PHACTR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the phosphatase and actin regulator family of proteins. This family member can bind actin and regulate the reorganization of the actin cytoskeleton. It plays a role in tubule formation and in endothelial cell survival. Polymorphisms in this gene are associated with susceptibility to myocardial infarction, coronary artery disease and cervical artery dissection. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenol-containing compound biosynthetic process (GO:0046189)7.92417207
2melanosome organization (GO:0032438)7.63544449
3pigment granule organization (GO:0048753)7.30999324
4retinal rod cell development (GO:0046548)6.72125142
5developmental pigmentation (GO:0048066)6.67657403
6melanocyte differentiation (GO:0030318)6.56980718
7pigment cell differentiation (GO:0050931)6.40463594
8pigment biosynthetic process (GO:0046148)6.25938028
9ketone body metabolic process (GO:1902224)5.67315440
10regulation of short-term neuronal synaptic plasticity (GO:0048172)5.63053089
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.54314312
12synaptic vesicle maturation (GO:0016188)5.47991002
13pigment metabolic process (GO:0042440)5.43326790
14locomotory exploration behavior (GO:0035641)5.33513899
15inositol phosphate catabolic process (GO:0071545)5.26252620
16response to epinephrine (GO:0071871)5.14323509
17secondary metabolic process (GO:0019748)5.09349030
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.08018256
19synaptic vesicle exocytosis (GO:0016079)4.97780494
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.91860520
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.90161588
22vocalization behavior (GO:0071625)4.85689958
23regulation of synaptic vesicle exocytosis (GO:2000300)4.80935532
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.76397564
25regulation of synapse structural plasticity (GO:0051823)4.69387371
26neuroepithelial cell differentiation (GO:0060563)4.69146576
27calcium-mediated signaling using intracellular calcium source (GO:0035584)4.64825181
28regulation of glutamate receptor signaling pathway (GO:1900449)4.62841298
29inositol phosphate dephosphorylation (GO:0046855)4.58541701
30phosphorylated carbohydrate dephosphorylation (GO:0046838)4.58541701
31negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.57269326
32regulation of DNA endoreduplication (GO:0032875)4.47224951
33glutamate secretion (GO:0014047)4.46349452
34regulation of long-term neuronal synaptic plasticity (GO:0048169)4.45854640
35regulation of neuronal synaptic plasticity (GO:0048168)4.41102686
36neuronal action potential propagation (GO:0019227)4.38549388
37negative regulation of interleukin-1 beta production (GO:0032691)4.36742767
38protein localization to synapse (GO:0035418)4.35816360
39polyol catabolic process (GO:0046174)4.28794171
40regulation of synaptic vesicle transport (GO:1902803)4.27627657
41neurotransmitter-gated ion channel clustering (GO:0072578)4.26209993
42regulation of integrin-mediated signaling pathway (GO:2001044)4.25347275
43ionotropic glutamate receptor signaling pathway (GO:0035235)4.22078240
44melanosome transport (GO:0032402)4.19981892
45cellular response to reactive nitrogen species (GO:1902170)4.13732686
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.13635393
47tyrosine metabolic process (GO:0006570)4.07844156
48synaptic transmission, glutamatergic (GO:0035249)4.02270641
49neurotransmitter secretion (GO:0007269)3.99500880
50neuron-neuron synaptic transmission (GO:0007270)3.98472677
51establishment of melanosome localization (GO:0032401)3.98451675
52exploration behavior (GO:0035640)3.98223768
53pigment granule transport (GO:0051904)3.97849866
54neuron cell-cell adhesion (GO:0007158)3.96894108
55regulation of superoxide anion generation (GO:0032928)3.95490211
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.93791262
57prepulse inhibition (GO:0060134)3.90593765
58positive regulation of membrane potential (GO:0045838)3.89902977
59dendritic spine morphogenesis (GO:0060997)3.88793069
60auditory behavior (GO:0031223)3.87403098
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.87110642
62regulation of cellular respiration (GO:0043457)3.85369616
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.83942403
64piRNA metabolic process (GO:0034587)3.82013393
65positive regulation of receptor recycling (GO:0001921)3.79624191
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.79142702
67establishment of pigment granule localization (GO:0051905)3.78218007
68synaptic transmission, dopaminergic (GO:0001963)3.75905652
69regulation of dendritic spine morphogenesis (GO:0061001)3.74498962
70negative regulation of organelle assembly (GO:1902116)3.74335752
71long-term memory (GO:0007616)3.74052043
72melanosome localization (GO:0032400)3.73731125
73striatum development (GO:0021756)3.72220772
74positive regulation of neurotransmitter transport (GO:0051590)3.68279886
75glutamate receptor signaling pathway (GO:0007215)3.66801836
76positive regulation of neurotransmitter secretion (GO:0001956)3.63119626
77regulation of postsynaptic membrane potential (GO:0060078)3.62282793
78negative regulation of interleukin-1 production (GO:0032692)3.61504546
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.59724626
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.59174944
81regulation of synaptic plasticity (GO:0048167)3.57591661
82pigment granule localization (GO:0051875)3.56104973
83transmission of nerve impulse (GO:0019226)3.52936021
84behavioral response to cocaine (GO:0048148)3.50496927
85positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.50271975
86regulation of synaptic transmission, glutamatergic (GO:0051966)3.47757009
87long-term synaptic potentiation (GO:0060291)3.47295621
88adenosine receptor signaling pathway (GO:0001973)3.46793104
89response to auditory stimulus (GO:0010996)3.46537299
90layer formation in cerebral cortex (GO:0021819)3.46127655
91pigmentation (GO:0043473)3.45318816
92negative regulation of neurological system process (GO:0031645)3.44746328
93activation of protein kinase A activity (GO:0034199)3.44035831
94neuromuscular process controlling balance (GO:0050885)3.42313366
95G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.41535467
96adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.40256505
97gamma-aminobutyric acid transport (GO:0015812)3.40023058
98signal peptide processing (GO:0006465)3.39967629
99negative regulation of TOR signaling (GO:0032007)3.39310114
100presynaptic membrane assembly (GO:0097105)3.36165370
101cullin deneddylation (GO:0010388)3.36104647
102proteasome assembly (GO:0043248)3.36093999
103regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.35862257
104regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.35862257
105neuronal ion channel clustering (GO:0045161)3.35364370
106dopamine transport (GO:0015872)3.32475169
107regulation of neurotransmitter secretion (GO:0046928)3.29507604
108negative regulation of acute inflammatory response (GO:0002674)3.26354564
109negative regulation of JUN kinase activity (GO:0043508)3.26085020
110response to amphetamine (GO:0001975)3.25500851
111positive regulation of response to oxidative stress (GO:1902884)3.24409337
112positive regulation of cellular response to oxidative stress (GO:1900409)3.24409337
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.23635244
114detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.22452593
115regulation of female receptivity (GO:0045924)3.20779680
116neurotransmitter transport (GO:0006836)3.20459052
117negative regulation of receptor-mediated endocytosis (GO:0048261)3.19989798
118regulation of neurotransmitter transport (GO:0051588)3.19247533
119presynaptic membrane organization (GO:0097090)3.18631534
120postsynaptic membrane organization (GO:0001941)3.18129191
121membrane hyperpolarization (GO:0060081)3.16960988
122mechanosensory behavior (GO:0007638)3.16395832
123dopamine receptor signaling pathway (GO:0007212)3.15236371
124regulation of glutamate secretion (GO:0014048)3.14941719
125regulation of voltage-gated calcium channel activity (GO:1901385)3.14243910
126cAMP catabolic process (GO:0006198)3.13679491
127positive regulation of protein autophosphorylation (GO:0031954)3.13568896
128regulation of vesicle fusion (GO:0031338)3.12928861
129negative regulation of DNA-dependent DNA replication (GO:2000104)3.12511335
130membrane depolarization (GO:0051899)3.10106428
131regulation of dendritic spine development (GO:0060998)3.09541183
132detection of calcium ion (GO:0005513)3.08603828
133response to muscle activity (GO:0014850)3.07760105
134synapsis (GO:0007129)3.07756498
135dendritic spine organization (GO:0097061)3.07215350
136flavonoid metabolic process (GO:0009812)3.07043119
137neuron recognition (GO:0008038)3.03094346
138learning (GO:0007612)3.03040817
139positive regulation of synaptic transmission (GO:0050806)3.02316464
140glycine transport (GO:0015816)3.02166745
141visual learning (GO:0008542)3.02131056
142regulation of synaptic transmission, GABAergic (GO:0032228)3.01023240
143behavioral defense response (GO:0002209)3.00513757
144behavioral fear response (GO:0001662)3.00513757
145negative regulation of synaptic transmission, GABAergic (GO:0032229)3.00302790
146regulation of neurotransmitter levels (GO:0001505)3.00212966
147protein deneddylation (GO:0000338)3.00121025
148response to histamine (GO:0034776)2.99516878
149regulation of acyl-CoA biosynthetic process (GO:0050812)2.98983875
150phenol-containing compound metabolic process (GO:0018958)2.98885668
151cyclic nucleotide catabolic process (GO:0009214)2.98330129
152centrosome duplication (GO:0051298)2.97479555
153membrane depolarization during action potential (GO:0086010)2.97271512
154female mating behavior (GO:0060180)2.96297269
155acrosome reaction (GO:0007340)2.94838445
156positive regulation of synapse maturation (GO:0090129)2.94592203
157vesicle transport along microtubule (GO:0047496)2.93053089
158regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.92883594
159DNA methylation involved in gamete generation (GO:0043046)2.92514664
160auditory receptor cell stereocilium organization (GO:0060088)2.91898214
161negative regulation of dendrite development (GO:2000171)2.91882825
162cellular potassium ion homeostasis (GO:0030007)2.91084095
163gamma-aminobutyric acid signaling pathway (GO:0007214)2.90349629
164regulation of clathrin-mediated endocytosis (GO:2000369)2.90024396
165proline transport (GO:0015824)2.89860646
166synaptic vesicle endocytosis (GO:0048488)2.88824078
167visual behavior (GO:0007632)2.88228633
168regulation of early endosome to late endosome transport (GO:2000641)2.86744757
169male meiosis (GO:0007140)2.84151624
170protein K11-linked deubiquitination (GO:0035871)2.83764404
171regulation of sulfur metabolic process (GO:0042762)2.78824168
172negative regulation of membrane potential (GO:0045837)2.77561143
173regulation of neurotransmitter uptake (GO:0051580)2.76143454
174kinetochore assembly (GO:0051382)2.75614862
175cellular response to epinephrine stimulus (GO:0071872)2.65979192
176regulation of inositol phosphate biosynthetic process (GO:0010919)2.65247333
177regulation of coenzyme metabolic process (GO:0051196)2.65081470
178regulation of cofactor metabolic process (GO:0051193)2.65081470
179negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.63844570
180regulation of superoxide metabolic process (GO:0090322)2.62788641
181galactose metabolic process (GO:0006012)2.62194396
182cornea development in camera-type eye (GO:0061303)2.62190304
183columnar/cuboidal epithelial cell differentiation (GO:0002065)2.60814044
184negative regulation of chemokine production (GO:0032682)2.60645398
185mitotic G2 DNA damage checkpoint (GO:0007095)2.59779975
186sympathetic nervous system development (GO:0048485)2.59370323
187short-chain fatty acid metabolic process (GO:0046459)2.56675864
188regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.56566774
189cellular response to thyroid hormone stimulus (GO:0097067)2.54452795
190kinetochore organization (GO:0051383)2.52016463
191endosome to melanosome transport (GO:0035646)2.51499890
192endosome to pigment granule transport (GO:0043485)2.51499890
193myelin assembly (GO:0032288)2.51370405
194regulation of myelination (GO:0031641)2.50156457
195melanin biosynthetic process (GO:0042438)19.9917368
196melanin metabolic process (GO:0006582)18.3653851
197secondary metabolite biosynthetic process (GO:0044550)17.1087463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.02033811
2EZH2_22144423_ChIP-Seq_EOC_Human5.48536734
3E2F7_22180533_ChIP-Seq_HELA_Human4.48982924
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.52507620
5* GBX2_23144817_ChIP-Seq_PC3_Human3.43905781
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.23306450
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14196305
8RARB_27405468_Chip-Seq_BRAIN_Mouse3.13295014
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01523349
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93520819
11REST_21632747_ChIP-Seq_MESCs_Mouse2.79324138
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.71595370
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64589251
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62988166
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62988166
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57845833
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56181059
18FUS_26573619_Chip-Seq_HEK293_Human2.53805043
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51928871
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51835109
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.50937894
22* DROSHA_22980978_ChIP-Seq_HELA_Human2.50711724
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.49347269
24VDR_22108803_ChIP-Seq_LS180_Human2.42416057
25* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33174445
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29483214
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.26462491
28* REST_18959480_ChIP-ChIP_MESCs_Mouse2.23663069
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19942571
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.15684964
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.14996508
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14924815
33EST1_17652178_ChIP-ChIP_JURKAT_Human2.10818173
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10305964
35GABP_17652178_ChIP-ChIP_JURKAT_Human2.10156670
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.98883640
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92272852
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90373826
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90217779
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82953325
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80310335
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79082319
43AUTS2_25519132_ChIP-Seq_293T-REX_Human1.78809896
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78312503
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77127878
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.77056942
47AR_21572438_ChIP-Seq_LNCaP_Human1.76781633
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.74525469
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73952912
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71094774
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70384975
52TAF15_26573619_Chip-Seq_HEK293_Human1.65719680
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.63510932
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.60893086
55* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58593246
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.57704714
57ELK1_19687146_ChIP-ChIP_HELA_Human1.56232683
58* SMAD4_21799915_ChIP-Seq_A2780_Human1.55642832
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53833793
60ER_23166858_ChIP-Seq_MCF-7_Human1.48551687
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47956496
62CBP_20019798_ChIP-Seq_JUKART_Human1.47956496
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47891775
64MYC_18940864_ChIP-ChIP_HL60_Human1.47766807
65TFEB_21752829_ChIP-Seq_HELA_Human1.43164458
66EWS_26573619_Chip-Seq_HEK293_Human1.42324213
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41672731
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.40128542
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38666513
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37838035
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37730479
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36050621
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35762629
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35351669
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.34416133
76P53_22387025_ChIP-Seq_ESCs_Mouse1.34174686
77* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32365998
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31274078
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30374749
80P300_19829295_ChIP-Seq_ESCs_Human1.30078304
81STAT3_23295773_ChIP-Seq_U87_Human1.29228233
82* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27769184
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27580245
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27443640
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26714970
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26673958
87OCT4_18555785_Chip-Seq_ESCs_Mouse1.23032055
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.22481568
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21544338
90* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21519424
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.21326374
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21041841
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20744513
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.19932370
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18905834
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18868760
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18298404
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18155668
99SOX2_18555785_Chip-Seq_ESCs_Mouse1.18098402
100* AR_19668381_ChIP-Seq_PC3_Human1.17912223
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.17628434
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17177988
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16950901
104CTCF_18555785_Chip-Seq_ESCs_Mouse1.16599889
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15259496
106BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14163317
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14105555
108TCF4_22108803_ChIP-Seq_LS180_Human1.13876414
109P300_18555785_Chip-Seq_ESCs_Mouse1.13032798
110AR_25329375_ChIP-Seq_VCAP_Human1.10852287
111* TCF4_23295773_ChIP-Seq_U87_Human1.10750257
112VDR_23849224_ChIP-Seq_CD4+_Human1.10719903
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10594871
114KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10462674
115SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10377670
116CBX2_27304074_Chip-Seq_ESCs_Mouse1.10365763
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10321110
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.10125475
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09321037
120NMYC_18555785_Chip-Seq_ESCs_Mouse1.09144886
121JUN_21703547_ChIP-Seq_K562_Human1.09015402
122ZFX_18555785_Chip-Seq_ESCs_Mouse1.08987248
123RING1B_27294783_Chip-Seq_NPCs_Mouse1.08239700
124ETS1_20019798_ChIP-Seq_JURKAT_Human1.07194314
125* TAL1_26923725_Chip-Seq_HPCs_Mouse1.06686898
126FLI1_27457419_Chip-Seq_LIVER_Mouse1.06331558
127ZNF274_21170338_ChIP-Seq_K562_Hela1.06156822
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04754186
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04460244
130BCAT_22108803_ChIP-Seq_LS180_Human1.04192354
131CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03918899
132NCOR_22424771_ChIP-Seq_293T_Human1.03029436
133IGF1R_20145208_ChIP-Seq_DFB_Human1.02952200
134ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02925177
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02182777
136HOXB7_26014856_ChIP-Seq_BT474_Human1.01805539
137* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01399923
138EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01281328
139KDM2B_26808549_Chip-Seq_K562_Human1.01107007
140E2F1_21310950_ChIP-Seq_MCF-7_Human1.00068816
141PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99440790
142CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99187028
143WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99175252
144SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98748329
145TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98556091
146SMAD3_21741376_ChIP-Seq_HESCs_Human0.98318841
147CDX2_22108803_ChIP-Seq_LS180_Human0.98117057
148* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97898137
149KLF4_18555785_Chip-Seq_ESCs_Mouse0.97831115
150* RUNX2_22187159_ChIP-Seq_PCA_Human0.97758752
151* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97757494
152KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97751553
153RNF2_27304074_Chip-Seq_NSC_Mouse0.97667208
154SMAD3_21741376_ChIP-Seq_ESCs_Human0.96669820
155SMAD_19615063_ChIP-ChIP_OVARY_Human0.96598233
156* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96394526
157* ARNT_22903824_ChIP-Seq_MCF-7_Human0.95454747
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95405807
159CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95236696
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93927001
161* AHR_22903824_ChIP-Seq_MCF-7_Human0.93822897
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.91939454
163PRDM14_20953172_ChIP-Seq_ESCs_Human0.90925276
164CTCF_27219007_Chip-Seq_Bcells_Human0.88400193
165RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87157522
166RXR_22108803_ChIP-Seq_LS180_Human0.86742054
167TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86455863
168GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86091751
169TET1_21490601_ChIP-Seq_MESCs_Mouse0.86017647
170* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85710548
171NANOG_18555785_Chip-Seq_ESCs_Mouse0.84868028
172* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84467386
173TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83493627
174* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81985955
175* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80678494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.22360108
2MP0005408_hypopigmentation5.87802435
3MP0003136_yellow_coat_color5.74911660
4MP0005075_abnormal_melanosome_morpholog5.19287019
5MP0002822_catalepsy5.07226284
6MP0000015_abnormal_ear_pigmentation4.70560603
7MP0003880_abnormal_central_pattern4.58188491
8MP0003635_abnormal_synaptic_transmissio4.03926685
9MP0004270_analgesia3.84771245
10MP0002095_abnormal_skin_pigmentation3.66081376
11MP0002102_abnormal_ear_morphology3.48643103
12MP0009745_abnormal_behavioral_response3.43331059
13MP0000371_diluted_coat_color3.41021466
14MP0003646_muscle_fatigue3.33968371
15MP0002063_abnormal_learning/memory/cond3.33575044
16MP0002064_seizures3.04652340
17MP0004381_abnormal_hair_follicle2.96923117
18MP0001968_abnormal_touch/_nociception2.80748960
19MP0002572_abnormal_emotion/affect_behav2.78148195
20MP0009046_muscle_twitch2.68749555
21MP0001486_abnormal_startle_reflex2.65576318
22MP0001324_abnormal_eye_pigmentation2.63225814
23MP0002272_abnormal_nervous_system2.62774909
24MP0005174_abnormal_tail_pigmentation2.61710384
25MP0002877_abnormal_melanocyte_morpholog2.58181777
26MP0009780_abnormal_chondrocyte_physiolo2.53725292
27MP0002734_abnormal_mechanical_nocicepti2.52805468
28MP0005423_abnormal_somatic_nervous2.41483135
29MP0002938_white_spotting2.33103605
30MP0002909_abnormal_adrenal_gland2.30155910
31MP0005377_hearing/vestibular/ear_phenot2.26640997
32MP0003878_abnormal_ear_physiology2.26640997
33MP0005646_abnormal_pituitary_gland2.18913311
34MP0002736_abnormal_nociception_after2.09034949
35MP0001501_abnormal_sleep_pattern2.08259104
36MP0000372_irregular_coat_pigmentation10.5768784
37MP0003806_abnormal_nucleotide_metabolis1.98972400
38MP0002733_abnormal_thermal_nociception1.96327586
39MP0001529_abnormal_vocalization1.94886146
40MP0001970_abnormal_pain_threshold1.93358526
41MP0002075_abnormal_coat/hair_pigmentati1.87004893
42MP0002735_abnormal_chemical_nociception1.85927833
43MP0005257_abnormal_intraocular_pressure1.85011122
44MP0001440_abnormal_grooming_behavior1.80631387
45MP0005386_behavior/neurological_phenoty1.75617502
46MP0004924_abnormal_behavior1.75617502
47MP0008569_lethality_at_weaning1.75596117
48MP0002067_abnormal_sensory_capabilities1.75017452
49MP0002557_abnormal_social/conspecific_i1.72730643
50MP0004811_abnormal_neuron_physiology1.69226624
51MP0003879_abnormal_hair_cell1.63898754
52MP0001984_abnormal_olfaction1.60715809
53MP0003329_amyloid_beta_deposits1.59218177
54MP0001186_pigmentation_phenotype1.59171718
55MP0000778_abnormal_nervous_system1.50152371
56MP0002184_abnormal_innervation1.48159650
57MP0003283_abnormal_digestive_organ1.46620866
58MP0000955_abnormal_spinal_cord1.44387725
59MP0001188_hyperpigmentation1.43960678
60MP0000013_abnormal_adipose_tissue1.43824930
61MP0004885_abnormal_endolymph1.43530066
62MP0003633_abnormal_nervous_system1.38258231
63MP0005253_abnormal_eye_physiology1.37219443
64MP0005645_abnormal_hypothalamus_physiol1.36659571
65MP0010094_abnormal_chromosome_stability1.36497404
66MP0002066_abnormal_motor_capabilities/c1.35350511
67MP0004043_abnormal_pH_regulation1.33134005
68MP0001905_abnormal_dopamine_level1.33015722
69MP0002882_abnormal_neuron_morphology1.32257726
70MP0003787_abnormal_imprinting1.32063204
71MP0004858_abnormal_nervous_system1.30588857
72MP0001502_abnormal_circadian_rhythm1.30133967
73MP0005248_abnormal_Harderian_gland1.28582931
74MP0005409_darkened_coat_color1.22705041
75MP0010386_abnormal_urinary_bladder1.14065703
76MP0010234_abnormal_vibrissa_follicle1.13570961
77MP0006276_abnormal_autonomic_nervous1.12117438
78MP0003631_nervous_system_phenotype1.09459684
79MP0005197_abnormal_uvea_morphology1.07406126
80MP0004142_abnormal_muscle_tone1.02179620
81MP0001177_atelectasis1.01554834
82MP0000920_abnormal_myelination1.01064199
83MP0002229_neurodegeneration0.99673081
84MP0003075_altered_response_to0.99609922
85MP0002069_abnormal_eating/drinking_beha0.97078946
86MP0008874_decreased_physiological_sensi0.96880799
87MP0003950_abnormal_plasma_membrane0.96626949
88MP0005535_abnormal_body_temperature0.96492941
89MP0002152_abnormal_brain_morphology0.96069497
90MP0004085_abnormal_heartbeat0.92449375
91MP0005551_abnormal_eye_electrophysiolog0.91416859
92MP0005187_abnormal_penis_morphology0.90904426
93MP0003690_abnormal_glial_cell0.90425632
94MP0003634_abnormal_glial_cell0.90226580
95MP0000631_abnormal_neuroendocrine_gland0.89041261
96MP0008872_abnormal_physiological_respon0.88107592
97MP0008961_abnormal_basal_metabolism0.87740447
98MP0004145_abnormal_muscle_electrophysio0.83379982
99MP0002090_abnormal_vision0.82581653
100MP0003122_maternal_imprinting0.81012771
101MP0006036_abnormal_mitochondrial_physio0.80345919
102MP0004742_abnormal_vestibular_system0.78591787
103MP0002837_dystrophic_cardiac_calcinosis0.78399576
104MP0005394_taste/olfaction_phenotype0.78179674
105MP0005499_abnormal_olfactory_system0.78179674
106MP0003183_abnormal_peptide_metabolism0.77585207
107MP0001485_abnormal_pinna_reflex0.75907446
108MP0004233_abnormal_muscle_weight0.75023413
109MP0008058_abnormal_DNA_repair0.74958786
110MP0002638_abnormal_pupillary_reflex0.74296729
111MP0005167_abnormal_blood-brain_barrier0.73813244
112MP0001664_abnormal_digestion0.73113569
113MP0000569_abnormal_digit_pigmentation0.73014246
114MP0001963_abnormal_hearing_physiology0.71444806
115MP0002693_abnormal_pancreas_physiology0.68709838
116MP0002876_abnormal_thyroid_physiology0.67945567
117MP0003632_abnormal_nervous_system0.66688304
118MP0000751_myopathy0.65712145
119MP0003718_maternal_effect0.65124585
120MP0002752_abnormal_somatic_nervous0.63426300
121MP0004484_altered_response_of0.62287633
122MP0005171_absent_coat_pigmentation0.60786504
123MP0005379_endocrine/exocrine_gland_phen0.59458769
124MP0000604_amyloidosis0.59313198
125MP0003186_abnormal_redox_activity0.58388587
126MP0003111_abnormal_nucleus_morphology0.57449192
127MP0003137_abnormal_impulse_conducting0.57285542
128MP0002177_abnormal_outer_ear0.56969640
129MP0003172_abnormal_lysosome_physiology0.55144941
130MP0006072_abnormal_retinal_apoptosis0.54681280
131MP0001765_abnormal_ion_homeostasis0.54596194
132MP0001944_abnormal_pancreas_morphology0.53686095
133MP0000749_muscle_degeneration0.52398889
134MP0001943_abnormal_respiration0.51148700
135MP0001299_abnormal_eye_distance/0.50863838
136MP0000647_abnormal_sebaceous_gland0.50837806
137MP0005391_vision/eye_phenotype0.50740123
138MP0000003_abnormal_adipose_tissue0.50102877
139MP0000427_abnormal_hair_cycle0.48540827
140MP0004147_increased_porphyrin_level0.47882429
141MP0006138_congestive_heart_failure0.41859513
142MP0006054_spinal_hemorrhage0.38524365
143MP0010678_abnormal_skin_adnexa0.36472112
144MP0008877_abnormal_DNA_methylation0.36237180
145MP0003077_abnormal_cell_cycle0.35234088
146MP0008057_abnormal_DNA_replication0.35177038
147MP0005193_abnormal_anterior_eye0.33681235
148MP0002396_abnormal_hematopoietic_system0.32596252
149MP0005195_abnormal_posterior_eye0.32303605
150MP0003195_calcinosis0.30662779
151MP0000367_abnormal_coat/_hair0.29678293
152MP0002282_abnormal_trachea_morphology0.26903051
153MP0005389_reproductive_system_phenotype0.20047860
154MP0005165_increased_susceptibility_to0.19453682
155MP0001919_abnormal_reproductive_system0.18661511
156MP0003698_abnormal_male_reproductive0.18610627
157MP0000026_abnormal_inner_ear0.16877497
158MP0001929_abnormal_gametogenesis0.14725234
159MP0000516_abnormal_urinary_system0.14518799
160MP0005367_renal/urinary_system_phenotyp0.14518799
161MP0002751_abnormal_autonomic_nervous0.12449602
162MP0000358_abnormal_cell_content/0.12293232
163MP0003943_abnormal_hepatobiliary_system0.12186503
164MP0009115_abnormal_fat_cell0.11623424

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the macula (HP:0008059)9.85972318
2Ocular albinism (HP:0001107)9.66510606
3Aplasia/Hypoplasia affecting the retina (HP:0008061)9.15427407
4Iris hypopigmentation (HP:0007730)8.75645020
5Hypoplasia of the fovea (HP:0007750)7.77152168
6Aplasia/Hypoplasia of the fovea (HP:0008060)7.77152168
7Focal motor seizures (HP:0011153)7.75060678
8Myokymia (HP:0002411)7.55559508
9Abnormality of the fovea (HP:0000493)6.83327484
10White forelock (HP:0002211)6.44215341
11Congenital stationary night blindness (HP:0007642)6.32849124
12Patchy hypopigmentation of hair (HP:0011365)6.32292221
13Generalized hypopigmentation (HP:0007513)6.00685025
14Hypopigmentation of the fundus (HP:0007894)5.96345759
15Focal seizures (HP:0007359)5.48106107
16Visual hallucinations (HP:0002367)5.22160397
17Decreased central vision (HP:0007663)4.89392523
18Abnormal auditory evoked potentials (HP:0006958)4.68718893
19Epileptic encephalopathy (HP:0200134)4.56192917
20Freckling (HP:0001480)4.32371680
21Albinism (HP:0001022)4.31719393
22Cutaneous melanoma (HP:0012056)4.27754872
23Atonic seizures (HP:0010819)4.02642532
24Ankle clonus (HP:0011448)3.86495072
25Febrile seizures (HP:0002373)3.85049839
26Generalized tonic-clonic seizures (HP:0002069)3.62219684
27Congenital sensorineural hearing impairment (HP:0008527)3.61693854
28Action tremor (HP:0002345)3.61090520
29Absence seizures (HP:0002121)3.60799410
30Poor eye contact (HP:0000817)3.50608296
31Broad-based gait (HP:0002136)3.50498999
32Dialeptic seizures (HP:0011146)3.46355363
33Depression (HP:0000716)3.41379900
34Anxiety (HP:0000739)3.40270374
35Progressive cerebellar ataxia (HP:0002073)3.37997175
36Aplasia/Hypoplasia affecting the fundus (HP:0008057)3.34690610
37Heterochromia iridis (HP:0001100)3.30299855
38Impaired vibration sensation in the lower limbs (HP:0002166)3.28033183
39Gaze-evoked nystagmus (HP:0000640)3.26617212
40Supranuclear gaze palsy (HP:0000605)3.25656334
41Torticollis (HP:0000473)3.22780449
42Horizontal nystagmus (HP:0000666)3.21962207
43Hyperventilation (HP:0002883)3.15028329
44Impaired social interactions (HP:0000735)3.06202355
45Abnormal social behavior (HP:0012433)3.06202355
46Urinary bladder sphincter dysfunction (HP:0002839)3.05959565
47Premature graying of hair (HP:0002216)3.05771757
48Dysdiadochokinesis (HP:0002075)3.01960323
49Generalized hypopigmentation of hair (HP:0011358)3.01267807
50Resting tremor (HP:0002322)2.99636497
51Dysmetria (HP:0001310)2.98794639
52Fibular hypoplasia (HP:0003038)2.92306280
53Papilledema (HP:0001085)2.92139105
54Truncal ataxia (HP:0002078)2.91119080
55Focal dystonia (HP:0004373)2.88816856
56Frequent falls (HP:0002359)2.85950729
57Intestinal atresia (HP:0011100)2.83639849
58Annular pancreas (HP:0001734)2.77674259
59Amblyopia (HP:0000646)2.76651757
60Spastic gait (HP:0002064)2.76274037
61Postural instability (HP:0002172)2.73673025
62Epileptiform EEG discharges (HP:0011182)2.71133240
63Scanning speech (HP:0002168)2.69815218
64Craniofacial dystonia (HP:0012179)2.69094935
65Abnormal eating behavior (HP:0100738)2.68292900
66Impaired smooth pursuit (HP:0007772)2.64439597
67EEG with generalized epileptiform discharges (HP:0011198)2.60603109
68Neurofibrillary tangles (HP:0002185)2.59916824
69Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.59248316
70Stereotypic behavior (HP:0000733)2.58264410
71Dyschromatopsia (HP:0007641)2.58028096
72Urinary urgency (HP:0000012)2.57213100
73Megalencephaly (HP:0001355)2.51641481
74Hypsarrhythmia (HP:0002521)2.51554332
75Hypoplasia of the iris (HP:0007676)2.43578600
76Astigmatism (HP:0000483)2.43324435
77Abnormality of the anterior horn cell (HP:0006802)2.41737927
78Degeneration of anterior horn cells (HP:0002398)2.41737927
79Limb dystonia (HP:0002451)2.40240863
80Intention tremor (HP:0002080)2.39469651
81Impaired vibratory sensation (HP:0002495)2.38454890
82Drooling (HP:0002307)2.37484008
83Excessive salivation (HP:0003781)2.37484008
84Termporal pattern (HP:0011008)2.36143496
85Insidious onset (HP:0003587)2.36143496
86Cerebral inclusion bodies (HP:0100314)2.35687713
87Bradykinesia (HP:0002067)2.35551986
88Hemiparesis (HP:0001269)2.33234722
89Bilateral sensorineural hearing impairment (HP:0008619)2.32652189
90Facial cleft (HP:0002006)2.32340753
91Pheochromocytoma (HP:0002666)2.29908055
92Clonus (HP:0002169)2.27841277
93Mutism (HP:0002300)2.22660722
94Dysmetric saccades (HP:0000641)2.22168549
95Hamartoma of the eye (HP:0010568)2.20647732
96Lower limb muscle weakness (HP:0007340)2.20410171
97Genetic anticipation (HP:0003743)2.17683860
98Aplasia/Hypoplasia of the fibula (HP:0006492)2.16337733
99Prolonged QT interval (HP:0001657)2.16193348
100Abnormality of ocular smooth pursuit (HP:0000617)2.13645055
101Progressive inability to walk (HP:0002505)2.13583444
102Absent speech (HP:0001344)2.12422686
103Abnormal EKG (HP:0003115)2.11916717
104Abnormality of the corticospinal tract (HP:0002492)2.11714974
105Abnormality of glycolysis (HP:0004366)2.11579137
106Adrenal hypoplasia (HP:0000835)2.09538901
107Blue irides (HP:0000635)2.04493413
108Bifid tongue (HP:0010297)2.03544464
109Ankyloglossia (HP:0010296)2.03404898
110Abnormality of binocular vision (HP:0011514)2.01189783
111Diplopia (HP:0000651)2.01189783
112Progressive macrocephaly (HP:0004481)1.99951935
113Gait imbalance (HP:0002141)1.99424987
114Incomplete penetrance (HP:0003829)1.99066181
115Lower limb amyotrophy (HP:0007210)1.94980438
116Acute necrotizing encephalopathy (HP:0006965)1.94947827
117Tongue fasciculations (HP:0001308)1.94936911
118Fetal akinesia sequence (HP:0001989)1.94922211
119Increased CSF lactate (HP:0002490)1.94671488
120Ventricular fibrillation (HP:0001663)1.94439403
121Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93439262
122Degeneration of the lateral corticospinal tracts (HP:0002314)1.93439262
123Gait ataxia (HP:0002066)1.93077488
124Epidermoid cyst (HP:0200040)1.92701960
125Abnormality of the lower motor neuron (HP:0002366)1.92539389
126Generalized myoclonic seizures (HP:0002123)1.91090872
127Pointed chin (HP:0000307)1.90888782
128Neuroendocrine neoplasm (HP:0100634)1.90314473
129Bundle branch block (HP:0011710)1.90008558
130Subaortic stenosis (HP:0001682)1.84625321
131Abnormality of the left ventricular outflow tract (HP:0011103)1.84625321
132Cortical visual impairment (HP:0100704)1.84407889
133Enlarged kidneys (HP:0000105)1.83733601
134Mitochondrial inheritance (HP:0001427)1.83608290
135Abnormal mitochondria in muscle tissue (HP:0008316)1.83565652
136Acute encephalopathy (HP:0006846)1.83424247
137Agitation (HP:0000713)1.83178008
138Abnormality of the periventricular white matter (HP:0002518)1.82799958
139Melanoma (HP:0002861)1.82386388
140Median cleft lip (HP:0000161)1.80448332
141Long clavicles (HP:0000890)1.80334006
142Status epilepticus (HP:0002133)1.80271715
143Abnormality of saccadic eye movements (HP:0000570)1.77707616
144Rigidity (HP:0002063)1.77341278
145Neuronal loss in central nervous system (HP:0002529)1.77281724
146Hemiplegia (HP:0002301)1.76710300
147Inability to walk (HP:0002540)1.76505576
148Photophobia (HP:0000613)1.75267215
149Spinal canal stenosis (HP:0003416)1.74314100
150Obstructive sleep apnea (HP:0002870)1.73037580
151Specific learning disability (HP:0001328)1.72922015
152Insomnia (HP:0100785)1.72328172
153Cholecystitis (HP:0001082)1.71309990
154Abnormal gallbladder physiology (HP:0012438)1.71309990
155Thickened helices (HP:0000391)1.70881196
156Hypokinesia (HP:0002375)1.69264988
157Ependymoma (HP:0002888)1.68745459
158Poor head control (HP:0002421)1.67708365
159Neoplasm of the adrenal cortex (HP:0100641)1.64914618
160Muscle fibrillation (HP:0010546)1.63841348
161Volvulus (HP:0002580)1.63132823
162Hepatocellular necrosis (HP:0001404)1.61563884
163Abnormality of chromosome stability (HP:0003220)1.58366430
164Chromosomal breakage induced by crosslinking agents (HP:0003221)1.57139647
165Astrocytoma (HP:0009592)1.54573618
166Abnormality of the astrocytes (HP:0100707)1.54573618
167Abnormality of the pupil (HP:0000615)1.54553662
168Chromsome breakage (HP:0040012)1.50617179
169Increased intramyocellular lipid droplets (HP:0012240)1.50203847
170Small hand (HP:0200055)1.47970758
171Increased hepatocellular lipid droplets (HP:0006565)1.47380873
172Renal Fanconi syndrome (HP:0001994)1.44587675
173Spastic paraparesis (HP:0002313)1.44212503
174Small intestinal stenosis (HP:0012848)1.43625801
175Duodenal stenosis (HP:0100867)1.43625801
176Lipid accumulation in hepatocytes (HP:0006561)1.42812385
177Aplasia cutis congenita (HP:0001057)1.42239343
178Decreased electroretinogram (ERG) amplitude (HP:0000654)1.41918703
179Abnormality of macular pigmentation (HP:0008002)1.41794208
180Delusions (HP:0000746)1.39828513
181Spinal muscular atrophy (HP:0007269)1.39525004
182Aplasia/Hypoplasia of the uvula (HP:0010293)1.39094475
183Hepatic necrosis (HP:0002605)1.37591604
184Neoplasm of the heart (HP:0100544)1.37538444
185Gastrointestinal atresia (HP:0002589)1.37279808
186Vitreoretinal degeneration (HP:0000655)1.36710249
187Abnormal delayed hypersensitivity skin test (HP:0002963)1.31755662
188Abnormal lung lobation (HP:0002101)1.31485807
189Renal dysplasia (HP:0000110)1.30234711
190Neoplasm of the adrenal gland (HP:0100631)1.29041810
191Cerebral edema (HP:0002181)1.27298768
192Increased serum pyruvate (HP:0003542)1.27084130
193Abnormality of chromosome segregation (HP:0002916)1.26182214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.99497098
2WEE15.33253275
3NTRK34.23771088
4PDK24.18454230
5FRK3.88732368
6EIF2AK13.67361804
7MST1R3.65456204
8MAP3K93.29725142
9TRIM283.14725385
10BMPR1B3.02334592
11DAPK22.97884396
12MARK32.63177749
13PRKD32.63144904
14ACVR1B2.54128145
15MARK12.41047309
16MAP3K42.40597990
17KSR22.24723417
18GRK62.18151619
19MINK12.17685267
20EIF2AK32.15900646
21SIK32.13195566
22RIPK42.12725378
23MAP2K72.08345802
24CASK2.07092327
25NTRK12.05841504
26PLK32.05738273
27ERBB32.01596643
28CAMKK11.98721521
29PAK61.89862219
30PRPF4B1.78019707
31NTRK21.71425640
32MAP3K21.69043747
33DAPK11.65431587
34TNIK1.65247184
35CDK51.63192891
36CAMKK21.58584422
37FER1.56744241
38ARAF1.50598204
39KSR11.46356918
40FES1.40522461
41MAP3K131.37252860
42CDK191.36591905
43MAP2K41.35343432
44CSNK1G31.32815522
45TGFBR21.28748697
46INSRR1.27279339
47MAP3K121.27130272
48SGK2231.25625533
49SGK4941.25625533
50UHMK11.18063953
51MAPK131.15115798
52CSNK1A1L1.13994589
53TYRO31.13597208
54BMPR21.12238220
55GRK51.11756169
56PLK21.10586534
57SIK21.06741216
58TAOK11.06713308
59MET1.05311149
60CSNK1G11.04195770
61PRKCG1.02378029
62OXSR11.00669679
63PRKCH1.00513843
64LATS10.98650346
65SGK20.98437955
66ADRBK10.97971196
67CAMK2A0.94588649
68CAMK2B0.93469098
69STK380.92993662
70ATR0.91565785
71PINK10.89796901
72MAP3K10.87341045
73MAP4K20.86762277
74MARK20.85224430
75NEK60.84884930
76PLK40.84260772
77CDK180.83765026
78CDK150.81868253
79CDK140.81194500
80STK110.80836563
81SGK30.80813336
82STK30.80091669
83RAF10.79975137
84CAMK10.79718204
85PLK10.79107608
86MAP3K30.78280707
87SGK10.76839066
88PRKAA20.75669937
89RET0.74384954
90PTK2B0.72794326
91PDPK10.72433900
92PRKD10.71984042
93CDK11A0.71142609
94CSNK1D0.70512823
95NUAK10.68886203
96NEK10.67719139
97BCKDK0.67217880
98ADRBK20.67104400
99PDK10.66546437
100AKT30.63548121
101PHKG20.62983334
102PHKG10.62983334
103PNCK0.62836682
104CDC70.62655174
105PRKCE0.61444522
106AKT20.58653640
107PAK30.58195148
108EIF2AK20.57326844
109ATM0.56332899
110BRAF0.55743485
111CAMK2D0.54459381
112CDK30.54278715
113TNK20.53975753
114CSNK1A10.53356171
115KIT0.53260096
116CDC42BPA0.52989362
117DYRK1A0.52901378
118TGFBR10.52825077
119GSK3A0.52595430
120CSNK1G20.51558695
121ZAK0.51168705
122BRSK20.50103336
123ALK0.49810942
124BUB10.49282259
125RPS6KA30.49206615
126WNK10.48499095
127MAP2K10.47321246
128CAMK40.46451971
129PRKCZ0.46071761
130DAPK30.45725532
131FYN0.45431270
132CCNB10.44735776
133PRKD20.43488254
134CHEK20.43436142
135WNK40.42921501
136CAMK2G0.42681168
137WNK30.41761920
138HIPK20.41313883
139MATK0.40019453
140SYK0.39771267
141GRK10.39615230
142CDK70.39198618
143BCR0.38480780
144STK390.37854076
145RPS6KA20.36764818
146EGFR0.35258745
147FGFR20.35041074
148MAPKAPK50.35040519
149DMPK0.34799758
150LMTK20.34568407
151FGR0.34163450
152* MAPK100.33764703
153BRSK10.33614536
154ABL20.27097912
155TYK20.25970239
156IGF1R0.25928671
157NEK20.25909259
158PRKACA0.25434940
159MAPKAPK30.23582881
160CSNK2A10.23218708
161MKNK20.22558303
162STK38L0.22520053
163ABL10.21977592
164IKBKB0.19670578
165LYN0.19505568
166TAOK30.18905434
167TSSK60.18782422
168PRKACB0.18638845
169FGFR30.17427466
170PRKDC0.16153677

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.66609612
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.58164238
3Homologous recombination_Homo sapiens_hsa034403.57521789
4Protein export_Homo sapiens_hsa030603.36493188
5Olfactory transduction_Homo sapiens_hsa047403.15964794
6Synaptic vesicle cycle_Homo sapiens_hsa047213.12840728
7Proteasome_Homo sapiens_hsa030503.08845107
8Nicotine addiction_Homo sapiens_hsa050333.05974078
9Tyrosine metabolism_Homo sapiens_hsa003503.03522467
10Parkinsons disease_Homo sapiens_hsa050122.79089244
11Circadian entrainment_Homo sapiens_hsa047132.77867057
12Morphine addiction_Homo sapiens_hsa050322.70931197
13Amphetamine addiction_Homo sapiens_hsa050312.68927166
14Oxidative phosphorylation_Homo sapiens_hsa001902.68139249
15GABAergic synapse_Homo sapiens_hsa047272.66469672
16Long-term potentiation_Homo sapiens_hsa047202.64194626
17Glutamatergic synapse_Homo sapiens_hsa047242.53631253
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53206161
19Insulin secretion_Homo sapiens_hsa049112.35853737
20Dopaminergic synapse_Homo sapiens_hsa047282.32825920
21Cocaine addiction_Homo sapiens_hsa050302.22609198
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16939639
23Cholinergic synapse_Homo sapiens_hsa047252.10227943
24Salivary secretion_Homo sapiens_hsa049702.04041805
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95820142
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95764144
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95090444
28Sulfur metabolism_Homo sapiens_hsa009201.94509789
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88373321
30Fanconi anemia pathway_Homo sapiens_hsa034601.83360273
31Renin secretion_Homo sapiens_hsa049241.82258623
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.80320803
33Taste transduction_Homo sapiens_hsa047421.79894172
34Propanoate metabolism_Homo sapiens_hsa006401.76920402
35Gastric acid secretion_Homo sapiens_hsa049711.76168327
36Fatty acid elongation_Homo sapiens_hsa000621.74992227
37Serotonergic synapse_Homo sapiens_hsa047261.74371294
38Pentose phosphate pathway_Homo sapiens_hsa000301.69596103
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64012217
40Mismatch repair_Homo sapiens_hsa034301.62863985
41Oxytocin signaling pathway_Homo sapiens_hsa049211.61537816
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60880003
43Long-term depression_Homo sapiens_hsa047301.59105637
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56581302
45Calcium signaling pathway_Homo sapiens_hsa040201.55558296
46Huntingtons disease_Homo sapiens_hsa050161.54849166
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53229440
48Sphingolipid metabolism_Homo sapiens_hsa006001.48023862
49Collecting duct acid secretion_Homo sapiens_hsa049661.45935642
50Gap junction_Homo sapiens_hsa045401.41116187
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39000327
52Type II diabetes mellitus_Homo sapiens_hsa049301.37968328
53GnRH signaling pathway_Homo sapiens_hsa049121.37835021
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.35660019
55Glutathione metabolism_Homo sapiens_hsa004801.34296634
56cAMP signaling pathway_Homo sapiens_hsa040241.32294661
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30053626
58Basal transcription factors_Homo sapiens_hsa030221.28966112
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25793090
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23724632
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18183668
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16324328
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15896789
64Vibrio cholerae infection_Homo sapiens_hsa051101.15411343
65One carbon pool by folate_Homo sapiens_hsa006701.08401083
66Estrogen signaling pathway_Homo sapiens_hsa049151.07514684
67cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06573386
68Glioma_Homo sapiens_hsa052141.06230442
69Vascular smooth muscle contraction_Homo sapiens_hsa042701.04944266
70Phototransduction_Homo sapiens_hsa047441.04772353
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04687642
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03011014
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01648753
74Axon guidance_Homo sapiens_hsa043600.97951425
75Melanogenesis_Homo sapiens_hsa049160.96790131
76ErbB signaling pathway_Homo sapiens_hsa040120.96238151
77p53 signaling pathway_Homo sapiens_hsa041150.95275897
78Chemical carcinogenesis_Homo sapiens_hsa052040.94819008
79Pyruvate metabolism_Homo sapiens_hsa006200.91867796
80Pancreatic secretion_Homo sapiens_hsa049720.90726600
81Type I diabetes mellitus_Homo sapiens_hsa049400.90114679
82Fatty acid degradation_Homo sapiens_hsa000710.89683494
83RNA degradation_Homo sapiens_hsa030180.87922895
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.87190369
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.84305930
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84191532
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83627509
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82881963
89Cell cycle_Homo sapiens_hsa041100.82719652
90Nitrogen metabolism_Homo sapiens_hsa009100.82685684
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80726972
92Dorso-ventral axis formation_Homo sapiens_hsa043200.80451126
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80237483
94Fatty acid metabolism_Homo sapiens_hsa012120.79929740
95Thyroid hormone synthesis_Homo sapiens_hsa049180.78730155
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77809942
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.76517490
98RNA transport_Homo sapiens_hsa030130.75899069
99Alcoholism_Homo sapiens_hsa050340.75594969
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75230786
101DNA replication_Homo sapiens_hsa030300.73915749
102Metabolic pathways_Homo sapiens_hsa011000.73222720
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73199879
104Tryptophan metabolism_Homo sapiens_hsa003800.71860430
105Cardiac muscle contraction_Homo sapiens_hsa042600.70031362
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69256249
107Nucleotide excision repair_Homo sapiens_hsa034200.69059468
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68926424
109Oocyte meiosis_Homo sapiens_hsa041140.68897374
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68434159
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67777148
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67628885
113Choline metabolism in cancer_Homo sapiens_hsa052310.67600550
114Circadian rhythm_Homo sapiens_hsa047100.67223489
115MAPK signaling pathway_Homo sapiens_hsa040100.66224489
116Prostate cancer_Homo sapiens_hsa052150.65901081
117beta-Alanine metabolism_Homo sapiens_hsa004100.65498751
118Dilated cardiomyopathy_Homo sapiens_hsa054140.61713651
119Ras signaling pathway_Homo sapiens_hsa040140.60896398
120Glucagon signaling pathway_Homo sapiens_hsa049220.60001653
121Base excision repair_Homo sapiens_hsa034100.59815542
122Histidine metabolism_Homo sapiens_hsa003400.59528850
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.57825551
124Rap1 signaling pathway_Homo sapiens_hsa040150.57496606
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.56966151
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55164371
127Carbon metabolism_Homo sapiens_hsa012000.54947578
128VEGF signaling pathway_Homo sapiens_hsa043700.53781225
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.53477265
130Glycerolipid metabolism_Homo sapiens_hsa005610.52760456
131Small cell lung cancer_Homo sapiens_hsa052220.51118993
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51044710
133Non-small cell lung cancer_Homo sapiens_hsa052230.50558742
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49894587
135Prion diseases_Homo sapiens_hsa050200.49796517
136Endocytosis_Homo sapiens_hsa041440.49350994
137RNA polymerase_Homo sapiens_hsa030200.48381167
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48048972
139Inositol phosphate metabolism_Homo sapiens_hsa005620.48043243
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44034226
141Linoleic acid metabolism_Homo sapiens_hsa005910.43494909
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43385791
143Chemokine signaling pathway_Homo sapiens_hsa040620.43333279
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43194647
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43179808
146Renal cell carcinoma_Homo sapiens_hsa052110.42857259
147Ovarian steroidogenesis_Homo sapiens_hsa049130.42181288
148Cysteine and methionine metabolism_Homo sapiens_hsa002700.41991598
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41175561
150mTOR signaling pathway_Homo sapiens_hsa041500.41063906
151Caffeine metabolism_Homo sapiens_hsa002320.40788927
152Lysosome_Homo sapiens_hsa041420.39443986
153Peroxisome_Homo sapiens_hsa041460.39384492
154Melanoma_Homo sapiens_hsa052180.39197437
155Regulation of autophagy_Homo sapiens_hsa041400.38157729
156Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37520736
157Endometrial cancer_Homo sapiens_hsa052130.37070888
158Insulin signaling pathway_Homo sapiens_hsa049100.35664487
159Other glycan degradation_Homo sapiens_hsa005110.33975329
160Bile secretion_Homo sapiens_hsa049760.32676427
161Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32620419
162Herpes simplex infection_Homo sapiens_hsa051680.31999884
163Drug metabolism - other enzymes_Homo sapiens_hsa009830.31795586
164Wnt signaling pathway_Homo sapiens_hsa043100.31294233
165Glycerophospholipid metabolism_Homo sapiens_hsa005640.30558608
166Prolactin signaling pathway_Homo sapiens_hsa049170.29919019
167Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28860947
168African trypanosomiasis_Homo sapiens_hsa051430.28375881
169Butanoate metabolism_Homo sapiens_hsa006500.27874365
170alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27443620
171Alzheimers disease_Homo sapiens_hsa050100.27264546
172Purine metabolism_Homo sapiens_hsa002300.26621846
173Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25973513
174Arginine and proline metabolism_Homo sapiens_hsa003300.23091149
175Rheumatoid arthritis_Homo sapiens_hsa053230.22669867
176Biosynthesis of amino acids_Homo sapiens_hsa012300.21255723

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