PHF14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.25337595
2behavioral response to nicotine (GO:0035095)3.95917423
3pyrimidine nucleobase catabolic process (GO:0006208)3.83155668
4histone H3-K4 trimethylation (GO:0080182)3.73691602
5interkinetic nuclear migration (GO:0022027)3.64720681
6cerebral cortex radially oriented cell migration (GO:0021799)3.58724952
7negative regulation of DNA-dependent DNA replication (GO:2000104)3.49040650
8presynaptic membrane assembly (GO:0097105)3.48692186
9mRNA splice site selection (GO:0006376)3.43288024
10central nervous system projection neuron axonogenesis (GO:0021952)3.33472893
11regulation of DNA endoreduplication (GO:0032875)3.29192905
12neuron cell-cell adhesion (GO:0007158)3.25730718
13limb bud formation (GO:0060174)3.16785893
14neurofilament cytoskeleton organization (GO:0060052)2.98570515
15kinetochore organization (GO:0051383)2.97982564
16transmission of nerve impulse (GO:0019226)2.97921849
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.94974683
18kidney morphogenesis (GO:0060993)2.93171946
19presynaptic membrane organization (GO:0097090)2.92074107
20nucleobase catabolic process (GO:0046113)2.90839730
21cell proliferation in forebrain (GO:0021846)2.90132533
22dendritic spine morphogenesis (GO:0060997)2.87770523
23lymphoid progenitor cell differentiation (GO:0002320)2.86847145
24resolution of meiotic recombination intermediates (GO:0000712)2.86337396
25body morphogenesis (GO:0010171)2.83418968
26negative regulation of translation, ncRNA-mediated (GO:0040033)2.81476535
27regulation of translation, ncRNA-mediated (GO:0045974)2.81476535
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81476535
29postsynaptic membrane organization (GO:0001941)2.78347870
30DNA strand renaturation (GO:0000733)2.75437696
31retinal ganglion cell axon guidance (GO:0031290)2.74368402
32embryonic body morphogenesis (GO:0010172)2.74295927
33central nervous system neuron axonogenesis (GO:0021955)2.73836346
34peptidyl-lysine trimethylation (GO:0018023)2.71822629
35regulation of DNA methylation (GO:0044030)2.70164575
36regulation of telomere maintenance (GO:0032204)2.65971896
37histone H3-K4 methylation (GO:0051568)2.65918622
38hindbrain development (GO:0030902)2.64360221
39genetic imprinting (GO:0071514)2.60604627
40cell differentiation involved in kidney development (GO:0061005)2.60439667
41protein localization to synapse (GO:0035418)2.58670807
42synaptic vesicle maturation (GO:0016188)2.58572742
43chromatin remodeling at centromere (GO:0031055)2.57082577
44axonal fasciculation (GO:0007413)2.56344843
45regulation of non-canonical Wnt signaling pathway (GO:2000050)2.56011757
46retina layer formation (GO:0010842)2.55992302
47kinetochore assembly (GO:0051382)2.55232099
48neuron recognition (GO:0008038)2.53236374
49regulation of pigment cell differentiation (GO:0050932)2.52873858
50epithelial cell differentiation involved in kidney development (GO:0035850)2.48087146
51regulation of gene silencing by RNA (GO:0060966)2.48021398
52regulation of posttranscriptional gene silencing (GO:0060147)2.48021398
53regulation of gene silencing by miRNA (GO:0060964)2.48021398
54histone H3-K9 methylation (GO:0051567)2.47654940
55positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.46977364
56generation of neurons (GO:0048699)2.46448647
57DNA topological change (GO:0006265)2.46442484
58somite development (GO:0061053)2.44869306
59pre-miRNA processing (GO:0031054)2.44782458
60dendrite morphogenesis (GO:0048813)2.44438541
61regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.43984668
62establishment of nucleus localization (GO:0040023)2.43451503
63regulation of histone H3-K9 methylation (GO:0051570)2.43122289
64regulation of centriole replication (GO:0046599)2.42829103
65nucleus localization (GO:0051647)2.42673413
66microtubule anchoring (GO:0034453)2.41096097
67meiotic chromosome segregation (GO:0045132)2.40844492
68substrate-independent telencephalic tangential migration (GO:0021826)2.40544592
69substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.40544592
70intraciliary transport (GO:0042073)2.40513135
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.40351452
72cytoplasmic mRNA processing body assembly (GO:0033962)2.39619097
73detection of light stimulus involved in sensory perception (GO:0050962)2.39511096
74detection of light stimulus involved in visual perception (GO:0050908)2.39511096
75dentate gyrus development (GO:0021542)2.39215408
76positive regulation of dendritic spine morphogenesis (GO:0061003)2.38146437
77cardiac ventricle formation (GO:0003211)2.37380603
78startle response (GO:0001964)2.37277813
79centriole replication (GO:0007099)2.36413960
80sister chromatid cohesion (GO:0007062)2.36088903
81cranial nerve morphogenesis (GO:0021602)2.36003635
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.35562520
83neural tube formation (GO:0001841)2.35537226
84regulation of meiosis I (GO:0060631)2.34594093
85mitochondrion transport along microtubule (GO:0047497)2.34467335
86establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.34467335
87regulation of mRNA splicing, via spliceosome (GO:0048024)2.33960920
88definitive hemopoiesis (GO:0060216)2.32796642
89establishment of mitochondrion localization (GO:0051654)2.32359840
90gamma-aminobutyric acid transport (GO:0015812)2.30554338
91mesenchymal cell differentiation involved in kidney development (GO:0072161)2.29664933
92mesenchymal cell differentiation involved in renal system development (GO:2001012)2.29664933
93axon extension (GO:0048675)2.29551103
94lateral sprouting from an epithelium (GO:0060601)2.28048210
95cardiac chamber formation (GO:0003207)2.27885105
96regulation of short-term neuronal synaptic plasticity (GO:0048172)2.27572979
97cranial nerve structural organization (GO:0021604)2.27547350
98CENP-A containing nucleosome assembly (GO:0034080)2.27539093
99protein neddylation (GO:0045116)2.27300105
100mechanosensory behavior (GO:0007638)2.27161344
101facial nerve structural organization (GO:0021612)2.27152721
102head development (GO:0060322)2.25936110
103piRNA metabolic process (GO:0034587)2.25727688
104auditory behavior (GO:0031223)2.25554995
105cerebral cortex cell migration (GO:0021795)2.25451022
106adult walking behavior (GO:0007628)2.24738204
107regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.24709788
108histone lysine methylation (GO:0034968)2.23936529
109ionotropic glutamate receptor signaling pathway (GO:0035235)2.23630674
110epithelial cilium movement (GO:0003351)2.23577191
111neuron projection extension involved in neuron projection guidance (GO:1902284)2.23204192
112axon extension involved in axon guidance (GO:0048846)2.23204192
113regulation of gene expression by genetic imprinting (GO:0006349)2.22627748
114positive regulation of gastrulation (GO:2000543)2.22529167
115regulation of histone H3-K27 methylation (GO:0061085)2.22117406
116dendrite development (GO:0016358)2.21516510
117microtubule depolymerization (GO:0007019)2.20978177
118replication fork processing (GO:0031297)2.20288102
119translational termination (GO:0006415)2.20138770
120sympathetic nervous system development (GO:0048485)2.20034791
121ribosomal small subunit biogenesis (GO:0042274)2.19973940
122DNA ligation (GO:0006266)2.19750944
123regulation of centrosome cycle (GO:0046605)2.19324980
124positive regulation of DNA-dependent DNA replication (GO:2000105)2.18667285
125olfactory bulb development (GO:0021772)2.18410885
126spinal cord development (GO:0021510)2.17902209
127negative regulation of axon extension involved in axon guidance (GO:0048843)2.17864623
128negative regulation of neurotransmitter secretion (GO:0046929)2.17455422
129mesenchymal cell differentiation (GO:0048762)2.16808211
130protein polyglutamylation (GO:0018095)2.15938060
131regulation of synapse assembly (GO:0051963)2.15852609
132atrial septum morphogenesis (GO:0060413)2.15707269
133DNA methylation involved in gamete generation (GO:0043046)2.15660472
134synapse assembly (GO:0007416)2.15112084
135spinal cord motor neuron differentiation (GO:0021522)2.14960748
136artery development (GO:0060840)2.14927067
137viral transcription (GO:0019083)2.14614836
138centriole assembly (GO:0098534)2.14577316
139anatomical structure arrangement (GO:0048532)2.14377414
140negative regulation of axon guidance (GO:1902668)2.13387569
141regulation of sarcomere organization (GO:0060297)2.13026277
142regulation of nuclear cell cycle DNA replication (GO:0033262)2.12355709
143glutamate receptor signaling pathway (GO:0007215)2.12195796
144regulation of centrosome duplication (GO:0010824)2.11509370
145intra-S DNA damage checkpoint (GO:0031573)2.10527344
146neuron migration (GO:0001764)2.10323064
147ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.10280241
148maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.10267214
149negative regulation of DNA recombination (GO:0045910)2.09771984
150V(D)J recombination (GO:0033151)2.09572818
151epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.09276371
152neurotransmitter-gated ion channel clustering (GO:0072578)2.08963116
153histone exchange (GO:0043486)2.08957417
154thalamus development (GO:0021794)2.08750797
155regulation of respiratory system process (GO:0044065)2.08085358
156ganglion development (GO:0061548)2.07931583
157synapsis (GO:0007129)2.07564940
158regulation of mRNA processing (GO:0050684)2.05403468
159positive regulation of histone H3-K4 methylation (GO:0051571)2.04990628
160forebrain neuron differentiation (GO:0021879)2.04971761
161developmental pigmentation (GO:0048066)2.03344508
162regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.03020229
163cell differentiation in spinal cord (GO:0021515)2.02122189
164regulation of glutamate receptor signaling pathway (GO:1900449)2.01321139
165neuronal stem cell maintenance (GO:0097150)2.01255320
166cell migration in hindbrain (GO:0021535)2.01148362
167vocalization behavior (GO:0071625)2.01086360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.67804706
2EZH2_22144423_ChIP-Seq_EOC_Human3.41595436
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.36446066
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.88998073
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.71227313
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64087476
7E2F7_22180533_ChIP-Seq_HELA_Human2.55562894
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.54541520
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52480028
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30928881
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27099934
12* FUS_26573619_Chip-Seq_HEK293_Human2.21551531
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21205359
14* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.20194481
15TAF15_26573619_Chip-Seq_HEK293_Human2.07413597
16IGF1R_20145208_ChIP-Seq_DFB_Human2.06649251
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00849380
18EWS_26573619_Chip-Seq_HEK293_Human1.99869899
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.97171354
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91622468
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.87390222
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.84100013
23P300_19829295_ChIP-Seq_ESCs_Human1.78350937
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76734933
25REST_21632747_ChIP-Seq_MESCs_Mouse1.74403020
26GATA1_26923725_Chip-Seq_HPCs_Mouse1.73645090
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.73524445
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.70045458
29VDR_22108803_ChIP-Seq_LS180_Human1.67194542
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.66715208
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66715208
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.65275963
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65072594
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65063905
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64344937
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63931481
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61071937
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60161500
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.59281361
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57509825
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56999480
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.56233055
43AR_21572438_ChIP-Seq_LNCaP_Human1.56146188
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54588136
45SMAD4_21799915_ChIP-Seq_A2780_Human1.53716256
46RNF2_27304074_Chip-Seq_NSC_Mouse1.53374663
47* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52964047
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52554873
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.48903516
50* STAT3_23295773_ChIP-Seq_U87_Human1.48468251
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48217549
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.48209336
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47709359
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46617309
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46577782
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.44615349
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44296487
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44142547
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43784208
60* TP53_16413492_ChIP-PET_HCT116_Human1.43132877
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.43120757
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41891877
63IRF1_19129219_ChIP-ChIP_H3396_Human1.41452682
64SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37031257
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36420165
66* TCF4_23295773_ChIP-Seq_U87_Human1.36158831
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35298822
68P53_22387025_ChIP-Seq_ESCs_Mouse1.34571752
69ER_23166858_ChIP-Seq_MCF-7_Human1.33183312
70* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32667003
71SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32516769
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32270750
73EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31997062
74RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31997062
75* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31927906
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.31770160
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31705927
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.31325352
79* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31279004
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30793554
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28488064
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.24948367
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24574850
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24044813
85* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23495841
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.23301462
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23163922
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22340886
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21151639
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20664279
91ZNF274_21170338_ChIP-Seq_K562_Hela1.20468394
92P300_18555785_Chip-Seq_ESCs_Mouse1.20385857
93RUNX2_22187159_ChIP-Seq_PCA_Human1.20016769
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.19886330
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19682408
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19204639
97FOXM1_23109430_ChIP-Seq_U2OS_Human1.18893655
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18339289
99AR_25329375_ChIP-Seq_VCAP_Human1.17619643
100* ARNT_22903824_ChIP-Seq_MCF-7_Human1.17003734
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15747488
102NMYC_18555785_Chip-Seq_ESCs_Mouse1.15407403
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15133559
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.14053060
105TCF4_18268006_ChIP-ChIP_LS174T_Human1.13796370
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13469211
107E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13034798
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11964763
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10605158
110FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09246330
111OCT4_18555785_Chip-Seq_ESCs_Mouse1.09173726
112DROSHA_22980978_ChIP-Seq_HELA_Human1.08789633
113SOX9_26525672_Chip-Seq_HEART_Mouse1.08741399
114WT1_19549856_ChIP-ChIP_CCG9911_Human1.08681611
115EZH2_27294783_Chip-Seq_ESCs_Mouse1.08021514
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08020155
117* JUN_21703547_ChIP-Seq_K562_Human1.05605409
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04496290
119CBP_20019798_ChIP-Seq_JUKART_Human1.04496290
120MYC_18940864_ChIP-ChIP_HL60_Human1.02906287
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01873920
122EST1_17652178_ChIP-ChIP_JURKAT_Human0.98171351
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.96866800
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96646295
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96298880
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95957903
127E2F1_21310950_ChIP-Seq_MCF-7_Human0.95942020
128KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93549932
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93273577
130TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90207726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.15113138
2MP0003787_abnormal_imprinting3.71988968
3MP0001188_hyperpigmentation2.80509279
4MP0003121_genomic_imprinting2.67901930
5MP0005409_darkened_coat_color2.66602937
6MP0006292_abnormal_olfactory_placode2.36673582
7MP0000778_abnormal_nervous_system2.30708930
8MP0005171_absent_coat_pigmentation2.09703882
9MP0005423_abnormal_somatic_nervous2.08276393
10MP0002102_abnormal_ear_morphology2.01962110
11MP0003880_abnormal_central_pattern1.91554352
12MP0005174_abnormal_tail_pigmentation1.88243889
13MP0003122_maternal_imprinting1.87753038
14MP0000015_abnormal_ear_pigmentation1.86712648
15MP0008877_abnormal_DNA_methylation1.81472974
16MP0001486_abnormal_startle_reflex1.81331207
17MP0003136_yellow_coat_color1.79868167
18MP0000383_abnormal_hair_follicle1.78475791
19MP0002938_white_spotting1.77982336
20MP0001293_anophthalmia1.77296467
21MP0008057_abnormal_DNA_replication1.76663868
22MP0003890_abnormal_embryonic-extraembry1.53793451
23MP0004859_abnormal_synaptic_plasticity1.53147545
24MP0010094_abnormal_chromosome_stability1.51683255
25MP0002822_catalepsy1.49172015
26MP0002396_abnormal_hematopoietic_system1.48266681
27MP0002009_preneoplasia1.48248335
28MP0002095_abnormal_skin_pigmentation1.44089561
29MP0002638_abnormal_pupillary_reflex1.42927898
30MP0004270_analgesia1.42836501
31MP0003937_abnormal_limbs/digits/tail_de1.42360806
32MP0003693_abnormal_embryo_hatching1.41723687
33MP0003635_abnormal_synaptic_transmissio1.39685441
34MP0002735_abnormal_chemical_nociception1.38322443
35MP0004142_abnormal_muscle_tone1.37284190
36MP0008058_abnormal_DNA_repair1.37274842
37MP0004885_abnormal_endolymph1.34548158
38MP0000631_abnormal_neuroendocrine_gland1.34397739
39MP0003385_abnormal_body_wall1.33720707
40MP0003938_abnormal_ear_development1.32302890
41MP0002160_abnormal_reproductive_system1.30617939
42MP0005394_taste/olfaction_phenotype1.29002839
43MP0005499_abnormal_olfactory_system1.29002839
44MP0008789_abnormal_olfactory_epithelium1.27304812
45MP0010678_abnormal_skin_adnexa1.27232511
46MP0000049_abnormal_middle_ear1.26983926
47MP0002557_abnormal_social/conspecific_i1.25924085
48MP0005551_abnormal_eye_electrophysiolog1.24880582
49MP0001529_abnormal_vocalization1.24031863
50MP0000566_synostosis1.21530548
51MP0002752_abnormal_somatic_nervous1.20990326
52MP0002234_abnormal_pharynx_morphology1.20193650
53MP0005645_abnormal_hypothalamus_physiol1.18696927
54MP0002063_abnormal_learning/memory/cond1.17343146
55MP0000372_irregular_coat_pigmentation1.16972075
56MP0002184_abnormal_innervation1.16932865
57MP0003861_abnormal_nervous_system1.16708953
58MP0003315_abnormal_perineum_morphology1.16649697
59MP0002177_abnormal_outer_ear1.14419664
60MP0002210_abnormal_sex_determination1.14362172
61MP0000537_abnormal_urethra_morphology1.14294668
62MP0009745_abnormal_behavioral_response1.14154456
63MP0003755_abnormal_palate_morphology1.13641741
64MP0003119_abnormal_digestive_system1.13241599
65MP0002163_abnormal_gland_morphology1.13018849
66MP0004133_heterotaxia1.12284876
67MP0003718_maternal_effect1.12281269
68MP0003123_paternal_imprinting1.12193469
69MP0010030_abnormal_orbit_morphology1.11441417
70MP0002572_abnormal_emotion/affect_behav1.10801844
71MP0009250_abnormal_appendicular_skeleto1.08190453
72MP0003942_abnormal_urinary_system1.06206477
73MP0004742_abnormal_vestibular_system1.03181558
74MP0002734_abnormal_mechanical_nocicepti1.03181259
75MP0003935_abnormal_craniofacial_develop1.02869398
76MP0001440_abnormal_grooming_behavior1.01300718
77MP0002751_abnormal_autonomic_nervous1.00829793
78MP0004808_abnormal_hematopoietic_stem1.00618322
79MP0001485_abnormal_pinna_reflex1.00385477
80MP0001879_abnormal_lymphatic_vessel0.99394309
81MP0002116_abnormal_craniofacial_bone0.99088740
82MP0004381_abnormal_hair_follicle0.98622696
83MP0005075_abnormal_melanosome_morpholog0.98449610
84MP0005195_abnormal_posterior_eye0.98219335
85MP0005367_renal/urinary_system_phenotyp0.98041823
86MP0000516_abnormal_urinary_system0.98041823
87MP0005646_abnormal_pituitary_gland0.96373172
88MP0001984_abnormal_olfaction0.95407987
89MP0003111_abnormal_nucleus_morphology0.94907924
90MP0002697_abnormal_eye_size0.94874129
91MP0000955_abnormal_spinal_cord0.92913699
92MP0002084_abnormal_developmental_patter0.92753334
93MP0009703_decreased_birth_body0.91414254
94MP0005187_abnormal_penis_morphology0.91218725
95MP0005248_abnormal_Harderian_gland0.91020257
96MP0002152_abnormal_brain_morphology0.90133210
97MP0002067_abnormal_sensory_capabilities0.89905866
98MP0001963_abnormal_hearing_physiology0.89351150
99MP0000026_abnormal_inner_ear0.89052162
100MP0000427_abnormal_hair_cycle0.88298649
101MP0001145_abnormal_male_reproductive0.88177889
102MP0004145_abnormal_muscle_electrophysio0.87656100
103MP0002081_perinatal_lethality0.87472404
104MP0001968_abnormal_touch/_nociception0.86735586
105MP0000653_abnormal_sex_gland0.85810288
106MP0003698_abnormal_male_reproductive0.85609798
107MP0002882_abnormal_neuron_morphology0.85607925
108MP0009046_muscle_twitch0.85598558
109MP0001970_abnormal_pain_threshold0.84973121
110MP0002233_abnormal_nose_morphology0.84743643
111MP0001929_abnormal_gametogenesis0.83595895
112MP0006072_abnormal_retinal_apoptosis0.83243773
113MP0005391_vision/eye_phenotype0.83032741
114MP0002733_abnormal_thermal_nociception0.82696718
115MP0000462_abnormal_digestive_system0.82610396
116MP0002075_abnormal_coat/hair_pigmentati0.82359662
117MP0008932_abnormal_embryonic_tissue0.82144528
118MP0009379_abnormal_foot_pigmentation0.81776848
119MP0005377_hearing/vestibular/ear_phenot0.81743296
120MP0003878_abnormal_ear_physiology0.81743296
121MP0000432_abnormal_head_morphology0.81111768
122MP0001186_pigmentation_phenotype0.80908502
123MP0002249_abnormal_larynx_morphology0.80465010
124MP0004811_abnormal_neuron_physiology0.78041941
125MP0003567_abnormal_fetal_cardiomyocyte0.77186860
126MP0002109_abnormal_limb_morphology0.76694138
127MP0002064_seizures0.75514050
128MP0006276_abnormal_autonomic_nervous0.75380625
129MP0005386_behavior/neurological_phenoty0.74497310
130MP0004924_abnormal_behavior0.74497310
131MP0002272_abnormal_nervous_system0.73468050
132MP0001286_abnormal_eye_development0.73351569
133MP0002736_abnormal_nociception_after0.72925128
134MP0002114_abnormal_axial_skeleton0.72294949
135MP0009697_abnormal_copulation0.71516308
136MP0003077_abnormal_cell_cycle0.70674760
137MP0003943_abnormal_hepatobiliary_system0.70666409
138MP0005379_endocrine/exocrine_gland_phen0.69956586
139MP0001177_atelectasis0.69599412

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.76227373
2Chromsome breakage (HP:0040012)3.72716390
3Volvulus (HP:0002580)3.67933694
4Abnormality of the labia minora (HP:0012880)3.38158723
5Myokymia (HP:0002411)3.22648296
6Protruding tongue (HP:0010808)2.87936099
7Limb dystonia (HP:0002451)2.79384950
8Abnormality of midbrain morphology (HP:0002418)2.66097835
9Molar tooth sign on MRI (HP:0002419)2.66097835
10Abnormality of the fingertips (HP:0001211)2.59721881
11Pancreatic fibrosis (HP:0100732)2.57205194
12Midline defect of the nose (HP:0004122)2.55948130
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.46685971
14Short 4th metacarpal (HP:0010044)2.46685971
15Febrile seizures (HP:0002373)2.42636834
16Nephronophthisis (HP:0000090)2.41546038
17Colon cancer (HP:0003003)2.40569493
18Absent frontal sinuses (HP:0002688)2.40483135
19Abnormality of the parietal bone (HP:0002696)2.30144775
20Aqueductal stenosis (HP:0002410)2.29488869
21Broad-based gait (HP:0002136)2.28628924
22Ectopic kidney (HP:0000086)2.27726310
23Tented upper lip vermilion (HP:0010804)2.26040927
24Hyperventilation (HP:0002883)2.23444663
25Papillary thyroid carcinoma (HP:0002895)2.23356026
26Abnormality of the corticospinal tract (HP:0002492)2.22483860
27Supernumerary ribs (HP:0005815)2.18377433
28Drooling (HP:0002307)2.17254993
29Excessive salivation (HP:0003781)2.17254993
30Papilledema (HP:0001085)2.17127431
31Generalized hypopigmentation of hair (HP:0011358)2.16367249
32Inappropriate behavior (HP:0000719)2.15124967
33Septo-optic dysplasia (HP:0100842)2.14571192
34Nephroblastoma (Wilms tumor) (HP:0002667)2.12557428
35Abnormality of the renal medulla (HP:0100957)2.10877751
36Exotropia (HP:0000577)2.08259948
37Widely spaced teeth (HP:0000687)2.04850994
38Congenital stationary night blindness (HP:0007642)2.04558214
39Acute lymphatic leukemia (HP:0006721)2.03623608
40Abnormality of the nasal septum (HP:0000419)2.03582674
41High anterior hairline (HP:0009890)2.03047639
42Reticulocytopenia (HP:0001896)2.02480793
43Pachygyria (HP:0001302)2.00857142
44Embryonal renal neoplasm (HP:0011794)2.00805194
45Abnormality of the incisor (HP:0000676)1.99955002
46Abnormality of cells of the erythroid lineage (HP:0012130)1.99943367
47True hermaphroditism (HP:0010459)1.99845995
48Abnormality of chromosome stability (HP:0003220)1.98342137
49Fair hair (HP:0002286)1.98032967
50Abnormality of chromosome segregation (HP:0002916)1.97611852
51Chin dimple (HP:0010751)1.97544911
52Diastasis recti (HP:0001540)1.96628520
53Pancreatic cysts (HP:0001737)1.96490396
54Stomach cancer (HP:0012126)1.96319086
55Duplicated collecting system (HP:0000081)1.95657937
56Gastroesophageal reflux (HP:0002020)1.94811271
57Abnormality of the intervertebral disk (HP:0005108)1.93831663
58Gait imbalance (HP:0002141)1.93368575
59Supernumerary bones of the axial skeleton (HP:0009144)1.93299277
60Increased number of teeth (HP:0011069)1.92970143
61Progressive cerebellar ataxia (HP:0002073)1.92849449
62Cupped ear (HP:0000378)1.91701028
63Tubulointerstitial nephritis (HP:0001970)1.91487205
64Rib fusion (HP:0000902)1.90802544
65Aplasia/Hypoplasia of the sternum (HP:0006714)1.90659817
66Chronic hepatic failure (HP:0100626)1.90581752
67Birth length less than 3rd percentile (HP:0003561)1.90020745
68Aplasia/Hypoplasia of the tibia (HP:0005772)1.89927630
69Abnormality of the renal collecting system (HP:0004742)1.89340760
70Anophthalmia (HP:0000528)1.89044109
71Metaphyseal dysplasia (HP:0100255)1.89022333
72Small hand (HP:0200055)1.88868667
73Lissencephaly (HP:0001339)1.88510703
74Syringomyelia (HP:0003396)1.87854969
75Spinal cord lesions (HP:0100561)1.87854969
76Long eyelashes (HP:0000527)1.87426541
77Patellar aplasia (HP:0006443)1.86974631
78Aplasia/Hypoplasia of the uvula (HP:0010293)1.85661722
79White forelock (HP:0002211)1.84489623
80Prostate neoplasm (HP:0100787)1.83871534
81Supernumerary spleens (HP:0009799)1.83352930
82Medial flaring of the eyebrow (HP:0010747)1.82920988
83Abnormal number of incisors (HP:0011064)1.82638859
84Oligodactyly (HP:0012165)1.82029063
85Blue irides (HP:0000635)1.81286282
86Narrow palate (HP:0000189)1.81198060
87Abnormality of incisor morphology (HP:0011063)1.81048852
88Medulloblastoma (HP:0002885)1.81001983
89Absent speech (HP:0001344)1.80647426
90Thyroiditis (HP:0100646)1.80446675
91Optic nerve hypoplasia (HP:0000609)1.79797563
92Asymmetry of the thorax (HP:0001555)1.79261545
93Truncal obesity (HP:0001956)1.78828504
94Short middle phalanx of the 5th finger (HP:0004220)1.78705243
95Intestinal atresia (HP:0011100)1.78373329
96Renovascular hypertension (HP:0100817)1.78193505
97Osteomalacia (HP:0002749)1.77833271
98Long nose (HP:0003189)1.76934814
99Impulsivity (HP:0100710)1.76628523
100Cutaneous finger syndactyly (HP:0010554)1.76052187
101Aplasia/Hypoplasia of the patella (HP:0006498)1.75866651
102Bifid tongue (HP:0010297)1.75761498
103Narrow forehead (HP:0000341)1.75348740
104Abnormality of the columella (HP:0009929)1.75223819
105Genetic anticipation (HP:0003743)1.74866242
106Oligodactyly (hands) (HP:0001180)1.74448882
107Abnormality of DNA repair (HP:0003254)1.74058660
108Sclerocornea (HP:0000647)1.73941001
109Obsessive-compulsive behavior (HP:0000722)1.73721761
110Hypoplasia of the maxilla (HP:0000327)1.73587495
111Focal seizures (HP:0007359)1.73149554
112Labial hypoplasia (HP:0000066)1.72943335
113Patchy hypopigmentation of hair (HP:0011365)1.72632080
114Abnormality of the aortic arch (HP:0012303)1.72584418
115Neoplasm of the oral cavity (HP:0100649)1.72215227
116Meckel diverticulum (HP:0002245)1.72079747
117Hypoplastic female external genitalia (HP:0012815)1.71286201
118Increased nuchal translucency (HP:0010880)1.70578535
119Trigonocephaly (HP:0000243)1.69667673
120Abnormal lung lobation (HP:0002101)1.68419607
121Impaired vibration sensation in the lower limbs (HP:0002166)1.68320717
122Median cleft lip (HP:0000161)1.68094798
123Absent eyebrow (HP:0002223)1.67956712
124Abnormality of the diencephalon (HP:0010662)1.67885404
125Abnormality of the right ventricle (HP:0001707)1.67129550
126Preaxial hand polydactyly (HP:0001177)1.66974835
127Hepatoblastoma (HP:0002884)1.66839334
128Renal hypoplasia (HP:0000089)1.66577560
129Abnormal hair whorl (HP:0010721)1.66576124
130Abnormality of the carotid arteries (HP:0005344)1.66482089
131Focal motor seizures (HP:0011153)1.66169915
132Macroorchidism (HP:0000053)1.65999499
133Abnormal rod and cone electroretinograms (HP:0008323)1.65871389
134Rhabdomyosarcoma (HP:0002859)1.65392144
135Abnormality of the ileum (HP:0001549)1.64808497
136Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.64741273
137Neoplasm of the adrenal cortex (HP:0100641)1.64530665
138Growth hormone deficiency (HP:0000824)1.64228118
139Hyperglycinemia (HP:0002154)1.63858330
140Poor coordination (HP:0002370)1.63464362
141Highly arched eyebrow (HP:0002553)1.63355621
142Renal duplication (HP:0000075)1.63210007
143Genital tract atresia (HP:0001827)1.62946330
144Epileptic encephalopathy (HP:0200134)1.62312220
145Renal dysplasia (HP:0000110)1.62067166
146Abnormality of salivation (HP:0100755)1.62032231
147Abnormality of the renal cortex (HP:0011035)1.61438512
148Vesicoureteral reflux (HP:0000076)1.61298164
149Facial cleft (HP:0002006)1.61236423
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60301839
151Embryonal neoplasm (HP:0002898)1.60257062
152Short tibia (HP:0005736)1.59974231
153Pendular nystagmus (HP:0012043)1.59858016
154Short philtrum (HP:0000322)1.59814016
155Stenosis of the external auditory canal (HP:0000402)1.59740957
156Cutaneous syndactyly (HP:0012725)1.59361003
157Duplication of thumb phalanx (HP:0009942)1.59215397
158Facial hemangioma (HP:0000329)1.58230881
159Abnormality of the septum pellucidum (HP:0007375)1.58144165
160Absent septum pellucidum (HP:0001331)1.57701216
161Acute myeloid leukemia (HP:0004808)1.57665945
162Abnormality of the frontal sinuses (HP:0002687)1.57346492
163Morphological abnormality of the middle ear (HP:0008609)1.57304214
164Congenital primary aphakia (HP:0007707)1.56706262
165Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.56436273
166Deeply set eye (HP:0000490)1.56120743
167Thick eyebrow (HP:0000574)1.55764127
168Tapered finger (HP:0001182)1.55282758
169Ependymoma (HP:0002888)1.54862393
170Vaginal atresia (HP:0000148)1.54746236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.80737518
2TNIK2.99441261
3MAP2K72.77047308
4MAP3K42.54172387
5MAPK132.44287494
6MKNK22.42427677
7CDC72.33498735
8SRPK12.29645241
9WNK42.27984452
10CASK2.23924997
11WNK32.12739035
12MKNK12.10576798
13MAP3K62.01675910
14CLK11.95763654
15CDK31.86611461
16NUAK11.84130024
17BRD41.71013569
18ERBB31.63985942
19TRIM281.61623455
20CAMK1G1.59246162
21TAF11.53943504
22STK161.53265193
23NTRK21.49308321
24SIK21.47942542
25FGFR21.43889112
26CSNK1A1L1.35845349
27SGK21.34157213
28LATS11.30837080
29OXSR11.30734105
30DYRK31.30650663
31FRK1.29946196
32EIF2AK21.27412566
33CDK81.26142541
34NEK61.23821440
35DYRK21.23390987
36ZAK1.21593903
37NEK21.20445217
38NTRK31.19481981
39BRAF1.18774250
40MAP3K101.16118164
41INSRR1.15231941
42ACVR1B1.14725584
43PNCK1.13789687
44CAMK1D1.12966753
45CSNK1E1.11193891
46PRKCG1.10472535
47PKN11.06026560
48YES11.05591917
49CDK91.03546749
50TYRO31.02327184
51BMPR1B1.00869650
52CSNK1G31.00471443
53CSNK1G20.99839071
54PLK10.98853849
55CDK120.98667387
56PIK3CA0.98563266
57DYRK1A0.98523818
58CSNK1G10.97908560
59PLK20.92032862
60PLK40.87458518
61SGK2230.84148076
62SGK4940.84148076
63TTK0.83408668
64ATM0.83399129
65GRK70.83384996
66CHEK20.82626641
67EPHA40.81617177
68SGK30.80352300
69WEE10.79362387
70* ATR0.79197440
71MAP3K90.79004836
72MARK20.77260625
73MAP2K40.72056957
74PINK10.70938699
75CSF1R0.70913621
76UHMK10.69704280
77PRKCI0.68398588
78EPHB20.67809318
79PAK30.67485267
80ADRBK20.66636960
81VRK10.66548824
82SGK10.66065571
83FGR0.65759898
84CDK190.64423253
85CCNB10.62158271
86STK38L0.61401814
87STK110.59536601
88TXK0.59519725
89PLK30.58881841
90MELK0.58196987
91TSSK60.58095030
92CDK10.58065834
93LATS20.57779798
94GRK10.56612790
95CSNK1D0.55889901
96SIK30.54542977
97AURKA0.54084560
98BCR0.54040272
99MAPK140.53883835
100MAP4K20.53315883
101PRKCZ0.53098531
102ALK0.50732310
103STK40.50095580
104CHEK10.50051921
105GSK3B0.49881065
106TGFBR10.49776038
107PRKG10.49325795
108AURKB0.49205420
109TEC0.49064026
110CSNK2A20.49039108
111BRSK20.48224903
112AKT30.47821252
113PRKDC0.47527935
114EIF2AK10.45338993
115CDK20.44967114
116WNK10.44959400
117KIT0.44775561
118TLK10.44517206
119CDK50.43393654
120RPS6KB10.43034776
121RPS6KA20.42507001
122PRKCE0.41959314
123AKT10.40569481
124MAPK100.40550911
125FES0.39487903
126PRPF4B0.38663165
127STK30.38650733
128MUSK0.38173426
129CDK70.37739361
130CAMK40.37029823
131MAPK70.36984195
132MINK10.36055380
133DMPK0.36032388
134ERBB20.35930909
135PRKACB0.35923084
136STK390.35898329
137HIPK20.34133944

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.42719130
2Fanconi anemia pathway_Homo sapiens_hsa034601.91935561
3Nicotine addiction_Homo sapiens_hsa050331.89348652
4Cardiac muscle contraction_Homo sapiens_hsa042601.79384985
5Non-homologous end-joining_Homo sapiens_hsa034501.77975021
6Steroid biosynthesis_Homo sapiens_hsa001001.70684688
7Axon guidance_Homo sapiens_hsa043601.69411812
8RNA transport_Homo sapiens_hsa030131.69207104
9RNA polymerase_Homo sapiens_hsa030201.68475022
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66474532
11Oxidative phosphorylation_Homo sapiens_hsa001901.61195368
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60842938
13Parkinsons disease_Homo sapiens_hsa050121.56098479
14Glutamatergic synapse_Homo sapiens_hsa047241.54783013
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49716564
16Protein export_Homo sapiens_hsa030601.48740255
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45563170
18Morphine addiction_Homo sapiens_hsa050321.43337312
19mRNA surveillance pathway_Homo sapiens_hsa030151.41671842
20Circadian entrainment_Homo sapiens_hsa047131.37367882
21Homologous recombination_Homo sapiens_hsa034401.37146014
22Wnt signaling pathway_Homo sapiens_hsa043101.37141091
23Cell cycle_Homo sapiens_hsa041101.35137284
24Basal transcription factors_Homo sapiens_hsa030221.34676165
25Colorectal cancer_Homo sapiens_hsa052101.29696470
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28250014
27Huntingtons disease_Homo sapiens_hsa050161.26594513
28Serotonergic synapse_Homo sapiens_hsa047261.23978642
29Long-term potentiation_Homo sapiens_hsa047201.19101764
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17885555
31Mismatch repair_Homo sapiens_hsa034301.17715810
32MicroRNAs in cancer_Homo sapiens_hsa052061.16016168
33Basal cell carcinoma_Homo sapiens_hsa052171.15031989
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13698205
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12726385
36Dopaminergic synapse_Homo sapiens_hsa047281.12502271
37Long-term depression_Homo sapiens_hsa047301.12326786
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10862334
39Cholinergic synapse_Homo sapiens_hsa047251.10137687
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09856857
41ErbB signaling pathway_Homo sapiens_hsa040121.07618798
42Taste transduction_Homo sapiens_hsa047421.05920044
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04945623
44Alzheimers disease_Homo sapiens_hsa050101.04816604
45GABAergic synapse_Homo sapiens_hsa047271.04235583
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03985228
47Propanoate metabolism_Homo sapiens_hsa006400.99758595
48Melanogenesis_Homo sapiens_hsa049160.98995734
49Olfactory transduction_Homo sapiens_hsa047400.97166887
50Spliceosome_Homo sapiens_hsa030400.95576990
51Renin secretion_Homo sapiens_hsa049240.95504209
52Endometrial cancer_Homo sapiens_hsa052130.94802404
53cAMP signaling pathway_Homo sapiens_hsa040240.94140761
54Amphetamine addiction_Homo sapiens_hsa050310.93597495
55Ovarian steroidogenesis_Homo sapiens_hsa049130.92853557
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90812414
57RNA degradation_Homo sapiens_hsa030180.90625792
58Oocyte meiosis_Homo sapiens_hsa041140.90010197
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89684957
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89531756
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89372950
62Adherens junction_Homo sapiens_hsa045200.89026521
63DNA replication_Homo sapiens_hsa030300.88430907
64Pancreatic cancer_Homo sapiens_hsa052120.88362013
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88191631
66Prostate cancer_Homo sapiens_hsa052150.88010563
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87804662
68Selenocompound metabolism_Homo sapiens_hsa004500.87425396
69Calcium signaling pathway_Homo sapiens_hsa040200.87126019
70Ras signaling pathway_Homo sapiens_hsa040140.87028366
71Butanoate metabolism_Homo sapiens_hsa006500.86555619
72Alcoholism_Homo sapiens_hsa050340.86112682
73Cocaine addiction_Homo sapiens_hsa050300.85013965
74Hedgehog signaling pathway_Homo sapiens_hsa043400.83760813
75GnRH signaling pathway_Homo sapiens_hsa049120.83530519
76MAPK signaling pathway_Homo sapiens_hsa040100.83477759
77Oxytocin signaling pathway_Homo sapiens_hsa049210.83426556
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83418564
79Notch signaling pathway_Homo sapiens_hsa043300.82914789
80Lysine degradation_Homo sapiens_hsa003100.82586913
81Ether lipid metabolism_Homo sapiens_hsa005650.82346250
82Phototransduction_Homo sapiens_hsa047440.82320878
83Choline metabolism in cancer_Homo sapiens_hsa052310.81684549
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80690654
85Glioma_Homo sapiens_hsa052140.79615062
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79167395
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.77663287
88Base excision repair_Homo sapiens_hsa034100.76586232
89Type II diabetes mellitus_Homo sapiens_hsa049300.76520777
90TGF-beta signaling pathway_Homo sapiens_hsa043500.76502354
91Pathways in cancer_Homo sapiens_hsa052000.76384114
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75748839
93Hippo signaling pathway_Homo sapiens_hsa043900.75052944
94Rap1 signaling pathway_Homo sapiens_hsa040150.74390175
95Non-small cell lung cancer_Homo sapiens_hsa052230.73854257
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73502650
97Fatty acid biosynthesis_Homo sapiens_hsa000610.72819847
98FoxO signaling pathway_Homo sapiens_hsa040680.72811681
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72667106
100Platelet activation_Homo sapiens_hsa046110.72026001
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71945011
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71873712
103Melanoma_Homo sapiens_hsa052180.71694550
104Herpes simplex infection_Homo sapiens_hsa051680.71669551
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71551078
106Insulin secretion_Homo sapiens_hsa049110.71543921
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70099536
108Dorso-ventral axis formation_Homo sapiens_hsa043200.69857564
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69576669
110Purine metabolism_Homo sapiens_hsa002300.69150887
111Salivary secretion_Homo sapiens_hsa049700.69042542
112Nucleotide excision repair_Homo sapiens_hsa034200.68591734
113Linoleic acid metabolism_Homo sapiens_hsa005910.68470642
114Small cell lung cancer_Homo sapiens_hsa052220.68388845
115Gap junction_Homo sapiens_hsa045400.68047827
116Circadian rhythm_Homo sapiens_hsa047100.66623325
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66194819
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.66091161
119Pyrimidine metabolism_Homo sapiens_hsa002400.65432960
120Chemokine signaling pathway_Homo sapiens_hsa040620.65348246
121T cell receptor signaling pathway_Homo sapiens_hsa046600.65005382
122Estrogen signaling pathway_Homo sapiens_hsa049150.64244217
123Primary immunodeficiency_Homo sapiens_hsa053400.64197881
124Gastric acid secretion_Homo sapiens_hsa049710.63036354
125Systemic lupus erythematosus_Homo sapiens_hsa053220.62995182
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.62577681
127Chronic myeloid leukemia_Homo sapiens_hsa052200.61791211
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.60981457
129Viral myocarditis_Homo sapiens_hsa054160.60699415
130Renal cell carcinoma_Homo sapiens_hsa052110.59391472
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59384058
132Synaptic vesicle cycle_Homo sapiens_hsa047210.58712507
133Tryptophan metabolism_Homo sapiens_hsa003800.58635506
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57639073
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56203473
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.55638163
137Retinol metabolism_Homo sapiens_hsa008300.51587918
138beta-Alanine metabolism_Homo sapiens_hsa004100.47626153
139Tight junction_Homo sapiens_hsa045300.47415722
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47266202
141One carbon pool by folate_Homo sapiens_hsa006700.46435907
142Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45417245
143Pyruvate metabolism_Homo sapiens_hsa006200.43894474

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