529
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16139971
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16003338
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15903481
56ZNF274_21170338_ChIP-Seq_K562_Hela1.13540528
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13239922
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.13094233
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.09840879
60* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09434742
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09417629
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08316322
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08033287
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07130537
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06628389
66OCT4_19829295_ChIP-Seq_ESCs_Human1.04806490
67AR_25329375_ChIP-Seq_VCAP_Human1.04345468
68STAT3_23295773_ChIP-Seq_U87_Human1.04184714
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03470477
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03074267
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.02621732
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02154511
73TET1_21490601_ChIP-Seq_MESCs_Mouse1.01634953
74CTCF_27219007_Chip-Seq_Bcells_Human1.00748343
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.00467681
76ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98844281
77DPY_21335234_ChIP-Seq_ESCs_Mouse0.98634003
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98379660
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96306704
80RXR_22108803_ChIP-Seq_LS180_Human0.96121486
81SMAD3_21741376_ChIP-Seq_HESCs_Human0.95656130
82KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94139757
83YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93737229
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92984796
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91765135
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91131118
87RNF2_27304074_Chip-Seq_NSC_Mouse0.90974869
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90863099
89P300_19829295_ChIP-Seq_ESCs_Human0.89907317
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89882332
91TAF15_26573619_Chip-Seq_HEK293_Human0.89879553
92TCF4_23295773_ChIP-Seq_U87_Human0.89815220
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.89450888
94SMAD4_21741376_ChIP-Seq_HESCs_Human0.89430462
95* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89087658
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88841685
97* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88826276
98KLF4_19829295_ChIP-Seq_ESCs_Human0.87868280
99EGR1_19032775_ChIP-ChIP_M12_Human0.85502236
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.85495864
101CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85307508
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84632537
103SMC4_20622854_ChIP-Seq_HELA_Human0.83485029
104TP53_16413492_ChIP-PET_HCT116_Human0.83412052
105AHR_22903824_ChIP-Seq_MCF-7_Human0.83157683
106* CREB1_26743006_Chip-Seq_LNCaP_Human0.82971136
107KDM2B_26808549_Chip-Seq_DND41_Human0.82522957
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82473585
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81553855
110SMAD4_21741376_ChIP-Seq_ESCs_Human0.81490453
111TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80992631
112TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80916263
113LXR_22292898_ChIP-Seq_THP-1_Human0.80749336
114CBX2_27304074_Chip-Seq_ESCs_Mouse0.79617108
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79333052
116RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79247823
117P68_20966046_ChIP-Seq_HELA_Human0.78358326
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78323241
119* MYC_19915707_ChIP-ChIP_AK7_Human0.77212749
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.76975877
121PRDM14_20953172_ChIP-Seq_ESCs_Human0.76838105
122SMAD4_21741376_ChIP-Seq_EPCs_Human0.76256634
123GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.73715116
124TP53_20018659_ChIP-ChIP_R1E_Mouse0.73032618
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.72985325
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.71786901
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.71033659
128TP53_23651856_ChIP-Seq_MEFs_Mouse0.70712989
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70664410
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.65696004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.67778181
2MP0003635_abnormal_synaptic_transmissio4.51623440
3MP0003880_abnormal_central_pattern4.44558838
4MP0002822_catalepsy4.40490818
5MP0009745_abnormal_behavioral_response3.69028847
6MP0004270_analgesia3.65055188
7MP0002063_abnormal_learning/memory/cond3.56442890
8MP0009046_muscle_twitch3.45404251
9MP0002064_seizures3.38083807
10MP0002572_abnormal_emotion/affect_behav2.90274450
11MP0001968_abnormal_touch/_nociception2.75264020
12MP0002272_abnormal_nervous_system2.74866758
13MP0001486_abnormal_startle_reflex2.63054540
14MP0005423_abnormal_somatic_nervous2.58597311
15MP0002734_abnormal_mechanical_nocicepti2.44409026
16MP0001501_abnormal_sleep_pattern2.37102754
17MP0008569_lethality_at_weaning2.37003384
18MP0002736_abnormal_nociception_after2.04893100
19MP0001440_abnormal_grooming_behavior2.00797526
20MP0009780_abnormal_chondrocyte_physiolo1.94730190
21MP0002909_abnormal_adrenal_gland1.93720110
22MP0003329_amyloid_beta_deposits1.87402822
23MP0002067_abnormal_sensory_capabilities1.84673859
24MP0004811_abnormal_neuron_physiology1.83374640
25MP0002735_abnormal_chemical_nociception1.81938084
26MP0001970_abnormal_pain_threshold1.80848162
27MP0002733_abnormal_thermal_nociception1.77100217
28MP0005386_behavior/neurological_phenoty1.75415348
29MP0004924_abnormal_behavior1.75415348
30MP0005646_abnormal_pituitary_gland1.74420119
31MP0004858_abnormal_nervous_system1.71135468
32MP0002557_abnormal_social/conspecific_i1.70386183
33MP0003879_abnormal_hair_cell1.68928492
34MP0002184_abnormal_innervation1.60050567
35MP0004885_abnormal_endolymph1.52371382
36MP0003123_paternal_imprinting1.49916762
37MP0003633_abnormal_nervous_system1.48493859
38MP0000955_abnormal_spinal_cord1.44068886
39MP0003075_altered_response_to1.43893596
40MP0002066_abnormal_motor_capabilities/c1.43355151
41MP0003787_abnormal_imprinting1.32059944
42MP0000778_abnormal_nervous_system1.31271222
43MP0002882_abnormal_neuron_morphology1.30543237
44MP0001984_abnormal_olfaction1.29671416
45MP0003631_nervous_system_phenotype1.24873625
46MP0008872_abnormal_physiological_respon1.19851325
47MP0001502_abnormal_circadian_rhythm1.17909396
48MP0001529_abnormal_vocalization1.14202979
49MP0004142_abnormal_muscle_tone1.13365440
50MP0008874_decreased_physiological_sensi1.09330681
51MP0004147_increased_porphyrin_level1.06522763
52MP0001905_abnormal_dopamine_level1.05742233
53MP0004145_abnormal_muscle_electrophysio1.05146466
54MP0003690_abnormal_glial_cell1.05128163
55MP0000751_myopathy1.04682789
56MP0008961_abnormal_basal_metabolism1.04308657
57MP0002152_abnormal_brain_morphology1.02523746
58MP0000013_abnormal_adipose_tissue1.02057670
59MP0001177_atelectasis1.01964844
60MP0005167_abnormal_blood-brain_barrier1.00495771
61MP0003283_abnormal_digestive_organ0.99929937
62MP0010234_abnormal_vibrissa_follicle0.99638867
63MP0001346_abnormal_lacrimal_gland0.99152816
64MP0002069_abnormal_eating/drinking_beha0.96353695
65MP0001348_abnormal_lacrimal_gland0.95615803
66MP0003632_abnormal_nervous_system0.92055817
67MP0005645_abnormal_hypothalamus_physiol0.90721838
68MP0000569_abnormal_digit_pigmentation0.89818524
69MP0004085_abnormal_heartbeat0.89703888
70MP0005535_abnormal_body_temperature0.86425340
71MP0000604_amyloidosis0.85725600
72MP0000920_abnormal_myelination0.85566870
73MP0002229_neurodegeneration0.84845188
74MP0004215_abnormal_myocardial_fiber0.79722258
75MP0001188_hyperpigmentation0.77465440
76MP0002638_abnormal_pupillary_reflex0.74921834
77MP0002090_abnormal_vision0.74889000
78MP0004043_abnormal_pH_regulation0.74761308
79MP0003634_abnormal_glial_cell0.73388627
80MP0006276_abnormal_autonomic_nervous0.73248472
81MP0003122_maternal_imprinting0.72259490
82MP0004510_myositis0.72020955
83MP0004742_abnormal_vestibular_system0.71691371
84MP0003137_abnormal_impulse_conducting0.71573155
85MP0008877_abnormal_DNA_methylation0.71402384
86MP0001986_abnormal_taste_sensitivity0.68876386
87MP0005394_taste/olfaction_phenotype0.64403150
88MP0005499_abnormal_olfactory_system0.64403150
89MP0005409_darkened_coat_color0.63342477
90MP0004484_altered_response_of0.63255179
91MP0001963_abnormal_hearing_physiology0.63152853
92MP0000579_abnormal_nail_morphology0.61927278
93MP0005551_abnormal_eye_electrophysiolog0.61460553
94MP0004233_abnormal_muscle_weight0.60013915
95MP0004130_abnormal_muscle_cell0.59512725
96MP0001485_abnormal_pinna_reflex0.58513921
97MP0005623_abnormal_meninges_morphology0.57248712
98MP0005166_decreased_susceptibility_to0.56610595
99MP0003172_abnormal_lysosome_physiology0.55997852
100MP0001664_abnormal_digestion0.52250789
101MP0010769_abnormal_survival0.51965294
102MP0010386_abnormal_urinary_bladder0.51441736
103MP0002752_abnormal_somatic_nervous0.50110401
104MP0003956_abnormal_body_size0.49539055
105MP0002082_postnatal_lethality0.49469268
106MP0010768_mortality/aging0.48562058
107MP0000631_abnormal_neuroendocrine_gland0.48184756
108MP0002089_abnormal_postnatal_growth/wei0.47553126
109MP0001943_abnormal_respiration0.47354503
110MP0010770_preweaning_lethality0.46658911
111MP0003045_fibrosis0.45586356
112MP0002873_normal_phenotype0.44802094
113MP0002169_no_abnormal_phenotype0.43161912
114MP0003861_abnormal_nervous_system0.42151108
115MP0003121_genomic_imprinting0.42048595

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.29684826
2Focal motor seizures (HP:0011153)7.83879431
3Focal seizures (HP:0007359)5.99218265
4Visual hallucinations (HP:0002367)5.62580417
5Action tremor (HP:0002345)5.05579616
6Progressive cerebellar ataxia (HP:0002073)4.70265480
7Epileptic encephalopathy (HP:0200134)4.60317997
8Atonic seizures (HP:0010819)4.41782813
9Febrile seizures (HP:0002373)4.31458386
10Gaze-evoked nystagmus (HP:0000640)4.04477370
11Absence seizures (HP:0002121)3.96732468
12Generalized tonic-clonic seizures (HP:0002069)3.81782257
13Poor eye contact (HP:0000817)3.80552176
14Cerebral hypomyelination (HP:0006808)3.79244155
15Dysdiadochokinesis (HP:0002075)3.76768920
16Impaired vibration sensation in the lower limbs (HP:0002166)3.72599408
17Depression (HP:0000716)3.70767019
18Abnormality of the lower motor neuron (HP:0002366)3.69405756
19Annular pancreas (HP:0001734)3.68508641
20Broad-based gait (HP:0002136)3.68006611
21Dialeptic seizures (HP:0011146)3.64587938
22Ankle clonus (HP:0011448)3.56224341
23Dysmetria (HP:0001310)3.48984931
24Dysmetric saccades (HP:0000641)3.45598181
25Anxiety (HP:0000739)3.44107056
26Impaired social interactions (HP:0000735)3.41070554
27Abnormal social behavior (HP:0012433)3.41070554
28Limb dystonia (HP:0002451)3.34977090
29Impaired smooth pursuit (HP:0007772)3.31669052
30Postural instability (HP:0002172)3.27794036
31Intention tremor (HP:0002080)3.17391718
32Torticollis (HP:0000473)3.15717909
33Supranuclear gaze palsy (HP:0000605)3.15247500
34Scanning speech (HP:0002168)3.14469227
35Ventricular fibrillation (HP:0001663)3.14461874
36Truncal ataxia (HP:0002078)3.11311113
37Urinary bladder sphincter dysfunction (HP:0002839)3.10157455
38Hemiplegia (HP:0002301)3.09079855
39Abnormal eating behavior (HP:0100738)3.01553041
40Focal dystonia (HP:0004373)3.00086695
41Papilledema (HP:0001085)2.95612297
42Genetic anticipation (HP:0003743)2.95205511
43Abnormality of ocular smooth pursuit (HP:0000617)2.92105395
44Stereotypic behavior (HP:0000733)2.85179600
45Akinesia (HP:0002304)2.85055097
46Bundle branch block (HP:0011710)2.80725432
47Mutism (HP:0002300)2.75010264
48Urinary urgency (HP:0000012)2.71518205
49Pointed chin (HP:0000307)2.69065850
50Apathy (HP:0000741)2.68178531
51Amblyopia (HP:0000646)2.64886041
52Craniofacial dystonia (HP:0012179)2.61426911
53Impaired vibratory sensation (HP:0002495)2.59198968
54Hemiparesis (HP:0001269)2.58164295
55Sleep apnea (HP:0010535)2.57767663
56Spastic gait (HP:0002064)2.57563899
57Bradykinesia (HP:0002067)2.57205785
58Status epilepticus (HP:0002133)2.55559938
59Resting tremor (HP:0002322)2.50964011
60Peripheral hypomyelination (HP:0007182)2.48470417
61Hyperventilation (HP:0002883)2.46947592
62Diplopia (HP:0000651)2.45905722
63Abnormality of binocular vision (HP:0011514)2.45905722
64Megalencephaly (HP:0001355)2.45523507
65Choreoathetosis (HP:0001266)2.41244802
66Diminished motivation (HP:0000745)2.39878956
67CNS hypomyelination (HP:0003429)2.32732091
68Abnormality of saccadic eye movements (HP:0000570)2.27729851
69Incomplete penetrance (HP:0003829)2.24030546
70Lower limb asymmetry (HP:0100559)2.23240443
71Tetraplegia (HP:0002445)2.21735490
72Obstructive sleep apnea (HP:0002870)2.19370931
73Ankyloglossia (HP:0010296)2.18214528
74Epileptiform EEG discharges (HP:0011182)2.15647269
75Abnormal EKG (HP:0003115)2.14716129
76Spinal canal stenosis (HP:0003416)2.13196764
77Gait ataxia (HP:0002066)2.12074814
78Clonus (HP:0002169)2.10260132
79Drooling (HP:0002307)2.09314374
80Excessive salivation (HP:0003781)2.09314374
81Progressive inability to walk (HP:0002505)2.08224392
82Insomnia (HP:0100785)2.08006873
83Fetal akinesia sequence (HP:0001989)2.07302806
84EEG with generalized epileptiform discharges (HP:0011198)2.06794149
85Morphological abnormality of the pyramidal tract (HP:0002062)2.03774998
86Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02917438
87Degeneration of the lateral corticospinal tracts (HP:0002314)2.02917438
88Abnormality of the periventricular white matter (HP:0002518)2.02617326
89Hypsarrhythmia (HP:0002521)2.01706688
90Lower limb muscle weakness (HP:0007340)2.00077149
91Neurofibrillary tangles (HP:0002185)1.96496504
92Generalized myoclonic seizures (HP:0002123)1.93204264
93Lower limb amyotrophy (HP:0007210)1.93035231
94Cerebral inclusion bodies (HP:0100314)1.92967710
95Memory impairment (HP:0002354)1.92387607
96Limb ataxia (HP:0002070)1.91600964
97Neuronal loss in central nervous system (HP:0002529)1.90550167
98Rigidity (HP:0002063)1.89177720
99Polyphagia (HP:0002591)1.88144223
100Increased circulating renin level (HP:0000848)1.85684441
101Absent speech (HP:0001344)1.84045243
102Aplasia involving bones of the extremities (HP:0009825)1.83911110
103Aplasia involving bones of the upper limbs (HP:0009823)1.83911110
104Aplasia of the phalanges of the hand (HP:0009802)1.83911110
105Prolonged QT interval (HP:0001657)1.83184829
106Postural tremor (HP:0002174)1.79983354
107Delusions (HP:0000746)1.79636411
108Unsteady gait (HP:0002317)1.78987324
109Slow saccadic eye movements (HP:0000514)1.77746848
110Heart block (HP:0012722)1.77415514
111Dementia (HP:0000726)1.76937258
112Iris hypopigmentation (HP:0007730)1.76389060
113Rapidly progressive (HP:0003678)1.76139614
114Hand muscle atrophy (HP:0009130)1.75452963
115Agitation (HP:0000713)1.72841805
116Termporal pattern (HP:0011008)1.72645700
117Insidious onset (HP:0003587)1.72645700
118Psychosis (HP:0000709)1.70797949
119Pheochromocytoma (HP:0002666)1.70582935
120Abnormality of the corticospinal tract (HP:0002492)1.69830904
121Slow progression (HP:0003677)1.68739145
122Spastic tetraparesis (HP:0001285)1.68463097
123Amyotrophic lateral sclerosis (HP:0007354)1.66424266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.37522432
2NTRK34.46938278
3MAP3K94.02600889
4DAPK23.12182647
5PRKD32.72160460
6KSR22.61454532
7MINK12.49068023
8CAMKK12.42223716
9MAP3K42.39079932
10PAK62.38835352
11NTRK21.90719065
12MAP2K71.84651069
13RIPK41.82799896
14ARAF1.80599014
15DAPK11.76889042
16MAP3K131.76544414
17PRPF4B1.74395118
18MARK11.73930764
19KSR11.69772643
20STK381.65749551
21CAMKK21.63634155
22NTRK11.59802411
23CDK191.59538468
24CDK51.58965747
25MAP2K41.55842089
26FES1.41430534
27TAOK11.36287333
28TYRO31.33980090
29MAP3K21.33548484
30MAP3K121.25880584
31TNIK1.23720666
32CAMK11.21382700
33PRKCG1.20251557
34GRK51.18916285
35RIPK11.16282052
36PINK11.14324963
37PLK21.10355627
38PRKCH1.10299557
39SIK21.07263626
40UHMK11.07093088
41RAF11.05563567
42SGK2231.01431473
43SGK4941.01431473
44PTK2B0.99546679
45ALK0.97858886
46CDK180.97440741
47CDK150.96887222
48STK110.96527537
49SGK30.89417239
50PDK10.89169249
51SGK20.87676738
52CDK140.87197078
53MAPK120.87175372
54CDK11A0.85047341
55NEK10.84864502
56CAMK2A0.83745041
57PDPK10.82328434
58MAPK130.79968458
59MAP3K10.78783416
60LMTK20.78689384
61CAMK2B0.76559678
62RET0.75211125
63CASK0.74038868
64MAP3K110.72739358
65SGK10.71534169
66CAMK40.71249425
67OXSR10.70046939
68MARK20.67682696
69PKN10.66603744
70BRSK10.64385409
71LIMK10.63991977
72PHKG20.62331323
73PHKG10.62331323
74TNK20.61749636
75BMPR20.61018794
76WNK10.60566198
77PAK30.59183639
78NEK60.58698271
79DAPK30.57458041
80RPS6KA30.54439059
81MAP3K70.53902563
82DYRK1A0.52993346
83CDC42BPA0.51611721
84PNCK0.49987137
85CAMK2G0.47944897
86LATS20.47646980
87ROCK20.47584241
88TESK10.47504738
89FGFR20.47409384
90DMPK0.47107235
91MAP2K10.46935295
92FYN0.45654130
93PRKCZ0.41203147
94MAPK100.41116095
95PRKG20.40265286
96CAMK2D0.39986653
97BRAF0.38721958
98FER0.35711059
99MOS0.34978319
100PRKD20.34473529
101IRAK20.31312010
102PRKCE0.30141208
103TRIB30.29619783
104PRKCB0.29191556
105PRKCA0.29099486
106MAPKAPK50.28763577
107CCNB10.28610802
108ROCK10.28539085
109ERBB20.28132452
110MAP2K60.27269587
111CAMK1G0.26501327
112MAPK80.26082494
113SCYL20.25161674
114TAOK20.24764135
115SRC0.23548952
116JAK20.23248298

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.44538244
2Synaptic vesicle cycle_Homo sapiens_hsa047213.25153080
3Olfactory transduction_Homo sapiens_hsa047403.04542169
4Long-term potentiation_Homo sapiens_hsa047202.85001920
5Circadian entrainment_Homo sapiens_hsa047132.81363453
6Glutamatergic synapse_Homo sapiens_hsa047242.66121993
7GABAergic synapse_Homo sapiens_hsa047272.61606369
8Amphetamine addiction_Homo sapiens_hsa050312.61453450
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56523568
10Morphine addiction_Homo sapiens_hsa050322.49620460
11Salivary secretion_Homo sapiens_hsa049702.23127611
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20321525
13Dopaminergic synapse_Homo sapiens_hsa047282.13336885
14Insulin secretion_Homo sapiens_hsa049112.03852495
15Aldosterone synthesis and secretion_Homo sapiens_hsa049252.02556615
16Gastric acid secretion_Homo sapiens_hsa049712.02052307
17Cholinergic synapse_Homo sapiens_hsa047251.98072051
18Nitrogen metabolism_Homo sapiens_hsa009101.76787062
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76555442
20Vitamin B6 metabolism_Homo sapiens_hsa007501.76081992
21Oxytocin signaling pathway_Homo sapiens_hsa049211.75561894
22Long-term depression_Homo sapiens_hsa047301.74822534
23Cocaine addiction_Homo sapiens_hsa050301.72122442
24Calcium signaling pathway_Homo sapiens_hsa040201.64781302
25Renin secretion_Homo sapiens_hsa049241.60410188
26Taste transduction_Homo sapiens_hsa047421.57528845
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53608337
28GnRH signaling pathway_Homo sapiens_hsa049121.52449251
29Serotonergic synapse_Homo sapiens_hsa047261.40266796
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35873629
31cAMP signaling pathway_Homo sapiens_hsa040241.35269492
32Gap junction_Homo sapiens_hsa045401.33675893
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32095517
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27020361
35Type II diabetes mellitus_Homo sapiens_hsa049301.26933472
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23988463
37Glioma_Homo sapiens_hsa052141.20326484
38Estrogen signaling pathway_Homo sapiens_hsa049151.16246941
39Collecting duct acid secretion_Homo sapiens_hsa049661.10971867
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08190984
41Melanogenesis_Homo sapiens_hsa049160.99568998
42ErbB signaling pathway_Homo sapiens_hsa040120.97201707
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95267112
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.94491401
45Pancreatic secretion_Homo sapiens_hsa049720.93458363
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.93327358
47Oocyte meiosis_Homo sapiens_hsa041140.91564949
48Thyroid hormone synthesis_Homo sapiens_hsa049180.86300957
49Cardiac muscle contraction_Homo sapiens_hsa042600.84297776
50Dorso-ventral axis formation_Homo sapiens_hsa043200.83461260
51Axon guidance_Homo sapiens_hsa043600.79272027
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79195871
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78204324
54Dilated cardiomyopathy_Homo sapiens_hsa054140.77966065
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77886894
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72800271
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71576206
58Choline metabolism in cancer_Homo sapiens_hsa052310.71312193
59VEGF signaling pathway_Homo sapiens_hsa043700.68939063
60MAPK signaling pathway_Homo sapiens_hsa040100.68076590
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67844623
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.67824120
63Vibrio cholerae infection_Homo sapiens_hsa051100.63979257
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62939916
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62276160
66Bile secretion_Homo sapiens_hsa049760.61280033
67Glucagon signaling pathway_Homo sapiens_hsa049220.60361318
68Rap1 signaling pathway_Homo sapiens_hsa040150.58348609
69Non-small cell lung cancer_Homo sapiens_hsa052230.57552770
70mTOR signaling pathway_Homo sapiens_hsa041500.57145593
71Inositol phosphate metabolism_Homo sapiens_hsa005620.56301658
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54405720
73Endocytosis_Homo sapiens_hsa041440.54104238
74Alcoholism_Homo sapiens_hsa050340.52389703
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.50640280
76Arginine and proline metabolism_Homo sapiens_hsa003300.48933025
77Circadian rhythm_Homo sapiens_hsa047100.48726995
78Ras signaling pathway_Homo sapiens_hsa040140.48718733
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48336042
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47888982
81Type I diabetes mellitus_Homo sapiens_hsa049400.47464557
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44261213
83Phototransduction_Homo sapiens_hsa047440.43721080
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43427326
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42472633
86Chemokine signaling pathway_Homo sapiens_hsa040620.41760683
87Prion diseases_Homo sapiens_hsa050200.41311914
88Endometrial cancer_Homo sapiens_hsa052130.39419298
89Arginine biosynthesis_Homo sapiens_hsa002200.35927360
90Insulin signaling pathway_Homo sapiens_hsa049100.35695633
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35093893
92Mineral absorption_Homo sapiens_hsa049780.34683567
93African trypanosomiasis_Homo sapiens_hsa051430.34317792
94Renal cell carcinoma_Homo sapiens_hsa052110.33314759
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32395637
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30769652
97Wnt signaling pathway_Homo sapiens_hsa043100.30262852
98Histidine metabolism_Homo sapiens_hsa003400.29024184
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28338002
100HIF-1 signaling pathway_Homo sapiens_hsa040660.28166085
101Ovarian steroidogenesis_Homo sapiens_hsa049130.28034735
102Fatty acid biosynthesis_Homo sapiens_hsa000610.27590309
103Platelet activation_Homo sapiens_hsa046110.27290779
104Alzheimers disease_Homo sapiens_hsa050100.25561931
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24884451
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24030538
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.23971751
108AMPK signaling pathway_Homo sapiens_hsa041520.22079205
109Tight junction_Homo sapiens_hsa045300.19468972
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19160726
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.18137242
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16970608
113beta-Alanine metabolism_Homo sapiens_hsa004100.16086128

Most similar genes based on co-expression Upload to Enrichr

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