PHLDA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.91124306
2establishment of apical/basal cell polarity (GO:0035089)5.76788066
3embryonic process involved in female pregnancy (GO:0060136)5.62608960
4negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.20257758
5transcription from mitochondrial promoter (GO:0006390)5.14446971
6regulation of integrin activation (GO:0033623)5.00451705
7establishment of monopolar cell polarity (GO:0061162)4.89074430
8establishment or maintenance of monopolar cell polarity (GO:0061339)4.89074430
9protein heterotrimerization (GO:0070208)4.78144261
10proline metabolic process (GO:0006560)4.59331636
11positive regulation of protein homooligomerization (GO:0032464)4.38017962
12regulation of translational fidelity (GO:0006450)4.25776115
13apoptotic process involved in morphogenesis (GO:0060561)4.16070700
14regulation of protein homooligomerization (GO:0032462)4.11550897
15regulation of hippo signaling (GO:0035330)4.07045950
16regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.03231049
17mitotic G1 DNA damage checkpoint (GO:0031571)3.93797147
18negative regulation of chondrocyte differentiation (GO:0032331)3.93635923
19embryonic camera-type eye development (GO:0031076)3.92570142
20cell migration involved in heart development (GO:0060973)3.91584601
21regulation of posttranscriptional gene silencing (GO:0060147)3.87353344
22regulation of gene silencing by miRNA (GO:0060964)3.87353344
23regulation of gene silencing by RNA (GO:0060966)3.87353344
24polarized epithelial cell differentiation (GO:0030859)3.87297090
25embryonic placenta development (GO:0001892)3.85680476
26formation of translation preinitiation complex (GO:0001731)3.68754805
27replication fork processing (GO:0031297)3.67604457
28barbed-end actin filament capping (GO:0051016)3.66747729
29oxidative demethylation (GO:0070989)3.63100652
30negative regulation of cartilage development (GO:0061037)3.60629798
31mitochondrial DNA metabolic process (GO:0032042)3.58584776
32adhesion of symbiont to host cell (GO:0044650)3.58389239
33virion attachment to host cell (GO:0019062)3.58389239
34negative regulation of JAK-STAT cascade (GO:0046426)3.57559929
35positive regulation of protein oligomerization (GO:0032461)3.56066486
36desmosome organization (GO:0002934)3.55297402
37glial cell migration (GO:0008347)3.54571544
38focal adhesion assembly (GO:0048041)3.53380739
39cell-substrate adherens junction assembly (GO:0007045)3.53380739
40protein localization to endosome (GO:0036010)3.50511799
41mitotic G1/S transition checkpoint (GO:0044819)3.49814902
42tooth mineralization (GO:0034505)3.47509487
43regulation of tight junction assembly (GO:2000810)3.46688324
44negative regulation of cell cycle arrest (GO:0071157)3.43438285
45dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.41358313
46kidney mesenchyme development (GO:0072074)3.41208975
47nodal signaling pathway (GO:0038092)3.40131889
48anatomical structure regression (GO:0060033)3.37390450
49negative regulation of focal adhesion assembly (GO:0051895)3.33010351
50negative regulation of cell junction assembly (GO:1901889)3.33010351
51negative regulation of adherens junction organization (GO:1903392)3.33010351
52regulation of early endosome to late endosome transport (GO:2000641)3.31681229
53G1 DNA damage checkpoint (GO:0044783)3.30661548
54peptidyl-proline hydroxylation (GO:0019511)3.29651207
55bone trabecula formation (GO:0060346)3.29515426
56DNA deamination (GO:0045006)3.28683372
57adhesion of symbiont to host (GO:0044406)3.27485865
58vascular endothelial growth factor signaling pathway (GO:0038084)3.27048898
59apoptotic process involved in development (GO:1902742)3.22951361
60anterior/posterior axis specification, embryo (GO:0008595)3.17571237
61regulation of apoptotic process involved in morphogenesis (GO:1902337)3.16167086
62stress fiber assembly (GO:0043149)3.15419758
63type B pancreatic cell proliferation (GO:0044342)3.14195992
64endothelial cell morphogenesis (GO:0001886)3.14130553
65convergent extension (GO:0060026)3.08593075
66endothelial cell chemotaxis (GO:0035767)3.04768420
67negative regulation of Ras GTPase activity (GO:0034261)3.04616702
68vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.04028365
69semaphorin-plexin signaling pathway (GO:0071526)3.03955468
70cellular response to vitamin (GO:0071295)3.03300451
71negative regulation of fatty acid biosynthetic process (GO:0045717)3.01796723
72basement membrane organization (GO:0071711)2.98797244
73epithelial cell-cell adhesion (GO:0090136)2.97107835
74regulation of protein oligomerization (GO:0032459)2.97073613
75extracellular matrix assembly (GO:0085029)2.96568760
76trophectodermal cell differentiation (GO:0001829)2.95592986
77atrioventricular valve morphogenesis (GO:0003181)2.95441491
78positive regulation of developmental pigmentation (GO:0048087)2.95404499
79regulation of glomerular filtration (GO:0003093)2.90742650
80plasma membrane repair (GO:0001778)2.89288946
81apoptotic cell clearance (GO:0043277)2.88413892
82endodermal cell differentiation (GO:0035987)2.88078112
83hemidesmosome assembly (GO:0031581)2.87021342
84labyrinthine layer development (GO:0060711)2.86755368
85collagen fibril organization (GO:0030199)2.86089269
86nuclear envelope reassembly (GO:0031468)2.84076856
87mitotic nuclear envelope reassembly (GO:0007084)2.84076856
88adherens junction assembly (GO:0034333)2.83698128
89metanephric mesenchyme development (GO:0072075)2.82904997
90cellular response to ATP (GO:0071318)2.82097885
91paraxial mesoderm development (GO:0048339)2.82002704
92collagen metabolic process (GO:0032963)2.81848870
93Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.81408468
94maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80970959
95protein hydroxylation (GO:0018126)2.78640149
96neuron projection extension involved in neuron projection guidance (GO:1902284)2.76791273
97axon extension involved in axon guidance (GO:0048846)2.76791273
98maternal placenta development (GO:0001893)2.75446411
99cell-substrate junction assembly (GO:0007044)2.75396930
100cochlea morphogenesis (GO:0090103)2.74532406
101hypotonic response (GO:0006971)2.73473079
102hippo signaling (GO:0035329)2.73025671
103regulation of SMAD protein import into nucleus (GO:0060390)2.72312006
104collagen catabolic process (GO:0030574)2.71414722
105regulation of integrin-mediated signaling pathway (GO:2001044)2.71292743
106heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.69853860
107protein retention in ER lumen (GO:0006621)2.69288025
108renal filtration (GO:0097205)2.68409751
109somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67063820
110somatic hypermutation of immunoglobulin genes (GO:0016446)2.67063820
111low-density lipoprotein particle clearance (GO:0034383)2.66589228
112chondrocyte proliferation (GO:0035988)2.66469374
113spliceosomal tri-snRNP complex assembly (GO:0000244)2.64473812
114positive regulation of SMAD protein import into nucleus (GO:0060391)2.64064003
115extracellular matrix disassembly (GO:0022617)2.63966025
116cell adhesion mediated by integrin (GO:0033627)2.63470265
117positive regulation of blood vessel endothelial cell migration (GO:0043536)2.62984464
118muscle cell migration (GO:0014812)2.62886352
119negative regulation of fatty acid transport (GO:2000192)2.61426699
120branching involved in mammary gland duct morphogenesis (GO:0060444)2.61283041
121establishment or maintenance of bipolar cell polarity (GO:0061245)2.61212575
122establishment or maintenance of apical/basal cell polarity (GO:0035088)2.61212575
123dermatan sulfate metabolic process (GO:0030205)2.60694523
124heterochromatin organization (GO:0070828)2.60144024
125regulation of cell size (GO:0008361)2.60097673
126regulation of establishment of planar polarity (GO:0090175)2.58796972
127negative regulation of smooth muscle cell migration (GO:0014912)2.58431762
128planar cell polarity pathway involved in neural tube closure (GO:0090179)2.57133176
129substrate adhesion-dependent cell spreading (GO:0034446)2.57113626
130multicellular organismal macromolecule metabolic process (GO:0044259)2.56204467
131glomerular basement membrane development (GO:0032836)2.55837204
132extracellular fibril organization (GO:0043206)2.54871232
133L-serine transport (GO:0015825)2.54696312
134negative regulation of protein oligomerization (GO:0032460)2.54278641
135skin morphogenesis (GO:0043589)2.52602580
136establishment of tissue polarity (GO:0007164)2.50684458
137establishment of planar polarity (GO:0001736)2.50684458
138endocardial cushion development (GO:0003197)2.50498739
139positive regulation of fatty acid beta-oxidation (GO:0032000)2.50475082
140COPI coating of Golgi vesicle (GO:0048205)2.49869839
141Golgi transport vesicle coating (GO:0048200)2.49869839
142dermatan sulfate biosynthetic process (GO:0030208)2.49100809
143regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.49074783
144bone morphogenesis (GO:0060349)2.48049805
145regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.48014212
146cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.47783204
147mitochondrial fusion (GO:0008053)2.46899301
148heparan sulfate proteoglycan metabolic process (GO:0030201)2.45911181
149non-canonical Wnt signaling pathway (GO:0035567)2.44079907
150labyrinthine layer blood vessel development (GO:0060716)2.43343313
151negative regulation of anoikis (GO:2000811)2.42702171
152negative regulation of tumor necrosis factor production (GO:0032720)2.41973039
153negative regulation of catenin import into nucleus (GO:0035414)2.41908399
154regulation of podosome assembly (GO:0071801)2.41314917
155multicellular organismal metabolic process (GO:0044236)2.40520341
156retina vasculature morphogenesis in camera-type eye (GO:0061299)2.40279319
157multicellular organismal catabolic process (GO:0044243)2.39333961
158maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.38825241
159cytoskeletal anchoring at plasma membrane (GO:0007016)2.37837704
160embryo implantation (GO:0007566)2.37693021
161sequestering of extracellular ligand from receptor (GO:0035581)2.36856949
162extracellular matrix organization (GO:0030198)2.36644670
163endocytic recycling (GO:0032456)2.36465348
164cellular response to nutrient (GO:0031670)2.35786332
165positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.35698594
166extracellular structure organization (GO:0043062)2.35564268
167serine transport (GO:0032329)2.34471983
168regulation of fatty acid beta-oxidation (GO:0031998)2.34249241
169negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.33375630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.92858567
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.02678304
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.00004801
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.95968158
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.95968158
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.95968158
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.92475325
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.88636332
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.58844140
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.57560028
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.57155878
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.37712815
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19985587
14KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.17764867
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.17728690
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.10397185
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09775098
18ESR1_21235772_ChIP-Seq_MCF-7_Human1.98389950
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.98362004
20TCF3_18692474_ChIP-Seq_MEFs_Mouse1.96696219
21STAT3_1855785_ChIP-Seq_MESCs_Mouse1.95500449
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.94025248
23LXR_22292898_ChIP-Seq_THP-1_Human1.92874592
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88775269
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.87046657
26ZNF263_19887448_ChIP-Seq_K562_Human1.86601019
27* RACK7_27058665_Chip-Seq_MCF-7_Human1.86118620
28* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.85686335
29* MYC_18555785_ChIP-Seq_MESCs_Mouse1.83430486
30* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81959631
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.78793596
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77892627
33NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.77061831
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76569397
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75243209
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.73875527
37VDR_21846776_ChIP-Seq_THP-1_Human1.72424670
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71114277
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71093209
40TCF3_18692474_ChIP-Seq_MESCs_Mouse1.69029407
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67744661
42CLOCK_20551151_ChIP-Seq_293T_Human1.63629130
43* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62159028
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62032164
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59799761
46POU5F1_16518401_ChIP-PET_MESCs_Mouse1.59455999
47ATF3_27146783_Chip-Seq_COLON_Human1.57933398
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57013722
49* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56181125
50* TP53_20018659_ChIP-ChIP_R1E_Mouse1.47156130
51* UBF1/2_26484160_Chip-Seq_HMECs_Human1.46044750
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.45122417
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.44652475
54* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43812747
55SMC3_22415368_ChIP-Seq_MEFs_Mouse1.41643453
56* KDM2B_26808549_Chip-Seq_DND41_Human1.40078399
57* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40042562
58NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.39697485
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38970135
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38894382
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38512360
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38221947
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37713135
64* CTCF_27219007_Chip-Seq_Bcells_Human1.37176418
65* TP53_22127205_ChIP-Seq_IMR90_Human1.35768357
66TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35320361
67* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34810090
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.33285849
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32491635
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32491635
71TET1_21490601_ChIP-Seq_MESCs_Mouse1.32371743
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.32331413
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32321754
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.32188369
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29423774
76SMC1_22415368_ChIP-Seq_MEFs_Mouse1.29083466
77EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.27935973
78EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27765709
79RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27765709
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27717100
81SOX2_18692474_ChIP-Seq_MEFs_Mouse1.27446871
82* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26178333
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25420615
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.25102613
85MYC_22102868_ChIP-Seq_BL_Human1.23516047
86* TP53_23651856_ChIP-Seq_MEFs_Mouse1.23365195
87* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22401962
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21952848
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21355592
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20788872
91* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20516133
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19824219
93* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19268882
94* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18053624
95* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17831623
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17088590
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16120663
98FOXM1_23109430_ChIP-Seq_U2OS_Human1.15082563
99SMC4_20622854_ChIP-Seq_HELA_Human1.13336495
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12061814
101* KDM2B_26808549_Chip-Seq_K562_Human1.11963147
102* TET1_21451524_ChIP-Seq_MESCs_Mouse1.11711069
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10951800
104MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10855945
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10621729
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10351121
107TBX20_22328084_ChIP-Seq_HEART_Mouse1.09569435
108TBX20_22080862_ChIP-Seq_HEART_Mouse1.09569435
109TP63_22573176_ChIP-Seq_HFKS_Human1.09262480
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08268191
111NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08183315
112MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07102475
113NANOG_18692474_ChIP-Seq_MESCs_Mouse1.06351159
114JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05991153
115SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04704250
116TFEB_21752829_ChIP-Seq_HELA_Human1.02920320
117* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02895497
118PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.02570429
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01603284
120* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.01211114
121TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00739984
122SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00244640
123NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99713273
124SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99520004
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99515161
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99395682
127CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99279670
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99094206
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98653893
130CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98492529
131SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98486142
132* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98459955
133SA1_22415368_ChIP-Seq_MEFs_Mouse0.97601100
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97080024
135* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96953024
136CREB1_26743006_Chip-Seq_LNCaP_Human0.96041244
137SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94681008
138PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94338041
139SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.93743500
140EZH2_27294783_Chip-Seq_ESCs_Mouse0.93411152
141KDM2B_26808549_Chip-Seq_JURKAT_Human0.93302230
142P68_20966046_ChIP-Seq_HELA_Human0.92821683
143NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92354996
144CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92153056
145POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92010833
146SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91774899
147ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91588825

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.75205089
2MP0003705_abnormal_hypodermis_morpholog3.84074196
3MP0010030_abnormal_orbit_morphology3.80873789
4MP0005275_abnormal_skin_tensile3.16712558
5MP0005257_abnormal_intraocular_pressure3.02411421
6MP0010352_gastrointestinal_tract_polyps2.61667436
7MP0004233_abnormal_muscle_weight2.61507111
8MP0005623_abnormal_meninges_morphology2.45160112
9MP0005171_absent_coat_pigmentation2.33360622
10MP0009278_abnormal_bone_marrow2.32352955
11MP0009384_cardiac_valve_regurgitation2.19973003
12MP0003566_abnormal_cell_adhesion2.18830129
13MP0003283_abnormal_digestive_organ2.01143848
14MP0003279_aneurysm2.00979680
15MP0004272_abnormal_basement_membrane1.92698274
16MP0002060_abnormal_skin_morphology1.87941831
17MP0004185_abnormal_adipocyte_glucose1.87331262
18MP0005503_abnormal_tendon_morphology1.78909063
19MP0005023_abnormal_wound_healing1.78664841
20MP0000733_abnormal_muscle_development1.78321355
21MP0003453_abnormal_keratinocyte_physiol1.75998893
22MP0005076_abnormal_cell_differentiation1.75806521
23MP0008057_abnormal_DNA_replication1.73300918
24MP0009840_abnormal_foam_cell1.73010739
25MP0004858_abnormal_nervous_system1.70544274
26MP0005508_abnormal_skeleton_morphology1.64818518
27MP0004133_heterotaxia1.64585081
28MP0002269_muscular_atrophy1.57384325
29MP0000767_abnormal_smooth_muscle1.57157024
30MP0002796_impaired_skin_barrier1.56318371
31MP0005670_abnormal_white_adipose1.53967579
32MP0005058_abnormal_lysosome_morphology1.52491862
33MP0000751_myopathy1.52480528
34MP0000750_abnormal_muscle_regeneration1.51853016
35MP0002249_abnormal_larynx_morphology1.50396999
36MP0005666_abnormal_adipose_tissue1.45605609
37MP0000762_abnormal_tongue_morphology1.44369146
38MP0009780_abnormal_chondrocyte_physiolo1.43271685
39MP0000759_abnormal_skeletal_muscle1.42634144
40MP0003091_abnormal_cell_migration1.40268581
41MP0001958_emphysema1.39948432
42MP0010368_abnormal_lymphatic_system1.39130190
43MP0001348_abnormal_lacrimal_gland1.37273619
44MP0002653_abnormal_ependyma_morphology1.36509484
45MP0004197_abnormal_fetal_growth/weight/1.36449373
46MP0002089_abnormal_postnatal_growth/wei1.36263213
47MP0002282_abnormal_trachea_morphology1.35460194
48MP0002108_abnormal_muscle_morphology1.35302530
49MP0003385_abnormal_body_wall1.33116944
50MP0003045_fibrosis1.31998766
51MP0003119_abnormal_digestive_system1.30887549
52MP0005501_abnormal_skin_physiology1.30239143
53MP0005375_adipose_tissue_phenotype1.28728528
54MP0002896_abnormal_bone_mineralization1.28592415
55MP0005595_abnormal_vascular_smooth1.28321090
56MP0004087_abnormal_muscle_fiber1.28280334
57MP0002111_abnormal_tail_morphology1.25855822
58MP0002932_abnormal_joint_morphology1.24523097
59MP0002084_abnormal_developmental_patter1.22662838
60MP0003755_abnormal_palate_morphology1.21929957
61MP0000534_abnormal_ureter_morphology1.19496861
62MP0005451_abnormal_body_composition1.17470988
63MP0001849_ear_inflammation1.16251640
64MP0002086_abnormal_extraembryonic_tissu1.16211570
65MP0000747_muscle_weakness1.15890094
66MP0000749_muscle_degeneration1.15438319
67MP0000013_abnormal_adipose_tissue1.14961607
68MP0009379_abnormal_foot_pigmentation1.14873568
69MP0002085_abnormal_embryonic_tissue1.14565687
70MP0000003_abnormal_adipose_tissue1.14428068
71MP0003941_abnormal_skin_development1.14323321
72MP0001299_abnormal_eye_distance/1.12286366
73MP0010771_integument_phenotype1.10466810
74MP0004130_abnormal_muscle_cell1.10290875
75MP0002877_abnormal_melanocyte_morpholog1.09151028
76MP0009053_abnormal_anal_canal1.08294131
77MP0005397_hematopoietic_system_phenotyp1.07997610
78MP0001545_abnormal_hematopoietic_system1.07997610
79MP0009115_abnormal_fat_cell1.07663332
80MP0001243_abnormal_dermal_layer1.07219819
81MP0001697_abnormal_embryo_size1.07148202
82MP0009250_abnormal_appendicular_skeleto1.06099546
83MP0005330_cardiomyopathy1.05537697
84MP0004957_abnormal_blastocyst_morpholog1.05397656
85MP0000462_abnormal_digestive_system1.04224298
86MP0006138_congestive_heart_failure1.01563470
87MP0002295_abnormal_pulmonary_circulatio1.01455439
88MP0002009_preneoplasia1.01432333
89MP0000579_abnormal_nail_morphology1.01254050
90MP0000467_abnormal_esophagus_morphology0.99633940
91MP0003329_amyloid_beta_deposits0.99122159
92MP0003890_abnormal_embryonic-extraembry0.97486746
93MP0005380_embryogenesis_phenotype0.97129819
94MP0001672_abnormal_embryogenesis/_devel0.97129819
95MP0002114_abnormal_axial_skeleton0.95749066
96MP0003191_abnormal_cellular_cholesterol0.95008372
97MP0002332_abnormal_exercise_endurance0.94479001
98MP0001730_embryonic_growth_arrest0.93468348
99MP0000049_abnormal_middle_ear0.93465007
100MP0002106_abnormal_muscle_physiology0.93209006
101MP0010630_abnormal_cardiac_muscle0.93023116
102MP0000432_abnormal_head_morphology0.92970113
103MP0003950_abnormal_plasma_membrane0.92706126
104MP0001216_abnormal_epidermal_layer0.92251528
105MP0003828_pulmonary_edema0.92198250
106MP0005369_muscle_phenotype0.91899100
107MP0000350_abnormal_cell_proliferation0.91873630
108MP0003942_abnormal_urinary_system0.91768732
109MP0005409_darkened_coat_color0.90821535
110MP0008932_abnormal_embryonic_tissue0.90648533
111MP0000516_abnormal_urinary_system0.90261233
112MP0005367_renal/urinary_system_phenotyp0.90261233
113MP0003935_abnormal_craniofacial_develop0.90217015
114MP0004134_abnormal_chest_morphology0.89924390
115MP0001293_anophthalmia0.89844980
116MP0000678_abnormal_parathyroid_gland0.89844125
117MP0000428_abnormal_craniofacial_morphol0.87671479
118MP0000163_abnormal_cartilage_morphology0.87094884
119MP0002971_abnormal_brown_adipose0.85919702
120MP0003984_embryonic_growth_retardation0.85653643
121MP0001340_abnormal_eyelid_morphology0.85312544
122MP0000343_altered_response_to0.84052689
123MP0002088_abnormal_embryonic_growth/wei0.83171086
124MP0001542_abnormal_bone_strength0.83074095
125MP0002970_abnormal_white_adipose0.82401687
126MP0002116_abnormal_craniofacial_bone0.82212255
127MP0010307_abnormal_tumor_latency0.80733695
128MP0000858_altered_metastatic_potential0.80384301
129MP0001879_abnormal_lymphatic_vessel0.80333363
130MP0010234_abnormal_vibrissa_follicle0.77244652
131MP0003959_abnormal_lean_body0.77110274
132MP0001661_extended_life_span0.76688165
133MP0005390_skeleton_phenotype0.75464235
134MP0002098_abnormal_vibrissa_morphology0.74955375
135MP0002254_reproductive_system_inflammat0.74722017
136MP0003634_abnormal_glial_cell0.74564726
137MP0008260_abnormal_autophagy0.74201838
138MP0000537_abnormal_urethra_morphology0.71781463
139MP0005197_abnormal_uvea_morphology0.71764222
140MP0002234_abnormal_pharynx_morphology0.66713402
141MP0005193_abnormal_anterior_eye0.66574628
142MP0002113_abnormal_skeleton_development0.65845731
143MP0005165_increased_susceptibility_to0.64206773
144MP0000538_abnormal_urinary_bladder0.63718760
145MP0003186_abnormal_redox_activity0.62372253
146MP0001614_abnormal_blood_vessel0.62228226

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.30393997
2Premature rupture of membranes (HP:0001788)5.15157865
3Cerebral aneurysm (HP:0004944)4.29428868
4Ulnar bowing (HP:0003031)3.95955033
5Turricephaly (HP:0000262)3.59555743
6Type 1 muscle fiber predominance (HP:0003803)3.49179771
7Increased connective tissue (HP:0009025)3.48146729
8Round ear (HP:0100830)3.42578215
9Coronal craniosynostosis (HP:0004440)3.40906354
10Rib fusion (HP:0000902)3.36946519
11Shallow orbits (HP:0000586)3.36838243
12Alopecia of scalp (HP:0002293)3.24309142
13Vascular tortuosity (HP:0004948)3.24163397
14Concave nail (HP:0001598)3.17746628
15Follicular hyperkeratosis (HP:0007502)3.16983876
16Spinal rigidity (HP:0003306)2.97395564
17Ankle contracture (HP:0006466)2.95672700
18Distal lower limb muscle weakness (HP:0009053)2.92788099
19Short humerus (HP:0005792)2.92065519
20Calcaneovalgus deformity (HP:0001848)2.91071082
21Difficulty climbing stairs (HP:0003551)2.90362217
22Atrophic scars (HP:0001075)2.87797933
23Arterial tortuosity (HP:0005116)2.87063735
24Vertebral hypoplasia (HP:0008417)2.80374405
25Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.80374405
26Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.77907674
27Abnormal hemoglobin (HP:0011902)2.76820110
28Aplasia/hypoplasia of the humerus (HP:0006507)2.73762511
29Muscle fiber inclusion bodies (HP:0100299)2.72036879
30Congenital hip dislocation (HP:0001374)2.70686732
31Difficulty running (HP:0009046)2.70516123
32Fragile skin (HP:0001030)2.67438266
33Genu recurvatum (HP:0002816)2.66550575
34Abnormality of the calcaneus (HP:0008364)2.66084587
35Bowed forearm bones (HP:0003956)2.66007456
36Bowing of the arm (HP:0006488)2.66007456
37Deformed tarsal bones (HP:0008119)2.65098954
38Natal tooth (HP:0000695)2.63289479
39Selective tooth agenesis (HP:0001592)2.59667917
40Neonatal short-limb short stature (HP:0008921)2.57575944
41Short nail (HP:0001799)2.57445692
42Hyperacusis (HP:0010780)2.52983315
43Mitral regurgitation (HP:0001653)2.50294174
44Peritonitis (HP:0002586)2.46969874
45Blue sclerae (HP:0000592)2.46693383
46Nemaline bodies (HP:0003798)2.44652715
47Annular pancreas (HP:0001734)2.42476518
48Muscle fiber splitting (HP:0003555)2.41380408
49Joint stiffness (HP:0001387)2.40823491
50Slender build (HP:0001533)2.40237877
51Hyporeflexia of lower limbs (HP:0002600)2.39311314
52Generalized amyotrophy (HP:0003700)2.38383348
53Soft skin (HP:0000977)2.38294072
54Vertebral compression fractures (HP:0002953)2.38067751
55Distal arthrogryposis (HP:0005684)2.37910937
56Exercise-induced myalgia (HP:0003738)2.33358527
57Cervical subluxation (HP:0003308)2.32394444
58Broad metatarsal (HP:0001783)2.31583376
59Muscle fibrillation (HP:0010546)2.29186667
60Bowel diverticulosis (HP:0005222)2.29078850
61Aortic dissection (HP:0002647)2.28573233
62Distal upper limb amyotrophy (HP:0007149)2.27860335
63Upper limb amyotrophy (HP:0009129)2.27860335
64Biconcave vertebral bodies (HP:0004586)2.27839361
65Mildly elevated creatine phosphokinase (HP:0008180)2.27477737
66Elbow flexion contracture (HP:0002987)2.25201483
67Rectal fistula (HP:0100590)2.22799138
68Rectovaginal fistula (HP:0000143)2.22799138
69Increased variability in muscle fiber diameter (HP:0003557)2.22336958
70Hypercortisolism (HP:0001578)2.21421883
71Bladder diverticulum (HP:0000015)2.20155696
72Achilles tendon contracture (HP:0001771)2.19713506
73Stridor (HP:0010307)2.17302781
74Ulnar deviation of the wrist (HP:0003049)2.16243660
75Trismus (HP:0000211)2.15484845
76Hypoventilation (HP:0002791)2.13480013
77Diaphragmatic weakness (HP:0009113)2.12207886
78Abnormality of skeletal muscle fiber size (HP:0012084)2.11482279
79Pterygium (HP:0001059)2.11021181
80Myopathic facies (HP:0002058)2.10641676
81Distal lower limb amyotrophy (HP:0008944)2.09903885
82Long toe (HP:0010511)2.09599825
83Aortic regurgitation (HP:0001659)2.08333574
84Dilatation of the ascending aorta (HP:0005111)2.07143051
85Facial hemangioma (HP:0000329)2.06910228
86Acanthosis nigricans (HP:0000956)2.06267576
87Hypotrichosis (HP:0001006)2.06194159
88Aortic aneurysm (HP:0004942)2.06048954
89Alacrima (HP:0000522)2.05792472
90Neck muscle weakness (HP:0000467)2.05174481
91Hyperextensible skin (HP:0000974)2.04987469
92Abnormality of dentin (HP:0010299)2.04795002
93Vaginal fistula (HP:0004320)2.04601739
94Axonal loss (HP:0003447)2.04144555
95Premature skin wrinkling (HP:0100678)2.02696847
96Wrist flexion contracture (HP:0001239)2.02194854
97Spondylolisthesis (HP:0003302)2.01898126
98Wormian bones (HP:0002645)2.01523882
99Fragile nails (HP:0001808)1.99487667
100Milia (HP:0001056)1.99064110
101Tongue fasciculations (HP:0001308)1.98868212
102Vertebral fusion (HP:0002948)1.96146921
103Thin ribs (HP:0000883)1.95354150
104Joint laxity (HP:0001388)1.95066452
105Infantile muscular hypotonia (HP:0008947)1.93576409
106Scapular winging (HP:0003691)1.92073655
107Pustule (HP:0200039)1.91886269
108Renal duplication (HP:0000075)1.90544474
109Deviation of the hallux (HP:0010051)1.90279084
110Breech presentation (HP:0001623)1.90251302
111Congenital glaucoma (HP:0001087)1.89592157
112Spinal cord compression (HP:0002176)1.87256040
113Hallux valgus (HP:0001822)1.86705368
114Entropion (HP:0000621)1.86655637
115Thin bony cortex (HP:0002753)1.85906665
116Fused cervical vertebrae (HP:0002949)1.85783982
117Aneurysm (HP:0002617)1.84674046
118Abnormality of the Achilles tendon (HP:0005109)1.84485246
119Advanced eruption of teeth (HP:0006288)1.84028506
120Osteolytic defects of the phalanges of the hand (HP:0009771)1.83727976
121Osteolytic defects of the hand bones (HP:0009699)1.83727976
122Abnormality of the aortic arch (HP:0012303)1.83082529
123Intestinal fistula (HP:0100819)1.82420598
124Coxa vara (HP:0002812)1.82251249
125Hypoplastic ischia (HP:0003175)1.80382584
126Aortic valve stenosis (HP:0001650)1.80061970
127Mitral stenosis (HP:0001718)1.80026400
128Knee flexion contracture (HP:0006380)1.79944532
129Gastrointestinal dysmotility (HP:0002579)1.78494711
130Back pain (HP:0003418)1.77930994
131Hyperparathyroidism (HP:0000843)1.77698200
132Hand muscle atrophy (HP:0009130)1.77337692
133Asymmetric septal hypertrophy (HP:0001670)1.76907579
134Muscle stiffness (HP:0003552)1.76282483
135Insomnia (HP:0100785)1.75790658
136Abnormality of the acetabulum (HP:0003170)1.75561739
137Aplasia of the musculature (HP:0100854)1.73387179
138J-shaped sella turcica (HP:0002680)1.72682092
139Male infertility (HP:0003251)1.72538081
140Mitral valve prolapse (HP:0001634)1.72179770
141Ovoid vertebral bodies (HP:0003300)1.71691568
142Ectopia lentis (HP:0001083)1.71161526
143Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.70977199
144Disproportionate tall stature (HP:0001519)1.66405944
145Abnormality of nail color (HP:0100643)1.64969668
146Buphthalmos (HP:0000557)1.64288224
147Reduced subcutaneous adipose tissue (HP:0003758)1.63384433
148Abnormality of glycolipid metabolism (HP:0010969)1.63153228
149Abnormality of glycosphingolipid metabolism (HP:0004343)1.63153228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.31965130
2ICK4.33330315
3TRIB33.27731449
4LATS22.91466379
5PDGFRA2.77474168
6MAP3K112.76354381
7MAP3K62.74951621
8PIM22.60558628
9MYLK2.58199237
10BMX2.54775599
11TYRO32.54171078
12EPHA22.44595466
13MAPK152.28190243
14TTN2.24351936
15NTRK12.15052716
16SMG11.94724651
17FGR1.88844537
18MATK1.83086505
19IRAK31.81341349
20TRPM71.76141950
21ABL21.73446954
22PRKD21.69395923
23ARAF1.66957451
24DYRK1B1.64230532
25PINK11.61052293
26MUSK1.46571806
27CDK61.39666594
28LMTK21.38884814
29PHKG21.37715559
30PHKG11.37715559
31MST1R1.36475403
32CSK1.26016277
33ERN11.23212296
34RIPK11.21021934
35CDK71.19762200
36SIK11.16585371
37LATS11.16186724
38MTOR1.15793095
39PAK21.15742810
40PTK21.15076949
41UHMK11.12334029
42STK381.11389769
43MAPKAPK31.11368454
44TGFBR21.09871053
45CDK121.07838602
46PAK41.07432144
47RPS6KA21.07228905
48MAP3K101.03732565
49LIMK11.02055392
50NEK91.01817648
51MET0.94299082
52GSK3A0.92754759
53PKN20.91939282
54TESK20.90888317
55DAPK10.89823250
56RPS6KB20.88617992
57MAP3K90.83919962
58PIM10.83173504
59TESK10.82665002
60NEK10.81713105
61ERBB40.81255612
62CDC42BPA0.80917069
63TAOK20.78487517
64PRPF4B0.77308358
65ROCK20.76232640
66MAP3K30.75710768
67FLT30.75484356
68MOS0.75456087
69DMPK0.75077220
70PTK60.73560788
71ILK0.71818038
72EPHB20.71783946
73PRKG20.69755008
74CAMK1D0.69380771
75ROCK10.69352129
76PDPK10.67912846
77RPS6KC10.67855776
78RPS6KL10.67855776
79DYRK30.66464045
80LRRK20.66012718
81FER0.64954366
82FGFR10.64299478
83TAOK10.63762842
84PDGFRB0.63556428
85PAK10.63323740
86MAPK110.61340133
87BRAF0.60012423
88SCYL20.59637560
89RPS6KA60.58932211
90ADRBK10.58841407
91KSR20.58430111
92GRK50.56953653
93STK30.55554501
94MAP2K30.54251615
95CAMK2B0.54122333
96DAPK30.53933850
97PAK60.50818091
98EEF2K0.50728238
99PRKD10.50704494
100CHEK20.50572379
101MAPK40.49194411
102YES10.48964066
103PLK10.48758367
104STK100.48254838
105TGFBR10.47476081
106MAP2K10.47401056
107PDK30.46703233
108PDK40.46703233
109INSR0.45834903
110MAP3K80.45769731
111ALK0.45090118
112MARK20.44977355
113PRKD30.43666425
114RPS6KA10.43422762
115RPS6KA40.42659110
116CAMK10.42429655
117PAK30.41901210
118EPHB10.41470760
119CDK140.40175432
120CAMK2D0.40138144
121CDK80.39772750
122MAPKAPK20.39620598
123TBK10.39477017
124BUB10.39350277
125STK38L0.39238621
126AURKA0.38235821
127NME20.37203659
128MAPK120.37110529
129CDK150.37081761
130PRKAA10.36771490
131PDK20.36454790
132CAMK2G0.36409108
133TLK10.36111131
134AKT20.36102156
135AKT30.36039094
136MAP2K20.35952840
137CDK11A0.35768568
138PRKCI0.35314725
139PIK3CG0.34508124
140MAP3K20.32826123
141CHUK0.32242691
142MAP3K130.30946075
143MAP3K10.29400742
144PTK2B0.28215686

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.42783253
2Hippo signaling pathway_Homo sapiens_hsa043902.68508510
3Bladder cancer_Homo sapiens_hsa052192.64344876
4p53 signaling pathway_Homo sapiens_hsa041152.34235728
5Hedgehog signaling pathway_Homo sapiens_hsa043402.31907162
6Adherens junction_Homo sapiens_hsa045202.31303128
7Base excision repair_Homo sapiens_hsa034102.15281903
8Mismatch repair_Homo sapiens_hsa034302.06620209
9ECM-receptor interaction_Homo sapiens_hsa045122.05421745
10Focal adhesion_Homo sapiens_hsa045102.04415660
11mTOR signaling pathway_Homo sapiens_hsa041501.98871562
12Basal cell carcinoma_Homo sapiens_hsa052171.98269779
13TGF-beta signaling pathway_Homo sapiens_hsa043501.94112726
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.86049138
15Proteoglycans in cancer_Homo sapiens_hsa052051.83650531
16Tight junction_Homo sapiens_hsa045301.80375816
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79137462
18Other glycan degradation_Homo sapiens_hsa005111.73425695
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64921575
20Small cell lung cancer_Homo sapiens_hsa052221.62905659
21Shigellosis_Homo sapiens_hsa051311.52776030
22MicroRNAs in cancer_Homo sapiens_hsa052061.52360552
23Prion diseases_Homo sapiens_hsa050201.49328788
24Regulation of actin cytoskeleton_Homo sapiens_hsa048101.47769253
25Notch signaling pathway_Homo sapiens_hsa043301.47448376
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.45907564
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.44225731
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42671597
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42338824
30Vitamin B6 metabolism_Homo sapiens_hsa007501.40014466
31Fatty acid metabolism_Homo sapiens_hsa012121.37580708
32DNA replication_Homo sapiens_hsa030301.35136398
33RNA transport_Homo sapiens_hsa030131.34342569
34Chronic myeloid leukemia_Homo sapiens_hsa052201.33221764
35Wnt signaling pathway_Homo sapiens_hsa043101.32448124
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31989572
37AMPK signaling pathway_Homo sapiens_hsa041521.29760124
38Biosynthesis of amino acids_Homo sapiens_hsa012301.28296883
39VEGF signaling pathway_Homo sapiens_hsa043701.23442928
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22111836
41Arginine and proline metabolism_Homo sapiens_hsa003301.20515607
42Sulfur relay system_Homo sapiens_hsa041221.15102410
43PI3K-Akt signaling pathway_Homo sapiens_hsa041511.14023140
44Axon guidance_Homo sapiens_hsa043601.13941029
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.11106285
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10460354
47Thyroid cancer_Homo sapiens_hsa052161.07555776
48Viral myocarditis_Homo sapiens_hsa054161.04128125
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03917242
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03666276
51Vibrio cholerae infection_Homo sapiens_hsa051101.03431347
52Melanoma_Homo sapiens_hsa052181.03266210
53Insulin signaling pathway_Homo sapiens_hsa049101.02259354
54Cell cycle_Homo sapiens_hsa041101.00979611
55mRNA surveillance pathway_Homo sapiens_hsa030151.00033321
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99795411
57Nucleotide excision repair_Homo sapiens_hsa034200.96557378
58Amoebiasis_Homo sapiens_hsa051460.94608635
59Dilated cardiomyopathy_Homo sapiens_hsa054140.93682576
60Fructose and mannose metabolism_Homo sapiens_hsa000510.92667121
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91804072
62Colorectal cancer_Homo sapiens_hsa052100.91089295
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89866349
64Phenylalanine metabolism_Homo sapiens_hsa003600.89758355
65Pathways in cancer_Homo sapiens_hsa052000.88267956
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84198262
67HIF-1 signaling pathway_Homo sapiens_hsa040660.83731160
68Viral carcinogenesis_Homo sapiens_hsa052030.82270815
69Gap junction_Homo sapiens_hsa045400.81738550
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.80881595
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.79885715
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79275830
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.78002623
74Sulfur metabolism_Homo sapiens_hsa009200.77992376
75Circadian rhythm_Homo sapiens_hsa047100.77432913
76HTLV-I infection_Homo sapiens_hsa051660.76318324
77Estrogen signaling pathway_Homo sapiens_hsa049150.76130562
78ErbB signaling pathway_Homo sapiens_hsa040120.74901839
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.74425551
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74261357
81Spliceosome_Homo sapiens_hsa030400.74049219
82Acute myeloid leukemia_Homo sapiens_hsa052210.73334594
83Pentose phosphate pathway_Homo sapiens_hsa000300.72136749
84Endocytosis_Homo sapiens_hsa041440.72002322
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70601680
86Sphingolipid metabolism_Homo sapiens_hsa006000.70359362
87Rap1 signaling pathway_Homo sapiens_hsa040150.67682447
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67362411
89Folate biosynthesis_Homo sapiens_hsa007900.66593679
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66524842
91Prostate cancer_Homo sapiens_hsa052150.66079162
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65820502
93Pancreatic cancer_Homo sapiens_hsa052120.64088572
94Fatty acid elongation_Homo sapiens_hsa000620.64043249
95Glioma_Homo sapiens_hsa052140.63067567
96Glycerolipid metabolism_Homo sapiens_hsa005610.62901420
97Galactose metabolism_Homo sapiens_hsa000520.62596264
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.61872731
99Endometrial cancer_Homo sapiens_hsa052130.61576592
100Oocyte meiosis_Homo sapiens_hsa041140.60595750
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60575910
102Pyruvate metabolism_Homo sapiens_hsa006200.59874869
103Synaptic vesicle cycle_Homo sapiens_hsa047210.59523520
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58973431
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.58446441
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58421987
107Insulin resistance_Homo sapiens_hsa049310.57695541
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57455814
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57427753
110Apoptosis_Homo sapiens_hsa042100.56713888
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55113541
112Tyrosine metabolism_Homo sapiens_hsa003500.54454652
113Protein digestion and absorption_Homo sapiens_hsa049740.54072847
114Carbon metabolism_Homo sapiens_hsa012000.51725385
115Melanogenesis_Homo sapiens_hsa049160.51166496
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51165549
117Glucagon signaling pathway_Homo sapiens_hsa049220.50806942
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.50665227
119MAPK signaling pathway_Homo sapiens_hsa040100.50595988
120Renal cell carcinoma_Homo sapiens_hsa052110.48868741
121Glutathione metabolism_Homo sapiens_hsa004800.47886919
122N-Glycan biosynthesis_Homo sapiens_hsa005100.47046875
123Choline metabolism in cancer_Homo sapiens_hsa052310.45789727
124Lysosome_Homo sapiens_hsa041420.45088267
125beta-Alanine metabolism_Homo sapiens_hsa004100.44069302
126Ribosome_Homo sapiens_hsa030100.41158606
127PPAR signaling pathway_Homo sapiens_hsa033200.41019436
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40733111
129Salmonella infection_Homo sapiens_hsa051320.40695791
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39721865
131Lysine degradation_Homo sapiens_hsa003100.39593648
132GnRH signaling pathway_Homo sapiens_hsa049120.39400858
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38557035

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