PHF12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.93439850
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54922722
3antigen processing and presentation of endogenous antigen (GO:0019883)4.33652787
4negative regulation of histone methylation (GO:0031061)4.26020576
5cytoplasmic mRNA processing body assembly (GO:0033962)4.15811932
6positive regulation of histone deacetylation (GO:0031065)4.15492996
7regulation of B cell receptor signaling pathway (GO:0050855)4.12578897
8mitotic sister chromatid cohesion (GO:0007064)4.10282468
9positive regulation by symbiont of host defense response (GO:0052509)3.99842457
10modulation by symbiont of host defense response (GO:0052031)3.99842457
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.99842457
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.99842457
13positive regulation by organism of defense response of other organism involved in symbiotic interact3.99842457
14modulation by symbiont of host immune response (GO:0052553)3.99842457
15heterochromatin organization (GO:0070828)3.94478983
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.88502032
17histone H3-K4 methylation (GO:0051568)3.83247160
18cellular extravasation (GO:0045123)3.70181577
19negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.68953552
20tolerance induction (GO:0002507)3.68855651
21positive regulation of gamma-delta T cell activation (GO:0046645)3.68121306
22histone H3-K4 trimethylation (GO:0080182)3.67706249
23glucocorticoid receptor signaling pathway (GO:0042921)3.66207317
24nuclear pore complex assembly (GO:0051292)3.64282079
25positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.62805971
26mRNA stabilization (GO:0048255)3.60886677
27RNA stabilization (GO:0043489)3.60886677
28leukocyte aggregation (GO:0070486)3.59728081
29response to interleukin-15 (GO:0070672)3.56923544
30response to muramyl dipeptide (GO:0032495)3.54642180
31positive regulation of gene expression, epigenetic (GO:0045815)3.53571065
32histone H4-K16 acetylation (GO:0043984)3.52477453
33histone H4-K12 acetylation (GO:0043983)3.51256640
34regulation of gamma-delta T cell differentiation (GO:0045586)3.48593734
35regulation of RNA export from nucleus (GO:0046831)3.45507927
36positive regulation of granulocyte differentiation (GO:0030854)3.44518771
37protein localization to kinetochore (GO:0034501)3.43573643
38B cell receptor signaling pathway (GO:0050853)3.40888634
39DNA unwinding involved in DNA replication (GO:0006268)3.34663381
40intracellular estrogen receptor signaling pathway (GO:0030520)3.32769919
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.30926329
42histone lysine demethylation (GO:0070076)3.29673976
43macrophage activation involved in immune response (GO:0002281)3.29396261
44negative regulation of mRNA processing (GO:0050686)3.26479178
45detection of other organism (GO:0098543)3.25486804
46nuclear pore organization (GO:0006999)3.24641908
47regulation of histone H3-K9 methylation (GO:0051570)3.23313823
48corticosteroid receptor signaling pathway (GO:0031958)3.23158315
49chromatin assembly (GO:0031497)3.20485573
50mitotic chromosome condensation (GO:0007076)3.20462339
51histone H4-K5 acetylation (GO:0043981)3.19621329
52histone H4-K8 acetylation (GO:0043982)3.19621329
53histone demethylation (GO:0016577)3.18841845
54detection of bacterium (GO:0016045)3.17860837
55negative regulation of mRNA metabolic process (GO:1903312)3.17591268
56positive regulation of protein deacetylation (GO:0090312)3.17544218
57negative regulation of RNA splicing (GO:0033119)3.17292553
58regulation of sister chromatid cohesion (GO:0007063)3.16638930
59negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.15676117
60negative regulation of cell killing (GO:0031342)3.15676117
61mannose metabolic process (GO:0006013)3.15668395
62cellular response to interleukin-15 (GO:0071350)3.15497356
63positive thymic T cell selection (GO:0045059)3.14768574
64regulation of gamma-delta T cell activation (GO:0046643)3.12325839
65regulation of histone H3-K27 methylation (GO:0061085)3.10757650
66response to peptidoglycan (GO:0032494)3.10271777
67activated T cell proliferation (GO:0050798)3.06936388
68DNA duplex unwinding (GO:0032508)3.03490385
69negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.02674223
70histone lysine methylation (GO:0034968)3.01234378
71negative regulation of T cell mediated immunity (GO:0002710)3.00750423
72NLS-bearing protein import into nucleus (GO:0006607)2.99903538
73DNA geometric change (GO:0032392)2.99350121
74negative regulation of leukocyte mediated immunity (GO:0002704)2.98579577
75nucleosome disassembly (GO:0006337)2.98224117
76protein-DNA complex disassembly (GO:0032986)2.98224117
77histone H2A monoubiquitination (GO:0035518)2.98105051
783-UTR-mediated mRNA stabilization (GO:0070935)2.97520733
79histone H3-K9 modification (GO:0061647)2.96758047
80peptidyl-lysine trimethylation (GO:0018023)2.93639675
81sister chromatid segregation (GO:0000819)2.93155776
82dosage compensation (GO:0007549)2.92155140
83germinal center formation (GO:0002467)2.91663320
84protein localization to chromosome, centromeric region (GO:0071459)2.90866158
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90750013
86response to host (GO:0075136)2.90750013
87response to host defenses (GO:0052200)2.90750013
88mitotic nuclear envelope disassembly (GO:0007077)2.90042818
89regulation of nucleobase-containing compound transport (GO:0032239)2.87967445
90response to host immune response (GO:0052572)2.87881038
91response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.87881038
92positive regulation of CREB transcription factor activity (GO:0032793)2.86620064
93regulation of interferon-beta biosynthetic process (GO:0045357)2.85468327
94negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.85379473
95negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.85050439
96positive T cell selection (GO:0043368)2.84888523
97regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.84326265
98regulation of mRNA stability (GO:0043488)2.84228730
99regulation of translational fidelity (GO:0006450)2.83871902
100histone methylation (GO:0016571)2.81442887
101peptidyl-lysine dimethylation (GO:0018027)2.81124465
102negative regulation of T-helper cell differentiation (GO:0045623)2.80899260
103negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.80899260
104protein dealkylation (GO:0008214)2.80713566
105protein demethylation (GO:0006482)2.80713566
106histone H4 acetylation (GO:0043967)2.78855807
107negative regulation of gene expression, epigenetic (GO:0045814)2.77947585
108negative regulation of histone modification (GO:0031057)2.77477712
109positive regulation of RNA splicing (GO:0033120)2.77443726
110alternative mRNA splicing, via spliceosome (GO:0000380)2.77419401
111regulation of histone H3-K4 methylation (GO:0051569)2.76630569
112neutrophil activation (GO:0042119)2.74433347
113megakaryocyte development (GO:0035855)2.72891758
114regulation of B cell differentiation (GO:0045577)2.72806308
115phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.72463382
116regulation of granulocyte differentiation (GO:0030852)2.72252143
117nuclear envelope disassembly (GO:0051081)2.71896786
118membrane disassembly (GO:0030397)2.71896786
119chromatin silencing (GO:0006342)2.71806570
120mitotic sister chromatid segregation (GO:0000070)2.71541312
121detection of external biotic stimulus (GO:0098581)2.71138941
122gene silencing (GO:0016458)2.70570854
123thymic T cell selection (GO:0045061)2.70429910
124regulation of NFAT protein import into nucleus (GO:0051532)2.70204533
125regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.69900280
126DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.68741254
127T cell homeostasis (GO:0043029)2.68704405
128regulation of RNA stability (GO:0043487)2.68278872
129antigen processing and presentation via MHC class Ib (GO:0002475)2.65198327
130neutrophil activation involved in immune response (GO:0002283)2.64885323
131trophectodermal cell differentiation (GO:0001829)2.63981539
132regulation of histone methylation (GO:0031060)2.63814177
133regulation of T cell tolerance induction (GO:0002664)2.63807279
134negative regulation of erythrocyte differentiation (GO:0045647)2.63104177
135positive regulation of Rap GTPase activity (GO:0032854)2.61977235
136negative regulation of cAMP-mediated signaling (GO:0043951)2.61796235
137nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.61626990
138regulation of ARF protein signal transduction (GO:0032012)2.61318388
139histone H3 acetylation (GO:0043966)2.60483691
140negative T cell selection (GO:0043383)2.60177376
141positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.60121770
142detection of molecule of bacterial origin (GO:0032490)2.59699326
143negative regulation of chromatin modification (GO:1903309)2.59438922
144T cell selection (GO:0045058)2.59268627
145histone H3-K36 demethylation (GO:0070544)2.58425287
146negative regulation of translation, ncRNA-mediated (GO:0040033)2.58403017
147regulation of translation, ncRNA-mediated (GO:0045974)2.58403017
148negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.58403017
149positive regulation of chromosome segregation (GO:0051984)2.58100376
150histone acetylation (GO:0016573)2.57385255
151T cell migration (GO:0072678)2.56600019
152peptidyl-lysine methylation (GO:0018022)2.56185741
153positive regulation of mitotic sister chromatid separation (GO:1901970)2.55763839
154positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.55763839
155positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.55763839
156pore complex assembly (GO:0046931)2.55287965
157positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.54672157
158regulation of hippo signaling (GO:0035330)2.54598015
159gene silencing by RNA (GO:0031047)2.54473711
160negative thymic T cell selection (GO:0045060)2.54230409
161internal peptidyl-lysine acetylation (GO:0018393)2.53730253
162negative regulation of interleukin-12 production (GO:0032695)2.53198191
163B cell homeostasis (GO:0001782)2.52836659
164response to laminar fluid shear stress (GO:0034616)2.51468795
165histone H3-K9 demethylation (GO:0033169)2.50514994
166regulation of mast cell degranulation (GO:0043304)2.50351358
167regulation of leukocyte degranulation (GO:0043300)2.50175853
168natural killer cell differentiation (GO:0001779)2.49528434
169regulation of tolerance induction (GO:0002643)2.48093252
170neutrophil mediated immunity (GO:0002446)2.47907718
171positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.47682392
172regulation of DNA damage checkpoint (GO:2000001)2.47048630
173histone mRNA catabolic process (GO:0071044)2.46554625
174antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.45258768
175antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.45258768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.55619183
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.56707730
3MYC_22102868_ChIP-Seq_BL_Human4.53750694
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.15383232
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.68496183
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.42245050
7* VDR_21846776_ChIP-Seq_THP-1_Human3.02688796
8TCF7_22412390_ChIP-Seq_EML_Mouse2.86214666
9* KDM2B_26808549_Chip-Seq_DND41_Human2.57678777
10KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.54545634
11* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.50724820
12* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42783382
13* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.38399082
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.35489118
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.27499877
16CIITA_25753668_ChIP-Seq_RAJI_Human2.26382780
17* UTX_26944678_Chip-Seq_JUKART_Human2.12626274
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04984315
19MAF_26560356_Chip-Seq_TH1_Human2.04831558
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00180811
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.99392565
22SCL_19346495_ChIP-Seq_HPC-7_Human1.96794394
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.88271608
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.82077256
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80936074
26* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80630400
27* ELK3_25401928_ChIP-Seq_HUVEC_Human1.79475536
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75011974
29MYB_26560356_Chip-Seq_TH1_Human1.74586296
30* KDM2B_26808549_Chip-Seq_JURKAT_Human1.73350120
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71777142
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71350733
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68719491
34* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.68454697
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66993844
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.64906509
37* MYB_26560356_Chip-Seq_TH2_Human1.62952676
38* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62466843
39VDR_24763502_ChIP-Seq_THP-1_Human1.60576569
40GATA3_27048872_Chip-Seq_THYMUS_Human1.57612211
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56748610
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53400970
43* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.52846404
44* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51724295
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50760501
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49244491
47NCOR1_26117541_ChIP-Seq_K562_Human1.48654781
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46554622
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44679644
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43476542
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42810714
52* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41928594
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41898221
54GATA1_19941826_ChIP-Seq_K562_Human1.40701063
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38797267
56* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38251384
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.37171852
58* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35343927
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34534869
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33904730
61KDM2B_26808549_Chip-Seq_K562_Human1.31824816
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31541859
63VDR_24787735_ChIP-Seq_THP-1_Human1.30950619
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29672427
65* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29176848
66* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.29160938
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28949716
68MAF_26560356_Chip-Seq_TH2_Human1.28870752
69SPI1_23127762_ChIP-Seq_K562_Human1.28439792
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28200615
71* KDM5A_27292631_Chip-Seq_BREAST_Human1.27843616
72* RUNX1_22412390_ChIP-Seq_EML_Mouse1.26948042
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26106229
74RUNX_20019798_ChIP-Seq_JUKART_Human1.25600561
75* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22640334
76LXR_22292898_ChIP-Seq_THP-1_Human1.20962879
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20535332
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.18240003
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.17958254
80* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16954180
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16924746
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16484860
83* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16162531
84* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15285586
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13594700
86* NANOG_21062744_ChIP-ChIP_HESCs_Human1.11611258
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11520254
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.10621070
89* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10573752
90STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08947857
91* RACK7_27058665_Chip-Seq_MCF-7_Human1.08651650
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08348604
93* PU_27001747_Chip-Seq_BMDM_Mouse1.07896954
94DROSHA_22980978_ChIP-Seq_HELA_Human1.05419859
95* CHD1_26751641_Chip-Seq_LNCaP_Human1.05341636
96MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04956273
97* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04861938
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03621319
99GATA2_19941826_ChIP-Seq_K562_Human1.03490726
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02497277
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02497277
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02497277
103SMC4_20622854_ChIP-Seq_HELA_Human1.01453180
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01199272
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00307215
106SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00138096
107NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99495624
108P68_20966046_ChIP-Seq_HELA_Human0.98347873
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98074247
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97839921
111* CREB1_26743006_Chip-Seq_LNCaP_Human0.97311492
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96966358
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.96799380
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96001819
115* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95759092
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95480184
117SPI1_23547873_ChIP-Seq_NB4_Human0.94635036
118* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94193102
119GATA1_19941827_ChIP-Seq_MEL_Mouse0.93993957
120* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93321547
121NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93312571
122CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92952763
123* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92843356
124* SA1_27219007_Chip-Seq_ERYTHROID_Human0.92830855
125BCOR_27268052_Chip-Seq_Bcells_Human0.92726138
126BP1_19119308_ChIP-ChIP_Hs578T_Human0.92388760
127MYC_18555785_ChIP-Seq_MESCs_Mouse0.91974289
128* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91832299
129* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91243029
130EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90881419
131* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90702352
132Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89911546
133ATF3_27146783_Chip-Seq_COLON_Human0.89689244
134* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89167707
135PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88522226
136GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88404944
137GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87636810
138* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87469997
139GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86238556
140ELF1_20517297_ChIP-Seq_JURKAT_Human0.84452420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.67928095
2MP0005076_abnormal_cell_differentiation2.98134881
3MP0003724_increased_susceptibility_to2.90120432
4MP0001835_abnormal_antigen_presentation2.81838340
5MP0002009_preneoplasia2.79810632
6MP0002396_abnormal_hematopoietic_system2.76561389
7MP0008057_abnormal_DNA_replication2.69880780
8MP0010352_gastrointestinal_tract_polyps2.59360775
9MP0009278_abnormal_bone_marrow2.56753743
10MP0003705_abnormal_hypodermis_morpholog2.48186508
11MP0003111_abnormal_nucleus_morphology2.44349190
12MP0001873_stomach_inflammation2.37682219
13MP0010094_abnormal_chromosome_stability2.33011891
14MP0003077_abnormal_cell_cycle2.32224989
15MP0004808_abnormal_hematopoietic_stem2.28751594
16MP0002419_abnormal_innate_immunity2.25452536
17MP0005000_abnormal_immune_tolerance2.18919374
18MP0004381_abnormal_hair_follicle2.13343413
19MP0005025_abnormal_response_to2.11517929
20MP0003172_abnormal_lysosome_physiology2.10749679
21MP0003300_gastrointestinal_ulcer2.09852369
22MP0000569_abnormal_digit_pigmentation2.05032847
23MP0004947_skin_inflammation2.01231474
24MP0000350_abnormal_cell_proliferation1.95683163
25MP0004957_abnormal_blastocyst_morpholog1.95034039
26MP0003763_abnormal_thymus_physiology1.91680275
27MP0003303_peritoneal_inflammation1.89140478
28MP0003787_abnormal_imprinting1.86042304
29MP0001730_embryonic_growth_arrest1.85523700
30MP0000703_abnormal_thymus_morphology1.83922420
31MP0001545_abnormal_hematopoietic_system1.82671278
32MP0005397_hematopoietic_system_phenotyp1.82671278
33MP0003693_abnormal_embryo_hatching1.82657519
34MP0003984_embryonic_growth_retardation1.82251474
35MP0005310_abnormal_salivary_gland1.81171462
36MP0005380_embryogenesis_phenotype1.80777942
37MP0001672_abnormal_embryogenesis/_devel1.80777942
38MP0002088_abnormal_embryonic_growth/wei1.79550143
39MP0008961_abnormal_basal_metabolism1.78546476
40MP0002398_abnormal_bone_marrow1.77588946
41MP0002086_abnormal_extraembryonic_tissu1.72574309
42MP0003121_genomic_imprinting1.72280273
43MP0010307_abnormal_tumor_latency1.69964389
44MP0002084_abnormal_developmental_patter1.68878586
45MP0002138_abnormal_hepatobiliary_system1.66323347
46MP0004197_abnormal_fetal_growth/weight/1.66031577
47MP0001849_ear_inflammation1.65719284
48MP0005451_abnormal_body_composition1.64116347
49MP0000685_abnormal_immune_system1.60068935
50MP0001697_abnormal_embryo_size1.59977695
51MP0008260_abnormal_autophagy1.59200529
52MP0003123_paternal_imprinting1.59092670
53MP0002085_abnormal_embryonic_tissue1.57286017
54MP0003866_abnormal_defecation1.51485386
55MP0003183_abnormal_peptide_metabolism1.51469503
56MP0001800_abnormal_humoral_immune1.49778823
57MP0004185_abnormal_adipocyte_glucose1.48936016
58MP0000733_abnormal_muscle_development1.46760603
59MP0003890_abnormal_embryonic-extraembry1.46477432
60MP0002132_abnormal_respiratory_system1.46374187
61MP0001533_abnormal_skeleton_physiology1.42704628
62MP0002653_abnormal_ependyma_morphology1.42298499
63MP0002722_abnormal_immune_system1.41172119
64MP0000689_abnormal_spleen_morphology1.38724643
65MP0004264_abnormal_extraembryonic_tissu1.35146113
66MP0002080_prenatal_lethality1.34487408
67MP0002925_abnormal_cardiovascular_devel1.34290320
68MP0009785_altered_susceptibility_to1.32915972
69MP0001915_intracranial_hemorrhage1.32091901
70MP0004858_abnormal_nervous_system1.30972512
71MP0009703_decreased_birth_body1.28558192
72MP0003567_abnormal_fetal_cardiomyocyte1.28007386
73MP0003566_abnormal_cell_adhesion1.24773449
74MP0000716_abnormal_immune_system1.24274322
75MP0001851_eye_inflammation1.24117709
76MP0008877_abnormal_DNA_methylation1.23579667
77MP0009672_abnormal_birth_weight1.23389160
78MP0002166_altered_tumor_susceptibility1.21457398
79MP0003045_fibrosis1.20641952
80MP0000490_abnormal_crypts_of1.20605591
81MP0005464_abnormal_platelet_physiology1.20488237
82MP0002998_abnormal_bone_remodeling1.18951165
83MP0002019_abnormal_tumor_incidence1.18917297
84MP0001790_abnormal_immune_system1.18355979
85MP0005387_immune_system_phenotype1.18355979
86MP0003119_abnormal_digestive_system1.17260032
87MP0009333_abnormal_splenocyte_physiolog1.16106705
88MP0002429_abnormal_blood_cell1.14928722
89MP0001845_abnormal_inflammatory_respons1.14471652
90MP0010630_abnormal_cardiac_muscle1.13988309
91MP0002877_abnormal_melanocyte_morpholog1.12527278
92MP0003935_abnormal_craniofacial_develop1.12212918
93MP0000428_abnormal_craniofacial_morphol1.09285731
94MP0003191_abnormal_cellular_cholesterol1.07624489
95MP0005409_darkened_coat_color1.06927785
96MP0008770_decreased_survivor_rate1.06880633
97MP0000266_abnormal_heart_morphology1.06716945
98MP0000313_abnormal_cell_death1.06682519
99MP0008007_abnormal_cellular_replicative1.06426533
100MP0002148_abnormal_hypersensitivity_rea1.05693728
101MP0002452_abnormal_antigen_presenting1.04246052
102MP0002420_abnormal_adaptive_immunity1.03196774
103MP0003091_abnormal_cell_migration1.02213932
104MP0004130_abnormal_muscle_cell1.01071674
105MP0001819_abnormal_immune_cell1.01068133
106MP0002933_joint_inflammation0.99989877
107MP0006054_spinal_hemorrhage0.98494127
108MP0005023_abnormal_wound_healing0.98382696
109MP0002405_respiratory_system_inflammati0.97248484
110MP0001293_anophthalmia0.96321825
111MP0002092_abnormal_eye_morphology0.92554778
112MP0001784_abnormal_fluid_regulation0.91362523
113MP0003115_abnormal_respiratory_system0.90688936
114MP0000015_abnormal_ear_pigmentation0.90533571
115MP0005075_abnormal_melanosome_morpholog0.90327337
116MP0010234_abnormal_vibrissa_follicle0.89756987
117MP0008058_abnormal_DNA_repair0.89582423
118MP0001853_heart_inflammation0.89440235
119MP0002277_abnormal_respiratory_mucosa0.87483661
120MP0009115_abnormal_fat_cell0.87293146
121MP0000858_altered_metastatic_potential0.86990744
122MP0002723_abnormal_immune_serum0.85688626
123MP0010155_abnormal_intestine_physiology0.85054641
124MP0005621_abnormal_cell_physiology0.84572701
125MP0002006_tumorigenesis0.84469884
126MP0005666_abnormal_adipose_tissue0.84033021
127MP0001348_abnormal_lacrimal_gland0.83909773
128MP0009053_abnormal_anal_canal0.83381954
129MP0003943_abnormal_hepatobiliary_system0.83363952
130MP0008469_abnormal_protein_level0.82398751
131MP0002928_abnormal_bile_duct0.81556673
132MP0000432_abnormal_head_morphology0.81166299
133MP0000537_abnormal_urethra_morphology0.78204574
134MP0003122_maternal_imprinting0.76651756
135MP0004883_abnormal_blood_vessel0.76459811
136MP0003828_pulmonary_edema0.76025046
137MP0000767_abnormal_smooth_muscle0.75048339
138MP0005671_abnormal_response_to0.74943130
139MP0000470_abnormal_stomach_morphology0.74189207
140MP0000477_abnormal_intestine_morphology0.73585705
141MP0006082_CNS_inflammation0.73140120
142MP0005083_abnormal_biliary_tract0.72061807
143MP0004233_abnormal_muscle_weight0.71817999
144MP0010368_abnormal_lymphatic_system0.71533400
145MP0000465_gastrointestinal_hemorrhage0.69178139
146MP0002249_abnormal_larynx_morphology0.67415599
147MP0001986_abnormal_taste_sensitivity0.65226988
148MP0004510_myositis0.64153587
149MP0002822_catalepsy0.63370731
150MP0001663_abnormal_digestive_system0.62973036
151MP0003656_abnormal_erythrocyte_physiolo0.60465683
152MP0005390_skeleton_phenotype0.59416731
153MP0005375_adipose_tissue_phenotype0.56558603
154MP0008995_early_reproductive_senescence0.56184182
155MP0005220_abnormal_exocrine_pancreas0.55225820
156MP0009931_abnormal_skin_appearance0.55201150
157MP0002970_abnormal_white_adipose0.54877579

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.83648506
2Eczematoid dermatitis (HP:0000976)4.71337977
3Recurrent abscess formation (HP:0002722)3.71174992
4Obstructive sleep apnea (HP:0002870)3.65489396
5Recurrent bacterial skin infections (HP:0005406)3.60703668
6Recurrent fungal infections (HP:0002841)3.51859380
7Myositis (HP:0100614)3.50156937
8Hyperacusis (HP:0010780)3.37890259
9Stomatitis (HP:0010280)3.29137454
10Elevated erythrocyte sedimentation rate (HP:0003565)3.27352499
11Increased IgE level (HP:0003212)3.12972864
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.08563607
13Short 4th metacarpal (HP:0010044)3.08563607
14Ependymoma (HP:0002888)3.02968501
15Orchitis (HP:0100796)2.97855042
16Gastrointestinal infarctions (HP:0005244)2.94810277
17Spontaneous hematomas (HP:0007420)2.93706683
18Long eyelashes (HP:0000527)2.93147398
19Mediastinal lymphadenopathy (HP:0100721)2.93111414
20Abnormality of macrophages (HP:0004311)2.92435326
21Genetic anticipation (HP:0003743)2.89846849
22Meningitis (HP:0001287)2.89362929
23Volvulus (HP:0002580)2.86729592
24Recurrent cutaneous fungal infections (HP:0011370)2.86718401
25Chronic mucocutaneous candidiasis (HP:0002728)2.86718401
26Retrobulbar optic neuritis (HP:0100654)2.79780859
27Optic neuritis (HP:0100653)2.79780859
28Gingivitis (HP:0000230)2.75031156
29Macroorchidism (HP:0000053)2.73164660
30Prolonged bleeding time (HP:0003010)2.72190832
31Abnormality of the columella (HP:0009929)2.69389429
32Pustule (HP:0200039)2.66146712
33Papilledema (HP:0001085)2.65572953
34Hypochromic microcytic anemia (HP:0004840)2.61932270
35Chest pain (HP:0100749)2.60458049
36Neonatal hypoglycemia (HP:0001998)2.59487452
37Hypochromic anemia (HP:0001931)2.57837400
38Astrocytoma (HP:0009592)2.55733808
39Abnormality of the astrocytes (HP:0100707)2.55733808
40Increased nuchal translucency (HP:0010880)2.53975466
41Broad face (HP:0000283)2.53390550
42Cerebral aneurysm (HP:0004944)2.53088777
43Recurrent skin infections (HP:0001581)2.51274131
44Obstructive lung disease (HP:0006536)2.50964544
45Chronic obstructive pulmonary disease (HP:0006510)2.50964544
46Slow saccadic eye movements (HP:0000514)2.47976992
47Supernumerary ribs (HP:0005815)2.47883330
48Basal cell carcinoma (HP:0002671)2.45955939
49Neoplasm of the oral cavity (HP:0100649)2.45583194
50Vasculitis (HP:0002633)2.44101719
51Renal duplication (HP:0000075)2.39011044
52Encephalitis (HP:0002383)2.37066358
53Trigonocephaly (HP:0000243)2.36494154
54Narrow palate (HP:0000189)2.34286396
55Elfin facies (HP:0004428)2.34165144
56Recurrent gram-negative bacterial infections (HP:0005420)2.33911217
57Abnormality of the 4th metacarpal (HP:0010012)2.29163727
58Renovascular hypertension (HP:0100817)2.27540496
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.27433057
60Sparse lateral eyebrow (HP:0005338)2.24777295
61Prominent nose (HP:0000448)2.24501608
62Heterotopia (HP:0002282)2.21980440
63Recurrent viral infections (HP:0004429)2.21213560
64Medulloblastoma (HP:0002885)2.20470350
65Abnormality of T cells (HP:0002843)2.18393169
66Neoplasm of striated muscle (HP:0009728)2.18079842
67Shallow orbits (HP:0000586)2.16053567
68Ulnar bowing (HP:0003031)2.14731675
69Acute lymphatic leukemia (HP:0006721)2.14148972
70Subacute progressive viral hepatitis (HP:0006572)2.13431300
71Syringomyelia (HP:0003396)2.12345401
72Spinal cord lesions (HP:0100561)2.12345401
73Viral hepatitis (HP:0006562)2.11104514
74Supernumerary bones of the axial skeleton (HP:0009144)2.10568322
75Skin tags (HP:0010609)2.10348266
76Arterial thrombosis (HP:0004420)2.08870814
77Obsessive-compulsive behavior (HP:0000722)2.04695580
78Vertebral arch anomaly (HP:0008438)2.03509646
79Persistence of primary teeth (HP:0006335)2.03312336
80Broad palm (HP:0001169)2.02141167
81Rectal prolapse (HP:0002035)2.02110254
82Epistaxis (HP:0000421)2.02049824
83Cellulitis (HP:0100658)2.00824739
84Hemoptysis (HP:0002105)2.00720221
85Lymphopenia (HP:0001888)1.99768911
86Urethral obstruction (HP:0000796)1.98757095
87Overriding aorta (HP:0002623)1.97471094
88Hematochezia (HP:0002573)1.96561875
89Gastrointestinal carcinoma (HP:0002672)1.95531489
90Malignant gastrointestinal tract tumors (HP:0006749)1.95531489
91T lymphocytopenia (HP:0005403)1.95352485
92Segmental peripheral demyelination/remyelination (HP:0003481)1.95009485
93Leukocytosis (HP:0001974)1.94478067
94Truncal obesity (HP:0001956)1.94098978
95Increased density of long bones (HP:0006392)1.92817116
96Germ cell neoplasia (HP:0100728)1.91391427
97Abnormality of the radial head (HP:0003995)1.89430437
98High pitched voice (HP:0001620)1.89329679
99Deviation of the thumb (HP:0009603)1.89275794
100Acute myeloid leukemia (HP:0004808)1.88969042
101Broad thumb (HP:0011304)1.88589413
102Glioma (HP:0009733)1.88037896
103Bowel diverticulosis (HP:0005222)1.87553724
104Proximal placement of thumb (HP:0009623)1.87455815
105Colitis (HP:0002583)1.87269669
106Anal stenosis (HP:0002025)1.86593521
107Abnormality of the lower motor neuron (HP:0002366)1.86255268
108Deep palmar crease (HP:0006191)1.86032568
109Dysmetric saccades (HP:0000641)1.86014633
110Granulocytopenia (HP:0001913)1.85978238
111Urticaria (HP:0001025)1.85876736
112Gastrointestinal inflammation (HP:0004386)1.85445160
113Keratoconjunctivitis sicca (HP:0001097)1.84382783
114Pulmonary infiltrates (HP:0002113)1.83550323
115Pointed chin (HP:0000307)1.83403761
116Abnormality of cells of the lymphoid lineage (HP:0012140)1.82983172
117Clumsiness (HP:0002312)1.82301808
118Papilloma (HP:0012740)1.82267491
119Verrucae (HP:0200043)1.82267491
120Panhypogammaglobulinemia (HP:0003139)1.82003591
121Neoplasm of the heart (HP:0100544)1.81739393
122Short 5th finger (HP:0009237)1.81356982
123Ectopic kidney (HP:0000086)1.81326212
124Insomnia (HP:0100785)1.81205433
125Abnormal delayed hypersensitivity skin test (HP:0002963)1.80691485
126Abnormality of T cell physiology (HP:0011840)1.79749060
127Sandal gap (HP:0001852)1.78323014
128Metaphyseal cupping (HP:0003021)1.76901252
129Deep philtrum (HP:0002002)1.76502539
130Short phalanx of the thumb (HP:0009660)1.76285248
131Rhabdomyosarcoma (HP:0002859)1.75647662
132Cutis marmorata (HP:0000965)1.74930777
133Recurrent bronchitis (HP:0002837)1.74758824
134Abnormality of the diencephalon (HP:0010662)1.74141178
135Hypoplasia of the maxilla (HP:0000327)1.73987641
136Inflammation of the large intestine (HP:0002037)1.73617727
137Abnormality of T cell number (HP:0011839)1.73576654
138Intestinal fistula (HP:0100819)1.72873522
139Gingival bleeding (HP:0000225)1.72610776
140Osteomyelitis (HP:0002754)1.71977981
141Abnormality of the distal phalanx of the thumb (HP:0009617)1.71547851
142Long palpebral fissure (HP:0000637)1.71464042
143Absent frontal sinuses (HP:0002688)1.71224013
144Facial hemangioma (HP:0000329)1.70995383
145Abnormality of the nasal septum (HP:0000419)1.70542608
146Tented upper lip vermilion (HP:0010804)1.70461841
147Microcytic anemia (HP:0001935)1.69754123
148Pulmonary embolism (HP:0002204)1.69577828
149Genu recurvatum (HP:0002816)1.68840288
150Onion bulb formation (HP:0003383)1.68779678
151Episodic fever (HP:0001954)1.68555802
152Increased neuronal autofluorescent lipopigment (HP:0002074)1.68273152
153Keratoconjunctivitis (HP:0001096)1.68215909
154Limited elbow extension (HP:0001377)1.68003758
155Pseudobulbar signs (HP:0002200)1.67545289
156Cafe-au-lait spot (HP:0000957)1.67383159
157Mitral valve prolapse (HP:0001634)1.67339934
158Preauricular skin tag (HP:0000384)1.66600136
159Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66330391
160Stomach cancer (HP:0012126)1.66316714
161Nasal polyposis (HP:0100582)1.65887371
162Lip pit (HP:0100267)1.65524719
163Abnormality of the intervertebral disk (HP:0005108)1.65504329
164Spondylolisthesis (HP:0003302)1.65200493
165Agammaglobulinemia (HP:0004432)1.64370162
166Abnormal number of incisors (HP:0011064)1.63212354
167Dislocated radial head (HP:0003083)1.62895865
168Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.62412125
169Enlarged penis (HP:0000040)1.62303241
170Autoimmune thrombocytopenia (HP:0001973)1.62234768
171Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.62066243
172Increased cerebral lipofuscin (HP:0011813)1.61638666
173Rib fusion (HP:0000902)1.61474937
174Ankyloglossia (HP:0010296)1.61297694
175Gastrointestinal stroma tumor (HP:0100723)1.61234913
176Skull defect (HP:0001362)1.60931553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.62972720
2MAP3K103.70580771
3EEF2K3.36072451
4TRIB33.06602490
5RIPK42.89052089
6MAP4K12.76556126
7PRPF4B2.58616234
8PKN22.37253695
9CDC72.22807231
10BRD42.20002423
11NEK22.16800028
12SIK21.84338573
13ERN11.83445434
14STK101.80749994
15SMG11.71595653
16IRAK41.70874413
17AKT31.69668383
18ICK1.67339168
19FES1.61591375
20BLK1.60420709
21GRK61.58020972
22CDK41.55345109
23EPHB11.49092818
24SIK31.47654632
25ALK1.44330401
26JAK31.41423081
27MTOR1.35667655
28PTK61.34728358
29CAMK1G1.33352119
30RIPK11.32055446
31CDK61.26194289
32MAP3K71.26120266
33CAMK1D1.23017641
34TYRO31.20545417
35DMPK1.19770356
36TAOK11.16902801
37NLK1.14288905
38TXK1.13003767
39MARK21.08814769
40CSF1R1.08674214
41LATS11.08662193
42PDGFRA1.06895650
43IKBKE1.06741716
44SIK11.05676110
45BTK1.04433121
46HIPK21.03593808
47MAP3K141.02297364
48MELK1.01634092
49PRKD21.01191073
50CDK71.00823853
51SGK20.98590604
52CDK90.98442758
53MAP3K30.97448376
54LRRK20.94253237
55TTN0.91669242
56CHEK10.91242724
57RPS6KA40.91125150
58BMX0.90802230
59YES10.87963876
60KSR20.87851466
61ATR0.87763643
62CAMKK10.85169682
63STK380.84623628
64TAOK30.83453084
65TEC0.82640872
66MAP3K80.82448940
67TTK0.81728842
68RPS6KB20.80923792
69FGFR30.80701179
70IRAK10.79675214
71FLT30.79312153
72ZAP700.79196564
73MAP3K60.78348352
74PIM10.78015803
75CDK20.77784852
76CSK0.77123944
77MAP3K10.75423909
78PASK0.74611940
79STK40.74539726
80PDK10.74362452
81MAPK70.73872951
82PDGFRB0.73431010
83LYN0.72702814
84CHEK20.72146257
85TYK20.71942159
86SCYL20.70636791
87CHUK0.70471884
88ATM0.70225795
89STK30.69759879
90ITK0.69717442
91PRKD30.67591632
92PRKCH0.67466760
93HCK0.67101786
94CLK10.66776255
95JAK10.66750446
96TBK10.66223736
97MARK30.65903047
98SGK30.65755167
99IRAK20.62186178
100CDC42BPA0.61493918
101MAPK120.61286886
102WNK10.60375819
103PDPK10.58602847
104SGK2230.58356347
105SGK4940.58356347
106SYK0.56230191
107IKBKB0.56009884
108FRK0.55643248
109CAMK40.53955113
110FGR0.53784924
111MAP2K20.53365418
112PAK40.52491052
113JAK20.52174138
114FGFR40.51933294
115RPS6KC10.50845976
116RPS6KL10.50845976
117PAK20.50739507
118LCK0.50230468
119EPHA30.49411990
120TGFBR20.49269377
121* MAPK140.48785550
122MAPK10.47837584
123MATK0.47630411
124MAP3K130.47452756
125STK110.46526133
126TGFBR10.46519685
127RPS6KA10.46347786
128KIT0.46101022
129PRKAA20.45950016
130TNK20.45909740
131* CDK10.45384420
132RET0.45262429
133MKNK20.45157263
134RPS6KA60.44319226
135MAPK110.42431311
136AKT10.41924475
137PTK20.41258197
138RPS6KA20.39589885
139* GSK3B0.38871361
140MAP2K30.38699636
141MAPK100.38432065

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053401.99668557
2B cell receptor signaling pathway_Homo sapiens_hsa046621.92593678
3Lysine degradation_Homo sapiens_hsa003101.91949768
4mRNA surveillance pathway_Homo sapiens_hsa030151.91403492
5Chronic myeloid leukemia_Homo sapiens_hsa052201.87721733
6mTOR signaling pathway_Homo sapiens_hsa041501.72996939
7Notch signaling pathway_Homo sapiens_hsa043301.65596990
8Non-small cell lung cancer_Homo sapiens_hsa052231.57519710
9Acute myeloid leukemia_Homo sapiens_hsa052211.54083193
10Cell cycle_Homo sapiens_hsa041101.53279323
11MicroRNAs in cancer_Homo sapiens_hsa052061.46095864
12Colorectal cancer_Homo sapiens_hsa052101.45401064
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39641957
14Pancreatic cancer_Homo sapiens_hsa052121.39422754
15T cell receptor signaling pathway_Homo sapiens_hsa046601.37946938
16Spliceosome_Homo sapiens_hsa030401.36894216
17RNA transport_Homo sapiens_hsa030131.36885049
18Adherens junction_Homo sapiens_hsa045201.34433084
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34097491
20Mismatch repair_Homo sapiens_hsa034301.33336568
21DNA replication_Homo sapiens_hsa030301.32599757
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32191321
23Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32107155
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30016221
25Small cell lung cancer_Homo sapiens_hsa052221.29287958
26Base excision repair_Homo sapiens_hsa034101.26533424
27Endometrial cancer_Homo sapiens_hsa052131.25725967
28Herpes simplex infection_Homo sapiens_hsa051681.24647544
29HTLV-I infection_Homo sapiens_hsa051661.23647937
30Graft-versus-host disease_Homo sapiens_hsa053321.23354768
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22641988
32Hepatitis C_Homo sapiens_hsa051601.20376086
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.17844602
34Allograft rejection_Homo sapiens_hsa053301.16513367
35Antigen processing and presentation_Homo sapiens_hsa046121.16373596
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15100998
37Autoimmune thyroid disease_Homo sapiens_hsa053201.14828541
38Tuberculosis_Homo sapiens_hsa051521.14355022
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13849043
40Staphylococcus aureus infection_Homo sapiens_hsa051501.10090144
41Osteoclast differentiation_Homo sapiens_hsa043801.09714740
42Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05863741
43Proteoglycans in cancer_Homo sapiens_hsa052051.05394437
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05182788
45Glioma_Homo sapiens_hsa052141.05061432
46Hepatitis B_Homo sapiens_hsa051611.04338256
47VEGF signaling pathway_Homo sapiens_hsa043701.03779516
48Prostate cancer_Homo sapiens_hsa052151.03198427
49Dorso-ventral axis formation_Homo sapiens_hsa043201.03189693
50Other glycan degradation_Homo sapiens_hsa005111.00950715
51Viral myocarditis_Homo sapiens_hsa054161.00577038
52Measles_Homo sapiens_hsa051621.00026029
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99174533
54Viral carcinogenesis_Homo sapiens_hsa052030.98891918
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98846053
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97932284
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97442459
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.97441348
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95289990
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.95111041
61Platelet activation_Homo sapiens_hsa046110.94800132
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94647632
63Prolactin signaling pathway_Homo sapiens_hsa049170.93115218
64Insulin resistance_Homo sapiens_hsa049310.92154123
65Thyroid cancer_Homo sapiens_hsa052160.91746726
66p53 signaling pathway_Homo sapiens_hsa041150.89376994
67Basal cell carcinoma_Homo sapiens_hsa052170.88839987
68GnRH signaling pathway_Homo sapiens_hsa049120.88471473
69Toxoplasmosis_Homo sapiens_hsa051450.87343071
70Leishmaniasis_Homo sapiens_hsa051400.87108966
71FoxO signaling pathway_Homo sapiens_hsa040680.86676108
72Type II diabetes mellitus_Homo sapiens_hsa049300.86219502
73Pathways in cancer_Homo sapiens_hsa052000.85956348
74RNA degradation_Homo sapiens_hsa030180.85376927
75Chemokine signaling pathway_Homo sapiens_hsa040620.85218964
76Renal cell carcinoma_Homo sapiens_hsa052110.84614070
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.84513650
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.83033247
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82301336
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82152685
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81022832
82Focal adhesion_Homo sapiens_hsa045100.81017433
83Wnt signaling pathway_Homo sapiens_hsa043100.80449433
84One carbon pool by folate_Homo sapiens_hsa006700.79932640
85Hippo signaling pathway_Homo sapiens_hsa043900.79741864
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78847703
87Estrogen signaling pathway_Homo sapiens_hsa049150.77878223
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77595974
89Oocyte meiosis_Homo sapiens_hsa041140.77441721
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.77164962
91Influenza A_Homo sapiens_hsa051640.76718100
92MAPK signaling pathway_Homo sapiens_hsa040100.76576436
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76431483
94Shigellosis_Homo sapiens_hsa051310.76329418
95Type I diabetes mellitus_Homo sapiens_hsa049400.74742260
96ErbB signaling pathway_Homo sapiens_hsa040120.73975615
97TGF-beta signaling pathway_Homo sapiens_hsa043500.71598212
98Epstein-Barr virus infection_Homo sapiens_hsa051690.71231569
99Rap1 signaling pathway_Homo sapiens_hsa040150.70990926
100AMPK signaling pathway_Homo sapiens_hsa041520.70330533
101Hematopoietic cell lineage_Homo sapiens_hsa046400.70185629
102Bladder cancer_Homo sapiens_hsa052190.70175000
103Choline metabolism in cancer_Homo sapiens_hsa052310.68796568
104Malaria_Homo sapiens_hsa051440.68389468
105Apoptosis_Homo sapiens_hsa042100.67726022
106Non-homologous end-joining_Homo sapiens_hsa034500.67309780
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.66922100
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66543157
109Endocytosis_Homo sapiens_hsa041440.66402062
110Long-term potentiation_Homo sapiens_hsa047200.66051998
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.66019987
112Fanconi anemia pathway_Homo sapiens_hsa034600.64583049
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.63292461
114Inositol phosphate metabolism_Homo sapiens_hsa005620.63178653
115Insulin signaling pathway_Homo sapiens_hsa049100.62997510
116TNF signaling pathway_Homo sapiens_hsa046680.62832867
117HIF-1 signaling pathway_Homo sapiens_hsa040660.61145241
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.60076512
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59784761
120Hedgehog signaling pathway_Homo sapiens_hsa043400.59226135
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56954183
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54518648
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53663670
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52707862
125Cholinergic synapse_Homo sapiens_hsa047250.49598389
126Ras signaling pathway_Homo sapiens_hsa040140.46408136
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46336785

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »