PHYH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the PhyH family and encodes a peroxisomal protein that is involved in the alpha-oxidation of 3-methyl branched fatty acids. Specifically, this protein converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. Mutations in this gene have been associated with Refsum disease (RD) and deficient protein activity has been associated with Zellweger syndrome and rhizomelic chondrodysplasia punctata. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.26832368
2L-phenylalanine catabolic process (GO:0006559)7.26832368
3L-phenylalanine metabolic process (GO:0006558)6.97574898
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.97574898
5aromatic amino acid family catabolic process (GO:0009074)6.50894215
6indole-containing compound catabolic process (GO:0042436)5.86595119
7indolalkylamine catabolic process (GO:0046218)5.86595119
8tryptophan catabolic process (GO:0006569)5.86595119
9glyoxylate metabolic process (GO:0046487)5.81590804
10kynurenine metabolic process (GO:0070189)5.76888897
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.68842327
12bile acid biosynthetic process (GO:0006699)5.61611057
13tryptophan metabolic process (GO:0006568)5.56369424
14actin-myosin filament sliding (GO:0033275)5.43266603
15muscle filament sliding (GO:0030049)5.43266603
16cysteine metabolic process (GO:0006534)5.37183466
17alpha-linolenic acid metabolic process (GO:0036109)5.30181871
18sulfur amino acid catabolic process (GO:0000098)5.27048912
19epoxygenase P450 pathway (GO:0019373)5.25307336
20urea metabolic process (GO:0019627)5.21594500
21urea cycle (GO:0000050)5.21594500
22lysine metabolic process (GO:0006553)5.19675568
23lysine catabolic process (GO:0006554)5.19675568
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.06085805
25serine family amino acid catabolic process (GO:0009071)4.96355743
26high-density lipoprotein particle remodeling (GO:0034375)4.92575221
27complement activation, alternative pathway (GO:0006957)4.92574300
28negative regulation of fibrinolysis (GO:0051918)4.88047754
29nitrogen cycle metabolic process (GO:0071941)4.82140403
30regulation of protein activation cascade (GO:2000257)4.82025039
31peptidyl-glutamic acid carboxylation (GO:0017187)4.81655863
32protein carboxylation (GO:0018214)4.81655863
33homocysteine metabolic process (GO:0050667)4.78969238
34aromatic amino acid family metabolic process (GO:0009072)4.75567832
35creatine metabolic process (GO:0006600)4.74480083
36bile acid metabolic process (GO:0008206)4.73826536
37regulation of fibrinolysis (GO:0051917)4.71606636
38amino-acid betaine metabolic process (GO:0006577)4.70655093
39NADH metabolic process (GO:0006734)4.70027482
40regulation of triglyceride catabolic process (GO:0010896)4.64758769
41sarcoplasmic reticulum calcium ion transport (GO:0070296)4.63073851
42cellular ketone body metabolic process (GO:0046950)4.61057408
43alpha-amino acid catabolic process (GO:1901606)4.59680877
44actin-mediated cell contraction (GO:0070252)4.56515126
45tyrosine metabolic process (GO:0006570)4.53622654
46regulation of complement activation (GO:0030449)4.53130541
47reverse cholesterol transport (GO:0043691)4.33340639
48omega-hydroxylase P450 pathway (GO:0097267)4.32741487
49acylglycerol homeostasis (GO:0055090)4.31962755
50triglyceride homeostasis (GO:0070328)4.31962755
51cellular amino acid catabolic process (GO:0009063)4.31227299
52regulation of cholesterol esterification (GO:0010872)4.30559960
53coenzyme catabolic process (GO:0009109)4.29140835
54regulation of skeletal muscle contraction (GO:0014819)4.28718436
55protein-lipid complex remodeling (GO:0034368)4.26440717
56macromolecular complex remodeling (GO:0034367)4.26440717
57plasma lipoprotein particle remodeling (GO:0034369)4.26440717
58phenylpropanoid metabolic process (GO:0009698)4.20261659
59indolalkylamine metabolic process (GO:0006586)4.19540452
60glutamate metabolic process (GO:0006536)4.17532182
61ethanol oxidation (GO:0006069)4.16772983
62blood coagulation, intrinsic pathway (GO:0007597)4.12572953
63skeletal muscle contraction (GO:0003009)4.12265323
64cellular modified amino acid catabolic process (GO:0042219)4.10177207
65fructose metabolic process (GO:0006000)4.09922869
66short-chain fatty acid metabolic process (GO:0046459)4.09329392
67negative regulation of sterol transport (GO:0032372)4.06933182
68negative regulation of cholesterol transport (GO:0032375)4.06933182
69cellular glucuronidation (GO:0052695)4.06700232
70amine catabolic process (GO:0009310)4.04198313
71cellular biogenic amine catabolic process (GO:0042402)4.04198313
72phospholipid efflux (GO:0033700)4.03773384
73bile acid and bile salt transport (GO:0015721)4.03659436
74acetyl-CoA metabolic process (GO:0006084)4.01692988
75serine family amino acid metabolic process (GO:0009069)4.01616413
76glycine metabolic process (GO:0006544)4.01239537
772-oxoglutarate metabolic process (GO:0006103)3.99161945
78ketone body metabolic process (GO:1902224)3.98493379
79aspartate family amino acid catabolic process (GO:0009068)3.98129556
80dicarboxylic acid biosynthetic process (GO:0043650)3.98032741
81benzene-containing compound metabolic process (GO:0042537)3.97650808
82drug metabolic process (GO:0017144)3.96603111
83plasma lipoprotein particle clearance (GO:0034381)3.95912482
84drug catabolic process (GO:0042737)3.92909281
85fatty acid beta-oxidation (GO:0006635)3.92651932
86ethanol metabolic process (GO:0006067)3.89416222
87oxaloacetate metabolic process (GO:0006107)3.89000164
88imidazole-containing compound metabolic process (GO:0052803)3.87566541
89* carboxylic acid catabolic process (GO:0046395)3.85769432
90* organic acid catabolic process (GO:0016054)3.85769432
91aldehyde catabolic process (GO:0046185)3.79230816
92oxidative demethylation (GO:0070989)3.75311825
93* fatty acid oxidation (GO:0019395)3.74694424
94arginine metabolic process (GO:0006525)3.73180906
95regulation of relaxation of muscle (GO:1901077)3.70881890
96cholesterol efflux (GO:0033344)3.70728313
97drug transmembrane transport (GO:0006855)3.70495218
98* monocarboxylic acid catabolic process (GO:0072329)3.68579926
99* lipid oxidation (GO:0034440)3.67685905
100serine family amino acid biosynthetic process (GO:0009070)3.66897644
101glucuronate metabolic process (GO:0019585)3.65833535
102uronic acid metabolic process (GO:0006063)3.65833535
103phospholipid homeostasis (GO:0055091)3.64675344
104* fatty acid catabolic process (GO:0009062)3.63591997
105tricarboxylic acid cycle (GO:0006099)3.62679154
106carnitine metabolic process (GO:0009437)3.60336307
107regulation of bile acid biosynthetic process (GO:0070857)3.60107230
108positive regulation of lipid catabolic process (GO:0050996)3.57407539
109exogenous drug catabolic process (GO:0042738)3.56311900
110urate metabolic process (GO:0046415)3.56121089
111valine metabolic process (GO:0006573)3.55830368
112cofactor catabolic process (GO:0051187)3.55177590
113low-density lipoprotein particle remodeling (GO:0034374)3.51508543
114cytolysis (GO:0019835)3.50924538
115response to muscle activity (GO:0014850)3.50667343
116plasma lipoprotein particle assembly (GO:0034377)3.49959036
117regulation of cholesterol homeostasis (GO:2000188)3.49703481
118gluconeogenesis (GO:0006094)3.49315215
119fibrinolysis (GO:0042730)3.48855602
120flavonoid metabolic process (GO:0009812)3.48825363
121positive regulation of lipoprotein lipase activity (GO:0051006)3.46970260
122positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.41843033
123regulation of plasminogen activation (GO:0010755)3.31732575
124response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.30341407
125glycogen catabolic process (GO:0005980)3.30041462
126branched-chain amino acid catabolic process (GO:0009083)3.27047609
127actin filament-based movement (GO:0030048)3.25834873
128xenobiotic catabolic process (GO:0042178)3.24654558
129branched-chain amino acid metabolic process (GO:0009081)3.24281899
130hexose biosynthetic process (GO:0019319)3.24028310
131response to mercury ion (GO:0046689)3.21518697
132myofibril assembly (GO:0030239)3.20970322
133regulation of sequestering of triglyceride (GO:0010889)3.18175409
134polyketide metabolic process (GO:0030638)3.17606996
135doxorubicin metabolic process (GO:0044598)3.17606996
136daunorubicin metabolic process (GO:0044597)3.17606996
137positive regulation of triglyceride lipase activity (GO:0061365)3.16274782
138striated muscle contraction (GO:0006941)3.14844539
139negative regulation of hemostasis (GO:1900047)3.11690574
140negative regulation of blood coagulation (GO:0030195)3.11690574
141glucan catabolic process (GO:0009251)3.09375675
142arginine catabolic process (GO:0006527)3.08011049
143regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.06809218
144sarcomere organization (GO:0045214)3.01102019

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.94919108
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.85621621
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.32826281
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.21481300
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.48965400
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.09016422
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.65452342
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.95336364
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.82719573
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.59542682
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50299638
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06652822
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.05485865
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2858761
15* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98748022
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98255790
17CLOCK_20551151_ChIP-Seq_293T_Human1.69699566
18* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60493881
19GATA1_22025678_ChIP-Seq_K562_Human1.57434412
20IGF1R_20145208_ChIP-Seq_DFB_Human1.54795276
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.46365864
22HTT_18923047_ChIP-ChIP_STHdh_Human1.44880177
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43458666
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38956661
25* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37987398
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.35996191
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33398095
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33281678
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.33255703
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.29760508
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27664372
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25901972
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24263554
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22497171
35CRX_20693478_ChIP-Seq_RETINA_Mouse1.20731884
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.16573637
37CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.15962062
38PHF8_20622853_ChIP-Seq_HELA_Human1.14036868
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13750412
40MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.13721997
41GBX2_23144817_ChIP-Seq_PC3_Human1.12480766
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.12000596
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11108742
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10346294
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09329791
46RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08722732
47SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08248928
48GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08107463
49HNFA_21074721_ChIP-Seq_CACO-2_Human1.07877661
50SOX2_19829295_ChIP-Seq_ESCs_Human1.07839043
51NANOG_19829295_ChIP-Seq_ESCs_Human1.07839043
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07253716
53VDR_22108803_ChIP-Seq_LS180_Human1.06937542
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02809722
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02194659
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02036729
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00095932
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99335337
59GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98589824
60CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97430176
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96359614
62GATA6_21074721_ChIP-Seq_CACO-2_Human0.96208619
63* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96180929
64PIAS1_25552417_ChIP-Seq_VCAP_Human0.95995436
65ER_23166858_ChIP-Seq_MCF-7_Human0.95104312
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94727618
67OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94558243
68PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92829119
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91706404
70FLI1_27457419_Chip-Seq_LIVER_Mouse0.91587774
71ZNF263_19887448_ChIP-Seq_K562_Human0.91308940
72RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90321949
73GATA4_25053715_ChIP-Seq_YYC3_Human0.88090887
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87269826
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87073833
76AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86057182
77PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85925069
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85258831
79ESR2_21235772_ChIP-Seq_MCF-7_Human0.84991692
80P53_22387025_ChIP-Seq_ESCs_Mouse0.84514882
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84467307
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84150320
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82845959
84NFYB_21822215_ChIP-Seq_K562_Human0.82805127
85RBPJ_21746931_ChIP-Seq_IB4_Human0.82069645
86* ZFX_18555785_Chip-Seq_ESCs_Mouse0.81699627
87NFYA_21822215_ChIP-Seq_K562_Human0.81670973
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80889937
89STAT3_18555785_Chip-Seq_ESCs_Mouse0.80674992
90PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.79869601
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79690342
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77399203
93* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.76638109
94SOX2_18555785_Chip-Seq_ESCs_Mouse0.76608326
95CBX2_22325352_ChIP-Seq_293T-Rex_Human0.76299314
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76105631
97NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76105631
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75907858
99* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.72717885
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.72498772
101ESR1_15608294_ChIP-ChIP_MCF-7_Human0.71139475
102IRF8_22096565_ChIP-ChIP_GC-B_Human0.70943474
103* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69780542
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69492977
105RARA_24833708_ChIP-Seq_LIVER_Mouse0.68342196
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.67734833
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.66945597
108ESR1_21235772_ChIP-Seq_MCF-7_Human0.66519283
109SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65846405
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.65380989
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65183360
112* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64971274
113AR_20517297_ChIP-Seq_VCAP_Human0.63028065
114EGR1_19032775_ChIP-ChIP_M12_Human0.62795733
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.62154168
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.62123599
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62074652
118CEBPB_22108803_ChIP-Seq_LS180_Human0.61773415
119FOXA1_25552417_ChIP-Seq_VCAP_Human0.59260881
120TBX20_22080862_ChIP-Seq_HEART_Mouse0.57697159
121TBX20_22328084_ChIP-Seq_HEART_Mouse0.57697159
122RARB_24833708_ChIP-Seq_LIVER_Mouse0.57669580
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56417855
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56113130
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.55407582
126LXR_22292898_ChIP-Seq_THP-1_Human0.54918071
127CDX2_20551321_ChIP-Seq_CACO-2_Human0.53031576
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.52924807
129ESET_19884257_ChIP-Seq_ESCs_Mouse0.52916591
130BCAT_22108803_ChIP-Seq_LS180_Human0.52021383
131MYC_19915707_ChIP-ChIP_AK7_Human0.51441705
132* CBP_21632823_ChIP-Seq_H3396_Human0.51095672
133TAF2_19829295_ChIP-Seq_ESCs_Human0.50673612
134* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49640701
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.49551613
136STAT1_17558387_ChIP-Seq_HELA_Human0.49465918
137PPAR_26484153_Chip-Seq_NCI-H1993_Human0.49441586
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.49058351
139SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47564446
140ERG_20517297_ChIP-Seq_VCAP_Human0.47323804
141* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47199817
142ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.47061148
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47000415
144P53_21459846_ChIP-Seq_SAOS-2_Human0.46281165
145GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.45680637
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.44784069
147GATA2_19941826_ChIP-Seq_K562_Human0.44663326
148SOX2_20726797_ChIP-Seq_SW620_Human0.44599810
149GATA1_19941826_ChIP-Seq_K562_Human0.44298335
150GATA3_24758297_ChIP-Seq_MCF-7_Human0.44283641
151* GATA6_25053715_ChIP-Seq_YYC3_Human0.42800261
152PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.42136566
153CDX2_22108803_ChIP-Seq_LS180_Human0.41523600
154TAF15_26573619_Chip-Seq_HEK293_Human0.41451209
155GATA1_19941827_ChIP-Seq_MEL_Mouse0.41294166
156OCT4_20526341_ChIP-Seq_ESCs_Human0.40475014
157NCOR_22424771_ChIP-Seq_293T_Human0.40026195
158* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39606371

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.90427487
2MP0005360_urolithiasis7.31432123
3MP0005085_abnormal_gallbladder_physiolo6.16790701
4MP0005365_abnormal_bile_salt5.94045818
5MP0008875_abnormal_xenobiotic_pharmacok4.92792004
6MP0003806_abnormal_nucleotide_metabolis4.13792764
7MP0004145_abnormal_muscle_electrophysio3.88732993
8MP0003252_abnormal_bile_duct3.82294251
9MP0000751_myopathy3.64295596
10MP0010329_abnormal_lipoprotein_level3.40863280
11MP0000749_muscle_degeneration3.25738780
12MP0003195_calcinosis3.04982984
13MP0005332_abnormal_amino_acid3.02417022
14MP0009840_abnormal_foam_cell3.00156003
15MP0005083_abnormal_biliary_tract2.76588240
16MP0001666_abnormal_nutrient_absorption2.61233501
17MP0004019_abnormal_vitamin_homeostasis2.25368194
18MP0003191_abnormal_cellular_cholesterol2.16914622
19* MP0002118_abnormal_lipid_homeostasis2.10939456
20MP0002138_abnormal_hepatobiliary_system2.10249151
21MP0002106_abnormal_muscle_physiology2.06219454
22* MP0000609_abnormal_liver_physiology2.05806327
23MP0000747_muscle_weakness2.02858504
24MP0004087_abnormal_muscle_fiber1.90382645
25* MP0005319_abnormal_enzyme/_coenzyme1.87265816
26MP0003868_abnormal_feces_composition1.79324513
27MP0005369_muscle_phenotype1.76224734
28MP0005620_abnormal_muscle_contractility1.73896057
29MP0000759_abnormal_skeletal_muscle1.71030274
30MP0001764_abnormal_homeostasis1.69618661
31MP0004084_abnormal_cardiac_muscle1.68116179
32MP0005584_abnormal_enzyme/coenzyme_acti1.66787295
33MP0002837_dystrophic_cardiac_calcinosis1.56466720
34MP0004215_abnormal_myocardial_fiber1.56014515
35MP0009643_abnormal_urine_homeostasis1.54742158
36MP0002972_abnormal_cardiac_muscle1.47426220
37MP0004233_abnormal_muscle_weight1.40898828
38MP0003186_abnormal_redox_activity1.39325103
39MP0009780_abnormal_chondrocyte_physiolo1.38437908
40MP0009697_abnormal_copulation1.37570292
41MP0005451_abnormal_body_composition1.33956550
42MP0006036_abnormal_mitochondrial_physio1.29074876
43MP0000750_abnormal_muscle_regeneration1.27019066
44MP0000013_abnormal_adipose_tissue1.26360245
45MP0005670_abnormal_white_adipose1.23509706
46MP0004130_abnormal_muscle_cell1.18094947
47MP0005636_abnormal_mineral_homeostasis1.15582281
48MP0003011_delayed_dark_adaptation1.12434236
49MP0003656_abnormal_erythrocyte_physiolo1.10851167
50MP0001544_abnormal_cardiovascular_syste1.08341485
51MP0005385_cardiovascular_system_phenoty1.08341485
52* MP0000598_abnormal_liver_morphology1.07243214
53MP0005647_abnormal_sex_gland1.04356042
54MP0004484_altered_response_of1.04107505
55MP0002108_abnormal_muscle_morphology1.00918801
56MP0009764_decreased_sensitivity_to1.00106949
57MP0004043_abnormal_pH_regulation0.99644503
58MP0002876_abnormal_thyroid_physiology0.99499755
59MP0002078_abnormal_glucose_homeostasis0.99014909
60MP0002127_abnormal_cardiovascular_syste0.96611758
61MP0000604_amyloidosis0.96562367
62MP0005535_abnormal_body_temperature0.94999272
63MP0003705_abnormal_hypodermis_morpholog0.94130449
64MP0009763_increased_sensitivity_to0.91586583
65MP0002971_abnormal_brown_adipose0.90444398
66* MP0009642_abnormal_blood_homeostasis0.90113030
67MP0001756_abnormal_urination0.90088907
68MP0000003_abnormal_adipose_tissue0.87389538
69MP0005084_abnormal_gallbladder_morpholo0.87021824
70MP0008775_abnormal_heart_ventricle0.86056941
71MP0002254_reproductive_system_inflammat0.83723632
72MP0003879_abnormal_hair_cell0.83512140
73MP0006138_congestive_heart_failure0.83256037
74* MP0008469_abnormal_protein_level0.82863677
75MP0005187_abnormal_penis_morphology0.82672222
76MP0005376_homeostasis/metabolism_phenot0.82625651
77MP0010368_abnormal_lymphatic_system0.81534809
78MP0010630_abnormal_cardiac_muscle0.80682330
79MP0006035_abnormal_mitochondrial_morpho0.79808124
80MP0005220_abnormal_exocrine_pancreas0.79290109
81MP0005334_abnormal_fat_pad0.79192646
82MP0005266_abnormal_metabolism0.79125668
83MP0004270_analgesia0.78750731
84MP0005666_abnormal_adipose_tissue0.75516535
85MP0003137_abnormal_impulse_conducting0.74714675
86MP0005408_hypopigmentation0.74041821
87MP0009765_abnormal_xenobiotic_induced0.69313969
88MP0001661_extended_life_span0.69090538
89MP0003329_amyloid_beta_deposits0.67120549
90MP0004085_abnormal_heartbeat0.66168694
91MP0002638_abnormal_pupillary_reflex0.66157280
92MP0003646_muscle_fatigue0.63019373
93MP0005448_abnormal_energy_balance0.61616616
94MP0002136_abnormal_kidney_physiology0.61236542
95MP0004147_increased_porphyrin_level0.60989723
96MP0003950_abnormal_plasma_membrane0.60423283
97MP0005330_cardiomyopathy0.60338568
98MP0000230_abnormal_systemic_arterial0.59581433
99MP0002822_catalepsy0.56129249
100MP0001765_abnormal_ion_homeostasis0.55823101
101MP0005379_endocrine/exocrine_gland_phen0.54733951
102MP0003953_abnormal_hormone_level0.54243246
103MP0002090_abnormal_vision0.54086793
104MP0000733_abnormal_muscle_development0.53875192
105MP0002938_white_spotting0.53447315
106MP0005058_abnormal_lysosome_morphology0.52889110
107MP0010386_abnormal_urinary_bladder0.50196414
108MP0000639_abnormal_adrenal_gland0.49095668
109MP0002928_abnormal_bile_duct0.48236318
110MP0003638_abnormal_response/metabolism_0.47916821
111MP0001984_abnormal_olfaction0.47725204
112MP0003122_maternal_imprinting0.47155007
113MP0004510_myositis0.46015573
114MP0002269_muscular_atrophy0.45987898
115MP0003941_abnormal_skin_development0.45248184
116MP0000372_irregular_coat_pigmentation0.44799324
117MP0008874_decreased_physiological_sensi0.43665189
118MP0005395_other_phenotype0.42311199
119MP0004036_abnormal_muscle_relaxation0.39734226
120MP0003724_increased_susceptibility_to0.39463931
121MP0009115_abnormal_fat_cell0.39114631
122MP0004782_abnormal_surfactant_physiolog0.39074931
123MP0008872_abnormal_physiological_respon0.38202129
124MP0008873_increased_physiological_sensi0.36773049
125MP0003075_altered_response_to0.36440736
126MP0009053_abnormal_anal_canal0.36199500
127MP0005166_decreased_susceptibility_to0.35938306
128MP0005375_adipose_tissue_phenotype0.34644051
129MP0002168_other_aberrant_phenotype0.34573348
130MP0009384_cardiac_valve_regurgitation0.34525775
131MP0000579_abnormal_nail_morphology0.33203190
132MP0003959_abnormal_lean_body0.32657622
133MP0001944_abnormal_pancreas_morphology0.32517312
134* MP0003690_abnormal_glial_cell0.31757128
135MP0000538_abnormal_urinary_bladder0.30788257
136MP0003718_maternal_effect0.29775153
137* MP0002970_abnormal_white_adipose0.29090808
138MP0009672_abnormal_birth_weight0.29043378
139MP0002796_impaired_skin_barrier0.28975753
140MP0000249_abnormal_blood_vessel0.28230116
141MP0002332_abnormal_exercise_endurance0.28122475
142MP0005165_increased_susceptibility_to0.27887235
143MP0005464_abnormal_platelet_physiology0.27874737

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.51228500
2Nemaline bodies (HP:0003798)7.35845944
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.12094399
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.87630751
5Intrahepatic cholestasis (HP:0001406)6.64236331
6Deep venous thrombosis (HP:0002625)6.32840459
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.92809961
8Exercise-induced muscle cramps (HP:0003710)5.82160035
9Xanthomatosis (HP:0000991)5.78174690
10Exercise-induced myalgia (HP:0003738)5.70058693
11Prolonged partial thromboplastin time (HP:0003645)5.68579983
12Hypobetalipoproteinemia (HP:0003563)5.56942113
13Type 1 muscle fiber predominance (HP:0003803)5.32391851
14Hyperlipoproteinemia (HP:0010980)4.99459637
15Muscle hypertrophy of the lower extremities (HP:0008968)4.90372384
16Complement deficiency (HP:0004431)4.86846602
17Hyperammonemia (HP:0001987)4.75794550
18Ketosis (HP:0001946)4.67559232
19Hyperglycinemia (HP:0002154)4.52849934
20Hyperglycinuria (HP:0003108)4.51733840
21Calf muscle hypertrophy (HP:0008981)4.47369274
22Hypoglycemic coma (HP:0001325)4.43007487
23Hypolipoproteinemia (HP:0010981)4.32697521
24Abnormality of glycine metabolism (HP:0010895)4.29915993
25Abnormality of serine family amino acid metabolism (HP:0010894)4.29915993
26Rhabdomyolysis (HP:0003201)4.25272473
27Abnormality of glutamine family amino acid metabolism (HP:0010902)4.20258721
28Epidermoid cyst (HP:0200040)4.09895204
29Joint hemorrhage (HP:0005261)4.08874777
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.98995043
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.96424144
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.96385357
33Distal arthrogryposis (HP:0005684)3.92972198
34Abnormality of the common coagulation pathway (HP:0010990)3.91416838
35Hypoalphalipoproteinemia (HP:0003233)3.90880650
36EMG: myopathic abnormalities (HP:0003458)3.85774830
37Abnormality of methionine metabolism (HP:0010901)3.81081651
38Ketoacidosis (HP:0001993)3.80375615
39Fat malabsorption (HP:0002630)3.77025103
40* Abnormality of fatty-acid metabolism (HP:0004359)3.60140556
41Abnormality of the calf musculature (HP:0001430)3.59836806
42Myopathic facies (HP:0002058)3.53574854
43Conjugated hyperbilirubinemia (HP:0002908)3.53193760
44Abnormality of the intrinsic pathway (HP:0010989)3.51182460
45Abnormality of complement system (HP:0005339)3.46091542
46Hyporeflexia of lower limbs (HP:0002600)3.37663042
47Rimmed vacuoles (HP:0003805)3.27332252
48Muscle fiber splitting (HP:0003555)3.25244071
49Abnormality of pyrimidine metabolism (HP:0004353)3.25071231
50Dicarboxylic aciduria (HP:0003215)3.17829690
51Abnormality of dicarboxylic acid metabolism (HP:0010995)3.17829690
52Abnormality of serum amino acid levels (HP:0003112)3.16845545
53Round ear (HP:0100830)3.16333982
54Hypercholesterolemia (HP:0003124)3.15919523
55Gout (HP:0001997)3.15626757
56Hyperbilirubinemia (HP:0002904)3.15584417
57Abnormality of nucleobase metabolism (HP:0010932)3.09261787
58Metabolic acidosis (HP:0001942)3.08858125
59Asymmetric septal hypertrophy (HP:0001670)3.03488063
60Delayed CNS myelination (HP:0002188)3.03470208
61Abnormality of purine metabolism (HP:0004352)3.01357064
62Ulnar deviation of the wrist (HP:0003049)2.98185845
63Lethargy (HP:0001254)2.95977108
64Cerebral edema (HP:0002181)2.94100877
65Neck muscle weakness (HP:0000467)2.93488314
66* Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.92178327
67Generalized aminoaciduria (HP:0002909)2.83518258
68Steatorrhea (HP:0002570)2.78848359
69Skin nodule (HP:0200036)2.77014047
70Hypoglycemic seizures (HP:0002173)2.73794873
71Hepatocellular carcinoma (HP:0001402)2.69846124
72Sudden death (HP:0001699)2.67382080
73Centrally nucleated skeletal muscle fibers (HP:0003687)2.62844668
74Muscle stiffness (HP:0003552)2.62769934
75Bundle branch block (HP:0011710)2.62426453
76Increased serum pyruvate (HP:0003542)2.57169728
77Reduced antithrombin III activity (HP:0001976)2.56818622
78Difficulty running (HP:0009046)2.53533243
79Systemic lupus erythematosus (HP:0002725)2.52032424
80Vascular calcification (HP:0004934)2.51635632
81Abnormality of skeletal muscle fiber size (HP:0012084)2.51493391
82Absent phalangeal crease (HP:0006109)2.50537902
83Spontaneous abortion (HP:0005268)2.50389487
84Myocardial infarction (HP:0001658)2.49109815
85Abnormal gallbladder morphology (HP:0012437)2.47205100
86Distal lower limb muscle weakness (HP:0009053)2.46254954
87Abnormality of the left ventricular outflow tract (HP:0011103)2.45202284
88Subaortic stenosis (HP:0001682)2.45202284
89Hyperinsulinemic hypoglycemia (HP:0000825)2.44246100
90Abnormality of glycolysis (HP:0004366)2.42384943
91Vomiting (HP:0002013)2.41524359
92Cholelithiasis (HP:0001081)2.41023978
93Late onset (HP:0003584)2.39048453
94Proximal tubulopathy (HP:0000114)2.38488745
95Irritability (HP:0000737)2.38389563
96Hypochromic microcytic anemia (HP:0004840)2.36368903
97Neonatal onset (HP:0003623)2.35416314
98Acute necrotizing encephalopathy (HP:0006965)2.32389295
99Calcaneovalgus deformity (HP:0001848)2.30040832
100Malnutrition (HP:0004395)2.24916547
101Abnormal mitochondria in muscle tissue (HP:0008316)2.23932966
102Spastic diplegia (HP:0001264)2.23109424
103Cholecystitis (HP:0001082)2.22736088
104Abnormal gallbladder physiology (HP:0012438)2.22736088
105Pancreatitis (HP:0001733)2.21967843
106Cardiovascular calcification (HP:0011915)2.21721075
107Hyperuricemia (HP:0002149)2.19641474
108Increased purine levels (HP:0004368)2.19641474
109Dilated cardiomyopathy (HP:0001644)2.19596875
110Alkalosis (HP:0001948)2.19071696
111Glycosuria (HP:0003076)2.16727031
112Abnormality of urine glucose concentration (HP:0011016)2.16727031
113Myoglobinuria (HP:0002913)2.16706157
114Acanthocytosis (HP:0001927)2.15226530
115Enlarged kidneys (HP:0000105)2.14884806
116Exercise intolerance (HP:0003546)2.14078415
117Myotonia (HP:0002486)2.12059860
118Abnormality of proline metabolism (HP:0010907)2.11528629
119Hydroxyprolinuria (HP:0003080)2.11528629
120Renal cortical cysts (HP:0000803)2.10824133
121Heart block (HP:0012722)2.10662602
122Mitral stenosis (HP:0001718)2.09036507
123Deformed tarsal bones (HP:0008119)2.08763437
124Brushfield spots (HP:0001088)2.08480491
125Frequent falls (HP:0002359)2.08070911
126Increased variability in muscle fiber diameter (HP:0003557)2.07607280
127Increased connective tissue (HP:0009025)2.06853982
128Hyperglycemia (HP:0003074)2.06723155
129Recurrent gram-negative bacterial infections (HP:0005420)2.03980265
130Areflexia of lower limbs (HP:0002522)2.03057650
131Progressive macrocephaly (HP:0004481)2.00906302
132Glomerulonephritis (HP:0000099)2.00856688
133Hepatocellular necrosis (HP:0001404)1.97841972
134Abnormality of the gallbladder (HP:0005264)1.97822062
135Esophageal varix (HP:0002040)1.97570498
136EMG: neuropathic changes (HP:0003445)1.96879773
137Amyloidosis (HP:0011034)1.94725309
138Abnormal finger flexion creases (HP:0006143)1.94669087
139Symptomatic seizures (HP:0011145)1.93570250
140Abnormal atrioventricular conduction (HP:0005150)1.93426405
141Increased muscle lipid content (HP:0009058)1.91639219
142Malignant hyperthermia (HP:0002047)1.91199434
143Increased intramyocellular lipid droplets (HP:0012240)1.90558456
144Mitochondrial inheritance (HP:0001427)1.90466582
145Abnormal cartilage morphology (HP:0002763)1.89870138
146Opisthotonus (HP:0002179)1.88979765
147Hepatic necrosis (HP:0002605)1.87941528
148Rickets (HP:0002748)1.87671765
149Acute hepatic failure (HP:0006554)1.85373996
150Nausea (HP:0002018)1.83389165
151Acute encephalopathy (HP:0006846)1.82397937
152Abnormal enzyme/coenzyme activity (HP:0012379)1.82282000
153Abnormality of vitamin metabolism (HP:0100508)1.81034812
154Elevated hepatic transaminases (HP:0002910)1.79892586

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.54481776
2ERN13.94495865
3FGFR43.65210488
4SIK13.50202117
5INSRR3.30916824
6TAOK32.65432840
7ERBB42.38365292
8MAP2K42.02780313
9TRIB32.01746352
10PKN21.99463840
11MST1R1.88647746
12PDK31.85815396
13PDK41.85815396
14PINK11.81306621
15PIK3CG1.78246146
16FLT31.76322285
17LIMK11.65600046
18ERBB31.65036928
19FRK1.63559358
20MAPK111.60349077
21MUSK1.51097336
22STK38L1.50720336
23LATS11.49588057
24WNK41.38186181
25MAP3K71.34820773
26TYK21.30319562
27NEK91.28760318
28MAP3K121.26240936
29MYLK1.24865442
30PRKAA21.22871720
31PTK61.22851813
32MAPKAPK31.22177926
33DAPK21.19195900
34PDK21.19078545
35ABL21.16661188
36MAP3K31.11862530
37MAPK151.11506475
38JAK21.05717114
39TIE11.04451583
40MAP2K31.02419279
41OBSCN0.99949855
42CAMK2D0.98188168
43LMTK20.94594566
44KDR0.94265512
45STK160.94028330
46NME10.91892584
47WNK30.89545307
48JAK10.88594678
49PRKAA10.88386847
50FER0.87691978
51TRPM70.85683736
52TBK10.83034275
53MAPK120.82268996
54EPHB10.81581997
55CAMK2G0.81443148
56PHKG20.80586534
57PHKG10.80586534
58TTN0.79435068
59IRAK30.78854831
60ACVR1B0.77555276
61PRKACG0.77448260
62SGK30.76075844
63NEK10.75809649
64PRKG10.74414204
65AKT30.74297408
66FGFR20.74246337
67PIK3CA0.73751153
68GRK60.71912817
69TESK10.70724492
70MAPK40.69994944
71PDPK10.69781137
72PRKCZ0.69053846
73MET0.68293909
74ERBB20.67239183
75EPHA30.67134190
76MAP3K140.65025083
77MAP2K60.64878820
78SGK20.64642840
79EIF2AK30.64223569
80CAMK1D0.63889508
81MAP4K20.62971566
82SGK4940.62451596
83SGK2230.62451596
84PAK30.59717898
85CASK0.59144902
86GSK3A0.57929032
87RIPK10.57577042
88VRK20.56884169
89CAMK2A0.56603068
90MAP3K110.56249981
91CSNK1G10.55389929
92DMPK0.54864252
93CCNB10.54573284
94STK240.54156383
95PRKD30.51053561
96PRKCE0.50812005
97MST40.50067270
98TNIK0.49209981
99TRIM280.49095149
100AKT20.48121036
101TGFBR20.47952760
102MAP2K10.47644135
103FGFR30.47565437
104DYRK1B0.47126424
105MOS0.46068783
106PDK10.45906322
107OXSR10.45755832
108MAP3K50.44945282
109CAMK2B0.44777689
110PRKCQ0.44042149
111MAP3K20.44012609
112ROCK10.43963516
113MAPK70.43448831
114PTK20.42804995
115PRKACB0.42180560
116BCR0.41373799
117CSNK1G20.41066834
118EPHB20.41032574
119PBK0.40605219
120STK380.40479092
121IRAK10.39943001
122CSNK1G30.38920442
123CSK0.38238612
124EIF2AK10.38131429
125PKN10.37891342
126CAMK10.37476660
127MAP3K10.36454216
128CAMK40.36094179
129RPS6KA30.33267558
130IGF1R0.33242591
131RET0.32770521
132EPHA40.31245674
133PRKD10.31237020
134NLK0.30330184
135PRKCG0.30222698
136BMPR1B0.30077950
137CSNK1A10.29932881
138ARAF0.29784596
139MAP3K100.29172503
140PRKACA0.29096993
141IKBKE0.28812823
142MAPK130.28601682
143PRKCA0.27348344
144MARK10.26877898
145DAPK30.26719586
146IRAK20.25863157
147MAP2K20.25795630
148GRK10.24937671
149SGK10.24539325
150GRK70.22140502

Predicted pathways (KEGG)

RankGene SetZ-score
1Parkinsons disease_Homo sapiens_hsa050126.88921061
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.15287772
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.46456514
4Nitrogen metabolism_Homo sapiens_hsa009103.31855973
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15473330
6Arginine biosynthesis_Homo sapiens_hsa002202.91373835
7Fatty acid degradation_Homo sapiens_hsa000712.78018987
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74246593
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.70455927
10Tryptophan metabolism_Homo sapiens_hsa003802.69855401
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50676033
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.37633964
13Complement and coagulation cascades_Homo sapiens_hsa046102.36848142
14Propanoate metabolism_Homo sapiens_hsa006402.36465142
15Butanoate metabolism_Homo sapiens_hsa006502.35908272
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20119221
17* Peroxisome_Homo sapiens_hsa041462.09557287
18Fatty acid metabolism_Homo sapiens_hsa012122.02164610
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97839526
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96624576
21PPAR signaling pathway_Homo sapiens_hsa033201.90989691
22beta-Alanine metabolism_Homo sapiens_hsa004101.78526823
23Histidine metabolism_Homo sapiens_hsa003401.78007707
24Chemical carcinogenesis_Homo sapiens_hsa052041.74545234
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73335130
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72245121
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.70067022
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67994113
29Pyruvate metabolism_Homo sapiens_hsa006201.64385746
30Caffeine metabolism_Homo sapiens_hsa002321.61202379
31Sulfur metabolism_Homo sapiens_hsa009201.57697777
32Phenylalanine metabolism_Homo sapiens_hsa003601.56429975
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.55249509
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55189379
35Retinol metabolism_Homo sapiens_hsa008301.51488545
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47938990
37Selenocompound metabolism_Homo sapiens_hsa004501.45892153
38Bile secretion_Homo sapiens_hsa049761.44112418
39Fatty acid elongation_Homo sapiens_hsa000621.43056599
40Staphylococcus aureus infection_Homo sapiens_hsa051501.41843708
41Carbon metabolism_Homo sapiens_hsa012001.39922894
42Tyrosine metabolism_Homo sapiens_hsa003501.39579898
43Starch and sucrose metabolism_Homo sapiens_hsa005001.36950134
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34865659
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.26447135
46Biosynthesis of amino acids_Homo sapiens_hsa012301.23898263
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.17521137
48Folate biosynthesis_Homo sapiens_hsa007901.17483533
49Cardiac muscle contraction_Homo sapiens_hsa042601.14696260
50Fat digestion and absorption_Homo sapiens_hsa049751.14051739
51ABC transporters_Homo sapiens_hsa020101.10633855
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08865401
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01173116
54Arginine and proline metabolism_Homo sapiens_hsa003301.00623964
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.96612886
56Steroid biosynthesis_Homo sapiens_hsa001000.87508681
57Vitamin digestion and absorption_Homo sapiens_hsa049770.85201663
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84942489
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84932864
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84319998
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84142720
62Sulfur relay system_Homo sapiens_hsa041220.83825827
63Vitamin B6 metabolism_Homo sapiens_hsa007500.80663350
64Lysine degradation_Homo sapiens_hsa003100.80464065
65Circadian rhythm_Homo sapiens_hsa047100.78740114
66Glycerolipid metabolism_Homo sapiens_hsa005610.73637426
67Glutathione metabolism_Homo sapiens_hsa004800.66643562
68Dilated cardiomyopathy_Homo sapiens_hsa054140.62293740
69Pentose phosphate pathway_Homo sapiens_hsa000300.56829820
70Fatty acid biosynthesis_Homo sapiens_hsa000610.56619488
71Protein export_Homo sapiens_hsa030600.53514316
72Metabolic pathways_Homo sapiens_hsa011000.51296916
73One carbon pool by folate_Homo sapiens_hsa006700.46618399
74Fructose and mannose metabolism_Homo sapiens_hsa000510.39627666
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39383881
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38837658
77Huntingtons disease_Homo sapiens_hsa050160.37708252
78Galactose metabolism_Homo sapiens_hsa000520.35260257
79Prion diseases_Homo sapiens_hsa050200.32554965
80Insulin resistance_Homo sapiens_hsa049310.31590480
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.31094057
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26155911
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26018261
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25263598
85Glucagon signaling pathway_Homo sapiens_hsa049220.21155561
86Linoleic acid metabolism_Homo sapiens_hsa005910.20138093
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19033552
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.17676658
89Other glycan degradation_Homo sapiens_hsa005110.15665166
90Insulin secretion_Homo sapiens_hsa049110.12401706
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11835797
92Oxidative phosphorylation_Homo sapiens_hsa001900.09610475
93Proteasome_Homo sapiens_hsa030500.09605774
94AMPK signaling pathway_Homo sapiens_hsa041520.09335611
95Lysosome_Homo sapiens_hsa04142-0.1936603
96Mineral absorption_Homo sapiens_hsa04978-0.1932391
97Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1916986
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1873241
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1838203
100Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1753653
101Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1585543
102Renin-angiotensin system_Homo sapiens_hsa04614-0.1382365
103Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1334625
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1184060
105Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1183284
106Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1102269
107Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1094458
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0689854
109Alzheimers disease_Homo sapiens_hsa05010-0.0570621
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0382768
111Regulation of autophagy_Homo sapiens_hsa04140-0.0353945
112Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0154473
113Insulin signaling pathway_Homo sapiens_hsa04910-0.0099446

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