PHKA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9A, also known as X-linked liver glycogenosis. Alternatively spliced transcript variants have been reported, but the full-length nature of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)5.66476514
2regulation of protein activation cascade (GO:2000257)5.60325773
3very-low-density lipoprotein particle assembly (GO:0034379)5.55869375
4regulation of complement activation (GO:0030449)5.46406242
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.16944405
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.16944405
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.16944405
8modulation by symbiont of host immune response (GO:0052553)5.16944405
9positive regulation by symbiont of host defense response (GO:0052509)5.16944405
10modulation by symbiont of host defense response (GO:0052031)5.16944405
11regulation of fibrinolysis (GO:0051917)5.08210715
12cholesterol efflux (GO:0033344)4.95246251
13positive regulation of B cell differentiation (GO:0045579)4.93315751
14regulation of cholesterol esterification (GO:0010872)4.79421898
15phospholipid efflux (GO:0033700)4.66257463
16plasma lipoprotein particle organization (GO:0071827)4.60136314
17protein-lipid complex remodeling (GO:0034368)4.59940383
18macromolecular complex remodeling (GO:0034367)4.59940383
19plasma lipoprotein particle remodeling (GO:0034369)4.59940383
20high-density lipoprotein particle remodeling (GO:0034375)4.59354106
21intestinal cholesterol absorption (GO:0030299)4.42914556
22low-density lipoprotein particle remodeling (GO:0034374)4.37869897
23protein-lipid complex subunit organization (GO:0071825)4.36183822
24neutrophil mediated immunity (GO:0002446)4.12997018
25reverse cholesterol transport (GO:0043691)4.09022673
26regulation of interferon-beta biosynthetic process (GO:0045357)4.04578979
27negative regulation of protein activation cascade (GO:2000258)4.03306294
28phospholipid homeostasis (GO:0055091)4.02982683
29regulation of sequestering of triglyceride (GO:0010889)4.02517135
30negative regulation of granulocyte differentiation (GO:0030853)4.01029279
31blood coagulation, intrinsic pathway (GO:0007597)3.97159715
32diacylglycerol metabolic process (GO:0046339)3.96963538
33regulation of cholesterol homeostasis (GO:2000188)3.89386514
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.84838562
35positive regulation of gamma-delta T cell activation (GO:0046645)3.81631827
36positive regulation of triglyceride lipase activity (GO:0061365)3.79124556
37positive regulation of lipoprotein lipase activity (GO:0051006)3.79124556
38pinocytosis (GO:0006907)3.78465557
39L-phenylalanine catabolic process (GO:0006559)3.77885277
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.77885277
41negative regulation of sterol transport (GO:0032372)3.74297011
42negative regulation of cholesterol transport (GO:0032375)3.74297011
43histone H3-K36 demethylation (GO:0070544)3.66069867
44positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.64391118
45negative regulation of phagocytosis (GO:0050765)3.63241531
46regulation of humoral immune response (GO:0002920)3.58727836
47alpha-linolenic acid metabolic process (GO:0036109)3.57767114
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.55836643
49L-phenylalanine metabolic process (GO:0006558)3.55836643
50histone H3-K9 demethylation (GO:0033169)3.54217427
51fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.52768110
52macrophage activation involved in immune response (GO:0002281)3.47040068
53lipoprotein transport (GO:0042953)3.47029240
54low-density lipoprotein particle clearance (GO:0034383)3.46706621
55acute-phase response (GO:0006953)3.44816600
56response to host immune response (GO:0052572)3.40856456
57response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.40856456
58fatty acid transmembrane transport (GO:1902001)3.40127538
59histone H3-K4 trimethylation (GO:0080182)3.37634743
60response to host (GO:0075136)3.34125364
61response to host defenses (GO:0052200)3.34125364
62response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.34125364
63response to muramyl dipeptide (GO:0032495)3.30234727
64disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.26408187
65killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.26408187
66regulation of cholesterol storage (GO:0010885)3.25604702
67negative regulation of complement activation (GO:0045916)3.23914832
68negative regulation of erythrocyte differentiation (GO:0045647)3.23353405
69triglyceride homeostasis (GO:0070328)3.21750518
70acylglycerol homeostasis (GO:0055090)3.21750518
71lipoprotein metabolic process (GO:0042157)3.20219048
72carnitine shuttle (GO:0006853)3.19382088
73cholesterol homeostasis (GO:0042632)3.16613423
74protein activation cascade (GO:0072376)3.16162969
75regulation of triglyceride catabolic process (GO:0010896)3.13812812
76regulation of plasminogen activation (GO:0010755)3.12516673
77sterol homeostasis (GO:0055092)3.12163613
78germinal center formation (GO:0002467)3.07177649
79positive regulation of fatty acid biosynthetic process (GO:0045723)3.06882175
80mannose metabolic process (GO:0006013)3.04942801
81necroptotic process (GO:0070266)3.04206893
82positive regulation of interferon-alpha production (GO:0032727)3.03292673
83negative regulation of lipase activity (GO:0060192)3.01079616
84intestinal absorption (GO:0050892)3.00885366
85cholesterol transport (GO:0030301)2.99246208
86sterol transport (GO:0015918)2.99246208
87myeloid leukocyte mediated immunity (GO:0002444)2.98783283
88triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.98416644
89regulation of B cell differentiation (GO:0045577)2.98316838
90regulation of cholesterol metabolic process (GO:0090181)2.97829133
91negative regulation of fatty acid biosynthetic process (GO:0045717)2.96110065
92positive regulation of histone deacetylation (GO:0031065)2.95644048
93valine metabolic process (GO:0006573)2.95200794
94immunoglobulin mediated immune response (GO:0016064)2.94787565
95positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.94478578
96antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.94071642
97antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94071642
98positive regulation of steroid metabolic process (GO:0045940)2.93769769
99regulation of fatty acid biosynthetic process (GO:0042304)2.90406341
100negative regulation of humoral immune response (GO:0002921)2.89817948
101plasma lipoprotein particle clearance (GO:0034381)2.88902732
102positive regulation of fatty acid beta-oxidation (GO:0032000)2.88598613
103detection of molecule of bacterial origin (GO:0032490)2.86517365
104negative regulation of digestive system process (GO:0060457)2.85895881
105complement activation, classical pathway (GO:0006958)2.85781667
106imidazole-containing compound metabolic process (GO:0052803)2.81651037
107regulation of interferon-alpha production (GO:0032647)2.81377636
108regulation of B cell receptor signaling pathway (GO:0050855)2.81163650
109positive regulation of hemostasis (GO:1900048)2.80761962
110positive regulation of blood coagulation (GO:0030194)2.80761962
111cellular extravasation (GO:0045123)2.80515678
112positive regulation of extracellular matrix organization (GO:1903055)2.80189050
113lipid homeostasis (GO:0055088)2.78530901
114positive regulation of cellular amide metabolic process (GO:0034250)2.76692249
115B cell homeostasis (GO:0001782)2.76573219
116regulation of interleukin-8 biosynthetic process (GO:0045414)2.76425126
117carnitine transmembrane transport (GO:1902603)2.76103704
118modification by symbiont of host morphology or physiology (GO:0044003)2.76037647
119myeloid cell activation involved in immune response (GO:0002275)2.74841399
120neutrophil activation involved in immune response (GO:0002283)2.74782525
121negative regulation of lipid storage (GO:0010888)2.74671162
122glutamate metabolic process (GO:0006536)2.72868412
123mitotic sister chromatid cohesion (GO:0007064)2.72515500
124regulation of bile acid biosynthetic process (GO:0070857)2.71776339
125regulation of cholesterol biosynthetic process (GO:0045540)2.70972623
126urea metabolic process (GO:0019627)2.69752963
127urea cycle (GO:0000050)2.69752963
128embryonic process involved in female pregnancy (GO:0060136)2.69293506
129microglial cell activation (GO:0001774)2.68805744
130negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.68778428
131plasma lipoprotein particle assembly (GO:0034377)2.68752974
132complement activation (GO:0006956)2.68397126
133proline metabolic process (GO:0006560)2.68289877
134complement activation, alternative pathway (GO:0006957)2.66530894
135histone lysine demethylation (GO:0070076)2.64209219
136regulation of phagocytosis (GO:0050764)2.63104155
137regulation of granulocyte differentiation (GO:0030852)2.61325462
138positive regulation of hormone metabolic process (GO:0032352)2.60509723
139nitrogen cycle metabolic process (GO:0071941)2.59328935
140ethanol oxidation (GO:0006069)2.59246315
141oligosaccharide catabolic process (GO:0009313)2.59225264
142regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.59164003
143positive regulation of coagulation (GO:0050820)2.59143775
144negative regulation of fatty acid transport (GO:2000192)2.57704424
145regulation of gamma-delta T cell activation (GO:0046643)2.57569902
146fibrinolysis (GO:0042730)2.57324813
147protein localization to kinetochore (GO:0034501)2.57001790
148pore complex assembly (GO:0046931)2.56470480
149cytolysis (GO:0019835)2.56155197
150protein-lipid complex assembly (GO:0065005)2.56005851
151modulation by symbiont of host cellular process (GO:0044068)2.55725661
152regulation of heterotypic cell-cell adhesion (GO:0034114)2.55558163
153positive regulation of cholesterol efflux (GO:0010875)2.54998034
154positive regulation of phagocytosis (GO:0050766)2.54140719
155positive regulation of sterol transport (GO:0032373)2.53127739
156positive regulation of cholesterol transport (GO:0032376)2.53127739
157regulation of fatty acid beta-oxidation (GO:0031998)2.51902992
158definitive hemopoiesis (GO:0060216)2.50902282
159pentose-phosphate shunt (GO:0006098)2.50306749
160killing of cells of other organism (GO:0031640)2.49912343
161disruption of cells of other organism (GO:0044364)2.49912343
162regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.49789994
163protein carboxylation (GO:0018214)2.49505728
164peptidyl-glutamic acid carboxylation (GO:0017187)2.49505728
165negative regulation of cell killing (GO:0031342)2.49240565
166negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.49240565
167amino-acid betaine transport (GO:0015838)2.49140224
168carnitine transport (GO:0015879)2.49140224
169natural killer cell mediated cytotoxicity (GO:0042267)2.48148088
170natural killer cell mediated immunity (GO:0002228)2.48148088
171peptidyl-lysine trimethylation (GO:0018023)2.47822611
172positive regulation of lipid catabolic process (GO:0050996)2.47792483
173regulation of gamma-delta T cell differentiation (GO:0045586)2.45790034
174fatty acid beta-oxidation (GO:0006635)2.45688826
175regulation of apoptotic cell clearance (GO:2000425)2.43954854
176dicarboxylic acid biosynthetic process (GO:0043650)2.43258817
177macroautophagy (GO:0016236)2.43094821
178programmed necrotic cell death (GO:0097300)2.42385275

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.31990679
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.14118374
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.70579066
4SCL_19346495_ChIP-Seq_HPC-7_Human3.44768732
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.25481147
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.24692395
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.19749367
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.09674837
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05978599
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.04041550
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.93264469
12VDR_21846776_ChIP-Seq_THP-1_Human2.69606164
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64895366
14GATA1_22025678_ChIP-Seq_K562_Human2.62161067
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.58129734
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55330929
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.55258793
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.51740890
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.45063655
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.31308082
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.31261115
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29042855
23LXR_22158963_ChIP-Seq_LIVER_Mouse2.20050623
24MYC_22102868_ChIP-Seq_BL_Human2.14957901
25SPI1_23127762_ChIP-Seq_K562_Human2.12172029
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08250110
27LXR_22292898_ChIP-Seq_THP-1_Human2.04221899
28TCF7_22412390_ChIP-Seq_EML_Mouse1.87633801
29VDR_24763502_ChIP-Seq_THP-1_Human1.82746267
30SPI1_23547873_ChIP-Seq_NB4_Human1.78616449
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76371483
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76263261
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74682111
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70738208
35HNF4A_19822575_ChIP-Seq_HepG2_Human1.68511564
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67808274
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66723428
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65545063
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.62190759
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.62101384
41RACK7_27058665_Chip-Seq_MCF-7_Human1.62091795
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.61691223
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58264355
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57586983
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57072794
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50884973
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49507679
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48925481
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48587362
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.47486863
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46675907
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.46610814
53MAF_26560356_Chip-Seq_TH2_Human1.45602759
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43216899
55MAF_26560356_Chip-Seq_TH1_Human1.42215412
56P68_20966046_ChIP-Seq_HELA_Human1.42112330
57PU_27001747_Chip-Seq_BMDM_Mouse1.39359349
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37765610
59SMC4_20622854_ChIP-Seq_HELA_Human1.37162450
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36520820
61AR_21909140_ChIP-Seq_LNCAP_Human1.36459492
62UTX_26944678_Chip-Seq_JUKART_Human1.35906334
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35852287
64MYB_26560356_Chip-Seq_TH1_Human1.35417772
65ZNF263_19887448_ChIP-Seq_K562_Human1.34863372
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31366427
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30720164
68SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.30618073
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29567990
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29462916
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.29363480
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29060073
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25583566
74BCOR_27268052_Chip-Seq_Bcells_Human1.25574639
75SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24828358
76RUNX_20019798_ChIP-Seq_JUKART_Human1.23329119
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23176293
78KDM2B_26808549_Chip-Seq_DND41_Human1.21796587
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21272142
80CLOCK_20551151_ChIP-Seq_293T_Human1.21090315
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18130244
82* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16958355
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16752677
84KDM2B_26808549_Chip-Seq_K562_Human1.16663235
85GATA6_25053715_ChIP-Seq_YYC3_Human1.15345627
86CIITA_25753668_ChIP-Seq_RAJI_Human1.13345681
87MYB_26560356_Chip-Seq_TH2_Human1.12449780
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12215738
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11681671
90VDR_24787735_ChIP-Seq_THP-1_Human1.09965290
91FOXA2_19822575_ChIP-Seq_HepG2_Human1.09676110
92TFEB_21752829_ChIP-Seq_HELA_Human1.09500202
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08832204
94* RUNX1_27514584_Chip-Seq_MCF-7_Human1.07564035
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07089758
96CREB1_26743006_Chip-Seq_LNCaP_Human1.06957185
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06453041
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06238651
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.05990824
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05924312
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05134083
102GATA1_19941826_ChIP-Seq_K562_Human1.03611692
103STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03312531
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03019423
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02874702
106ELK3_25401928_ChIP-Seq_HUVEC_Human1.02075211
107HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01593262
108ELF1_20517297_ChIP-Seq_JURKAT_Human1.00785205
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00402794
110* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99418957
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.98884406
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98562112
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98512430
114BCL6_27268052_Chip-Seq_Bcells_Human0.98419978
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98129188
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97677494
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96829859
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95807018
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95542242
120GATA2_19941826_ChIP-Seq_K562_Human0.95125665
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.94827138
122CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94317865
123PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93973151
124FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93656101
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.92866278
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92430101
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92284552
128STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90995188
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90177161
130TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87664620
131ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86911982
132NCOR1_26117541_ChIP-Seq_K562_Human0.86311803
133TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86100840
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83425783
135KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.81464167
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81078156
137FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80752559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.44580326
2MP0003172_abnormal_lysosome_physiology3.56843124
3MP0005451_abnormal_body_composition3.31174925
4MP0002396_abnormal_hematopoietic_system3.04435235
5MP0005058_abnormal_lysosome_morphology3.04361123
6MP0002139_abnormal_hepatobiliary_system2.73014893
7MP0005174_abnormal_tail_pigmentation2.63285171
8MP0003191_abnormal_cellular_cholesterol2.47778343
9MP0001666_abnormal_nutrient_absorption2.45678027
10MP0003195_calcinosis2.43753365
11MP0005670_abnormal_white_adipose2.37503465
12MP0009840_abnormal_foam_cell2.34379487
13MP0001835_abnormal_antigen_presentation2.30166814
14MP0004130_abnormal_muscle_cell2.28226503
15MP0002166_altered_tumor_susceptibility2.28177562
16MP0005360_urolithiasis2.25725688
17MP0005464_abnormal_platelet_physiology2.21876477
18MP0005409_darkened_coat_color2.15799636
19MP0002132_abnormal_respiratory_system2.12241789
20MP0005365_abnormal_bile_salt2.06889130
21MP0005397_hematopoietic_system_phenotyp2.06600237
22MP0001545_abnormal_hematopoietic_system2.06600237
23MP0010329_abnormal_lipoprotein_level2.06387551
24MP0003122_maternal_imprinting2.04920904
25MP0003300_gastrointestinal_ulcer2.00657200
26MP0010307_abnormal_tumor_latency2.00631198
27MP0003436_decreased_susceptibility_to1.99153637
28MP0002419_abnormal_innate_immunity1.89821186
29MP0009278_abnormal_bone_marrow1.79560717
30MP0001661_extended_life_span1.78712116
31MP0003303_peritoneal_inflammation1.76704520
32MP0000371_diluted_coat_color1.76397458
33MP0003183_abnormal_peptide_metabolism1.68348900
34MP0005076_abnormal_cell_differentiation1.66649371
35MP0003656_abnormal_erythrocyte_physiolo1.66103063
36MP0003868_abnormal_feces_composition1.63466912
37MP0004808_abnormal_hematopoietic_stem1.60241746
38MP0004264_abnormal_extraembryonic_tissu1.56777909
39MP0005666_abnormal_adipose_tissue1.55583981
40MP0005075_abnormal_melanosome_morpholog1.52816620
41MP0001853_heart_inflammation1.50050528
42MP0005408_hypopigmentation1.49377932
43MP0002006_tumorigenesis1.46959899
44MP0001800_abnormal_humoral_immune1.43435748
45MP0005085_abnormal_gallbladder_physiolo1.40971319
46MP0002138_abnormal_hepatobiliary_system1.40839723
47MP0003705_abnormal_hypodermis_morpholog1.40680132
48MP0003566_abnormal_cell_adhesion1.39952836
49MP0003123_paternal_imprinting1.38836383
50MP0003252_abnormal_bile_duct1.38226155
51MP0000609_abnormal_liver_physiology1.36980590
52MP0002971_abnormal_brown_adipose1.36941815
53MP0004381_abnormal_hair_follicle1.36201936
54MP0000685_abnormal_immune_system1.34763650
55MP0000015_abnormal_ear_pigmentation1.33595727
56MP0009115_abnormal_fat_cell1.32535615
57MP0002452_abnormal_antigen_presenting1.32339840
58MP0005025_abnormal_response_to1.29475712
59MP0005332_abnormal_amino_acid1.26803046
60MP0004185_abnormal_adipocyte_glucose1.22906821
61MP0009763_increased_sensitivity_to1.21527277
62MP0008260_abnormal_autophagy1.21013408
63MP0000604_amyloidosis1.18440365
64MP0002398_abnormal_bone_marrow1.18401905
65MP0008438_abnormal_cutaneous_collagen1.18324272
66MP0000689_abnormal_spleen_morphology1.18111092
67MP0003690_abnormal_glial_cell1.16416701
68MP0002089_abnormal_postnatal_growth/wei1.13883916
69MP0003111_abnormal_nucleus_morphology1.11501208
70MP0002723_abnormal_immune_serum1.09746264
71MP0002118_abnormal_lipid_homeostasis1.09407437
72MP0005083_abnormal_biliary_tract1.09040424
73MP0001819_abnormal_immune_cell1.08754159
74MP0002420_abnormal_adaptive_immunity1.07815136
75MP0003828_pulmonary_edema1.07408740
76MP0002928_abnormal_bile_duct1.04822091
77MP0001533_abnormal_skeleton_physiology1.03718647
78MP0002722_abnormal_immune_system1.03550416
79MP0010094_abnormal_chromosome_stability1.02934486
80MP0002970_abnormal_white_adipose1.02740375
81MP0005334_abnormal_fat_pad1.02177008
82MP0004019_abnormal_vitamin_homeostasis1.01244264
83MP0000003_abnormal_adipose_tissue0.99917570
84MP0000716_abnormal_immune_system0.99838635
85MP0005000_abnormal_immune_tolerance0.99659648
86MP0008469_abnormal_protein_level0.99381345
87MP0000598_abnormal_liver_morphology0.99265713
88MP0008875_abnormal_xenobiotic_pharmacok0.99018388
89MP0002009_preneoplasia0.98706689
90MP0005319_abnormal_enzyme/_coenzyme0.98634333
91MP0000465_gastrointestinal_hemorrhage0.97408109
92MP0005375_adipose_tissue_phenotype0.96876690
93MP0009333_abnormal_splenocyte_physiolog0.94817235
94MP0003763_abnormal_thymus_physiology0.93964571
95MP0009642_abnormal_blood_homeostasis0.93242536
96MP0001764_abnormal_homeostasis0.93192944
97MP0005387_immune_system_phenotype0.92271973
98MP0001790_abnormal_immune_system0.92271973
99MP0002429_abnormal_blood_cell0.92191543
100MP0000678_abnormal_parathyroid_gland0.91522026
101MP0003724_increased_susceptibility_to0.89680015
102MP0001873_stomach_inflammation0.89388099
103MP0001915_intracranial_hemorrhage0.86784928
104MP0001986_abnormal_taste_sensitivity0.85457105
105MP0010630_abnormal_cardiac_muscle0.85206287
106MP0001845_abnormal_inflammatory_respons0.83876188
107MP0003943_abnormal_hepatobiliary_system0.83339032
108MP0000566_synostosis0.83156607
109MP0002078_abnormal_glucose_homeostasis0.82638384
110MP0009643_abnormal_urine_homeostasis0.80489985
111MP0006082_CNS_inflammation0.79957138
112MP0009785_altered_susceptibility_to0.79910927
113MP0004947_skin_inflammation0.79875940
114MP0008961_abnormal_basal_metabolism0.79756591
115MP0010352_gastrointestinal_tract_polyps0.78401673
116MP0004147_increased_porphyrin_level0.77648406
117MP0005220_abnormal_exocrine_pancreas0.76725046
118MP0004510_myositis0.76402669
119MP0002075_abnormal_coat/hair_pigmentati0.75911941
120MP0002405_respiratory_system_inflammati0.75624718
121MP0000343_altered_response_to0.75208378
122MP0000703_abnormal_thymus_morphology0.71746770
123MP0005584_abnormal_enzyme/coenzyme_acti0.70321069
124MP0000249_abnormal_blood_vessel0.70299197
125MP0002933_joint_inflammation0.70187951
126MP0010155_abnormal_intestine_physiology0.69899733
127MP0000858_altered_metastatic_potential0.68238427
128MP0001958_emphysema0.67380558
129MP0005448_abnormal_energy_balance0.67067861
130MP0003077_abnormal_cell_cycle0.65993869
131MP0003075_altered_response_to0.65571197
132MP0005671_abnormal_response_to0.65253550
133MP0008057_abnormal_DNA_replication0.65035620
134MP0009703_decreased_birth_body0.64131573
135MP0002019_abnormal_tumor_incidence0.63879643

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)5.93189953
2Abnormality of the common coagulation pathway (HP:0010990)4.89518532
3Hypobetalipoproteinemia (HP:0003563)4.80486242
4Recurrent bacterial skin infections (HP:0005406)4.36742784
5Recurrent abscess formation (HP:0002722)4.07461905
6Spontaneous abortion (HP:0005268)3.89976666
7Hemorrhage of the eye (HP:0011885)3.81096630
8Glomerulonephritis (HP:0000099)3.77277098
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.66904396
10Chromsome breakage (HP:0040012)3.64639150
11Abnormality of the lumbar spine (HP:0100712)3.58852648
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46955154
13Abnormality of the fingertips (HP:0001211)3.33890869
14Menorrhagia (HP:0000132)3.26348920
15Hypolipoproteinemia (HP:0010981)3.25185035
16Increased cerebral lipofuscin (HP:0011813)3.22625522
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.19810588
18Absent frontal sinuses (HP:0002688)3.12629639
19Periodontitis (HP:0000704)3.09072431
20Abnormality of the thoracic spine (HP:0100711)3.01759406
21Prolonged bleeding time (HP:0003010)3.01024382
22Gingival bleeding (HP:0000225)2.98756654
23Recurrent gram-negative bacterial infections (HP:0005420)2.92248233
24Thoracic kyphosis (HP:0002942)2.90877039
25Gastrointestinal infarctions (HP:0005244)2.88095424
26Osteomalacia (HP:0002749)2.86890078
27Acanthocytosis (HP:0001927)2.85357386
28Axonal loss (HP:0003447)2.79784240
29Joint hemorrhage (HP:0005261)2.77201302
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.73478558
31Purpura (HP:0000979)2.68412654
32Recurrent skin infections (HP:0001581)2.65666187
33Complement deficiency (HP:0004431)2.60587260
34Eczematoid dermatitis (HP:0000976)2.56768707
35Myocardial infarction (HP:0001658)2.55679098
36Autoimmune thrombocytopenia (HP:0001973)2.54418474
37Thrombophlebitis (HP:0004418)2.53419092
38Xanthomatosis (HP:0000991)2.53130244
39Flat acetabular roof (HP:0003180)2.50899913
40Hypochromic anemia (HP:0001931)2.48078491
41Hyperlipoproteinemia (HP:0010980)2.45128130
42Narrow palate (HP:0000189)2.44871616
43Epistaxis (HP:0000421)2.44554401
44Nephritis (HP:0000123)2.40440333
45Broad palm (HP:0001169)2.39378533
46Asymmetry of the thorax (HP:0001555)2.33697726
47Abnormal platelet function (HP:0011869)2.33024296
48Impaired platelet aggregation (HP:0003540)2.33024296
49Volvulus (HP:0002580)2.32432764
50Delayed closure of the anterior fontanelle (HP:0001476)2.32229486
51Vacuolated lymphocytes (HP:0001922)2.31900331
52Long eyelashes (HP:0000527)2.31337272
53Deep venous thrombosis (HP:0002625)2.30585807
54Urethral obstruction (HP:0000796)2.26899626
55Conjugated hyperbilirubinemia (HP:0002908)2.25920240
56Recurrent fungal infections (HP:0002841)2.23161942
57Abnormality of complement system (HP:0005339)2.22616548
58Agnosia (HP:0010524)2.22564938
59Hypophosphatemic rickets (HP:0004912)2.20756388
60Pulmonary embolism (HP:0002204)2.20659119
61Neurodegeneration (HP:0002180)2.20581288
62Acute myeloid leukemia (HP:0004808)2.20445117
63Abnormal platelet volume (HP:0011876)2.19942997
64Cerebral aneurysm (HP:0004944)2.19125439
65Hypochromic microcytic anemia (HP:0004840)2.19029897
66Spondylolisthesis (HP:0003302)2.17724972
67Rickets (HP:0002748)2.16606445
68Abnormality of the intrinsic pathway (HP:0010989)2.16069083
69Abnormality of chromosome stability (HP:0003220)2.16046389
70Increased serum ferritin (HP:0003281)2.15475643
71Hepatocellular carcinoma (HP:0001402)2.15005982
72Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.14793458
73Macroorchidism (HP:0000053)2.13354418
74Gingivitis (HP:0000230)2.12692374
75Recurrent viral infections (HP:0004429)2.12431019
76Orchitis (HP:0100796)2.12313398
77Upper motor neuron abnormality (HP:0002127)2.12275038
78Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.10904133
79Myelodysplasia (HP:0002863)2.07169757
80Systemic lupus erythematosus (HP:0002725)2.07156998
81Poikilocytosis (HP:0004447)2.06964959
82Abnormality of carpal bone ossification (HP:0006257)2.06702452
83Abnormality of pyrimidine metabolism (HP:0004353)2.06577761
84Abnormal tarsal ossification (HP:0008369)2.06005617
85Frequent falls (HP:0002359)2.05498637
86Enlarged kidneys (HP:0000105)2.05098678
87Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04347322
88Abnormality of polysaccharide metabolism (HP:0011012)2.04347322
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04347322
90Clubbing of toes (HP:0100760)2.04278476
91Intrahepatic cholestasis (HP:0001406)2.04249228
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.04113385
93Cellulitis (HP:0100658)2.02029975
94Epidermoid cyst (HP:0200040)2.01961070
95Osteomyelitis (HP:0002754)2.00613692
96Amyloidosis (HP:0011034)2.00579066
97Acute hepatic failure (HP:0006554)1.97962017
98Disinhibition (HP:0000734)1.97310758
99Skin nodule (HP:0200036)1.97033737
100Optic neuritis (HP:0100653)1.96880436
101Retrobulbar optic neuritis (HP:0100654)1.96880436
102High pitched voice (HP:0001620)1.96869003
103Aplasia/Hypoplasia of the uvula (HP:0010293)1.95207891
104Bruising susceptibility (HP:0000978)1.94297829
105Hematochezia (HP:0002573)1.94219758
106Hypoplasia of the thymus (HP:0000778)1.94002090
107Thickened calvaria (HP:0002684)1.93973617
108Abnormality of liposaccharide metabolism (HP:0010968)1.91379738
109Abnormality of glycosphingolipid metabolism (HP:0004343)1.91379738
110Abnormality of glycolipid metabolism (HP:0010969)1.91379738
111Increased mean platelet volume (HP:0011877)1.91178306
112Abnormality of the peritoneum (HP:0002585)1.89965307
113Abnormality of the nasal septum (HP:0000419)1.89907159
114Mitral stenosis (HP:0001718)1.87531446
115Broad alveolar ridges (HP:0000187)1.86996288
116Flared metaphyses (HP:0003015)1.86509796
117Heterotopia (HP:0002282)1.86300059
118Loss of speech (HP:0002371)1.85978079
119Pathologic fracture (HP:0002756)1.85871501
120Prominent nose (HP:0000448)1.85639688
121Abnormality of macrophages (HP:0004311)1.84893291
122Thin bony cortex (HP:0002753)1.84697333
123Hypoalphalipoproteinemia (HP:0003233)1.84050070
124Spontaneous hematomas (HP:0007420)1.83206801
125Leukopenia (HP:0001882)1.83115071
126Chronic otitis media (HP:0000389)1.82361941
127Urinary glycosaminoglycan excretion (HP:0003541)1.81927843
128Mucopolysacchariduria (HP:0008155)1.81927843
129Vascular calcification (HP:0004934)1.81720760
130Abnormality of the frontal sinuses (HP:0002687)1.81679892
131Reticulocytosis (HP:0001923)1.81183432
132* Hypercholesterolemia (HP:0003124)1.79798770
133Fat malabsorption (HP:0002630)1.79399332
134Gastrointestinal inflammation (HP:0004386)1.78999789
135Facial hemangioma (HP:0000329)1.78592506
136Dysostosis multiplex (HP:0000943)1.78115407
137Seborrheic dermatitis (HP:0001051)1.77444985
138Polycythemia (HP:0001901)1.77285644
139Albinism (HP:0001022)1.77179574
140Peritonitis (HP:0002586)1.76642339
141Vaginal fistula (HP:0004320)1.76620982
142Mediastinal lymphadenopathy (HP:0100721)1.75463889
143Global brain atrophy (HP:0002283)1.74628192
144Hepatoblastoma (HP:0002884)1.74219361
145Arterial thrombosis (HP:0004420)1.74020355
146Osteolytic defects of the phalanges of the hand (HP:0009771)1.71555586
147Osteolytic defects of the hand bones (HP:0009699)1.71555586
148Abnormality of iron homeostasis (HP:0011031)1.71370760
149Spinal cord lesions (HP:0100561)1.71327885
150Syringomyelia (HP:0003396)1.71327885
151Joint swelling (HP:0001386)1.70715529
152Abnormality of transition element cation homeostasis (HP:0011030)1.70434766
153Low anterior hairline (HP:0000294)1.69659512
154Colitis (HP:0002583)1.69621115
155Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.69418201
156Myositis (HP:0100614)1.69065876
157Widely patent fontanelles and sutures (HP:0004492)1.68145932
158Increased IgE level (HP:0003212)1.67865995
159Obstructive lung disease (HP:0006536)1.67544948
160Chronic obstructive pulmonary disease (HP:0006510)1.67544948
161Coarse hair (HP:0002208)1.65214523
162Inflammation of the large intestine (HP:0002037)1.65063670
163Capillary hemangiomas (HP:0005306)1.63435976

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D3.82628233
2FGFR43.82616833
3ICK3.30675112
4CAMK1G3.14146006
5MAP2K32.75958274
6KIT2.69918177
7TAOK32.66801531
8CDK122.26804800
9PRPF4B2.10266904
10PKN22.01002144
11NEK21.99968989
12MAP4K11.97279416
13SIK11.96697647
14MAP3K101.92572477
15TRIB31.91634022
16TYK21.81862800
17SMG11.80408449
18PTK61.73597772
19TTN1.72836011
20CSF1R1.67565759
21BLK1.67233940
22MAP3K131.65673202
23WNK41.62228781
24CDK61.60871638
25FGFR31.60404429
26WNK11.52955883
27RIPK41.48467720
28TNK21.43749303
29RIPK11.41986029
30BTK1.40092569
31RET1.38392535
32EEF2K1.36473111
33JAK11.36418128
34ERN11.35561997
35FLT31.33943716
36CDC71.31435826
37SIK21.28183807
38MAPK111.21262904
39FGR1.17993689
40CDC42BPA1.15781242
41CDK41.14554539
42MAP3K21.13526844
43PIK3CG1.12684594
44TEC1.11006500
45IRAK41.10147348
46ATR1.04402564
47JAK31.04347444
48STK41.04084055
49MAP3K61.03976710
50MAP3K11.03617214
51TBK11.03304746
52MAP2K61.03179497
53TGFBR21.02566690
54SCYL21.02072759
55HCK1.02045827
56STK31.00240601
57FES0.99844689
58BRD40.99706145
59TAOK20.98220933
60JAK20.97807147
61MTOR0.97710388
62FGFR20.95562134
63PRKAA20.94189975
64MAP3K70.90646671
65SYK0.85172990
66TYRO30.85015475
67KSR20.84760387
68AKT30.83683725
69PDK20.82395955
70CDK90.82015249
71TAOK10.82011669
72DAPK20.81418876
73BRSK20.78511413
74PRKD20.77303218
75PIM10.75914864
76MAP3K140.75908952
77STK100.75118940
78TTK0.74743465
79NLK0.74014594
80EPHB10.73676836
81BCKDK0.72924111
82PDGFRA0.72767838
83BMX0.72459152
84RPS6KC10.72307143
85RPS6KL10.72307143
86PIM20.71829051
87CAMK40.71379816
88ITK0.71285618
89RPS6KA60.71184829
90PIK3CA0.71034393
91MATK0.70153971
92IKBKE0.68175180
93TRPM70.67113916
94SGK30.65713451
95LYN0.65442208
96MAP3K110.64925218
97MELK0.64925014
98MAP3K30.63582207
99MARK30.63150311
100ZAP700.62769615
101HIPK20.62713040
102IRAK30.62658836
103LCK0.61108579
104RPS6KB10.61087423
105RPS6KA40.60924937
106MAP3K50.59972244
107PDGFRB0.58834323
108DMPK0.57813242
109MARK20.57147553
110IKBKB0.56676175
111PDK10.55909170
112PAK40.54358919
113CHUK0.53925842
114CSK0.53597241
115PDPK10.50873280
116NEK90.50578473
117RPS6KB20.48693284
118EIF2AK10.48121349
119PRKAA10.46463267
120YES10.46427418
121CDK70.43671873
122MAP2K20.42775527
123FGFR10.42588950
124RPS6KA10.42135026
125ATM0.41587598
126MAPK120.41503939
127AKT10.41496886
128MAPK70.40850060
129MAP3K80.40642562
130EIF2AK20.40150866
131SGK10.40107131
132GRK60.39852865
133RPS6KA20.39247834
134SGK20.39136201
135PLK40.38409502
136EGFR0.37287752

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.33028413
2Lysine degradation_Homo sapiens_hsa003102.51872879
3Staphylococcus aureus infection_Homo sapiens_hsa051502.43041686
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.39153264
5PPAR signaling pathway_Homo sapiens_hsa033202.24263643
6Fatty acid degradation_Homo sapiens_hsa000712.23201933
7Nitrogen metabolism_Homo sapiens_hsa009102.22519691
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09396411
9Complement and coagulation cascades_Homo sapiens_hsa046101.99161129
10Fat digestion and absorption_Homo sapiens_hsa049751.92898637
11Fatty acid metabolism_Homo sapiens_hsa012121.90711556
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.85738421
13ABC transporters_Homo sapiens_hsa020101.85262541
14Phenylalanine metabolism_Homo sapiens_hsa003601.60047876
15Vitamin digestion and absorption_Homo sapiens_hsa049771.57842156
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.56176590
17B cell receptor signaling pathway_Homo sapiens_hsa046621.52378161
18Histidine metabolism_Homo sapiens_hsa003401.41877412
19Fructose and mannose metabolism_Homo sapiens_hsa000511.36873816
20Osteoclast differentiation_Homo sapiens_hsa043801.35987277
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35320918
22DNA replication_Homo sapiens_hsa030301.35095620
23Arginine biosynthesis_Homo sapiens_hsa002201.31723177
24One carbon pool by folate_Homo sapiens_hsa006701.31276584
25Insulin resistance_Homo sapiens_hsa049311.31163815
26Leishmaniasis_Homo sapiens_hsa051401.30157681
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28413730
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26283260
29Propanoate metabolism_Homo sapiens_hsa006401.26070881
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.24664538
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21151251
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20244472
33Peroxisome_Homo sapiens_hsa041461.18491576
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.16573541
35Lysosome_Homo sapiens_hsa041421.16315682
36Chronic myeloid leukemia_Homo sapiens_hsa052201.16288575
37Starch and sucrose metabolism_Homo sapiens_hsa005001.15196368
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14768515
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.14247777
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13233807
41Retinol metabolism_Homo sapiens_hsa008301.12704572
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12446560
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.11963592
44AMPK signaling pathway_Homo sapiens_hsa041521.07938191
45mTOR signaling pathway_Homo sapiens_hsa041501.06988144
46Fatty acid biosynthesis_Homo sapiens_hsa000611.06945772
47Type II diabetes mellitus_Homo sapiens_hsa049301.06691856
48Selenocompound metabolism_Homo sapiens_hsa004501.06508487
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03559781
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02159092
51Other glycan degradation_Homo sapiens_hsa005111.01727289
52Chemical carcinogenesis_Homo sapiens_hsa052041.01368270
53Tyrosine metabolism_Homo sapiens_hsa003501.00997962
54Tryptophan metabolism_Homo sapiens_hsa003800.98456906
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96244656
56Acute myeloid leukemia_Homo sapiens_hsa052210.95986979
57Small cell lung cancer_Homo sapiens_hsa052220.95983429
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95313775
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.95284981
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92833380
61beta-Alanine metabolism_Homo sapiens_hsa004100.92806507
62Toxoplasmosis_Homo sapiens_hsa051450.92537814
63Carbon metabolism_Homo sapiens_hsa012000.92182319
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91893842
65Mismatch repair_Homo sapiens_hsa034300.88571577
66Pentose phosphate pathway_Homo sapiens_hsa000300.86952335
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.86741877
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85306814
69Influenza A_Homo sapiens_hsa051640.85090485
70Tuberculosis_Homo sapiens_hsa051520.83921405
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.82991321
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81917478
73Fanconi anemia pathway_Homo sapiens_hsa034600.80980947
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80348425
75Glycerolipid metabolism_Homo sapiens_hsa005610.79183139
76Pancreatic cancer_Homo sapiens_hsa052120.79120463
77Non-small cell lung cancer_Homo sapiens_hsa052230.78244147
78Platelet activation_Homo sapiens_hsa046110.77353982
79Apoptosis_Homo sapiens_hsa042100.77325813
80VEGF signaling pathway_Homo sapiens_hsa043700.77164929
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77062828
82Inositol phosphate metabolism_Homo sapiens_hsa005620.76805266
83Butanoate metabolism_Homo sapiens_hsa006500.76525688
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.75797230
85Bile secretion_Homo sapiens_hsa049760.75391507
86Measles_Homo sapiens_hsa051620.75244000
87Base excision repair_Homo sapiens_hsa034100.74433823
88Prion diseases_Homo sapiens_hsa050200.73814453
89Sulfur relay system_Homo sapiens_hsa041220.70735261
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70656619
91Choline metabolism in cancer_Homo sapiens_hsa052310.70188590
92Endometrial cancer_Homo sapiens_hsa052130.66770331
93Malaria_Homo sapiens_hsa051440.66329674
94Hepatitis B_Homo sapiens_hsa051610.66271160
95Herpes simplex infection_Homo sapiens_hsa051680.65716345
96Pertussis_Homo sapiens_hsa051330.65436498
97* Insulin signaling pathway_Homo sapiens_hsa049100.65073389
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64003032
99T cell receptor signaling pathway_Homo sapiens_hsa046600.62850455
100Biosynthesis of amino acids_Homo sapiens_hsa012300.60948911
101MicroRNAs in cancer_Homo sapiens_hsa052060.59907457
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59825014
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59463605
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58439843
105Prolactin signaling pathway_Homo sapiens_hsa049170.58297529
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58098093
107Homologous recombination_Homo sapiens_hsa034400.58091515
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57636191
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57415538
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57298815
111FoxO signaling pathway_Homo sapiens_hsa040680.57085471
112Hepatitis C_Homo sapiens_hsa051600.55930371
113Renin-angiotensin system_Homo sapiens_hsa046140.55009911
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54804415
115Sphingolipid metabolism_Homo sapiens_hsa006000.50709775
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50707951
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.49017708
118Notch signaling pathway_Homo sapiens_hsa043300.48791412
119GnRH signaling pathway_Homo sapiens_hsa049120.48620960
120Cell cycle_Homo sapiens_hsa041100.48408095
121TNF signaling pathway_Homo sapiens_hsa046680.48089543
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47076014
123HIF-1 signaling pathway_Homo sapiens_hsa040660.46247007
124Legionellosis_Homo sapiens_hsa051340.45233044
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.44927535
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43015524
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42220606
128* Glucagon signaling pathway_Homo sapiens_hsa049220.42201238
129Galactose metabolism_Homo sapiens_hsa000520.41717873
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41340267
131Thyroid cancer_Homo sapiens_hsa052160.41210359
132Renal cell carcinoma_Homo sapiens_hsa052110.40821257
133Amoebiasis_Homo sapiens_hsa051460.40231256
134Steroid biosynthesis_Homo sapiens_hsa001000.40189231

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