PHBP13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)6.76864094
2gamma-aminobutyric acid transport (GO:0015812)6.74483048
3response to pheromone (GO:0019236)6.11956910
4DNA integration (GO:0015074)5.76713181
5negative regulation of interleukin-1 beta production (GO:0032691)5.13435832
6regulation of cholesterol esterification (GO:0010872)5.00884614
7regulation of cytokine secretion involved in immune response (GO:0002739)4.53623870
8phospholipid homeostasis (GO:0055091)4.45335589
9phospholipid efflux (GO:0033700)4.44086253
10protein-lipid complex assembly (GO:0065005)4.20626605
11keratinocyte development (GO:0003334)4.19130022
12peroxisome fission (GO:0016559)4.11611450
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.11268956
14negative regulation of gene silencing (GO:0060969)4.11008352
15negative regulation of interleukin-1 production (GO:0032692)4.10665055
16high-density lipoprotein particle remodeling (GO:0034375)3.86571508
17plasma lipoprotein particle assembly (GO:0034377)3.83426111
18regulation of gene silencing by miRNA (GO:0060964)3.81743851
19regulation of gene silencing by RNA (GO:0060966)3.81743851
20regulation of posttranscriptional gene silencing (GO:0060147)3.81743851
21regulation of heterotypic cell-cell adhesion (GO:0034114)3.81439232
22regulation of female receptivity (GO:0045924)3.74581896
23bile acid biosynthetic process (GO:0006699)3.63691938
24fatty acid elongation (GO:0030497)3.62463216
25rRNA catabolic process (GO:0016075)3.61962879
26regulation of alkaline phosphatase activity (GO:0010692)3.58857724
27reverse cholesterol transport (GO:0043691)3.58377978
28piRNA metabolic process (GO:0034587)3.54753389
29regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.50900436
30positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.49759141
31maturation of 5.8S rRNA (GO:0000460)3.46941268
32female mating behavior (GO:0060180)3.41813524
33positive regulation of Rho protein signal transduction (GO:0035025)3.38371657
34regulation of acyl-CoA biosynthetic process (GO:0050812)3.30215447
35dicarboxylic acid catabolic process (GO:0043649)3.29873120
36sex differentiation (GO:0007548)3.25354737
37regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)3.25077764
38S-adenosylmethionine metabolic process (GO:0046500)3.24218121
39transmission of nerve impulse (GO:0019226)3.23456043
40hippocampus development (GO:0021766)3.20375547
41mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.19752054
42positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.19752054
43male meiosis (GO:0007140)3.17365640
44regulation of Rac GTPase activity (GO:0032314)3.12237040
45male meiosis I (GO:0007141)3.10890729
46negative regulation of macrophage differentiation (GO:0045650)3.07211364
47regulation of interleukin-1 beta secretion (GO:0050706)3.06841848
48regulation of cofactor metabolic process (GO:0051193)3.04267301
49regulation of coenzyme metabolic process (GO:0051196)3.04267301
50synapsis (GO:0007129)3.02167000
51positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.99768514
52axon regeneration (GO:0031103)2.96676157
53phosphatidylcholine biosynthetic process (GO:0006656)2.95816899
54alpha-linolenic acid metabolic process (GO:0036109)2.94959895
55response to folic acid (GO:0051593)2.94292592
56water-soluble vitamin biosynthetic process (GO:0042364)2.92145838
57peptidyl-histidine modification (GO:0018202)2.91695925
58head development (GO:0060322)2.91246162
59neuronal action potential propagation (GO:0019227)2.90992202
60DNA double-strand break processing (GO:0000729)2.90351887
61cell migration involved in gastrulation (GO:0042074)2.88438654
62sequestering of actin monomers (GO:0042989)2.86922377
63glycosphingolipid biosynthetic process (GO:0006688)2.85547357
64regulation of cardioblast differentiation (GO:0051890)2.84462271
65respiratory chain complex IV assembly (GO:0008535)2.83845150
66negative chemotaxis (GO:0050919)2.82264112
67reflex (GO:0060004)2.81006567
68chromosome organization involved in meiosis (GO:0070192)2.80681880
69regulation of relaxation of muscle (GO:1901077)2.78375981
70photoreceptor cell maintenance (GO:0045494)2.73843303
71DNA dealkylation (GO:0035510)2.71124734
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.69618915
73meiotic chromosome segregation (GO:0045132)2.69008151
74outer ear morphogenesis (GO:0042473)2.67859905
75neurofilament cytoskeleton organization (GO:0060052)2.67324746
76regulation of interleukin-1 secretion (GO:0050704)2.66328385
77DNA methylation involved in gamete generation (GO:0043046)2.63436992
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.61958066
79carnitine transport (GO:0015879)2.60438678
80amino-acid betaine transport (GO:0015838)2.60438678
81negative regulation of lipase activity (GO:0060192)2.59765857
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.58361209
83positive regulation of CREB transcription factor activity (GO:0032793)2.57515265
84proteasome assembly (GO:0043248)2.56457793
85regulation of synapse assembly (GO:0051963)2.53848267
86regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.53753155
87prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.52863495
88positive regulation of protein homodimerization activity (GO:0090073)2.52500268
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52250210
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52250210
91otic vesicle formation (GO:0030916)2.52060148
92positive regulation of amino acid transport (GO:0051957)2.51605172
93cholesterol efflux (GO:0033344)2.50422204
94galactose catabolic process (GO:0019388)2.48947620
95meiosis I (GO:0007127)2.48152750
96ionotropic glutamate receptor signaling pathway (GO:0035235)2.47461888
97cholesterol catabolic process (GO:0006707)2.47344817
98sterol catabolic process (GO:0016127)2.47344817
99homocysteine metabolic process (GO:0050667)2.47128778
100negative regulation of oligodendrocyte differentiation (GO:0048715)2.46713777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.48465071
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.14774866
3GBX2_23144817_ChIP-Seq_PC3_Human3.09269112
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.97758173
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.78052343
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.48646763
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47140355
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.40277022
9IGF1R_20145208_ChIP-Seq_DFB_Human2.37224376
10EWS_26573619_Chip-Seq_HEK293_Human2.29402024
11FUS_26573619_Chip-Seq_HEK293_Human2.28113938
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26223834
13TAF15_26573619_Chip-Seq_HEK293_Human2.09935583
14P300_19829295_ChIP-Seq_ESCs_Human2.08403671
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.04166992
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01582888
17ZNF274_21170338_ChIP-Seq_K562_Hela1.97845253
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97354529
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89242517
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87523867
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87458132
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.83330772
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82994179
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.81200315
25RNF2_27304074_Chip-Seq_NSC_Mouse1.72098230
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69393612
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67653793
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65908218
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.64862425
30KLF5_20875108_ChIP-Seq_MESCs_Mouse1.62221071
31CBP_20019798_ChIP-Seq_JUKART_Human1.61027168
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61027168
33SMAD4_21799915_ChIP-Seq_A2780_Human1.60121471
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.57601485
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56400175
36AR_21572438_ChIP-Seq_LNCaP_Human1.54919059
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.53632473
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53286187
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53286187
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52323558
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51246341
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48583256
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43115139
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42116220
45ER_23166858_ChIP-Seq_MCF-7_Human1.40139450
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37383602
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37361562
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.35357076
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34831797
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.34406592
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34127512
52STAT3_23295773_ChIP-Seq_U87_Human1.32217612
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31404039
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31014351
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30064650
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.27997709
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27724120
58TCF4_23295773_ChIP-Seq_U87_Human1.27703542
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26114197
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.25734269
61TP53_22573176_ChIP-Seq_HFKS_Human1.24648464
62AR_25329375_ChIP-Seq_VCAP_Human1.24646592
63LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22328585
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21616765
65TBL1_22424771_ChIP-Seq_293T_Human1.19968142
66TCF4_22108803_ChIP-Seq_LS180_Human1.19873569
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18251882
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16601878
69TAL1_26923725_Chip-Seq_HPCs_Mouse1.15834405
70NFYB_21822215_ChIP-Seq_K562_Human1.15754316
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15546586
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.15112805
73HTT_18923047_ChIP-ChIP_STHdh_Human1.14292381
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.13396362
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.11540294
76ELK1_19687146_ChIP-ChIP_HELA_Human1.10764911
77SOX2_19829295_ChIP-Seq_ESCs_Human1.10450651
78NANOG_19829295_ChIP-Seq_ESCs_Human1.10450651
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10016800
80BCAT_22108803_ChIP-Seq_LS180_Human1.09669577
81REST_21632747_ChIP-Seq_MESCs_Mouse1.09617088
82PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08980954
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08847009
84PHF8_20622853_ChIP-Seq_HELA_Human1.08613602
85MYC_18940864_ChIP-ChIP_HL60_Human1.04879422
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03901807
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03803303
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03443324
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02989081
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01723655
91AR_20517297_ChIP-Seq_VCAP_Human1.01377811
92NFYA_21822215_ChIP-Seq_K562_Human0.99871080
93VDR_22108803_ChIP-Seq_LS180_Human0.99808602
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99529069
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99529069
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99529069
97CBP_21632823_ChIP-Seq_H3396_Human0.99105703
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98978446
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.98624837
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96984892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.46517878
2MP0008004_abnormal_stomach_pH3.76703533
3MP0003646_muscle_fatigue3.64440751
4MP0005377_hearing/vestibular/ear_phenot3.38512321
5MP0003878_abnormal_ear_physiology3.38512321
6MP0001986_abnormal_taste_sensitivity3.17866405
7MP0004885_abnormal_endolymph3.04698509
8MP0008877_abnormal_DNA_methylation2.98214905
9MP0009840_abnormal_foam_cell2.63194643
10MP0000537_abnormal_urethra_morphology2.56010901
11MP0003191_abnormal_cellular_cholesterol2.25192673
12MP0000516_abnormal_urinary_system2.16406466
13MP0005367_renal/urinary_system_phenotyp2.16406466
14MP0003119_abnormal_digestive_system2.12150550
15MP0009046_muscle_twitch2.03105763
16MP0002102_abnormal_ear_morphology1.96650913
17MP0006276_abnormal_autonomic_nervous1.94371224
18MP0002736_abnormal_nociception_after1.92754825
19MP0005408_hypopigmentation1.89415640
20MP0008057_abnormal_DNA_replication1.86019086
21MP0004142_abnormal_muscle_tone1.75256742
22MP0003880_abnormal_central_pattern1.73855596
23MP0003693_abnormal_embryo_hatching1.72985699
24MP0005551_abnormal_eye_electrophysiolog1.70551434
25MP0003315_abnormal_perineum_morphology1.64131489
26MP0004147_increased_porphyrin_level1.63461582
27MP0002822_catalepsy1.59840717
28MP0002837_dystrophic_cardiac_calcinosis1.55667155
29MP0004270_analgesia1.53554354
30MP0002638_abnormal_pupillary_reflex1.52635687
31MP0000639_abnormal_adrenal_gland1.49997334
32MP0005187_abnormal_penis_morphology1.49396477
33MP0002909_abnormal_adrenal_gland1.47909440
34MP0005423_abnormal_somatic_nervous1.44661940
35MP0006072_abnormal_retinal_apoptosis1.44565901
36MP0001968_abnormal_touch/_nociception1.43288016
37MP0009745_abnormal_behavioral_response1.42672354
38MP0005253_abnormal_eye_physiology1.42326984
39MP0005248_abnormal_Harderian_gland1.41541778
40MP0008789_abnormal_olfactory_epithelium1.41274610
41MP0002160_abnormal_reproductive_system1.40504538
42MP0002277_abnormal_respiratory_mucosa1.39936720
43MP0000631_abnormal_neuroendocrine_gland1.37673186
44MP0002734_abnormal_mechanical_nocicepti1.32036342
45MP0005499_abnormal_olfactory_system1.30643269
46MP0005394_taste/olfaction_phenotype1.30643269
47MP0003879_abnormal_hair_cell1.29794891
48MP0001486_abnormal_startle_reflex1.22921520
49MP0001188_hyperpigmentation1.20700659
50MP0002233_abnormal_nose_morphology1.20551396
51MP0002184_abnormal_innervation1.19204016
52MP0002735_abnormal_chemical_nociception1.17312648
53MP0001984_abnormal_olfaction1.16394253
54MP0004043_abnormal_pH_regulation1.14995276
55MP0001666_abnormal_nutrient_absorption1.13672366
56MP0000778_abnormal_nervous_system1.12797166
57MP0001963_abnormal_hearing_physiology1.11115633
58MP0000383_abnormal_hair_follicle1.09341340
59MP0000049_abnormal_middle_ear1.07843526
60MP0010329_abnormal_lipoprotein_level1.07632396
61MP0002272_abnormal_nervous_system1.03494067
62MP0003195_calcinosis1.02061739
63MP0001919_abnormal_reproductive_system1.01774695
64MP0003698_abnormal_male_reproductive1.01282043
65MP0008995_early_reproductive_senescence0.99243847
66MP0003385_abnormal_body_wall0.98874668
67MP0002210_abnormal_sex_determination0.98728965
68MP0001440_abnormal_grooming_behavior0.96577423
69MP0002090_abnormal_vision0.95935339
70MP0000647_abnormal_sebaceous_gland0.95428326
71MP0002557_abnormal_social/conspecific_i0.94548568
72MP0003937_abnormal_limbs/digits/tail_de0.89774709
73MP0001929_abnormal_gametogenesis0.89701106
74MP0001664_abnormal_digestion0.88668575
75MP0003122_maternal_imprinting0.88007493
76MP0000026_abnormal_inner_ear0.86322207
77MP0005389_reproductive_system_phenotype0.85240308
78MP0008872_abnormal_physiological_respon0.85171639
79MP0002572_abnormal_emotion/affect_behav0.84711058
80MP0003787_abnormal_imprinting0.83845597
81MP0005075_abnormal_melanosome_morpholog0.82633956
82MP0004859_abnormal_synaptic_plasticity0.82418991
83MP0002067_abnormal_sensory_capabilities0.82128499
84MP0003635_abnormal_synaptic_transmissio0.80956308
85MP0002069_abnormal_eating/drinking_beha0.80615631
86MP0002064_seizures0.79484840
87MP0001905_abnormal_dopamine_level0.78973719
88MP0001145_abnormal_male_reproductive0.78941605
89MP0001529_abnormal_vocalization0.78601245
90MP0001324_abnormal_eye_pigmentation0.78436015
91MP0000653_abnormal_sex_gland0.77814158
92MP0005645_abnormal_hypothalamus_physiol0.77428007
93MP0001485_abnormal_pinna_reflex0.76482856
94MP0002752_abnormal_somatic_nervous0.76426796
95MP0004085_abnormal_heartbeat0.73914162
96MP0000427_abnormal_hair_cycle0.70782436
97MP0003137_abnormal_impulse_conducting0.70398291
98MP0001243_abnormal_dermal_layer0.70313189
99MP0005386_behavior/neurological_phenoty0.69456717
100MP0004924_abnormal_behavior0.69456717

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)5.26473525
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.89237571
3Spontaneous abortion (HP:0005268)3.95631919
4Papilledema (HP:0001085)3.82046635
5Amyloidosis (HP:0011034)3.80131204
6Hypoalphalipoproteinemia (HP:0003233)3.76963582
7Intrahepatic cholestasis (HP:0001406)3.65708155
8Rectal fistula (HP:0100590)3.57714345
9Rectovaginal fistula (HP:0000143)3.57714345
10Chronic bronchitis (HP:0004469)3.34305092
11Pendular nystagmus (HP:0012043)3.28899379
12Intestinal fistula (HP:0100819)3.26889479
13Split foot (HP:0001839)3.23751068
14Oligodactyly (hands) (HP:0001180)3.17363130
15Acute necrotizing encephalopathy (HP:0006965)3.10254473
16Severe visual impairment (HP:0001141)3.08909050
17Acute encephalopathy (HP:0006846)3.04940679
18Renal cortical cysts (HP:0000803)2.95836489
19Tubulointerstitial nephritis (HP:0001970)2.95091841
20Rhinitis (HP:0012384)2.93024587
21Partial duplication of the phalanx of hand (HP:0009999)2.89101576
22Amyotrophic lateral sclerosis (HP:0007354)2.88736769
23Vaginal fistula (HP:0004320)2.87483990
24Increased hepatocellular lipid droplets (HP:0006565)2.81490390
25Pancreatic cysts (HP:0001737)2.80372715
26Horizontal nystagmus (HP:0000666)2.75390618
27Intestinal atresia (HP:0011100)2.71861391
28Turricephaly (HP:0000262)2.67381557
29Steatorrhea (HP:0002570)2.64455924
30Abnormal respiratory motile cilium physiology (HP:0012261)2.64334367
31Abnormality of the renal cortex (HP:0011035)2.57065475
32Hypolipoproteinemia (HP:0010981)2.52845069
33Fat malabsorption (HP:0002630)2.51958215
34Poor suck (HP:0002033)2.51707540
35Abnormal mitochondria in muscle tissue (HP:0008316)2.49616388
36Abolished electroretinogram (ERG) (HP:0000550)2.49329941
37Abnormality of the labia minora (HP:0012880)2.47476426
38Vacuolated lymphocytes (HP:0001922)2.47033758
39Progressive macrocephaly (HP:0004481)2.44526834
40Large for gestational age (HP:0001520)2.42997282
41Papillary thyroid carcinoma (HP:0002895)2.42853030
42Aplasia/Hypoplasia involving the musculature (HP:0001460)2.42754772
43Posterior subcapsular cataract (HP:0007787)2.41554726
44Mitochondrial inheritance (HP:0001427)2.41520837
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35861411
46Fibular aplasia (HP:0002990)2.32516290
47Hypothermia (HP:0002045)2.30895212
48Pancreatic islet-cell hyperplasia (HP:0004510)2.27470280
49Increased CSF lactate (HP:0002490)2.26936283
50Respiratory difficulties (HP:0002880)2.25442717
51Medial flaring of the eyebrow (HP:0010747)2.24239423
52Renal Fanconi syndrome (HP:0001994)2.20851367
53Hyperglycinemia (HP:0002154)2.18568310
543-Methylglutaconic aciduria (HP:0003535)2.14518299
55Type I transferrin isoform profile (HP:0003642)2.13599011
56Generalized aminoaciduria (HP:0002909)2.13172538
57Chorioretinal atrophy (HP:0000533)2.12862586
58Absent speech (HP:0001344)2.11610050
59Progressive sensorineural hearing impairment (HP:0000408)2.11331288
60Oligodactyly (HP:0012165)2.10999071
61Attenuation of retinal blood vessels (HP:0007843)2.10253580
62Hypoplastic pelvis (HP:0008839)2.09221266
63Lipid accumulation in hepatocytes (HP:0006561)2.08239648
64Retinal atrophy (HP:0001105)2.08101122
65Congenital primary aphakia (HP:0007707)2.07246807
66Epidermoid cyst (HP:0200040)2.03907826
67Ketoacidosis (HP:0001993)2.03221284
68Delayed CNS myelination (HP:0002188)2.03030591
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01451182
70Gait imbalance (HP:0002141)2.01031858
71Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.00274856
72Severe Myopia (HP:0011003)1.99691199
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99119490
74Abnormal protein N-linked glycosylation (HP:0012347)1.99119490
75Abnormal protein glycosylation (HP:0012346)1.99119490
76Abnormal glycosylation (HP:0012345)1.99119490
77Genital tract atresia (HP:0001827)1.97502580
78Epileptic encephalopathy (HP:0200134)1.96485581
79Bifid tongue (HP:0010297)1.96134261
80Hepatocellular necrosis (HP:0001404)1.95161629
81Abnormal albumin level (HP:0012116)1.92091975
82Hypoalbuminemia (HP:0003073)1.92091975
83Vaginal atresia (HP:0000148)1.89181015
84Abnormality of renal resorption (HP:0011038)1.88901171
85Fetal akinesia sequence (HP:0001989)1.88606989
86Neonatal onset (HP:0003623)1.87914625
87Partial duplication of thumb phalanx (HP:0009944)1.86990694
88Methylmalonic acidemia (HP:0002912)1.85586222
89Proximal tubulopathy (HP:0000114)1.84002900
90Abnormality of the phalanges of the 2nd finger (HP:0009541)1.83794509
91Poor coordination (HP:0002370)1.83034850
92Nephronophthisis (HP:0000090)1.82597464
93Colon cancer (HP:0003003)1.82199844
94Aplasia/hypoplasia of the uterus (HP:0008684)1.82173525
95Gingival bleeding (HP:0000225)1.81620957
96Abnormal rod and cone electroretinograms (HP:0008323)1.80520097
97Exertional dyspnea (HP:0002875)1.79462714
98Nephrotic syndrome (HP:0000100)1.76810645
99Hypoplastic left heart (HP:0004383)1.76779804
100Glycosuria (HP:0003076)1.76229894

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K45.17708322
2CDK194.83929042
3PNCK4.63425146
4MAP2K74.25418830
5WNK33.75255153
6PASK3.39226620
7MAPK133.32022686
8PDK22.64770472
9EIF2AK12.63860478
10EPHA42.08082971
11MAP2K42.04643374
12MAP3K92.04601473
13EIF2AK32.00756935
14PRKD31.94027516
15GRK11.68435886
16MET1.66648096
17STK381.66492572
18TRIM281.58504485
19DAPK21.53934789
20CAMKK11.51036481
21BCR1.41411909
22CASK1.41350169
23TAOK31.40181351
24ERBB31.34625921
25NME11.32332720
26CCNB11.24647025
27TYRO31.11983758
28STK38L1.11574439
29MST41.07555770
30FGR1.04202687
31TESK20.98267263
32PTK2B0.97648559
33MARK10.96214717
34LMTK20.95324966
35SRPK10.95101489
36ZAK0.95049743
37LIMK10.93858933
38BMX0.93801998
39PLK40.92287362
40MAP4K20.91946126
41MAP3K60.90879784
42CSF1R0.89722659
43VRK10.79895658
44PRKCE0.79423529
45CAMKK20.73979046
46PLK20.73028881
47PRKCG0.71275984
48PDGFRB0.68897274
49RPS6KB10.68679030
50CAMK1G0.62553736
51PKN10.61098079
52FRK0.60363718
53OXSR10.59351012
54BRD40.58510479
55TESK10.56992328
56AKT30.54461288
57NTRK20.52917523
58INSRR0.51688115
59RET0.50333079
60CSNK1G30.49308684
61CSNK1G20.48010659
62BMPR20.46606194
63PINK10.46353744
64DYRK30.44520595
65CAMK2A0.44117074
66PAK30.43712566
67OBSCN0.43682727
68ATR0.43094729
69CSNK1G10.42155986
70PRKACB0.41944229
71EPHA30.41086723
72KDR0.40466645
73FGFR10.38428497
74MINK10.36110871
75STK110.36037663
76ATM0.34663894
77KSR10.33815573
78EGFR0.33571890
79ROCK10.31451729
80ERBB40.31373384
81SCYL20.29573935
82CDK50.28200543
83ERBB20.27154327
84CSNK1A1L0.25073046
85IGF1R0.23796777
86CSNK1D0.23481603
87RPS6KA20.22161598
88PRKACA0.22103842
89PRKCA0.21278350
90KIT0.19923455
91DDR20.19892304
92UHMK10.19884650
93MAP3K100.18569535
94CAMK40.18380340
95PDK10.18264815
96CAMK10.18035529
97PAK10.17639236
98RPS6KA40.17584664
99PDPK10.17580029
100WEE10.16271596

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001205.55776160
2Protein export_Homo sapiens_hsa030603.44599768
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.14309516
4Nicotine addiction_Homo sapiens_hsa050333.02565164
5Fat digestion and absorption_Homo sapiens_hsa049752.79983583
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.63907923
7Vitamin digestion and absorption_Homo sapiens_hsa049772.51892498
8Oxidative phosphorylation_Homo sapiens_hsa001902.44951482
9GABAergic synapse_Homo sapiens_hsa047272.24083185
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23457767
11Circadian rhythm_Homo sapiens_hsa047102.18066118
12RNA degradation_Homo sapiens_hsa030182.16394939
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09888455
14Parkinsons disease_Homo sapiens_hsa050121.90940178
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86409557
16Morphine addiction_Homo sapiens_hsa050321.85613382
17N-Glycan biosynthesis_Homo sapiens_hsa005101.55177591
18Butanoate metabolism_Homo sapiens_hsa006501.51189310
19Dopaminergic synapse_Homo sapiens_hsa047281.50723061
20Circadian entrainment_Homo sapiens_hsa047131.50540862
21Nucleotide excision repair_Homo sapiens_hsa034201.47524487
22Taste transduction_Homo sapiens_hsa047421.47318335
23Phototransduction_Homo sapiens_hsa047441.46235085
24Peroxisome_Homo sapiens_hsa041461.41334928
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37506695
26Fatty acid elongation_Homo sapiens_hsa000621.31221180
27Alcoholism_Homo sapiens_hsa050341.30152458
28Synaptic vesicle cycle_Homo sapiens_hsa047211.16911251
29Pyruvate metabolism_Homo sapiens_hsa006201.10774386
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10330837
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08303999
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06554077
33Collecting duct acid secretion_Homo sapiens_hsa049661.05377497
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04953998
35Olfactory transduction_Homo sapiens_hsa047401.03952941
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98573386
37Cholinergic synapse_Homo sapiens_hsa047250.96795346
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96134517
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95690358
40Regulation of autophagy_Homo sapiens_hsa041400.95225479
41Oocyte meiosis_Homo sapiens_hsa041140.95187490
42Huntingtons disease_Homo sapiens_hsa050160.94963940
43Amphetamine addiction_Homo sapiens_hsa050310.94290823
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.92058920
45Nitrogen metabolism_Homo sapiens_hsa009100.91631634
46Glutamatergic synapse_Homo sapiens_hsa047240.91255426
47Serotonergic synapse_Homo sapiens_hsa047260.90952580
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90812490
49Alzheimers disease_Homo sapiens_hsa050100.90112857
50Cardiac muscle contraction_Homo sapiens_hsa042600.89813729
51Selenocompound metabolism_Homo sapiens_hsa004500.88811517
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.87986831
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.84949273
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84363618
55Basal transcription factors_Homo sapiens_hsa030220.82794909
56Insulin secretion_Homo sapiens_hsa049110.80232883
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75093921
58Type II diabetes mellitus_Homo sapiens_hsa049300.74817940
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70194867
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68282130
61Steroid biosynthesis_Homo sapiens_hsa001000.65591545
62Other glycan degradation_Homo sapiens_hsa005110.65129709
63Systemic lupus erythematosus_Homo sapiens_hsa053220.64248175
64Sulfur metabolism_Homo sapiens_hsa009200.62740354
65Purine metabolism_Homo sapiens_hsa002300.61688855
66Metabolic pathways_Homo sapiens_hsa011000.61304624
67African trypanosomiasis_Homo sapiens_hsa051430.59193507
68Long-term potentiation_Homo sapiens_hsa047200.58219348
69beta-Alanine metabolism_Homo sapiens_hsa004100.57872023
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57023653
71Cocaine addiction_Homo sapiens_hsa050300.54889892
72Primary immunodeficiency_Homo sapiens_hsa053400.54168273
73Axon guidance_Homo sapiens_hsa043600.53782526
74Retinol metabolism_Homo sapiens_hsa008300.48279508
75cAMP signaling pathway_Homo sapiens_hsa040240.47511482
76RNA transport_Homo sapiens_hsa030130.47468435
77Fanconi anemia pathway_Homo sapiens_hsa034600.44870017
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43698024
79DNA replication_Homo sapiens_hsa030300.42736547
80Glucagon signaling pathway_Homo sapiens_hsa049220.42706760
81Mismatch repair_Homo sapiens_hsa034300.42633663
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42312052
83Arachidonic acid metabolism_Homo sapiens_hsa005900.40831164
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40482444
85Glycerolipid metabolism_Homo sapiens_hsa005610.39593609
86Linoleic acid metabolism_Homo sapiens_hsa005910.39241134
87ErbB signaling pathway_Homo sapiens_hsa040120.38271858
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35834752
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35057789
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31860825
91Calcium signaling pathway_Homo sapiens_hsa040200.29989326
92Hedgehog signaling pathway_Homo sapiens_hsa043400.29208278
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27492536
94Ether lipid metabolism_Homo sapiens_hsa005650.27464651
95Lysine degradation_Homo sapiens_hsa003100.27359943
96Gastric acid secretion_Homo sapiens_hsa049710.27227678
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25751860
98Base excision repair_Homo sapiens_hsa034100.23438965
99Propanoate metabolism_Homo sapiens_hsa006400.22236558
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21900147

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