PHKB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)8.01103895
2muscle filament sliding (GO:0030049)7.67086604
3actin-myosin filament sliding (GO:0033275)7.67086604
4actin-mediated cell contraction (GO:0070252)6.52130291
5skeletal muscle contraction (GO:0003009)6.47307473
6skeletal muscle adaptation (GO:0043501)6.28611978
7sarcoplasmic reticulum calcium ion transport (GO:0070296)6.07863339
8carnitine shuttle (GO:0006853)5.43283199
9creatine metabolic process (GO:0006600)5.21294715
10actin filament-based movement (GO:0030048)5.09931211
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.81836613
12fatty acid transmembrane transport (GO:1902001)4.80126012
13* glycogen catabolic process (GO:0005980)4.76449568
14valine metabolic process (GO:0006573)4.62302236
15skeletal muscle fiber development (GO:0048741)4.56415500
16regulation of relaxation of muscle (GO:1901077)4.48980514
17* glucan catabolic process (GO:0009251)4.48353641
18response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.47259819
19sarcomere organization (GO:0045214)4.38944973
20striated muscle contraction (GO:0006941)4.30288750
21* cellular polysaccharide catabolic process (GO:0044247)4.29169149
22regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.26373182
23plasma membrane repair (GO:0001778)4.21142708
24carnitine transmembrane transport (GO:1902603)4.20177626
25purine nucleotide salvage (GO:0032261)4.18870423
26glucan biosynthetic process (GO:0009250)4.15039438
27glycogen biosynthetic process (GO:0005978)4.15039438
28skeletal muscle tissue regeneration (GO:0043403)4.07656598
29pyrimidine ribonucleoside catabolic process (GO:0046133)4.06938697
30myofibril assembly (GO:0030239)4.02455371
31amino-acid betaine transport (GO:0015838)3.97988014
32carnitine transport (GO:0015879)3.97988014
33* polysaccharide catabolic process (GO:0000272)3.96546277
34regulation of cell communication by electrical coupling (GO:0010649)3.95222036
35striated muscle atrophy (GO:0014891)3.95141051
36response to muscle activity (GO:0014850)3.92182886
372-oxoglutarate metabolic process (GO:0006103)3.90981538
38myotube cell development (GO:0014904)3.90802428
39regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.87591441
40negative regulation of protein localization to cell surface (GO:2000009)3.73713260
41tricarboxylic acid metabolic process (GO:0072350)3.71443696
42regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.70169606
43IMP metabolic process (GO:0046040)3.68397470
44muscle contraction (GO:0006936)3.60724868
45* glycogen metabolic process (GO:0005977)3.54798165
46branched-chain amino acid metabolic process (GO:0009081)3.52629021
47response to inactivity (GO:0014854)3.49690721
48* cellular glucan metabolic process (GO:0006073)3.48836648
49* glucan metabolic process (GO:0044042)3.48836648
50interkinetic nuclear migration (GO:0022027)3.45016079
51striated muscle adaptation (GO:0014888)3.38921641
52actomyosin structure organization (GO:0031032)3.37940257
53branched-chain amino acid catabolic process (GO:0009083)3.37308515
54intracellular lipid transport (GO:0032365)3.35046934
55fatty acid beta-oxidation (GO:0006635)3.34448474
56tricarboxylic acid cycle (GO:0006099)3.33743318
57regulation of sequestering of triglyceride (GO:0010889)3.33158986
58positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.29325464
59aspartate family amino acid catabolic process (GO:0009068)3.27784018
60muscle atrophy (GO:0014889)3.23470203
61muscle system process (GO:0003012)3.22776552
62positive regulation of fatty acid beta-oxidation (GO:0032000)3.21194365
63regulation of hexokinase activity (GO:1903299)3.21003238
64regulation of glucokinase activity (GO:0033131)3.21003238
65regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.19721588
66regulation of sarcomere organization (GO:0060297)3.18325151
67fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.17925767
68lysine catabolic process (GO:0006554)3.17466952
69lysine metabolic process (GO:0006553)3.17466952
70regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.13787940
71quaternary ammonium group transport (GO:0015697)3.13558770
72regulation of acyl-CoA biosynthetic process (GO:0050812)3.10409580
73positive regulation of fatty acid oxidation (GO:0046321)3.06125798
74IMP biosynthetic process (GO:0006188)3.04750243
75cytidine metabolic process (GO:0046087)3.04636919
76cytidine catabolic process (GO:0006216)3.04636919
77cytidine deamination (GO:0009972)3.04636919
78regulation of actin filament-based movement (GO:1903115)3.04595549
79regulation of protein glycosylation (GO:0060049)3.01478730
80cardiac muscle contraction (GO:0060048)3.00427098
81muscle fiber development (GO:0048747)2.96153314
82succinate metabolic process (GO:0006105)2.96034663
83positive regulation of cardiac muscle hypertrophy (GO:0010613)2.96015391
84positive regulation of muscle hypertrophy (GO:0014742)2.96015391
85regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.94786471
86regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.92790239
87lipid oxidation (GO:0034440)2.91285566
88regulation of fatty acid oxidation (GO:0046320)2.91038293
89dicarboxylic acid biosynthetic process (GO:0043650)2.90900615
90relaxation of muscle (GO:0090075)2.90755863
91fatty acid oxidation (GO:0019395)2.90193614
92* cellular carbohydrate catabolic process (GO:0044275)2.89410248
93biotin metabolic process (GO:0006768)2.89015598
94phospholipid homeostasis (GO:0055091)2.86979995
95negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85904131
96positive regulation of histone deacetylation (GO:0031065)2.83807615
97relaxation of cardiac muscle (GO:0055119)2.80229252
98regulation of lipoprotein metabolic process (GO:0050746)2.78337091
99Golgi to endosome transport (GO:0006895)2.76976326
100positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.76733458
101establishment of protein localization to Golgi (GO:0072600)2.75108139
102response to activity (GO:0014823)2.74917831
103regulation of cofactor metabolic process (GO:0051193)2.73582602
104regulation of coenzyme metabolic process (GO:0051196)2.73582602
105insulin-like growth factor receptor signaling pathway (GO:0048009)2.73275251
106fatty acid catabolic process (GO:0009062)2.72848644
107fatty acid homeostasis (GO:0055089)2.72604141
108short-chain fatty acid metabolic process (GO:0046459)2.72227815
109regulation of skeletal muscle cell differentiation (GO:2001014)2.72156897
110cellular polysaccharide biosynthetic process (GO:0033692)2.71463353
111positive regulation of myoblast differentiation (GO:0045663)2.71386964
112nucleus localization (GO:0051647)2.71358670
113polysaccharide biosynthetic process (GO:0000271)2.70732279
114neuronal action potential propagation (GO:0019227)2.68547499
115carnitine metabolic process (GO:0009437)2.67818248
116macroautophagy (GO:0016236)2.66205815
117epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65680291
118cellular response to dexamethasone stimulus (GO:0071549)2.64410075
119positive regulation of glycolytic process (GO:0045821)2.63910579
120response to nitrosative stress (GO:0051409)2.63711616
121retrograde transport, vesicle recycling within Golgi (GO:0000301)2.63582593
122cell morphogenesis involved in neuron differentiation (GO:0048667)2.63405847
123* cellular polysaccharide metabolic process (GO:0044264)2.63242355
124negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.60280543
125protein targeting to Golgi (GO:0000042)2.60140807
126negative regulation of skeletal muscle tissue development (GO:0048642)2.59656301
127myotube differentiation (GO:0014902)2.58940966
128cardiac myofibril assembly (GO:0055003)2.58539997
129C4-dicarboxylate transport (GO:0015740)2.54821160
130vascular smooth muscle contraction (GO:0014829)2.50330923
131positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.49943786
132cardiac muscle hypertrophy (GO:0003300)2.47231613
133negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.46643713
134regulation of striated muscle contraction (GO:0006942)2.46397046
135reverse cholesterol transport (GO:0043691)2.41825656
136positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.41382373
137inner ear receptor stereocilium organization (GO:0060122)2.39401027
138high-density lipoprotein particle remodeling (GO:0034375)2.39075654
139regulation of integrin-mediated signaling pathway (GO:2001044)2.37670288
140phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.35707721
141striated muscle hypertrophy (GO:0014897)2.35508749
142photoreceptor cell differentiation (GO:0046530)2.33287694
143eye photoreceptor cell differentiation (GO:0001754)2.33287694
144brain morphogenesis (GO:0048854)2.32612472
145regulation of cilium movement (GO:0003352)2.31271826
146auditory receptor cell stereocilium organization (GO:0060088)2.26443453
147nerve growth factor signaling pathway (GO:0038180)2.24436370
148cellular component assembly involved in morphogenesis (GO:0010927)2.21089549
149positive regulation of cation channel activity (GO:2001259)2.19624158
150xenobiotic catabolic process (GO:0042178)2.18970183
151axoneme assembly (GO:0035082)2.18736442
152regulation of pigment cell differentiation (GO:0050932)2.17054206
153cellular ketone body metabolic process (GO:0046950)2.16858070

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.91268363
2GATA1_22025678_ChIP-Seq_K562_Human3.90816052
3GBX2_23144817_ChIP-Seq_PC3_Human3.53633086
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.30931217
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.26858319
6POU3F2_20337985_ChIP-ChIP_501MEL_Human3.20737522
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.17705530
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.73166304
9IGF1R_20145208_ChIP-Seq_DFB_Human2.60721393
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.52963770
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.49100221
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.44932120
13VDR_22108803_ChIP-Seq_LS180_Human2.42533496
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41432092
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.38833502
16CLOCK_20551151_ChIP-Seq_293T_Human2.36372876
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.27414576
18TBX20_22080862_ChIP-Seq_HEART_Mouse2.23021924
19TBX20_22328084_ChIP-Seq_HEART_Mouse2.23021924
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.19870903
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.19580437
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.19149435
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.14431795
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.12485565
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.04778273
26TAF15_26573619_Chip-Seq_HEK293_Human2.02848325
27EP300_21415370_ChIP-Seq_HL-1_Mouse2.02556760
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01463522
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.94816383
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.94612487
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.89661327
32* FUS_26573619_Chip-Seq_HEK293_Human1.86295722
33AR_21572438_ChIP-Seq_LNCaP_Human1.85484382
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85463171
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85359049
36* P300_19829295_ChIP-Seq_ESCs_Human1.83974793
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.81691392
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79792193
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78789347
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76514207
41* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76319085
42STAT3_23295773_ChIP-Seq_U87_Human1.76103769
43ER_23166858_ChIP-Seq_MCF-7_Human1.75073986
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70455703
45AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.66853123
46* TCF4_23295773_ChIP-Seq_U87_Human1.65104086
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.64632772
48* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.60859515
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60071096
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.59145457
51EWS_26573619_Chip-Seq_HEK293_Human1.59003707
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58011403
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57238806
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55787352
55NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55787352
56EZH2_22144423_ChIP-Seq_EOC_Human1.54789047
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.53342541
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51114337
59* FOXA2_19822575_ChIP-Seq_HepG2_Human1.46874381
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43638014
61CJUN_26792858_Chip-Seq_BT549_Human1.42363537
62AR_25329375_ChIP-Seq_VCAP_Human1.41209501
63P53_22387025_ChIP-Seq_ESCs_Mouse1.40663196
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39639500
65MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.39210007
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.37858409
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37184391
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36283222
69* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35928896
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35549327
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35454094
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33572561
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33237718
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.32823673
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.31260164
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30798153
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.27580967
78* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27088018
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.26590109
80* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26444909
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26162201
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25127642
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24751642
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.24610054
85* RXR_22108803_ChIP-Seq_LS180_Human1.24505185
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22539012
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.22147797
88NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21394201
89SCL_19346495_ChIP-Seq_HPC-7_Human1.20592035
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19098779
91OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19087237
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18184907
93SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17101630
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16574638
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16008141
96EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15456204
97STAT3_18555785_Chip-Seq_ESCs_Mouse1.15181801
98* RUNX2_22187159_ChIP-Seq_PCA_Human1.13457923
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13307349
100OCT4_18555785_Chip-Seq_ESCs_Mouse1.13303572
101BCAT_22108803_ChIP-Seq_LS180_Human1.13080615
102DROSHA_22980978_ChIP-Seq_HELA_Human1.12764295
103SMAD3_21741376_ChIP-Seq_HESCs_Human1.12675018
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12309866
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.11977261
106TCF4_22108803_ChIP-Seq_LS180_Human1.11068398
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10939134
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10939134
109AHR_22903824_ChIP-Seq_MCF-7_Human1.10583405
110SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10273359
111SOX2_19829295_ChIP-Seq_ESCs_Human1.10250611
112NANOG_19829295_ChIP-Seq_ESCs_Human1.10250611
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09651120
114FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09565446
115STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09518618
116FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09350272
117P300_18555785_Chip-Seq_ESCs_Mouse1.09281044
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08806504
119GATA4_21415370_ChIP-Seq_HL-1_Mouse1.08684547
120SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08602935
121TAL1_26923725_Chip-Seq_HPCs_Mouse1.08388000
122TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.07437133
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06667569
124CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06424498
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05861344
126ZNF274_21170338_ChIP-Seq_K562_Hela1.05611402
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05392067
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05277544
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05244382
130SOX2_18555785_Chip-Seq_ESCs_Mouse1.04748311
131GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04461960
132GATA2_21666600_ChIP-Seq_HMVEC_Human1.04270956
133FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01324499
134FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01247463
135THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01048233
136GATA1_19941826_ChIP-Seq_K562_Human1.00959706
137NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00498295
138Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00341278
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00025721
140KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98479705
141SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97250856
142TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96734058
143HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96418620
144RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95184920
145TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94064641
146ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93143519
147GATA4_25053715_ChIP-Seq_YYC3_Human0.93000283
148ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92902882
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.92123843
150TP53_18474530_ChIP-ChIP_U2OS_Human0.91054786
151ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90799044
152* GATA2_19941826_ChIP-Seq_K562_Human0.90735499
153VDR_24787735_ChIP-Seq_THP-1_Human0.90508077
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.89665160
155CBP_20019798_ChIP-Seq_JUKART_Human0.88757385
156IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88757385
157FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88729966
158TP53_16413492_ChIP-PET_HCT116_Human0.87829055
159BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87589503
160GATA3_24758297_ChIP-Seq_MCF-7_Human0.86863084
161NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86855267
162TCF4_18268006_ChIP-ChIP_LS174T_Human0.86534945
163CDX2_22108803_ChIP-Seq_LS180_Human0.86114115
164CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85976007
165PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85760162
166TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85109054
167AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83360626
168SOX2_21211035_ChIP-Seq_LN229_Gbm0.83338248
169TP63_23658742_ChIP-Seq_EP156T_Human0.83095464
170CBP_21632823_ChIP-Seq_H3396_Human0.82603482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio5.55646493
2MP0000749_muscle_degeneration4.87497608
3MP0003646_muscle_fatigue4.64936663
4MP0000751_myopathy4.26455363
5MP0004130_abnormal_muscle_cell3.86202682
6MP0004036_abnormal_muscle_relaxation3.79621517
7MP0000747_muscle_weakness3.36647372
8MP0002106_abnormal_muscle_physiology3.19767373
9MP0002837_dystrophic_cardiac_calcinosis3.15824567
10MP0004087_abnormal_muscle_fiber3.02424092
11MP0000759_abnormal_skeletal_muscle2.84028863
12MP0002269_muscular_atrophy2.83946644
13MP0005369_muscle_phenotype2.67297163
14MP0005620_abnormal_muscle_contractility2.63943788
15MP0005666_abnormal_adipose_tissue2.37307329
16MP0000750_abnormal_muscle_regeneration2.36984197
17MP0005670_abnormal_white_adipose2.33682687
18MP0004084_abnormal_cardiac_muscle2.30262959
19MP0000383_abnormal_hair_follicle2.08214282
20MP0000733_abnormal_muscle_development2.04730514
21MP0010678_abnormal_skin_adnexa1.97960864
22MP0004185_abnormal_adipocyte_glucose1.90884863
23MP0004233_abnormal_muscle_weight1.87885352
24MP0002876_abnormal_thyroid_physiology1.81808316
25MP0005330_cardiomyopathy1.76261789
26MP0002108_abnormal_muscle_morphology1.73075441
27MP0001661_extended_life_span1.70491407
28MP0005375_adipose_tissue_phenotype1.66008980
29MP0006036_abnormal_mitochondrial_physio1.64996618
30MP0009780_abnormal_chondrocyte_physiolo1.64520983
31MP0002139_abnormal_hepatobiliary_system1.63172916
32MP0010234_abnormal_vibrissa_follicle1.61835810
33MP0002971_abnormal_brown_adipose1.60407505
34MP0003705_abnormal_hypodermis_morpholog1.50961448
35MP0003195_calcinosis1.50491333
36MP0001299_abnormal_eye_distance/1.49975531
37MP0001984_abnormal_olfaction1.46909953
38MP0002972_abnormal_cardiac_muscle1.46899633
39MP0004043_abnormal_pH_regulation1.45976115
40MP0005220_abnormal_exocrine_pancreas1.45628436
41MP0010630_abnormal_cardiac_muscle1.45105210
42MP0003252_abnormal_bile_duct1.42086167
43MP0005464_abnormal_platelet_physiology1.42010954
44MP0008877_abnormal_DNA_methylation1.40890395
45MP0004085_abnormal_heartbeat1.40377130
46MP0004215_abnormal_myocardial_fiber1.32521189
47MP0002332_abnormal_exercise_endurance1.31640293
48MP0004270_analgesia1.31563279
49MP0002234_abnormal_pharynx_morphology1.30469402
50MP0002127_abnormal_cardiovascular_syste1.27398359
51MP0003806_abnormal_nucleotide_metabolis1.26502425
52MP0002009_preneoplasia1.25054665
53MP0009384_cardiac_valve_regurgitation1.20879089
54MP0003868_abnormal_feces_composition1.19338589
55MP0005334_abnormal_fat_pad1.17571248
56MP0005187_abnormal_penis_morphology1.16457045
57MP0004147_increased_porphyrin_level1.16361152
58MP0000427_abnormal_hair_cycle1.16342677
59MP0003122_maternal_imprinting1.15711775
60MP0002138_abnormal_hepatobiliary_system1.15153668
61MP0010329_abnormal_lipoprotein_level1.13757402
62MP0008775_abnormal_heart_ventricle1.11686046
63MP0004484_altered_response_of1.11441524
64MP0000013_abnormal_adipose_tissue1.11046053
65MP0008438_abnormal_cutaneous_collagen1.10948751
66MP0000230_abnormal_systemic_arterial1.09032504
67MP0000003_abnormal_adipose_tissue1.07861858
68MP0005385_cardiovascular_system_phenoty1.07292670
69MP0001544_abnormal_cardiovascular_syste1.07292670
70MP0003787_abnormal_imprinting1.06373532
71MP0005646_abnormal_pituitary_gland1.05216137
72MP0002102_abnormal_ear_morphology1.04802729
73MP0005360_urolithiasis1.01420013
74MP0002928_abnormal_bile_duct0.99874188
75MP0001986_abnormal_taste_sensitivity0.96801664
76MP0009697_abnormal_copulation0.95693730
77MP0005253_abnormal_eye_physiology0.95693111
78MP0009250_abnormal_appendicular_skeleto0.95409618
79MP0002118_abnormal_lipid_homeostasis0.93242508
80MP0008961_abnormal_basal_metabolism0.92483825
81MP0003690_abnormal_glial_cell0.91388216
82MP0002822_catalepsy0.90148638
83MP0003045_fibrosis0.89897425
84MP0002089_abnormal_postnatal_growth/wei0.89237900
85MP0005058_abnormal_lysosome_morphology0.89236792
86MP0010368_abnormal_lymphatic_system0.88781860
87MP0002078_abnormal_glucose_homeostasis0.88465002
88MP0000372_irregular_coat_pigmentation0.86613209
89MP0006054_spinal_hemorrhage0.86319102
90MP0005551_abnormal_eye_electrophysiolog0.85846061
91MP0001756_abnormal_urination0.85686839
92MP0003300_gastrointestinal_ulcer0.85419656
93MP0004134_abnormal_chest_morphology0.85371421
94MP0002254_reproductive_system_inflammat0.85221519
95MP0003183_abnormal_peptide_metabolism0.85210722
96MP0000631_abnormal_neuroendocrine_gland0.83572132
97MP0005167_abnormal_blood-brain_barrier0.83433673
98MP0004142_abnormal_muscle_tone0.83159425
99MP0005332_abnormal_amino_acid0.82882129
100MP0005584_abnormal_enzyme/coenzyme_acti0.82551540
101MP0008004_abnormal_stomach_pH0.82544252
102MP0001529_abnormal_vocalization0.82439695
103MP0003656_abnormal_erythrocyte_physiolo0.82179103
104MP0002909_abnormal_adrenal_gland0.82099753
105MP0002877_abnormal_melanocyte_morpholog0.80653417
106MP0003121_genomic_imprinting0.80097709
107MP0005365_abnormal_bile_salt0.78562817
108MP0001853_heart_inflammation0.77819122
109MP0002896_abnormal_bone_mineralization0.77567204
110MP0002638_abnormal_pupillary_reflex0.76461639
111MP0005084_abnormal_gallbladder_morpholo0.76409788
112MP0005266_abnormal_metabolism0.75646817
113MP0003950_abnormal_plasma_membrane0.73815476
114MP0003221_abnormal_cardiomyocyte_apopto0.73071571
115MP0006138_congestive_heart_failure0.73033436
116MP0005275_abnormal_skin_tensile0.72212850
117MP0003137_abnormal_impulse_conducting0.72006083
118MP0004924_abnormal_behavior0.71685519
119MP0005386_behavior/neurological_phenoty0.71685519
120MP0009115_abnormal_fat_cell0.70530025
121MP0004264_abnormal_extraembryonic_tissu0.69367022
122MP0000266_abnormal_heart_morphology0.69227345
123MP0005085_abnormal_gallbladder_physiolo0.68923886
124MP0001765_abnormal_ion_homeostasis0.68441755
125MP0001666_abnormal_nutrient_absorption0.68005484
126MP0005636_abnormal_mineral_homeostasis0.66690794
127MP0005319_abnormal_enzyme/_coenzyme0.62694868
128MP0000569_abnormal_digit_pigmentation0.62639438
129MP0003566_abnormal_cell_adhesion0.61859477
130MP0002128_abnormal_blood_circulation0.61063756
131MP0002168_other_aberrant_phenotype0.61020955
132MP0009672_abnormal_birth_weight0.60937711
133MP0001873_stomach_inflammation0.60387408
134MP0009703_decreased_birth_body0.59261698
135MP0003279_aneurysm0.58040452
136MP0001958_emphysema0.57901390
137MP0000343_altered_response_to0.57418874
138MP0000762_abnormal_tongue_morphology0.57106767
139MP0009643_abnormal_urine_homeostasis0.53807014
140MP0005248_abnormal_Harderian_gland0.53438660
141MP0003075_altered_response_to0.52705560
142MP0000609_abnormal_liver_physiology0.52002096
143MP0001346_abnormal_lacrimal_gland0.51552879
144MP0005166_decreased_susceptibility_to0.51101524
145MP0001270_distended_abdomen0.50353272
146MP0003959_abnormal_lean_body0.49230910

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)8.03868372
2Muscle fiber inclusion bodies (HP:0100299)8.01966227
3Exercise-induced muscle cramps (HP:0003710)7.80428998
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.72375503
5Nemaline bodies (HP:0003798)6.98862759
6Type 1 muscle fiber predominance (HP:0003803)5.96161587
7Muscle hypertrophy of the lower extremities (HP:0008968)5.94215729
8Distal arthrogryposis (HP:0005684)5.75904546
9Myoglobinuria (HP:0002913)5.64543522
10Ulnar deviation of the wrist (HP:0003049)5.44788796
11Calf muscle hypertrophy (HP:0008981)5.40756296
12Difficulty running (HP:0009046)5.19980284
13Round ear (HP:0100830)5.08498665
14Myopathic facies (HP:0002058)5.01987799
15Hyporeflexia of lower limbs (HP:0002600)4.73514036
16Muscle fiber splitting (HP:0003555)4.53584170
17Muscle stiffness (HP:0003552)4.32025585
18Rhabdomyolysis (HP:0003201)4.27962174
19Absent phalangeal crease (HP:0006109)4.13922834
20Calcaneovalgus deformity (HP:0001848)4.12492260
21EMG: myopathic abnormalities (HP:0003458)4.03701982
22Increased connective tissue (HP:0009025)3.84878015
23Deformed tarsal bones (HP:0008119)3.77438949
24Abnormal finger flexion creases (HP:0006143)3.77345617
25Abnormality of the calf musculature (HP:0001430)3.58465660
26Abnormality of the left ventricular outflow tract (HP:0011103)3.57850195
27Subaortic stenosis (HP:0001682)3.57850195
28Papillary thyroid carcinoma (HP:0002895)3.57264882
29Hyperkalemia (HP:0002153)3.54486549
30Myotonia (HP:0002486)3.48146310
31Bundle branch block (HP:0011710)3.42673609
32Rimmed vacuoles (HP:0003805)3.23822369
33Abnormality of skeletal muscle fiber size (HP:0012084)3.18090942
34Asymmetric septal hypertrophy (HP:0001670)3.14220132
35Hypoplastic ischia (HP:0003175)3.01318748
36Abnormality of the renal cortex (HP:0011035)2.98925769
37Increased variability in muscle fiber diameter (HP:0003557)2.91842199
38Decreased circulating renin level (HP:0003351)2.80718291
39Renal cortical cysts (HP:0000803)2.79860728
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.79664447
41Hypoglycemic coma (HP:0001325)2.78208073
42Neck muscle weakness (HP:0000467)2.75890674
43Malignant hyperthermia (HP:0002047)2.75176006
44Abnormality of the ischium (HP:0003174)2.71654748
45Frequent falls (HP:0002359)2.69366718
46Difficulty climbing stairs (HP:0003551)2.67291575
47Abnormality of the calcaneus (HP:0008364)2.66061907
48Ketoacidosis (HP:0001993)2.55957582
49Hyperventilation (HP:0002883)2.52370614
50Hypoalphalipoproteinemia (HP:0003233)2.50875654
51Thyroid carcinoma (HP:0002890)2.45282277
52Pelvic girdle muscle weakness (HP:0003749)2.39623594
53Poikilocytosis (HP:0004447)2.39349862
54Biliary tract neoplasm (HP:0100574)2.39242795
55Shoulder girdle muscle weakness (HP:0003547)2.33292381
56Abnormality of the hip-girdle musculature (HP:0001445)2.31839471
57Abnormality of the musculature of the pelvis (HP:0001469)2.31839471
58Abnormal biliary tract morphology (HP:0012440)2.30778230
59Increased mean platelet volume (HP:0011877)2.30471579
60Areflexia of lower limbs (HP:0002522)2.28928643
61Pancreatic fibrosis (HP:0100732)2.28034486
62Sudden death (HP:0001699)2.26527433
63Acanthocytosis (HP:0001927)2.25454567
64Scapular winging (HP:0003691)2.19457271
65Abnormality of the neuromuscular junction (HP:0003398)2.19358935
66Fatigable weakness (HP:0003473)2.19358935
67Medial flaring of the eyebrow (HP:0010747)2.19032226
68Mildly elevated creatine phosphokinase (HP:0008180)2.18521446
69Slender build (HP:0001533)2.16525527
70Tarsal synostosis (HP:0008368)2.15954458
71Broad metatarsal (HP:0001783)2.15387511
72Proximal amyotrophy (HP:0007126)2.11152742
73Hyperactive renin-angiotensin system (HP:0000841)2.10377061
74Generalized muscle weakness (HP:0003324)2.09036547
75Distal lower limb muscle weakness (HP:0009053)2.08680466
76Pancreatic cysts (HP:0001737)2.07284348
77Increased circulating renin level (HP:0000848)2.07252303
78Prolonged bleeding time (HP:0003010)2.04933026
79Muscular dystrophy (HP:0003560)2.03400576
80Chronic hepatic failure (HP:0100626)2.02953321
81Hyperuricemia (HP:0002149)2.02117963
82Increased purine levels (HP:0004368)2.02117963
83Limb-girdle muscle weakness (HP:0003325)2.00936087
84Facial diplegia (HP:0001349)2.00480965
85Absent speech (HP:0001344)1.99981982
86Genital tract atresia (HP:0001827)1.99288798
87Ketosis (HP:0001946)1.98803420
88Hypoplastic iliac wings (HP:0002866)1.98544965
89Neoplasm of the small intestine (HP:0100833)1.97398368
90Synostosis involving bones of the feet (HP:0009140)1.97115012
91Synostosis involving bones of the lower limbs (HP:0009138)1.97115012
92Heart block (HP:0012722)1.96256143
93Widely spaced teeth (HP:0000687)1.94584157
94Fair hair (HP:0002286)1.93737148
95Abnormality of potassium homeostasis (HP:0011042)1.93521077
96Congenital primary aphakia (HP:0007707)1.90977942
97Dilated cardiomyopathy (HP:0001644)1.90789843
98Hematochezia (HP:0002573)1.87875474
99Hyperinsulinemic hypoglycemia (HP:0000825)1.87733021
100Hyperaldosteronism (HP:0000859)1.86841647
101Ventricular arrhythmia (HP:0004308)1.86083716
102Abnormal platelet volume (HP:0011876)1.85446355
103Gait imbalance (HP:0002141)1.85075788
104Abnormality of the renal medulla (HP:0100957)1.84003658
105Limb-girdle muscle atrophy (HP:0003797)1.83999653
106True hermaphroditism (HP:0010459)1.83726860
107Ulnar deviation of finger (HP:0009465)1.83434462
108Spinal rigidity (HP:0003306)1.83126085
109Insulin-resistant diabetes mellitus (HP:0000831)1.81985018
110Pancreatic islet-cell hyperplasia (HP:0004510)1.81571094
111Centrally nucleated skeletal muscle fibers (HP:0003687)1.80662819
112Hypoglycemic seizures (HP:0002173)1.80632882
113Gowers sign (HP:0003391)1.79929316
114Tubulointerstitial nephritis (HP:0001970)1.79516708
115Nephrogenic diabetes insipidus (HP:0009806)1.78762297
116Syncope (HP:0001279)1.78506917
117Lipoatrophy (HP:0100578)1.77821336
118Vascular calcification (HP:0004934)1.77147081
119Abnormality of the shoulder girdle musculature (HP:0001435)1.74983664
120Bell-shaped thorax (HP:0001591)1.74876017
121Gaze-evoked nystagmus (HP:0000640)1.74490036
122Left ventricular hypertrophy (HP:0001712)1.73650647
123Chorioretinal atrophy (HP:0000533)1.73416472
124Abnormality of purine metabolism (HP:0004352)1.73021591
125Proximal tubulopathy (HP:0000114)1.72600128
126Tubular atrophy (HP:0000092)1.72345276
127Hemiparesis (HP:0001269)1.71841393
128Abnormal biliary tract physiology (HP:0012439)1.71578891
129Bile duct proliferation (HP:0001408)1.71578891
130Hyperglycemia (HP:0003074)1.70758890
131Ventricular tachycardia (HP:0004756)1.70560007
132Abnormality of renin-angiotensin system (HP:0000847)1.70374634
133Poor coordination (HP:0002370)1.67945842
134Hyperglycinuria (HP:0003108)1.67746515
135Abnormality of serine family amino acid metabolism (HP:0010894)1.67582165
136Abnormality of glycine metabolism (HP:0010895)1.67582165
137Oligomenorrhea (HP:0000876)1.67110410
138Mesomelia (HP:0003027)1.67092924
139EMG: neuropathic changes (HP:0003445)1.66817570
140Pheochromocytoma (HP:0002666)1.65256381
141Nonprogressive disorder (HP:0003680)1.64550677
142Ventricular fibrillation (HP:0001663)1.63997673
143Neoplasm of the rectum (HP:0100743)1.63844035
144Vaginal atresia (HP:0000148)1.63493085
145Increased density of long bones (HP:0006392)1.62903968
146Metaphyseal dysplasia (HP:0100255)1.62294115
147Paralysis (HP:0003470)1.61964109
148Aplasia/Hypoplasia of the tibia (HP:0005772)1.61370354
149Hypolipoproteinemia (HP:0010981)1.61291424
150Toxemia of pregnancy (HP:0100603)1.60101427
151Gout (HP:0001997)1.59378651
152Long clavicles (HP:0000890)1.58877730
153Bulbar palsy (HP:0001283)1.58522166
154Back pain (HP:0003418)1.57893061
155Hypokalemia (HP:0002900)1.55741994
156Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.55402264
157Metatarsus adductus (HP:0001840)1.55126632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.81032077
2TTN5.25876035
3PHKG14.67890748
4PHKG24.67890748
5PIK3CG3.06815631
6TRIB33.06575309
7BCKDK2.65696856
8SIK12.32835759
9AKT32.29355867
10CASK2.20601572
11PIK3CA2.14146231
12DMPK2.05654998
13NME12.05478475
14MAP3K72.03364773
15ACVR1B2.02166534
16MAP2K31.98980995
17TNIK1.96413465
18PDK31.94945247
19PDK41.94945247
20PINK11.85637771
21BMPR1B1.69918070
22STK391.63608847
23PNCK1.58707163
24PRKD31.50908588
25PTK61.48987952
26LMTK21.43011832
27PKN21.38816107
28TRIM281.36469514
29MAP3K41.35902812
30NEK11.32920491
31PLK21.32845013
32TRPM71.30967230
33NEK91.30387135
34STK38L1.29808544
35MAPK121.27614629
36MAP2K61.26136234
37PRKAA21.26098361
38PDK21.25709162
39FRK1.24328995
40PTK2B1.23258735
41NLK1.21775189
42LATS11.21126687
43INSRR1.19442657
44OXSR11.15518326
45BCR1.13615399
46MUSK1.13336047
47MARK11.12621336
48MET1.12139423
49STK101.10797831
50RIPK11.08270256
51MARK31.07501260
52NTRK31.06634302
53KSR11.00325806
54CCNB10.97802762
55CAMK1D0.97099493
56CAMK1G0.95614682
57EPHB10.92840708
58EEF2K0.92790036
59NUAK10.92349620
60PRKAA10.91829154
61TYK20.87142763
62IRAK30.85816110
63MST40.81046876
64MAP3K100.80441414
65TEC0.73994532
66PRKCE0.73285622
67STK240.70291475
68LRRK20.69965609
69SGK2230.69773777
70SGK4940.69773777
71MAP2K40.69232461
72ERN10.68469182
73FGFR30.67591493
74JAK10.67234950
75TIE10.67056687
76PRKD10.64155312
77MYLK0.64094378
78FLT30.62428856
79MAPK110.62415060
80PLK40.61689669
81MAPKAPK30.61414412
82ERBB20.59678509
83SGK30.59054016
84DAPK20.58195583
85PRKCH0.57652348
86AKT20.53399089
87WNK10.53375793
88TGFBR20.51280340
89MKNK20.50332243
90ZAK0.49832681
91CAMK2D0.49778372
92CSF1R0.49266140
93JAK30.49030652
94DDR20.47370576
95ILK0.47306390
96FGFR20.46579099
97CAMK2A0.45545800
98ADRBK20.45389015
99ERBB30.45082192
100MAP3K80.44453894
101TAOK30.44083566
102FGR0.43484621
103JAK20.43317557
104FGFR10.42750769
105SGK20.42428322
106MAPK70.41281413
107PDPK10.41029124
108SGK10.40823929
109MAP3K20.40816801
110BMX0.40013603
111IRAK10.39787948
112TAF10.39514259
113PRKACB0.39421882
114YES10.38919613
115PDGFRA0.38836167
116MAP3K30.38481877
117MAP2K70.37800516
118PRKACG0.36680223
119ERBB40.35736284
120MAP2K10.35584218
121ROCK10.35447657
122PRKACA0.35025854
123TGFBR10.34527884
124PDGFRB0.33904863
125ADRBK10.33661765
126PDK10.33545351
127CDK30.33011573
128CSNK1G10.32601913
129BRSK20.32279368
130PKN10.31742271
131CAMK2G0.31448410
132CDK60.30935142
133STK30.29903694
134* RPS6KA30.29785161
135MAPK150.28494534
136EPHA30.28042607
137GSK3A0.27871959
138PRKG10.27393475
139WNK30.27322565
140MTOR0.27052328
141RET0.25746335
142RPS6KA20.24788286
143PAK30.23499012
144SCYL20.23319141
145RPS6KB20.23069902
146MAPK130.22147322
147MAPK40.21289263
148WNK40.20971132
149HIPK20.20656701
150RPS6KB10.20325677
151FER0.19803270

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.98837374
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.38612181
3Propanoate metabolism_Homo sapiens_hsa006403.20300366
4Fatty acid degradation_Homo sapiens_hsa000712.94132383
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.85563902
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.58530665
7Fatty acid metabolism_Homo sapiens_hsa012122.47192354
8Starch and sucrose metabolism_Homo sapiens_hsa005002.44757322
9Fatty acid biosynthesis_Homo sapiens_hsa000612.35745296
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.18188046
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.96183876
12Dilated cardiomyopathy_Homo sapiens_hsa054141.85900944
13Carbon metabolism_Homo sapiens_hsa012001.82736852
14Insulin resistance_Homo sapiens_hsa049311.79615647
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.78373100
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.75185406
17PPAR signaling pathway_Homo sapiens_hsa033201.71357238
18* Glucagon signaling pathway_Homo sapiens_hsa049221.57523760
19Arginine biosynthesis_Homo sapiens_hsa002201.56839873
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56835169
21Butanoate metabolism_Homo sapiens_hsa006501.56659374
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49794913
23Sulfur metabolism_Homo sapiens_hsa009201.48843910
24* Insulin signaling pathway_Homo sapiens_hsa049101.43875913
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.43740045
26Pyruvate metabolism_Homo sapiens_hsa006201.40784428
27Peroxisome_Homo sapiens_hsa041461.40439958
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37943167
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37783587
30Lysine degradation_Homo sapiens_hsa003101.32214410
31Histidine metabolism_Homo sapiens_hsa003401.30667433
32AMPK signaling pathway_Homo sapiens_hsa041521.25797868
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24936079
34Galactose metabolism_Homo sapiens_hsa000521.23424454
35Circadian rhythm_Homo sapiens_hsa047101.20993815
36Linoleic acid metabolism_Homo sapiens_hsa005911.18830112
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10673282
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10403530
39Tryptophan metabolism_Homo sapiens_hsa003801.08651030
40Ether lipid metabolism_Homo sapiens_hsa005651.08372196
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.04692119
42Steroid biosynthesis_Homo sapiens_hsa001001.03043785
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02006672
44beta-Alanine metabolism_Homo sapiens_hsa004100.98236225
45Cardiac muscle contraction_Homo sapiens_hsa042600.96373530
46Biosynthesis of amino acids_Homo sapiens_hsa012300.95949571
47Focal adhesion_Homo sapiens_hsa045100.95579406
48Fructose and mannose metabolism_Homo sapiens_hsa000510.94790669
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91911875
50Retinol metabolism_Homo sapiens_hsa008300.90142145
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89060296
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86864362
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85528192
54Chemical carcinogenesis_Homo sapiens_hsa052040.85429207
55ABC transporters_Homo sapiens_hsa020100.85326811
56Regulation of autophagy_Homo sapiens_hsa041400.85175930
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84905526
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.83756926
59Arginine and proline metabolism_Homo sapiens_hsa003300.81742747
60Long-term depression_Homo sapiens_hsa047300.77705369
61Bile secretion_Homo sapiens_hsa049760.77321100
62Oxytocin signaling pathway_Homo sapiens_hsa049210.77204258
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73253244
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72260950
65Gastric acid secretion_Homo sapiens_hsa049710.70840002
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.69004144
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67853586
68Mineral absorption_Homo sapiens_hsa049780.67805624
69Circadian entrainment_Homo sapiens_hsa047130.63357718
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62752885
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59452266
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.58968444
73Fatty acid elongation_Homo sapiens_hsa000620.58742989
74Phototransduction_Homo sapiens_hsa047440.58382542
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57562338
76FoxO signaling pathway_Homo sapiens_hsa040680.55771060
77mTOR signaling pathway_Homo sapiens_hsa041500.55110414
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54740737
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54491490
80Proteoglycans in cancer_Homo sapiens_hsa052050.53585301
81Ovarian steroidogenesis_Homo sapiens_hsa049130.53545337
82Viral myocarditis_Homo sapiens_hsa054160.53362356
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53339949
84Tight junction_Homo sapiens_hsa045300.53291631
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52866807
86Pentose phosphate pathway_Homo sapiens_hsa000300.52342164
87Caffeine metabolism_Homo sapiens_hsa002320.51644293
88Renin-angiotensin system_Homo sapiens_hsa046140.51643082
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51364342
90Glycerolipid metabolism_Homo sapiens_hsa005610.50478086
91Insulin secretion_Homo sapiens_hsa049110.50201346
92* Calcium signaling pathway_Homo sapiens_hsa040200.48743410
93Inositol phosphate metabolism_Homo sapiens_hsa005620.48311043
94Type II diabetes mellitus_Homo sapiens_hsa049300.47855100
95Olfactory transduction_Homo sapiens_hsa047400.47465432
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.45422192
97ECM-receptor interaction_Homo sapiens_hsa045120.45337590
98Protein digestion and absorption_Homo sapiens_hsa049740.44480503
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43191731
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.42545524
101Platelet activation_Homo sapiens_hsa046110.42162304
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.41598583
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.41533937
104Choline metabolism in cancer_Homo sapiens_hsa052310.41215188
105HIF-1 signaling pathway_Homo sapiens_hsa040660.41114071
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40095636
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38406557
108Pancreatic secretion_Homo sapiens_hsa049720.38154697
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37849443
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37634748
111Thyroid hormone synthesis_Homo sapiens_hsa049180.35176936
112Sulfur relay system_Homo sapiens_hsa041220.32917557
113Renin secretion_Homo sapiens_hsa049240.32897495
114Amoebiasis_Homo sapiens_hsa051460.32161088
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30604970
116Fat digestion and absorption_Homo sapiens_hsa049750.30037848
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28026204
118Adherens junction_Homo sapiens_hsa045200.27572433
119Dorso-ventral axis formation_Homo sapiens_hsa043200.26114404
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25932365
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23902105
122Selenocompound metabolism_Homo sapiens_hsa004500.23629531
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21983704
124GnRH signaling pathway_Homo sapiens_hsa049120.21891398
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21174575
126Melanogenesis_Homo sapiens_hsa049160.18966386
127Complement and coagulation cascades_Homo sapiens_hsa046100.18704840

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