PHF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.37649919
2nuclear pore organization (GO:0006999)5.33716789
3DNA unwinding involved in DNA replication (GO:0006268)4.91060264
4protein localization to chromosome, centromeric region (GO:0071459)4.60943276
5mitotic sister chromatid cohesion (GO:0007064)4.51981818
6folic acid-containing compound biosynthetic process (GO:0009396)4.48244763
7histone H3-K9 demethylation (GO:0033169)4.46413925
8interkinetic nuclear migration (GO:0022027)4.45064000
9regulation of translational fidelity (GO:0006450)4.30892288
10protein localization to kinetochore (GO:0034501)4.24980023
11mitotic nuclear envelope disassembly (GO:0007077)4.07700147
12regulation of histone H3-K27 methylation (GO:0061085)4.07069273
13regulation of RNA export from nucleus (GO:0046831)4.03661465
14peptidyl-lysine dimethylation (GO:0018027)4.01311450
15nuclear envelope disassembly (GO:0051081)3.99327619
16membrane disassembly (GO:0030397)3.99327619
17pre-miRNA processing (GO:0031054)3.86910297
18heterochromatin organization (GO:0070828)3.84411051
19glucocorticoid receptor signaling pathway (GO:0042921)3.80315554
20mitotic chromosome condensation (GO:0007076)3.78836059
21sister chromatid cohesion (GO:0007062)3.69286900
22pore complex assembly (GO:0046931)3.68890647
23DNA synthesis involved in DNA repair (GO:0000731)3.67120636
24regulation of histone H3-K9 methylation (GO:0051570)3.53656091
25sister chromatid segregation (GO:0000819)3.52958105
26DNA duplex unwinding (GO:0032508)3.52149710
27DNA geometric change (GO:0032392)3.50523477
28negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.46505915
29negative regulation of histone methylation (GO:0031061)3.46153813
30histone H3-K36 demethylation (GO:0070544)3.45190241
31embryonic retina morphogenesis in camera-type eye (GO:0060059)3.44305857
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.43281364
33synapsis (GO:0007129)3.39159548
34protein localization to chromosome (GO:0034502)3.39077300
35regulation of translational termination (GO:0006449)3.34072236
36positive regulation of cell cycle checkpoint (GO:1901978)3.33008826
37negative regulation of DNA repair (GO:0045738)3.31977782
38corticosteroid receptor signaling pathway (GO:0031958)3.31818686
39regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.31264135
40positive regulation of chromosome segregation (GO:0051984)3.29946529
41regulation of nucleobase-containing compound transport (GO:0032239)3.27053545
42nuclear envelope organization (GO:0006998)3.23929763
43chromatin assembly (GO:0031497)3.23886181
44DNA replication initiation (GO:0006270)3.23538902
45regulation of DNA endoreduplication (GO:0032875)3.22641088
46hippo signaling (GO:0035329)3.22555712
47RNA stabilization (GO:0043489)3.19141573
48mRNA stabilization (GO:0048255)3.19141573
49negative regulation of RNA splicing (GO:0033119)3.15645207
50monoubiquitinated protein deubiquitination (GO:0035520)3.14052207
51kinetochore organization (GO:0051383)3.12049658
52mitotic sister chromatid segregation (GO:0000070)3.10489491
53nucleus localization (GO:0051647)3.10198127
54cytoplasmic mRNA processing body assembly (GO:0033962)3.08396350
55translesion synthesis (GO:0019985)3.06967055
56spliceosomal tri-snRNP complex assembly (GO:0000244)3.05748100
57poly(A)+ mRNA export from nucleus (GO:0016973)3.01826103
58mitotic G1 DNA damage checkpoint (GO:0031571)3.00327562
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98969994
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98969994
61positive regulation of mitotic sister chromatid separation (GO:1901970)2.98969994
62gene silencing by RNA (GO:0031047)2.95045383
63regulation of sister chromatid cohesion (GO:0007063)2.92486821
64histone lysine demethylation (GO:0070076)2.92378039
65DNA replication-dependent nucleosome assembly (GO:0006335)2.91769214
66DNA replication-dependent nucleosome organization (GO:0034723)2.91769214
67definitive hemopoiesis (GO:0060216)2.91361632
68IMP biosynthetic process (GO:0006188)2.88913133
69negative regulation of mRNA metabolic process (GO:1903312)2.88486878
70chromosome organization involved in meiosis (GO:0070192)2.88466049
71IMP metabolic process (GO:0046040)2.88068561
72negative regulation of potassium ion transmembrane transport (GO:1901380)2.87579736
73DNA conformation change (GO:0071103)2.87310821
74chromatin assembly or disassembly (GO:0006333)2.84522161
75chromosome condensation (GO:0030261)2.82725653
76peptidyl-arginine omega-N-methylation (GO:0035247)2.82400500
77negative regulation of mRNA processing (GO:0050686)2.79583173
78peptidyl-arginine methylation (GO:0018216)2.78921174
79peptidyl-arginine N-methylation (GO:0035246)2.78921174
80NLS-bearing protein import into nucleus (GO:0006607)2.78008232
813-UTR-mediated mRNA stabilization (GO:0070935)2.77204283
82paraxial mesoderm development (GO:0048339)2.76886188
83response to epidermal growth factor (GO:0070849)2.74914401
84regulation of NFAT protein import into nucleus (GO:0051532)2.74307823
85histone demethylation (GO:0016577)2.74207679
86regulation of mRNA stability (GO:0043488)2.74064181
87response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.70844173
88regulation of DNA damage checkpoint (GO:2000001)2.70247948
89CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.70046520
90positive regulation of dendritic spine morphogenesis (GO:0061003)2.68404593
91histone exchange (GO:0043486)2.68127998
92cellular response to epidermal growth factor stimulus (GO:0071364)2.67809631
93regulation of chromatin binding (GO:0035561)2.67303152
94chaperone-mediated protein complex assembly (GO:0051131)2.66329301
95regulation of centriole replication (GO:0046599)2.65272055
96regulation of spindle organization (GO:0090224)2.63833364
97myofibril assembly (GO:0030239)2.61040838
98regulation of histone H3-K4 methylation (GO:0051569)2.60899692
99very-low-density lipoprotein particle assembly (GO:0034379)2.60325021
100dorsal/ventral axis specification (GO:0009950)2.60065583
101histone deubiquitination (GO:0016578)2.59985839
102formation of translation preinitiation complex (GO:0001731)2.59192207
103cardiac myofibril assembly (GO:0055003)2.57882211
104embryonic viscerocranium morphogenesis (GO:0048703)2.56593920
105protein export from nucleus (GO:0006611)2.56530317
106meiotic chromosome segregation (GO:0045132)2.56219188
107G1 DNA damage checkpoint (GO:0044783)2.55043597
108protoporphyrinogen IX metabolic process (GO:0046501)2.54877788
109plasma lipoprotein particle assembly (GO:0034377)2.54126497
110negative regulation of histone modification (GO:0031057)2.53031507
111maturation of SSU-rRNA (GO:0030490)2.52543337
112maternal placenta development (GO:0001893)2.52538488
113gene silencing (GO:0016458)2.52421753
114histone H4-K16 acetylation (GO:0043984)2.52282921
115negative regulation of erythrocyte differentiation (GO:0045647)2.52223696
116translational termination (GO:0006415)2.51535599
117DNA packaging (GO:0006323)2.50799416
118protein-lipid complex assembly (GO:0065005)2.50767907
119alternative mRNA splicing, via spliceosome (GO:0000380)2.50592342
120regulation of RNA stability (GO:0043487)2.49052958
121ATP-dependent chromatin remodeling (GO:0043044)2.48613156
122dosage compensation (GO:0007549)2.48393799
123nucleus organization (GO:0006997)2.48338129
124DNA topological change (GO:0006265)2.48288554
125DNA strand elongation involved in DNA replication (GO:0006271)2.48197366
126RNA polyadenylation (GO:0043631)2.47582988
127hematopoietic stem cell differentiation (GO:0060218)2.46810849
128viral transcription (GO:0019083)2.46681626
129negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.46284261
130regulation of mitotic spindle organization (GO:0060236)2.45131278
131regulation of histone methylation (GO:0031060)2.44587410
132coronary vasculature morphogenesis (GO:0060977)2.44292336
133positive regulation of histone deacetylation (GO:0031065)2.44270879
134regulation of chromosome segregation (GO:0051983)2.43760279
135V(D)J recombination (GO:0033151)2.43566947
136nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.43458584
137establishment of mitotic spindle localization (GO:0040001)2.43370255
138protoporphyrinogen IX biosynthetic process (GO:0006782)2.43227635
139protein dealkylation (GO:0008214)2.42845808
140protein demethylation (GO:0006482)2.42845808
141mRNA transport (GO:0051028)2.42607385
142embryonic camera-type eye morphogenesis (GO:0048596)2.42123460
143histone H3 deacetylation (GO:0070932)2.41313390
144positive regulation of translational initiation (GO:0045948)2.40921082
145regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.39478130
146male meiosis I (GO:0007141)2.38394103
147regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.38252156
148resolution of meiotic recombination intermediates (GO:0000712)2.37546665
149mRNA splice site selection (GO:0006376)2.36002090
150nucleosome disassembly (GO:0006337)2.35765790
151protein-DNA complex disassembly (GO:0032986)2.35765790
152negative regulation of gene expression, epigenetic (GO:0045814)2.33833409
153mRNA export from nucleus (GO:0006406)2.32457675
154cellular hyperosmotic response (GO:0071474)2.32030458
155RNA export from nucleus (GO:0006405)2.31223603
156embryonic foregut morphogenesis (GO:0048617)2.24901640
157histone H4 acetylation (GO:0043967)2.24367927
158body morphogenesis (GO:0010171)2.23607788
159positive regulation of histone methylation (GO:0031062)2.23139356
160creatine metabolic process (GO:0006600)2.21442331
161synaptonemal complex assembly (GO:0007130)2.19034358
162regulation of non-canonical Wnt signaling pathway (GO:2000050)2.18449789

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.42847544
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.45004921
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.53016121
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.75349390
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71390149
6MYC_22102868_ChIP-Seq_BL_Human3.43587288
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.40369354
8* MYC_18555785_ChIP-Seq_MESCs_Mouse3.28679836
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.14845476
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.98859476
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52108476
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.51867385
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.50512989
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44328412
15AR_21909140_ChIP-Seq_LNCAP_Human2.26053040
16AR_21572438_ChIP-Seq_LNCaP_Human2.22018311
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.20061111
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.17352602
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14153904
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03155761
21FUS_26573619_Chip-Seq_HEK293_Human1.95628209
22TCF7_22412390_ChIP-Seq_EML_Mouse1.88676276
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86069454
24IGF1R_20145208_ChIP-Seq_DFB_Human1.83064731
25* VDR_21846776_ChIP-Seq_THP-1_Human1.82542952
26XRN2_22483619_ChIP-Seq_HELA_Human1.81192550
27ZNF263_19887448_ChIP-Seq_K562_Human1.81114890
28KDM2B_26808549_Chip-Seq_DND41_Human1.77386046
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76377688
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73662012
31CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.71134173
32* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69929866
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66989838
34TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.66337450
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65821016
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65096600
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.63353597
38CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.63322876
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60830486
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59049792
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58953326
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56157286
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.55038773
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53903414
45SALL4_18804426_ChIP-ChIP_XEN_Mouse1.52871274
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52437542
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.48009544
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47499400
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46455441
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45854023
51ATF3_27146783_Chip-Seq_COLON_Human1.43004794
52KDM5A_27292631_Chip-Seq_BREAST_Human1.39834281
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.39605246
54DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39104645
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38716363
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38447127
57CHD1_26751641_Chip-Seq_LNCaP_Human1.37603913
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37069273
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36587863
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36324984
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36324984
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36324984
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36245006
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35978381
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34487243
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29959632
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29173553
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28780449
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27769227
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26223049
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25994727
72TTF2_22483619_ChIP-Seq_HELA_Human1.25307238
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24213915
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24024410
75FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.23327470
76NANOG_21062744_ChIP-ChIP_HESCs_Human1.23314973
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.23090293
78* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22698648
79CIITA_25753668_ChIP-Seq_RAJI_Human1.22152232
80* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21940205
81RNF2_27304074_Chip-Seq_NSC_Mouse1.20652062
82CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20257222
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19780167
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19420197
85UTX_26944678_Chip-Seq_JUKART_Human1.19389092
86EWS_26573619_Chip-Seq_HEK293_Human1.18817531
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.17141687
88MAF_26560356_Chip-Seq_TH1_Human1.16796474
89PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16217117
90* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14407439
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14305927
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.14263702
93NCOR1_26117541_ChIP-Seq_K562_Human1.14140644
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13718031
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12514591
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12051694
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11656741
98CLOCK_20551151_ChIP-Seq_293T_Human1.09828418
99TFEB_21752829_ChIP-Seq_HELA_Human1.09507368
100CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09337430
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08832514
102MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07903460
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07891184
104ZNF274_21170338_ChIP-Seq_K562_Hela1.07817042
105RING1B_27294783_Chip-Seq_NPCs_Mouse1.06495290
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05665232
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03083518
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03083518
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02813957
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00920249
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00362716
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98723428
113HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98721333
114TCF4_18268006_ChIP-ChIP_LS174T_Human0.97666482
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96934795
116* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94515232
117BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94066115
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93020889
119POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92098203
120SCL_19346495_ChIP-Seq_HPC-7_Human0.91881516
121TP53_22127205_ChIP-Seq_IMR90_Human0.91413043
122RUNX1_26923725_Chip-Seq_HPCs_Mouse0.90236468
123STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90218668
124EP300_21415370_ChIP-Seq_HL-1_Mouse0.89991122
125FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.89922129
126YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89655360
127ELK1_19687146_ChIP-ChIP_HELA_Human0.89182017
128* VDR_24763502_ChIP-Seq_THP-1_Human0.89023626
129SOX9_26525672_Chip-Seq_HEART_Mouse0.87733234
130* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87077075
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86744783
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84591838
133* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84545066
134FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84524958
135NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84134863
136PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83933278
137RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83387834
138TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83206139
139CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81999799
140TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81867981
141GATA1_22025678_ChIP-Seq_K562_Human0.81098812
142STAT3_23295773_ChIP-Seq_U87_Human0.80440952
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80093983
144CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79392612
145TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.79189154
146FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78983887
147LXR_22158963_ChIP-Seq_LIVER_Mouse0.78279185
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.76502174
149SOX2_21211035_ChIP-Seq_LN229_Gbm0.75602874
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74938789
151LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74822458
152TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.74281931
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74072123
154TBX3_20139965_ChIP-Seq_MESCs_Mouse0.73582143
155TBX3_20139965_ChIP-Seq_ESCs_Mouse0.73516882
156ZNF217_24962896_ChIP-Seq_MCF-7_Human0.73429478
157SMAD3_21741376_ChIP-Seq_EPCs_Human0.73333794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia3.97353381
2MP0003890_abnormal_embryonic-extraembry3.52294002
3MP0003123_paternal_imprinting3.28466587
4MP0010352_gastrointestinal_tract_polyps3.16919056
5MP0005076_abnormal_cell_differentiation3.06199123
6MP0003705_abnormal_hypodermis_morpholog3.05211064
7MP0000569_abnormal_digit_pigmentation2.84931427
8MP0006054_spinal_hemorrhage2.62317414
9MP0003111_abnormal_nucleus_morphology2.51034097
10MP0010094_abnormal_chromosome_stability2.49348370
11MP0004233_abnormal_muscle_weight2.35656169
12MP0010307_abnormal_tumor_latency2.33788177
13MP0004957_abnormal_blastocyst_morpholog2.26635877
14MP0000566_synostosis2.21460507
15MP0005409_darkened_coat_color2.17501356
16MP0003943_abnormal_hepatobiliary_system2.15696422
17MP0008438_abnormal_cutaneous_collagen2.15201400
18MP0003077_abnormal_cell_cycle2.11002713
19MP0003121_genomic_imprinting2.06487554
20MP0002396_abnormal_hematopoietic_system1.92715790
21MP0004197_abnormal_fetal_growth/weight/1.91935699
22MP0008877_abnormal_DNA_methylation1.90901926
23MP0000733_abnormal_muscle_development1.87975162
24MP0002249_abnormal_larynx_morphology1.86397765
25MP0004185_abnormal_adipocyte_glucose1.81686973
26MP0004036_abnormal_muscle_relaxation1.81255590
27MP0004808_abnormal_hematopoietic_stem1.80854127
28MP0000537_abnormal_urethra_morphology1.79080957
29MP0010368_abnormal_lymphatic_system1.78342201
30MP0003122_maternal_imprinting1.78005590
31MP0003646_muscle_fatigue1.76020896
32MP0001730_embryonic_growth_arrest1.75207097
33MP0005623_abnormal_meninges_morphology1.73351366
34MP0003567_abnormal_fetal_cardiomyocyte1.71998099
35MP0000350_abnormal_cell_proliferation1.69480418
36MP0008057_abnormal_DNA_replication1.65157640
37MP0001849_ear_inflammation1.62361725
38MP0005397_hematopoietic_system_phenotyp1.61629133
39MP0001545_abnormal_hematopoietic_system1.61629133
40MP0003656_abnormal_erythrocyte_physiolo1.57766807
41MP0006138_congestive_heart_failure1.57100437
42MP0002084_abnormal_developmental_patter1.53521704
43MP0001697_abnormal_embryo_size1.48902875
44MP0002877_abnormal_melanocyte_morpholog1.48287368
45MP0000751_myopathy1.46913196
46MP0002086_abnormal_extraembryonic_tissu1.44658231
47MP0003984_embryonic_growth_retardation1.44399223
48MP0001672_abnormal_embryogenesis/_devel1.41748026
49MP0005380_embryogenesis_phenotype1.41748026
50MP0009053_abnormal_anal_canal1.41733501
51MP0002088_abnormal_embryonic_growth/wei1.40745808
52MP0009278_abnormal_bone_marrow1.40488461
53MP0001348_abnormal_lacrimal_gland1.39354146
54MP0001661_extended_life_span1.37288633
55MP0000428_abnormal_craniofacial_morphol1.35537989
56MP0003566_abnormal_cell_adhesion1.35295451
57MP0002085_abnormal_embryonic_tissue1.34806338
58MP0010234_abnormal_vibrissa_follicle1.33938537
59MP0002080_prenatal_lethality1.33497045
60MP0001929_abnormal_gametogenesis1.32213188
61MP0001346_abnormal_lacrimal_gland1.29884829
62MP0004087_abnormal_muscle_fiber1.28604143
63MP0004084_abnormal_cardiac_muscle1.28123463
64MP0009672_abnormal_birth_weight1.27663805
65MP0003698_abnormal_male_reproductive1.24619935
66MP0003300_gastrointestinal_ulcer1.23822718
67MP0000678_abnormal_parathyroid_gland1.23425585
68MP0003693_abnormal_embryo_hatching1.22773064
69MP0010630_abnormal_cardiac_muscle1.21978843
70MP0004145_abnormal_muscle_electrophysio1.21493037
71MP0005503_abnormal_tendon_morphology1.20228939
72MP0002210_abnormal_sex_determination1.19906738
73MP0005187_abnormal_penis_morphology1.19185947
74MP0009703_decreased_birth_body1.19154229
75MP0003787_abnormal_imprinting1.18345589
76MP0002971_abnormal_brown_adipose1.17497629
77MP0003385_abnormal_body_wall1.17157574
78MP0002127_abnormal_cardiovascular_syste1.15537371
79MP0001293_anophthalmia1.14934977
80MP0001270_distended_abdomen1.11746689
81MP0009250_abnormal_appendicular_skeleto1.11605547
82MP0002269_muscular_atrophy1.10657981
83MP0001286_abnormal_eye_development1.09984915
84MP0003115_abnormal_respiratory_system1.09280067
85MP0000490_abnormal_crypts_of1.07362770
86MP0002932_abnormal_joint_morphology1.06430448
87MP0002160_abnormal_reproductive_system1.04938775
88MP0005379_endocrine/exocrine_gland_phen1.04498699
89MP0005451_abnormal_body_composition1.04419725
90MP0008007_abnormal_cellular_replicative1.04195730
91MP0000747_muscle_weakness1.04035214
92MP0003119_abnormal_digestive_system1.04032256
93MP0001145_abnormal_male_reproductive1.03834905
94MP0002697_abnormal_eye_size1.03672683
95MP0004147_increased_porphyrin_level1.02255133
96MP0003935_abnormal_craniofacial_develop1.01237897
97MP0002925_abnormal_cardiovascular_devel1.00400818
98MP0002282_abnormal_trachea_morphology0.99618810
99MP0002132_abnormal_respiratory_system0.99312167
100MP0000534_abnormal_ureter_morphology0.99190815
101MP0010030_abnormal_orbit_morphology0.99040731
102MP0001915_intracranial_hemorrhage0.96942880
103MP0009697_abnormal_copulation0.96785822
104MP0006292_abnormal_olfactory_placode0.96273543
105MP0005275_abnormal_skin_tensile0.95726199
106MP0002106_abnormal_muscle_physiology0.94925032
107MP0003091_abnormal_cell_migration0.94788052
108MP0000266_abnormal_heart_morphology0.93452352
109MP0002089_abnormal_postnatal_growth/wei0.92578441
110MP0003861_abnormal_nervous_system0.90676596
111MP0000313_abnormal_cell_death0.90511841
112MP0000653_abnormal_sex_gland0.90190908
113MP0002116_abnormal_craniofacial_bone0.88534358
114MP0000759_abnormal_skeletal_muscle0.87203234
115MP0008770_decreased_survivor_rate0.86746829
116MP0000003_abnormal_adipose_tissue0.86257225
117MP0002822_catalepsy0.86199948
118MP0003937_abnormal_limbs/digits/tail_de0.86034614
119MP0004215_abnormal_myocardial_fiber0.85758457
120MP0005330_cardiomyopathy0.85586228
121MP0002938_white_spotting0.84575188
122MP0005023_abnormal_wound_healing0.84563463
123MP0003283_abnormal_digestive_organ0.83289509
124MP0005670_abnormal_white_adipose0.83162154
125MP0005369_muscle_phenotype0.82931277
126MP0005666_abnormal_adipose_tissue0.82842390
127MP0001879_abnormal_lymphatic_vessel0.82456886
128MP0002092_abnormal_eye_morphology0.81558948
129MP0001188_hyperpigmentation0.81108653
130MP0003221_abnormal_cardiomyocyte_apopto0.80748543
131MP0005375_adipose_tissue_phenotype0.80168768
132MP0002108_abnormal_muscle_morphology0.79341190
133MP0008775_abnormal_heart_ventricle0.79318605
134MP0002114_abnormal_axial_skeleton0.79119928
135MP0003942_abnormal_urinary_system0.78846731
136MP0002166_altered_tumor_susceptibility0.78502887
137MP0000749_muscle_degeneration0.78372276
138MP0008995_early_reproductive_senescence0.78011360
139MP0003303_peritoneal_inflammation0.76981496
140MP0008961_abnormal_basal_metabolism0.76345872

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the left ventricular outflow tract (HP:0011103)4.04849004
2Subaortic stenosis (HP:0001682)4.04849004
3Abnormality of the heme biosynthetic pathway (HP:0010472)3.93461968
4Absent frontal sinuses (HP:0002688)3.57097371
5Syringomyelia (HP:0003396)3.43306205
6Spinal cord lesions (HP:0100561)3.43306205
7Papillary thyroid carcinoma (HP:0002895)3.17066384
8Broad palm (HP:0001169)3.02590413
9Diastasis recti (HP:0001540)3.01861821
10Exercise-induced myalgia (HP:0003738)2.94477811
11Asymmetry of the thorax (HP:0001555)2.85880339
12Subacute progressive viral hepatitis (HP:0006572)2.79808826
13Short middle phalanx of the 5th finger (HP:0004220)2.78453752
14Deep venous thrombosis (HP:0002625)2.74598566
15Protrusio acetabuli (HP:0003179)2.72391266
16Acanthocytosis (HP:0001927)2.71216885
17Short 4th metacarpal (HP:0010044)2.64793267
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.64793267
19Hyperacusis (HP:0010780)2.63327955
20Nephroblastoma (Wilms tumor) (HP:0002667)2.58229165
21Acute myeloid leukemia (HP:0004808)2.57437861
22Embryonal renal neoplasm (HP:0011794)2.53448275
23Exercise-induced muscle cramps (HP:0003710)2.53166837
24Insomnia (HP:0100785)2.52769159
25Increased nuchal translucency (HP:0010880)2.51634833
26Increased density of long bones (HP:0006392)2.47961942
27Volvulus (HP:0002580)2.47707430
28Chromsome breakage (HP:0040012)2.47486137
29Rectal prolapse (HP:0002035)2.47037494
30Abnormality of cochlea (HP:0000375)2.46921743
31Renal duplication (HP:0000075)2.46687086
32Overlapping toe (HP:0001845)2.44531066
33Macroorchidism (HP:0000053)2.44180501
34Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.43539630
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43184890
36Ulnar deviation of the wrist (HP:0003049)2.42200996
37Type 1 muscle fiber predominance (HP:0003803)2.38394949
38Abnormality of the calcaneus (HP:0008364)2.38305632
39Genu recurvatum (HP:0002816)2.36918011
40Shallow orbits (HP:0000586)2.35669490
41Abnormality of the 4th metacarpal (HP:0010012)2.35523260
42Pelvic girdle muscle weakness (HP:0003749)2.31963731
43Cutaneous melanoma (HP:0012056)2.31531146
44Abnormality of chromosome segregation (HP:0002916)2.28848327
45Abnormality of cells of the erythroid lineage (HP:0012130)2.28374378
46Termporal pattern (HP:0011008)2.27192738
47Insidious onset (HP:0003587)2.27192738
48Truncal obesity (HP:0001956)2.22411935
49Short 5th finger (HP:0009237)2.22361079
50Exostoses (HP:0100777)2.22269602
51Small epiphyses (HP:0010585)2.22266137
52Selective tooth agenesis (HP:0001592)2.22063158
53Abnormality of the astrocytes (HP:0100707)2.20687787
54Astrocytoma (HP:0009592)2.20687787
55Hepatoblastoma (HP:0002884)2.20325295
56Skull defect (HP:0001362)2.17946126
57High pitched voice (HP:0001620)2.16019312
58Ependymoma (HP:0002888)2.13699882
59Abnormality of the lumbar spine (HP:0100712)2.13552563
60Shoulder girdle muscle weakness (HP:0003547)2.13245752
61Abnormal number of erythroid precursors (HP:0012131)2.12369494
62Limited elbow extension (HP:0001377)2.12002746
63Abnormality of the musculature of the pelvis (HP:0001469)2.09944042
64Abnormality of the hip-girdle musculature (HP:0001445)2.09944042
6511 pairs of ribs (HP:0000878)2.09633531
66Muscle fiber inclusion bodies (HP:0100299)2.09630007
67Mesomelia (HP:0003027)2.07342869
68Myopathic facies (HP:0002058)2.07069170
69Slender build (HP:0001533)2.06426643
70Fibrous tissue neoplasm (HP:0012316)2.04335317
71Broad thumb (HP:0011304)2.04315419
72Ankle contracture (HP:0006466)2.03979860
73Bowel diverticulosis (HP:0005222)2.03447822
74Embryonal neoplasm (HP:0002898)2.01575261
75Enlarged penis (HP:0000040)2.01550678
76Cerebral aneurysm (HP:0004944)2.01515478
77Fibroma (HP:0010614)2.00688779
78Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.00092804
79Cystic hygroma (HP:0000476)2.00067727
80Anteriorly placed anus (HP:0001545)1.98464065
81Abnormal ventriculo-arterial connection (HP:0011563)1.98233641
82Transposition of the great arteries (HP:0001669)1.98233641
83Abnormal connection of the cardiac segments (HP:0011545)1.98233641
84Rhizomelia (HP:0008905)1.97820504
85Delayed closure of the anterior fontanelle (HP:0001476)1.96710261
86Pancreatic islet-cell hyperplasia (HP:0004510)1.96522756
87Heterotopia (HP:0002282)1.95413570
88Midline defect of the nose (HP:0004122)1.95049640
89Abnormality of the nasal septum (HP:0000419)1.94162425
90Metaphyseal dysplasia (HP:0100255)1.94056182
91Calcaneovalgus deformity (HP:0001848)1.93859416
92Metaphyseal cupping (HP:0003021)1.93651550
93Facial hemangioma (HP:0000329)1.93597465
94Muscle hypertrophy of the lower extremities (HP:0008968)1.93548745
95Abnormality of the frontal sinuses (HP:0002687)1.92690051
96Cutis marmorata (HP:0000965)1.92389192
97Morphological abnormality of the inner ear (HP:0011390)1.92036729
98Limb-girdle muscle weakness (HP:0003325)1.91868202
99Broad alveolar ridges (HP:0000187)1.90946010
100Thin ribs (HP:0000883)1.90847050
101Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.89443638
102Acute lymphatic leukemia (HP:0006721)1.89178519
103Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88740051
104Aplasia/Hypoplasia of the sternum (HP:0006714)1.87481856
105Abnormality of the pubic bones (HP:0003172)1.87407577
106Distal arthrogryposis (HP:0005684)1.87082858
107Reticulocytosis (HP:0001923)1.87051557
108Sandal gap (HP:0001852)1.87030231
109Calf muscle hypertrophy (HP:0008981)1.86979321
110Nemaline bodies (HP:0003798)1.86533788
111Exotropia (HP:0000577)1.84084923
112Periauricular skin pits (HP:0100277)1.83858932
113Preauricular pit (HP:0004467)1.83858932
114Irregular epiphyses (HP:0010582)1.82153837
115Dilatation of the ascending aorta (HP:0005111)1.81627078
116Hypoplastic ischia (HP:0003175)1.81600914
117Renovascular hypertension (HP:0100817)1.81047128
118Increased connective tissue (HP:0009025)1.80848209
119Sacral dimple (HP:0000960)1.80704724
120Thyroid carcinoma (HP:0002890)1.79690861
1212-3 toe syndactyly (HP:0004691)1.77964462
122Abnormal tarsal ossification (HP:0008369)1.77232859
123Missing ribs (HP:0000921)1.76689288
124Urethral obstruction (HP:0000796)1.76501444
125Cubitus valgus (HP:0002967)1.76431701
126Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76253777
127Abnormality of the fingertips (HP:0001211)1.75671380
128Angiofibromas (HP:0010615)1.75466851
129Adenoma sebaceum (HP:0009720)1.75466851
130Hyperkalemia (HP:0002153)1.75022614
131Anal stenosis (HP:0002025)1.74913992
132Bladder diverticulum (HP:0000015)1.74790502
133Ankyloglossia (HP:0010296)1.73938202
134Rimmed vacuoles (HP:0003805)1.73769729
135Colon cancer (HP:0003003)1.73613521
136Low anterior hairline (HP:0000294)1.73308838
137Deformed tarsal bones (HP:0008119)1.72822097
138Aortic aneurysm (HP:0004942)1.72812455
139Megalencephaly (HP:0001355)1.72760957
140Bicuspid aortic valve (HP:0001647)1.72671085
141Mitral valve prolapse (HP:0001634)1.72599803
142Abnormal foot bone ossification (HP:0010675)1.72510645
143Premature rupture of membranes (HP:0001788)1.72507153
144Obsessive-compulsive behavior (HP:0000722)1.71086734
145Distal upper limb amyotrophy (HP:0007149)1.70951827
146Upper limb amyotrophy (HP:0009129)1.70951827
147Pointed chin (HP:0000307)1.70491958
148Deviation of the hallux (HP:0010051)1.70190308
149Hallux valgus (HP:0001822)1.70038341
150Limb-girdle muscle atrophy (HP:0003797)1.69904673
151Round ear (HP:0100830)1.69626599
152Deviation of the thumb (HP:0009603)1.68638685
153Thickened helices (HP:0000391)1.68267165
154Broad phalanges of the hand (HP:0009768)1.68100467
155Prominent nose (HP:0000448)1.67930904
156Hypobetalipoproteinemia (HP:0003563)1.67323929
157Abnormality of DNA repair (HP:0003254)1.67243300
158Scapular winging (HP:0003691)1.66980984
159Omphalocele (HP:0001539)1.66917338
160Metatarsus adductus (HP:0001840)1.65813751
161Elfin facies (HP:0004428)1.65567743
162Narrow palate (HP:0000189)1.65349874
163Smooth philtrum (HP:0000319)1.65333938
164Vertebral clefting (HP:0008428)1.65214527
165Achilles tendon contracture (HP:0001771)1.64338987
166Lower limb asymmetry (HP:0100559)1.64224215
167Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.63208969
168Oligodactyly (hands) (HP:0001180)1.62817864
169Dysmetric saccades (HP:0000641)1.62708386
170Flat acetabular roof (HP:0003180)1.62066833
171Dislocated radial head (HP:0003083)1.61584412
172Poikilocytosis (HP:0004447)1.61408397
173Intestinal fistula (HP:0100819)1.58868222
174Abnormality of endocrine pancreas physiology (HP:0012093)1.58009632
175Abnormality of the pancreatic islet cells (HP:0006476)1.58009632
176Broad distal phalanx of finger (HP:0009836)1.57410319
177Deep philtrum (HP:0002002)1.57274529
178Abnormality of the wing of the ilium (HP:0011867)1.55645390
179Hypoplastic iliac wings (HP:0002866)1.55205542
180Abnormality of the ischium (HP:0003174)1.54653189
181Abnormality of the aortic arch (HP:0012303)1.54426644
182Abnormality of the distal phalanx of the thumb (HP:0009617)1.52586683
183Abnormality of the radial head (HP:0003995)1.52121430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.22119246
2CDC73.83491236
3TRIB33.55418428
4EEF2K3.50936279
5MAP3K102.91051904
6STK32.66098602
7NEK22.62328330
8NEK12.34964222
9TTN2.26923342
10SCYL22.12815392
11CDK121.98969545
12PRPF4B1.89023110
13LRRK21.72626138
14ALK1.64490082
15STK101.60094472
16TYRO31.59363028
17TTK1.58199740
18FGFR41.55904126
19ICK1.54044340
20CDK61.51760233
21PDGFRA1.50019991
22PTK61.48041462
23SMG11.47626483
24PLK41.46550525
25UHMK11.37029928
26PRKD31.36392326
27PAK21.35725121
28AKT31.34788629
29NEK91.34515138
30MAP3K71.34393728
31DDR21.34289047
32WNK11.33888183
33FLT31.31241435
34PDK41.29772725
35PDK31.29772725
36RPS6KB21.29239444
37CDK41.28378697
38WEE11.23800423
39RIPK11.22528410
40PAK41.18182649
41LATS11.17938470
42LATS21.17744830
43SRPK11.17356760
44MTOR1.17175090
45MAP3K81.14536474
46BMX1.14217514
47EIF2AK31.12978138
48YES11.08979573
49STK241.06222636
50CHEK11.05693706
51CDK31.02318907
52BRD41.01143851
53FGFR10.99199998
54SIK20.96807215
55CLK10.95500805
56SIK10.95221246
57ATR0.93690010
58PLK30.93511225
59PLK20.91627448
60STK38L0.88924746
61ATM0.88511333
62PLK10.87348172
63RET0.86580407
64STK110.86247392
65SGK20.86164954
66TAF10.86129786
67FGFR30.85580432
68MAP3K130.84985834
69MKNK10.83698450
70JAK30.81077887
71STK380.80499769
72MINK10.79765753
73NLK0.78391327
74AURKB0.77618157
75PASK0.75917625
76RPS6KA40.75886512
77CDK20.73979274
78SGK10.73780271
79CAMK40.73612820
80PHKG10.72884111
81PHKG20.72884111
82EIF2AK10.70803949
83MKNK20.70580774
84PRKAA20.68809921
85DMPK0.68530656
86CAMK1G0.68517786
87ILK0.67368369
88MAP2K30.66362750
89CHEK20.65819471
90PDGFRB0.65597176
91STK40.65410915
92TAOK10.65359335
93SGK30.65284826
94BRSK10.64782278
95CDK90.61486045
96PAK10.60563182
97CSNK1E0.59809585
98PRKDC0.59184551
99ACVR1B0.56834483
100EIF2AK20.56167623
101NEK60.56011836
102CAMK1D0.55982542
103CDK10.55920690
104ERBB30.54420686
105FRK0.54386519
106CDK140.53952912
107RPS6KB10.53849388
108PDK10.53376261
109CDK70.53240627
110RPS6KA10.53169384
111GSK3B0.52912529
112BRSK20.48893608
113SGK2230.48706464
114SGK4940.48706464
115* CSNK1D0.48150351
116KSR10.47819230
117CAMKK10.46489991
118DYRK1B0.46104717
119CDK150.45686791
120KSR20.45662597
121PRKAA10.45313504
122AKT20.45022304
123MAPK100.45020984
124MAP3K140.44195351
125PIK3CA0.44101823
126TGFBR10.43381893
127MAPK140.43237707
128CDK11A0.42253644
129NTRK30.41281090
130EGFR0.41023929
131CDK80.40897992
132PNCK0.40026981
133MAP2K60.39369989
134PDPK10.38394078
135MAP3K20.37531397
136PTK2B0.36760423
137CDK180.36332976
138PAK60.36241110
139OBSCN0.36006824
140MELK0.35965678
141AKT10.35613125
142MET0.35457279
143CSNK2A20.35036377
144FGFR20.35016950

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.69820444
2Cell cycle_Homo sapiens_hsa041102.34767621
3One carbon pool by folate_Homo sapiens_hsa006702.34426908
4RNA transport_Homo sapiens_hsa030132.30788069
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89430067
6Spliceosome_Homo sapiens_hsa030401.78042124
7Mismatch repair_Homo sapiens_hsa034301.77985974
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74287490
9mRNA surveillance pathway_Homo sapiens_hsa030151.73993423
10Chronic myeloid leukemia_Homo sapiens_hsa052201.73720809
11Circadian rhythm_Homo sapiens_hsa047101.67532644
12Oocyte meiosis_Homo sapiens_hsa041141.58497481
13mTOR signaling pathway_Homo sapiens_hsa041501.55327951
14Small cell lung cancer_Homo sapiens_hsa052221.48474243
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48208497
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.44077189
17Central carbon metabolism in cancer_Homo sapiens_hsa052301.43925028
18Non-small cell lung cancer_Homo sapiens_hsa052231.42149972
19Proteoglycans in cancer_Homo sapiens_hsa052051.40306378
20MicroRNAs in cancer_Homo sapiens_hsa052061.40201696
21Glioma_Homo sapiens_hsa052141.37974904
22Viral carcinogenesis_Homo sapiens_hsa052031.37377471
23Colorectal cancer_Homo sapiens_hsa052101.35020454
24Fatty acid biosynthesis_Homo sapiens_hsa000611.25820695
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24407370
26Choline metabolism in cancer_Homo sapiens_hsa052311.24131730
27p53 signaling pathway_Homo sapiens_hsa041151.23771244
28RNA degradation_Homo sapiens_hsa030181.23648981
29Thyroid cancer_Homo sapiens_hsa052161.22344418
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20333033
31Endometrial cancer_Homo sapiens_hsa052131.20184113
32Propanoate metabolism_Homo sapiens_hsa006401.18332444
33Focal adhesion_Homo sapiens_hsa045101.18153995
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.17956063
35Hippo signaling pathway_Homo sapiens_hsa043901.16150196
36Bladder cancer_Homo sapiens_hsa052191.12231307
37Renal cell carcinoma_Homo sapiens_hsa052111.11998165
38Glucagon signaling pathway_Homo sapiens_hsa049221.10945869
39HTLV-I infection_Homo sapiens_hsa051661.09716433
40Viral myocarditis_Homo sapiens_hsa054161.07569342
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05863068
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04750854
43Hepatitis B_Homo sapiens_hsa051611.03280068
44Fanconi anemia pathway_Homo sapiens_hsa034601.02833648
45Nucleotide excision repair_Homo sapiens_hsa034201.02387826
46Prostate cancer_Homo sapiens_hsa052151.00307714
47Thyroid hormone synthesis_Homo sapiens_hsa049180.99204727
48Base excision repair_Homo sapiens_hsa034100.98816358
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98785789
50Dorso-ventral axis formation_Homo sapiens_hsa043200.96668055
51Long-term potentiation_Homo sapiens_hsa047200.96546194
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96380540
53Inositol phosphate metabolism_Homo sapiens_hsa005620.96257001
54Estrogen signaling pathway_Homo sapiens_hsa049150.96240473
55Fatty acid metabolism_Homo sapiens_hsa012120.94895086
56Systemic lupus erythematosus_Homo sapiens_hsa053220.94828366
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94171656
58Ribosome_Homo sapiens_hsa030100.90630646
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90529978
60VEGF signaling pathway_Homo sapiens_hsa043700.90322801
61Adherens junction_Homo sapiens_hsa045200.90099304
62Biosynthesis of amino acids_Homo sapiens_hsa012300.90066504
63Acute myeloid leukemia_Homo sapiens_hsa052210.89500202
64Complement and coagulation cascades_Homo sapiens_hsa046100.87939375
65Pancreatic cancer_Homo sapiens_hsa052120.85547405
66HIF-1 signaling pathway_Homo sapiens_hsa040660.84811672
67ECM-receptor interaction_Homo sapiens_hsa045120.84176372
68Prolactin signaling pathway_Homo sapiens_hsa049170.83293545
69Basal cell carcinoma_Homo sapiens_hsa052170.82653967
70Insulin signaling pathway_Homo sapiens_hsa049100.82628665
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81940794
72Alcoholism_Homo sapiens_hsa050340.81926714
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81759879
74Legionellosis_Homo sapiens_hsa051340.81524585
75Dilated cardiomyopathy_Homo sapiens_hsa054140.81445130
76Hedgehog signaling pathway_Homo sapiens_hsa043400.81185955
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80963896
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79071061
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78763803
80Insulin resistance_Homo sapiens_hsa049310.78500239
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77796352
82Fatty acid degradation_Homo sapiens_hsa000710.77635927
83TGF-beta signaling pathway_Homo sapiens_hsa043500.77326081
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77130370
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76548075
86Wnt signaling pathway_Homo sapiens_hsa043100.75609058
87AMPK signaling pathway_Homo sapiens_hsa041520.74424481
88Arginine and proline metabolism_Homo sapiens_hsa003300.72525927
89Tight junction_Homo sapiens_hsa045300.71749955
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71607039
91Long-term depression_Homo sapiens_hsa047300.70775180
92T cell receptor signaling pathway_Homo sapiens_hsa046600.70377427
93Homologous recombination_Homo sapiens_hsa034400.69857210
94Pathways in cancer_Homo sapiens_hsa052000.69846316
95Gap junction_Homo sapiens_hsa045400.68893259
96Amoebiasis_Homo sapiens_hsa051460.68693519
97Platelet activation_Homo sapiens_hsa046110.68419127
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.68106846
99Melanoma_Homo sapiens_hsa052180.67655263
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67438349
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67126502
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67010653
103Pyruvate metabolism_Homo sapiens_hsa006200.66641353
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65994292
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65104624
106Lysine degradation_Homo sapiens_hsa003100.64733108
107Non-homologous end-joining_Homo sapiens_hsa034500.63237969
108Epstein-Barr virus infection_Homo sapiens_hsa051690.61810383
109Antigen processing and presentation_Homo sapiens_hsa046120.61709475
110Notch signaling pathway_Homo sapiens_hsa043300.61175815
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60976269
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60602123
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60143350
114Melanogenesis_Homo sapiens_hsa049160.59766151
115Herpes simplex infection_Homo sapiens_hsa051680.59742582
116Vitamin digestion and absorption_Homo sapiens_hsa049770.59434864
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59049926
118FoxO signaling pathway_Homo sapiens_hsa040680.58537394
119ABC transporters_Homo sapiens_hsa020100.57485929
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57378809
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57219589
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.56904364
123GnRH signaling pathway_Homo sapiens_hsa049120.56409973
124ErbB signaling pathway_Homo sapiens_hsa040120.55288962
125MAPK signaling pathway_Homo sapiens_hsa040100.55100515
126Arginine biosynthesis_Homo sapiens_hsa002200.54328337
127B cell receptor signaling pathway_Homo sapiens_hsa046620.53690031
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.53524979
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53116170
130Protein digestion and absorption_Homo sapiens_hsa049740.52750858
131Apoptosis_Homo sapiens_hsa042100.52614176
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52551348
133Fat digestion and absorption_Homo sapiens_hsa049750.52223691
134Butanoate metabolism_Homo sapiens_hsa006500.52089898
135Ovarian steroidogenesis_Homo sapiens_hsa049130.51797093
136Oxytocin signaling pathway_Homo sapiens_hsa049210.48792515

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