PHKA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)9.14985927
2muscle filament sliding (GO:0030049)8.52711805
3actin-myosin filament sliding (GO:0033275)8.52711805
4sarcoplasmic reticulum calcium ion transport (GO:0070296)7.88019313
5skeletal muscle contraction (GO:0003009)7.73604999
6skeletal muscle adaptation (GO:0043501)7.39540346
7actin-mediated cell contraction (GO:0070252)6.99449155
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.90403651
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.48562485
10carnitine shuttle (GO:0006853)5.47078346
11plasma membrane repair (GO:0001778)5.44003392
12actin filament-based movement (GO:0030048)5.42691989
13striated muscle contraction (GO:0006941)5.29596393
14sarcomere organization (GO:0045214)5.14148500
15* glycogen catabolic process (GO:0005980)5.07608939
16skeletal muscle fiber development (GO:0048741)5.03741846
17regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.94362424
18response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.84481840
19creatine metabolic process (GO:0006600)4.82670915
20myofibril assembly (GO:0030239)4.79139420
21* glucan catabolic process (GO:0009251)4.68608243
22regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.63990106
23regulation of cell communication by electrical coupling (GO:0010649)4.60425418
24NADH metabolic process (GO:0006734)4.55780070
25myotube cell development (GO:0014904)4.54696324
26fatty acid transmembrane transport (GO:1902001)4.54517251
27striated muscle atrophy (GO:0014891)4.44327836
28* cellular polysaccharide catabolic process (GO:0044247)4.32972355
29muscle contraction (GO:0006936)4.29164423
30response to muscle activity (GO:0014850)4.26252092
31purine nucleotide salvage (GO:0032261)4.17414336
32striated muscle adaptation (GO:0014888)4.07351194
33* polysaccharide catabolic process (GO:0000272)4.02502718
34negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.00106204
35cardiac muscle contraction (GO:0060048)3.99353334
36carnitine transmembrane transport (GO:1902603)3.96419990
37glycogen biosynthetic process (GO:0005978)3.92070184
38glucan biosynthetic process (GO:0009250)3.92070184
39pyrimidine ribonucleoside catabolic process (GO:0046133)3.90566106
40response to inactivity (GO:0014854)3.89995241
41muscle cell cellular homeostasis (GO:0046716)3.87558215
42actomyosin structure organization (GO:0031032)3.84025557
43muscle system process (GO:0003012)3.82273247
44muscle atrophy (GO:0014889)3.82272725
45gluconeogenesis (GO:0006094)3.73215972
46negative regulation of potassium ion transmembrane transport (GO:1901380)3.70855099
47skeletal muscle tissue regeneration (GO:0043403)3.67456515
48cardiac muscle hypertrophy (GO:0003300)3.63600680
49muscle cell fate commitment (GO:0042693)3.63088933
50amino-acid betaine transport (GO:0015838)3.56105203
51carnitine transport (GO:0015879)3.56105203
52muscle fiber development (GO:0048747)3.54412064
53skeletal muscle tissue development (GO:0007519)3.53397030
54cytidine deamination (GO:0009972)3.52650236
55cytidine metabolic process (GO:0046087)3.52650236
56cytidine catabolic process (GO:0006216)3.52650236
57regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.48075984
58regulation of membrane repolarization (GO:0060306)3.46535764
59hexose biosynthetic process (GO:0019319)3.42796250
60negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.38595920
61fructose metabolic process (GO:0006000)3.37968228
62regulation of actin filament-based movement (GO:1903115)3.35014081
63* glycogen metabolic process (GO:0005977)3.33239630
64myotube differentiation (GO:0014902)3.29083323
65regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.28993787
66regulation of calcium ion transmembrane transport (GO:1903169)3.28689133
67regulation of calcium ion transmembrane transporter activity (GO:1901019)3.28689133
682-oxoglutarate metabolic process (GO:0006103)3.28425707
69cardiac myofibril assembly (GO:0055003)3.28252239
70* glucan metabolic process (GO:0044042)3.25064324
71* cellular glucan metabolic process (GO:0006073)3.25064324
72positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.24866782
73regulation of relaxation of muscle (GO:1901077)3.23787509
74potassium ion import (GO:0010107)3.20503288
75neuromuscular synaptic transmission (GO:0007274)3.20075489
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16662871
77neuronal action potential propagation (GO:0019227)3.13311109
78proline biosynthetic process (GO:0006561)3.13120456
79AMP metabolic process (GO:0046033)3.12818593
80muscle tissue morphogenesis (GO:0060415)3.11694367
81muscle adaptation (GO:0043500)3.11613669
82monosaccharide biosynthetic process (GO:0046364)3.06356430
83regulation of acyl-CoA biosynthetic process (GO:0050812)3.05857332
84regulation of skeletal muscle cell differentiation (GO:2001014)3.01052390
85regulation of striated muscle contraction (GO:0006942)3.00669034
86cardiac muscle tissue morphogenesis (GO:0055008)3.00253252
87neuromuscular junction development (GO:0007528)2.99878004
88muscle organ morphogenesis (GO:0048644)2.97216073
89muscle hypertrophy (GO:0014896)2.95814544
90regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.95429188
91muscle organ development (GO:0007517)2.94760871
92peptidyl-lysine dimethylation (GO:0018027)2.93703978
93IMP metabolic process (GO:0046040)2.92566255
94myoblast fusion (GO:0007520)2.92506879
95nuclear pore complex assembly (GO:0051292)2.90864996
96regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.90727631
97muscle structure development (GO:0061061)2.90180327
98oxaloacetate metabolic process (GO:0006107)2.90165695
99cellular response to dexamethasone stimulus (GO:0071549)2.89289945
100IMP biosynthetic process (GO:0006188)2.88656692
101regulation of translational fidelity (GO:0006450)2.87119755
102striated muscle cell development (GO:0055002)2.83974038
103cardiac muscle hypertrophy in response to stress (GO:0014898)2.81377767
104muscle hypertrophy in response to stress (GO:0003299)2.81377767
105cardiac muscle adaptation (GO:0014887)2.81377767
106glycolytic process (GO:0006096)2.81144657
107negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.81094329
108tricarboxylic acid cycle (GO:0006099)2.80806170
109response to activity (GO:0014823)2.79132353
110regulation of coenzyme metabolic process (GO:0051196)2.75847465
111regulation of cofactor metabolic process (GO:0051193)2.75847465
112cardiac muscle cell development (GO:0055013)2.73282950
113adult heart development (GO:0007512)2.73167637
114intracellular lipid transport (GO:0032365)2.72490036
115positive regulation of cation channel activity (GO:2001259)2.72482908
116C4-dicarboxylate transport (GO:0015740)2.70610865
117cellular potassium ion homeostasis (GO:0030007)2.68885741
118syncytium formation by plasma membrane fusion (GO:0000768)2.67986296
119positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.67316124
120mitotic chromosome condensation (GO:0007076)2.66912164
121regulation of hydrogen peroxide-induced cell death (GO:1903205)2.65712361
122response to dexamethasone (GO:0071548)2.65430976
123positive regulation of myotube differentiation (GO:0010831)2.65099587
124cellular carbohydrate biosynthetic process (GO:0034637)2.64011859
125striated muscle hypertrophy (GO:0014897)2.59119507
126regulation of the force of heart contraction (GO:0002026)2.57540324
127negative regulation of muscle hypertrophy (GO:0014741)2.57225925
128cardiac cell development (GO:0055006)2.56969015
129syncytium formation (GO:0006949)2.56764256
130cellular polysaccharide biosynthetic process (GO:0033692)2.56375095
131polysaccharide biosynthetic process (GO:0000271)2.56311750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.65492328
2BP1_19119308_ChIP-ChIP_Hs578T_Human2.80991633
3AR_21909140_ChIP-Seq_LNCAP_Human2.68947829
4AR_21572438_ChIP-Seq_LNCaP_Human2.56619553
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.52463421
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.47800359
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.44300428
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.41048121
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.37601138
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32270187
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.30828493
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.22568202
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18012930
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.15822714
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12153902
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11684633
17ZFX_18555785_ChIP-Seq_MESCs_Mouse2.09862931
18MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.03061774
19ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.94107172
20PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.93727842
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92242260
22STAT3_1855785_ChIP-Seq_MESCs_Mouse1.91920367
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89145199
24TBX20_22328084_ChIP-Seq_HEART_Mouse1.83185148
25TBX20_22080862_ChIP-Seq_HEART_Mouse1.83185148
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81070070
27DROSHA_22980978_ChIP-Seq_HELA_Human1.77682013
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.76433286
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76211015
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73008439
31CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.68406404
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66128109
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61479346
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.60309998
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59102689
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.55408601
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55058745
38CHD1_26751641_Chip-Seq_LNCaP_Human1.54244535
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51246127
40ZNF274_21170338_ChIP-Seq_K562_Hela1.51161810
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48796279
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48006023
43SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.47322045
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45750385
45TP53_20018659_ChIP-ChIP_R1E_Mouse1.45292478
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41925003
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41474857
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.40593166
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40360177
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39678999
51KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39664708
52ZNF263_19887448_ChIP-Seq_K562_Human1.37882516
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36277359
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35279376
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34657229
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34565093
57EZH2_22144423_ChIP-Seq_EOC_Human1.34474356
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33910002
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32336294
60CTCF_27219007_Chip-Seq_Bcells_Human1.31807045
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.31162159
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30553008
63LXR_22292898_ChIP-Seq_THP-1_Human1.30268771
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30159424
65* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29846813
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29276364
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29276364
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29156091
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28645359
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28144996
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27199313
72TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.27080033
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25791780
74KDM2B_26808549_Chip-Seq_K562_Human1.25684825
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24772424
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.24199048
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.23540521
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23141447
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22808025
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22605174
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21543110
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20147581
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19689088
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19680531
85XRN2_22483619_ChIP-Seq_HELA_Human1.19033333
86ATF3_27146783_Chip-Seq_COLON_Human1.18304021
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18194136
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17360135
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15903514
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15694618
91SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14155408
92EZH2_27294783_Chip-Seq_ESCs_Mouse1.13773485
93RNF2_27304074_Chip-Seq_ESCs_Mouse1.13240477
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13101947
95* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11309794
96FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10291730
97RARB_27405468_Chip-Seq_BRAIN_Mouse1.10124953
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09984565
99CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09805228
100POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09311518
101EZH2_27304074_Chip-Seq_ESCs_Mouse1.08844942
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07352038
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07266994
104KDM2B_26808549_Chip-Seq_DND41_Human1.06922130
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06543035
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06348641
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05865405
108FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04030866
109DCP1A_22483619_ChIP-Seq_HELA_Human1.03886233
110WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03465009
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03299540
112MYC_27129775_Chip-Seq_CORNEA_Mouse1.03190357
113SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02828289
114SOX17_20123909_ChIP-Seq_XEN_Mouse1.02822819
115HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02272821
116RACK7_27058665_Chip-Seq_MCF-7_Human1.01824423
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01749959
118* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01522761
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00299205
120TP53_23651856_ChIP-Seq_MEFs_Mouse0.99494115
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99395949
122* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99322701
123SOX2_21211035_ChIP-Seq_LN229_Gbm0.99138273
124UBF1/2_26484160_Chip-Seq_HMECs_Human0.99034849
125NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98280961
126CREB1_26743006_Chip-Seq_LNCaP_Human0.98212374
127RXR_22158963_ChIP-Seq_LIVER_Mouse0.98166811
128TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97987150
129GATA3_24758297_ChIP-Seq_MCF-7_Human0.97554317
130SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96560252
131AR_19668381_ChIP-Seq_PC3_Human0.96137446
132ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95001115
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94473408
134SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93999307
135NANOG_21062744_ChIP-ChIP_HESCs_Human0.93664289
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93608115
137E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92670918
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92190631
139SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91954279
140SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91954279
141POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91868508
142GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91817369
143CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91629719
144NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90964558
145TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90877103
146BCAT_22108803_ChIP-Seq_LS180_Human0.90746049
147NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90564553
148TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90536952
149SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89812293
150JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89020613
151RING1B_27294783_Chip-Seq_NPCs_Mouse0.88810409
152RING1B_27294783_Chip-Seq_ESCs_Mouse0.88739386
153TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88348926
154PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86612937
155FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86058186
156CLOCK_20551151_ChIP-Seq_293T_Human0.84826398
157SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84788325
158EED_16625203_ChIP-ChIP_MESCs_Mouse0.84618349
159SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83845208
160TET1_21490601_ChIP-Seq_MESCs_Mouse0.83035069
161ISL1_27105846_Chip-Seq_CPCs_Mouse0.82415343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.90815104
2MP0003646_muscle_fatigue5.63965386
3MP0000751_myopathy5.47175056
4MP0000749_muscle_degeneration5.24676642
5MP0000747_muscle_weakness3.72094484
6MP0004233_abnormal_muscle_weight3.70318575
7MP0002106_abnormal_muscle_physiology3.69695025
8MP0004036_abnormal_muscle_relaxation3.62221100
9MP0002269_muscular_atrophy3.54243537
10MP0000759_abnormal_skeletal_muscle3.32500902
11MP0004130_abnormal_muscle_cell3.30448704
12MP0005451_abnormal_body_composition3.27525853
13MP0005369_muscle_phenotype3.16339008
14MP0004087_abnormal_muscle_fiber3.14963555
15MP0002837_dystrophic_cardiac_calcinosis3.13482800
16MP0005620_abnormal_muscle_contractility2.75016952
17MP0000750_abnormal_muscle_regeneration2.72260958
18MP0002332_abnormal_exercise_endurance2.31371945
19MP0002108_abnormal_muscle_morphology2.29180390
20MP0005330_cardiomyopathy2.00533310
21MP0001661_extended_life_span1.96273950
22MP0000733_abnormal_muscle_development1.87377880
23MP0004215_abnormal_myocardial_fiber1.81293792
24MP0004084_abnormal_cardiac_muscle1.78046002
25MP0003137_abnormal_impulse_conducting1.64796049
26MP0004185_abnormal_adipocyte_glucose1.50066458
27MP0005171_absent_coat_pigmentation1.42761586
28MP0010630_abnormal_cardiac_muscle1.41917483
29MP0004270_analgesia1.37729166
30MP0003950_abnormal_plasma_membrane1.33727805
31MP0005666_abnormal_adipose_tissue1.31954738
32MP0010030_abnormal_orbit_morphology1.30132625
33MP0002971_abnormal_brown_adipose1.29921483
34MP0002972_abnormal_cardiac_muscle1.29583747
35MP0006036_abnormal_mitochondrial_physio1.18213925
36MP0003045_fibrosis1.17592098
37MP0003941_abnormal_skin_development1.10669034
38MP0000013_abnormal_adipose_tissue1.09739790
39MP0004484_altered_response_of1.08415772
40MP0009672_abnormal_birth_weight1.07110167
41MP0005375_adipose_tissue_phenotype1.03972366
42MP0003705_abnormal_hypodermis_morpholog1.02579395
43MP0005266_abnormal_metabolism1.02311089
44MP0004134_abnormal_chest_morphology1.00052621
45MP0001299_abnormal_eye_distance/0.99991177
46MP0006072_abnormal_retinal_apoptosis0.91263730
47MP0009250_abnormal_appendicular_skeleto0.91263020
48MP0008775_abnormal_heart_ventricle0.90944123
49MP0000537_abnormal_urethra_morphology0.89816410
50MP0010234_abnormal_vibrissa_follicle0.86807638
51MP0005670_abnormal_white_adipose0.85819950
52MP0004957_abnormal_blastocyst_morpholog0.85496320
53MP0001346_abnormal_lacrimal_gland0.85134831
54MP0004142_abnormal_muscle_tone0.84788389
55MP0002127_abnormal_cardiovascular_syste0.83681911
56MP0001544_abnormal_cardiovascular_syste0.83337548
57MP0005385_cardiovascular_system_phenoty0.83337548
58MP0009780_abnormal_chondrocyte_physiolo0.82754332
59MP0010352_gastrointestinal_tract_polyps0.82350676
60MP0003283_abnormal_digestive_organ0.82157124
61MP0001730_embryonic_growth_arrest0.81237326
62MP0004043_abnormal_pH_regulation0.78963310
63MP0002877_abnormal_melanocyte_morpholog0.78230211
64MP0004858_abnormal_nervous_system0.77388834
65MP0000003_abnormal_adipose_tissue0.76797247
66MP0008569_lethality_at_weaning0.76350825
67MP0005187_abnormal_penis_morphology0.75321100
68MP0000579_abnormal_nail_morphology0.73661812
69MP0010094_abnormal_chromosome_stability0.73344400
70MP0000762_abnormal_tongue_morphology0.72573712
71MP0002089_abnormal_postnatal_growth/wei0.71749420
72MP0004197_abnormal_fetal_growth/weight/0.71221193
73MP0008057_abnormal_DNA_replication0.71020220
74MP0003315_abnormal_perineum_morphology0.69300114
75MP0003984_embryonic_growth_retardation0.69134028
76MP0002009_preneoplasia0.67824367
77MP0008961_abnormal_basal_metabolism0.66571342
78MP0002088_abnormal_embryonic_growth/wei0.66144457
79MP0000266_abnormal_heart_morphology0.65205412
80MP0004510_myositis0.65134642
81MP0005380_embryogenesis_phenotype0.64872232
82MP0001672_abnormal_embryogenesis/_devel0.64872232
83MP0003221_abnormal_cardiomyocyte_apopto0.63932528
84MP0003111_abnormal_nucleus_morphology0.61803957
85MP0000678_abnormal_parathyroid_gland0.61102723
86MP0002234_abnormal_pharynx_morphology0.57543882
87MP0005334_abnormal_fat_pad0.56130349
88MP0000467_abnormal_esophagus_morphology0.55352130
89MP0003077_abnormal_cell_cycle0.55273688
90MP0002114_abnormal_axial_skeleton0.53951876
91* MP0002078_abnormal_glucose_homeostasis0.53579707
92MP0004272_abnormal_basement_membrane0.53467101
93MP0009115_abnormal_fat_cell0.53375894
94MP0002896_abnormal_bone_mineralization0.53282550
95MP0003279_aneurysm0.52583134
96MP0009703_decreased_birth_body0.52128462
97MP0002080_prenatal_lethality0.52101854
98MP0009697_abnormal_copulation0.52046566
99MP0004085_abnormal_heartbeat0.51320921
100MP0003828_pulmonary_edema0.49542645
101MP0009046_muscle_twitch0.49474663
102MP0001943_abnormal_respiration0.49436531
103MP0008932_abnormal_embryonic_tissue0.49339533
104MP0000534_abnormal_ureter_morphology0.49314774
105MP0001697_abnormal_embryo_size0.49022222
106MP0002796_impaired_skin_barrier0.48523819
107MP0002084_abnormal_developmental_patter0.48395089
108MP0003633_abnormal_nervous_system0.47452369
109MP0002249_abnormal_larynx_morphology0.47281804
110MP0006035_abnormal_mitochondrial_morpho0.47086628
111MP0004859_abnormal_synaptic_plasticity0.47038504
112MP0002086_abnormal_extraembryonic_tissu0.46193025
113MP0006138_congestive_heart_failure0.46090574
114MP0004147_increased_porphyrin_level0.46051750
115MP0003693_abnormal_embryo_hatching0.45278292
116MP0005058_abnormal_lysosome_morphology0.45143168
117MP0002822_catalepsy0.45125412
118MP0010368_abnormal_lymphatic_system0.44356103
119MP0003755_abnormal_palate_morphology0.44202349
120MP0001502_abnormal_circadian_rhythm0.43008154
121MP0002254_reproductive_system_inflammat0.42256898
122MP0000955_abnormal_spinal_cord0.42026108
123MP0002932_abnormal_joint_morphology0.41976543
124MP0002909_abnormal_adrenal_gland0.40552738
125MP0003385_abnormal_body_wall0.39599005
126MP0005253_abnormal_eye_physiology0.39459319
127MP0002066_abnormal_motor_capabilities/c0.39066861
128MP0005623_abnormal_meninges_morphology0.38580715
129MP0003948_abnormal_gas_homeostasis0.38217206
130MP0002067_abnormal_sensory_capabilities0.37200265
131MP0003634_abnormal_glial_cell0.36723418
132MP0003656_abnormal_erythrocyte_physiolo0.36439784
133MP0009384_cardiac_valve_regurgitation0.35723257
134MP0002116_abnormal_craniofacial_bone0.34226563
135MP0005076_abnormal_cell_differentiation0.33982031
136MP0005508_abnormal_skeleton_morphology0.33856574
137MP0002109_abnormal_limb_morphology0.33624779
138MP0005452_abnormal_adipose_tissue0.33482272
139MP0003806_abnormal_nucleotide_metabolis0.33082289
140MP0009278_abnormal_bone_marrow0.32810576

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.12299123
2Exercise-induced muscle cramps (HP:0003710)7.86605806
3* Exercise-induced myalgia (HP:0003738)7.83295545
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.80105954
5Nemaline bodies (HP:0003798)7.08710768
6Muscle hypertrophy of the lower extremities (HP:0008968)6.56523956
7Distal arthrogryposis (HP:0005684)6.17352154
8Type 1 muscle fiber predominance (HP:0003803)6.13928843
9Calf muscle hypertrophy (HP:0008981)5.84618784
10Round ear (HP:0100830)5.80055965
11Myopathic facies (HP:0002058)5.61215735
12Difficulty running (HP:0009046)5.47042394
13Ulnar deviation of the wrist (HP:0003049)5.32627276
14Muscle fiber splitting (HP:0003555)4.90719931
15Calcaneovalgus deformity (HP:0001848)4.84556604
16* Myoglobinuria (HP:0002913)4.63184987
17Hyporeflexia of lower limbs (HP:0002600)4.59561257
18Deformed tarsal bones (HP:0008119)4.38682944
19Abnormality of the calf musculature (HP:0001430)4.25067000
20Myotonia (HP:0002486)4.19489497
21Increased connective tissue (HP:0009025)4.13214072
22Absent phalangeal crease (HP:0006109)4.12890105
23EMG: myopathic abnormalities (HP:0003458)4.12440677
24Rhabdomyolysis (HP:0003201)4.05336491
25* Muscle stiffness (HP:0003552)3.77973513
26Abnormal finger flexion creases (HP:0006143)3.65321625
27Asymmetric septal hypertrophy (HP:0001670)3.64893065
28Abnormality of the left ventricular outflow tract (HP:0011103)3.46070344
29Subaortic stenosis (HP:0001682)3.46070344
30Hypoplastic ischia (HP:0003175)3.45769664
31Abnormality of skeletal muscle fiber size (HP:0012084)3.35235796
32Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.34546549
33Difficulty climbing stairs (HP:0003551)3.28364017
34Neck muscle weakness (HP:0000467)3.25865103
35Increased variability in muscle fiber diameter (HP:0003557)3.23846207
36Malignant hyperthermia (HP:0002047)3.13433031
37Abnormality of the ischium (HP:0003174)3.06719598
38Progressive muscle weakness (HP:0003323)2.98134386
39Abnormality of the calcaneus (HP:0008364)2.96520186
40Hyperkalemia (HP:0002153)2.95877770
41Bundle branch block (HP:0011710)2.94624230
42Sudden death (HP:0001699)2.94006013
43Rimmed vacuoles (HP:0003805)2.78783293
44Frequent falls (HP:0002359)2.72629856
45Pelvic girdle muscle weakness (HP:0003749)2.69554629
46Abnormality of the musculature of the pelvis (HP:0001469)2.65414182
47Abnormality of the hip-girdle musculature (HP:0001445)2.65414182
48Shoulder girdle muscle weakness (HP:0003547)2.62702738
49Abnormality of the neuromuscular junction (HP:0003398)2.62513711
50Fatigable weakness (HP:0003473)2.62513711
51Areflexia of lower limbs (HP:0002522)2.62343176
52EMG: neuropathic changes (HP:0003445)2.47134703
53Mildly elevated creatine phosphokinase (HP:0008180)2.38512458
54Muscular dystrophy (HP:0003560)2.37790895
55Bulbar palsy (HP:0001283)2.29677445
56Proximal amyotrophy (HP:0007126)2.29183349
57Large for gestational age (HP:0001520)2.22094468
58Gowers sign (HP:0003391)2.20530689
59Distal lower limb muscle weakness (HP:0009053)2.19361835
60Ragged-red muscle fibers (HP:0003200)2.06432548
61Limb-girdle muscle weakness (HP:0003325)2.04253277
62Lower limb amyotrophy (HP:0007210)2.01026688
63Slender build (HP:0001533)1.99137334
64Ulnar deviation of finger (HP:0009465)1.98391112
65Generalized muscle weakness (HP:0003324)1.98056492
66Long clavicles (HP:0000890)1.96983763
67Congenital hip dislocation (HP:0001374)1.91769953
68Abnormality of the pubic bones (HP:0003172)1.91083394
69Ketoacidosis (HP:0001993)1.89869390
70Scapular winging (HP:0003691)1.86991275
71Ventricular tachycardia (HP:0004756)1.86789944
72Tarsal synostosis (HP:0008368)1.84408467
73Spinal rigidity (HP:0003306)1.84120884
74Paralysis (HP:0003470)1.82092474
75Abnormality of the shoulder girdle musculature (HP:0001435)1.79244540
76Waddling gait (HP:0002515)1.78614009
77Abnormality of the foot musculature (HP:0001436)1.78414402
78Nonprogressive disorder (HP:0003680)1.76788768
79Right ventricular cardiomyopathy (HP:0011663)1.74868192
80Heart block (HP:0012722)1.74121877
81Prolonged QT interval (HP:0001657)1.73295856
82Bell-shaped thorax (HP:0001591)1.72830450
83Abnormal atrioventricular conduction (HP:0005150)1.72570779
84Foot dorsiflexor weakness (HP:0009027)1.71600319
85Facial diplegia (HP:0001349)1.71481523
86Hypoalphalipoproteinemia (HP:0003233)1.69759187
87Limb-girdle muscle atrophy (HP:0003797)1.67985536
88Synostosis involving bones of the lower limbs (HP:0009138)1.67161503
89Synostosis involving bones of the feet (HP:0009140)1.67161503
90Distal lower limb amyotrophy (HP:0008944)1.66870294
91Turricephaly (HP:0000262)1.65475790
92Dysmetric saccades (HP:0000641)1.64725662
93Fetal akinesia sequence (HP:0001989)1.64668364
94Lipoatrophy (HP:0100578)1.64602722
95Hip contracture (HP:0003273)1.64360728
96Metatarsus adductus (HP:0001840)1.62969811
97Ventricular arrhythmia (HP:0004308)1.62382239
98Abnormality of potassium homeostasis (HP:0011042)1.62380703
99Insulin-resistant diabetes mellitus (HP:0000831)1.61952991
100Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.58106543
101Popliteal pterygium (HP:0009756)1.57544122
102Abnormality of glycolysis (HP:0004366)1.55645729
103Pancreatic islet-cell hyperplasia (HP:0004510)1.55588695
104Short palpebral fissure (HP:0012745)1.54041994
105Dilated cardiomyopathy (HP:0001644)1.52092135
106Oligomenorrhea (HP:0000876)1.51391620
107Fibular aplasia (HP:0002990)1.50813167
108Respiratory insufficiency due to muscle weakness (HP:0002747)1.50633423
109Achilles tendon contracture (HP:0001771)1.48541756
110Weak cry (HP:0001612)1.46603073
111Atrial fibrillation (HP:0005110)1.46270770
112Toxemia of pregnancy (HP:0100603)1.45604226
113Broad metatarsal (HP:0001783)1.45201450
114Centrally nucleated skeletal muscle fibers (HP:0003687)1.43948011
115Hypokalemia (HP:0002900)1.43671735
116Back pain (HP:0003418)1.43613116
117Increased serum pyruvate (HP:0003542)1.42798819
118Gout (HP:0001997)1.42360808
119Progressive external ophthalmoplegia (HP:0000590)1.41998765
120Hyperglycemia (HP:0003074)1.41952295
121* Exercise intolerance (HP:0003546)1.37672924
122Diaphragmatic weakness (HP:0009113)1.37221646
123Abnormality of the Achilles tendon (HP:0005109)1.35028893
124Microglossia (HP:0000171)1.32752059
125Narrow face (HP:0000275)1.32030513
126Reduced subcutaneous adipose tissue (HP:0003758)1.32017957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.09068198
2TTN5.39861309
3* PHKG13.89086800
4* PHKG23.89086800
5PINK13.47226378
6NME13.01844704
7EEF2K2.91604302
8DDR22.73762256
9ICK2.53414344
10PIK3CG2.42203675
11TRIB32.35312188
12MAP3K61.95634242
13MST1R1.94418005
14DMPK1.94267569
15MAP3K71.83537409
16NEK11.77674075
17MAP2K31.71703834
18MAPK151.69824072
19MUSK1.57610750
20SIK11.51678084
21PDGFRA1.46138555
22PDK41.45024422
23PDK31.45024422
24PBK1.42902320
25RIPK11.40011683
26MAPK121.39995381
27INSRR1.37166004
28SCYL21.34148747
29TRPM71.32759608
30TYRO31.26276136
31EPHA21.25448156
32MAP2K41.20512582
33PIK3CA1.19564468
34CDK121.17801619
35BMX1.17571244
36PRKD21.16010072
37LMTK21.15600602
38MET1.07325563
39PRKD31.07263926
40* PRKAA11.06048838
41RPS6KB21.05822924
42TTK1.05725997
43TAOK21.04742691
44FGR1.00352837
45MAP3K110.92627449
46PDK20.89888003
47LATS10.89442641
48ERBB30.83802973
49BCKDK0.83743856
50CAMK1G0.83379935
51MAPK110.83096261
52EIF2AK10.82383338
53CAMK2G0.78498150
54CDC42BPA0.78153953
55PNCK0.77127229
56CCNB10.76981412
57DYRK1B0.76332860
58* PRKAA20.75955287
59CAMK1D0.74011427
60UHMK10.73386111
61LATS20.72281953
62IRAK30.70456585
63MAP2K60.69621753
64SGK10.68268673
65SMG10.67611916
66EPHA40.64457801
67RPS6KB10.60006906
68AKT20.56481472
69MATK0.55785366
70STK380.55369251
71STK240.53891153
72WNK10.53620485
73PTK20.53571634
74PRKD10.53204646
75BRAF0.52510097
76SGK30.50624327
77AKT30.50348667
78PAK60.50074860
79MAP2K10.49890464
80NTRK20.49527093
81CAMK2D0.48099149
82STK390.47982561
83MAP3K100.47731742
84CSK0.47115835
85NME20.46960429
86TNIK0.46594701
87MTOR0.46389567
88FGFR10.45713233
89PRPF4B0.45506916
90LIMK10.45276916
91GSK3A0.44757407
92* RPS6KA30.44736794
93WEE10.43519177
94TSSK60.43382471
95ERBB40.43228114
96PTK60.42188947
97MOS0.40784343
98CHEK10.38116979
99MAPKAPK30.37608191
100PRKACB0.37599254
101MAP3K40.36163402
102CDK70.36073116
103MAP3K90.35826889
104CAMK2A0.35448569
105EIF2AK30.35212846
106MAPK70.35142966
107HIPK20.35012058
108CDK80.34547044
109MAPK100.34312449
110BUB10.33980042
111MAPKAPK50.32649841
112PAK30.31622807
113MAP3K30.31579979
114CAMK40.31464862
115ILK0.31084387
116ROCK10.30505536
117PRKACG0.30196379
118CAMK2B0.30098946
119SGK20.29752559
120PRKCH0.29312237
121TAOK10.29009848
122CDK10.28547925
123NEK90.28181972
124FGFR20.27643414
125PLK10.27470696
126AURKB0.26926916
127PDPK10.26720675
128PKN20.26556380
129* PRKACA0.26364266
130PKN10.26274209
131SRPK10.26235897
132MAP3K80.26156032
133PDGFRB0.25693688
134RPS6KC10.25534122
135RPS6KL10.25534122
136PRKG10.25203201
137CHEK20.24791463
138ARAF0.24714250
139YES10.24006110
140KSR20.23836261
141ZAK0.23813403
142STK38L0.22887759
143MAP3K130.22646511
144CDK20.22510686
145RAF10.22323752
146MAPK140.22172820
147BRD40.22098975
148RPS6KA10.22085780
149CSNK1E0.21528026
150GSK3B0.21018124
151STK30.19484933
152FER0.19419302

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.03085443
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.25645982
3Circadian rhythm_Homo sapiens_hsa047103.17693875
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.06200075
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.05486726
6Dilated cardiomyopathy_Homo sapiens_hsa054142.91486632
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.72749514
8Cardiac muscle contraction_Homo sapiens_hsa042602.59257907
9Pentose phosphate pathway_Homo sapiens_hsa000302.21297860
10Fatty acid metabolism_Homo sapiens_hsa012122.20320861
11Starch and sucrose metabolism_Homo sapiens_hsa005002.19428004
12Propanoate metabolism_Homo sapiens_hsa006401.86722573
13* Insulin signaling pathway_Homo sapiens_hsa049101.77778153
14Oxytocin signaling pathway_Homo sapiens_hsa049211.73115508
15* Glucagon signaling pathway_Homo sapiens_hsa049221.72324833
16Insulin resistance_Homo sapiens_hsa049311.69905936
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62416995
18Fatty acid degradation_Homo sapiens_hsa000711.61805633
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59894323
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59644358
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.58151174
22Nitrogen metabolism_Homo sapiens_hsa009101.52393580
23AMPK signaling pathway_Homo sapiens_hsa041521.52193578
24Fructose and mannose metabolism_Homo sapiens_hsa000511.40938397
25Arginine and proline metabolism_Homo sapiens_hsa003301.40060140
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.36877123
27mTOR signaling pathway_Homo sapiens_hsa041501.35267247
28Galactose metabolism_Homo sapiens_hsa000521.34653476
29Carbon metabolism_Homo sapiens_hsa012001.30687288
30* Calcium signaling pathway_Homo sapiens_hsa040201.28578639
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.28509134
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27897623
33Biosynthesis of amino acids_Homo sapiens_hsa012301.25726444
34Insulin secretion_Homo sapiens_hsa049111.22252739
35Gastric acid secretion_Homo sapiens_hsa049711.20068722
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15189211
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13824975
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10520252
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10203659
40Phenylalanine metabolism_Homo sapiens_hsa003601.07892150
41Viral myocarditis_Homo sapiens_hsa054161.07520361
42Focal adhesion_Homo sapiens_hsa045101.06030133
43GnRH signaling pathway_Homo sapiens_hsa049121.05340460
44Tight junction_Homo sapiens_hsa045301.04191898
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96809901
46Adherens junction_Homo sapiens_hsa045200.95833312
47Thyroid cancer_Homo sapiens_hsa052160.94057803
48GABAergic synapse_Homo sapiens_hsa047270.90184479
49Lysine degradation_Homo sapiens_hsa003100.89947685
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.89268065
51Pyruvate metabolism_Homo sapiens_hsa006200.88396833
52Arginine biosynthesis_Homo sapiens_hsa002200.88325033
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.87103491
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83187554
55Dorso-ventral axis formation_Homo sapiens_hsa043200.82698056
56RNA transport_Homo sapiens_hsa030130.82175442
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81764909
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.80092065
59Renin secretion_Homo sapiens_hsa049240.78065014
60Nucleotide excision repair_Homo sapiens_hsa034200.75086066
61MAPK signaling pathway_Homo sapiens_hsa040100.74890541
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74819515
63Type II diabetes mellitus_Homo sapiens_hsa049300.73609757
64mRNA surveillance pathway_Homo sapiens_hsa030150.72007681
65DNA replication_Homo sapiens_hsa030300.71428347
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70235480
67PPAR signaling pathway_Homo sapiens_hsa033200.70094374
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69326778
69Hedgehog signaling pathway_Homo sapiens_hsa043400.67925851
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67819196
71One carbon pool by folate_Homo sapiens_hsa006700.66561204
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64253138
73VEGF signaling pathway_Homo sapiens_hsa043700.64159829
74Basal cell carcinoma_Homo sapiens_hsa052170.62646525
75FoxO signaling pathway_Homo sapiens_hsa040680.62302878
76Circadian entrainment_Homo sapiens_hsa047130.61836017
77Folate biosynthesis_Homo sapiens_hsa007900.61637120
78Hippo signaling pathway_Homo sapiens_hsa043900.61465316
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60286418
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59947432
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59306315
82Oocyte meiosis_Homo sapiens_hsa041140.59226071
83Gap junction_Homo sapiens_hsa045400.58070528
84Proteoglycans in cancer_Homo sapiens_hsa052050.56771801
85Cell cycle_Homo sapiens_hsa041100.55669644
86Olfactory transduction_Homo sapiens_hsa047400.55514581
87Long-term depression_Homo sapiens_hsa047300.54345391
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53797160
89beta-Alanine metabolism_Homo sapiens_hsa004100.52296017
90Alzheimers disease_Homo sapiens_hsa050100.52096645
91Purine metabolism_Homo sapiens_hsa002300.51264919
92Glioma_Homo sapiens_hsa052140.50726381
93Mismatch repair_Homo sapiens_hsa034300.50504126
94Salivary secretion_Homo sapiens_hsa049700.50358810
95Notch signaling pathway_Homo sapiens_hsa043300.49793774
96Sulfur relay system_Homo sapiens_hsa041220.49689281
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49406008
98Bladder cancer_Homo sapiens_hsa052190.49349632
99Small cell lung cancer_Homo sapiens_hsa052220.49224616
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47761213
101Endometrial cancer_Homo sapiens_hsa052130.47082393
102Vitamin B6 metabolism_Homo sapiens_hsa007500.46312857
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44946110
104cAMP signaling pathway_Homo sapiens_hsa040240.44815089
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44491303
106Wnt signaling pathway_Homo sapiens_hsa043100.44382492
107HIF-1 signaling pathway_Homo sapiens_hsa040660.43514429
108Cholinergic synapse_Homo sapiens_hsa047250.43211077
109Melanogenesis_Homo sapiens_hsa049160.42600567
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42537130
111Bile secretion_Homo sapiens_hsa049760.42297412
112Huntingtons disease_Homo sapiens_hsa050160.40868695
113Renal cell carcinoma_Homo sapiens_hsa052110.40838548
114Chronic myeloid leukemia_Homo sapiens_hsa052200.40823322
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40719215
116ECM-receptor interaction_Homo sapiens_hsa045120.39913806
117Pancreatic secretion_Homo sapiens_hsa049720.39105584
118ErbB signaling pathway_Homo sapiens_hsa040120.38632369
119Non-small cell lung cancer_Homo sapiens_hsa052230.37928106
120Tyrosine metabolism_Homo sapiens_hsa003500.37646241
121Butanoate metabolism_Homo sapiens_hsa006500.37479789
122Non-homologous end-joining_Homo sapiens_hsa034500.37431700
123TGF-beta signaling pathway_Homo sapiens_hsa043500.37157110
124Base excision repair_Homo sapiens_hsa034100.37154701
125Long-term potentiation_Homo sapiens_hsa047200.36570483
126Fatty acid elongation_Homo sapiens_hsa000620.36375140
127Inositol phosphate metabolism_Homo sapiens_hsa005620.36023444
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35323659
129Selenocompound metabolism_Homo sapiens_hsa004500.34589961
130Choline metabolism in cancer_Homo sapiens_hsa052310.34552501
131Parkinsons disease_Homo sapiens_hsa050120.33698918
132Glutamatergic synapse_Homo sapiens_hsa047240.33577514
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31752354
134Morphine addiction_Homo sapiens_hsa050320.31435758
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28635919
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.28529758
137MicroRNAs in cancer_Homo sapiens_hsa052060.27756160
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25647088
139ABC transporters_Homo sapiens_hsa020100.25360389

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