PHBP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.66311729
2cytidine metabolic process (GO:0046087)6.11462623
3cytidine catabolic process (GO:0006216)6.11462623
4cytidine deamination (GO:0009972)6.11462623
5pyrimidine ribonucleoside catabolic process (GO:0046133)5.25105418
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.21899441
7regulation of cellular amino acid metabolic process (GO:0006521)4.63952986
8proteasome assembly (GO:0043248)4.53417484
9DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.44552206
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.43656199
11signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.35322136
12signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.35322136
13signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.35322136
14intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.32603644
15signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.32603644
16regulation of chronic inflammatory response (GO:0002676)4.25837130
17purine deoxyribonucleotide catabolic process (GO:0009155)4.25452750
18positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.13108597
19signal transduction involved in DNA integrity checkpoint (GO:0072401)4.12620346
20signal transduction involved in DNA damage checkpoint (GO:0072422)4.12620346
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.12271214
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.09841232
23signal transduction involved in cell cycle checkpoint (GO:0072395)4.04766439
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.02256294
25negative regulation of ligase activity (GO:0051352)4.02256294
26mucosal-associated lymphoid tissue development (GO:0048537)3.93948455
27Peyers patch development (GO:0048541)3.93948455
28cellular response to interleukin-15 (GO:0071350)3.85102852
29regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.83668669
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.82574139
31antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.81489815
32regulation of regulatory T cell differentiation (GO:0045589)3.81442620
33positive thymic T cell selection (GO:0045059)3.76386595
34regulation of isotype switching to IgG isotypes (GO:0048302)3.72434502
35purine deoxyribonucleotide metabolic process (GO:0009151)3.62742337
36positive T cell selection (GO:0043368)3.59929066
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.54988876
38positive regulation of cell cycle arrest (GO:0071158)3.54528854
39rRNA modification (GO:0000154)3.52141120
40platelet dense granule organization (GO:0060155)3.50394972
41positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.48320935
42pseudouridine synthesis (GO:0001522)3.47626536
43Arp2/3 complex-mediated actin nucleation (GO:0034314)3.47143072
44regulation of T cell mediated cytotoxicity (GO:0001914)3.46352516
45positive regulation of T cell mediated cytotoxicity (GO:0001916)3.41074825
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40987696
47positive regulation of ligase activity (GO:0051351)3.40407076
48positive regulation of defense response to virus by host (GO:0002230)3.35264711
49regulation of leukocyte mediated cytotoxicity (GO:0001910)3.34121672
50positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.33380534
51ATP synthesis coupled proton transport (GO:0015986)3.30641886
52energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30641886
53DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.30081177
54purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.28864629
55antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.26814176
56regulation of cellular amine metabolic process (GO:0033238)3.25094467
57actin nucleation (GO:0045010)3.24001654
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22684496
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22684496
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.14827393
61positive regulation of calcium-mediated signaling (GO:0050850)3.11212689
62response to interferon-beta (GO:0035456)3.07419710
63rRNA methylation (GO:0031167)3.04830098
64iron-sulfur cluster assembly (GO:0016226)3.00937529
65metallo-sulfur cluster assembly (GO:0031163)3.00937529
66pyrimidine nucleoside catabolic process (GO:0046135)3.00391306
67regulation of cell cycle arrest (GO:0071156)2.99964382
68adaptation of signaling pathway (GO:0023058)2.98404138
69lymph node development (GO:0048535)2.97043291
70regulation of immunoglobulin secretion (GO:0051023)2.96669151
71negative regulation of T cell apoptotic process (GO:0070233)2.95278690
72regulation of cell killing (GO:0031341)2.92529850
73mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.90068013
74positive regulation of cell killing (GO:0031343)2.89854794
75negative T cell selection (GO:0043383)2.87417996
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.86979240
77regulation of mitotic spindle checkpoint (GO:1903504)2.86979240
78regulation of ubiquitin-protein transferase activity (GO:0051438)2.86912366
79positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.85659682
80deoxyribonucleotide catabolic process (GO:0009264)2.85180055
81interferon-gamma production (GO:0032609)2.83973064
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83232948
83regulation of ligase activity (GO:0051340)2.83051447
84regulation of gamma-delta T cell differentiation (GO:0045586)2.82631524
85negative regulation of viral genome replication (GO:0045071)2.82276975
86positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81662643
87response to interleukin-15 (GO:0070672)2.81363819
88negative regulation of thymocyte apoptotic process (GO:0070244)2.80687104
89positive regulation of natural killer cell mediated immunity (GO:0002717)2.80591118
90protein neddylation (GO:0045116)2.79334740
91positive regulation of DNA recombination (GO:0045911)2.76018229
92positive regulation of tolerance induction (GO:0002645)2.74856466
93respiratory electron transport chain (GO:0022904)2.74751351
94negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.74663797
95negative regulation of cell cycle G1/S phase transition (GO:1902807)2.74663797
96signal transduction in response to DNA damage (GO:0042770)2.74634575
97negative regulation of protein ubiquitination (GO:0031397)2.74007965
98kynurenine metabolic process (GO:0070189)2.73634056
99deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.70426581
100electron transport chain (GO:0022900)2.69047085

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.39628076
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.30641261
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.11955865
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.95274845
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.85658895
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.76202231
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.26899700
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.21884409
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.17759916
10VDR_23849224_ChIP-Seq_CD4+_Human2.52884189
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51711049
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48374885
13VDR_22108803_ChIP-Seq_LS180_Human2.45112723
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42960191
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.28903976
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04406539
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04204555
18FOXP3_21729870_ChIP-Seq_TREG_Human2.01692822
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00811147
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.00620429
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.94310269
22MYB_26560356_Chip-Seq_TH2_Human1.84641785
23GATA3_26560356_Chip-Seq_TH2_Human1.80376134
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76562015
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.73875984
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.68382836
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68066145
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64882292
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64035346
30ELK1_19687146_ChIP-ChIP_HELA_Human1.57625734
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57344441
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54363216
33MYC_18940864_ChIP-ChIP_HL60_Human1.53646618
34ZNF274_21170338_ChIP-Seq_K562_Hela1.51834478
35GATA3_27048872_Chip-Seq_THYMUS_Human1.50851663
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50220791
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48624288
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46768031
39TP53_22573176_ChIP-Seq_HFKS_Human1.46336001
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44512765
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37935948
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36010028
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.35056151
44RUNX_20019798_ChIP-Seq_JUKART_Human1.34179152
45TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.32216251
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30351015
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30287308
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.29327742
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27108289
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27104660
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25588240
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24694793
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23501577
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.23501577
55PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.23183996
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22062154
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21676395
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21461222
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21359538
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.20618873
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.20034917
62FOXH1_21741376_ChIP-Seq_EPCs_Human1.16581850
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15387538
64IGF1R_20145208_ChIP-Seq_DFB_Human1.15133219
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13336189
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11286296
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11019304
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10521442
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10272414
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08755205
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.08276740
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07661937
73GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06988176
74AR_20517297_ChIP-Seq_VCAP_Human1.05958824
75MYB_26560356_Chip-Seq_TH1_Human1.05946222
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04622401
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03885923
78CBP_20019798_ChIP-Seq_JUKART_Human1.03885923
79GATA6_21074721_ChIP-Seq_CACO-2_Human1.03498789
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02601486
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.02564564
82GABP_19822575_ChIP-Seq_HepG2_Human1.01308553
83DCP1A_22483619_ChIP-Seq_HELA_Human1.00250520
84ERA_21632823_ChIP-Seq_H3396_Human0.99613249
85EWS_26573619_Chip-Seq_HEK293_Human0.99381657
86RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99331087
87TAF2_19829295_ChIP-Seq_ESCs_Human0.98475476
88MYC_19829295_ChIP-Seq_ESCs_Human0.98271516
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98147841
90NCOR_22424771_ChIP-Seq_293T_Human0.97050214
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96902073
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96224602
93HOXB7_26014856_ChIP-Seq_BT474_Human0.95946775
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95939407
95MYC_19030024_ChIP-ChIP_MESCs_Mouse0.94454939
96RBPJ_21746931_ChIP-Seq_IB4_Human0.92851840
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92819987
98HTT_18923047_ChIP-ChIP_STHdh_Human0.90807627
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.90231048
100SPI1_23547873_ChIP-Seq_NB4_Human0.89003527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.40367578
2MP0001835_abnormal_antigen_presentation3.58978496
3MP0000685_abnormal_immune_system3.23542861
4MP0009785_altered_susceptibility_to2.73644717
5MP0005084_abnormal_gallbladder_morpholo2.57265374
6MP0008872_abnormal_physiological_respon2.50109259
7MP0008875_abnormal_xenobiotic_pharmacok2.49293832
8MP0002148_abnormal_hypersensitivity_rea2.41022074
9MP0002138_abnormal_hepatobiliary_system2.35670643
10MP0005000_abnormal_immune_tolerance2.23961556
11MP0009333_abnormal_splenocyte_physiolog2.20386147
12MP0002102_abnormal_ear_morphology2.18337154
13MP0002006_tumorigenesis2.13663354
14MP0001790_abnormal_immune_system2.00542398
15MP0005387_immune_system_phenotype2.00542398
16MP0003763_abnormal_thymus_physiology1.99865098
17MP0001501_abnormal_sleep_pattern1.94400729
18MP0002723_abnormal_immune_serum1.90020706
19MP0001800_abnormal_humoral_immune1.89059572
20MP0000372_irregular_coat_pigmentation1.88338469
21MP0009764_decreased_sensitivity_to1.87179556
22MP0002166_altered_tumor_susceptibility1.86983172
23MP0005025_abnormal_response_to1.84610082
24MP0002420_abnormal_adaptive_immunity1.83089349
25MP0003252_abnormal_bile_duct1.81132636
26MP0001819_abnormal_immune_cell1.79469775
27MP0003724_increased_susceptibility_to1.78087479
28MP0001968_abnormal_touch/_nociception1.71822294
29MP0003646_muscle_fatigue1.71093758
30MP0002837_dystrophic_cardiac_calcinosis1.69120185
31MP0001881_abnormal_mammary_gland1.64420672
32MP0003786_premature_aging1.64078776
33MP0005645_abnormal_hypothalamus_physiol1.63854158
34MP0002452_abnormal_antigen_presenting1.55636158
35MP0008058_abnormal_DNA_repair1.53849137
36MP0002736_abnormal_nociception_after1.53710264
37MP0003866_abnormal_defecation1.52976574
38MP0001873_stomach_inflammation1.45858237
39MP0003195_calcinosis1.44812977
40MP0000716_abnormal_immune_system1.43300914
41MP0002398_abnormal_bone_marrow1.37251523
42MP0006082_CNS_inflammation1.37114915
43MP0006072_abnormal_retinal_apoptosis1.34675630
44MP0005165_increased_susceptibility_to1.33485167
45MP0000689_abnormal_spleen_morphology1.33053281
46MP0010234_abnormal_vibrissa_follicle1.32721348
47MP0003806_abnormal_nucleotide_metabolis1.32103332
48MP0002405_respiratory_system_inflammati1.31961865
49MP0001188_hyperpigmentation1.29402638
50MP0010155_abnormal_intestine_physiology1.28378050
51MP0008877_abnormal_DNA_methylation1.26465357
52MP0003436_decreased_susceptibility_to1.25467453
53MP0003693_abnormal_embryo_hatching1.23799138
54MP0002933_joint_inflammation1.21858747
55MP0000703_abnormal_thymus_morphology1.21412281
56MP0005410_abnormal_fertilization1.21158430
57MP0003075_altered_response_to1.19438922
58MP0001845_abnormal_inflammatory_respons1.18851542
59MP0005646_abnormal_pituitary_gland1.17027978
60MP0002163_abnormal_gland_morphology1.17005033
61MP0002429_abnormal_blood_cell1.16008332
62MP0004381_abnormal_hair_follicle1.13337754
63MP0002419_abnormal_innate_immunity1.13078327
64MP0006036_abnormal_mitochondrial_physio1.12581933
65MP0002722_abnormal_immune_system1.10503625
66MP0001905_abnormal_dopamine_level1.09860546
67MP0006276_abnormal_autonomic_nervous1.09859046
68MP0000604_amyloidosis1.04518774
69MP0003718_maternal_effect1.02173972
70MP0000627_abnormal_mammary_gland1.01900400
71MP0002019_abnormal_tumor_incidence1.01371766
72MP0008469_abnormal_protein_level1.00732760
73MP0006035_abnormal_mitochondrial_morpho0.99654489
74MP0003011_delayed_dark_adaptation0.99209796
75MP0004947_skin_inflammation0.99169242
76MP0002733_abnormal_thermal_nociception0.98701140
77MP0002277_abnormal_respiratory_mucosa0.97857887
78MP0005551_abnormal_eye_electrophysiolog0.96168026
79MP0010386_abnormal_urinary_bladder0.95972132
80MP0001919_abnormal_reproductive_system0.93384991
81MP0005389_reproductive_system_phenotype0.93335205
82MP0001853_heart_inflammation0.93211321
83MP0004147_increased_porphyrin_level0.92702363
84MP0008873_increased_physiological_sensi0.89647803
85MP0003638_abnormal_response/metabolism_0.89449524
86MP0009697_abnormal_copulation0.89125855
87MP0009763_increased_sensitivity_to0.87302963
88MP0000465_gastrointestinal_hemorrhage0.85764280
89MP0001986_abnormal_taste_sensitivity0.85039605
90MP0001533_abnormal_skeleton_physiology0.85025445
91MP0004145_abnormal_muscle_electrophysio0.84946810
92MP0003878_abnormal_ear_physiology0.84734407
93MP0005377_hearing/vestibular/ear_phenot0.84734407
94MP0001984_abnormal_olfaction0.84662493
95MP0002693_abnormal_pancreas_physiology0.84375192
96MP0001348_abnormal_lacrimal_gland0.84003583
97MP0005636_abnormal_mineral_homeostasis0.83688236
98MP0003936_abnormal_reproductive_system0.82587958
99MP0009643_abnormal_urine_homeostasis0.81301966
100MP0003448_altered_tumor_morphology0.80784189

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.25198621
2IgG deficiency (HP:0004315)4.60121894
3Elevated erythrocyte sedimentation rate (HP:0003565)4.36085131
4Increased intramyocellular lipid droplets (HP:0012240)4.10327197
5Severe combined immunodeficiency (HP:0004430)4.05362795
6Hepatocellular necrosis (HP:0001404)3.89590853
7T lymphocytopenia (HP:0005403)3.74229014
8Aplastic anemia (HP:0001915)3.72385102
9Mitochondrial inheritance (HP:0001427)3.68499479
10Increased hepatocellular lipid droplets (HP:0006565)3.66150086
11Abnormality of T cell number (HP:0011839)3.59434284
12Increased muscle lipid content (HP:0009058)3.51993354
13Increased CSF lactate (HP:0002490)3.50724322
14Lipid accumulation in hepatocytes (HP:0006561)3.38709272
15Increased IgM level (HP:0003496)3.37339087
16Hepatic necrosis (HP:0002605)3.34173747
17Abnormal mitochondria in muscle tissue (HP:0008316)3.31099352
18Acute necrotizing encephalopathy (HP:0006965)3.29155168
19Combined immunodeficiency (HP:0005387)3.17077805
20Renal Fanconi syndrome (HP:0001994)3.15504134
21Acute encephalopathy (HP:0006846)2.99121582
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.94069629
23Abnormality of T cells (HP:0002843)2.94019126
24Congenital stationary night blindness (HP:0007642)2.93134381
25Abnormality of eosinophils (HP:0001879)2.86112011
26Spastic paraparesis (HP:0002313)2.84574437
27Type 2 muscle fiber atrophy (HP:0003554)2.83965546
28Hypoproteinemia (HP:0003075)2.75252902
29Retrobulbar optic neuritis (HP:0100654)2.68231724
30Optic neuritis (HP:0100653)2.68231724
31Thyroiditis (HP:0100646)2.67383186
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.66491300
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61175550
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61175550
35Recurrent bronchitis (HP:0002837)2.59589144
36Cerebral edema (HP:0002181)2.58667482
37Eosinophilia (HP:0001880)2.58527559
38Myositis (HP:0100614)2.58381739
39Progressive macrocephaly (HP:0004481)2.58288269
40Pancreatic cysts (HP:0001737)2.55592136
41Autoimmune hemolytic anemia (HP:0001890)2.52053136
42Methylmalonic acidemia (HP:0002912)2.51501889
43Increased serum lactate (HP:0002151)2.49775880
44Exertional dyspnea (HP:0002875)2.49439228
45Oral leukoplakia (HP:0002745)2.45849612
46Muscle fiber atrophy (HP:0100295)2.43654599
47Prostate neoplasm (HP:0100787)2.42037693
48Microretrognathia (HP:0000308)2.33608350
49Cerebral hypomyelination (HP:0006808)2.31133568
50Lactic acidosis (HP:0003128)2.28072360
51Conical tooth (HP:0000698)2.27680404
523-Methylglutaconic aciduria (HP:0003535)2.26964236
53Abnormality of the prostate (HP:0008775)2.25510823
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20677105
55Abnormality of alanine metabolism (HP:0010916)2.20677105
56Hyperalaninemia (HP:0003348)2.20677105
57Orchitis (HP:0100796)2.18808306
58Decreased central vision (HP:0007663)2.17144441
59Short tibia (HP:0005736)2.15976222
60Hypoplasia of the pons (HP:0012110)2.15658863
61Keratoconjunctivitis sicca (HP:0001097)2.15349768
62Sensory axonal neuropathy (HP:0003390)2.15268655
63Respiratory difficulties (HP:0002880)2.14367275
64Severe visual impairment (HP:0001141)2.13099545
65Abnormality of the pons (HP:0007361)2.13093306
66Chronic diarrhea (HP:0002028)2.11779646
67Keratoconjunctivitis (HP:0001096)2.08109823
68Lethargy (HP:0001254)2.08060511
69Abnormality of B cell number (HP:0010975)2.07279894
70Abnormality of T cell physiology (HP:0011840)2.06288902
71Pancytopenia (HP:0001876)2.06113696
72Methylmalonic aciduria (HP:0012120)2.05934499
73Pustule (HP:0200039)2.05622715
74Congenital, generalized hypertrichosis (HP:0004540)2.04979903
75Exercise intolerance (HP:0003546)2.04469061
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03204988
77Abolished electroretinogram (ERG) (HP:0000550)2.02858991
78Recurrent cutaneous fungal infections (HP:0011370)2.01506522
79Chronic mucocutaneous candidiasis (HP:0002728)2.01506522
80Encephalitis (HP:0002383)1.98920061
81Facial diplegia (HP:0001349)1.96836987
82Granulocytopenia (HP:0001913)1.94676629
83Aplasia/hypoplasia of the uterus (HP:0008684)1.94672522
84Abnormality of the renal cortex (HP:0011035)1.94586397
85Abnormal drinking behavior (HP:0030082)1.94450747
86Polydipsia (HP:0001959)1.94450747
87Attenuation of retinal blood vessels (HP:0007843)1.94324934
88Leukocytosis (HP:0001974)1.93940709
89Type I transferrin isoform profile (HP:0003642)1.92995072
90Aplasia/Hypoplasia of the tibia (HP:0005772)1.92036957
91Dicarboxylic aciduria (HP:0003215)1.91689211
92Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91689211
93Gaze-evoked nystagmus (HP:0000640)1.90610257
94Abnormal albumin level (HP:0012116)1.86459419
95Hypoalbuminemia (HP:0003073)1.86459419
96Chronic sinusitis (HP:0011109)1.85676316
97B lymphocytopenia (HP:0010976)1.83328339
98Delayed CNS myelination (HP:0002188)1.82323058
99Polyuria (HP:0000103)1.81453757
100Abnormal rod and cone electroretinograms (HP:0008323)1.80912046

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.70122098
2TXK3.56018191
3TESK23.49646823
4BCKDK3.46524470
5ZAK2.67476573
6EIF2AK32.59396638
7TLK12.51593546
8MAPKAPK32.43130963
9VRK22.40598438
10MAP3K142.32855138
11BUB12.29868728
12MST42.25547650
13SRPK12.23761833
14TAOK32.19176403
15NUAK12.17143061
16MAP3K122.12642888
17ADRBK22.07430168
18TIE11.95413595
19MAP4K21.90326590
20INSRR1.86593410
21GRK11.80848047
22DAPK11.75518962
23LIMK11.67858297
24TSSK61.65570346
25EIF2AK11.64074456
26STK391.57005546
27TESK11.41785951
28PDK21.29154120
29MAP4K11.26182890
30WNK41.22016451
31NME11.20806528
32OXSR11.18672515
33TRIM281.18564883
34PRKCQ1.16048715
35NEK11.13079587
36ITK1.11065626
37KIT1.10694500
38IKBKE1.10304428
39GRK61.04693416
40TEC1.02375908
41NME21.01243300
42FES0.98483908
43IKBKB0.98272113
44EIF2AK20.96857931
45MYLK0.96384489
46VRK10.93200373
47SYK0.90115919
48MAP3K40.88865485
49LCK0.85487145
50MKNK10.85052376
51PIM20.80091217
52PIK3CA0.79568926
53SCYL20.76097125
54JAK30.74106898
55BTK0.73873778
56MAPKAPK50.72232627
57PINK10.71756971
58RPS6KA50.70900857
59PHKG20.69383192
60PHKG10.69383192
61PLK20.67388728
62MAP3K60.62524578
63FRK0.60401144
64CSNK1G30.57759271
65OBSCN0.57150230
66PLK30.55749351
67MATK0.55430544
68STK160.55012374
69TNK20.53067182
70MAP2K20.50447470
71ARAF0.46875155
72CSNK1A1L0.46582991
73IGF1R0.46133635
74ERBB30.45878811
75LYN0.45848094
76PRKCI0.44889000
77MAP2K60.44276917
78PLK10.43409650
79CAMKK20.42250641
80ABL20.37573365
81GRK50.36793906
82AKT30.36761022
83ALK0.36444555
84ATR0.36315319
85CSK0.36081428
86ADRBK10.35949417
87ZAP700.35079823
88CSNK1G10.34358272
89SIK30.34339467
90INSR0.33275544
91CSNK2A10.33164467
92RPS6KA40.32797903
93MKNK20.31108460
94CAMK2G0.28227773
95EGFR0.27888308
96AURKA0.27730642
97MAPK130.26511094
98GRK70.26371295
99PAK40.25065055
100PRKCA0.24609930

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030506.19008719
2Primary immunodeficiency_Homo sapiens_hsa053404.18438513
3Oxidative phosphorylation_Homo sapiens_hsa001902.80782126
4Asthma_Homo sapiens_hsa053102.71378775
5Allograft rejection_Homo sapiens_hsa053302.66701590
6Autoimmune thyroid disease_Homo sapiens_hsa053202.65017512
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.29066689
8Graft-versus-host disease_Homo sapiens_hsa053322.25337744
9Parkinsons disease_Homo sapiens_hsa050122.22919773
10Antigen processing and presentation_Homo sapiens_hsa046122.10414240
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07125576
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89310060
13Type I diabetes mellitus_Homo sapiens_hsa049401.85731502
14Hematopoietic cell lineage_Homo sapiens_hsa046401.85204783
15Sulfur metabolism_Homo sapiens_hsa009201.76937334
16RNA polymerase_Homo sapiens_hsa030201.65679268
17Protein export_Homo sapiens_hsa030601.60633856
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53825849
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53596642
20One carbon pool by folate_Homo sapiens_hsa006701.46464473
21Alzheimers disease_Homo sapiens_hsa050101.43629509
22Propanoate metabolism_Homo sapiens_hsa006401.41281661
23T cell receptor signaling pathway_Homo sapiens_hsa046601.40769723
24Huntingtons disease_Homo sapiens_hsa050161.35678681
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32988006
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28165511
27Caffeine metabolism_Homo sapiens_hsa002321.24427984
28Ribosome_Homo sapiens_hsa030101.23851901
29Homologous recombination_Homo sapiens_hsa034401.23773558
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20472254
31RNA degradation_Homo sapiens_hsa030181.19741615
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14238432
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13703952
34Peroxisome_Homo sapiens_hsa041461.13657140
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.11034986
36Rheumatoid arthritis_Homo sapiens_hsa053231.09811371
37Tryptophan metabolism_Homo sapiens_hsa003801.09259363
38Phototransduction_Homo sapiens_hsa047441.04881782
39Pyrimidine metabolism_Homo sapiens_hsa002401.04692974
40Non-homologous end-joining_Homo sapiens_hsa034501.04585678
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02814406
42Mismatch repair_Homo sapiens_hsa034301.02723628
43Cardiac muscle contraction_Homo sapiens_hsa042601.01497349
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97165243
45Base excision repair_Homo sapiens_hsa034100.97012587
46Measles_Homo sapiens_hsa051620.95853406
47Linoleic acid metabolism_Homo sapiens_hsa005910.95654147
48Selenocompound metabolism_Homo sapiens_hsa004500.93205292
49Basal transcription factors_Homo sapiens_hsa030220.91510500
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90898620
51Butanoate metabolism_Homo sapiens_hsa006500.90673243
52Nitrogen metabolism_Homo sapiens_hsa009100.89651027
53Purine metabolism_Homo sapiens_hsa002300.85932633
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80993546
55Nucleotide excision repair_Homo sapiens_hsa034200.80938904
56Shigellosis_Homo sapiens_hsa051310.79524167
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79489533
58DNA replication_Homo sapiens_hsa030300.78127443
59Viral myocarditis_Homo sapiens_hsa054160.77053787
60Spliceosome_Homo sapiens_hsa030400.75520592
61Regulation of autophagy_Homo sapiens_hsa041400.73300324
62RNA transport_Homo sapiens_hsa030130.72347076
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71397836
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68037529
65Chemical carcinogenesis_Homo sapiens_hsa052040.64677727
66Olfactory transduction_Homo sapiens_hsa047400.62155270
67Fanconi anemia pathway_Homo sapiens_hsa034600.60043958
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59392254
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58081711
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.56810978
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.56688674
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55599250
73Herpes simplex infection_Homo sapiens_hsa051680.55407460
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.53396117
75Arachidonic acid metabolism_Homo sapiens_hsa005900.53141062
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50947779
77Retinol metabolism_Homo sapiens_hsa008300.50780775
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49103694
79beta-Alanine metabolism_Homo sapiens_hsa004100.48754079
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46427952
81Collecting duct acid secretion_Homo sapiens_hsa049660.45496598
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44649825
83Metabolic pathways_Homo sapiens_hsa011000.41951841
84Epstein-Barr virus infection_Homo sapiens_hsa051690.39682475
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.38053236
86Glutathione metabolism_Homo sapiens_hsa004800.35706630
87Systemic lupus erythematosus_Homo sapiens_hsa053220.35020328
88Circadian rhythm_Homo sapiens_hsa047100.34064932
89Sulfur relay system_Homo sapiens_hsa041220.33965578
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32163761
91Staphylococcus aureus infection_Homo sapiens_hsa051500.30684971
92Malaria_Homo sapiens_hsa051440.27872599
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.27829780
94Taste transduction_Homo sapiens_hsa047420.27547346
95ABC transporters_Homo sapiens_hsa020100.24559021
96Salmonella infection_Homo sapiens_hsa051320.24308080
97HTLV-I infection_Homo sapiens_hsa051660.23802929
98Legionellosis_Homo sapiens_hsa051340.23381389
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22879214
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21596496

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