PHF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by mental retardation, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.63682293
2nuclear pore complex assembly (GO:0051292)4.89014029
3DNA unwinding involved in DNA replication (GO:0006268)4.87876363
4protein localization to chromosome, centromeric region (GO:0071459)4.61066879
5nuclear pore organization (GO:0006999)4.50111810
6DNA replication checkpoint (GO:0000076)4.35914345
7mitotic chromosome condensation (GO:0007076)4.34512536
8regulation of nuclear cell cycle DNA replication (GO:0033262)4.28610515
9DNA replication initiation (GO:0006270)4.26184571
10sister chromatid segregation (GO:0000819)4.23271040
11mitotic sister chromatid segregation (GO:0000070)4.19279704
12mitotic sister chromatid cohesion (GO:0007064)4.07478081
13DNA replication-dependent nucleosome organization (GO:0034723)4.06220760
14DNA replication-dependent nucleosome assembly (GO:0006335)4.06220760
15dosage compensation (GO:0007549)3.93859573
16polyketide metabolic process (GO:0030638)3.79613004
17doxorubicin metabolic process (GO:0044598)3.79613004
18daunorubicin metabolic process (GO:0044597)3.79613004
19DNA strand elongation involved in DNA replication (GO:0006271)3.76626291
20pore complex assembly (GO:0046931)3.75286956
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.68113237
22negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.67649292
23negative regulation of cell cycle G2/M phase transition (GO:1902750)3.66433772
24DNA strand elongation (GO:0022616)3.66234488
25regulation of telomere maintenance via telomerase (GO:0032210)3.62750295
26kinetochore organization (GO:0051383)3.61975611
27mitotic recombination (GO:0006312)3.61729834
28DNA duplex unwinding (GO:0032508)3.56954216
29DNA geometric change (GO:0032392)3.55118042
30telomere maintenance via semi-conservative replication (GO:0032201)3.54641407
31positive regulation of DNA-dependent DNA replication (GO:2000105)3.49435210
32attachment of spindle microtubules to kinetochore (GO:0008608)3.47886476
33DNA replication-independent nucleosome organization (GO:0034724)3.45485985
34DNA replication-independent nucleosome assembly (GO:0006336)3.45485985
35telomere maintenance via recombination (GO:0000722)3.36899663
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36725775
37regulation of centriole replication (GO:0046599)3.35895165
38regulation of helicase activity (GO:0051095)3.35532885
39CENP-A containing nucleosome assembly (GO:0034080)3.34864723
40resolution of meiotic recombination intermediates (GO:0000712)3.32166464
41DNA ligation (GO:0006266)3.30811729
42DNA damage response, detection of DNA damage (GO:0042769)3.30012583
43mitotic nuclear envelope disassembly (GO:0007077)3.28404261
44chromatin remodeling at centromere (GO:0031055)3.24857177
45chromatin assembly or disassembly (GO:0006333)3.20511759
46DNA topological change (GO:0006265)3.16904384
47protein localization to chromosome (GO:0034502)3.16884443
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14820371
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.14820371
50pre-miRNA processing (GO:0031054)3.13997892
51chromatin assembly (GO:0031497)3.07835821
52DNA conformation change (GO:0071103)3.07436386
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.05921433
54establishment of integrated proviral latency (GO:0075713)3.05603654
55meiotic chromosome segregation (GO:0045132)3.04887037
56regulation of DNA endoreduplication (GO:0032875)3.04320960
57regulation of telomere maintenance (GO:0032204)3.04251479
58nuclear envelope disassembly (GO:0051081)3.03393291
59membrane disassembly (GO:0030397)3.03393291
60regulation of centrosome cycle (GO:0046605)3.01279551
61regulation of mitotic spindle checkpoint (GO:1903504)3.00091178
62regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00091178
63mitotic metaphase plate congression (GO:0007080)2.99639942
64rRNA transcription (GO:0009303)2.99580608
65ATP-dependent chromatin remodeling (GO:0043044)2.98643384
66centriole replication (GO:0007099)2.96759715
67mitotic spindle checkpoint (GO:0071174)2.95450209
68interferon-gamma production (GO:0032609)2.94517231
69spindle assembly checkpoint (GO:0071173)2.93999315
70histone H4-K8 acetylation (GO:0043982)2.93931434
71histone H4-K5 acetylation (GO:0043981)2.93931434
72negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92212259
73regulation of double-strand break repair (GO:2000779)2.90801987
74kinetochore assembly (GO:0051382)2.90128877
75double-strand break repair via nonhomologous end joining (GO:0006303)2.89776229
76non-recombinational repair (GO:0000726)2.89776229
77chromosome condensation (GO:0030261)2.88788459
78telomere maintenance via telomere lengthening (GO:0010833)2.88726428
79negative regulation of RNA splicing (GO:0033119)2.88049692
80RNA stabilization (GO:0043489)2.87551234
81mRNA stabilization (GO:0048255)2.87551234
82chromosome segregation (GO:0007059)2.87476981
83spindle checkpoint (GO:0031577)2.87305857
84negative regulation of DNA recombination (GO:0045910)2.85956532
85mismatch repair (GO:0006298)2.81194348
86metaphase plate congression (GO:0051310)2.79657677
87regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.78110423
88histone exchange (GO:0043486)2.77868549
89regulation of double-strand break repair via homologous recombination (GO:0010569)2.77410181
90regulation of mitotic sister chromatid separation (GO:0010965)2.77024835
91regulation of mitotic sister chromatid segregation (GO:0033047)2.77024835
92regulation of sister chromatid segregation (GO:0033045)2.77024835
93regulation of sister chromatid cohesion (GO:0007063)2.76373361
94pyrimidine nucleobase catabolic process (GO:0006208)2.75883747
95negative regulation of telomere maintenance (GO:0032205)2.75399278
96heterochromatin organization (GO:0070828)2.75351703
97regulation of centrosome duplication (GO:0010824)2.75226169
98microtubule depolymerization (GO:0007019)2.74515441
99maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74187740
100regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.74024096
101negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.73935874
102negative regulation of sister chromatid segregation (GO:0033046)2.73935874
103negative regulation of mitotic sister chromatid separation (GO:2000816)2.73935874
104negative regulation of mitotic sister chromatid segregation (GO:0033048)2.73935874
105replication fork processing (GO:0031297)2.73383778
106negative regulation of epidermis development (GO:0045683)2.73001406
107mitotic spindle assembly checkpoint (GO:0007094)2.72556129
108DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.72371198
109presynaptic membrane assembly (GO:0097105)2.72209720
110DNA double-strand break processing (GO:0000729)2.72076441
111regulation of chromosome segregation (GO:0051983)2.72006878
112negative regulation of chromosome segregation (GO:0051985)2.71297760
113formation of translation preinitiation complex (GO:0001731)2.70699833
114telomere maintenance via telomerase (GO:0007004)2.69859575
115regulation of mitotic metaphase/anaphase transition (GO:0030071)2.69445145
116translesion synthesis (GO:0019985)2.68955999
117negative regulation of telomerase activity (GO:0051974)2.68788903
118DNA damage response, signal transduction resulting in transcription (GO:0042772)2.68748964
119spermatid nucleus differentiation (GO:0007289)2.68721099
120negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.67115783
121postreplication repair (GO:0006301)2.66683412
122DNA packaging (GO:0006323)2.66594262
123protein-DNA complex disassembly (GO:0032986)2.66528599
124nucleosome disassembly (GO:0006337)2.66528599
125regulation of DNA-dependent DNA replication (GO:0090329)2.66339460
126negative regulation of DNA-dependent DNA replication (GO:2000104)2.63584817
127mitotic G2/M transition checkpoint (GO:0044818)2.63370884
128purine nucleobase biosynthetic process (GO:0009113)2.63055845
129regulation of development, heterochronic (GO:0040034)2.58168938
130neuronal stem cell maintenance (GO:0097150)2.57322896
131intraciliary transport (GO:0042073)2.54600571
132mitotic spindle organization (GO:0007052)2.54161153
133neuron fate determination (GO:0048664)2.54070256
134positive regulation of histone H3-K4 methylation (GO:0051571)2.50320799
135histone-serine phosphorylation (GO:0035404)2.49159908
136forebrain neuron differentiation (GO:0021879)2.47873039
137DNA damage induced protein phosphorylation (GO:0006975)2.47770935
138positive regulation of cell cycle checkpoint (GO:1901978)2.46522557
139RNA-dependent DNA replication (GO:0006278)2.45841259
140exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43455139
141histone H2A acetylation (GO:0043968)2.43066316
142establishment of chromosome localization (GO:0051303)2.41810274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human4.90289637
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.78182515
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.58169627
4* TP63_19390658_ChIP-ChIP_HaCaT_Human3.27615146
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.23301333
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.57547111
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.54320478
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.40586956
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33842067
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31442411
11EWS_26573619_Chip-Seq_HEK293_Human2.30147254
12FUS_26573619_Chip-Seq_HEK293_Human2.29625976
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28304710
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26993495
15* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24752695
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20952928
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.20797008
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.20698874
19MYC_22102868_ChIP-Seq_BL_Human2.11879080
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09210898
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08117425
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05025456
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04124805
24TAF15_26573619_Chip-Seq_HEK293_Human2.01124506
25E2F7_22180533_ChIP-Seq_HELA_Human11.1311944
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99962595
27IGF1R_20145208_ChIP-Seq_DFB_Human1.96071797
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.93977029
29AR_21909140_ChIP-Seq_LNCAP_Human1.92014099
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90408715
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89702491
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87709467
33ZNF274_21170338_ChIP-Seq_K562_Hela1.86510647
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83490689
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82391529
36FOXP3_21729870_ChIP-Seq_TREG_Human1.81749912
37VDR_23849224_ChIP-Seq_CD4+_Human1.79798417
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77589911
39CIITA_25753668_ChIP-Seq_RAJI_Human1.77501611
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.74671007
41XRN2_22483619_ChIP-Seq_HELA_Human1.72484774
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71374310
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71374310
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71374310
45* ELK1_19687146_ChIP-ChIP_HELA_Human1.71324466
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71208481
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68640735
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68494150
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63380236
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63043436
51TTF2_22483619_ChIP-Seq_HELA_Human1.57823310
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53472303
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52631646
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51374208
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49117450
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.48556739
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48391102
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46422296
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.45364162
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45231551
61VDR_22108803_ChIP-Seq_LS180_Human1.40432314
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40022106
63P300_19829295_ChIP-Seq_ESCs_Human1.39728694
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39473672
65GBX2_23144817_ChIP-Seq_PC3_Human1.38179776
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37768223
67IRF1_19129219_ChIP-ChIP_H3396_Human1.35044300
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.34868908
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33983792
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32392518
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30643914
72GABP_19822575_ChIP-Seq_HepG2_Human1.29542678
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.28942134
74KDM5A_27292631_Chip-Seq_BREAST_Human1.27677666
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26573553
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25683316
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25486414
78EZH2_22144423_ChIP-Seq_EOC_Human1.25354719
79DCP1A_22483619_ChIP-Seq_HELA_Human1.24940298
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24699641
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24068503
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23515480
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23345632
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22992368
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21589444
86* RNF2_27304074_Chip-Seq_NSC_Mouse1.20466792
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15923357
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15308059
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13982370
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13661524
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13469990
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13125698
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11870671
94* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10864939
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09162434
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08827537
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08441876
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08084319
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07425258
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06004012
101YY1_21170310_ChIP-Seq_MESCs_Mouse1.05441384
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04665380
103SOX9_26525672_Chip-Seq_HEART_Mouse1.04333211
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04131810
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03795416
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.02089020
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01203918
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00951494
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00913406
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00568424
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00094326
112* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99794075
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99544364
114MYC_18940864_ChIP-ChIP_HL60_Human0.99394953
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98167198
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96741662
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96662337
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95333319
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.94674780
120TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94482521
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93709985
122TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92517772
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92403997
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92210284
125SMAD3_21741376_ChIP-Seq_EPCs_Human0.90630050
126CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90288883
127BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90085885
128MYB_26560356_Chip-Seq_TH2_Human0.89514717
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88598094
130SPI1_23547873_ChIP-Seq_NB4_Human0.87216924
131NANOG_16153702_ChIP-ChIP_HESCs_Human0.87097182
132NANOG_21062744_ChIP-ChIP_HESCs_Human0.87038624
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86797829
134KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85890153
135FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85832550
136TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85434989
137NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85299723
138SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84610240
139TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84319704
140* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83908975
141MYB_26560356_Chip-Seq_TH1_Human0.83680327
142STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.83199448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.32833759
2MP0010094_abnormal_chromosome_stability3.81496399
3MP0003077_abnormal_cell_cycle3.05308090
4MP0004957_abnormal_blastocyst_morpholog3.04840940
5MP0003111_abnormal_nucleus_morphology2.94524459
6MP0006292_abnormal_olfactory_placode2.83538368
7MP0002396_abnormal_hematopoietic_system2.75810423
8MP0003121_genomic_imprinting2.75030034
9MP0003693_abnormal_embryo_hatching2.62015238
10MP0008058_abnormal_DNA_repair2.56732841
11MP0008007_abnormal_cellular_replicative2.46548258
12MP0003787_abnormal_imprinting2.33764210
13MP0003890_abnormal_embryonic-extraembry2.31308018
14MP0005394_taste/olfaction_phenotype2.19125180
15MP0005499_abnormal_olfactory_system2.19125180
16MP0010352_gastrointestinal_tract_polyps2.16187475
17MP0003123_paternal_imprinting2.13404245
18MP0008789_abnormal_olfactory_epithelium2.02838118
19MP0000350_abnormal_cell_proliferation1.99710953
20MP0001529_abnormal_vocalization1.93806557
21MP0008932_abnormal_embryonic_tissue1.90030302
22MP0000778_abnormal_nervous_system1.84906003
23MP0010030_abnormal_orbit_morphology1.78254855
24MP0009697_abnormal_copulation1.77586837
25MP0003315_abnormal_perineum_morphology1.74850044
26MP0003880_abnormal_central_pattern1.68744301
27MP0001672_abnormal_embryogenesis/_devel1.67221590
28MP0005380_embryogenesis_phenotype1.67221590
29MP0000490_abnormal_crypts_of1.67211422
30MP0003122_maternal_imprinting1.65346096
31MP0003136_yellow_coat_color1.65184914
32MP0003763_abnormal_thymus_physiology1.64149351
33MP0004808_abnormal_hematopoietic_stem1.61069770
34MP0001293_anophthalmia1.59334640
35MP0003984_embryonic_growth_retardation1.53303839
36MP0006072_abnormal_retinal_apoptosis1.52738710
37MP0002088_abnormal_embryonic_growth/wei1.52073713
38MP0008995_early_reproductive_senescence1.51157989
39MP0002234_abnormal_pharynx_morphology1.49205590
40MP0008877_abnormal_DNA_methylation1.48899003
41MP0002697_abnormal_eye_size1.46750467
42MP0003567_abnormal_fetal_cardiomyocyte1.45273825
43MP0002085_abnormal_embryonic_tissue1.43022140
44MP0005075_abnormal_melanosome_morpholog1.42977616
45MP0002822_catalepsy1.41723734
46MP0002084_abnormal_developmental_patter1.38100155
47MP0006276_abnormal_autonomic_nervous1.37298722
48MP0003938_abnormal_ear_development1.35113750
49MP0001730_embryonic_growth_arrest1.35098775
50MP0004133_heterotaxia1.34181152
51MP0004264_abnormal_extraembryonic_tissu1.31825629
52MP0001697_abnormal_embryo_size1.31821123
53MP0000569_abnormal_digit_pigmentation1.31498429
54MP0000703_abnormal_thymus_morphology1.28438496
55MP0002398_abnormal_bone_marrow1.27107548
56MP0003718_maternal_effect1.26907986
57MP0004197_abnormal_fetal_growth/weight/1.25194576
58MP0000049_abnormal_middle_ear1.24660186
59MP0003937_abnormal_limbs/digits/tail_de1.21020441
60MP0000537_abnormal_urethra_morphology1.20115301
61MP0000313_abnormal_cell_death1.19581319
62MP0005248_abnormal_Harderian_gland1.18126189
63MP0002086_abnormal_extraembryonic_tissu1.17685455
64MP0002009_preneoplasia1.17061860
65MP0002019_abnormal_tumor_incidence1.13616734
66MP0010307_abnormal_tumor_latency1.13339374
67MP0002932_abnormal_joint_morphology1.12369740
68MP0002938_white_spotting1.12223441
69MP0000647_abnormal_sebaceous_gland1.10356425
70MP0005187_abnormal_penis_morphology1.10142341
71MP0000566_synostosis1.10035441
72MP0002233_abnormal_nose_morphology1.09389177
73MP0002080_prenatal_lethality1.08524174
74MP0001984_abnormal_olfaction1.08295846
75MP0002092_abnormal_eye_morphology1.07914688
76MP0005391_vision/eye_phenotype1.07102433
77MP0003221_abnormal_cardiomyocyte_apopto1.06636043
78MP0003786_premature_aging1.06427454
79MP0000678_abnormal_parathyroid_gland1.06316502
80MP0002653_abnormal_ependyma_morphology1.04830519
81MP0002102_abnormal_ear_morphology1.04636732
82MP0005253_abnormal_eye_physiology1.04587170
83MP0002751_abnormal_autonomic_nervous1.03927954
84MP0003935_abnormal_craniofacial_develop1.03912962
85MP0009053_abnormal_anal_canal1.03640978
86MP0003755_abnormal_palate_morphology1.02504006
87MP0000955_abnormal_spinal_cord1.02397329
88MP0000428_abnormal_craniofacial_morphol1.01390813
89MP0002184_abnormal_innervation0.99395317
90MP0005671_abnormal_response_to0.99159138
91MP0002722_abnormal_immune_system0.98866196
92MP0000689_abnormal_spleen_morphology0.98763915
93MP0001286_abnormal_eye_development0.97684834
94MP0009672_abnormal_birth_weight0.96643755
95MP0003942_abnormal_urinary_system0.96600268
96MP0001800_abnormal_humoral_immune0.95976806
97MP0005171_absent_coat_pigmentation0.95959690
98MP0002114_abnormal_axial_skeleton0.95894386
99MP0002152_abnormal_brain_morphology0.94546569
100MP0002638_abnormal_pupillary_reflex0.94511535
101MP0009703_decreased_birth_body0.93203074
102MP0003861_abnormal_nervous_system0.92028565
103MP0000432_abnormal_head_morphology0.91182391
104MP0001835_abnormal_antigen_presentation0.90848551
105MP0003119_abnormal_digestive_system0.89354202
106MP0005645_abnormal_hypothalamus_physiol0.88476745
107MP0009333_abnormal_splenocyte_physiolog0.88167517
108MP0001929_abnormal_gametogenesis0.87989193
109MP0000716_abnormal_immune_system0.87236621
110MP0004811_abnormal_neuron_physiology0.86650656
111MP0002429_abnormal_blood_cell0.85531194
112MP0000631_abnormal_neuroendocrine_gland0.85370525
113MP0001188_hyperpigmentation0.84800439
114MP0003011_delayed_dark_adaptation0.84010739
115MP0002116_abnormal_craniofacial_bone0.83723439
116MP0002752_abnormal_somatic_nervous0.83485755
117MP0002277_abnormal_respiratory_mucosa0.80874366
118MP0003385_abnormal_body_wall0.80857955
119MP0000653_abnormal_sex_gland0.80416528
120MP0009250_abnormal_appendicular_skeleto0.79736790
121MP0005195_abnormal_posterior_eye0.79028254
122MP0002210_abnormal_sex_determination0.77546273
123MP0001299_abnormal_eye_distance/0.77043243
124MP0004142_abnormal_muscle_tone0.76913653
125MP0001119_abnormal_female_reproductive0.76883725
126MP0002420_abnormal_adaptive_immunity0.74646049
127MP0001545_abnormal_hematopoietic_system0.73333684
128MP0005397_hematopoietic_system_phenotyp0.73333684
129MP0001819_abnormal_immune_cell0.73322536
130MP0002095_abnormal_skin_pigmentation0.72828570
131MP0002111_abnormal_tail_morphology0.71625939
132MP0002177_abnormal_outer_ear0.70904840
133MP0001145_abnormal_male_reproductive0.70605076
134MP0002081_perinatal_lethality0.70115224
135MP0005389_reproductive_system_phenotype0.69848431
136MP0002452_abnormal_antigen_presenting0.69307430
137MP0002160_abnormal_reproductive_system0.68628766

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.08553482
2Chromsome breakage (HP:0040012)4.00984436
3Bilateral microphthalmos (HP:0007633)3.80595398
4Volvulus (HP:0002580)3.40075555
5Nephroblastoma (Wilms tumor) (HP:0002667)3.33708533
6Cortical dysplasia (HP:0002539)3.31681843
7Abnormal lung lobation (HP:0002101)3.24458148
8Embryonal renal neoplasm (HP:0011794)3.14711296
9Hypochromic microcytic anemia (HP:0004840)3.13358371
10Meckel diverticulum (HP:0002245)3.07855943
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.04490486
12Abnormality of chromosome stability (HP:0003220)3.03140572
13Medulloblastoma (HP:0002885)2.96496923
14Abnormality of the ileum (HP:0001549)2.91932564
15Hepatoblastoma (HP:0002884)2.90523162
16Ependymoma (HP:0002888)2.87190268
17Colon cancer (HP:0003003)2.84777496
18Myelodysplasia (HP:0002863)2.72635723
19Rhabdomyosarcoma (HP:0002859)2.72470189
20Short 4th metacarpal (HP:0010044)2.70887676
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.70887676
22Abnormality of the preputium (HP:0100587)2.67240106
23Increased nuchal translucency (HP:0010880)2.64941004
24Small intestinal stenosis (HP:0012848)2.61749156
25Duodenal stenosis (HP:0100867)2.61749156
26Septo-optic dysplasia (HP:0100842)2.61690678
27Birth length less than 3rd percentile (HP:0003561)2.59842175
28Bifid tongue (HP:0010297)2.46876727
29Neoplasm of striated muscle (HP:0009728)2.45218012
30Abnormality of chromosome segregation (HP:0002916)2.43879420
31Reticulocytopenia (HP:0001896)2.41272303
32Aplasia/Hypoplasia of the sternum (HP:0006714)2.40753057
33Rib fusion (HP:0000902)2.40118123
34Renal duplication (HP:0000075)2.36705829
35Atresia of the external auditory canal (HP:0000413)2.36527464
36Patellar aplasia (HP:0006443)2.36140596
37Abnormality of the astrocytes (HP:0100707)2.33512094
38Astrocytoma (HP:0009592)2.33512094
39Aplasia/Hypoplasia of the patella (HP:0006498)2.26209836
40Intestinal atresia (HP:0011100)2.25484940
41Ectopic kidney (HP:0000086)2.23628863
42Esophageal atresia (HP:0002032)2.22088842
43Oligodactyly (hands) (HP:0001180)2.21868526
44Medial flaring of the eyebrow (HP:0010747)2.18116026
45Aplastic anemia (HP:0001915)2.18107732
46Degeneration of anterior horn cells (HP:0002398)2.16965326
47Abnormality of the anterior horn cell (HP:0006802)2.16965326
48Abnormality of the carotid arteries (HP:0005344)2.16775258
49Gastrointestinal atresia (HP:0002589)2.16399491
50Congenital primary aphakia (HP:0007707)2.16122799
51Abnormal number of incisors (HP:0011064)2.14498742
52Gait imbalance (HP:0002141)2.13487578
53Pancreatic cysts (HP:0001737)2.10351214
54Sloping forehead (HP:0000340)2.10279684
55Supernumerary spleens (HP:0009799)2.10271075
56Combined immunodeficiency (HP:0005387)2.08561327
57Abnormality of the phalanges of the hallux (HP:0010057)2.08353280
58Abnormality of midbrain morphology (HP:0002418)2.08284496
59Molar tooth sign on MRI (HP:0002419)2.08284496
60Abnormality of the labia minora (HP:0012880)2.06660543
61True hermaphroditism (HP:0010459)2.06234294
62Abnormality of the intervertebral disk (HP:0005108)2.06225972
63Genital tract atresia (HP:0001827)2.05814287
64Vaginal atresia (HP:0000148)2.05409894
65Abnormality of the duodenum (HP:0002246)2.03907176
66Papillary thyroid carcinoma (HP:0002895)2.02192130
67Impulsivity (HP:0100710)2.01696409
68Atrophy/Degeneration involving motor neurons (HP:0007373)2.00161966
69Nephrogenic diabetes insipidus (HP:0009806)1.99857006
70Short middle phalanx of the 5th finger (HP:0004220)1.99560084
71Bone marrow hypocellularity (HP:0005528)1.99358740
72Tented upper lip vermilion (HP:0010804)1.98136738
73Clubbing of toes (HP:0100760)1.97050787
74Pancreatic fibrosis (HP:0100732)1.96968982
75Poor coordination (HP:0002370)1.96106482
76Glioma (HP:0009733)1.96002101
77Selective tooth agenesis (HP:0001592)1.93160934
78Preaxial hand polydactyly (HP:0001177)1.92630688
79Embryonal neoplasm (HP:0002898)1.92352571
80Abnormality of the 4th metacarpal (HP:0010012)1.91913674
81Oligodactyly (HP:0012165)1.91685696
82Hypoplastic pelvis (HP:0008839)1.91586326
83Absent septum pellucidum (HP:0001331)1.91490123
84Abnormality of the septum pellucidum (HP:0007375)1.91249246
85Preauricular skin tag (HP:0000384)1.91004302
86Anophthalmia (HP:0000528)1.90898476
87Stenosis of the external auditory canal (HP:0000402)1.90050019
88Optic nerve hypoplasia (HP:0000609)1.89679562
89Skin tags (HP:0010609)1.87500094
90Abnormality of the fingertips (HP:0001211)1.86335735
91Hyperglycinemia (HP:0002154)1.84460959
92Increased number of teeth (HP:0011069)1.83502592
93Cleft eyelid (HP:0000625)1.83361081
94Cutaneous melanoma (HP:0012056)1.82946406
95Multiple enchondromatosis (HP:0005701)1.82556241
96Hemivertebrae (HP:0002937)1.81108328
97High anterior hairline (HP:0009890)1.81104762
98Short 5th finger (HP:0009237)1.80058697
99Cafe-au-lait spot (HP:0000957)1.79608434
100Neoplasm of the oral cavity (HP:0100649)1.79394230
101Postaxial hand polydactyly (HP:0001162)1.78289423
102Prominent nose (HP:0000448)1.77276789
103* Micropenis (HP:0000054)1.77222760
104Facial cleft (HP:0002006)1.76445064
105Shawl scrotum (HP:0000049)1.74233900
106Proximal placement of thumb (HP:0009623)1.74133939
107Tracheoesophageal fistula (HP:0002575)1.74051572
108Absent radius (HP:0003974)1.74047358
109Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73507749
110Aplasia involving forearm bones (HP:0009822)1.72878147
111Absent forearm bone (HP:0003953)1.72878147
112Postaxial foot polydactyly (HP:0001830)1.72640798
113Lissencephaly (HP:0001339)1.71986862
114Broad palm (HP:0001169)1.71550681
115Pendular nystagmus (HP:0012043)1.71450742
116Nephronophthisis (HP:0000090)1.71097984
117Thyroid carcinoma (HP:0002890)1.70437198
118Optic nerve coloboma (HP:0000588)1.68795161
119Chronic hepatic failure (HP:0100626)1.68558896
120Absent frontal sinuses (HP:0002688)1.67910696
121Facial hemangioma (HP:0000329)1.67121706
122Cutis marmorata (HP:0000965)1.67041750
123Horseshoe kidney (HP:0000085)1.66587501
124Triphalangeal thumb (HP:0001199)1.65987716
125Amyotrophic lateral sclerosis (HP:0007354)1.65311527
126Deviation of the thumb (HP:0009603)1.64983073
127Drooling (HP:0002307)1.63612734
128Arteriovenous malformation (HP:0100026)1.63269371
129Cutaneous finger syndactyly (HP:0010554)1.63102425
130Deep philtrum (HP:0002002)1.62746425
131Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.62423791
132Gonadotropin excess (HP:0000837)1.62079007
133Hypochromic anemia (HP:0001931)1.61698873
134Broad alveolar ridges (HP:0000187)1.60570400
135Sclerocornea (HP:0000647)1.60292597
136Dandy-Walker malformation (HP:0001305)1.59860039
137Lymphoma (HP:0002665)1.59622365
138Decreased testicular size (HP:0008734)1.57665006
139IgG deficiency (HP:0004315)1.57123225
140Renal hypoplasia (HP:0000089)1.56700706
141Duplication of thumb phalanx (HP:0009942)1.56267520
142Neoplasm of the colon (HP:0100273)1.56152478
143Abnormality of the distal phalanx of the thumb (HP:0009617)1.55818999
144Abdominal situs inversus (HP:0003363)1.55365639
145Abnormality of abdominal situs (HP:0011620)1.55365639
146Agnosia (HP:0010524)1.55257320
147Congenital diaphragmatic hernia (HP:0000776)1.55238168
148Lip pit (HP:0100267)1.55173994
149Specific learning disability (HP:0001328)1.55067934
150Neoplasm of the adrenal cortex (HP:0100641)1.54969458
151Cutaneous syndactyly (HP:0012725)1.51987423
152Short tibia (HP:0005736)1.51959905
153Aganglionic megacolon (HP:0002251)1.51214344
154Aplasia/Hypoplasia of the tibia (HP:0005772)1.49669910
155Holoprosencephaly (HP:0001360)1.48321284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.21790016
2CDC74.46194621
3SRPK12.84421388
4TTK2.67422072
5CASK2.54120220
6TRIM282.45775817
7MAP3K42.37353827
8MKNK12.33980713
9WEE12.23500856
10MAP4K22.18508745
11NEK22.15062242
12BCR2.10638078
13WNK32.04972245
14GRK62.04331494
15CSF1R1.98120085
16STK101.95697617
17PASK1.90080815
18ACVR1B1.85268370
19CHEK21.81878114
20TAF11.80457824
21PNCK1.79845751
22PLK11.78196764
23PLK41.77299200
24CDK71.75143613
25TGFBR11.73261870
26MKNK21.67156347
27ATR1.66086392
28MAP2K71.59988511
29ADRBK21.57226702
30BUB11.56952652
31EIF2AK11.53239053
32NUAK11.52047157
33DYRK31.51219554
34TNIK1.50448407
35BRSK21.48312691
36GRK51.47414773
37AURKB1.47337075
38FGFR31.45932218
39TXK1.43110826
40VRK21.41647189
41CSNK1G11.40088535
42MAP3K101.38886391
43ERBB31.36974670
44CHEK11.36951310
45CSNK1G31.33286879
46TSSK61.30372886
47PLK31.29172805
48EIF2AK21.26801696
49CSNK1G21.26277155
50RPS6KB21.26035388
51CSNK1A1L1.25579713
52VRK11.24278126
53BMPR1B1.23062127
54CDK81.18584383
55EEF2K1.16307834
56MAP4K11.15557895
57STK38L1.14554129
58CCNB11.14477568
59SIK31.14392077
60CDK41.14198298
61YES11.11766665
62ATM1.08575554
63TLK11.07609886
64CLK11.06947727
65PLK21.05120932
66DYRK21.04434346
67BRSK11.03751241
68TGFBR21.00486828
69PBK1.00217527
70MAP3K90.97828669
71BRD40.97078916
72* CDK20.96183639
73MELK0.95644307
74SCYL20.94208380
75JAK30.93618159
76GRK10.90756320
77MATK0.89285329
78NTRK20.82314174
79CDK10.80223182
80EPHA40.79837880
81RPS6KA40.79574220
82EIF2AK30.78723051
83CDK30.75215719
84CDK60.75034167
85PAK40.74956219
86TYRO30.74578585
87ITK0.74090862
88CHUK0.72840691
89ALK0.70779807
90NEK10.70052760
91TAOK20.69836659
92AKT30.68731980
93FRK0.68630822
94KIT0.68164835
95LATS10.68100058
96MAPK130.65825837
97STK160.65721371
98HIPK20.64864382
99FGFR10.64464348
100MINK10.63889219
101FGFR20.62837114
102PIM10.62811910
103TEC0.62591180
104CDK190.61199860
105STK40.60683595
106AURKA0.59605158
107STK390.58798182
108BTK0.57364995
109BCKDK0.55264283
110EPHA30.54823636
111IRAK40.53648376
112NME10.52834469
113PRKCG0.52137032
114MAPK70.51490369
115CSNK1E0.51288767
116CAMK40.50772331
117ADRBK10.50683343
118EPHB20.50514407
119CDK180.49930322
120PRKDC0.47837020
121SYK0.46595210
122CDK140.45117753
123STK30.44467576
124UHMK10.44329562
125CDK150.44293450
126MAP3K80.44105021
127ERN10.44050245
128MAPK140.43632424
129CDK11A0.43130570
130OXSR10.41762143
131MAP3K60.41274280
132CAMK1G0.37989262
133SIK20.37777037
134AKT20.37503720
135DYRK1A0.36390733
136STK240.36202005
137NLK0.36155627
138ZAK0.36037350
139AKT10.34162892
140LYN0.34151764
141CSNK2A10.33883782
142CSNK1D0.33709885
143INSRR0.33612660
144LCK0.32146927
145RPS6KB10.31761149
146MARK10.31733444
147KSR10.30946626
148NME20.29975378
149CSNK2A20.29432608

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.15415470
2Mismatch repair_Homo sapiens_hsa034303.51340229
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06473565
4Base excision repair_Homo sapiens_hsa034102.93967079
5Spliceosome_Homo sapiens_hsa030402.89144992
6Cell cycle_Homo sapiens_hsa041102.89009166
7RNA transport_Homo sapiens_hsa030132.57316968
8Protein export_Homo sapiens_hsa030602.54532423
9Homologous recombination_Homo sapiens_hsa034402.50494297
10Fanconi anemia pathway_Homo sapiens_hsa034602.45602708
11Nucleotide excision repair_Homo sapiens_hsa034202.24935728
12mRNA surveillance pathway_Homo sapiens_hsa030152.16519958
13Non-homologous end-joining_Homo sapiens_hsa034502.14106224
14RNA degradation_Homo sapiens_hsa030182.00121784
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.97949444
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87031048
17One carbon pool by folate_Homo sapiens_hsa006701.86411308
18Propanoate metabolism_Homo sapiens_hsa006401.80229662
19RNA polymerase_Homo sapiens_hsa030201.74658946
20Primary immunodeficiency_Homo sapiens_hsa053401.70054267
21Steroid biosynthesis_Homo sapiens_hsa001001.69807038
22p53 signaling pathway_Homo sapiens_hsa041151.59780894
23Ribosome_Homo sapiens_hsa030101.55934381
24Basal transcription factors_Homo sapiens_hsa030221.50215836
25Pyrimidine metabolism_Homo sapiens_hsa002401.47579649
26Herpes simplex infection_Homo sapiens_hsa051681.47386216
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46677334
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30238833
29Proteasome_Homo sapiens_hsa030501.29377508
30Selenocompound metabolism_Homo sapiens_hsa004501.24257212
31MicroRNAs in cancer_Homo sapiens_hsa052061.23898372
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.23192478
33Colorectal cancer_Homo sapiens_hsa052101.22355318
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21769413
35Parkinsons disease_Homo sapiens_hsa050121.21674552
36Nicotine addiction_Homo sapiens_hsa050331.21044928
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18917203
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.18641424
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17418049
40Oxidative phosphorylation_Homo sapiens_hsa001901.15082152
41Viral carcinogenesis_Homo sapiens_hsa052031.14800477
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.14117160
43Systemic lupus erythematosus_Homo sapiens_hsa053221.09715221
44HTLV-I infection_Homo sapiens_hsa051661.09523544
45Thyroid cancer_Homo sapiens_hsa052161.07367089
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06836660
47Epstein-Barr virus infection_Homo sapiens_hsa051691.05898462
48Huntingtons disease_Homo sapiens_hsa050161.05335447
49Pyruvate metabolism_Homo sapiens_hsa006201.02746508
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01979789
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99005198
52Measles_Homo sapiens_hsa051620.98809723
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98315150
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97164290
55T cell receptor signaling pathway_Homo sapiens_hsa046600.94901643
56Viral myocarditis_Homo sapiens_hsa054160.94182604
57Autoimmune thyroid disease_Homo sapiens_hsa053200.91926826
58Allograft rejection_Homo sapiens_hsa053300.91758501
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91638917
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89504600
61Hepatitis B_Homo sapiens_hsa051610.88241746
62Basal cell carcinoma_Homo sapiens_hsa052170.87295965
63Antigen processing and presentation_Homo sapiens_hsa046120.87264946
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87185505
65Pancreatic cancer_Homo sapiens_hsa052120.86543720
66Chronic myeloid leukemia_Homo sapiens_hsa052200.86355424
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85225351
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83700186
69Small cell lung cancer_Homo sapiens_hsa052220.83496617
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82136648
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82007343
72Oocyte meiosis_Homo sapiens_hsa041140.81336284
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78926469
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77671691
75Butanoate metabolism_Homo sapiens_hsa006500.77495136
76Acute myeloid leukemia_Homo sapiens_hsa052210.77413032
77B cell receptor signaling pathway_Homo sapiens_hsa046620.77348311
78Biosynthesis of amino acids_Homo sapiens_hsa012300.75264740
79mTOR signaling pathway_Homo sapiens_hsa041500.74055877
80Non-small cell lung cancer_Homo sapiens_hsa052230.73295156
81Endometrial cancer_Homo sapiens_hsa052130.70891826
82Taste transduction_Homo sapiens_hsa047420.70745718
83Purine metabolism_Homo sapiens_hsa002300.70631788
84Pathways in cancer_Homo sapiens_hsa052000.69697235
85Influenza A_Homo sapiens_hsa051640.67364867
86Hematopoietic cell lineage_Homo sapiens_hsa046400.66367114
87Alcoholism_Homo sapiens_hsa050340.65613755
88Hippo signaling pathway_Homo sapiens_hsa043900.65274583
89Axon guidance_Homo sapiens_hsa043600.64527784
90Phototransduction_Homo sapiens_hsa047440.64508695
91Graft-versus-host disease_Homo sapiens_hsa053320.64434195
92Leishmaniasis_Homo sapiens_hsa051400.64107666
93Lysine degradation_Homo sapiens_hsa003100.64024737
94Apoptosis_Homo sapiens_hsa042100.63948589
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.63927531
96Legionellosis_Homo sapiens_hsa051340.61964997
97Fatty acid elongation_Homo sapiens_hsa000620.61779568
98Alzheimers disease_Homo sapiens_hsa050100.59682372
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59577580
100Notch signaling pathway_Homo sapiens_hsa043300.59106381
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56246309
102Folate biosynthesis_Homo sapiens_hsa007900.55702439
103Wnt signaling pathway_Homo sapiens_hsa043100.55167027
104Shigellosis_Homo sapiens_hsa051310.54692320
105Carbon metabolism_Homo sapiens_hsa012000.54097489
106Prostate cancer_Homo sapiens_hsa052150.53618517
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53072095
108TGF-beta signaling pathway_Homo sapiens_hsa043500.52579609
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.51930711
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.51494780
111Adherens junction_Homo sapiens_hsa045200.51106277
112Prolactin signaling pathway_Homo sapiens_hsa049170.50990099
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49398869
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48764490
115Hedgehog signaling pathway_Homo sapiens_hsa043400.47589052
116Vitamin B6 metabolism_Homo sapiens_hsa007500.46695447
117Asthma_Homo sapiens_hsa053100.45450402
118Cardiac muscle contraction_Homo sapiens_hsa042600.45089898
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44391821
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43778155
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40502954
122FoxO signaling pathway_Homo sapiens_hsa040680.40136143
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39189502
124Type I diabetes mellitus_Homo sapiens_hsa049400.39181807
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38683983
126Toxoplasmosis_Homo sapiens_hsa051450.38565851
127TNF signaling pathway_Homo sapiens_hsa046680.38107964
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36426325
129Fatty acid metabolism_Homo sapiens_hsa012120.36334981
130Metabolic pathways_Homo sapiens_hsa011000.35495462
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34428867
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34373950
133Olfactory transduction_Homo sapiens_hsa047400.34165016
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.34135447
135Proteoglycans in cancer_Homo sapiens_hsa052050.34115880
136Dopaminergic synapse_Homo sapiens_hsa047280.33544468
137GABAergic synapse_Homo sapiens_hsa047270.32717129
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31758549
139Arachidonic acid metabolism_Homo sapiens_hsa005900.30953645
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30433937
141Chemokine signaling pathway_Homo sapiens_hsa040620.29073775
142Hepatitis C_Homo sapiens_hsa051600.28262939
143Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26648600
144Melanogenesis_Homo sapiens_hsa049160.26363989
145Gap junction_Homo sapiens_hsa045400.24865678
146Circadian rhythm_Homo sapiens_hsa047100.23895500
147Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23844261
148Tight junction_Homo sapiens_hsa045300.22849225
149Peroxisome_Homo sapiens_hsa041460.20397024
150Melanoma_Homo sapiens_hsa052180.18341567
151Long-term depression_Homo sapiens_hsa047300.17845978
152Regulation of autophagy_Homo sapiens_hsa041400.17026747
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16794756
154Cocaine addiction_Homo sapiens_hsa050300.14339059
155Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.13867886
156Glutamatergic synapse_Homo sapiens_hsa047240.13477138

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