PHF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of histone deacetylation (GO:0031065)5.09845562
2regulation of gamma-delta T cell differentiation (GO:0045586)4.23227400
3positive regulation of gamma-delta T cell activation (GO:0046645)3.85669054
4cytoplasmic mRNA processing body assembly (GO:0033962)3.63561999
5regulation of gamma-delta T cell activation (GO:0046643)3.62380592
6insulin-like growth factor receptor signaling pathway (GO:0048009)3.56731213
7negative regulation of cell size (GO:0045792)3.35904796
8positive regulation of protein deacetylation (GO:0090312)3.34401379
9positive thymic T cell selection (GO:0045059)3.33784587
10negative regulation of fatty acid transport (GO:2000192)3.30534933
11peptidyl-lysine dimethylation (GO:0018027)3.24356221
12positive T cell selection (GO:0043368)3.21457650
13T cell selection (GO:0045058)3.04008289
14positive regulation of glycogen biosynthetic process (GO:0045725)3.03045329
15cytoskeletal anchoring at plasma membrane (GO:0007016)2.94023417
16glucocorticoid receptor signaling pathway (GO:0042921)2.89979558
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88131702
18protein localization to endosome (GO:0036010)2.87768294
19thymic T cell selection (GO:0045061)2.86639683
20growth hormone receptor signaling pathway (GO:0060396)2.86570993
21regulation of histone deacetylation (GO:0031063)2.83595870
22regulation of fatty acid beta-oxidation (GO:0031998)2.79862857
23natural killer cell differentiation (GO:0001779)2.79285365
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.75261294
25negative regulation of cell killing (GO:0031342)2.75261294
26NLS-bearing protein import into nucleus (GO:0006607)2.75203753
27V(D)J recombination (GO:0033151)2.74812637
28coronary vasculature morphogenesis (GO:0060977)2.74184946
29negative regulation of erythrocyte differentiation (GO:0045647)2.73202904
30plasma membrane repair (GO:0001778)2.70741915
31adherens junction assembly (GO:0034333)2.66892273
32cortical actin cytoskeleton organization (GO:0030866)2.63033959
33positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.62570685
34intracellular estrogen receptor signaling pathway (GO:0030520)2.62399240
35activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.59135484
36negative T cell selection (GO:0043383)2.55228471
37negative regulation of heart growth (GO:0061117)2.54847471
38negative regulation of cardiac muscle tissue growth (GO:0055022)2.54847471
39embryonic retina morphogenesis in camera-type eye (GO:0060059)2.53320925
40positive regulation of glycogen metabolic process (GO:0070875)2.53271508
41cellular response to monoamine stimulus (GO:0071868)2.51553717
42cellular response to catecholamine stimulus (GO:0071870)2.51553717
43cellular response to growth hormone stimulus (GO:0071378)2.51549708
44regulation of T-helper 2 cell differentiation (GO:0045628)2.51162184
45positive regulation of nuclease activity (GO:0032075)2.51103474
46germ cell migration (GO:0008354)2.50159569
47corticosteroid receptor signaling pathway (GO:0031958)2.49915625
48cerebellar granule cell differentiation (GO:0021707)2.49390904
49regulation of NFAT protein import into nucleus (GO:0051532)2.48868705
50vascular endothelial growth factor signaling pathway (GO:0038084)2.47971910
51positive regulation of blood vessel endothelial cell migration (GO:0043536)2.47329581
52response to muramyl dipeptide (GO:0032495)2.47298411
53focal adhesion assembly (GO:0048041)2.44748618
54cell-substrate adherens junction assembly (GO:0007045)2.44748618
55regulation of polysaccharide biosynthetic process (GO:0032885)2.43269665
56antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.42562728
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.42562728
58stress fiber assembly (GO:0043149)2.41603471
59positive regulation of myotube differentiation (GO:0010831)2.41538983
60regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.40799183
61cell-cell junction maintenance (GO:0045217)2.40113810
62negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.40110653
63regulation of ARF GTPase activity (GO:0032312)2.39790037
64regulation of ARF protein signal transduction (GO:0032012)2.39654485
65Peyers patch development (GO:0048541)2.38984142
66mucosal-associated lymphoid tissue development (GO:0048537)2.38984142
67regulation of histone H3-K27 methylation (GO:0061085)2.38515490
68positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.38450161
69positive regulation of Rap GTPase activity (GO:0032854)2.38170769
70positive regulation of fatty acid beta-oxidation (GO:0032000)2.38083170
71RNA stabilization (GO:0043489)2.35944909
72mRNA stabilization (GO:0048255)2.35944909
73regulation of p38MAPK cascade (GO:1900744)2.34967525
74nucleosome disassembly (GO:0006337)2.33716414
75protein-DNA complex disassembly (GO:0032986)2.33716414
76regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.33709707
77maternal placenta development (GO:0001893)2.33069847
78patterning of blood vessels (GO:0001569)2.32861646
79receptor catabolic process (GO:0032801)2.31968818
80cell-substrate junction assembly (GO:0007044)2.31864942
81regulation of protein deacetylation (GO:0090311)2.31356282
82Golgi transport vesicle coating (GO:0048200)2.31290980
83COPI coating of Golgi vesicle (GO:0048205)2.31290980
84JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.31187505
85heart morphogenesis (GO:0003007)2.30205589
86morphogenesis of an endothelium (GO:0003159)2.29783324
87endothelial tube morphogenesis (GO:0061154)2.29783324
88cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.29081427
89negative regulation of Ras protein signal transduction (GO:0046580)2.27995093
90activation of JUN kinase activity (GO:0007257)2.27744426
91negative thymic T cell selection (GO:0045060)2.26150108
92regulation of nuclease activity (GO:0032069)2.24937324
93regulation of interleukin-12 biosynthetic process (GO:0045075)2.24785480
94mitotic sister chromatid cohesion (GO:0007064)2.24384442
95embryonic camera-type eye morphogenesis (GO:0048596)2.24266984
96syncytium formation by plasma membrane fusion (GO:0000768)2.24148727
97mannose metabolic process (GO:0006013)2.23938960
98retrograde transport, vesicle recycling within Golgi (GO:0000301)2.23709863
99cardiac myofibril assembly (GO:0055003)2.22675590
100regulation of extracellular matrix disassembly (GO:0010715)2.22429665
101glial cell proliferation (GO:0014009)2.21140581
102negative regulation of inclusion body assembly (GO:0090084)2.20729213
103histone H3-K36 demethylation (GO:0070544)2.20377747
104cellular response to epinephrine stimulus (GO:0071872)2.20186590
105planar cell polarity pathway involved in neural tube closure (GO:0090179)2.20119071
106positive regulation of RNA splicing (GO:0033120)2.20084807
107epithelial cell differentiation involved in prostate gland development (GO:0060742)2.20026247
108regulation of somitogenesis (GO:0014807)2.19319976
109negative regulation of small GTPase mediated signal transduction (GO:0051058)2.18572258
110genitalia morphogenesis (GO:0035112)2.18564785
111response to fluid shear stress (GO:0034405)2.18185207
112regulation of cholesterol homeostasis (GO:2000188)2.17578954
113regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.17396290
114peptidyl-tyrosine autophosphorylation (GO:0038083)2.17279408
115negative regulation of myotube differentiation (GO:0010832)2.16029768
116regulation of glucose import in response to insulin stimulus (GO:2001273)2.15528322
117response to laminar fluid shear stress (GO:0034616)2.13825669
118negative regulation of glial cell proliferation (GO:0060253)2.12755286
119peptidyl-threonine modification (GO:0018210)2.12567526
120positive regulation of receptor recycling (GO:0001921)2.12339957
121myoblast fusion (GO:0007520)2.11913054
122camera-type eye morphogenesis (GO:0048593)2.11015669
123establishment of nucleus localization (GO:0040023)2.10941588
124antigen processing and presentation of endogenous antigen (GO:0019883)2.10644414
125negative regulation of nucleotide catabolic process (GO:0030812)2.10160939
126sexual reproduction (GO:0019953)2.10117730
127positive regulation by symbiont of host defense response (GO:0052509)2.09206826
128modulation by symbiont of host defense response (GO:0052031)2.09206826
129modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.09206826
130modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.09206826
131positive regulation by organism of defense response of other organism involved in symbiotic interact2.09206826
132modulation by symbiont of host immune response (GO:0052553)2.09206826
133sodium ion export (GO:0071436)2.08333819
134response to catecholamine (GO:0071869)2.08292559
135response to monoamine (GO:0071867)2.08292559
136semaphorin-plexin signaling pathway (GO:0071526)2.06784932
137cardiac muscle cell proliferation (GO:0060038)2.05381266
138macrophage activation involved in immune response (GO:0002281)2.04613996
139regulation of lipid kinase activity (GO:0043550)2.03729561
140protein targeting to plasma membrane (GO:0072661)2.02344502
141eye morphogenesis (GO:0048592)2.00230397
142negative regulation of granulocyte differentiation (GO:0030853)1.99162219
143germinal center formation (GO:0002467)1.98637657
144activation of protein kinase A activity (GO:0034199)1.98289746
145positive regulation of cellular amide metabolic process (GO:0034250)1.98243545
146embryonic eye morphogenesis (GO:0048048)1.98152719
147regulation of early endosome to late endosome transport (GO:2000641)1.97911194
148response to parathyroid hormone (GO:0071107)1.97633807
149regulation of phosphatidylinositol 3-kinase activity (GO:0043551)1.97630095
150peptidyl-threonine phosphorylation (GO:0018107)1.97553861
151positive regulation of Rab GTPase activity (GO:0032851)1.96349665
152regulation of Rab GTPase activity (GO:0032313)1.96349665
153histone H4 deacetylation (GO:0070933)1.95851598
154atrioventricular valve morphogenesis (GO:0003181)1.94407695
155signal complex assembly (GO:0007172)1.93682861
156G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)1.93255201
157cell migration in hindbrain (GO:0021535)1.90073289
158cell junction maintenance (GO:0034331)1.88933521
159cortical cytoskeleton organization (GO:0030865)1.88670121
160negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)1.87296727
161epithelial cell fate commitment (GO:0072148)1.87068033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.78361352
2MYC_22102868_ChIP-Seq_BL_Human3.57311849
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.22793793
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.18583375
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.82839495
6KDM2B_26808549_Chip-Seq_DND41_Human2.80544890
7* TCF7_22412390_ChIP-Seq_EML_Mouse2.78925759
8* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.59369941
9VDR_21846776_ChIP-Seq_THP-1_Human2.51711128
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44007260
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.42472943
12* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.40773369
13KDM2B_26808549_Chip-Seq_JURKAT_Human2.10048197
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.04323956
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.03759829
16UTX_26944678_Chip-Seq_JUKART_Human1.98893814
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96559459
18KDM2B_26808549_Chip-Seq_K562_Human1.96053616
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93267855
20DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.91594921
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90213878
22MAF_26560356_Chip-Seq_TH1_Human1.85120951
23* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.83046187
24LXR_22292898_ChIP-Seq_THP-1_Human1.81673356
25RUNX_20019798_ChIP-Seq_JUKART_Human1.79498590
26CLOCK_20551151_ChIP-Seq_293T_Human1.74688644
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73299034
28ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72426448
29EZH2_22144423_ChIP-Seq_EOC_Human1.71048757
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69824807
31VDR_24763502_ChIP-Seq_THP-1_Human1.67901187
32* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65806659
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64368846
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63097780
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62956178
36P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59745231
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57302616
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.56738056
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55058898
40NFIB_24661679_ChIP-Seq_LUNG_Mouse1.50616408
41TBX20_22080862_ChIP-Seq_HEART_Mouse1.50031465
42TBX20_22328084_ChIP-Seq_HEART_Mouse1.50031465
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48916483
44SCL_19346495_ChIP-Seq_HPC-7_Human1.48288887
45SPI1_23127762_ChIP-Seq_K562_Human1.45991536
46RACK7_27058665_Chip-Seq_MCF-7_Human1.45086720
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42067052
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42033090
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41820381
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41128420
51FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.37738797
52GATA1_19941826_ChIP-Seq_K562_Human1.35732389
53SMC4_20622854_ChIP-Seq_HELA_Human1.35397688
54MYB_26560356_Chip-Seq_TH2_Human1.33351763
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.33141791
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.31459774
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31260778
58CREB1_26743006_Chip-Seq_LNCaP_Human1.31074376
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29029817
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28826837
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28422396
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28422396
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27209845
64* RUNX1_27514584_Chip-Seq_MCF-7_Human1.27063838
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26459919
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25418106
67NCOR1_26117541_ChIP-Seq_K562_Human1.23235588
68MYB_26560356_Chip-Seq_TH1_Human1.22916047
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22810885
70* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22647122
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.22128558
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20942486
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.20821120
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20708570
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19878070
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19194644
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18779830
78* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18141707
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.17292116
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17065106
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.16617286
82CTCF_27219007_Chip-Seq_Bcells_Human1.13731586
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12577710
84ZNF263_19887448_ChIP-Seq_K562_Human1.12187337
85* DROSHA_22980978_ChIP-Seq_HELA_Human1.12045820
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11977430
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.10184731
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.09026980
89* SA1_27219007_Chip-Seq_ERYTHROID_Human1.08897670
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08697156
91TP63_17297297_ChIP-ChIP_HaCaT_Human1.06868363
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06369250
93BP1_19119308_ChIP-ChIP_Hs578T_Human1.05680425
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05511559
95FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05288836
96MAF_26560356_Chip-Seq_TH2_Human1.04865565
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.04330182
98SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03999756
99FOXA2_19822575_ChIP-Seq_HepG2_Human1.03774180
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03177842
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02865211
102NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02788534
103EZH2_27304074_Chip-Seq_ESCs_Mouse1.02258304
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02039618
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00751321
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98181822
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97935218
108PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97716304
109GATA3_27048872_Chip-Seq_THYMUS_Human0.97703032
110P68_20966046_ChIP-Seq_HELA_Human0.96653965
111CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96077870
112RING1B_27294783_Chip-Seq_NPCs_Mouse0.93589668
113RARB_27405468_Chip-Seq_BRAIN_Mouse0.93488080
114SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93327805
115TP63_22573176_ChIP-Seq_HFKS_Human0.92874749
116TP53_20018659_ChIP-ChIP_R1E_Mouse0.92020440
117ATF3_27146783_Chip-Seq_COLON_Human0.91818742
118TET1_21490601_ChIP-Seq_MESCs_Mouse0.91738214
119PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91655356
120TP53_22127205_ChIP-Seq_IMR90_Human0.91523694
121* GATA2_19941826_ChIP-Seq_K562_Human0.91355211
122UBF1/2_26484160_Chip-Seq_HMECs_Human0.91183037
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.90794289
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90163945
125GATA2_21666600_ChIP-Seq_HMVEC_Human0.89912025
126SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89715240
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89607066
128* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89175614
129TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.88798722
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88740290

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.88328096
2MP0003300_gastrointestinal_ulcer3.88141248
3MP0009278_abnormal_bone_marrow3.03996322
4MP0005076_abnormal_cell_differentiation2.86387335
5MP0008961_abnormal_basal_metabolism2.85547821
6MP0005451_abnormal_body_composition2.59179026
7MP0004859_abnormal_synaptic_plasticity2.48687848
8MP0005409_darkened_coat_color2.46852222
9MP0003303_peritoneal_inflammation2.42209299
10MP0001348_abnormal_lacrimal_gland2.11335212
11MP0002877_abnormal_melanocyte_morpholog2.10130685
12MP0000733_abnormal_muscle_development2.06906172
13MP0006054_spinal_hemorrhage2.02137157
14MP0001849_ear_inflammation1.95381261
15MP0004808_abnormal_hematopoietic_stem1.94634606
16MP0002249_abnormal_larynx_morphology1.89679008
17MP0002166_altered_tumor_susceptibility1.88808443
18MP0004858_abnormal_nervous_system1.88190530
19MP0010352_gastrointestinal_tract_polyps1.81979097
20MP0004130_abnormal_muscle_cell1.80526787
21MP0000003_abnormal_adipose_tissue1.76282886
22MP0003329_amyloid_beta_deposits1.75086672
23MP0003172_abnormal_lysosome_physiology1.74833417
24MP0003436_decreased_susceptibility_to1.72870317
25MP0004185_abnormal_adipocyte_glucose1.70644984
26MP0008438_abnormal_cutaneous_collagen1.68686972
27MP0003045_fibrosis1.66602938
28MP0003566_abnormal_cell_adhesion1.65364505
29MP0003279_aneurysm1.64839951
30MP0001879_abnormal_lymphatic_vessel1.63344223
31MP0004087_abnormal_muscle_fiber1.60564369
32MP0000569_abnormal_digit_pigmentation1.58154946
33MP0010630_abnormal_cardiac_muscle1.54640669
34MP0003690_abnormal_glial_cell1.53992794
35MP0005375_adipose_tissue_phenotype1.53852522
36MP0004510_myositis1.52937264
37MP0002909_abnormal_adrenal_gland1.51803363
38MP0002009_preneoplasia1.48581948
39MP0009780_abnormal_chondrocyte_physiolo1.44742837
40MP0000013_abnormal_adipose_tissue1.44642617
41MP0010368_abnormal_lymphatic_system1.44603089
42MP0000703_abnormal_thymus_morphology1.43891589
43MP0000751_myopathy1.43627053
44MP0000685_abnormal_immune_system1.42705891
45MP0003763_abnormal_thymus_physiology1.41408934
46MP0003091_abnormal_cell_migration1.37860807
47MP0003183_abnormal_peptide_metabolism1.37167580
48MP0005623_abnormal_meninges_morphology1.31892803
49MP0004947_skin_inflammation1.31626088
50MP0005503_abnormal_tendon_morphology1.30255772
51MP0005666_abnormal_adipose_tissue1.29821374
52MP0004381_abnormal_hair_follicle1.28609526
53MP0005423_abnormal_somatic_nervous1.27181287
54MP0005058_abnormal_lysosome_morphology1.26842104
55MP0004270_analgesia1.26237292
56MP0010234_abnormal_vibrissa_follicle1.26170605
57MP0003115_abnormal_respiratory_system1.25720969
58MP0003453_abnormal_keratinocyte_physiol1.25229005
59MP0005397_hematopoietic_system_phenotyp1.24472835
60MP0001545_abnormal_hematopoietic_system1.24472835
61MP0000678_abnormal_parathyroid_gland1.22545778
62MP0002925_abnormal_cardiovascular_devel1.21873522
63MP0003879_abnormal_hair_cell1.16698871
64MP0004233_abnormal_muscle_weight1.16224773
65MP0005187_abnormal_penis_morphology1.13575131
66MP0003724_increased_susceptibility_to1.12150734
67MP0000428_abnormal_craniofacial_morphol1.11571289
68MP0001958_emphysema1.11484136
69MP0003634_abnormal_glial_cell1.11061377
70MP0002396_abnormal_hematopoietic_system1.10970501
71MP0000759_abnormal_skeletal_muscle1.08350584
72MP0000266_abnormal_heart_morphology1.07665454
73MP0002896_abnormal_bone_mineralization1.07590789
74MP0004084_abnormal_cardiac_muscle1.07460240
75MP0008569_lethality_at_weaning1.07375220
76MP0002006_tumorigenesis1.06689322
77MP0004197_abnormal_fetal_growth/weight/1.06391132
78MP0006138_congestive_heart_failure1.06304430
79MP0000767_abnormal_smooth_muscle1.05877387
80MP0005248_abnormal_Harderian_gland1.04423981
81MP0001790_abnormal_immune_system1.03437393
82MP0005387_immune_system_phenotype1.03437393
83MP0001533_abnormal_skeleton_physiology1.03063855
84MP0002398_abnormal_bone_marrow1.01560967
85MP0002128_abnormal_blood_circulation1.00747617
86MP0008260_abnormal_autophagy1.00088522
87MP0002822_catalepsy0.99380935
88MP0002837_dystrophic_cardiac_calcinosis0.98645317
89MP0003283_abnormal_digestive_organ0.97201380
90MP0005275_abnormal_skin_tensile0.95910314
91MP0009703_decreased_birth_body0.95389794
92MP0001784_abnormal_fluid_regulation0.93632849
93MP0003935_abnormal_craniofacial_develop0.93632366
94MP0000747_muscle_weakness0.92909221
95MP0002928_abnormal_bile_duct0.92613293
96MP0001944_abnormal_pancreas_morphology0.92416245
97MP0003635_abnormal_synaptic_transmissio0.91431178
98MP0002234_abnormal_pharynx_morphology0.91277087
99MP0002106_abnormal_muscle_physiology0.90492534
100MP0001800_abnormal_humoral_immune0.89109498
101MP0001851_eye_inflammation0.88745231
102MP0009672_abnormal_birth_weight0.88237562
103MP0000537_abnormal_urethra_morphology0.88159417
104MP0002970_abnormal_white_adipose0.85296252
105MP0002998_abnormal_bone_remodeling0.84615986
106MP0003385_abnormal_body_wall0.84578665
107MP0003828_pulmonary_edema0.84253288
108MP0008770_decreased_survivor_rate0.83230065
109MP0005023_abnormal_wound_healing0.83204670
110MP0004036_abnormal_muscle_relaxation0.82775969
111MP0003191_abnormal_cellular_cholesterol0.82595129
112MP0005330_cardiomyopathy0.82081309
113MP0002933_joint_inflammation0.81905804
114MP0002063_abnormal_learning/memory/cond0.81819452
115MP0002332_abnormal_exercise_endurance0.81506326
116MP0002127_abnormal_cardiovascular_syste0.81068382
117MP0001270_distended_abdomen0.79848292
118MP0004272_abnormal_basement_membrane0.79290373
119MP0010155_abnormal_intestine_physiology0.77728465
120MP0000604_amyloidosis0.77254520
121MP0000681_abnormal_thyroid_gland0.77227648
122MP0009115_abnormal_fat_cell0.77098590
123MP0002971_abnormal_brown_adipose0.75096735
124MP0000750_abnormal_muscle_regeneration0.74859901
125MP0002722_abnormal_immune_system0.74626392
126MP0005670_abnormal_white_adipose0.74343904
127MP0001915_intracranial_hemorrhage0.74043930
128MP0005377_hearing/vestibular/ear_phenot0.73990557
129MP0003878_abnormal_ear_physiology0.73990557
130MP0005369_muscle_phenotype0.73976879
131MP0000778_abnormal_nervous_system0.73498822
132MP0001614_abnormal_blood_vessel0.73018499
133MP0005390_skeleton_phenotype0.72995141
134MP0002419_abnormal_innate_immunity0.72658462
135MP0000462_abnormal_digestive_system0.72508395
136MP0001544_abnormal_cardiovascular_syste0.72365856
137MP0005385_cardiovascular_system_phenoty0.72365856
138MP0000534_abnormal_ureter_morphology0.71417892
139MP0003948_abnormal_gas_homeostasis0.71291155
140MP0003252_abnormal_bile_duct0.71113713
141MP0002089_abnormal_postnatal_growth/wei0.70603699
142MP0001502_abnormal_circadian_rhythm0.70483812
143MP0002108_abnormal_muscle_morphology0.70282974
144MP0002269_muscular_atrophy0.70122341
145MP0000716_abnormal_immune_system0.69703830
146MP0000920_abnormal_myelination0.68502046
147MP0002132_abnormal_respiratory_system0.67902431
148MP0000955_abnormal_spinal_cord0.67558386
149MP0002060_abnormal_skin_morphology0.67208339
150MP0005410_abnormal_fertilization0.66479981
151MP0003075_altered_response_to0.64961117

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)3.95897613
2Hyperacusis (HP:0010780)3.95257027
3Cerebral aneurysm (HP:0004944)3.65084176
4Broad face (HP:0000283)3.14752224
5Shallow orbits (HP:0000586)3.05474008
6Macroorchidism (HP:0000053)2.96327123
7Abnormality of the fingertips (HP:0001211)2.92319401
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.89812045
9Short 4th metacarpal (HP:0010044)2.89812045
10Elfin facies (HP:0004428)2.77940375
11Broad metatarsal (HP:0001783)2.74875014
12Mitral valve prolapse (HP:0001634)2.57353020
13Aortic aneurysm (HP:0004942)2.56713907
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.54346656
15Verrucae (HP:0200043)2.53403512
16Papilloma (HP:0012740)2.53403512
17Protrusio acetabuli (HP:0003179)2.52892900
18Abnormality of the 4th metacarpal (HP:0010012)2.50895375
19Renovascular hypertension (HP:0100817)2.49965315
20Eczematoid dermatitis (HP:0000976)2.46258864
21Enlarged penis (HP:0000040)2.46122941
22Aneurysm (HP:0002617)2.43559551
23Renal duplication (HP:0000075)2.39413705
24B lymphocytopenia (HP:0010976)2.39234497
25Abnormality of B cell number (HP:0010975)2.39234497
26Lymphangioma (HP:0100764)2.38877545
27T lymphocytopenia (HP:0005403)2.38098630
28Vertebral arch anomaly (HP:0008438)2.36869700
29Increased density of long bones (HP:0006392)2.36116543
30Panhypogammaglobulinemia (HP:0003139)2.34619265
31Bladder diverticulum (HP:0000015)2.30412548
32Insomnia (HP:0100785)2.26600081
33Arterial tortuosity (HP:0005116)2.24911400
34Recurrent viral infections (HP:0004429)2.23932900
35Disproportionate tall stature (HP:0001519)2.20718698
36Dilatation of the ascending aorta (HP:0005111)2.19659144
37Vascular tortuosity (HP:0004948)2.16694395
38Abnormality of T cell number (HP:0011839)2.16693114
39Overriding aorta (HP:0002623)2.16553595
40Germ cell neoplasia (HP:0100728)2.14586582
41Bowel diverticulosis (HP:0005222)2.14513701
42Subacute progressive viral hepatitis (HP:0006572)2.13847097
43Turricephaly (HP:0000262)2.12762287
44Deviation of the hallux (HP:0010051)2.12421649
45Hallux valgus (HP:0001822)2.12273849
46Difficulty running (HP:0009046)2.11384635
47Papilledema (HP:0001085)2.11187905
48Cerebral inclusion bodies (HP:0100314)2.11146048
49Ulnar bowing (HP:0003031)2.09880075
50Thin bony cortex (HP:0002753)2.09436279
51Neurofibrillary tangles (HP:0002185)2.06188019
52Type 1 muscle fiber predominance (HP:0003803)2.06029950
53Neoplasm of the heart (HP:0100544)2.05953142
54Increased connective tissue (HP:0009025)2.04422134
55Long eyelashes (HP:0000527)2.02236559
56Cellulitis (HP:0100658)1.98490576
57Rectal prolapse (HP:0002035)1.98400311
58Flat cornea (HP:0007720)1.96560059
59Mildly elevated creatine phosphokinase (HP:0008180)1.95265121
60Distal lower limb amyotrophy (HP:0008944)1.95060851
61Hyporeflexia of lower limbs (HP:0002600)1.93728514
62Peritonitis (HP:0002586)1.93452745
63Dysmetric saccades (HP:0000641)1.93166869
64Asymmetry of the thorax (HP:0001555)1.93145170
65Bicuspid aortic valve (HP:0001647)1.92761202
66Narrow palate (HP:0000189)1.92734510
67Colitis (HP:0002583)1.92662469
68Abnormality of the left ventricular outflow tract (HP:0011103)1.91871538
69Subaortic stenosis (HP:0001682)1.91871538
70Aortic dissection (HP:0002647)1.91490654
71Centrally nucleated skeletal muscle fibers (HP:0003687)1.91173450
72Hematochezia (HP:0002573)1.91055765
73Thyroiditis (HP:0100646)1.90580935
74Increased nuchal translucency (HP:0010880)1.90059749
75Increased variability in muscle fiber diameter (HP:0003557)1.89779039
76Long toe (HP:0010511)1.88921897
77Exostoses (HP:0100777)1.88068576
78Ankle clonus (HP:0011448)1.87845671
79Striae distensae (HP:0001065)1.87094666
80Broad palm (HP:0001169)1.85506242
81Abnormality of the ischium (HP:0003174)1.84670819
82Gingivitis (HP:0000230)1.84434468
83Premature rupture of membranes (HP:0001788)1.84172369
84Trigonocephaly (HP:0000243)1.84019864
85Ankle contracture (HP:0006466)1.84000403
86Pointed chin (HP:0000307)1.82710688
87Overgrowth (HP:0001548)1.82475084
88Bowel incontinence (HP:0002607)1.82376291
89Distal lower limb muscle weakness (HP:0009053)1.81605990
90Increased IgE level (HP:0003212)1.81604266
91Spontaneous hematomas (HP:0007420)1.80931194
92Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79385829
93Atrophic scars (HP:0001075)1.78352447
94Supranuclear gaze palsy (HP:0000605)1.78207555
95Hypoplastic ischia (HP:0003175)1.77788955
96Hypoplasia of the thymus (HP:0000778)1.77273333
97Mitral regurgitation (HP:0001653)1.75743355
98Metaphyseal cupping (HP:0003021)1.75511556
99Abnormality of the distal phalanx of the thumb (HP:0009617)1.75283844
100Obsessive-compulsive behavior (HP:0000722)1.75049906
101Truncal obesity (HP:0001956)1.73046036
102Abnormality of skeletal muscle fiber size (HP:0012084)1.72119023
103Genu recurvatum (HP:0002816)1.72057261
104Onion bulb formation (HP:0003383)1.71159918
105Hypercortisolism (HP:0001578)1.70798565
106Gastrointestinal inflammation (HP:0004386)1.70541902
107Persistence of primary teeth (HP:0006335)1.69836048
108Scapular winging (HP:0003691)1.69618373
109Distal upper limb amyotrophy (HP:0007149)1.69345281
110Upper limb amyotrophy (HP:0009129)1.69345281
111Neonatal short-limb short stature (HP:0008921)1.69325743
112Frequent falls (HP:0002359)1.68059081
113Buphthalmos (HP:0000557)1.67823645
114Dislocated radial head (HP:0003083)1.66971816
115Back pain (HP:0003418)1.66430900
116Asymmetric septal hypertrophy (HP:0001670)1.65792952
117Agammaglobulinemia (HP:0004432)1.64095116
118Foot dorsiflexor weakness (HP:0009027)1.63734639
119Decreased motor nerve conduction velocity (HP:0003431)1.63570128
120Lower limb amyotrophy (HP:0007210)1.63235213
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.63101978
122Thick eyebrow (HP:0000574)1.63030037
123Heterotopia (HP:0002282)1.62775064
124Precocious puberty (HP:0000826)1.62308679
125Fragile skin (HP:0001030)1.62251958
126Patellar dislocation (HP:0002999)1.61800438
127Bell-shaped thorax (HP:0001591)1.61684277
128Thin ribs (HP:0000883)1.61323115
129Abnormality of the nasal mucosa (HP:0000433)1.60791050
130Bundle branch block (HP:0011710)1.60618066
131Atelectasis (HP:0100750)1.60206074
132Abnormal large intestine physiology (HP:0012700)1.59562988
133Inflammation of the large intestine (HP:0002037)1.59392355
134Cervical subluxation (HP:0003308)1.58905445
135Slender build (HP:0001533)1.58631093
136Muscle fiber splitting (HP:0003555)1.58460634
137Ulnar deviation of the wrist (HP:0003049)1.58032587
138Interstitial pulmonary disease (HP:0006530)1.57954066
139Abnormality of the radial head (HP:0003995)1.57188346
140Volvulus (HP:0002580)1.56781048
141Segmental peripheral demyelination/remyelination (HP:0003481)1.56254440
142Hyperparathyroidism (HP:0000843)1.56113301
143Hyperextensible skin (HP:0000974)1.55993273
144Abnormality of the gastric mucosa (HP:0004295)1.55951722
145Resting tremor (HP:0002322)1.55940145
146Exercise-induced myalgia (HP:0003738)1.55926093
147Eosinophilia (HP:0001880)1.55753742
148Severe combined immunodeficiency (HP:0004430)1.54836440
149EMG: neuropathic changes (HP:0003445)1.54747076
150Round ear (HP:0100830)1.54596875
151Abnormality of the aortic arch (HP:0012303)1.54138972
152Joint laxity (HP:0001388)1.52827528
153Flat acetabular roof (HP:0003180)1.52392017
154Peripheral hypomyelination (HP:0007182)1.52028579
155Abnormality of the foot musculature (HP:0001436)1.51980165
156Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.49454764
157Stereotypic behavior (HP:0000733)1.49095404
158Abnormality of the calcaneus (HP:0008364)1.48576405
159Hyperthyroidism (HP:0000836)1.47829259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.10494552
2MAP3K104.38872016
3PKN23.55402909
4PRPF4B3.50226729
5EEF2K3.26322890
6ERN12.70517947
7SIK12.19547193
8TTN2.18870568
9CDK122.10875486
10PTK62.10792017
11RIPK11.99316478
12PDGFRA1.93342908
13MAP4K11.92427912
14SIK21.81030042
15CAMK1G1.76293831
16ICK1.70947379
17DMPK1.68012214
18SMG11.64812010
19MAP3K71.59303001
20RIPK41.48990373
21PRKD31.42900942
22LRRK21.41423974
23CAMK1D1.39804519
24FGFR41.39774693
25EPHB11.38467012
26TAOK11.37244270
27MARK11.33986046
28PRKCH1.27575537
29PDGFRB1.26853585
30MAP3K131.23083553
31FGFR31.21886713
32GRK61.17092236
33CDK61.14498093
34MTOR1.13581931
35HIPK21.12915737
36LATS11.12595610
37BMX1.12285464
38ALK1.07661106
39ZAP701.07037766
40TESK11.06059778
41RET1.04201974
42JAK11.04112580
43MARK21.02766192
44FGFR21.02668183
45NTRK21.02141889
46DYRK1B1.00294791
47STK100.99983268
48INSRR0.99489804
49TNK20.95752652
50MAP3K60.95518613
51PRKD20.94404183
52TGFBR20.93311882
53UHMK10.92614500
54MAP3K20.91684370
55ITK0.89834645
56RPS6KC10.88791456
57RPS6KL10.88791456
58TYRO30.88541510
59PRKD10.86493237
60SGK20.84972108
61EPHA30.82523022
62SGK4940.80821306
63SGK2230.80821306
64NTRK10.80388852
65SGK30.80044813
66LATS20.79906726
67CAMKK10.77660162
68TYK20.77359908
69WNK10.76490705
70IRAK40.75729727
71NEK20.75655886
72TAOK30.75208466
73HCK0.73265075
74CSK0.72295608
75MAP3K30.72247637
76CDC42BPA0.71238203
77SIK30.69708041
78IRAK20.69413307
79DDR20.68934762
80RPS6KA60.68170514
81MAPK150.67918800
82BLK0.67901515
83JAK20.65034019
84MOS0.64701063
85PAK20.64046925
86CDK40.63867608
87PTK20.63824271
88MAP2K20.63696222
89NTRK30.63243829
90YES10.60912008
91LMTK20.60472940
92CDK90.60437378
93IRAK30.60054210
94JAK30.57831950
95ILK0.57519945
96KSR10.56495050
97BTK0.56474331
98STK30.55288891
99MAP3K140.54759213
100MAP3K10.54420956
101MAPK100.54338662
102PAK40.54028034
103SYK0.53854404
104PAK60.53267241
105BRD40.52198136
106MAP3K90.51220066
107ROCK20.50102915
108MAP2K40.49417034
109TAOK20.48379880
110CSF1R0.48367969
111NLK0.48214496
112FGFR10.48206469
113STK110.48048385
114CAMK40.44863764
115STK380.44794480
116PDK10.44403970
117MAPK70.43886644
118EPHB20.43736855
119RPS6KA20.43167895
120CHUK0.42734294
121PRKAA10.41726208
122CLK10.41440921
123KSR20.41047548
124MAP2K30.40870704
125PTK2B0.38963044
126MAPK120.38625888
127FYN0.38250219
128SCYL20.37274610
129MAPK110.35979457
130MARK30.35823407
131ERBB20.34926141
132RPS6KA40.34520036
133PDPK10.34109382
134FES0.33843783
135PAK30.33483755
136TBK10.33309583
137INSR0.33110755
138MAPK80.32516586

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052202.02462750
2Primary immunodeficiency_Homo sapiens_hsa053401.80259141
3B cell receptor signaling pathway_Homo sapiens_hsa046621.70605516
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69522282
5Lysine degradation_Homo sapiens_hsa003101.64412334
6Insulin resistance_Homo sapiens_hsa049311.53232945
7Type II diabetes mellitus_Homo sapiens_hsa049301.52347318
8mTOR signaling pathway_Homo sapiens_hsa041501.47203834
9Endometrial cancer_Homo sapiens_hsa052131.44533415
10T cell receptor signaling pathway_Homo sapiens_hsa046601.43546056
11Acute myeloid leukemia_Homo sapiens_hsa052211.41891005
12Non-small cell lung cancer_Homo sapiens_hsa052231.41377570
13Glioma_Homo sapiens_hsa052141.36497464
14Dorso-ventral axis formation_Homo sapiens_hsa043201.34998542
15Proteoglycans in cancer_Homo sapiens_hsa052051.30954704
16Focal adhesion_Homo sapiens_hsa045101.30780874
17Thyroid hormone signaling pathway_Homo sapiens_hsa049191.28545502
18Neurotrophin signaling pathway_Homo sapiens_hsa047221.28257633
19Osteoclast differentiation_Homo sapiens_hsa043801.27880966
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27751958
21Adherens junction_Homo sapiens_hsa045201.27662520
22Pancreatic cancer_Homo sapiens_hsa052121.26195910
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25450541
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24970211
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22074679
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21880791
27VEGF signaling pathway_Homo sapiens_hsa043701.19404854
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19147581
29Estrogen signaling pathway_Homo sapiens_hsa049151.18540073
30Dilated cardiomyopathy_Homo sapiens_hsa054141.16827606
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16501129
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15263147
33Colorectal cancer_Homo sapiens_hsa052101.14861744
34Nitrogen metabolism_Homo sapiens_hsa009101.14786905
35Viral myocarditis_Homo sapiens_hsa054161.14304593
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12603951
37Small cell lung cancer_Homo sapiens_hsa052221.11983995
38Platelet activation_Homo sapiens_hsa046111.11797635
39Insulin signaling pathway_Homo sapiens_hsa049101.09182016
40Notch signaling pathway_Homo sapiens_hsa043301.09160043
41Renal cell carcinoma_Homo sapiens_hsa052111.08990791
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.08171940
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08045918
44Inositol phosphate metabolism_Homo sapiens_hsa005621.07797226
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06250765
46Prostate cancer_Homo sapiens_hsa052151.04688077
47Toxoplasmosis_Homo sapiens_hsa051451.04653155
48MicroRNAs in cancer_Homo sapiens_hsa052061.03828681
49Adipocytokine signaling pathway_Homo sapiens_hsa049201.03666491
50Prolactin signaling pathway_Homo sapiens_hsa049171.01261714
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99641420
52Prion diseases_Homo sapiens_hsa050200.99388499
53AMPK signaling pathway_Homo sapiens_hsa041520.98331617
54FoxO signaling pathway_Homo sapiens_hsa040680.97014183
55Glucagon signaling pathway_Homo sapiens_hsa049220.96580248
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95130501
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93895352
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.91845411
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90944907
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90271228
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87934328
62Amoebiasis_Homo sapiens_hsa051460.87694560
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.87547463
64Other glycan degradation_Homo sapiens_hsa005110.86850645
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.85484810
66HTLV-I infection_Homo sapiens_hsa051660.85423481
67Chemokine signaling pathway_Homo sapiens_hsa040620.84874682
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83017928
69Bladder cancer_Homo sapiens_hsa052190.82807174
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81616742
71ErbB signaling pathway_Homo sapiens_hsa040120.81418792
72Basal cell carcinoma_Homo sapiens_hsa052170.80442114
73Gastric acid secretion_Homo sapiens_hsa049710.80205189
74Hepatitis B_Homo sapiens_hsa051610.80032630
75Axon guidance_Homo sapiens_hsa043600.77345670
76Hepatitis C_Homo sapiens_hsa051600.76708032
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76408901
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76149515
79ECM-receptor interaction_Homo sapiens_hsa045120.75854365
80Oxytocin signaling pathway_Homo sapiens_hsa049210.74992059
81Renin secretion_Homo sapiens_hsa049240.74964435
82MAPK signaling pathway_Homo sapiens_hsa040100.74797082
83Insulin secretion_Homo sapiens_hsa049110.72910544
84Rap1 signaling pathway_Homo sapiens_hsa040150.72544173
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71909084
86Choline metabolism in cancer_Homo sapiens_hsa052310.71545570
87Long-term potentiation_Homo sapiens_hsa047200.71231164
88Endocytosis_Homo sapiens_hsa041440.71181882
89Circadian entrainment_Homo sapiens_hsa047130.71056936
90Thyroid cancer_Homo sapiens_hsa052160.69371309
91Tuberculosis_Homo sapiens_hsa051520.69258189
92Cocaine addiction_Homo sapiens_hsa050300.69190656
93GnRH signaling pathway_Homo sapiens_hsa049120.66495772
94Leishmaniasis_Homo sapiens_hsa051400.66279062
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65726380
96Influenza A_Homo sapiens_hsa051640.65671190
97Long-term depression_Homo sapiens_hsa047300.65272520
98Malaria_Homo sapiens_hsa051440.65266025
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64845261
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.64753888
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.64416860
102Pathways in cancer_Homo sapiens_hsa052000.64341258
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64255558
104Melanogenesis_Homo sapiens_hsa049160.63858589
105Ras signaling pathway_Homo sapiens_hsa040140.63857936
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63486894
107Antigen processing and presentation_Homo sapiens_hsa046120.63399196
108Measles_Homo sapiens_hsa051620.62353148
109Wnt signaling pathway_Homo sapiens_hsa043100.61124579
110HIF-1 signaling pathway_Homo sapiens_hsa040660.60925905
111TNF signaling pathway_Homo sapiens_hsa046680.60821306
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59049515
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58805620
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.58603449
115Gap junction_Homo sapiens_hsa045400.58378189
116cAMP signaling pathway_Homo sapiens_hsa040240.58173534
117Protein digestion and absorption_Homo sapiens_hsa049740.57730441
118Cholinergic synapse_Homo sapiens_hsa047250.56244628

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